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α1-Adrenergic receptor-PKC-Pyk2-Src signaling boosts L-type Ca2+ channel CaV1.2 activity and long-term potentiation in rodents. Elife. 2023 Jun 20; 12.
Man KNM, Bartels P, Henderson PB, Kim K, Shi M, Zhang M, Ho SY, Nieves-Cintron M, Navedo MF, Horne MC, Hell JW. PMID: 37338965; PMCID: PMC10325713.
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1 Fields:
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AnimalsCells
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Acute phosphatidylinositol 4,5 bisphosphate depletion destabilizes sarcolemmal expression of cardiac L-type Ca2+ channel CaV1.2. Proc Natl Acad Sci U S A. 2023 04 04; 120(14):e2221242120.
Voelker TL, Del Villar SG, Westhoff M, Costa AD, Coleman AM, Hell JW, Horne MC, Dickson EJ, Dixon RE. PMID: 36976770; PMCID: PMC10083594.
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2 Fields:
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Cells
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Half-calcified calmodulin promotes basal activity and inactivation of the L-type calcium channel CaV1.2. J Biol Chem. 2022 12; 298(12):102701.
Bartels P, Salveson I, Coleman AM, Anderson DE, Jeng G, Estrada-Tobar ZM, Man KNM, Yu Q, Kuzmenkina E, Nieves-Cintron M, Navedo MF, Horne MC, Hell JW, Ames JB. PMID: 36395884; PMCID: PMC9764201.
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4 Fields:
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Cells
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Tissue-specific adrenergic regulation of the L-type Ca2+ channel CaV1.2. Sci Signal. 2020 12 22; 13(663).
Man KNM, Bartels P, Horne MC, Hell JW. PMID: 33443233; PMCID: PMC7909005.
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10 Fields:
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HumansAnimalsCells
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α-Actinin-1 promotes activity of the L-type Ca2+ channel Cav1.2. EMBO J. 2020 Sep 15; 39(18):e106171.
Turner M, Anderson DE, Bartels P, Nieves-Cintron M, Coleman AM, Henderson PB, Man KNM, Tseng PY, Yarov-Yarovoy V, Bers DM, Navedo MF, Horne MC, Ames JB, Hell JW. PMID: 33433005; PMCID: PMC7507692.
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2 Fields:
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α-Actinin-1 promotes activity of the L-type Ca2+ channel Cav 1.2. EMBO J. 2020 03 02; 39(5):e102622.
Turner M, Anderson DE, Bartels P, Nieves-Cintron M, Coleman AM, Henderson PB, Man KNM, Tseng PY, Yarov-Yarovoy V, Bers DM, Navedo MF, Horne MC, Ames JB, Hell JW. PMID: 31985069; PMCID: PMC7049811.
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14 Fields:
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HumansCells
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β2 Adrenergic Receptor Complexes with the L-Type Ca2+ Channel CaV1.2 and AMPA-Type Glutamate Receptors: Paradigms for Pharmacological Targeting of Protein Interactions. Annu Rev Pharmacol Toxicol. 2020 01 06; 60:155-174.
Man KNM, Navedo MF, Horne MC, Hell JW. PMID: 31561738; PMCID: PMC7029424.
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9 Fields:
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HumansAnimalsCells
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Dynamic L-type CaV1.2 channel trafficking facilitates CaV1.2 clustering and cooperative gating. Biochim Biophys Acta Mol Cell Res. 2018 09; 1865(9):1341-1355.
Ghosh D, Nieves-Cintrón M, Tajada S, Brust-Mascher I, Horne MC, Hell JW, Dixon RE, Santana LF, Navedo MF. PMID: 29959960; PMCID: PMC6407617.
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PubMed Mentions:
20 Fields:
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HumansCells
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α-Actinin Anchors PSD-95 at Postsynaptic Sites. Neuron. 2018 03 07; 97(5):1094-1109.e9.
Matt L, Kim K, Hergarden AC, Patriarchi T, Malik ZA, Park DK, Chowdhury D, Buonarati OR, Henderson PB, Gökçek Saraç Ç, Zhang Y, Mohapatra D, Horne MC, Ames JB, Hell JW. PMID: 29429936; PMCID: PMC5963734.
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29 Fields:
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HumansAnimalsCells
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Proteolytic processing of the L-type Ca 2+ channel alpha 11.2 subunit in neurons. F1000Res. 2017; 6:1166.
Buonarati OR, Henderson PB, Murphy GG, Horne MC, Hell JW. PMID: 28781760; PMCID: PMC5531164.
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15 Fields:
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α-Actinin Promotes Surface Localization and Current Density of the Ca2+ Channel CaV1.2 by Binding to the IQ Region of the α1 Subunit. Biochemistry. 2017 07 18; 56(28):3669-3681.
Tseng PY, Henderson PB, Hergarden AC, Patriarchi T, Coleman AM, Lillya MW, Montagut-Bordas C, Lee B, Hell JW, Horne MC. PMID: 28613835; PMCID: PMC5704914.
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13 Fields:
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HumansAnimalsCells
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Angiotensin II signalling kicks out p27Kip1 : casein kinase 2 augmentation of Cav 1.2 L-type Ca2+ channel activity in immature ventricular cardiomyocytes. J Physiol. 2017 07 01; 595(13):4131-4132.
Horne MC, Hell JW. PMID: 28488737; PMCID: PMC5491853.
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1 Fields:
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Cells
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Cyclin G2 promotes cell cycle arrest in breast cancer cells responding to fulvestrant and metformin and correlates with patient survival. Cell Cycle. 2016 Dec; 15(23):3278-3295.
Zimmermann M, Arachchige-Don AP, Donaldson MS, Patriarchi T, Horne MC. PMID: 27753529; PMCID: PMC5176157.
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22 Fields:
Translation:
HumansCells
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Down-regulation of cyclin G2 by insulin, IGF-I (insulin-like growth factor 1) and X10 (AspB10 insulin): role in mitogenesis. Biochem J. 2014 Jan 01; 457(1):69-77.
Svendsen AM, Winge SB, Zimmermann M, Lindvig AB, Warzecha CB, Sajid W, Horne MC, De Meyts P. PMID: 24059861.
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8 Fields:
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HumansCells
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Elevated cyclin G2 expression intersects with DNA damage checkpoint signaling and is required for a potent G2/M checkpoint arrest response to doxorubicin. J Biol Chem. 2012 Jun 29; 287(27):22838-53.
Zimmermann M, Arachchige-Don AS, Donaldson MS, Dallapiazza RF, Cowan CE, Horne MC. PMID: 22589537; PMCID: PMC3391138.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Targeting of protein phosphatases PP2A and PP2B to the C-terminus of the L-type calcium channel Ca v1.2. Biochemistry. 2010 Dec 07; 49(48):10298-307.
Xu H, Ginsburg KS, Hall DD, Zimmermann M, Stein IS, Zhang M, Tandan S, Hill JA, Horne MC, Bers D, Hell JW. PMID: 21053940; PMCID: PMC3075818.
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27 Fields:
Translation:
AnimalsCells
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mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):7840-5.
Zhou J, Su P, Wang L, Chen J, Zimmermann M, Genbacev O, Afonja O, Horne MC, Tanaka T, Duan E, Fisher SJ, Liao J, Chen J, Wang F. PMID: 19416884; PMCID: PMC2683106.
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113 Fields:
Translation:
HumansCells
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Roles of human epidermal growth factor receptor 2, c-jun NH2-terminal kinase, phosphoinositide 3-kinase, and p70 S6 kinase pathways in regulation of cyclin G2 expression in human breast cancer cells. Mol Cancer Ther. 2007 Nov; 6(11):2843-57.
Le XF, Arachchige-Don AS, Mao W, Horne MC, Bast RC. PMID: 18025271.
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26 Fields:
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HumansAnimalsCells
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Chromosomal instability and supernumerary centrosomes represent precursor defects in a mouse model of T-cell lymphoma. Cancer Res. 2007 Sep 01; 67(17):8081-8.
van de Wetering CI, Horne MC, Knudson CM. PMID: 17804719.
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9 Fields:
Translation:
AnimalsCells
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Cyclin G2 is a centrosome-associated nucleocytoplasmic shuttling protein that influences microtubule stability and induces a p53-dependent cell cycle arrest. Exp Cell Res. 2006 Dec 10; 312(20):4181-204.
Arachchige Don AS, Dallapiazza RF, Bennin DA, Brake T, Cowan CE, Horne MC. PMID: 17123511; PMCID: PMC1862360.
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41 Fields:
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HumansCells
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Binding of protein phosphatase 2A to the L-type calcium channel Cav1.2 next to Ser1928, its main PKA site, is critical for Ser1928 dephosphorylation. Biochemistry. 2006 Mar 14; 45(10):3448-59.
Hall DD, Feekes JA, Arachchige Don AS, Shi M, Hamid J, Chen L, Strack S, Zamponi GW, Horne MC, Hell JW. PMID: 16519540.
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61 Fields:
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AnimalsCells
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Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways. Mol Cancer Res. 2003 Jan; 1(3):195-206.
Zhao L, Samuels T, Winckler S, Korgaonkar C, Tompkins V, Horne MC, Quelle DE. PMID: 12556559.
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50 Fields:
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HumansAnimalsCells
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Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest. J Biol Chem. 2002 Jul 26; 277(30):27449-67.
Bennin DA, Don AS, Brake T, McKenzie JL, Rosenbaum H, Ortiz L, DePaoli-Roach AA, Horne MC. PMID: 11956189.
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95 Fields:
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HumansAnimalsCells
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A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2. Science. 2001 Jul 06; 293(5527):98-101.
Davare MA, Avdonin V, Hall DD, Peden EM, Burette A, Weinberg RJ, Horne MC, Hoshi T, Hell JW. PMID: 11441182.
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195 Fields:
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HumansAnimalsCells
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Protein phosphatase 2A is associated with class C L-type calcium channels (Cav1.2) and antagonizes channel phosphorylation by cAMP-dependent protein kinase. J Biol Chem. 2000 Dec 15; 275(50):39710-7.
Davare MA, Horne MC, Hell JW. PMID: 10984483.
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70 Fields:
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HumansAnimalsCells
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Calcium/calmodulin-dependent protein kinase II is associated with the N-methyl-D-aspartate receptor. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):3239-44.
Leonard AS, Lim IA, Hemsworth DE, Horne MC, Hell JW. PMID: 10077668; PMCID: PMC15926.
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149 Fields:
Translation:
AnimalsCells
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SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit. J Biol Chem. 1998 Jul 31; 273(31):19518-24.
Leonard AS, Davare MA, Horne MC, Garner CC, Hell JW. PMID: 9677374.
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148 Fields:
Translation:
AnimalsCells
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Cyclin G2 is up-regulated during growth inhibition and B cell antigen receptor-mediated cell cycle arrest. J Biol Chem. 1997 May 09; 272(19):12650-61.
Horne MC, Donaldson KL, Goolsby GL, Tran D, Mulheisen M, Hell JW, Wahl AF. PMID: 9139721.
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49 Fields:
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HumansAnimalsCells
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Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression. J Biol Chem. 1996 Mar 15; 271(11):6050-61.
Horne MC, Goolsby GL, Donaldson KL, Tran D, Neubauer M, Wahl AF. PMID: 8626390.
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54 Fields:
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HumansAnimalsCells
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Assembly of the truncated immunoglobulin heavy chain D mu into antigen receptor-like complexes in pre-B cells but not in B cells. Immunity. 1996 Feb; 4(2):145-58.
Horne MC, Roth PE, DeFranco AL. PMID: 8624805.
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8 Fields:
Translation:
AnimalsCells
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Heterologous in vitro transcription from two archaebacterial promoters. FEBS Lett. 1991 Jul 22; 285(2):257-9.
Hüdepohl U, Gropp F, Horne M, Zillig W. PMID: 1906812.
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3 Fields:
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Cells
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A DNA region of 9 kbp contains all genes necessary for gas vesicle synthesis in halophilic archaebacteria. Mol Microbiol. 1991 May; 5(5):1159-74.
Horne M, Englert C, Wimmer C, Pfeifer F. PMID: 1956294.
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20 Fields:
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Cells
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Expression of the major gas vesicle protein gene in the halophilic archaebacterium Haloferax mediterranei is modulated by salt. Mol Gen Genet. 1990 Jul; 222(2-3):225-32.
Englert C, Horne M, Pfeifer F. PMID: 1703266.
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23 Fields:
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Cells
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Expression of two gas vacuole protein genes in Halobacterium halobium and other related species. Mol Gen Genet. 1989 Sep; 218(3):437-44.
Horne M, Pfeifer F. PMID: 2586485.
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16 Fields:
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Cells
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Genome structure of Halobacterium halobium: plasmid dynamics in gas vacuole deficient mutants. Can J Microbiol. 1989 Jan; 35(1):96-100.
Pfeifer F, Blaseio U, Horne M. PMID: 2541880.
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7 Fields:
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Cells
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Two genes encoding gas vacuole proteins in Halobacterium halobium. Mol Gen Genet. 1988 Aug; 213(2-3):459-64.
Horne M, Englert C, Pfeifer F. PMID: 3185512.
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23 Fields:
Translation:
Cells