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Gino A Cortopassi, PhD; BS

Title(s)Professor, School of Veterinary Medicine
SchoolUniversity of California, Davis
Address3007 VM3B
CA 95616
Phone530-754-9665
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Novel idebenone analogs block Shc's access to insulin receptor to improve insulin sensitivity. Biomed Pharmacother. 2020 Oct 10; 132:110823. Hui C, Tomilov A, Garcia C, Jiang X, Fash DM, Khdour OM, Rosso C, Filippini G, Prato M, Graham J, Hecht S, Havel P, Cortopassi G. PMID: 33045613.
      View in: PubMed   Mentions:    Fields:    
    2. Non-phagocytic Activation of NOX2 is Implicated in Progressive Non-alcoholic Steatohepatitis During Aging. Hepatology. 2020 Jan 17. Jiang JX, Fish SR, Tomilov A, Li Y, Fan W, Dehnad A, Gae D, Das S, Mozes G, Charville GW, Ramsey J, Cortopassi G, Török NJ. PMID: 31950520.
      View in: PubMed   Mentions: 2     Fields:    
    3. PPARa-targeted mitochondrial bioenergetics mediate repair of intestinal barriers at the host-microbe intersection during SIV infection. Proc Natl Acad Sci U S A. 2019 12 03; 116(49):24819-24829. Crakes KR, Santos Rocha C, Grishina I, Hirao LA, Napoli E, Gaulke CA, Fenton A, Datta S, Arredondo J, Marco ML, Sankaran-Walters S, Cortopassi G, Giulivi C, Dandekar S. PMID: 31740620.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Potential biomarker identification for Friedreich's ataxia using overlapping gene expression patterns in patient cells and mouse dorsal root ganglion. PLoS One. 2019; 14(10):e0223209. McMackin MZ, Durbin-Johnson B, Napierala M, Napierala JS, Ruiz L, Napoli E, Perlman S, Giulivi C, Cortopassi GA. PMID: 31665133.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. Cetylpyridinium chloride is a potent AMP-activated kinase (AMPK) inducer and has therapeutic potential in cancer. Mitochondrion. 2020 01; 50:19-24. Allen SA, Datta S, Sandoval J, Tomilov A, Sears T, Woolard K, Angelastro JM, Cortopassi GA. PMID: 31654752.
      View in: PubMed   Mentions: 1     Fields:    
    6. Dimethyl fumarate dosing in humans increases frataxin expression: A potential therapy for Friedreich's Ataxia. PLoS One. 2019; 14(6):e0217776. Jasoliya M, Sacca F, Sahdeo S, Chedin F, Pane C, Brescia Morra V, Filla A, Pook M, Cortopassi G. PMID: 31158268.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    7. Idebenone is a cytoprotective insulin sensitizer whose mechanism is Shc inhibition. Pharmacol Res. 2018 11; 137:89-103. Tomilov A, Allen S, Hui CK, Bettaieb A, Cortopassi G. PMID: 30290222.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    8. Small molecules bind human mTOR protein and inhibit mTORC1 specifically. Biochem Pharmacol. 2018 09; 155:298-304. Allen SA, Tomilov A, Cortopassi GA. PMID: 30028993.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice. Cell Metab. 2018 May 01; 27(5):1156. Roberts MN, Wallace MA, Tomilov AA, Zhou Z, Marcotte GR, Tran D, Perez G, Gutierrez-Casado E, Koike S, Knotts TA, Imai DM, Griffey SM, Kim K, Hagopian K, McMackin MZ, Haj FG, Baar K, Cortopassi GA, Ramsey JJ, Lopez-Dominguez JA. PMID: 29719228.
      View in: PubMed   Mentions: 5     Fields:    
    10. An innate immune response and altered nuclear receptor activation defines the spinal cord transcriptome during alpha-tocopherol deficiency in Ttpa-null mice. Free Radic Biol Med. 2018 05 20; 120:289-302. Finno CJ, Bordbari MH, Gianino G, Ming-Whitfield B, Burns E, Merkel J, Britton M, Durbin-Johnson B, Sloma EA, McMackin M, Cortopassi G, Rivas V, Barro M, Tran CK, Gennity I, Habib H, Xu L, Puschner B, Miller AD. PMID: 29526809.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    11. Rescue of cell death and inflammation of a mouse model of complex 1-mediated vision loss by repurposed drug molecules. Hum Mol Genet. 2017 12 15; 26(24):4929-4936. Yu AK, Datta S, McMackin MZ, Cortopassi GA. PMID: 29040550.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    12. Disruption of mitochondrial function as mechanism for anti-cancer activity of a novel mitochondriotropic menadione derivative. Toxicology. 2018 01 15; 393:123-139. Teixeira J, Amorim R, Santos K, Soares P, Datta S, Cortopassi GA, Serafim TL, Sardão VA, Garrido J, Borges F, Oliveira PJ. PMID: 29141199.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    13. A descriptive pilot study of cytokine production following stimulation of ex-vivo whole blood with commercial therapeutic feline hydrolyzed diets in individual healthy immunotolerant cats. BMC Vet Res. 2017 Oct 06; 13(1):297. Kathrani A, Larsen JA, Cortopassi G, Datta S, Fascetti AJ. PMID: 28985721.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    14. A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice. Cell Metab. 2017 Sep 05; 26(3):539-546.e5. Roberts MN, Wallace MA, Tomilov AA, Zhou Z, Marcotte GR, Tran D, Perez G, Gutierrez-Casado E, Koike S, Knotts TA, Imai DM, Griffey SM, Kim K, Hagopian K, McMackin MZ, Haj FG, Baar K, Cortopassi GA, Ramsey JJ, Lopez-Dominguez JA. PMID: 28877457.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    15. In Vitro Evaluation of Mitochondrial Function and Estrogen Signaling in Cell Lines Exposed to the Antiseptic Cetylpyridinium Chloride. Environ Health Perspect. 2017 08 22; 125(8):087015. Datta S, He G, Tomilov A, Sahdeo S, Denison MS, Cortopassi G. PMID: 28885978.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    16. Dimethyl fumarate mediates Nrf2-dependent mitochondrial biogenesis in mice and humans. Hum Mol Genet. 2017 08 01; 26(15):2864-2873. Hayashi G, Jasoliya M, Sahdeo S, Saccà F, Pane C, Filla A, Marsili A, Puorro G, Lanzillo R, Brescia Morra V, Cortopassi G. PMID: 28460056.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    17. Frataxin deficiency impairs mitochondrial biogenesis in cells, mice and humans. Hum Mol Genet. 2017 07 15; 26(14):2627-2633. Jasoliya MJ, McMackin MZ, Henderson CK, Perlman SL, Cortopassi GA. PMID: 28444186.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    18. Synthesis and biochemical characterization of EGF receptor in a water-soluble membrane model system. PLoS One. 2017; 12(6):e0177761. Scharadin TM, He W, Yiannakou Y, Tomilov AA, Saldana M, Cortopassi GA, Carraway KL, Coleman MA, Henderson PT. PMID: 28586369.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    19. The Eye Drop Preservative Benzalkonium Chloride Potently Induces Mitochondrial Dysfunction and Preferentially Affects LHON Mutant Cells. Invest Ophthalmol Vis Sci. 2017 04 01; 58(4):2406-2412. Datta S, Baudouin C, Brignole-Baudouin F, Denoyer A, Cortopassi GA. PMID: 28444329.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    20. Sperm Mitochondrial Function is Affected by Stallion Age and Predicts Post-Thaw Motility. Journal of Equine Veterinary Science. 2017 Mar 1; 50:52-61. Christa R. Darr, Luis E. Moraes, Tawny N. Scanlan, Julie Baumber-Skaife, Paul R. Loomis, Gino A. Cortopassi, Stuart A. Meyers. .
      View in: Publisher Site   Mentions:
    21. Parkin deficiency accelerates consequences of mitochondrial DNA deletions and Parkinsonism. Neurobiol Dis. 2017 Apr; 100:30-38. Song L, McMackin M, Nguyen A, Cortopassi G. PMID: 28042097.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    22. Bipolar cell reduction precedes retinal ganglion neuron loss in a complex 1 knockout mouse model. Brain Res. 2017 02 15; 1657:232-244. Song L, Yu A, Murray K, Cortopassi G. PMID: 28027875.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    23. A high-throughput screen for mitochondrial function reveals known and novel mitochondrial toxicants in a library of environmental agents. Mitochondrion. 2016 Nov; 31:79-83. Datta S, Sahdeo S, Gray JA, Morriseau C, Hammock BD, Cortopassi G. PMID: 27717841.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    24. Galectin-3 regulates inflammasome activation in cholestatic liver injury. FASEB J. 2016 12; 30(12):4202-4213. Tian J, Yang G, Chen HY, Hsu DK, Tomilov A, Olson KA, Dehnad A, Fish SR, Cortopassi G, Zhao B, Liu FT, Gershwin ME, Török NJ, Jiang JX. PMID: 27630169.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    25. Neurobehavioral deficits in the KIKO mouse model of Friedreich's ataxia. Behav Brain Res. 2017 01 01; 316:183-188. McMackin MZ, Henderson CK, Cortopassi GA. PMID: 27575947.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    26. Identification of small molecules that improve ATP synthesis defects conferred by Leber's hereditary optic neuropathy mutations. Mitochondrion. 2016 09; 30:177-86. Datta S, Tomilov A, Cortopassi G. PMID: 27497748.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    27. Mice with low levels of Shc proteins display reduced glycolytic and increased gluconeogenic activities in liver. Biochem Biophys Rep. 2016 Sep; 7:273-286. Hagopian K, Kim K, López-Dominguez JA, Tomilov AA, Cortopassi GA, Ramsey JJ. PMID: 28133633.
      View in: PubMed   Mentions:
    28. Lactate and Pyruvate Are Major Sources of Energy for Stallion Sperm with Dose Effects on Mitochondrial Function, Motility, and ROS Production. Biol Reprod. 2016 08; 95(2):34. Darr CR, Varner DD, Teague S, Cortopassi GA, Datta S, Meyers SA. PMID: 27335066.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    29. Mitochondrial oxygen consumption is a unique indicator of stallion spermatozoal health and varies with cryopreservation media. Theriogenology. 2016 Sep 15; 86(5):1382-92. Darr CR, Cortopassi GA, Datta S, Varner DD, Meyers SA. PMID: 27242178.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    30. Lymphoblast Oxidative Stress Genes as Potential Biomarkers of Disease Severity and Drug Effect in Friedreich's Ataxia. PLoS One. 2016; 11(4):e0153574. Hayashi G, Cortopassi G. PMID: 27078885.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    31. p46Shc Inhibits Thiolase and Lipid Oxidation in Mitochondria. J Biol Chem. 2016 Jun 10; 291(24):12575-85. Tomilov A, Tomilova N, Shan Y, Hagopian K, Bettaieb A, Kim K, Pelicci PG, Haj F, Ramsey J, Cortopassi G. PMID: 27059956.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    32. Frataxin Deficiency Promotes Excess Microglial DNA Damage and Inflammation that Is Rescued by PJ34. PLoS One. 2016; 11(3):e0151026. Shen Y, McMackin MZ, Shan Y, Raetz A, David S, Cortopassi G. PMID: 26954031.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    33. Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly. Mitochondrion. 2016 Jan; 26:94-103. Shan Y, Cortopassi G. PMID: 26702583.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    34. Oxidative stress in inherited mitochondrial diseases. Free Radic Biol Med. 2015 Nov; 88(Pt A):10-7. Hayashi G, Cortopassi G. PMID: 26073122.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    35. Key glycolytic enzyme activities of skeletal muscle are decreased under fed and fasted states in mice with knocked down levels of Shc proteins. PLoS One. 2015; 10(4):e0124204. Hagopian K, Tomilov AA, Kim K, Cortopassi GA, Ramsey JJ. PMID: 25880638.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    36. Dysregulation of glutamine transporter SNAT1 in Rett syndrome microglia: a mechanism for mitochondrial dysfunction and neurotoxicity. J Neurosci. 2015 Feb 11; 35(6):2516-29. Jin LW, Horiuchi M, Wulff H, Liu XB, Cortopassi GA, Erickson JD, Maezawa I. PMID: 25673846.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    37. Mitochondrial complex I deficiency leads to inflammation and retinal ganglion cell death in the Ndufs4 mouse. Hum Mol Genet. 2015 May 15; 24(10):2848-60. Yu AK, Song L, Murray KD, van der List D, Sun C, Shen Y, Xia Z, Cortopassi GA. PMID: 25652399.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    38. Mitochondrial complex I defects increase ubiquitin in substantia nigra. Brain Res. 2015 Jan 12; 1594:82-91. Song L, Cortopassi G. PMID: 25446449.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    39. Shc depletion stimulates brown fat activity in vivo and in vitro. Aging Cell. 2014 Dec; 13(6):1049-58. Tomilov A, Bettaieb A, Kim K, Sahdeo S, Tomilova N, Lam A, Hagopian K, Connell M, Fong J, Rowland D, Griffey S, Ramsey J, Haj F, Cortopassi G. PMID: 25257068.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    40. Dyclonine rescues frataxin deficiency in animal models and buccal cells of patients with Friedreich's ataxia. Hum Mol Genet. 2014 Dec 20; 23(25):6848-62. Sahdeo S, Scott BD, McMackin MZ, Jasoliya M, Brown B, Wulff H, Perlman SL, Pook MA, Cortopassi GA. PMID: 25113747.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    41. Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia. Hum Mol Genet. 2014 Dec 20; 23(25):6838-47. Hayashi G, Shen Y, Pedersen TL, Newman JW, Pook M, Cortopassi G. PMID: 25104852.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    42. High-throughput screening of FDA-approved drugs using oxygen biosensor plates reveals secondary mitofunctional effects. Mitochondrion. 2014 Jul; 17:116-25. Sahdeo S, Tomilov A, Komachi K, Iwahashi C, Datta S, Hughes O, Hagerman P, Cortopassi G. PMID: 25034306.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    43. The influence of Shc proteins on life span in mice. J Gerontol A Biol Sci Med Sci. 2014 Oct; 69(10):1177-85. Ramsey JJ, Tran D, Giorgio M, Griffey SM, Koehne A, Laing ST, Taylor SL, Kim K, Cortopassi GA, Lloyd KC, Hagopian K, Tomilov AA, Migliaccio E, Pelicci PG, McDonald RB. PMID: 24336818.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    44. Frataxin deficiency leads to defects in expression of antioxidants and Nrf2 expression in dorsal root ganglia of the Friedreich's ataxia YG8R mouse model. Antioxid Redox Signal. 2013 Nov 01; 19(13):1481-93. Shan Y, Schoenfeld RA, Hayashi G, Napoli E, Akiyama T, Iodi Carstens M, Carstens EE, Pook MA, Cortopassi GA. PMID: 23350650.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    45. Effects of alkyl side chain modification of coenzyme Q10 on mitochondrial respiratory chain function and cytoprotection. Bioorg Med Chem. 2013 Apr 15; 21(8):2346-2354. Fash DM, Khdour OM, Sahdeo SJ, Goldschmidt R, Jaruvangsanti J, Dey S, Arce PM, Collin VC, Cortopassi GA, Hecht SM. PMID: 23473946.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    46. Development of an HTS assay for EPHX2 phosphatase activity and screening of nontargeted libraries. Anal Biochem. 2013 Mar 01; 434(1):105-11. Morisseau C, Sahdeo S, Cortopassi G, Hammock BD. PMID: 23219563.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    47. OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability. J Am Heart Assoc. 2012 Oct; 1(5):e003012. Chen L, Liu T, Tran A, Lu X, Tomilov AA, Davies V, Cortopassi G, Chiamvimonvat N, Bers DM, Votruba M, Knowlton AA. PMID: 23316298.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    48. Mutant Twinkle increases dopaminergic neurodegeneration, mtDNA deletions and modulates Parkin expression. Hum Mol Genet. 2012 Dec 01; 21(23):5147-58. Song L, Shan Y, Lloyd KC, Cortopassi GA. PMID: 22949510.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    49. Shc proteins influence the activities of enzymes involved in fatty acid oxidation and ketogenesis. Metabolism. 2012 Dec; 61(12):1703-13. Hagopian K, Tomilov AA, Tomilova N, Kim K, Taylor SL, Lam AK, Cortopassi GA, McDonald RB, Ramsey JJ. PMID: 22683097.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    50. Hepatic Src homology phosphatase 2 regulates energy balance in mice. Endocrinology. 2012 Jul; 153(7):3158-69. Nagata N, Matsuo K, Bettaieb A, Bakke J, Matsuo I, Graham J, Xi Y, Liu S, Tomilov A, Tomilova N, Gray S, Jung DY, Ramsey JJ, Kim JK, Cortopassi G, Havel PJ, Haj FG. PMID: 22619361.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    51. The p66Shc knocked out mice are short lived under natural condition. Aging Cell. 2012 Feb; 11(1):162-8. Giorgio M, Berry A, Berniakovich I, Poletaeva I, Trinei M, Stendardo M, Hagopian K, Ramsey JJ, Cortopassi G, Migliaccio E, Nötzli S, Amrein I, Lipp HP, Cirulli F, Pelicci PG. PMID: 22081964.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    52. HSC20 interacts with frataxin and is involved in iron-sulfur cluster biogenesis and iron homeostasis. Hum Mol Genet. 2012 Apr 01; 21(7):1457-69. Shan Y, Cortopassi G. PMID: 22171070.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    53. The Shc locus regulates insulin signaling and adiposity in mammals. Aging Cell. 2011 Feb; 10(1):55-65. Tomilov AA, Ramsey JJ, Hagopian K, Giorgio M, Kim KM, Lam A, Migliaccio E, Lloyd KC, Berniakovich I, Prolla TA, Pelicci P, Cortopassi GA. PMID: 21040401.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    54. Synthesis and characterization of mitoQ and idebenone analogues as mediators of oxygen consumption in mitochondria. Bioorg Med Chem. 2010 Sep 01; 18(17):6429-41. Duveau DY, Arce PM, Schoenfeld RA, Raghav N, Cortopassi GA, Hecht SM. PMID: 20691600.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    55. Oligodendroglial differentiation induces mitochondrial genes and inhibition of mitochondrial function represses oligodendroglial differentiation. Mitochondrion. 2010 Mar; 10(2):143-50. Schoenfeld R, Wong A, Silva J, Li M, Itoh A, Horiuchi M, Itoh T, Pleasure D, Cortopassi G. PMID: 20005986.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    56. Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice. J Biol Chem. 2010 Jan 08; 285(2):1153-65. Tomilov AA, Bicocca V, Schoenfeld RA, Giorgio M, Migliaccio E, Ramsey JJ, Hagopian K, Pelicci PG, Cortopassi GA. PMID: 19892704.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    57. Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. J Biol Chem. 2010 Jan 01; 285(1):142-52. Chowanadisai W, Bauerly KA, Tchaparian E, Wong A, Cortopassi GA, Rucker RB. PMID: 19861415.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    58. Frataxin deficiency induces Schwann cell inflammation and death. Biochim Biophys Acta. 2009 Nov; 1792(11):1052-61. Lu C, Schoenfeld R, Shan Y, Tsai HJ, Hammock B, Cortopassi G. PMID: 19679182.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    59. Inhibition of mitochondrial function induces an integrated stress response in oligodendroglia. Neurobiol Dis. 2009 May; 34(2):357-65. Silva JM, Wong A, Carelli V, Cortopassi GA. PMID: 19233273.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    60. Biosensor plates detect mitochondrial physiological regulators and mutations in vivo. Anal Biochem. 2009 Feb 01; 385(1):176-8. Rolo AP, Palmeira CM, Cortopassi GA. PMID: 18950600.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    61. Cell functions impaired by frataxin deficiency are restored by drug-mediated iron relocation. Blood. 2008 Dec 15; 112(13):5219-27. Kakhlon O, Manning H, Breuer W, Melamed-Book N, Lu C, Cortopassi G, Munnich A, Cabantchik ZI. PMID: 18796625.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    62. Mitochondrial DNA deletions induce the adenosine monophosphate-activated protein kinase energy stress pathway and result in decreased secretion of some proteins. Aging Cell. 2007 Oct; 6(5):619-30. Prigione A, Cortopassi G. PMID: 17651460.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    63. Mitochondrial DNA deletions and chloramphenicol treatment stimulate the autophagic transcript ATG12. Autophagy. 2007 Jul-Aug; 3(4):377-80. Prigione A, Cortopassi G. PMID: 17457038.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    64. Hemin rescues adrenodoxin, heme a and cytochrome oxidase activity in frataxin-deficient oligodendroglioma cells. Biochim Biophys Acta. 2007 Jul; 1772(7):773-80. Napoli E, Morin D, Bernhardt R, Buckpitt A, Cortopassi G. PMID: 17499976.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    65. Mitochondrial frataxin interacts with ISD11 of the NFS1/ISCU complex and multiple mitochondrial chaperones. Hum Mol Genet. 2007 Apr 15; 16(8):929-41. Shan Y, Napoli E, Cortopassi G. PMID: 17331979.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    66. Frataxin knockdown causes loss of cytoplasmic iron-sulfur cluster functions, redox alterations and induction of heme transcripts. Arch Biochem Biophys. 2007 Jan 01; 457(1):111-22. Lu C, Cortopassi G. PMID: 17098208.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    67. Mitochondrial DNA deletions inhibit proteasomal activity and stimulate an autophagic transcript. Free Radic Biol Med. 2007 Jan 01; 42(1):32-43. Alemi M, Prigione A, Wong A, Schoenfeld R, DiMauro S, Hirano M, Taroni F, Cortopassi G. PMID: 17157191.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    68. Mitochondrial disease activates transcripts of the unfolded protein response and cell cycle and inhibits vesicular secretion and oligodendrocyte-specific transcripts. Mitochondrion. 2006 Aug; 6(4):161-75. Cortopassi G, Danielson S, Alemi M, Zhan SS, Tong W, Carelli V, Martinuzzi A, Marzuki S, Majamaa K, Wong A. PMID: 16815102.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    69. Frataxin, iron-sulfur clusters, heme, ROS, and aging. Antioxid Redox Signal. 2006 Mar-Apr; 8(3-4):506-16. Napoli E, Taroni F, Cortopassi GA. PMID: 16677095.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    70. A low dose of ethidium bromide leads to an increase of total mitochondrial DNA while higher concentrations induce the mtDNA 4997 deletion in a human neuronal cell line. Mutat Res. 2006 Apr 11; 596(1-2):57-63. von Wurmb-Schwark N, Cavelier L, Cortopassi GA. PMID: 16488450.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    71. Frataxin deficiency alters heme pathway transcripts and decreases mitochondrial heme metabolites in mammalian cells. Hum Mol Genet. 2005 Dec 15; 14(24):3787-99. Schoenfeld RA, Napoli E, Wong A, Zhan S, Reutenauer L, Morin D, Buckpitt AR, Taroni F, Lonnerdal B, Ristow M, Puccio H, Cortopassi GA. PMID: 16239244.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    72. Isolation of transcriptomal changes attributable to LHON mutations and the cybridization process. Brain. 2005 May; 128(Pt 5):1026-37. Danielson SR, Carelli V, Tan G, Martinuzzi A, Schapira AH, Savontaus ML, Cortopassi GA. PMID: 15728653.
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    73. Decreased expression of genes involved in sulfur amino acid metabolism in frataxin-deficient cells. Hum Mol Genet. 2003 Jul 15; 12(14):1699-711. Tan G, Napoli E, Taroni F, Cortopassi G. PMID: 12837693.
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    74. High-throughput measurement of mitochondrial membrane potential in a neural cell line using a fluorescence plate reader. Biochem Biophys Res Commun. 2002 Nov 15; 298(5):750-4. Wong A, Cortopassi GA. PMID: 12419317.
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    75. A neutral theory predicts multigenic aging and increased concentrations of deleterious mutations on the mitochondrial and Y chromosomes. Free Radic Biol Med. 2002 Sep 01; 33(5):605-10. Cortopassi GA. PMID: 12208346.
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    76. Fixation of deleterious alleles, evolution and human aging. Mech Ageing Dev. 2002 Apr 30; 123(8):851-5. Cortopassi GA. PMID: 12044933.
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    77. Quantification of human mitochondrial DNA in a real time PCR. Forensic Sci Int. 2002 Mar 28; 126(1):34-9. von Wurmb-Schwark N, Higuchi R, Fenech AP, Elfstroem C, Meissner C, Oehmichen M, Cortopassi GA. PMID: 11955829.
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    78. Differentiation-specific effects of LHON mutations introduced into neuronal NT2 cells. Hum Mol Genet. 2002 Feb 15; 11(4):431-8. Wong A, Cavelier L, Collins-Schramm HE, Seldin MF, McGrogan M, Savontaus ML, Cortopassi GA. PMID: 11854175.
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    79. Reproducible quantitative PCR of mitochondrial and nuclear DNA copy number using the LightCycler. Methods Mol Biol. 2002; 197:129-37. Wong A, Cortopassi G. PMID: 12013791.
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    80. Cells bearing mutations causing Leber's hereditary optic neuropathy are sensitized to Fas-Induced apoptosis. J Biol Chem. 2002 Feb 22; 277(8):5810-5. Danielson SR, Wong A, Carelli V, Martinuzzi A, Schapira AH, Cortopassi GA. PMID: 11741983.
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    81. Frataxin expression rescues mitochondrial dysfunctions in FRDA cells. Hum Mol Genet. 2001 Sep 15; 10(19):2099-107. Tan G, Chen LS, Lonnerdal B, Gellera C, Taroni FA, Cortopassi GA. PMID: 11590127.
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    82. Cellular characterization of leukotoxin diol-induced mitochondrial dysfunction. Arch Biochem Biophys. 2001 Aug 01; 392(1):32-7. Sisemore MF, Zheng J, Yang JC, Thompson DA, Plopper CG, Cortopassi GA, Hammock BD. PMID: 11469791.
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    83. Genetic basis for susceptibility to noise-induced hearing loss in mice. Hear Res. 2001 May; 155(1-2):82-90. Davis RR, Newlander JK, Ling X, Cortopassi GA, Krieg EF, Erway LC. PMID: 11335078.
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    84. Mitochondrial defects and hearing loss. Cell Mol Life Sci. 2000 Dec; 57(13-14):1927-37. Hutchin TP, Cortopassi GA. PMID: 11215518.
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    85. Bcl-2 does not inhibit the permeability transition pore in mouse liver mitochondria. Toxicology. 2000 Oct 26; 151(1-3):65-72. Yang JC, Kahn A, Cortopassi G. PMID: 11074301.
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    86. Sensitivity of FRDA lymphoblasts to salts of transition metal ions. Antioxid Redox Signal. 2000; 2(3):461-5. Wong A, Yang J, Danielson S, Gellera C, Taroni F, Cortopassi G. PMID: 11229359.
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    87. Frequencies of hprt(-) mutations and bcl-2 translocations in circulating human lymphocytes are correlated with United Kingdom sunlight records. Mutagenesis. 1999 Nov; 14(6):527-32. Bentham G, Wolfreys AM, Liu Y, Cortopassi G, Green MH, Arlett CF, Cole J. PMID: 10567026.
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    88. The Friedreich's ataxia mutation confers cellular sensitivity to oxidant stress which is rescued by chelators of iron and calcium and inhibitors of apoptosis. Hum Mol Genet. 1999 Mar; 8(3):425-30. Wong A, Yang J, Cavadini P, Gellera C, Lonnerdal B, Taroni F, Cortopassi G. PMID: 9949201.
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    89. Mitochondria in organismal aging and degeneration. Biochim Biophys Acta. 1999 Feb 09; 1410(2):183-93. Cortopassi GA, Wong A. PMID: 10076026.
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    90. dATP causes specific release of cytochrome C from mitochondria. Biochem Biophys Res Commun. 1998 Sep 18; 250(2):454-7. Yang JC, Cortopassi GA. PMID: 9753651.
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    91. Analysis of oxygen consumption and mitochondrial permeability with age in mice. Mech Ageing Dev. 1998 Apr 01; 101(3):245-56. Goodell S, Cortopassi G. PMID: 9622228.
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    92. Induction of the mitochondrial permeability transition causes release of the apoptogenic factor cytochrome c. Free Radic Biol Med. 1998 Mar 01; 24(4):624-31. Yang JC, Cortopassi GA. PMID: 9559874.
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    93. Familial streptomycin ototoxicity in a South African family: a mitochondrial disorder. J Med Genet. 1997 Nov; 34(11):904-6. Gardner JC, Goliath R, Viljoen D, Sellars S, Cortopassi G, Hutchin T, Greenberg J, Beighton P. PMID: 9391883.
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    94. Frequency of Bcl-2 rearrangements in peripheral blood of HIV-infected individuals. Br J Haematol. 1997 Nov; 99(2):465-6. Liu Y, Cortopassi G, Goedert JJ, Rabkin CS. PMID: 9375775.
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    95. mtDNA mutations confer cellular sensitivity to oxidant stress that is partially rescued by calcium depletion and cyclosporin A. Biochem Biophys Res Commun. 1997 Oct 09; 239(1):139-45. Wong A, Cortopassi G. PMID: 9345284.
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    96. The rate of mitochondrial mutagenesis is faster in mice than humans. Mutat Res. 1997 Jul 03; 377(2):157-66. Wang E, Wong A, Cortopassi G. PMID: 9247611.
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    97. Mitochondria-mediated cell injury. Symposium overview. Fundam Appl Toxicol. 1997 Jul; 38(1):23-37. Wallace KB, Eells JT, Madeira VM, Cortopassi G, Jones DP. PMID: 9268603.
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    98. Multiple origins of a mitochondrial mutation conferring deafness. Genetics. 1997 Mar; 145(3):771-6. Hutchin TP, Cortopassi GA. PMID: 9055086.
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    99. Correlated mutagenesis of bcl2 and hprt loci in blood lymphocytes. Environ Mol Mutagen. 1997; 29(1):36-45. Liu Y, Cortopassi G, Steingrimsdottir H, Waugh AP, Beare DM, Green MH, Robinson DR, Cole J. PMID: 9020305.
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    100. There is substantial agreement among interspecies estimates of DNA repair activity. Mech Ageing Dev. 1996 Nov 13; 91(3):211-8. Cortopassi GA, Wang E. PMID: 9055244.
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    101. Topical gentamicin-induced hearing loss: a mitochondrial ribosomal RNA study of genetic susceptibility. Am J Otol. 1996 Nov; 17(6):850-2. Chen JM, Williamson PA, Hutchin T, Nedzelski JM, Cortopassi GA. PMID: 8915412.
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    102. The mutation rate of the human mtDNA deletion mtDNA4977. Am J Hum Genet. 1996 Oct; 59(4):772-80. Shenkar R, Navidi W, Tavaré S, Dang MH, Chomyn A, Attardi G, Cortopassi G, Arnheim N. PMID: 8808591.
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    103. Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria. Proc Natl Acad Sci U S A. 1996 Sep 03; 93(18):9893-8. Murphy AN, Bredesen DE, Cortopassi G, Wang E, Fiskum G. PMID: 8790427.
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    104. Lack of evidence for an association between the frequency of mutants or translocations in circulating lymphocytes and exposure to radon gas in the home. Radiat Res. 1996 Jan; 145(1):61-9. Cole J, Green MH, Bridges BA, Waugh AP, Beare DM, Henshaw D, Last R, Liu Y, Cortopassi G. PMID: 8532838.
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    105. Degeneration of human oncogenes and mitochondrial genes occurs in cells that exhibit age-related pathology. Exp Gerontol. 1996 Jan-Apr; 31(1-2):253-65. Cortopassi G, Liu Y, Hutchin T. PMID: 8706795.
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    106. Mitochondrial DNA haplotype predicts deafness risk. Am J Med Genet. 1995 Dec 18; 60(6):592. Hutchin T, Cortopassi G. PMID: 8825904.
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    107. Genotypic selection of mitochondrial and oncogenic mutations in human tissue suggests mechanisms of age-related pathophysiology. Mutat Res. 1995 Oct; 338(1-6):151-9. Cortopassi G, Liu Y. PMID: 7565870.
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    108. A mitochondrial DNA clone is associated with increased risk for Alzheimer disease. Proc Natl Acad Sci U S A. 1995 Jul 18; 92(15):6892-5. Hutchin T, Cortopassi G. PMID: 7624338.
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    109. Modelling the effects of age-related mtDNA mutation accumulation; complex I deficiency, superoxide and cell death. Biochim Biophys Acta. 1995 May 24; 1271(1):171-6. Cortopassi G, Wang E. PMID: 7599205.
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    110. Occurrence of bcl-2 oncogene translocation with increased frequency in the peripheral blood of heavy smokers. J Natl Cancer Inst. 1995 Feb 01; 87(3):223-4. Bell DA, Liu Y, Cortopassi GA. PMID: 7707410.
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    111. Proposed molecular and cellular mechanism for aminoglycoside ototoxicity. Antimicrob Agents Chemother. 1994 Nov; 38(11):2517-20. Hutchin T, Cortopassi G. PMID: 7872740.
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    112. BCL2 translocation frequency rises with age in humans. Proc Natl Acad Sci U S A. 1994 Sep 13; 91(19):8910-4. Liu Y, Hernandez AM, Shibata D, Cortopassi GA. PMID: 8090743.
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    113. Mice with duplications and deletions at the Tme locus have altered MnSOD activity. J Biol Chem. 1994 Sep 09; 269(36):22463-5. Wang E, Cortopassi G. PMID: 8077189.
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    114. A molecular and cellular hypothesis for aminoglycoside-induced deafness. Hear Res. 1994 Jul; 78(1):27-30. Cortopassi G, Hutchin T. PMID: 7961174.
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    116. Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafness. Nat Genet. 1993 Jul; 4(3):289-94. Prezant TR, Agapian JV, Bohlman MC, Bu X, Oztas S, Qiu WQ, Arnos KS, Cortopassi GA, Jaber L, Rotter JI. PMID: 7689389.
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    119. Deleterious mitochondrial DNA mutations accumulate in aging human tissues. Mutat Res. 1992 Sep; 275(3-6):157-67. Arnheim N, Cortopassi G. PMID: 1383758.
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    120. A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc Natl Acad Sci U S A. 1992 Aug 15; 89(16):7370-4. Cortopassi GA, Shibata D, Soong NW, Arnheim N. PMID: 1502147.
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    121. Genetic analysis of a switch in cell specificity of P lysozyme expression in molossinus mice. Genet Res. 1991 Oct; 58(2):111-4. Cortopassi GA, Wilson AC. PMID: 1765259.
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    122. Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acids Res. 1990 Dec 11; 18(23):6927-33. Cortopassi GA, Arnheim N. PMID: 2263455.
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    124. A simple method for site-directed mutagenesis using the polymerase chain reaction. Nucleic Acids Res. 1989 Aug 25; 17(16):6545-51. Hemsley A, Arnheim N, Toney MD, Cortopassi G, Galas DJ. PMID: 2674899.
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    125. Deficient repair of chemical adducts in alpha DNA of monkey cells. Cell. 1982 Mar; 28(3):613-9. Zolan ME, Cortopassi GA, Smith CA, Hanawalt PC. PMID: 7074686.
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