Manuel F Navedo

Title(s)Professor, Med: Pharmacology
SchoolSchool of Medicine
AddressOne Shields Avenue MED: PHARM Tupper 2420
CA 95616
Phone530-752-6880
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    Coupling of Vascular Cav1.2 Channels In Health & Disease
    NIH/NHLBI R01HL121059Jul 1, 2015 - Apr 30, 2019
    Role: Principal Investigator
    Calcium Sparklers-Induced Vascular Dysfunction During Diabetes
    NIH/NHLBI R01HL098200Jul 19, 2010 - May 31, 2020
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Understanding Vascular Reactivity. Microcirculation. 2025 Apr; 32(3):e70008. Navedo MF, Earley S, Isakson BE. PMID: 40293184; PMCID: PMC12036497.
      View in: PubMed   Mentions:    Fields:    
    2. Electrifying the brain capillary Ca2+ signal. Proc Natl Acad Sci U S A. 2025 Jan 28; 122(4):e2425994122. Navedo MF, Nieves-Cintron M, Santana LF. PMID: 39835910; PMCID: PMC11789082.
      View in: PubMed   Mentions:    Fields:    
    3. The P2Y6 Receptor as a Potential Keystone in Essential Hypertension. Function (Oxf). 2024 Nov 20; 5(6). Daghbouche-Rubio N, Álvarez-Miguel I, Flores VA, Rojo-Mencía J, Navedo M, Nieves-Citrón M, Cidad P, Pérez-García MT, López-López JR. PMID: 39322240; PMCID: PMC11577605.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Rap1 Brings the A Game to Control Lung Endothelium. Arterioscler Thromb Vasc Biol. 2024 Nov; 44(11):2288-2290. Martín-Aragón Baudel M, Nieves-Cintrón M, Navedo MF. PMID: 39441913; PMCID: PMC11498902.
      View in: PubMed   Mentions:    Fields:    
    5. α1C S1928 Phosphorylation of CaV1.2 Channel Controls Vascular Reactivity and Blood Pressure. J Am Heart Assoc. 2024 Oct 15; 13(20):e035375. Flores-Tamez VA, Martín-Aragón Baudel M, Hong J, Taylor JL, Ren L, Le T, Syed AU, Moustafa Y, Singhrao N, Lemus-Martinez WR, Reddy GR, Ramer V, Man KNM, Bartels P, Chen-Izu Y, Chen CY, Simo S, Dickson EJ, Morotti S, Grandi E, Santana LF, Hell JW, Horne MC, Nieves-Cintrón M, Navedo MF. PMID: 39377203; PMCID: PMC11935578.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    6. Vascular Function and Ion Channels in Alzheimer's Disease. Microcirculation. 2024 10; 31(7):e12881. Taylor JL, Martin-Aragon Baudel M, Nieves-Cintron M, Navedo MF. PMID: 39190776; PMCID: PMC11498901.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    7. Nicotine Impairs Smooth Muscle cAMP Signaling and Vascular Reactivity. Microcirculation. 2024 08; 31(6):e12871. Singhrao N, Flores-Tamez VA, Moustafa YA, Reddy GR, Burns AE, Pinkerton KE, Chen CY, Navedo MF, Nieves-Cintrón M. PMID: 38805589; PMCID: PMC11303104.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    8. Sorbs2 Modulation of BK Channels in Arterial Myocytes: Implications for Diabetes. Circ Res. 2024 Mar 29; 134(7):872-874. Santana LF, Navedo MF. PMID: 38547252; PMCID: PMC10987049.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. Diabetic Ocular Surface Has Defects in Oxygen Uptake Revealed by Optic Fiber Microsensor. Invest Ophthalmol Vis Sci. 2024 Mar 05; 65(3):27. Qin S, Ma L, Ferreira F, Brown C, Navedo MF, Reid B, Zhao M. PMID: 38506851; PMCID: PMC10959196.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    10. SparkMaster 2: A New Software for Automatic Analysis of Calcium Spark Data. Circ Res. 2023 09; 133(6):450-462. Tomek J, Nieves-Cintron M, Navedo MF, Ko CY, Bers DM. PMID: 37555352; PMCID: PMC7615009.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    11. α1-Adrenergic receptor-PKC-Pyk2-Src signaling boosts L-type Ca2+ channel CaV1.2 activity and long-term potentiation in rodents. Elife. 2023 Jun 20; 12. Man KNM, Bartels P, Henderson PB, Kim K, Shi M, Zhang M, Ho SY, Nieves-Cintron M, Navedo MF, Horne MC, Hell JW. PMID: 37338965; PMCID: PMC10325713.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    12. Nitric oxide synthase and reduced arterial tone contribute to arteriovenous malformation. Sci Adv. 2023 05 26; 9(21):eade7280. Huang L, Cheng F, Zhang X, Zielonka J, Nystoriak MA, Xiang W, Raygor K, Wang S, Lakshmanan A, Jiang W, Yuan S, Hou KS, Zhang J, Wang X, Syed AU, Juric M, Takahashi T, Navedo MF, Wang RA. PMID: 37235659; PMCID: PMC10219588.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    13. Transfer of nuclear and ribosomal material from Sox10-lineage cells to neurons in the mouse brain. J Exp Med. 2023 07 03; 220(7). Mayrhofer F, Hanson AM, Navedo MF, Xiang YK, Soulika AM, Deng W, Chechneva OV. PMID: 37067791; PMCID: PMC10114922.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    14. Diversity of cells and signals in the cardiovascular system. J Physiol. 2023 07; 601(13):2547-2592. Grandi E, Navedo MF, Saucerman JJ, Bers DM, Chiamvimonvat N, Dixon RE, Dobrev D, Gomez AM, Harraz OF, Hegyi B, Jones DK, Krogh-Madsen T, Murfee WL, Nystoriak MA, Posnack NG, Ripplinger CM, Veeraraghavan R, Weinberg S. PMID: 36744541; PMCID: PMC10313794.
      View in: PubMed   Mentions: 4     Fields:    
    15. Whole-heart multiparametric optical imaging reveals sex-dependent heterogeneity in cAMP signaling and repolarization kinetics. Sci Adv. 2023 01 20; 9(3):eadd5799. Caldwell JL, Lee IJ, Ngo L, Wang L, Bahriz S, Xu B, Bers DM, Navedo MF, Bossuyt J, Xiang YK, Ripplinger CM. PMID: 36662864; PMCID: PMC9858506.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    16. Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas. Commun Biol. 2023 01 03; 6(1):2. Verma N, Velmurugan GV, Winford E, Coburn H, Kotiya D, Leibold N, Radulescu L, Despa S, Chen KC, Van Eldik LJ, Nelson PT, Wilcock DM, Jicha GA, Stowe AM, Goldstein LB, Powel DK, Walton JH, Navedo MF, Nystoriak MA, Murray AJ, Biessels GJ, Troakes C, Zetterberg H, Hardy J, Lashley T, Despa F. PMID: 36596993; PMCID: PMC9810597.
      View in: PubMed   Mentions: 11  
    17. Mechanisms of Vascular CaV1.2 Channel Regulation During Diabetic Hyperglycemia. Handb Exp Pharmacol. 2023; 279:41-58. Martín-Aragón Baudel M, Hong J, Hell JW, Nieves-Cintrón M, Navedo MF. PMID: 36598607.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    18. Editorial: Nanodomain regulation of muscle physiology and alterations in disease. Front Physiol. 2022; 13:1092304. Louch WE, Ullrich ND, Navedo MF, Macquaide N. PMID: 36523550; PMCID: PMC9745436.
      View in: PubMed   Mentions:
    19. Diabetes and Excess Aldosterone Promote Heart Failure With Preserved Ejection Fraction. J Am Heart Assoc. 2022 12 06; 11(23):e027164. Hegyi B, Mira Hernandez J, Ko CY, Hong J, Shen EY, Spencer ER, Smoliarchuk D, Navedo MF, Bers DM, Bossuyt J. PMID: 36416174; PMCID: PMC9851441.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    20. Adenylyl cyclase isoform 1 contributes to sinoatrial node automaticity via functional microdomains. JCI Insight. 2022 11 22; 7(22). Ren L, Thai PN, Gopireddy RR, Timofeyev V, Ledford HA, Woltz RL, Park S, Puglisi JL, Moreno CM, Santana LF, Conti AC, Kotlikoff MI, Xiang YK, Yarov-Yarovoy V, Zaccolo M, Zhang XD, Yamoah EN, Navedo MF, Chiamvimonvat N. PMID: 36509290; PMCID: PMC9746826.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    21. Half-calcified calmodulin promotes basal activity and inactivation of the L-type calcium channel CaV1.2. J Biol Chem. 2022 12; 298(12):102701. Bartels P, Salveson I, Coleman AM, Anderson DE, Jeng G, Estrada-Tobar ZM, Man KNM, Yu Q, Kuzmenkina E, Nieves-Cintron M, Navedo MF, Horne MC, Hell JW, Ames JB. PMID: 36395884; PMCID: PMC9764201.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    22. Spatiotemporal Control of Vascular CaV1.2 by α1C S1928 Phosphorylation. Circ Res. 2022 12 02; 131(12):1018-1033. Martín-Aragón Baudel M, Flores-Tamez VA, Hong J, Reddy GR, Maillard P, Burns AE, Man KNM, Sasse KC, Ward SM, Catterall WA, Bers DM, Hell JW, Nieves-Cintrón M, Navedo MF. PMID: 36345826; PMCID: PMC9722584.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    23. Vascular CaV1.2 channels in diabetes. Curr Top Membr. 2022; 90:65-93. Pereira da Silva EA, Martín-Aragón Baudel M, Hong J, Bartels P, Navedo MF, Nieves-Cintrón M. PMID: 36368875.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    24. Disruption of mitochondria-sarcoplasmic reticulum microdomain connectomics contributes to sinus node dysfunction in heart failure. Proc Natl Acad Sci U S A. 2022 09 06; 119(36):e2206708119. Ren L, Gopireddy RR, Perkins G, Zhang H, Timofeyev V, Lyu Y, Diloretto DA, Trinh P, Sirish P, Overton JL, Xu W, Grainger N, Xiang YK, Dedkova EN, Zhang XD, Yamoah EN, Navedo MF, Thai PN, Chiamvimonvat N. PMID: 36044551; PMCID: PMC9456763.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    25. Ion channel molecular complexes in vascular smooth muscle. Front Physiol. 2022; 13:999369. Pereira da Silva EA, Martín-Aragón Baudel M, Navedo MF, Nieves-Cintrón M. PMID: 36091375; PMCID: PMC9459047.
      View in: PubMed   Mentions: 8  
    26. Deciphering cellular signals in adult mouse sinoatrial node cells. iScience. 2022 Jan 21; 25(1):103693. Reddy GR, Ren L, Thai PN, Caldwell JL, Zaccolo M, Bossuyt J, Ripplinger CM, Xiang YK, Nieves-Cintrón M, Chiamvimonvat N, Navedo MF. PMID: 35036877; PMCID: PMC8749457.
      View in: PubMed   Mentions: 4  
    27. Mechanisms and physiological implications of cooperative gating of clustered ion channels. Physiol Rev. 2022 07 01; 102(3):1159-1210. Dixon RE, Navedo MF, Binder MD, Santana LF. PMID: 34927454; PMCID: PMC8934683.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    28. Genetically engineered mice for combinatorial cardiovascular optobiology. Elife. 2021 10 29; 10. Lee FK, Lee JC, Shui B, Reining S, Jibilian M, Small DM, Jones JS, Allan-Rahill NH, Lamont MR, Rizzo MA, Tajada S, Navedo MF, Santana LF, Nishimura N, Kotlikoff MI. PMID: 34711305; PMCID: PMC8555989.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    29. β-Adrenergic control of sarcolemmal CaV1.2 abundance by small GTPase Rab proteins. Proc Natl Acad Sci U S A. 2021 02 16; 118(7). Del Villar SG, Voelker TL, Westhoff M, Reddy GR, Spooner HC, Navedo MF, Dickson EJ, Dixon RE. PMID: 33558236; PMCID: PMC7896340.
      View in: PubMed   Mentions: 17     Fields:    
    30. Hyperglycemia regulates cardiac K+ channels via O-GlcNAc-CaMKII and NOX2-ROS-PKC pathways. Basic Res Cardiol. 2020 11 25; 115(6):71. Hegyi B, Borst JM, Bailey LRJ, Shen EY, Lucena AJ, Navedo MF, Bossuyt J, Bers DM. PMID: 33237428; PMCID: PMC8349245.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    31. AKAP5 complex facilitates purinergic modulation of vascular L-type Ca2+ channel CaV1.2. Nat Commun. 2020 10 20; 11(1):5303. Prada MP, Syed AU, Reddy GR, Martín-Aragón Baudel M, Flores-Tamez VA, Sasse KC, Ward SM, Sirish P, Chiamvimonvat N, Bartels P, Dickson EJ, Hell JW, Scott JD, Santana LF, Xiang YK, Navedo MF, Nieves-Cintrón M. PMID: 33082339; PMCID: PMC7575592.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    32. α-Actinin-1 promotes activity of the L-type Ca2+ channel Cav1.2. EMBO J. 2020 Sep 15; 39(18):e106171. Turner M, Anderson DE, Bartels P, Nieves-Cintron M, Coleman AM, Henderson PB, Man KNM, Tseng PY, Yarov-Yarovoy V, Bers DM, Navedo MF, Horne MC, Ames JB, Hell JW. PMID: 33433005; PMCID: PMC7507692.
      View in: PubMed   Mentions: 3     Fields:    
    33. Maladaptive response of arterial myocytes to chronic exposure to Ca2+ channel blockers. Proc Natl Acad Sci U S A. 2020 08 04; 117(31):18151-18153. O'Dwyer SC, Navedo MF, Santana LF. PMID: 32680960; PMCID: PMC7414083.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. Cellular and molecular effects of hyperglycemia on ion channels in vascular smooth muscle. Cell Mol Life Sci. 2021 Jan; 78(1):31-61. Nieves-Cintrón M, Flores-Tamez VA, Le T, Baudel MM, Navedo MF. PMID: 32594191; PMCID: PMC7765743.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    35. TRPML1ng on sparks. Sci Signal. 2020 06 23; 13(637). Nieves-Cintron M, Santana LF, Navedo MF. PMID: 32576679; PMCID: PMC7384335.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    36. Purinergic Signaling During Hyperglycemia in Vascular Smooth Muscle Cells. Front Endocrinol (Lausanne). 2020; 11:329. Martin-Aragon Baudel M, Espinosa-Tanguma R, Nieves-Cintron M, Navedo MF. PMID: 32528416; PMCID: PMC7256624.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    37. α-Actinin-1 promotes activity of the L-type Ca2+ channel Cav 1.2. EMBO J. 2020 03 02; 39(5):e102622. Turner M, Anderson DE, Bartels P, Nieves-Cintron M, Coleman AM, Henderson PB, Man KNM, Tseng PY, Yarov-Yarovoy V, Bers DM, Navedo MF, Horne MC, Ames JB, Hell JW. PMID: 31985069; PMCID: PMC7049811.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    38. β-blockers augment L-type Ca2+ channel activity by targeting spatially restricted β2AR signaling in neurons. Elife. 2019 10 14; 8. Shen A, Chen D, Kaur M, Bartels P, Xu B, Shi Q, Martinez JM, Man KM, Nieves-Cintron M, Hell JW, Navedo MF, Yu XY, Xiang YK. PMID: 31609201; PMCID: PMC6813027.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    39. β2 Adrenergic Receptor Complexes with the L-Type Ca2+ Channel CaV1.2 and AMPA-Type Glutamate Receptors: Paradigms for Pharmacological Targeting of Protein Interactions. Annu Rev Pharmacol Toxicol. 2020 01 06; 60:155-174. Man KNM, Navedo MF, Horne MC, Hell JW. PMID: 31561738; PMCID: PMC7029424.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    40. A stochastic model of ion channel cluster formation in the plasma membrane. J Gen Physiol. 2019 09 02; 151(9):1116-1134. Sato D, Hernández-Hernández G, Matsumoto C, Tajada S, Moreno CM, Dixon RE, O'Dwyer S, Navedo MF, Trimmer JS, Clancy CE, Binder MD, Santana LF. PMID: 31371391; PMCID: PMC6719406.
      View in: PubMed   Mentions: 25     Fields:    
    41. Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia. J Clin Invest. 2019 06 04; 129(8):3140-3152. Syed AU, Reddy GR, Ghosh D, Prada MP, Nystoriak MA, Morotti S, Grandi E, Sirish P, Chiamvimonvat N, Hell JW, Santana LF, Xiang YK, Nieves-Cintrón M, Navedo MF. PMID: 31162142; PMCID: PMC6668679.
      View in: PubMed   Mentions: 30     Fields:    
    42. β-adrenergic-mediated dynamic augmentation of sarcolemmal CaV 1.2 clustering and co-operativity in ventricular myocytes. J Physiol. 2019 04; 597(8):2139-2162. Ito DW, Hannigan KI, Ghosh D, Xu B, Del Villar SG, Xiang YK, Dickson EJ, Navedo MF, Dixon RE. PMID: 30714156; PMCID: PMC6462464.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    43. A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia. Elife. 2019 03 01; 8. Prada MP, Syed AU, Buonarati OR, Reddy GR, Nystoriak MA, Ghosh D, Simó S, Sato D, Sasse KC, Ward SM, Santana LF, Xiang YK, Hell JW, Nieves-Cintrón M, Navedo MF. PMID: 30821687; PMCID: PMC6397001.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    44. Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins. Proc Natl Acad Sci U S A. 2018 12 04; 115(49):E11465-E11474. Smith FD, Omar MH, Nygren PJ, Soughayer J, Hoshi N, Lau HT, Snyder CG, Branon TC, Ghosh D, Langeberg LK, Ting AY, Santana LF, Ong SE, Navedo MF, Scott JD. PMID: 30455320; PMCID: PMC6298107.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    45. Dynamic L-type CaV1.2 channel trafficking facilitates CaV1.2 clustering and cooperative gating. Biochim Biophys Acta Mol Cell Res. 2018 09; 1865(9):1341-1355. Ghosh D, Nieves-Cintrón M, Tajada S, Brust-Mascher I, Horne MC, Hell JW, Dixon RE, Santana LF, Navedo MF. PMID: 29959960; PMCID: PMC6407617.
      View in: PubMed   Mentions: 18     Fields:    
    46. Corrigendum: Diabetic cornea wounds produce significantly weaker electric signals that may contribute to impaired healing. Sci Rep. 2018 Jun 27; 8:46997. Shen Y, Pfluger T, Ferreira F, Liang J, Navedo MF, Zeng Q, Reid B, Zhao M. PMID: 29947346; PMCID: PMC6020011.
      View in: PubMed   Mentions:    Fields:    
    47. Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell. Nat Commun. 2018 03 13; 9(1):1050. Shen A, Nieves-Cintron M, Deng Y, Shi Q, Chowdhury D, Qi J, Hell JW, Navedo MF, Xiang YK. PMID: 29535304; PMCID: PMC5849717.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    48. Going with the flow: contextual fine-tuning of vascular reactivity. J Physiol. 2018 04 01; 596(7):1127-1128. Navedo MF, Amberg GC. PMID: 29427447; PMCID: PMC5878216.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    49. A model for cooperative gating of L-type Ca2+ channels and its effects on cardiac alternans dynamics. PLoS Comput Biol. 2018 01; 14(1):e1005906. Sato D, Dixon RE, Santana LF, Navedo MF. PMID: 29338006; PMCID: PMC5786340.
      View in: PubMed   Mentions: 13     Fields:    
    50. Coronary microvascular Kv1 channels as regulatory sensors of intracellular pyridine nucleotide redox potential. Microcirculation. 2018 01; 25(1). Dwenger MM, Ohanyan V, Navedo MF, Nystoriak MA. PMID: 29110409; PMCID: PMC5760281.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    51. Regulation of voltage-gated potassium channels in vascular smooth muscle during hypertension and metabolic disorders. Microcirculation. 2018 01; 25(1). Nieves-Cintrón M, Syed AU, Nystoriak MA, Navedo MF. PMID: 29044853; PMCID: PMC5760350.
      View in: PubMed   Mentions: 29     Fields:    
    52. Regulation of microvascular function by voltage-gated potassium channels: New tricks for an "ancient" dog. Microcirculation. 2018 01; 25(1). Nystoriak MA, Navedo MF. PMID: 29239491; PMCID: PMC5826567.
      View in: PubMed   Mentions: 1     Fields:    
    53. Impaired BKCa channel function in native vascular smooth muscle from humans with type 2 diabetes. Sci Rep. 2017 10 25; 7(1):14058. Nieves-Cintrón M, Syed AU, Buonarati OR, Rigor RR, Nystoriak MA, Ghosh D, Sasse KC, Ward SM, Santana LF, Hell JW, Navedo MF. PMID: 29070899; PMCID: PMC5656614.
      View in: PubMed   Mentions: 23     Fields:    
    54. Distance constraints on activation of TRPV4 channels by AKAP150-bound PKCα in arterial myocytes. J Gen Physiol. 2017 Jun 05; 149(6):639-659. Tajada S, Moreno CM, O'Dwyer S, Woods S, Sato D, Navedo MF, Santana LF. PMID: 28507079; PMCID: PMC5460949.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    55. Predominant contribution of L-type Cav1.2 channel stimulation to impaired intracellular calcium and cerebral artery vasoconstriction in diabetic hyperglycemia. Channels (Austin). 2017 Jul 04; 11(4):340-346. Morotti S, Nieves-Cintrón M, Nystoriak MA, Navedo MF, Grandi E. PMID: 28631947; PMCID: PMC5555263.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    56. Science Signaling Podcast for 24 January 2017: Tissue-specific regulation of L-type calcium channels. Sci Signal. 2017 01 24; 10(463). Hell JW, Navedo MF, VanHook AM. PMID: 28119457; PMCID: PMC5312676.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    57. Phosphorylation of Ser1928 mediates the enhanced activity of the L-type Ca2+ channel Cav1.2 by the β2-adrenergic receptor in neurons. Sci Signal. 2017 01 24; 10(463). Qian H, Patriarchi T, Price JL, Matt L, Lee B, Nieves-Cintrón M, Buonarati OR, Chowdhury D, Nanou E, Nystoriak MA, Catterall WA, Poomvanicha M, Hofmann F, Navedo MF, Hell JW. PMID: 28119465; PMCID: PMC5310946.
      View in: PubMed   Mentions: 58     Fields:    
    58. Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes. Sci Signal. 2017 01 24; 10(463). Nystoriak MA, Nieves-Cintrón M, Patriarchi T, Buonarati OR, Prada MP, Morotti S, Grandi E, Fernandes JD, Forbush K, Hofmann F, Sasse KC, Scott JD, Ward SM, Hell JW, Navedo MF. PMID: 28119464; PMCID: PMC5297430.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    59. Potassium channels in the heart: structure, function and regulation. J Physiol. 2017 04 01; 595(7):2209-2228. Grandi E, Sanguinetti MC, Bartos DC, Bers DM, Chen-Izu Y, Chiamvimonvat N, Colecraft HM, Delisle BP, Heijman J, Navedo MF, Noskov S, Proenza C, Vandenberg JI, Yarov-Yarovoy V. PMID: 27861921; PMCID: PMC5374109.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimals
    60. Calcium Channels in Vascular Smooth Muscle. Adv Pharmacol. 2017; 78:49-87. Ghosh D, Syed AU, Prada MP, Nystoriak MA, Santana LF, Nieves-Cintrón M, Navedo MF. PMID: 28212803; PMCID: PMC5439506.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    61. Diabetic cornea wounds produce significantly weaker electric signals that may contribute to impaired healing. Sci Rep. 2016 06 10; 6:26525. Shen Y, Pfluger T, Ferreira F, Liang J, Navedo MF, Zeng Q, Reid B, Zhao M. PMID: 27283241; PMCID: PMC4901296.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    62. Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the β2 adrenergic receptor. EMBO J. 2016 06 15; 35(12):1330-45. Patriarchi T, Qian H, Di Biase V, Malik ZA, Chowdhury D, Price JL, Hammes EA, Buonarati OR, Westenbroek RE, Catterall WA, Hofmann F, Xiang YK, Murphy GG, Chen CY, Navedo MF, Hell JW. PMID: 27103070; PMCID: PMC4910527.
      View in: PubMed   Mentions: 37     Fields:    
    63. Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes. J Biol Chem. 2016 Mar 04; 291(10):4912. Nieves-Cintrón M, Nystoriak MA, Prada MP, Johnson K, Fayer W, Dell'Acqua ML, Scott JD, Navedo MF. PMID: 26945093; PMCID: PMC4777829.
      View in: PubMed   Mentions: 1     Fields:    
    64. AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K(+) currents in ventricular myocytes following myocardial infarction. Cell Signal. 2016 07; 28(7):733-40. Nieves-Cintrón M, Hirenallur-Shanthappa D, Nygren PJ, Hinke SA, Dell'Acqua ML, Langeberg LK, Navedo M, Santana LF, Scott JD. PMID: 26724383; PMCID: PMC4902329.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    65. Arterial Smooth Muscle Mitochondria Amplify Hydrogen Peroxide Microdomains Functionally Coupled to L-Type Calcium Channels. Circ Res. 2015 Dec 04; 117(12):1013-23. Chaplin NL, Nieves-Cintrón M, Fresquez AM, Navedo MF, Amberg GC. PMID: 26390880; PMCID: PMC4670591.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    66. Graded Ca²⁺/calmodulin-dependent coupling of voltage-gated CaV1.2 channels. Elife. 2015 Feb 25; 4. Dixon RE, Moreno CM, Yuan C, Opitz-Araya X, Binder MD, Navedo MF, Santana LF. PMID: 25714924; PMCID: PMC4360655.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    67. Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes. J Biol Chem. 2015 Mar 20; 290(12):7918-29. Nieves-Cintrón M, Nystoriak MA, Prada MP, Johnson K, Fayer W, Dell'Acqua ML, Scott JD, Navedo MF. PMID: 25670860; PMCID: PMC4367290.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    68. Mission CaMKIIγ: shuttle calmodulin from membrane to nucleus. Cell. 2014 Oct 09; 159(2):235-7. Malik ZA, Stein IS, Navedo MF, Hell JW. PMID: 25303520; PMCID: PMC7031110.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    69. AKAP5 keeps L-type channels and NFAT on their toes. Cell Rep. 2014 Jun 12; 7(5):1341-1342. Navedo MF, Hell JW. PMID: 24926793; PMCID: PMC7032163.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    70. Local control of TRPV4 channels by AKAP150-targeted PKC in arterial smooth muscle. J Gen Physiol. 2014 May; 143(5):559-75. Mercado J, Baylie R, Navedo MF, Yuan C, Scott JD, Nelson MT, Brayden JE, Santana LF. PMID: 24778429; PMCID: PMC4003184.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    71. AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus. Circ Res. 2014 Feb 14; 114(4):607-15. Nystoriak MA, Nieves-Cintrón M, Nygren PJ, Hinke SA, Nichols CB, Chen CY, Puglisi JL, Izu LT, Bers DM, Dell'acqua ML, Scott JD, Santana LF, Navedo MF. PMID: 24323672; PMCID: PMC3954117.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    72. Regulation of L-type calcium channel sparklet activity by c-Src and PKC-α. Am J Physiol Cell Physiol. 2013 Sep; 305(5):C568-77. Gulia J, Navedo MF, Gui P, Chao JT, Mercado JL, Santana LF, Davis MJ. PMID: 23804206; PMCID: PMC3761150.
      View in: PubMed   Mentions: 7     Fields:    
    73. Local regulation of L-type Ca²⁺ channel sparklets in arterial smooth muscle. Microcirculation. 2013 May; 20(4):290-8. Navedo MF, Amberg GC. PMID: 23116449; PMCID: PMC3577995.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    74. Calcium dynamics in vascular smooth muscle. Microcirculation. 2013 May; 20(4):281-9. Amberg GC, Navedo MF. PMID: 23384444; PMCID: PMC3651748.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    75. CaV1.2 sparklets in heart and vascular smooth muscle. J Mol Cell Cardiol. 2013 May; 58:67-76. Navedo MF, Santana LF. PMID: 23220157; PMCID: PMC3678956.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    76. Anchored phosphatases modulate glucose homeostasis. The EMBO Journal. 2012 Nov 28; 31(23):4481-4481. Hinke HS, Navedo NM, Ulman UA, Whiting WJ, Nygren NP, Tian TG, Jimenez-Caliani JA, Langeberg LL, Cirulli CV, Tengholm TA, Dell'Acqua DM, Santana SL, Scott SJ. .
      View in: Publisher Site   Mentions:
    77. Capturing single L-type Ca(2+) channel function with optics. Biochim Biophys Acta. 2013 Jul; 1833(7):1657-64. Nystoriak MA, Nieves-Cintrón M, Navedo MF. PMID: 23124113; PMCID: PMC3574202.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    78. Anchored phosphatases modulate glucose homeostasis. EMBO J. 2012 Oct 17; 31(20):3991-4004. Hinke SA, Navedo MF, Ulman A, Whiting JL, Nygren PJ, Tian G, Jimenez-Caliani AJ, Langeberg LK, Cirulli V, Tengholm A, Dell'Acqua ML, Santana LF, Scott JD. PMID: 22940692; PMCID: PMC3474922.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    79. Ca2+ signaling amplification by oligomerization of L-type Cav1.2 channels. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):1749-54. Dixon RE, Yuan C, Cheng EP, Navedo MF, Santana LF. PMID: 22307641; PMCID: PMC3277143.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    80. Relationship between Ca2+ sparklets and sarcoplasmic reticulum Ca2+ load and release in rat cerebral arterial smooth muscle. Am J Physiol Heart Circ Physiol. 2011 Dec; 301(6):H2285-94. Takeda Y, Nystoriak MA, Nieves-Cintrón M, Santana LF, Navedo MF. PMID: 21984539; PMCID: PMC3233819.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    81. Restoration of normal L-type Ca2+ channel function during Timothy syndrome by ablation of an anchoring protein. Circ Res. 2011 Jul 22; 109(3):255-61. Cheng EP, Yuan C, Navedo MF, Dixon RE, Nieves-Cintrón M, Scott JD, Santana LF. PMID: 21700933; PMCID: PMC3151468.
      View in: PubMed   Mentions: 66     Fields:    
    82. Natural inequalities: why some L-type Ca2+ channels work harder than others. J Gen Physiol. 2010 Aug; 136(2):143-7. Santana LF, Navedo MF. PMID: 20660657; PMCID: PMC2912067.
      View in: PubMed   Mentions: 5     Fields:    
    83. Sympathetic stimulation of adult cardiomyocytes requires association of AKAP5 with a subpopulation of L-type calcium channels. Circ Res. 2010 Sep 17; 107(6):747-56. Nichols CB, Rossow CF, Navedo MF, Westenbroek RE, Catterall WA, Santana LF, McKnight GS. PMID: 20671242; PMCID: PMC2981172.
      View in: PubMed   Mentions: 78     Fields:    
    84. Knockout of Na+/Ca2+ exchanger in smooth muscle attenuates vasoconstriction and L-type Ca2+ channel current and lowers blood pressure. Am J Physiol Heart Circ Physiol. 2010 May; 298(5):H1472-83. Zhang J, Ren C, Chen L, Navedo MF, Antos LK, Kinsey SP, Iwamoto T, Philipson KD, Kotlikoff MI, Santana LF, Wier WG, Matteson DR, Blaustein MP. PMID: 20173044; PMCID: PMC2867439.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    85. Increased coupled gating of L-type Ca2+ channels during hypertension and Timothy syndrome. Circ Res. 2010 Mar 05; 106(4):748-56. Navedo MF, Cheng EP, Yuan C, Votaw S, Molkentin JD, Scott JD, Santana LF. PMID: 20110531; PMCID: PMC2834417.
      View in: PubMed   Mentions: 86     Fields:    
    86. Elevated Ca2+ sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells. Am J Physiol Cell Physiol. 2010 Feb; 298(2):C211-20. Navedo MF, Takeda Y, Nieves-Cintrón M, Molkentin JD, Santana LF. PMID: 19846755; PMCID: PMC2822492.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    87. Molecular and biophysical mechanisms of Ca2+ sparklets in smooth muscle. J Mol Cell Cardiol. 2009 Oct; 47(4):436-44. Santana LF, Navedo MF. PMID: 19616004; PMCID: PMC2739251.
      View in: PubMed   Mentions: 22     Fields:    
    88. The control of Ca2+ influx and NFATc3 signaling in arterial smooth muscle during hypertension. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15623-8. Nieves-Cintrón M, Amberg GC, Navedo MF, Molkentin JD, Santana LF. PMID: 18832165; PMCID: PMC2557027.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    89. Functional contribution of alpha3L8' to the neuronal nicotinic alpha3 receptor. J Neurosci Res. 2008 Oct; 86(13):2884-94. Nieves-Cintrón M, Caballero-Rivera D, Silva WI, Navedo MF, Lasalde-Dominicci JA. PMID: 18615639; PMCID: PMC4586081.
      View in: PubMed   Mentions:    Fields:    
    90. Calcium sparklets in arterial smooth muscle. Clin Exp Pharmacol Physiol. 2008 Sep; 35(9):1121-6. Santana LF, Navedo MF, Amberg GC, Nieves-Cintrón M, Votaw VS, Ufret-Vincenty CA. PMID: 18215181; PMCID: PMC5832963.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    91. AKAP150 is required for stuttering persistent Ca2+ sparklets and angiotensin II-induced hypertension. Circ Res. 2008 Feb 01; 102(2):e1-e11. Navedo MF, Nieves-Cintrón M, Amberg GC, Yuan C, Votaw VS, Lederer WJ, McKnight GS, Santana LF. PMID: 18174462.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    92. Ca(v)1.3 channels produce persistent calcium sparklets, but Ca(v)1.2 channels are responsible for sparklets in mouse arterial smooth muscle. Am J Physiol Heart Circ Physiol. 2007 Sep; 293(3):H1359-70. Navedo MF, Amberg GC, Westenbroek RE, Sinnegger-Brauns MJ, Catterall WA, Striessnig J, Santana LF. PMID: 17526649.
      View in: PubMed   Mentions: 25     Fields:    
    93. Calcium sparklets regulate local and global calcium in murine arterial smooth muscle. J Physiol. 2007 Feb 15; 579(Pt 1):187-201. Amberg GC, Navedo MF, Nieves-Cintrón M, Molkentin JD, Santana LF. PMID: 17158168; PMCID: PMC2075382.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    94. Contribution of valine 7' of TMD2 to gating of neuronal alpha3 receptor subtypes. J Neurosci Res. 2006 Dec; 84(8):1778-88. Nieves-Cintrón M, Caballero-Rivera D, Navedo MF, Lasalde-Dominicci JA. PMID: 17044037.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    95. Mechanisms underlying heterogeneous Ca2+ sparklet activity in arterial smooth muscle. J Gen Physiol. 2006 Jun; 127(6):611-22. Navedo MF, Amberg GC, Nieves M, Molkentin JD, Santana LF. PMID: 16702354; PMCID: PMC2151539.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    96. Novel beta subunit mutation causes a slow-channel syndrome by enhancing activation and decreasing the rate of agonist dissociation. Mol Cell Neurosci. 2006 May-Jun; 32(1-2):82-90. Navedo MF, Lasalde-Dominicci JA, Báez-Pagán CA, Díaz-Pérez L, Rojas LV, Maselli RA, Staub J, Schott K, Zayas R, Gomez CM. PMID: 16624571; PMCID: PMC4636114.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    97. On the loose: uncaging Ca2+ -induced Ca2+ release in smooth muscle. J Gen Physiol. 2006 Mar; 127(3):221-3. Amberg GC, Navedo MF, Santana LF. PMID: 16505144; PMCID: PMC2151499.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    98. Constitutively active L-type Ca2+ channels. Proc Natl Acad Sci U S A. 2005 Aug 02; 102(31):11112-7. Navedo MF, Amberg GC, Votaw VS, Santana LF. PMID: 16040810; PMCID: PMC1180225.
      View in: PubMed   Mentions: 113     Fields:    Translation:AnimalsCells
    99. NFATc3 regulates Kv2.1 expression in arterial smooth muscle. J Biol Chem. 2004 Nov 05; 279(45):47326-34. Amberg GC, Rossow CF, Navedo MF, Santana LF. PMID: 15322114.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    100. Tryptophan substitutions reveal the role of nicotinic acetylcholine receptor alpha-TM3 domain in channel gating: differences between Torpedo and muscle-type AChR. Biochemistry. 2004 Jan 13; 43(1):78-84. Navedo M, Nieves M, Rojas L, Lasalde-Dominicci JA. PMID: 14705933.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    101. Novel delta subunit mutation in slow-channel syndrome causes severe weakness by novel mechanisms. Ann Neurol. 2002 Jan; 51(1):102-12. Gomez CM, Maselli RA, Vohra BP, Navedo M, Stiles JR, Charnet P, Schott K, Rojas L, Keesey J, Verity A, Wollmann RW, Lasalde-Dominicci J. PMID: 11782989; PMCID: PMC4841278.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
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