Izumi Maezawa

Title(s)Associate Adjunct Professor, Pathology and Laboratory Medicine
SchoolSchool of Medicine
AddressM.I.N.D. Institute/UCDMC
CA 95817
Phone916-703-0392
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    Collapse Research 
    Collapse Research Activities and Funding
    Soluble epoxide hydrolase-regulated lipid signaling in Alzheimer?s disease
    NIH RF1AG071665Apr 1, 2021 - Mar 31, 2024
    Role: Principal Investigator
    Mitochondrial ROS and Microglia in Rett Syndrome
    NIH R01HD088832Aug 10, 2017 - May 31, 2022
    Role: Co-Principal Investigator
    The Role of KCa3.1 in Neuroinflammation in Alzheimer Disease
    NIH R01AG043788Sep 30, 2013 - May 31, 2019
    Role: Principal Investigator
    Glutamine Transporters SNAT1 and SNAT2 in Rett Syndrome Microglia
    NIH R21HD073631Jul 5, 2012 - Jun 30, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Effects of Sex and Western Diet on Spatial Lipidomic Profiles for the Hippocampus, Cortex, and Corpus Callosum in Mice Using MALDI MSI. J Am Soc Mass Spectrom. 2024 Mar 08. Shafer CC, Di Lucente J, Mendiola UR, Maezawa I, Jin LW, Neumann EK. PMID: 38456419.
      View in: PubMed   Mentions:    Fields:    
    2. Ketogenic diet and BHB rescue the fall of long-term potentiation in an Alzheimer's mouse model and stimulates synaptic plasticity pathway enzymes. Commun Biol. 2024 Feb 16; 7(1):195. Di Lucente J, Persico G, Zhou Z, Jin LW, Ramsey JJ, Rutkowsky JM, Montgomery CM, Tomilov A, Kim K, Giorgio M, Maezawa I, Cortopassi GA. PMID: 38366025; PMCID: PMC10873348.
      View in: PubMed   Mentions: Translation:HumansAnimals
    3. The ketone body β-hydroxybutyrate shifts microglial metabolism and suppresses amyloid-β oligomer-induced inflammation in human microglia. FASEB J. 2023 11; 37(11):e23261. Jin LW, Di Lucente J, Ruiz Mendiola U, Suthprasertporn N, Tomilov A, Cortopassi G, Kim K, Ramsey JJ, Maezawa I. PMID: 37878335.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    4. Cholesterol, Amyloid Beta, Fructose, and LPS Influence ROS and ATP Concentrations and the Phagocytic Capacity of HMC3 Human Microglia Cell Line. Int J Mol Sci. 2023 Jun 20; 24(12). Muñoz Herrera OM, Hong BV, Ruiz Mendiola U, Maezawa I, Jin LW, Lebrilla CB, Harvey DJ, Zivkovic AM. PMID: 37373543; PMCID: PMC10299308.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Transcriptomic and glycomic analyses highlight pathway-specific glycosylation alterations unique to Alzheimer's disease. Sci Rep. 2023 05 15; 13(1):7816. Tang X, Tena J, Di Lucente J, Maezawa I, Harvey DJ, Jin LW, Lebrilla CB, Zivkovic AM. PMID: 37188790; PMCID: PMC10185676.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    6. The role of FUT8-catalyzed core fucosylation in Alzheimer's amyloid-β oligomer-induced activation of human microglia. Glia. 2023 05; 71(5):1346-1359. Jin LW, di Lucente J, Ruiz Mendiola U, Tang X, Zivkovic AM, Lebrilla CB, Maezawa I. PMID: 36692036.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    7. Regio-Specific N-Glycome and N-Glycoproteome Map of the Elderly Human Brain With and Without Alzheimer's Disease. Mol Cell Proteomics. 2022 Nov; 21(11):100427. Tena J, Maezawa I, Barboza M, Wong M, Zhu C, Alvarez MR, Jin LW, Zivkovic AM, Lebrilla CB. PMID: 36252735; PMCID: PMC9674923.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    8. Plasma biomarkers predict cognitive trajectories in an ethnoracially and clinically diverse cohort: Mediation with hippocampal volume. Alzheimers Dement (Amst). 2022; 14(1):e12349. Sapkota S, Erickson K, Harvey D, Tomaszewski-Farias SE, Olichney JM, Johnson DK, Dugger BN, Mungas DM, Fletcher E, Maillard P, Seshadri S, Satizabal CL, Kautz T, Parent D, Tracy RP, Maezawa I, Jin LW, DeCarli C. PMID: 36092690; PMCID: PMC9434579.
      View in: PubMed   Mentions: 4  
    9. High-Density Lipoprotein Changes in Alzheimer's Disease Are APOE Genotype-Specific. Biomedicines. 2022 Jun 24; 10(7). Hong BV, Zheng J, Agus JK, Tang X, Lebrilla CB, Jin LW, Maezawa I, Erickson K, Harvey DJ, DeCarli CS, Mungas DM, Olichney JM, Farias ST, Zivkovic AM. PMID: 35884800; PMCID: PMC9312991.
      View in: PubMed   Mentions: 5  
    10. Novel Stilbene-Nitroxyl Hybrid Compounds Display Discrete Modulation of Amyloid Beta Toxicity and Structure. Front Chem. 2022; 10:896386. Hilt S, Liu R, Maezawa I, Rojalin T, Aung HH, Budamagunta M, Slez R, Gong Q, Carney RP, Voss JC. PMID: 35720993; PMCID: PMC9204515.
      View in: PubMed   Mentions: 1  
    11. Glycosylation alterations in serum of Alzheimer's disease patients show widespread changes in N-glycosylation of proteins related to immune function, inflammation, and lipoprotein metabolism. Alzheimers Dement (Amst). 2022; 14(1):e12309. Tena J, Tang X, Zhou Q, Harvey D, Barajas-Mendoza M, Jin LW, Maezawa I, Zivkovic AM, Lebrilla CB. PMID: 35496372; PMCID: PMC9043904.
      View in: PubMed   Mentions: 5  
    12. 1700 nm optical coherence microscopy enables minimally invasive, label-free, in vivo optical biopsy deep in the mouse brain. Light Sci Appl. 2021 Jul 14; 10(1):145. Zhu J, Freitas HR, Maezawa I, Jin LW, Srinivasan VJ. PMID: 34262015; PMCID: PMC8280201.
      View in: PubMed   Mentions: 11  
    13. Dysregulated bile acid receptor-mediated signaling and IL-17A induction are implicated in diet-associated hepatic health and cognitive function. Biomark Res. 2020 Nov 06; 8(1):59. Jena PK, Sheng L, Nguyen M, Di Lucente J, Hu Y, Li Y, Maezawa I, Jin LW, Wan YY. PMID: 33292701; PMCID: PMC7648397.
      View in: PubMed   Mentions: 16  
    14. Metabolic flux analysis of the neural cell glycocalyx reveals differential utilization of monosaccharides. Glycobiology. 2020 10 21; 30(11):859-871. Wong M, Xu G, Barboza M, Maezawa I, Jin LW, Zivkovic A, Lebrilla CB. PMID: 32337579; PMCID: PMC7581652.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    15. Biophysical basis for Kv1.3 regulation of membrane potential changes induced by P2X4-mediated calcium entry in microglia. Glia. 2020 11; 68(11):2377-2394. Nguyen HM, di Lucente J, Chen YJ, Cui Y, Ibrahim RH, Pennington MW, Jin LW, Maezawa I, Wulff H. PMID: 32525239; PMCID: PMC7540709.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    16. Intellectual and Developmental Disabilities Research Centers: A Multidisciplinary Approach to Understand the Pathogenesis of Methyl-CpG Binding Protein 2-related Disorders. Neuroscience. 2020 10 01; 445:190-206. Fagiolini M, Patrizi A, LeBlanc J, Jin LW, Maezawa I, Sinnett S, Gray SJ, Molholm S, Foxe JJ, Johnston MV, Naidu S, Blue M, Hossain A, Kadam S, Zhao X, Chang Q, Zhou Z, Zoghbi H. PMID: 32360592; PMCID: PMC8025698.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    17. Corrigendum to "Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's disease" [EBioMedicine 2 (2015) 294-305]. EBioMedicine. 2019 04; 42:532. Zhang L, Zhang S, Maezawa I, Trushin S, Minhas P, Pinto M, Jin LW, Prasain K, Nguyen TDT, Yamazaki Y, Kanekiyo T, Bu G, Gateno B, Chang KO, Nath KA, Nemutlu E, Dzeja P, Pang YP, Hua DH, Trushina E. PMID: 30956174; PMCID: PMC6491797.
      View in: PubMed   Mentions: 6     Fields:    
    18. Repurposing the KCa3.1 inhibitor senicapoc for Alzheimer's disease. Ann Clin Transl Neurol. 2019 Apr; 6(4):723-738. Jin LW, Lucente JD, Nguyen HM, Singh V, Singh L, Chavez M, Bushong T, Wulff H, Maezawa I. PMID: 31019997; PMCID: PMC6469250.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    19. A Bifunctional Anti-Amyloid Blocks Oxidative Stress and the Accumulation of Intraneuronal Amyloid-Beta. Molecules. 2018 Aug 12; 23(8). Hilt S, Altman R, Kálai T, Maezawa I, Gong Q, Wachsmann-Hogiu S, Jin LW, Voss JC. PMID: 30103547; PMCID: PMC6222334.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    20. The voltage-gated potassium channel Kv1.3 is required for microglial pro-inflammatory activation in vivo. Glia. 2018 09; 66(9):1881-1895. Di Lucente J, Nguyen HM, Wulff H, Jin LW, Maezawa I. PMID: 30043400; PMCID: PMC6185766.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    21. Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer's disease: preclinical proof of concept. Brain. 2018 02 01; 141(2):596-612. Maezawa I, Nguyen HM, Di Lucente J, Jenkins DP, Singh V, Hilt S, Kim K, Rangaraju S, Levey AI, Wulff H, Jin LW. PMID: 29272333; PMCID: PMC5837198.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    22. Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet-induced systemic inflammation, microglial activation, and reduced neuroplasticity. FASEB J. 2018 05; 32(5):2866-2877. Jena PK, Sheng L, Di Lucente J, Jin LW, Maezawa I, Wan YY. PMID: 29401580; PMCID: PMC5901391.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    23. Inhibition of the potassium channel Kv1.3 reduces infarction and inflammation in ischemic stroke. Ann Clin Transl Neurol. 2018 02; 5(2):147-161. Chen YJ, Nguyen HM, Maezawa I, Jin LW, Wulff H. PMID: 29468176; PMCID: PMC5817832.
      View in: PubMed   Mentions: 24     Fields:    
    24. Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2-null mice, a model of Rett syndrome. Neurobiol Dis. 2018 Jan; 109(Pt A):25-32. Chen CY, Di Lucente J, Lin YC, Lien CC, Rogawski MA, Maezawa I, Jin LW. PMID: 28927958; PMCID: PMC5696074.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    25. The Anti-Amyloid-β and Neuroprotective Properties of a Novel Tricyclic Pyrone Molecule. J Alzheimers Dis. 2017; 58(2):559-574. Maezawa I, Zou B, Di Lucente J, Cao WS, Pascual C, Weerasekara S, Zhang M, Xie XS, Hua DH, Jin LW. PMID: 28482635; PMCID: PMC5438482.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    26. A Metal-Free Method for Producing MRI Contrast at Amyloid-β. J Alzheimers Dis. 2017; 55(4):1667-1681. Hilt S, Tang T, Walton JH, Budamagunta M, Maezawa I, Kálai T, Hideg K, Singh V, Wulff H, Gong Q, Jin LW, Louie A, Voss JC. PMID: 27911291; PMCID: PMC5718836.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    27. Differential Kv1.3, KCa3.1, and Kir2.1 expression in "classically" and "alternatively" activated microglia. Glia. 2017 01; 65(1):106-121. Nguyen HM, Grössinger EM, Horiuchi M, Davis KW, Jin LW, Maezawa I, Wulff H. PMID: 27696527; PMCID: PMC5113690.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    28. CX3CR1 ablation ameliorates motor and respiratory dysfunctions and improves survival of a Rett syndrome mouse model. Brain Behav Immun. 2017 Feb; 60:106-116. Horiuchi M, Smith L, Maezawa I, Jin LW. PMID: 26883520; PMCID: PMC5531048.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    29. Dendrites in Autism Spectrum Disorders. . 2016 Jan 1; 525-543. Martínez-Cerdeño MV, Maezawa MI, Jin JL. .
      View in: Publisher Site   Mentions:
    30. The potassium channel KCa3.1 constitutes a pharmacological target for neuroinflammation associated with ischemia/reperfusion stroke. J Cereb Blood Flow Metab. 2016 12; 36(12):2146-2161. Chen YJ, Nguyen HM, Maezawa I, Grössinger EM, Garing AL, Köhler R, Jin LW, Wulff H. PMID: 26661208; PMCID: PMC5363659.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    31. Protective spin-labeled fluorenes maintain amyloid beta peptide in small oligomers and limit transitions in secondary structure. Biochim Biophys Acta. 2015 Dec; 1854(12):1860-1870. Altman R, Ly S, Hilt S, Petrlova J, Maezawa I, Kálai T, Hideg K, Jin LW, Laurence TA, Voss JC. PMID: 26374940; PMCID: PMC4631661.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    32. Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's Disease. EBioMedicine. 2015 Apr 01; 2(4):294-305. Zhang L, Zhang S, Maezawa I, Trushin S, Minhas P, Pinto M, Jin LW, Prasain K, Nguyen TD, Yamazaki Y, Kanekiyo T, Bu G, Gateno B, Chang KO, Nath KA, Nemutlu E, Dzeja P, Pang YP, Hua DH, Trushina E. PMID: 26086035; PMCID: PMC4465115.
      View in: PubMed   Mentions: 51     Fields:    
    33. Dysregulation of glutamine transporter SNAT1 in Rett syndrome microglia: a mechanism for mitochondrial dysfunction and neurotoxicity. J Neurosci. 2015 Feb 11; 35(6):2516-29. Jin LW, Horiuchi M, Wulff H, Liu XB, Cortopassi GA, Erickson JD, Maezawa I. PMID: 25673846; PMCID: PMC4323531.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    34. Tomoregulin (TMEFF2) Binds Alzheimer's Disease Amyloid-β (Aβ) Oligomer and AβPP and Protects Neurons from Aβ-Induced Toxicity. J Alzheimers Dis. 2015; 48(3):731-43. Hong HS, Maezawa I, Petrlova J, Zhao XY, C Voss J, Jin LW. PMID: 26402097; PMCID: PMC5533101.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    35. Syntheses of 3-[(Alkylamino)methylene]-6-methylpyridine-2,4(1H,3H)-diones, 3-Substituted 7-Methyl-2H-pyrano[3,2-c]pyridine-2,5(6H)-dione Fluorescence Probes, and Tetrahydro-1H,9H-2,10-dioxa-9-azaanthracen-1-ones. Synthesis (Stuttg). 2014 Aug; 46(16):2179-2190. Prior AM, Gunaratna MJ, Kikuchi D, Desper J, Kim Y, Chang KO, Maezawa I, Jin LW, Hua DH. PMID: 25177061; PMCID: PMC4146570.
      View in: PubMed   Mentions:
    36. Syntheses, neural protective activities, and inhibition of glycogen synthase kinase-3β of substituted quinolines. Bioorg Med Chem Lett. 2014 Aug 01; 24(15):3392-7. Lu J, Maezawa I, Weerasekara S, Erenler R, Nguyen TD, Nguyen J, Swisher LZ, Li J, Jin LW, Ranjan A, Srivastava SK, Hua DH. PMID: 24951331; PMCID: PMC4110911.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    37. Synthesis and functional survey of new Tacrine analogs modified with nitroxides or their precursors. Eur J Med Chem. 2014 Apr 22; 77:343-50. Kálai T, Altman R, Maezawa I, Balog M, Morisseau C, Petrlova J, Hammock BD, Jin LW, Trudell JR, Voss JC, Hideg K. PMID: 24657571; PMCID: PMC4065883.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    38. Neurodevelopmental and Neuropsychiatric Disorders. . 2014 Jan 1; 345-372. Monji MA, Maezawa MI, Mizoguchi MY, Kato KT, Jin JL. .
      View in: Publisher Site   Mentions:
    39. MeCP2 modulates gene expression pathways in astrocytes. Mol Autism. 2013 Jan 25; 4(1):3. Yasui DH, Xu H, Dunaway KW, Lasalle JM, Jin LW, Maezawa I. PMID: 23351786; PMCID: PMC3561260.
      View in: PubMed   Mentions: 56     Fields:    
    40. Inhibition of Acyl-CoA: cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloid β (Aβ) oligomers-induced neuronal cell death by tricyclic pyrone molecules. J Med Chem. 2012 Oct 25; 55(20):8969-73. Pokhrel L, Maezawa I, Nguyen TD, Chang KO, Jin LW, Hua DH. PMID: 23025824; PMCID: PMC3486708.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    41. Microglial KCa3.1 Channels as a Potential Therapeutic Target for Alzheimer's Disease. Int J Alzheimers Dis. 2012; 2012:868972. Maezawa I, Jenkins DP, Jin BE, Wulff H. PMID: 22675649; PMCID: PMC3364551.
      View in: PubMed   Mentions: 39  
    42. The influence of spin-labeled fluorene compounds on the assembly and toxicity of the aβ peptide. PLoS One. 2012; 7(4):e35443. Petrlova J, Kálai T, Maezawa I, Altman R, Harishchandra G, Hong HS, Bricarello DA, Parikh AN, Lorigan GA, Jin LW, Hideg K, Voss JC. PMID: 22558151; PMCID: PMC3340382.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    43. Does microglial dysfunction play a role in autism and Rett syndrome? Neuron Glia Biol. 2011 Feb; 7(1):85-97. Maezawa I, Calafiore M, Wulff H, Jin LW. PMID: 22717189; PMCID: PMC4976478.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    44. Neuropathologic features in the hippocampus and cerebellum of three older men with fragile X syndrome. Mol Autism. 2011 Feb 08; 2(1):2. Greco CM, Navarro CS, Hunsaker MR, Maezawa I, Shuler JF, Tassone F, Delany M, Au JW, Berman RF, Jin LW, Schumann C, Hagerman PJ, Hagerman RJ. PMID: 21303513; PMCID: PMC3045897.
      View in: PubMed   Mentions: 36     Fields:    
    45. Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity. J Biol Chem. 2011 Feb 04; 286(5):3693-706. Maezawa I, Zimin PI, Wulff H, Jin LW. PMID: 20971854; PMCID: PMC3030372.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansAnimalsCells
    46. Amyloid β1-42 oligomer inhibits myelin sheet formation in vitro. Neurobiol Aging. 2012 Mar; 33(3):499-509. Horiuchi M, Maezawa I, Itoh A, Wakayama K, Jin LW, Itoh T, Decarli C. PMID: 20594620; PMCID: PMC3013291.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    47. Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate. J Neurosci. 2010 Apr 14; 30(15):5346-56. Maezawa I, Jin LW. PMID: 20392956; PMCID: PMC5533099.
      View in: PubMed   Mentions: 186     Fields:    Translation:AnimalsCells
    48. Rett syndrome astrocytes are abnormal and spread MeCP2 deficiency through gap junctions. J Neurosci. 2009 Apr 22; 29(16):5051-61. Maezawa I, Swanberg S, Harvey D, LaSalle JM, Jin LW. PMID: 19386901; PMCID: PMC3436907.
      View in: PubMed   Mentions: 160     Fields:    Translation:HumansAnimalsCells
    49. Candidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agents. Neurobiol Aging. 2010 Oct; 31(10):1690-9. Hong HS, Maezawa I, Budamagunta M, Rana S, Shi A, Vassar R, Liu R, Lam KS, Cheng RH, Hua DH, Voss JC, Jin LW. PMID: 19022536; PMCID: PMC2888733.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    50. Congo red and thioflavin-T analogs detect Abeta oligomers. J Neurochem. 2008 Jan; 104(2):457-68. Maezawa I, Hong HS, Liu R, Wu CY, Cheng RH, Kung MP, Kung HF, Lam KS, Oddo S, Laferla FM, Jin LW. PMID: 17953662.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansCells
    51. Combining the rapid MTT formazan exocytosis assay and the MC65 protection assay led to the discovery of carbazole analogs as small molecule inhibitors of Abeta oligomer-induced cytotoxicity. Brain Res. 2007 Jan 26; 1130(1):223-34. Hong HS, Maezawa I, Yao N, Xu B, Diaz-Avalos R, Rana S, Hua DH, Cheng RH, Lam KS, Jin LW. PMID: 17157826; PMCID: PMC1880896.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    52. Apolipoprotein E isoform-dependent dendritic recovery of hippocampal neurons following activation of innate immunity. J Neuroinflammation. 2006 Aug 25; 3:21. Maezawa I, Zaja-Milatovic S, Milatovic D, Stephen C, Sokal I, Maeda N, Montine TJ, Montine KS. PMID: 16934151; PMCID: PMC1584222.
      View in: PubMed   Mentions: 26     Fields:    
    53. Tumor necrosis factor alpha and interleukin 10 promoter region polymorphisms and risk of late-onset Alzheimer disease. Arch Neurol. 2006 Aug; 63(8):1165-9. Ramos EM, Lin MT, Larson EB, Maezawa I, Tseng LH, Edwards KL, Schellenberg GD, Hansen JA, Kukull WA, Jin LW. PMID: 16908746.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    54. A novel tricyclic pyrone compound ameliorates cell death associated with intracellular amyloid-beta oligomeric complexes. J Neurochem. 2006 Jul; 98(1):57-67. Maezawa I, Hong HS, Wu HC, Battina SK, Rana S, Iwamoto T, Radke GA, Pettersson E, Martin GM, Hua DH, Jin LW. PMID: 16805796.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    55. Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice. J Neuroinflammation. 2006 Apr 07; 3:10. Maezawa I, Maeda N, Montine TJ, Montine KS. PMID: 16603079; PMCID: PMC1502133.
      View in: PubMed   Mentions: 46     Fields:    
    56. Neurotoxicity from innate immune response is greatest with targeted replacement of E4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK. FASEB J. 2006 Apr; 20(6):797-9. Maezawa I, Nivison M, Montine KS, Maeda N, Montine TJ. PMID: 16481366.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    57. Polarimetric imaging of amyloid. Micron. 2006; 37(4):324-38. Kaminksy W, Jin LW, Powell S, Maezawa I, Claborn K, Branham C, Kahr B. PMID: 16406217.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    58. Role of glutathione in intracellular amyloid-alpha precursor protein/carboxy-terminal fragment aggregation and associated cytotoxicity. J Neurochem. 2005 May; 93(4):1047-56. Woltjer RL, Nghiem W, Maezawa I, Milatovic D, Vaisar T, Montine KS, Montine TJ. PMID: 15857408.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    59. Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carboxy terminal fragment-associated cytotoxicity. J Neurochem. 2004 Dec; 91(6):1312-21. Maezawa I, Jin LW, Woltjer RL, Maeda N, Martin GM, Montine TJ, Montine KS. PMID: 15584908.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    60. Oxidized low-density lipoprotein is present in astrocytes surrounding cerebral infarcts and stimulates astrocyte interleukin-6 secretion. Am J Pathol. 2004 Apr; 164(4):1173-81. Shie FS, Neely MD, Maezawa I, Wu H, Olson SJ, Jürgens G, Montine KS, Montine TJ. PMID: 15039206; PMCID: PMC1615328.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    61. Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities. Am J Pathol. 2004 Mar; 164(3):975-85. Jin LW, Shie FS, Maezawa I, Vincent I, Bird T. PMID: 14982851; PMCID: PMC1614713.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    62. Imaging linear birefringence and dichroism in cerebral amyloid pathologies. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15294-8. Jin LW, Claborn KA, Kurimoto M, Geday MA, Maezawa I, Sohraby F, Estrada M, Kaminksy W, Kahr B. PMID: 14668440; PMCID: PMC307560.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    63. Advanced glycation endproduct precursor alters intracellular amyloid-beta/A beta PP carboxy-terminal fragment aggregation and cytotoxicity. J Alzheimers Dis. 2003 Dec; 5(6):467-76. Woltjer RL, Maezawa I, Ou JJ, Montine KS, Montine TJ. PMID: 14757937.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    64. Alterations of chaperone protein expression in presenilin mutant neurons in response to glutamate excitotoxicity. Pathol Int. 2002 Sep; 52(9):551-4. Maezawa I, Wang B, Hu Q, Martin GM, Jin LW, Oshima J. PMID: 12406183.
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    65. Novel tricyclic pyrone compounds prevent intracellular APP C99-induced cell death. J Mol Neurosci. 2002 Aug-Oct; 19(1-2):57-61. Jin LW, Hua DH, Shie FS, Maezawa I, Sopher B, Martin GM. PMID: 12212794.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
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