Stefano Morotti

Title(s)Assistant Professor, Pharmacology
SchoolSchool of Medicine
ORCID ORCID Icon0000-0001-8679-665X Additional info
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    Modeling of subcellular signaling crosstalk in failing myocytes
    NIH R00HL138160Jun 15, 2020 - Apr 30, 2023
    Role: Principal Investigator
    Modeling of subcellular signaling crosstalk in failing myocytes
    NIH K99HL138160Apr 13, 2018 - Jun 14, 2020
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Integrative human atrial modelling unravels interactive protein kinase A and Ca2+/calmodulin-dependent protein kinase II signalling as key determinants of atrial arrhythmogenesis. Cardiovasc Res. 2023 Oct 24; 119(13):2294-2311. Ni H, Morotti S, Zhang X, Dobrev D, Grandi E. PMID: 37523735.
      View in: PubMed   Mentions: 1     Fields:    
    2. Predictive Male-to-Female Translation of Cardiac Electrophysiological Response to Drugs. JACC Clin Electrophysiol. 2023 Dec; 9(12):2642-2648. Hellgren KT, Ni H, Morotti S, Grandi E. PMID: 37768254.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Dual effects of the small-conductance Ca2+-activated K+ current on human atrial electrophysiology and Ca2+-driven arrhythmogenesis: an in silico study. Am J Physiol Heart Circ Physiol. 2023 10 01; 325(4):H896-H908. Herrera NT, Zhang X, Ni H, Maleckar MM, Heijman J, Dobrev D, Grandi E, Morotti S. PMID: 37624096; PMCID: PMC10659325.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Cardiac Protein Kinase D1 ablation alters the myocytes β-adrenergic response. J Mol Cell Cardiol. 2023 07; 180:33-43. Mira Hernandez J, Ko CY, Mandel AR, Shen EY, Baidar S, Christensen AR, Hellgren K, Morotti S, Martin JL, Hegyi B, Bossuyt J, Bers DM. PMID: 37149124.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    5. Enhanced Ca2+-Dependent SK-Channel Gating and Membrane Trafficking in Human Atrial Fibrillation. Circ Res. 2023 04 28; 132(9):e116-e133. Heijman J, Zhou X, Morotti S, Molina CE, Abu-Taha IH, Tekook M, Jespersen T, Zhang Y, Dobrev S, Milting H, Gummert J, Karck M, Kamler M, El-Armouche A, Saljic A, Grandi E, Nattel S, Dobrev D. PMID: 36927079; PMCID: PMC10147588.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    6. The funny current If is essential for the fight-or-flight response in cardiac pacemaker cells. J Gen Physiol. 2022 12 05; 154(12). Peters CH, Rickert C, Morotti S, Grandi E, Aronow KA, Beam KG, Proenza C. PMID: 36305844; PMCID: PMC9812006.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    7. Mechanisms of spontaneous Ca2+ release-mediated arrhythmia in a novel 3D human atrial myocyte model: I. Transverse-axial tubule variation. J Physiol. 2023 Jul; 601(13):2655-2683. Zhang X, Ni H, Morotti S, Smith CER, Sato D, Louch WE, Edwards AG, Grandi E. PMID: 36094888; PMCID: PMC10008525.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    8. A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene. Elife. 2022 Oct 18; 11. Ding Y, Lang D, Yan J, Bu H, Li H, Jiao K, Yang J, Ni H, Morotti S, Le T, Clark KJ, Port J, Ekker SC, Cao H, Zhang Y, Wang J, Grandi E, Li Z, Shi Y, Li Y, Glukhov AV, Xu X. PMID: 36255053; PMCID: PMC9642998.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    9. Mechanisms of spontaneous Ca2+ release-mediated arrhythmia in a novel 3D human atrial myocyte model: II. Ca2+ -handling protein variation. J Physiol. 2023 Jul; 601(13):2685-2710. Zhang X, Smith CER, Morotti S, Edwards AG, Sato D, Louch WE, Ni H, Grandi E. PMID: 36114707; PMCID: PMC10017376.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    10. Quantitative cross-species translators of cardiac myocyte electrophysiology: Model training, experimental validation, and applications. Sci Adv. 2021 Nov 19; 7(47):eabg0927. Morotti S, Liu C, Hegyi B, Ni H, Fogli Iseppe A, Wang L, Pritoni M, Ripplinger CM, Bers DM, Edwards AG, Grandi E. PMID: 34788089; PMCID: PMC8598003.
      View in: PubMed   Mentions: 13     Fields:    
    11. Bidirectional flow of the funny current (If) during the pacemaking cycle in murine sinoatrial node myocytes. Proc Natl Acad Sci U S A. 2021 07 13; 118(28). Peters CH, Liu PW, Morotti S, Gantz SC, Grandi E, Bean BP, Proenza C. PMID: 34260402; PMCID: PMC8285948.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    12. Intracellular Na+ Modulates Pacemaking Activity in Murine Sinoatrial Node Myocytes: An In Silico Analysis. Int J Mol Sci. 2021 May 26; 22(11). Morotti S, Ni H, Peters CH, Rickert C, Asgari-Targhi A, Sato D, Glukhov AV, Proenza C, Grandi E. PMID: 34073281; PMCID: PMC8198068.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    13. Sex-Specific Classification of Drug-Induced Torsade de Pointes Susceptibility Using Cardiac Simulations and Machine Learning. Clin Pharmacol Ther. 2021 08; 110(2):380-391. Fogli Iseppe A, Ni H, Zhu S, Zhang X, Coppini R, Yang PC, Srivatsa U, Clancy CE, Edwards AG, Morotti S, Grandi E. PMID: 33772748; PMCID: PMC8316283.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    14. CaMKIIδC Drives Early Adaptive Ca2+ Change and Late Eccentric Cardiac Hypertrophy. Circ Res. 2020 10 09; 127(9):1159-1178. Ljubojevic-Holzer S, Herren AW, Djalinac N, Voglhuber J, Morotti S, Holzer M, Wood BM, Abdellatif M, Matzer I, Sacherer M, Radulovic S, Wallner M, Ivanov M, Wagner S, Sossalla S, von Lewinski D, Pieske B, Brown JH, Sedej S, Bossuyt J, Bers DM. PMID: 32821022; PMCID: PMC7547876.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    15. Populations of in silico myocytes and tissues reveal synergy of multiatrial-predominant K+ -current block in atrial fibrillation. Br J Pharmacol. 2020 10; 177(19):4497-4515. Ni H, Fogli Iseppe A, Giles WR, Narayan SM, Zhang H, Edwards AG, Morotti S, Grandi E. PMID: 32667679; PMCID: PMC7484508.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    16. GRK5 Controls SAP97-Dependent Cardiotoxic β1 Adrenergic Receptor-CaMKII Signaling in Heart Failure. Circ Res. 2020 08 28; 127(6):796-810. Xu B, Li M, Wang Y, Zhao M, Morotti S, Shi Q, Wang Q, Barbagallo F, Teoh JP, Reddy GR, Bayne EF, Liu Y, Shen A, Puglisi JL, Ge Y, Li J, Grandi E, Nieves-Cintron M, Xiang YK. PMID: 32507058; PMCID: PMC7484403.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    17. Hypokalemia Promotes Arrhythmia by Distinct Mechanisms in Atrial and Ventricular Myocytes. Circ Res. 2020 03 27; 126(7):889-906. Tazmini K, Frisk M, Lewalle A, Laasmaa M, Morotti S, Lipsett DB, Manfra O, Skogestad J, Aronsen JM, Sejersted OM, Sjaastad I, Edwards AG, Grandi E, Niederer SA, Øie E, Louch WE. PMID: 32070187; PMCID: PMC7098435.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    18. General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy. Clin Pharmacol Ther. 2020 01; 107(1):102-111. Li Z, Mirams GR, Yoshinaga T, Ridder BJ, Han X, Chen JE, Stockbridge NL, Wisialowski TA, Damiano B, Severi S, Morissette P, Kowey PR, Holbrook M, Smith G, Rasmusson RL, Liu M, Song Z, Qu Z, Leishman DJ, Steidl-Nichols J, Rodriguez B, Bueno-Orovio A, Zhou X, Passini E, Edwards AG, Morotti S, Ni H, Grandi E, Clancy CE, Vandenberg J, Hill A, Nakamura M, Singer T, Polonchuk L, Greiter-Wilke A, Wang K, Nave S, Fullerton A, Sobie EA, Paci M, Musuamba Tshinanu F, Strauss DG. PMID: 31709525; PMCID: PMC6977398.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    19. A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources. J Physiol. 2019 09; 597(17):4533-4564. Kernik DC, Morotti S, Wu H, Garg P, Duff HJ, Kurokawa J, Jalife J, Wu JC, Grandi E, Clancy CE. PMID: 31278749; PMCID: PMC6767694.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    20. Different paths, same destination: divergent action potential responses produce conserved cardiac fight-or-flight response in mouse and rabbit hearts. J Physiol. 2019 08; 597(15):3867-3883. Wang L, Morotti S, Tapa S, Francis Stuart SD, Jiang Y, Wang Z, Myles RC, Brack KE, Ng GA, Bers DM, Grandi E, Ripplinger CM. PMID: 31215643; PMCID: PMC6675632.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    21. Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia. J Clin Invest. 2019 06 04; 129(8):3140-3152. Syed AU, Reddy GR, Ghosh D, Prada MP, Nystoriak MA, Morotti S, Grandi E, Sirish P, Chiamvimonvat N, Hell JW, Santana LF, Xiang YK, Nieves-Cintrón M, Navedo MF. PMID: 31162142; PMCID: PMC6668679.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    22. Enhanced Depolarization Drive in Failing Rabbit Ventricular Myocytes: Calcium-Dependent and β-Adrenergic Effects on Late Sodium, L-Type Calcium, and Sodium-Calcium Exchange Currents. Circ Arrhythm Electrophysiol. 2019 03; 12(3):e007061. Hegyi B, Morotti S, Liu C, Ginsburg KS, Bossuyt J, Belardinelli L, Izu LT, Chen-Izu Y, Bányász T, Grandi E, Bers DM. PMID: 30879336; PMCID: PMC6720130.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    23. A Heart for Diversity: Simulating Variability in Cardiac Arrhythmia Research. Front Physiol. 2018; 9:958. Ni H, Morotti S, Grandi E. PMID: 30079031; PMCID: PMC6062641.
      View in: PubMed   Mentions: 36  
    24. Quantitative systems models illuminate arrhythmia mechanisms in heart failure: Role of the Na+ -Ca2+ -Ca2+ /calmodulin-dependent protein kinase II-reactive oxygen species feedback. Wiley Interdiscip Rev Syst Biol Med. 2019 03; 11(2):e1434. Morotti S, Grandi E. PMID: 30015404; PMCID: PMC6336536.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    25. Editorial: Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond. Front Physiol. 2018; 9:678. Grandi E, Morotti S, Pueyo E, Rodriguez B. PMID: 29937733; PMCID: PMC6003136.
      View in: PubMed   Mentions: 6  
    26. Inward Rectifier Potassium Channels (Kir2.x) and Caveolin-3 Domain-Specific Interaction: Implications for Purkinje Cell-Dependent Ventricular Arrhythmias. Circ Arrhythm Electrophysiol. 2018 01; 11(1):e005800. Vaidyanathan R, Van Ert H, Haq KT, Morotti S, Esch S, McCune EC, Grandi E, Eckhardt LL. PMID: 29326130; PMCID: PMC5771420.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    27. In Silico Assessment of Efficacy and Safety of IKur Inhibitors in Chronic Atrial Fibrillation: Role of Kinetics and State-Dependence of Drug Binding. Front Pharmacol. 2017; 8:799. Ellinwood N, Dobrev D, Morotti S, Grandi E. PMID: 29163179; PMCID: PMC5681918.
      View in: PubMed   Mentions: 15  
    28. Erratum: "Revealing kinetics and state-dependent binding properties of IKur-targeting drugs that maximize atrial fibrillation selectivity" [Chaos 27, 093918 (2017)]. Chaos. 2017 10; 27(10):109902. Ellinwood N, Dobrev D, Morotti S, Grandi E. PMID: 29092428; PMCID: PMC6910595.
      View in: PubMed   Mentions: 3     Fields:    
    29. Revealing kinetics and state-dependent binding properties of IKur-targeting drugs that maximize atrial fibrillation selectivity. Chaos. 2017 Sep; 27(9):093918. Ellinwood N, Dobrev D, Morotti S, Grandi E. PMID: 28964116; PMCID: PMC5573366.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    30. FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility. Nat Commun. 2017 04 20; 8:15031. Surdo NC, Berrera M, Koschinski A, Brescia M, Machado MR, Carr C, Wright P, Gorelik J, Morotti S, Grandi E, Bers DM, Pantano S, Zaccolo M. PMID: 28425435; PMCID: PMC5411486.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    31. Quantitative analysis of the Ca2+ -dependent regulation of delayed rectifier K+ current IKs in rabbit ventricular myocytes. J Physiol. 2017 04 01; 595(7):2253-2268. Bartos DC, Morotti S, Ginsburg KS, Grandi E, Bers DM. PMID: 28008618; PMCID: PMC5374113.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    32. Predominant contribution of L-type Cav1.2 channel stimulation to impaired intracellular calcium and cerebral artery vasoconstriction in diabetic hyperglycemia. Channels (Austin). 2017 Jul 04; 11(4):340-346. Morotti S, Nieves-Cintrón M, Nystoriak MA, Navedo MF, Grandi E. PMID: 28631947; PMCID: PMC5555263.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    33. Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes. Sci Signal. 2017 01 24; 10(463). Nystoriak MA, Nieves-Cintrón M, Patriarchi T, Buonarati OR, Prada MP, Morotti S, Grandi E, Fernandes JD, Forbush K, Hofmann F, Sasse KC, Scott JD, Ward SM, Hell JW, Navedo MF. PMID: 28119464; PMCID: PMC5297430.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    34. Logistic regression analysis of populations of electrophysiological models to assess proarrythmic risk. MethodsX. 2017; 4:25-34. Morotti S, Grandi E. PMID: 28116246; PMCID: PMC5225282.
      View in: PubMed   Mentions: 35  
    35. Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes. J Mol Cell Cardiol. 2016 07; 96:63-71. Morotti S, McCulloch AD, Bers DM, Edwards AG, Grandi E. PMID: 26241847; PMCID: PMC4734906.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    36. β-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model. J Mol Cell Cardiol. 2015 Apr; 81:162-75. Negroni JA, Morotti S, Lascano EC, Gomes AV, Grandi E, Puglisi JL, Bers DM. PMID: 25724724; PMCID: PMC4380575.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    37. Ca(2+) current facilitation is CaMKII-dependent and has arrhythmogenic consequences. Front Pharmacol. 2014; 5:144. Bers DM, Morotti S. PMID: 24987371; PMCID: PMC4060732.
      View in: PubMed   Mentions: 29  
    38. A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII. J Physiol. 2014 Mar 15; 592(6):1181-97. Morotti S, Edwards AG, McCulloch AD, Bers DM, Grandi E. PMID: 24421356; PMCID: PMC3961080.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    39. Theoretical study of L-type Ca(2+) current inactivation kinetics during action potential repolarization and early afterdepolarizations. J Physiol. 2012 Sep 15; 590(18):4465-81. Morotti S, Grandi E, Summa A, Ginsburg KS, Bers DM. PMID: 22586219; PMCID: PMC3477752.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    40. Trafficking defects and gating abnormalities of a novel SCN5A mutation question gene-specific therapy in long QT syndrome type 3. Circ Res. 2010 Apr 30; 106(8):1374-83. Ruan Y, Denegri M, Liu N, Bachetti T, Seregni M, Morotti S, Severi S, Napolitano C, Priori SG. PMID: 20339117.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    41. Interplay of voltage and Ca-dependent inactivation of L-type Ca current. Prog Biophys Mol Biol. 2010 Sep; 103(1):44-50. Grandi E, Morotti S, Ginsburg KS, Severi S, Bers DM. PMID: 20184915; PMCID: PMC2907421.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals