Chao-Yin Chen

Title(s)Professor, Pharmacology
SchoolSchool of Medicine
Address2217 Tupper
CA 95616
Phone530-754-6458
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    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms underlying secondhand smoke-induced cardiovascular dysfunction
    NIH R01ES025229May 1, 2015 - Jan 31, 2021
    Role: Principal Investigator
    Particulate Matter Exposure: Cardiovascular Mechanisms
    NIH R01ES012957May 1, 2004 - Mar 31, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Opportunities and barriers to translating the hibernation phenotype for neurocritical care. Front Neurol. 2023; 14:1009718. Drew KL, Bhowmick S, Laughlin BW, Goropashnaya AV, Tøien Ø, Sugiura MH, Wong A, Pourrezaei K, Barati Z, Chen CY. PMID: 36779060; PMCID: PMC9911456.
      View in: PubMed   Mentions:
    2. Editorial: Methods and applications in integrative physiology. Front Physiol. 2022; 13:1096216. Baltatu OC, Chen CY, Caluori G. PMID: 36531172; PMCID: PMC9748736.
      View in: PubMed   Mentions:
    3. Secondhand Smoke Decreased Excitability and Altered Action Potential Characteristics of Cardiac Vagal Neurons in Mice. Front Physiol. 2021; 12:727000. Sun J, Pan S, Karey E, Chen YJ, Pinkerton KE, Wilson CG, Chen CY. PMID: 34630146; PMCID: PMC8498211.
      View in: PubMed   Mentions: 3  
    4. Secondhand Smoke Exposure Impairs Ion Channel Function and Contractility of Mesenteric Arteries. Function (Oxf). 2021; 2(5):zqab041. Le T, Martín-Aragón Baudel M, Syed A, Singhrao N, Pan S, Flores-Tamez VA, Burns AE, Man KNM, Karey E, Hong J, Hell JW, Pinkerton KE, Chen CY, Nieves-Cintrón M. PMID: 34553140; PMCID: PMC8448673.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsPHPublic Health
    5. CRL5-dependent regulation of the small GTPases ARL4C and ARF6 controls hippocampal morphogenesis. Proc Natl Acad Sci U S A. 2020 09 15; 117(37):23073-23084. Han JS, Hino K, Li W, Reyes RV, Canales CP, Miltner AM, Haddadi Y, Sun J, Chen CY, La Torre A, Simó S. PMID: 32873638; PMCID: PMC7502717.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    6. Device profile of the MobiusHD EVBA system for the treatment of resistant hypertension: overview of its mechanism of action, safety and efficacy. Expert Rev Med Devices. 2020 Jul; 17(7):649-658. Bates MC, Stone GW, Chen CY, Spiering W. PMID: 32510250; PMCID: PMC7453969.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    7. Cardiopulmonary Health Effects of Airborne Particulate Matter: Correlating Animal Toxicology to Human Epidemiology. Toxicol Pathol. 2019 12; 47(8):954-961. Pinkerton KE, Chen CY, Mack SM, Upadhyay P, Wu CW, Yuan W. PMID: 31645209; PMCID: PMC6911013.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsPHPublic Health
    8. The Use of Percent Change in RR Interval for Data Exclusion in Analyzing 24-h Time Domain Heart Rate Variability in Rodents. Front Physiol. 2019; 10:693. Karey E, Pan S, Morris AN, Bruun DA, Lein PJ, Chen CY. PMID: 31244671; PMCID: PMC6562196.
      View in: PubMed   Mentions: 4  
    9. Exposure to Secondhand Smoke and Arrhythmogenic Cardiac Alternans in a Mouse Model. Environ Health Perspect. 2018 12; 126(12):127001. Wang Z, Wang L, Tapa S, Pinkerton KE, Chen CY, Ripplinger CM. PMID: 30675795; PMCID: PMC6371715.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsPHPublic Health
    10. Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model. Cell Rep. 2018 07 10; 24(2):355-365. Mizuno GO, Wang Y, Shi G, Wang Y, Sun J, Papadopoulos S, Broussard GJ, Unger EK, Deng W, Weick J, Bhattacharyya A, Chen CY, Yu G, Looger LL, Tian L. PMID: 29996097; PMCID: PMC6631348.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    11. Ca2+/calmodulin binding to PSD-95 mediates homeostatic synaptic scaling down. EMBO J. 2018 01 04; 37(1):122-138. Chowdhury D, Turner M, Patriarchi T, Hergarden AC, Anderson D, Zhang Y, Sun J, Chen CY, Ames JB, Hell JW. PMID: 29118000; PMCID: PMC5753037.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    12. Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2-null mice, a model of Rett syndrome. Neurobiol Dis. 2018 Jan; 109(Pt A):25-32. Chen CY, Di Lucente J, Lin YC, Lien CC, Rogawski MA, Maezawa I, Jin LW. PMID: 28927958; PMCID: PMC5696074.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    13. Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the β2 adrenergic receptor. EMBO J. 2016 06 15; 35(12):1330-45. Patriarchi T, Qian H, Di Biase V, Malik ZA, Chowdhury D, Price JL, Hammes EA, Buonarati OR, Westenbroek RE, Catterall WA, Hofmann F, Xiang YK, Murphy GG, Chen CY, Navedo MF, Hell JW. PMID: 27103070; PMCID: PMC4910527.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    14. Perampanel inhibition of AMPA receptor currents in cultured hippocampal neurons. PLoS One. 2014; 9(9):e108021. Chen CY, Matt L, Hell JW, Rogawski MA. PMID: 25229608; PMCID: PMC4168215.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    15. AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus. Circ Res. 2014 Feb 14; 114(4):607-15. Nystoriak MA, Nieves-Cintrón M, Nygren PJ, Hinke SA, Nichols CB, Chen CY, Puglisi JL, Izu LT, Bers DM, Dell'acqua ML, Scott JD, Santana LF, Navedo MF. PMID: 24323672; PMCID: PMC3954117.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    16. Protection of signal processing at low temperature in baroreceptive neurons in the nucleus tractus solitarius of Syrian hamsters, a hibernating species. Am J Physiol Regul Integr Comp Physiol. 2013 Nov 15; 305(10):R1153-62. Sekizawa S, Horwitz BA, Horowitz JM, Chen CY. PMID: 24068050; PMCID: PMC3841799.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    17. Temporal relationships of blood pressure, heart rate, baroreflex function, and body temperature change over a hibernation bout in Syrian hamsters. Am J Physiol Regul Integr Comp Physiol. 2013 Oct 01; 305(7):R759-68. Horwitz BA, Chau SM, Hamilton JS, Song C, Gorgone J, Saenz M, Horowitz JM, Chen CY. PMID: 23904107; PMCID: PMC3798792.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    18. Realignment of signal processing within a sensory brainstem nucleus as brain temperature declines in the Syrian hamster, a hibernating species. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2012 Apr; 198(4):267-82. Sekizawa S, Horowitz JM, Horwitz BA, Chen CY. PMID: 22262373; PMCID: PMC4016980.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    19. Retrograde release of endocannabinoids inhibits presynaptic GABA release to second-order baroreceptive neurons in NTS. Auton Neurosci. 2010 Dec 08; 158(1-2):44-50. Chen CY, Bonham AC, Dean C, Hopp FA, Hillard CJ, Seagard JL. PMID: 20580326; PMCID: PMC2976795.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    20. Postexercise hypotension: central mechanisms. Exerc Sport Sci Rev. 2010 Jul; 38(3):122-7. Chen CY, Bonham AC. PMID: 20577060; PMCID: PMC2936915.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimals
    21. Issues and challenges of non-tenure-track research faculty: the UC Davis School of Medicine experience. Acad Med. 2010 Jun; 85(6):1041-7. Howell LP, Chen CY, Joad JP, Green R, Callahan EJ, Bonham AC. PMID: 20505407.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Oxidative injury in the lungs of neonatal rats following short-term exposure to ultrafine iron and soot particles. J Toxicol Environ Health A. 2010; 73(12):837-47. Zhong CY, Zhou YM, Smith KR, Kennedy IM, Chen CY, Aust AE, Pinkerton KE. PMID: 20391124.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    23. Central neuroplasticity and decreased heart rate variability after particulate matter exposure in mice. Environ Health Perspect. 2009 Sep; 117(9):1448-53. Pham H, Bonham AC, Pinkerton KE, Chen CY. PMID: 19750112; PMCID: PMC2737024.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    24. Exercise reduces GABA synaptic input onto nucleus tractus solitarii baroreceptor second-order neurons via NK1 receptor internalization in spontaneously hypertensive rats. J Neurosci. 2009 Mar 04; 29(9):2754-61. Chen CY, Bechtold AG, Tabor J, Bonham AC. PMID: 19261870; PMCID: PMC2682348.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    25. Central mechanisms I: plasticity of central pathways. Handb Exp Pharmacol. 2009; (187):187-201. Chen CY, Joad JP, Bric J, Bonham AC. PMID: 18825341.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    26. Extended secondhand tobacco smoke exposure induces plasticity in nucleus tractus solitarius second-order lung afferent neurons in young guinea pigs. Eur J Neurosci. 2008 Aug; 28(4):771-81. Sekizawa S, Chen CY, Bechtold AG, Tabor JM, Bric JM, Pinkerton KE, Joad JP, Bonham AC. PMID: 18657181.
      View in: PubMed   Mentions: 19  Translation:HumansAnimalsCellsPHPublic Health
    27. Short-term secondhand smoke exposure decreases heart rate variability and increases arrhythmia susceptibility in mice. Am J Physiol Heart Circ Physiol. 2008 Aug; 295(2):H632-9. Chen CY, Chow D, Chiamvimonvat N, Glatter KA, Li N, He Y, Pinkerton KE, Bonham AC. PMID: 18552155; PMCID: PMC2519230.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsPHPublic Health
    28. Air pollutants and cough. Pulm Pharmacol Ther. 2007; 20(4):347-54. Joad JP, Sekizawa S, Chen CY, Bonham AC. PMID: 17174132.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsPHPublic Health
    29. Plasticity of brainstem mechanisms of cough. Respir Physiol Neurobiol. 2006 Jul 28; 152(3):312-9. Bonham AC, Sekizawa S, Chen CY, Joad JP. PMID: 16554189.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    30. Plasticity in the nucleus tractus solitarius and its influence on lung and airway reflexes. J Appl Physiol (1985). 2006 Jul; 101(1):322-7. Bonham AC, Chen CY, Sekizawa S, Joad JP. PMID: 16484366.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    31. Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases. Mol Pharmacol. 2005 Apr; 67(4):1369-81. Beeton C, Pennington MW, Wulff H, Singh S, Nugent D, Crossley G, Khaytin I, Calabresi PA, Chen CY, Gutman GA, Chandy KG. PMID: 15665253; PMCID: PMC4275123.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansAnimalsCells
    32. Glutamate suppresses GABA release via presynaptic metabotropic glutamate receptors at baroreceptor neurones in rats. J Physiol. 2005 Jan 15; 562(Pt 2):535-51. Chen CY, Bonham AC. PMID: 15539399; PMCID: PMC1665512.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    33. Passive smoke effects on cough and airways in young guinea pigs: role of brainstem substance P. Am J Respir Crit Care Med. 2004 Feb 15; 169(4):499-504. Joad JP, Munch PA, Bric JM, Evans SJ, Pinkerton KE, Chen CY, Bonham AC. PMID: 14644932.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCellsPHPublic Health
    34. Postexercise hypotension in conscious SHR is attenuated by blockade of substance P receptors in NTS. Am J Physiol Heart Circ Physiol. 2002 Nov; 283(5):H1856-62. Chen CY, Munch PA, Quail AW, Bonham AC. PMID: 12384463.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    35. Neuroplasticity in nucleus tractus solitarius neurons after episodic ozone exposure in infant primates. J Appl Physiol (1985). 2003 Feb; 94(2):819-27. Chen CY, Bonham AC, Plopper CG, Joad JP. PMID: 12433861.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    36. GABA(A) receptor activation at medullary sympathetic neurons contributes to postexercise hypotension. Am J Physiol Heart Circ Physiol. 2002 May; 282(5):H1615-24. Kajekar R, Chen CY, Mutoh T, Bonham AC. PMID: 11959623.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    37. Glutamatergic neural transmission in the nucleus tractus solitarius: N-methyl-D-aspartate receptors. Clin Exp Pharmacol Physiol. 2002 May-Jun; 29(5-6):497-502. Bonham AC, Chen CY. PMID: 12010198.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    38. Synaptic transmission in nucleus tractus solitarius is depressed by Group II and III but not Group I presynaptic metabotropic glutamate receptors in rats. J Physiol. 2002 Feb 01; 538(Pt 3):773-86. Chen CY, Ling Eh EH, Horowitz JM, Bonham AC. PMID: 11826164; PMCID: PMC2290096.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    39. Extended allergen exposure in asthmatic monkeys induces neuroplasticity in nucleus tractus solitarius. J Allergy Clin Immunol. 2001 Oct; 108(4):557-62. Chen CY, Bonham AC, Schelegle ES, Gershwin LJ, Plopper CG, Joad JP. PMID: 11590381.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsPHPublic Health
    40. Lung C-fiber CNS reflex: role in the respiratory consequences of extended environmental tobacco smoke exposure in young guinea pigs. Environ Health Perspect. 2001 Aug; 109 Suppl 4:573-8. Bonham AC, Chen CY, Mutoh T, Joad JP. PMID: 11544166; PMCID: PMC1240584.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCellsPHPublic Health
    41. Frequency limits on aortic baroreceptor input to nucleus tractus solitarii. Am J Physiol Heart Circ Physiol. 2000 Feb; 278(2):H577-85. Liu Z, Chen CY, Bonham AC. PMID: 10666090.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    42. Construction of a model demonstrating cardiovascular principles. Am J Physiol. 1999 Dec; 277(6 Pt 2):S67-83. Rodenbaugh DW, Collins HL, Chen CY, DiCarlo SE. PMID: 10644263.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    43. A presynaptic mechanism contributes to depression of autonomic signal transmission in NTS. Am J Physiol. 1999 10; 277(4):H1350-60. Chen CY, Horowitz JM, Bonham AC. PMID: 10516169.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    44. Metabotropic glutamate receptors depress vagal and aortic baroreceptor signal transmission in the NTS. Am J Physiol. 1998 11; 275(5):H1682-94. Liu Z, Chen CY, Bonham AC. PMID: 9815076.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    45. Non-NMDA and NMDA receptors transmit area postrema input to aortic baroreceptor neurons in NTS. Am J Physiol. 1998 11; 275(5):H1695-706. Chen CY, Bonham AC. PMID: 9815077.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    46. Daily exercise and gender influence arterial baroreflex regulation of heart rate and nerve activity. Am J Physiol. 1996 Nov; 271(5 Pt 2):H1840-8. Chen CY, DiCarlo SE. PMID: 8945899.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    47. Onset of exercise increases lumbar sympathetic nerve activity in rats. Med Sci Sports Exerc. 1996 Jun; 28(6):677-84. DiCarlo SE, Chen CY, Collins HL. PMID: 8784755.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    48. Enhanced cardiopulmonary reflex inhibition of heart rate during exercise. Med Sci Sports Exerc. 1995 Oct; 27(10):1399-405. Chen CY, DiCarlo SE, Collins HL. PMID: 8531611.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    49. Local modulation of adrenergic responses in the hindlimb vasculature of the intact conscious rat. J Physiol. 1995 Jun 15; 485 ( Pt 3):817-25. DiCarlo SE, Patil RD, Collins HL, Chen CY. PMID: 7562619; PMCID: PMC1158046.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    50. Daily spontaneous running alters behavioral and neurochemical indexes of nigrostriatal function. J Appl Physiol (1985). 1995 Apr; 78(4):1219-24. Dluzen DE, Liu B, Chen CY, DiCarlo SE. PMID: 7615427.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    51. Daily spontaneous running attenuated the central gain of the arterial baroreflex. Am J Physiol. 1995 Feb; 268(2 Pt 2):H662-9. Chen CY, DiCarlo SE, Scislo TJ. PMID: 7864192.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    52. Vagal afferents reflexly inhibit exercise in conscious rats. Med Sci Sports Exerc. 1994 Apr; 26(4):459-62. DiCarlo SE, Collins HL, Chen CY. PMID: 8201902.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
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