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Manuel F Navedo

Title(s)Associate Professor, Pharmacology
SchoolUniversity of California, Davis
Phone530-752-6880
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    Coupling of Vascular Cav1.2 Channels In Health & Disease
    NIH/NHLBI R01HL121059Jul 1, 2015 - Apr 30, 2019
    Role: Principal Investigator
    Calcium Sparklers-Induced Vascular Dysfunction During Diabetes
    NIH/NHLBI R01HL098200Jul 19, 2010 - May 31, 2020
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Shen A, Chen D, Kaur M, Bartels P, Xu B, Shi Q, Martinez JM, Man KM, Nieves-Cintron M, Hell JW, Navedo MF, Yu XY, Xiang YK. ß-blockers augment L-type Ca2+ channel activity by targeting spatially restricted ß2AR signaling in neurons. Elife. 2019 Oct 14; 8. PMID: 31609201.
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    2. Man KNM, Navedo MF, Horne MC, Hell JW. ß2 Adrenergic Receptor Complexes with the L-Type Ca2+ Channel CaV1.2 and AMPA-Type Glutamate Receptors: Paradigms for Pharmacological Targeting of Protein Interactions. Annu Rev Pharmacol Toxicol. 2019 Sep 27. PMID: 31561738.
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    3. Sato D, Hernández-Hernández G, Matsumoto C, Tajada S, Moreno CM, Dixon RE, O'Dwyer S, Navedo MF, Trimmer JS, Clancy CE, Binder MD, Santana LF. A stochastic model of ion channel cluster formation in the plasma membrane. J Gen Physiol. 2019 Sep 02; 151(9):1116-1134. PMID: 31371391.
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    4. Syed AU, Reddy GR, Ghosh D, Prada MP, Nystoriak MA, Morotti S, Grandi E, Sirish P, Chiamvimonvat N, Hell JW, Santana LF, Xiang YK, Nieves-Cintrón M, Navedo MF. Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia. J Clin Invest. 2019 06 04; 129(8):3140-3152. PMID: 31162142.
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    5. Ito DW, Hannigan KI, Ghosh D, Xu B, Del Villar SG, Xiang YK, Dickson EJ, Navedo MF, Dixon RE. ß-adrenergic-mediated dynamic augmentation of sarcolemmal CaV 1.2 clustering and co-operativity in ventricular myocytes. J Physiol. 2019 Apr; 597(8):2139-2162. PMID: 30714156.
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    6. Prada MP, Syed AU, Buonarati OR, Reddy GR, Nystoriak MA, Ghosh D, Simó S, Sato D, Sasse KC, Ward SM, Santana LF, Xiang YK, Hell JW, Nieves-Cintrón M, Navedo MF. A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia. Elife. 2019 Mar 01; 8. PMID: 30821687.
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    7. Smith FD, Omar MH, Nygren PJ, Soughayer J, Hoshi N, Lau HT, Snyder CG, Branon TC, Ghosh D, Langeberg LK, Ting AY, Santana LF, Ong SE, Navedo MF, Scott JD. Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins. Proc Natl Acad Sci U S A. 2018 12 04; 115(49):E11465-E11474. PMID: 30455320.
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    8. Ghosh D, Nieves-Cintrón M, Tajada S, Brust-Mascher I, Horne MC, Hell JW, Dixon RE, Santana LF, Navedo MF. Dynamic L-type CaV1.2 channel trafficking facilitates CaV1.2 clustering and cooperative gating. Biochim Biophys Acta Mol Cell Res. 2018 09; 1865(9):1341-1355. PMID: 29959960.
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    9. Shen Y, Pfluger T, Ferreira F, Liang J, Navedo MF, Zeng Q, Reid B, Zhao M. Corrigendum: Diabetic cornea wounds produce significantly weaker electric signals that may contribute to impaired healing. Sci Rep. 2018 Jun 27; 8:46997. PMID: 29947346.
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    10. Shen A, Nieves-Cintron M, Deng Y, Shi Q, Chowdhury D, Qi J, Hell JW, Navedo MF, Xiang YK. Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell. Nat Commun. 2018 03 13; 9(1):1050. PMID: 29535304.
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    11. Navedo MF, Amberg GC. Going with the flow: contextual fine-tuning of vascular reactivity. J Physiol. 2018 04 01; 596(7):1127-1128. PMID: 29427447.
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    12. Sato D, Dixon RE, Santana LF, Navedo MF. A model for cooperative gating of L-type Ca2+ channels and its effects on cardiac alternans dynamics. PLoS Comput Biol. 2018 01; 14(1):e1005906. PMID: 29338006.
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    13. Nieves-Cintrón M, Syed AU, Nystoriak MA, Navedo MF. Regulation of voltage-gated potassium channels in vascular smooth muscle during hypertension and metabolic disorders. Microcirculation. 2018 01; 25(1). PMID: 29044853.
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    14. Dwenger MM, Ohanyan V, Navedo MF, Nystoriak MA. Coronary microvascular Kv1 channels as regulatory sensors of intracellular pyridine nucleotide redox potential. Microcirculation. 2018 01; 25(1). PMID: 29110409.
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    15. Nystoriak MA, Navedo MF. Regulation of microvascular function by voltage-gated potassium channels: New tricks for an "ancient" dog. Microcirculation. 2018 01; 25(1). PMID: 29239491.
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    16. Nieves-Cintrón M, Syed AU, Buonarati OR, Rigor RR, Nystoriak MA, Ghosh D, Sasse KC, Ward SM, Santana LF, Hell JW, Navedo MF. Impaired BKCa channel function in native vascular smooth muscle from humans with type 2 diabetes. Sci Rep. 2017 10 25; 7(1):14058. PMID: 29070899.
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    17. Tajada S, Moreno CM, O'Dwyer S, Woods S, Sato D, Navedo MF, Santana LF. Distance constraints on activation of TRPV4 channels by AKAP150-bound PKCa in arterial myocytes. J Gen Physiol. 2017 Jun 05; 149(6):639-659. PMID: 28507079.
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    18. Morotti S, Nieves-Cintrón M, Nystoriak MA, Navedo MF, Grandi E. Predominant contribution of L-type Cav1.2 channel stimulation to impaired intracellular calcium and cerebral artery vasoconstriction in diabetic hyperglycemia. Channels (Austin). 2017 Jul 04; 11(4):340-346. PMID: 28631947.
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    19. Hell JW, Navedo MF, VanHook AM. Science Signaling Podcast for 24 January 2017: Tissue-specific regulation of L-type calcium channels. Sci Signal. 2017 01 24; 10(463). PMID: 28119457.
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    20. Qian H, Patriarchi T, Price JL, Matt L, Lee B, Nieves-Cintrón M, Buonarati OR, Chowdhury D, Nanou E, Nystoriak MA, Catterall WA, Poomvanicha M, Hofmann F, Navedo MF, Hell JW. Phosphorylation of Ser1928 mediates the enhanced activity of the L-type Ca2+ channel Cav1.2 by the ß2-adrenergic receptor in neurons. Sci Signal. 2017 01 24; 10(463). PMID: 28119465.
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    21. Nystoriak MA, Nieves-Cintrón M, Patriarchi T, Buonarati OR, Prada MP, Morotti S, Grandi E, Fernandes JD, Forbush K, Hofmann F, Sasse KC, Scott JD, Ward SM, Hell JW, Navedo MF. Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes. Sci Signal. 2017 01 24; 10(463). PMID: 28119464.
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    22. Grandi E, Sanguinetti MC, Bartos DC, Bers DM, Chen-Izu Y, Chiamvimonvat N, Colecraft HM, Delisle BP, Heijman J, Navedo MF, Noskov S, Proenza C, Vandenberg JI, Yarov-Yarovoy V. Potassium channels in the heart: structure, function and regulation. J Physiol. 2017 04 01; 595(7):2209-2228. PMID: 27861921.
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    23. Ghosh D, Syed AU, Prada MP, Nystoriak MA, Santana LF, Nieves-Cintrón M, Navedo MF. Calcium Channels in Vascular Smooth Muscle. Adv Pharmacol. 2017; 78:49-87. PMID: 28212803.
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    24. Shen Y, Pfluger T, Ferreira F, Liang J, Navedo MF, Zeng Q, Reid B, Zhao M. Diabetic cornea wounds produce significantly weaker electric signals that may contribute to impaired healing. Sci Rep. 2016 06 10; 6:26525. PMID: 27283241.
      View in: PubMed
    25. Patriarchi T, Qian H, Di Biase V, Malik ZA, Chowdhury D, Price JL, Hammes EA, Buonarati OR, Westenbroek RE, Catterall WA, Hofmann F, Xiang YK, Murphy GG, Chen CY, Navedo MF, Hell JW. Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the ß2 adrenergic receptor. EMBO J. 2016 06 15; 35(12):1330-45. PMID: 27103070.
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    26. Nieves-Cintrón M, Nystoriak MA, Prada MP, Johnson K, Fayer W, Dell'Acqua ML, Scott JD, Navedo MF. Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes. J Biol Chem. 2016 Mar 04; 291(10):4912. PMID: 26945093.
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    27. Nieves-Cintrón M, Hirenallur-Shanthappa D, Nygren PJ, Hinke SA, Dell'Acqua ML, Langeberg LK, Navedo M, Santana LF, Scott JD. AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K(+) currents in ventricular myocytes following myocardial infarction. Cell Signal. 2016 07; 28(7):733-40. PMID: 26724383.
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    28. Chaplin NL, Nieves-Cintrón M, Fresquez AM, Navedo MF, Amberg GC. Arterial Smooth Muscle Mitochondria Amplify Hydrogen Peroxide Microdomains Functionally Coupled to L-Type Calcium Channels. Circ Res. 2015 Dec 04; 117(12):1013-23. PMID: 26390880.
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    29. Dixon RE, Moreno CM, Yuan C, Opitz-Araya X, Binder MD, Navedo MF, Santana LF. Graded Ca²?/calmodulin-dependent coupling of voltage-gated CaV1.2 channels. Elife. 2015 Feb 25; 4. PMID: 25714924.
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    30. Nieves-Cintrón M, Nystoriak MA, Prada MP, Johnson K, Fayer W, Dell'Acqua ML, Scott JD, Navedo MF. Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes. J Biol Chem. 2015 Mar 20; 290(12):7918-29. PMID: 25670860.
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    31. Malik ZA, Stein IS, Navedo MF, Hell JW. Mission CaMKII?: shuttle calmodulin from membrane to nucleus. Cell. 2014 Oct 09; 159(2):235-7. PMID: 25303520.
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    32. Navedo MF, Hell JW. AKAP5 keeps L-type channels and NFAT on their toes. Cell Rep. 2014 Jun 12; 7(5):1341-1342. PMID: 24926793.
      View in: PubMed
    33. Mercado J, Baylie R, Navedo MF, Yuan C, Scott JD, Nelson MT, Brayden JE, Santana LF. Local control of TRPV4 channels by AKAP150-targeted PKC in arterial smooth muscle. J Gen Physiol. 2014 May; 143(5):559-75. PMID: 24778429.
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    34. Nystoriak MA, Nieves-Cintrón M, Nygren PJ, Hinke SA, Nichols CB, Chen CY, Puglisi JL, Izu LT, Bers DM, Dell'acqua ML, Scott JD, Santana LF, Navedo MF. AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus. Circ Res. 2014 Feb 14; 114(4):607-15. PMID: 24323672.
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    35. Gulia J, Navedo MF, Gui P, Chao JT, Mercado JL, Santana LF, Davis MJ. Regulation of L-type calcium channel sparklet activity by c-Src and PKC-a. Am J Physiol Cell Physiol. 2013 Sep; 305(5):C568-77. PMID: 23804206.
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    36. Navedo MF, Amberg GC. Local regulation of L-type Ca²? channel sparklets in arterial smooth muscle. Microcirculation. 2013 May; 20(4):290-8. PMID: 23116449.
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    37. Amberg GC, Navedo MF. Calcium dynamics in vascular smooth muscle. Microcirculation. 2013 May; 20(4):281-9. PMID: 23384444.
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    38. Navedo MF, Santana LF. CaV1.2 sparklets in heart and vascular smooth muscle. J Mol Cell Cardiol. 2013 May; 58:67-76. PMID: 23220157.
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    39. Nystoriak MA, Nieves-Cintrón M, Navedo MF. Capturing single L-type Ca(2+) channel function with optics. Biochim Biophys Acta. 2013 Jul; 1833(7):1657-64. PMID: 23124113.
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    40. Hinke SA, Navedo MF, Ulman A, Whiting JL, Nygren PJ, Tian G, Jimenez-Caliani AJ, Langeberg LK, Cirulli V, Tengholm A, Dell'Acqua ML, Santana LF, Scott JD. Anchored phosphatases modulate glucose homeostasis. EMBO J. 2012 Oct 17; 31(20):3991-4004. PMID: 22940692.
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    41. Dixon RE, Yuan C, Cheng EP, Navedo MF, Santana LF. Ca2+ signaling amplification by oligomerization of L-type Cav1.2 channels. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):1749-54. PMID: 22307641.
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    42. Takeda Y, Nystoriak MA, Nieves-Cintrón M, Santana LF, Navedo MF. Relationship between Ca2+ sparklets and sarcoplasmic reticulum Ca2+ load and release in rat cerebral arterial smooth muscle. Am J Physiol Heart Circ Physiol. 2011 Dec; 301(6):H2285-94. PMID: 21984539.
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    43. Cheng EP, Yuan C, Navedo MF, Dixon RE, Nieves-Cintrón M, Scott JD, Santana LF. Restoration of normal L-type Ca2+ channel function during Timothy syndrome by ablation of an anchoring protein. Circ Res. 2011 Jul 22; 109(3):255-61. PMID: 21700933.
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    44. Santana LF, Navedo MF. Natural inequalities: why some L-type Ca2+ channels work harder than others. J Gen Physiol. 2010 Aug; 136(2):143-7. PMID: 20660657.
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    45. Nichols CB, Rossow CF, Navedo MF, Westenbroek RE, Catterall WA, Santana LF, McKnight GS. Sympathetic stimulation of adult cardiomyocytes requires association of AKAP5 with a subpopulation of L-type calcium channels. Circ Res. 2010 Sep 17; 107(6):747-56. PMID: 20671242.
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    46. Zhang J, Ren C, Chen L, Navedo MF, Antos LK, Kinsey SP, Iwamoto T, Philipson KD, Kotlikoff MI, Santana LF, Wier WG, Matteson DR, Blaustein MP. Knockout of Na+/Ca2+ exchanger in smooth muscle attenuates vasoconstriction and L-type Ca2+ channel current and lowers blood pressure. Am J Physiol Heart Circ Physiol. 2010 May; 298(5):H1472-83. PMID: 20173044.
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    47. Navedo MF, Cheng EP, Yuan C, Votaw S, Molkentin JD, Scott JD, Santana LF. Increased coupled gating of L-type Ca2+ channels during hypertension and Timothy syndrome. Circ Res. 2010 Mar 05; 106(4):748-56. PMID: 20110531.
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    48. Navedo MF, Takeda Y, Nieves-Cintrón M, Molkentin JD, Santana LF. Elevated Ca2+ sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells. Am J Physiol Cell Physiol. 2010 Feb; 298(2):C211-20. PMID: 19846755.
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    49. Santana LF, Navedo MF. Molecular and biophysical mechanisms of Ca2+ sparklets in smooth muscle. J Mol Cell Cardiol. 2009 Oct; 47(4):436-44. PMID: 19616004.
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    50. Nieves-Cintrón M, Caballero-Rivera D, Silva WI, Navedo MF, Lasalde-Dominicci JA. Functional contribution of alpha3L8' to the neuronal nicotinic alpha3 receptor. J Neurosci Res. 2008 Oct; 86(13):2884-94. PMID: 18615639.
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    51. Nieves-Cintrón M, Amberg GC, Navedo MF, Molkentin JD, Santana LF. The control of Ca2+ influx and NFATc3 signaling in arterial smooth muscle during hypertension. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15623-8. PMID: 18832165.
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    52. Santana LF, Navedo MF, Amberg GC, Nieves-Cintrón M, Votaw VS, Ufret-Vincenty CA. Calcium sparklets in arterial smooth muscle. Clin Exp Pharmacol Physiol. 2008 Sep; 35(9):1121-6. PMID: 18215181.
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    53. Navedo MF, Nieves-Cintrón M, Amberg GC, Yuan C, Votaw VS, Lederer WJ, McKnight GS, Santana LF. AKAP150 is required for stuttering persistent Ca2+ sparklets and angiotensin II-induced hypertension. Circ Res. 2008 Feb 01; 102(2):e1-e11. PMID: 18174462.
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    54. Navedo MF, Amberg GC, Westenbroek RE, Sinnegger-Brauns MJ, Catterall WA, Striessnig J, Santana LF. Ca(v)1.3 channels produce persistent calcium sparklets, but Ca(v)1.2 channels are responsible for sparklets in mouse arterial smooth muscle. Am J Physiol Heart Circ Physiol. 2007 Sep; 293(3):H1359-70. PMID: 17526649.
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    55. Amberg GC, Navedo MF, Nieves-Cintrón M, Molkentin JD, Santana LF. Calcium sparklets regulate local and global calcium in murine arterial smooth muscle. J Physiol. 2007 Feb 15; 579(Pt 1):187-201. PMID: 17158168.
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    56. Nieves-Cintrón M, Caballero-Rivera D, Navedo MF, Lasalde-Dominicci JA. Contribution of valine 7' of TMD2 to gating of neuronal alpha3 receptor subtypes. J Neurosci Res. 2006 Dec; 84(8):1778-88. PMID: 17044037.
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    57. Navedo MF, Amberg GC, Nieves M, Molkentin JD, Santana LF. Mechanisms underlying heterogeneous Ca2+ sparklet activity in arterial smooth muscle. J Gen Physiol. 2006 Jun; 127(6):611-22. PMID: 16702354.
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    58. Navedo MF, Lasalde-Dominicci JA, Báez-Pagán CA, Díaz-Pérez L, Rojas LV, Maselli RA, Staub J, Schott K, Zayas R, Gomez CM. Novel beta subunit mutation causes a slow-channel syndrome by enhancing activation and decreasing the rate of agonist dissociation. Mol Cell Neurosci. 2006 May-Jun; 32(1-2):82-90. PMID: 16624571.
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    59. Amberg GC, Navedo MF, Santana LF. On the loose: uncaging Ca2+ -induced Ca2+ release in smooth muscle. J Gen Physiol. 2006 Mar; 127(3):221-3. PMID: 16505144.
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    60. Navedo MF, Amberg GC, Votaw VS, Santana LF. Constitutively active L-type Ca2+ channels. Proc Natl Acad Sci U S A. 2005 Aug 02; 102(31):11112-7. PMID: 16040810.
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    61. Amberg GC, Rossow CF, Navedo MF, Santana LF. NFATc3 regulates Kv2.1 expression in arterial smooth muscle. J Biol Chem. 2004 Nov 05; 279(45):47326-34. PMID: 15322114.
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    62. Navedo M, Nieves M, Rojas L, Lasalde-Dominicci JA. Tryptophan substitutions reveal the role of nicotinic acetylcholine receptor alpha-TM3 domain in channel gating: differences between Torpedo and muscle-type AChR. Biochemistry. 2004 Jan 13; 43(1):78-84. PMID: 14705933.
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    63. Gomez CM, Maselli RA, Vohra BP, Navedo M, Stiles JR, Charnet P, Schott K, Rojas L, Keesey J, Verity A, Wollmann RW, Lasalde-Dominicci J. Novel delta subunit mutation in slow-channel syndrome causes severe weakness by novel mechanisms. Ann Neurol. 2002 Jan; 51(1):102-12. PMID: 11782989.
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