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Izumi Maezawa

TitleASSOC ADJ PROF-HCOMP
InstitutionUniversity of California Davis
DepartmentPathology and Laboratory Medicine
AddressM.I.N.D. Institute/UCDMC
CA 95817
Phone916-703-0392
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hilt S, Altman R, Kálai T, Maezawa I, Gong Q, Wachsmann-Hogiu S, Jin LW, Voss JC. A Bifunctional Anti-Amyloid Blocks Oxidative Stress and the Accumulation of Intraneuronal Amyloid-Beta. Molecules. 2018 Aug 12; 23(8). PMID: 30103547.
      View in: PubMed
    2. Di Lucente J, Nguyen HM, Wulff H, Jin LW, Maezawa I. The voltage-gated potassium channel Kv1.3 is required for microglial pro-inflammatory activation in vivo. Glia. 2018 Jul 25. PMID: 30043400.
      View in: PubMed
    3. Maezawa I, Nguyen HM, Di Lucente J, Jenkins DP, Singh V, Hilt S, Kim K, Rangaraju S, Levey AI, Wulff H, Jin LW. Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer's disease: preclinical proof of concept. Brain. 2018 Feb 01; 141(2):596-612. PMID: 29272333.
      View in: PubMed
    4. Jena PK, Sheng L, Di Lucente J, Jin LW, Maezawa I, Wan YY. Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet-induced systemic inflammation, microglial activation, and reduced neuroplasticity. FASEB J. 2018 May; 32(5):2866-2877. PMID: 29401580.
      View in: PubMed
    5. Chen YJ, Nguyen HM, Maezawa I, Jin LW, Wulff H. Inhibition of the potassium channel Kv1.3 reduces infarction and inflammation in ischemic stroke. Ann Clin Transl Neurol. 2018 Feb; 5(2):147-161. PMID: 29468176.
      View in: PubMed
    6. Chen CY, Di Lucente J, Lin YC, Lien CC, Rogawski MA, Maezawa I, Jin LW. Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2-null mice, a model of Rett syndrome. Neurobiol Dis. 2018 Jan; 109(Pt A):25-32. PMID: 28927958.
      View in: PubMed
    7. Maezawa I, Zou B, Di Lucente J, Cao WS, Pascual C, Weerasekara S, Zhang M, Xie XS, Hua DH, Jin LW. The Anti-Amyloid-ß and Neuroprotective Properties of a Novel Tricyclic Pyrone Molecule. J Alzheimers Dis. 2017; 58(2):559-574. PMID: 28482635.
      View in: PubMed
    8. Hilt S, Tang T, Walton JH, Budamagunta M, Maezawa I, Kálai T, Hideg K, Singh V, Wulff H, Gong Q, Jin LW, Louie A, Voss JC. A Metal-Free Method for Producing MRI Contrast at Amyloid-ß. J Alzheimers Dis. 2017; 55(4):1667-1681. PMID: 27911291.
      View in: PubMed
    9. Nguyen HM, Grössinger EM, Horiuchi M, Davis KW, Jin LW, Maezawa I, Wulff H. Differential Kv1.3, KCa3.1, and Kir2.1 expression in "classically" and "alternatively" activated microglia. Glia. 2017 01; 65(1):106-121. PMID: 27696527.
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    10. Horiuchi M, Smith L, Maezawa I, Jin LW. CX3CR1 ablation ameliorates motor and respiratory dysfunctions and improves survival of a Rett syndrome mouse model. Brain Behav Immun. 2017 Feb; 60:106-116. PMID: 26883520.
      View in: PubMed
    11. Chen YJ, Nguyen HM, Maezawa I, Grössinger EM, Garing AL, Köhler R, Jin LW, Wulff H. The potassium channel KCa3.1 constitutes a pharmacological target for neuroinflammation associated with ischemia/reperfusion stroke. J Cereb Blood Flow Metab. 2016 Dec; 36(12):2146-2161. PMID: 26661208.
      View in: PubMed
    12. Altman R, Ly S, Hilt S, Petrlova J, Maezawa I, Kálai T, Hideg K, Jin LW, Laurence TA, Voss JC. Protective spin-labeled fluorenes maintain amyloid beta peptide in small oligomers and limit transitions in secondary structure. Biochim Biophys Acta. 2015 Dec; 1854(12):1860-1870. PMID: 26374940.
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    13. Zhang L, Zhang S, Maezawa I, Trushin S, Minhas P, Pinto M, Jin LW, Prasain K, Nguyen TD, Yamazaki Y, Kanekiyo T, Bu G, Gateno B, Chang KO, Nath KA, Nemutlu E, Dzeja P, Pang YP, Hua DH, Trushina E. Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's Disease. EBioMedicine. 2015 Apr 01; 2(4):294-305. PMID: 26086035.
      View in: PubMed
    14. Jin LW, Horiuchi M, Wulff H, Liu XB, Cortopassi GA, Erickson JD, Maezawa I. Dysregulation of glutamine transporter SNAT1 in Rett syndrome microglia: a mechanism for mitochondrial dysfunction and neurotoxicity. J Neurosci. 2015 Feb 11; 35(6):2516-29. PMID: 25673846; PMCID: PMC4323531.
    15. Hong HS, Maezawa I, Petrlova J, Zhao XY, C Voss J, Jin LW. Tomoregulin (TMEFF2) Binds Alzheimer's Disease Amyloid-ß (Aß) Oligomer and AßPP and Protects Neurons from Aß-Induced Toxicity. J Alzheimers Dis. 2015; 48(3):731-43. PMID: 26402097.
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    16. Prior AM, Gunaratna MJ, Kikuchi D, Desper J, Kim Y, Chang KO, Maezawa I, Jin LW, Hua DH. Syntheses of 3-[(Alkylamino)methylene]-6-methylpyridine-2,4(1H,3H)-diones, 3-Substituted 7-Methyl-2H-pyrano[3,2-c]pyridine-2,5(6H)-dione Fluorescence Probes, and Tetrahydro-1H,9H-2,10-dioxa-9-azaanthracen-1-ones. Synthesis (Stuttg). 2014 Aug; 46(16):2179-2190. PMID: 25177061.
      View in: PubMed
    17. Lu J, Maezawa I, Weerasekara S, Erenler R, Nguyen TD, Nguyen J, Swisher LZ, Li J, Jin LW, Ranjan A, Srivastava SK, Hua DH. Syntheses, neural protective activities, and inhibition of glycogen synthase kinase-3ß of substituted quinolines. Bioorg Med Chem Lett. 2014 Aug 01; 24(15):3392-7. PMID: 24951331; PMCID: PMC4110911.
    18. Kálai T, Altman R, Maezawa I, Balog M, Morisseau C, Petrlova J, Hammock BD, Jin LW, Trudell JR, Voss JC, Hideg K. Synthesis and functional survey of new Tacrine analogs modified with nitroxides or their precursors. Eur J Med Chem. 2014 Apr 22; 77:343-50. PMID: 24657571; PMCID: PMC4065883.
    19. Yasui DH, Xu H, Dunaway KW, Lasalle JM, Jin LW, Maezawa I. MeCP2 modulates gene expression pathways in astrocytes. Mol Autism. 2013 Jan 25; 4(1):3. PMID: 23351786; PMCID: PMC3561260.
    20. Pokhrel L, Maezawa I, Nguyen TD, Chang KO, Jin LW, Hua DH. Inhibition of Acyl-CoA: cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloid ß (Aß) oligomers-induced neuronal cell death by tricyclic pyrone molecules. J Med Chem. 2012 Oct 25; 55(20):8969-73. PMID: 23025824; PMCID: PMC3486708.
    21. Maezawa I, Jenkins DP, Jin BE, Wulff H. Microglial KCa3.1 Channels as a Potential Therapeutic Target for Alzheimer's Disease. Int J Alzheimers Dis. 2012; 2012:868972. PMID: 22675649; PMCID: PMC3364551.
    22. Maezawa I, Calafiore M, Wulff H, Jin LW. Does microglial dysfunction play a role in autism and Rett syndrome? Neuron Glia Biol. 2011 Feb; 7(1):85-97. PMID: 22717189; PMCID: PMC4976478.
    23. Petrlova J, Kálai T, Maezawa I, Altman R, Harishchandra G, Hong HS, Bricarello DA, Parikh AN, Lorigan GA, Jin LW, Hideg K, Voss JC. The influence of spin-labeled fluorene compounds on the assembly and toxicity of the aß peptide. PLoS One. 2012; 7(4):e35443. PMID: 22558151; PMCID: PMC3340382.
    24. Greco CM, Navarro CS, Hunsaker MR, Maezawa I, Shuler JF, Tassone F, Delany M, Au JW, Berman RF, Jin LW, Schumann C, Hagerman PJ, Hagerman RJ. Neuropathologic features in the hippocampus and cerebellum of three older men with fragile X syndrome. Mol Autism. 2011 Feb 08; 2(1):2. PMID: 21303513; PMCID: PMC3045897.
    25. Maezawa I, Zimin PI, Wulff H, Jin LW. Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity. J Biol Chem. 2011 Feb 04; 286(5):3693-706. PMID: 20971854; PMCID: PMC3030372.
    26. Horiuchi M, Maezawa I, Itoh A, Wakayama K, Jin LW, Itoh T, Decarli C. Amyloid ß1-42 oligomer inhibits myelin sheet formation in vitro. Neurobiol Aging. 2012 Mar; 33(3):499-509. PMID: 20594620; PMCID: PMC3013291.
    27. Maezawa I, Jin LW. Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate. J Neurosci. 2010 Apr 14; 30(15):5346-56. PMID: 20392956.
      View in: PubMed
    28. Maezawa I, Swanberg S, Harvey D, LaSalle JM, Jin LW. Rett syndrome astrocytes are abnormal and spread MeCP2 deficiency through gap junctions. J Neurosci. 2009 Apr 22; 29(16):5051-61. PMID: 19386901; PMCID: PMC3436907.
    29. Hong HS, Maezawa I, Budamagunta M, Rana S, Shi A, Vassar R, Liu R, Lam KS, Cheng RH, Hua DH, Voss JC, Jin LW. Candidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agents. Neurobiol Aging. 2010 Oct; 31(10):1690-9. PMID: 19022536; PMCID: PMC2888733.
    30. Maezawa I, Hong HS, Liu R, Wu CY, Cheng RH, Kung MP, Kung HF, Lam KS, Oddo S, Laferla FM, Jin LW. Congo red and thioflavin-T analogs detect Abeta oligomers. J Neurochem. 2008 Jan; 104(2):457-68. PMID: 17953662.
      View in: PubMed
    31. Hong HS, Maezawa I, Yao N, Xu B, Diaz-Avalos R, Rana S, Hua DH, Cheng RH, Lam KS, Jin LW. Combining the rapid MTT formazan exocytosis assay and the MC65 protection assay led to the discovery of carbazole analogs as small molecule inhibitors of Abeta oligomer-induced cytotoxicity. Brain Res. 2007 Jan 26; 1130(1):223-34. PMID: 17157826; PMCID: PMC1880896.
    32. Ramos EM, Lin MT, Larson EB, Maezawa I, Tseng LH, Edwards KL, Schellenberg GD, Hansen JA, Kukull WA, Jin LW. Tumor necrosis factor alpha and interleukin 10 promoter region polymorphisms and risk of late-onset Alzheimer disease. Arch Neurol. 2006 Aug; 63(8):1165-9. PMID: 16908746.
      View in: PubMed
    33. Maezawa I, Hong HS, Wu HC, Battina SK, Rana S, Iwamoto T, Radke GA, Pettersson E, Martin GM, Hua DH, Jin LW. A novel tricyclic pyrone compound ameliorates cell death associated with intracellular amyloid-beta oligomeric complexes. J Neurochem. 2006 Jul; 98(1):57-67. PMID: 16805796.
      View in: PubMed
    34. Kaminksy W, Jin LW, Powell S, Maezawa I, Claborn K, Branham C, Kahr B. Polarimetric imaging of amyloid. Micron. 2006; 37(4):324-38. PMID: 16406217.
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    35. Maezawa I, Jin LW, Woltjer RL, Maeda N, Martin GM, Montine TJ, Montine KS. Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carboxy terminal fragment-associated cytotoxicity. J Neurochem. 2004 Dec; 91(6):1312-21. PMID: 15584908.
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    36. Jin LW, Shie FS, Maezawa I, Vincent I, Bird T. Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities. Am J Pathol. 2004 Mar; 164(3):975-85. PMID: 14982851; PMCID: PMC1614713.
    37. Jin LW, Claborn KA, Kurimoto M, Geday MA, Maezawa I, Sohraby F, Estrada M, Kaminksy W, Kahr B. Imaging linear birefringence and dichroism in cerebral amyloid pathologies. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15294-8. PMID: 14668440; PMCID: PMC307560.
    38. Maezawa I, Wang B, Hu Q, Martin GM, Jin LW, Oshima J. Alterations of chaperone protein expression in presenilin mutant neurons in response to glutamate excitotoxicity. Pathol Int. 2002 Sep; 52(9):551-4. PMID: 12406183.
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    39. Jin LW, Hua DH, Shie FS, Maezawa I, Sopher B, Martin GM. Novel tricyclic pyrone compounds prevent intracellular APP C99-induced cell death. J Mol Neurosci. 2002 Aug-Oct; 19(1-2):57-61. PMID: 12212794.
      View in: PubMed