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Manuel F Navedo

TitleASSOC PROF-HCOMP
InstitutionUniversity of California Davis
DepartmentMED: PHARMACOLOGY
Address451 Health Sciences Drive
CA 95616
Phone530-752-6880
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    Collapse Research 
    Collapse Research Activities and Funding
    Coupling of Vascular Cav1.2 Channels In Health & Disease
    NIH/NHLBI R01HL121059Jul 1, 2015 - Apr 30, 2019
    Role: Principal Investigator
    Calcium Sparklers-Induced Vascular Dysfunction During Diabetes
    NIH/NHLBI R01HL098200Jul 19, 2010 - May 31, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ghosh D, Nieves-Cintrón M, Tajada S, Brust-Mascher I, Horne MC, Hell JW, Dixon RE, Santana LF, Navedo M. Dynamic L-type CaV1.2 channel trafficking facilitates CaV1.2 clustering and cooperative gating. Biochim Biophys Acta. 2018 Jun 27. PMID: 29959960.
      View in: PubMed
    2. Shen A, Nieves-Cintron M, Deng Y, Shi Q, Chowdhury D, Qi J, Hell JW, Navedo M, Xiang YK. Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell. Nat Commun. 2018 03 13; 9(1):1050. PMID: 29535304.
      View in: PubMed
    3. Navedo M, Amberg GC. Going with the flow: contextual fine-tuning of vascular reactivity. J Physiol. 2018 Apr 01; 596(7):1127-1128. PMID: 29427447.
      View in: PubMed
    4. Sato D, Dixon RE, Santana LF, Navedo M. A model for cooperative gating of L-type Ca2+ channels and its effects on cardiac alternans dynamics. PLoS Comput Biol. 2018 Jan; 14(1):e1005906. PMID: 29338006.
      View in: PubMed
    5. Dwenger MM, Ohanyan V, Navedo M, Nystoriak MA. Coronary microvascular Kv1 channels as regulatory sensors of intracellular pyridine nucleotide redox potential. Microcirculation. 2018 Jan; 25(1). PMID: 29110409.
      View in: PubMed
    6. Nystoriak MA, Navedo M. Regulation of microvascular function by voltage-gated potassium channels: New tricks for an "ancient" dog. Microcirculation. 2018 Jan; 25(1). PMID: 29239491.
      View in: PubMed
    7. Nieves-Cintrón M, Syed AU, Nystoriak MA, Navedo M. Regulation of voltage-gated potassium channels in vascular smooth muscle during hypertension and metabolic disorders. Microcirculation. 2018 Jan; 25(1). PMID: 29044853.
      View in: PubMed
    8. Nieves-Cintrón M, Syed AU, Buonarati OR, Rigor RR, Nystoriak MA, Ghosh D, Sasse KC, Ward SM, Santana LF, Hell JW, Navedo M. Impaired BKCa channel function in native vascular smooth muscle from humans with type 2 diabetes. Sci Rep. 2017 Oct 25; 7(1):14058. PMID: 29070899.
      View in: PubMed
    9. Tajada S, Moreno CM, O'Dwyer S, Woods S, Sato D, Navedo M, Santana LF. Distance constraints on activation of TRPV4 channels by AKAP150-bound PKCa in arterial myocytes. J Gen Physiol. 2017 Jun 05; 149(6):639-659. PMID: 28507079.
      View in: PubMed
    10. Morotti S, Nieves-Cintrón M, Nystoriak MA, Navedo M, Grandi E. Predominant contribution of L-type Cav1.2 channel stimulation to impaired intracellular calcium and cerebral artery vasoconstriction in diabetic hyperglycemia. Channels (Austin). 2017 Jul 04; 11(4):340-346. PMID: 28631947.
      View in: PubMed
    11. Hell JW, Navedo M, VanHook AM. Science Signaling Podcast for 24 January 2017: Tissue-specific regulation of L-type calcium channels. Sci Signal. 2017 Jan 24; 10(463). PMID: 28119457.
      View in: PubMed
    12. Qian H, Patriarchi T, Price JL, Matt L, Lee B, Nieves-Cintrón M, Buonarati OR, Chowdhury D, Nanou E, Nystoriak MA, Catterall WA, Poomvanicha M, Hofmann F, Navedo M, Hell JW. Phosphorylation of Ser1928 mediates the enhanced activity of the L-type Ca2+ channel Cav1.2 by the ß2-adrenergic receptor in neurons. Sci Signal. 2017 Jan 24; 10(463). PMID: 28119465.
      View in: PubMed
    13. Nystoriak MA, Nieves-Cintrón M, Patriarchi T, Buonarati OR, Prada MP, Morotti S, Grandi E, Fernandes JD, Forbush K, Hofmann F, Sasse KC, Scott JD, Ward SM, Hell JW, Navedo M. Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes. Sci Signal. 2017 Jan 24; 10(463). PMID: 28119464.
      View in: PubMed
    14. Grandi E, Sanguinetti MC, Bartos DC, Bers DM, Chen-Izu Y, Chiamvimonvat N, Colecraft HM, Delisle BP, Heijman J, Navedo M, Noskov S, Proenza C, Vandenberg JI, Yarov-Yarovoy V. Potassium channels in the heart: structure, function and regulation. J Physiol. 2017 Apr 01; 595(7):2209-2228. PMID: 27861921.
      View in: PubMed
    15. Shen Y, Pfluger T, Ferreira F, Liang J, Navedo M, Zeng Q, Reid B, Zhao M. Diabetic cornea wounds produce significantly weaker electric signals that may contribute to impaired healing. Sci Rep. 2016 06 10; 6:26525. PMID: 27283241.
      View in: PubMed
    16. Patriarchi T, Qian H, Di Biase V, Malik ZA, Chowdhury D, Price JL, Hammes EA, Buonarati OR, Westenbroek RE, Catterall WA, Hofmann F, Xiang YK, Murphy GG, Chen CY, Navedo M, Hell JW. Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the ß2 adrenergic receptor. EMBO J. 2016 06 15; 35(12):1330-45. PMID: 27103070.
      View in: PubMed
    17. Nieves-Cintrón M, Hirenallur-Shanthappa D, Nygren PJ, Hinke SA, Dell'Acqua ML, Langeberg LK, Navedo M, Santana LF, Scott JD. AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K(+) currents in ventricular myocytes following myocardial infarction. Cell Signal. 2016 07; 28(7):733-40. PMID: 26724383; PMCID: PMC4902329 [Available on 07/01/17].
    18. Chaplin NL, Nieves-Cintrón M, Fresquez AM, Navedo M, Amberg GC. Arterial Smooth Muscle Mitochondria Amplify Hydrogen Peroxide Microdomains Functionally Coupled to L-Type Calcium Channels. Circ Res. 2015 Dec 04; 117(12):1013-23. PMID: 26390880; PMCID: PMC4670591 [Available on 12/04/16].
    19. Dixon RE, Moreno CM, Yuan C, Opitz-Araya X, Binder MD, Navedo M, Santana LF. Graded Ca²?/calmodulin-dependent coupling of voltage-gated CaV1.2 channels. Elife. 2015 Feb 25; 4. PMID: 25714924; PMCID: PMC4360655.
    20. Nieves-Cintrón M, Nystoriak MA, Prada MP, Johnson K, Fayer W, Dell'Acqua ML, Scott JD, Navedo M. Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes. J Biol Chem. 2015 Mar 20; 290(12):7918-29. PMID: 25670860; PMCID: PMC4367290.
    21. Malik ZA, Stein IS, Navedo M, Hell JW. Mission CaMKII?: shuttle calmodulin from membrane to nucleus. Cell. 2014 Oct 09; 159(2):235-7. PMID: 25303520.
      View in: PubMed
    22. Navedo M, Hell JW. AKAP5 keeps L-type channels and NFAT on their toes. Cell Rep. 2014 Jun 12; 7(5):1341-1342. PMID: 24926793.
      View in: PubMed
    23. Mercado J, Baylie R, Navedo M, Yuan C, Scott JD, Nelson MT, Brayden JE, Santana LF. Local control of TRPV4 channels by AKAP150-targeted PKC in arterial smooth muscle. J Gen Physiol. 2014 May; 143(5):559-75. PMID: 24778429; PMCID: PMC4003184.
    24. Nystoriak MA, Nieves-Cintrón M, Nygren PJ, Hinke SA, Nichols CB, Chen CY, Puglisi JL, Izu LT, Bers DM, Dell'acqua ML, Scott JD, Santana LF, Navedo M. AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus. Circ Res. 2014 Feb 14; 114(4):607-15. PMID: 24323672; PMCID: PMC3954117.
    25. Gulia J, Navedo M, Gui P, Chao JT, Mercado JL, Santana LF, Davis MJ. Regulation of L-type calcium channel sparklet activity by c-Src and PKC-a. Am J Physiol Cell Physiol. 2013 Sep; 305(5):C568-77. PMID: 23804206; PMCID: PMC3761150.
    26. Navedo M, Amberg GC. Local regulation of L-type Ca²? channel sparklets in arterial smooth muscle. Microcirculation. 2013 May; 20(4):290-8. PMID: 23116449; PMCID: PMC3577995.
    27. Amberg GC, Navedo M. Calcium dynamics in vascular smooth muscle. Microcirculation. 2013 May; 20(4):281-9. PMID: 23384444; PMCID: PMC3651748.
    28. Navedo M, Santana LF. CaV1.2 sparklets in heart and vascular smooth muscle. J Mol Cell Cardiol. 2013 May; 58:67-76. PMID: 23220157; PMCID: PMC3678956.
    29. Nystoriak MA, Nieves-Cintrón M, Navedo M. Capturing single L-type Ca(2+) channel function with optics. Biochim Biophys Acta. 2013 Jul; 1833(7):1657-64. PMID: 23124113; PMCID: PMC3574202.
    30. Hinke SA, Navedo M, Ulman A, Whiting JL, Nygren PJ, Tian G, Jimenez-Caliani AJ, Langeberg LK, Cirulli V, Tengholm A, Dell'Acqua ML, Santana LF, Scott JD. Anchored phosphatases modulate glucose homeostasis. EMBO J. 2012 Oct 17; 31(20):3991-4004. PMID: 22940692; PMCID: PMC3474922.
    31. Dixon RE, Yuan C, Cheng EP, Navedo M, Santana LF. Ca2+ signaling amplification by oligomerization of L-type Cav1.2 channels. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):1749-54. PMID: 22307641; PMCID: PMC3277143.
    32. Takeda Y, Nystoriak MA, Nieves-Cintrón M, Santana LF, Navedo M. Relationship between Ca2+ sparklets and sarcoplasmic reticulum Ca2+ load and release in rat cerebral arterial smooth muscle. Am J Physiol Heart Circ Physiol. 2011 Dec; 301(6):H2285-94. PMID: 21984539; PMCID: PMC3233819.
    33. Cheng EP, Yuan C, Navedo M, Dixon RE, Nieves-Cintrón M, Scott JD, Santana LF. Restoration of normal L-type Ca2+ channel function during Timothy syndrome by ablation of an anchoring protein. Circ Res. 2011 Jul 22; 109(3):255-61. PMID: 21700933; PMCID: PMC3151468.
    34. Santana LF, Navedo M. Natural inequalities: why some L-type Ca2+ channels work harder than others. J Gen Physiol. 2010 Aug; 136(2):143-7. PMID: 20660657; PMCID: PMC2912067.
    35. Nichols CB, Rossow CF, Navedo M, Westenbroek RE, Catterall WA, Santana LF, McKnight GS. Sympathetic stimulation of adult cardiomyocytes requires association of AKAP5 with a subpopulation of L-type calcium channels. Circ Res. 2010 Sep 17; 107(6):747-56. PMID: 20671242; PMCID: PMC2981172.
    36. Zhang J, Ren C, Chen L, Navedo M, Antos LK, Kinsey SP, Iwamoto T, Philipson KD, Kotlikoff MI, Santana LF, Wier WG, Matteson DR, Blaustein MP. Knockout of Na+/Ca2+ exchanger in smooth muscle attenuates vasoconstriction and L-type Ca2+ channel current and lowers blood pressure. Am J Physiol Heart Circ Physiol. 2010 May; 298(5):H1472-83. PMID: 20173044; PMCID: PMC2867439.
    37. Navedo M, Cheng EP, Yuan C, Votaw S, Molkentin JD, Scott JD, Santana LF. Increased coupled gating of L-type Ca2+ channels during hypertension and Timothy syndrome. Circ Res. 2010 Mar 05; 106(4):748-56. PMID: 20110531; PMCID: PMC2834417.
    38. Navedo M, Takeda Y, Nieves-Cintrón M, Molkentin JD, Santana LF. Elevated Ca2+ sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells. Am J Physiol Cell Physiol. 2010 Feb; 298(2):C211-20. PMID: 19846755; PMCID: PMC2822492.
    39. Santana LF, Navedo M. Molecular and biophysical mechanisms of Ca2+ sparklets in smooth muscle. J Mol Cell Cardiol. 2009 Oct; 47(4):436-44. PMID: 19616004; PMCID: PMC2739251.
    40. Nieves-Cintrón M, Amberg GC, Navedo M, Molkentin JD, Santana LF. The control of Ca2+ influx and NFATc3 signaling in arterial smooth muscle during hypertension. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15623-8. PMID: 18832165; PMCID: PMC2557027.
    41. Santana LF, Navedo M, Amberg GC, Nieves-Cintrón M, Votaw VS, Ufret-Vincenty CA. Calcium sparklets in arterial smooth muscle. Clin Exp Pharmacol Physiol. 2008 Sep; 35(9):1121-6. PMID: 18215181.
      View in: PubMed
    42. Navedo M, Nieves-Cintrón M, Amberg GC, Yuan C, Votaw VS, Lederer WJ, McKnight GS, Santana LF. AKAP150 is required for stuttering persistent Ca2+ sparklets and angiotensin II-induced hypertension. Circ Res. 2008 Feb 01; 102(2):e1-e11. PMID: 18174462.
      View in: PubMed
    43. Navedo M, Amberg GC, Westenbroek RE, Sinnegger-Brauns MJ, Catterall WA, Striessnig J, Santana LF. Ca(v)1.3 channels produce persistent calcium sparklets, but Ca(v)1.2 channels are responsible for sparklets in mouse arterial smooth muscle. Am J Physiol Heart Circ Physiol. 2007 Sep; 293(3):H1359-70. PMID: 17526649.
      View in: PubMed
    44. Amberg GC, Navedo M, Nieves-Cintrón M, Molkentin JD, Santana LF. Calcium sparklets regulate local and global calcium in murine arterial smooth muscle. J Physiol. 2007 Feb 15; 579(Pt 1):187-201. PMID: 17158168; PMCID: PMC2075382.
    45. Navedo M, Amberg GC, Nieves M, Molkentin JD, Santana LF. Mechanisms underlying heterogeneous Ca2+ sparklet activity in arterial smooth muscle. J Gen Physiol. 2006 Jun; 127(6):611-22. PMID: 16702354; PMCID: PMC2151539.
    46. Amberg GC, Navedo M, Santana LF. On the loose: uncaging Ca2+ -induced Ca2+ release in smooth muscle. J Gen Physiol. 2006 Mar; 127(3):221-3. PMID: 16505144; PMCID: PMC2151499.
    47. Navedo M, Amberg GC, Votaw VS, Santana LF. Constitutively active L-type Ca2+ channels. Proc Natl Acad Sci U S A. 2005 Aug 02; 102(31):11112-7. PMID: 16040810; PMCID: PMC1180225.
    48. Amberg GC, Rossow CF, Navedo M, Santana LF. NFATc3 regulates Kv2.1 expression in arterial smooth muscle. J Biol Chem. 2004 Nov 05; 279(45):47326-34. PMID: 15322114.
      View in: PubMed