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Gino A Cortopassi

Title(s)Professor, SCHOOL OF VETERINARY MEDICINE
SchoolUniversity of California, Davis
Phone530-754-9665
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. McMackin MZ, Durbin-Johnson B, Napierala M, Napierala JS, Ruiz L, Napoli E, Perlman S, Giulivi C, Cortopassi GA. Potential biomarker identification for Friedreich's ataxia using overlapping gene expression patterns in patient cells and mouse dorsal root ganglion. PLoS One. 2019; 14(10):e0223209. PMID: 31665133.
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    2. Allen SA, Datta S, Sandoval J, Tomilov A, Sears T, Woolard K, Angelastro JM, Cortopassi GA. Cetylpyridinium chloride is a potent AMP-activated kinase (AMPK) inducer and has therapeutic potential in cancer. Mitochondrion. 2019 Oct 22; 50:19-24. PMID: 31654752.
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    3. Jasoliya M, Sacca F, Sahdeo S, Chedin F, Pane C, Brescia Morra V, Filla A, Pook M, Cortopassi G. Dimethyl fumarate dosing in humans increases frataxin expression: A potential therapy for Friedreich's Ataxia. PLoS One. 2019; 14(6):e0217776. PMID: 31158268.
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    4. Tomilov A, Allen S, Hui CK, Bettaieb A, Cortopassi G. Idebenone is a cytoprotective insulin sensitizer whose mechanism is Shc inhibition. Pharmacol Res. 2018 11; 137:89-103. PMID: 30290222.
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    5. Allen SA, Tomilov A, Cortopassi GA. Small molecules bind human mTOR protein and inhibit mTORC1 specifically. Biochem Pharmacol. 2018 09; 155:298-304. PMID: 30028993.
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    6. Roberts MN, Wallace MA, Tomilov AA, Zhou Z, Marcotte GR, Tran D, Perez G, Gutierrez-Casado E, Koike S, Knotts TA, Imai DM, Griffey SM, Kim K, Hagopian K, McMackin MZ, Haj FG, Baar K, Cortopassi GA, Ramsey JJ, Lopez-Dominguez JA. A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice. Cell Metab. 2018 05 01; 27(5):1156. PMID: 29719228.
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    7. Finno CJ, Bordbari MH, Gianino G, Ming-Whitfield B, Burns E, Merkel J, Britton M, Durbin-Johnson B, Sloma EA, McMackin M, Cortopassi G, Rivas V, Barro M, Tran CK, Gennity I, Habib H, Xu L, Puschner B, Miller AD. An innate immune response and altered nuclear receptor activation defines the spinal cord transcriptome during alpha-tocopherol deficiency in Ttpa-null mice. Free Radic Biol Med. 2018 05 20; 120:289-302. PMID: 29526809.
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    8. Yu AK, Datta S, McMackin MZ, Cortopassi GA. Rescue of cell death and inflammation of a mouse model of complex 1-mediated vision loss by repurposed drug molecules. Hum Mol Genet. 2017 12 15; 26(24):4929-4936. PMID: 29040550.
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    9. Teixeira J, Amorim R, Santos K, Soares P, Datta S, Cortopassi GA, Serafim TL, Sardão VA, Garrido J, Borges F, Oliveira PJ. Disruption of mitochondrial function as mechanism for anti-cancer activity of a novel mitochondriotropic menadione derivative. Toxicology. 2018 01 15; 393:123-139. PMID: 29141199.
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    10. Kathrani A, Larsen JA, Cortopassi G, Datta S, Fascetti AJ. A descriptive pilot study of cytokine production following stimulation of ex-vivo whole blood with commercial therapeutic feline hydrolyzed diets in individual healthy immunotolerant cats. BMC Vet Res. 2017 Oct 06; 13(1):297. PMID: 28985721.
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    11. Roberts MN, Wallace MA, Tomilov AA, Zhou Z, Marcotte GR, Tran D, Perez G, Gutierrez-Casado E, Koike S, Knotts TA, Imai DM, Griffey SM, Kim K, Hagopian K, McMackin MZ, Haj FG, Baar K, Cortopassi GA, Ramsey JJ, Lopez-Dominguez JA. A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice. Cell Metab. 2017 Sep 05; 26(3):539-546.e5. PMID: 28877457.
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    12. Datta S, He G, Tomilov A, Sahdeo S, Denison MS, Cortopassi G. In Vitro Evaluation of Mitochondrial Function and Estrogen Signaling in Cell Lines Exposed to the Antiseptic Cetylpyridinium Chloride. Environ Health Perspect. 2017 08 22; 125(8):087015. PMID: 28885978.
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    13. Hayashi G, Jasoliya M, Sahdeo S, Saccà F, Pane C, Filla A, Marsili A, Puorro G, Lanzillo R, Brescia Morra V, Cortopassi G. Dimethyl fumarate mediates Nrf2-dependent mitochondrial biogenesis in mice and humans. Hum Mol Genet. 2017 08 01; 26(15):2864-2873. PMID: 28460056.
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    14. Jasoliya MJ, McMackin MZ, Henderson CK, Perlman SL, Cortopassi GA. Frataxin deficiency impairs mitochondrial biogenesis in cells, mice and humans. Hum Mol Genet. 2017 07 15; 26(14):2627-2633. PMID: 28444186.
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    15. Scharadin TM, He W, Yiannakou Y, Tomilov AA, Saldana M, Cortopassi GA, Carraway KL, Coleman MA, Henderson PT. Synthesis and biochemical characterization of EGF receptor in a water-soluble membrane model system. PLoS One. 2017; 12(6):e0177761. PMID: 28586369.
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    16. Datta S, Baudouin C, Brignole-Baudouin F, Denoyer A, Cortopassi GA. The Eye Drop Preservative Benzalkonium Chloride Potently Induces Mitochondrial Dysfunction and Preferentially Affects LHON Mutant Cells. Invest Ophthalmol Vis Sci. 2017 04 01; 58(4):2406-2412. PMID: 28444329.
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    17. Song L, McMackin M, Nguyen A, Cortopassi G. Parkin deficiency accelerates consequences of mitochondrial DNA deletions and Parkinsonism. Neurobiol Dis. 2017 Apr; 100:30-38. PMID: 28042097.
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    18. Song L, Yu A, Murray K, Cortopassi G. Bipolar cell reduction precedes retinal ganglion neuron loss in a complex 1 knockout mouse model. Brain Res. 2017 02 15; 1657:232-244. PMID: 28027875.
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    19. Datta S, Sahdeo S, Gray JA, Morriseau C, Hammock BD, Cortopassi G. A high-throughput screen for mitochondrial function reveals known and novel mitochondrial toxicants in a library of environmental agents. Mitochondrion. 2016 Nov; 31:79-83. PMID: 27717841.
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    20. Tian J, Yang G, Chen HY, Hsu DK, Tomilov A, Olson KA, Dehnad A, Fish SR, Cortopassi G, Zhao B, Liu FT, Gershwin ME, Török NJ, Jiang JX. Galectin-3 regulates inflammasome activation in cholestatic liver injury. FASEB J. 2016 12; 30(12):4202-4213. PMID: 27630169.
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    21. McMackin MZ, Henderson CK, Cortopassi GA. Neurobehavioral deficits in the KIKO mouse model of Friedreich's ataxia. Behav Brain Res. 2017 01 01; 316:183-188. PMID: 27575947.
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    22. Datta S, Tomilov A, Cortopassi G. Identification of small molecules that improve ATP synthesis defects conferred by Leber's hereditary optic neuropathy mutations. Mitochondrion. 2016 09; 30:177-86. PMID: 27497748.
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    23. Hagopian K, Kim K, López-Dominguez JA, Tomilov AA, Cortopassi GA, Ramsey JJ. Mice with low levels of Shc proteins display reduced glycolytic and increased gluconeogenic activities in liver. Biochem Biophys Rep. 2016 Sep; 7:273-286. PMID: 28133633.
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    24. Darr CR, Varner DD, Teague S, Cortopassi GA, Datta S, Meyers SA. Lactate and Pyruvate Are Major Sources of Energy for Stallion Sperm with Dose Effects on Mitochondrial Function, Motility, and ROS Production. Biol Reprod. 2016 08; 95(2):34. PMID: 27335066.
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    25. Darr CR, Cortopassi GA, Datta S, Varner DD, Meyers SA. Mitochondrial oxygen consumption is a unique indicator of stallion spermatozoal health and varies with cryopreservation media. Theriogenology. 2016 Sep 15; 86(5):1382-92. PMID: 27242178.
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    26. Hayashi G, Cortopassi G. Lymphoblast Oxidative Stress Genes as Potential Biomarkers of Disease Severity and Drug Effect in Friedreich's Ataxia. PLoS One. 2016; 11(4):e0153574. PMID: 27078885.
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    27. Tomilov A, Tomilova N, Shan Y, Hagopian K, Bettaieb A, Kim K, Pelicci PG, Haj F, Ramsey J, Cortopassi G. p46Shc Inhibits Thiolase and Lipid Oxidation in Mitochondria. J Biol Chem. 2016 Jun 10; 291(24):12575-85. PMID: 27059956.
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    28. Shen Y, McMackin MZ, Shan Y, Raetz A, David S, Cortopassi G. Frataxin Deficiency Promotes Excess Microglial DNA Damage and Inflammation that Is Rescued by PJ34. PLoS One. 2016; 11(3):e0151026. PMID: 26954031.
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    29. Shan Y, Cortopassi G. Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly. Mitochondrion. 2016 Jan; 26:94-103. PMID: 26702583.
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    30. Hayashi G, Cortopassi G. Oxidative stress in inherited mitochondrial diseases. Free Radic Biol Med. 2015 Nov; 88(Pt A):10-7. PMID: 26073122.
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    31. Hagopian K, Tomilov AA, Kim K, Cortopassi GA, Ramsey JJ. Key glycolytic enzyme activities of skeletal muscle are decreased under fed and fasted states in mice with knocked down levels of Shc proteins. PLoS One. 2015; 10(4):e0124204. PMID: 25880638.
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    32. Jin LW, Horiuchi M, Wulff H, Liu XB, Cortopassi GA, Erickson JD, Maezawa I. Dysregulation of glutamine transporter SNAT1 in Rett syndrome microglia: a mechanism for mitochondrial dysfunction and neurotoxicity. J Neurosci. 2015 Feb 11; 35(6):2516-29. PMID: 25673846.
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    33. Yu AK, Song L, Murray KD, van der List D, Sun C, Shen Y, Xia Z, Cortopassi GA. Mitochondrial complex I deficiency leads to inflammation and retinal ganglion cell death in the Ndufs4 mouse. Hum Mol Genet. 2015 May 15; 24(10):2848-60. PMID: 25652399.
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    34. Song L, Cortopassi G. Mitochondrial complex I defects increase ubiquitin in substantia nigra. Brain Res. 2015 Jan 12; 1594:82-91. PMID: 25446449.
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    35. Tomilov A, Bettaieb A, Kim K, Sahdeo S, Tomilova N, Lam A, Hagopian K, Connell M, Fong J, Rowland D, Griffey S, Ramsey J, Haj F, Cortopassi G. Shc depletion stimulates brown fat activity in vivo and in vitro. Aging Cell. 2014 Dec; 13(6):1049-58. PMID: 25257068.
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    36. Sahdeo S, Scott BD, McMackin MZ, Jasoliya M, Brown B, Wulff H, Perlman SL, Pook MA, Cortopassi GA. Dyclonine rescues frataxin deficiency in animal models and buccal cells of patients with Friedreich's ataxia. Hum Mol Genet. 2014 Dec 20; 23(25):6848-62. PMID: 25113747.
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    37. Hayashi G, Shen Y, Pedersen TL, Newman JW, Pook M, Cortopassi G. Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia. Hum Mol Genet. 2014 Dec 20; 23(25):6838-47. PMID: 25104852.
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    38. Sahdeo S, Tomilov A, Komachi K, Iwahashi C, Datta S, Hughes O, Hagerman P, Cortopassi G. High-throughput screening of FDA-approved drugs using oxygen biosensor plates reveals secondary mitofunctional effects. Mitochondrion. 2014 Jul; 17:116-25. PMID: 25034306.
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    39. Ramsey JJ, Tran D, Giorgio M, Griffey SM, Koehne A, Laing ST, Taylor SL, Kim K, Cortopassi GA, Lloyd KC, Hagopian K, Tomilov AA, Migliaccio E, Pelicci PG, McDonald RB. The influence of Shc proteins on life span in mice. J Gerontol A Biol Sci Med Sci. 2014 Oct; 69(10):1177-85. PMID: 24336818.
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    40. Shan Y, Schoenfeld RA, Hayashi G, Napoli E, Akiyama T, Iodi Carstens M, Carstens EE, Pook MA, Cortopassi GA. Frataxin deficiency leads to defects in expression of antioxidants and Nrf2 expression in dorsal root ganglia of the Friedreich's ataxia YG8R mouse model. Antioxid Redox Signal. 2013 Nov 01; 19(13):1481-93. PMID: 23350650.
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    41. Fash DM, Khdour OM, Sahdeo SJ, Goldschmidt R, Jaruvangsanti J, Dey S, Arce PM, Collin VC, Cortopassi GA, Hecht SM. Effects of alkyl side chain modification of coenzyme Q10 on mitochondrial respiratory chain function and cytoprotection. Bioorg Med Chem. 2013 Apr 15; 21(8):2346-2354. PMID: 23473946.
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    42. Morisseau C, Sahdeo S, Cortopassi G, Hammock BD. Development of an HTS assay for EPHX2 phosphatase activity and screening of nontargeted libraries. Anal Biochem. 2013 Mar 01; 434(1):105-11. PMID: 23219563.
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    43. Chen L, Liu T, Tran A, Lu X, Tomilov AA, Davies V, Cortopassi G, Chiamvimonvat N, Bers DM, Votruba M, Knowlton AA. OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability. J Am Heart Assoc. 2012 Oct; 1(5):e003012. PMID: 23316298.
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    44. Song L, Shan Y, Lloyd KC, Cortopassi GA. Mutant Twinkle increases dopaminergic neurodegeneration, mtDNA deletions and modulates Parkin expression. Hum Mol Genet. 2012 Dec 01; 21(23):5147-58. PMID: 22949510.
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    45. Hagopian K, Tomilov AA, Tomilova N, Kim K, Taylor SL, Lam AK, Cortopassi GA, McDonald RB, Ramsey JJ. Shc proteins influence the activities of enzymes involved in fatty acid oxidation and ketogenesis. Metabolism. 2012 Dec; 61(12):1703-13. PMID: 22683097.
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    46. Nagata N, Matsuo K, Bettaieb A, Bakke J, Matsuo I, Graham J, Xi Y, Liu S, Tomilov A, Tomilova N, Gray S, Jung DY, Ramsey JJ, Kim JK, Cortopassi G, Havel PJ, Haj FG. Hepatic Src homology phosphatase 2 regulates energy balance in mice. Endocrinology. 2012 Jul; 153(7):3158-69. PMID: 22619361.
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    47. Giorgio M, Berry A, Berniakovich I, Poletaeva I, Trinei M, Stendardo M, Hagopian K, Ramsey JJ, Cortopassi G, Migliaccio E, Nötzli S, Amrein I, Lipp HP, Cirulli F, Pelicci PG. The p66Shc knocked out mice are short lived under natural condition. Aging Cell. 2012 Feb; 11(1):162-8. PMID: 22081964.
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    48. Shan Y, Cortopassi G. HSC20 interacts with frataxin and is involved in iron-sulfur cluster biogenesis and iron homeostasis. Hum Mol Genet. 2012 Apr 01; 21(7):1457-69. PMID: 22171070.
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    49. Tomilov AA, Ramsey JJ, Hagopian K, Giorgio M, Kim KM, Lam A, Migliaccio E, Lloyd KC, Berniakovich I, Prolla TA, Pelicci P, Cortopassi GA. The Shc locus regulates insulin signaling and adiposity in mammals. Aging Cell. 2011 Feb; 10(1):55-65. PMID: 21040401.
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    50. Duveau DY, Arce PM, Schoenfeld RA, Raghav N, Cortopassi GA, Hecht SM. Synthesis and characterization of mitoQ and idebenone analogues as mediators of oxygen consumption in mitochondria. Bioorg Med Chem. 2010 Sep 01; 18(17):6429-41. PMID: 20691600.
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    51. Schoenfeld R, Wong A, Silva J, Li M, Itoh A, Horiuchi M, Itoh T, Pleasure D, Cortopassi G. Oligodendroglial differentiation induces mitochondrial genes and inhibition of mitochondrial function represses oligodendroglial differentiation. Mitochondrion. 2010 Mar; 10(2):143-50. PMID: 20005986.
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    52. Tomilov AA, Bicocca V, Schoenfeld RA, Giorgio M, Migliaccio E, Ramsey JJ, Hagopian K, Pelicci PG, Cortopassi GA. Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice. J Biol Chem. 2010 Jan 08; 285(2):1153-65. PMID: 19892704.
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    53. Chowanadisai W, Bauerly KA, Tchaparian E, Wong A, Cortopassi GA, Rucker RB. Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. J Biol Chem. 2010 Jan 01; 285(1):142-52. PMID: 19861415.
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    54. Lu C, Schoenfeld R, Shan Y, Tsai HJ, Hammock B, Cortopassi G. Frataxin deficiency induces Schwann cell inflammation and death. Biochim Biophys Acta. 2009 Nov; 1792(11):1052-61. PMID: 19679182.
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    55. Silva JM, Wong A, Carelli V, Cortopassi GA. Inhibition of mitochondrial function induces an integrated stress response in oligodendroglia. Neurobiol Dis. 2009 May; 34(2):357-65. PMID: 19233273.
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    56. Rolo AP, Palmeira CM, Cortopassi GA. Biosensor plates detect mitochondrial physiological regulators and mutations in vivo. Anal Biochem. 2009 Feb 01; 385(1):176-8. PMID: 18950600.
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    57. Kakhlon O, Manning H, Breuer W, Melamed-Book N, Lu C, Cortopassi G, Munnich A, Cabantchik ZI. Cell functions impaired by frataxin deficiency are restored by drug-mediated iron relocation. Blood. 2008 Dec 15; 112(13):5219-27. PMID: 18796625.
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    58. Prigione A, Cortopassi G. Mitochondrial DNA deletions induce the adenosine monophosphate-activated protein kinase energy stress pathway and result in decreased secretion of some proteins. Aging Cell. 2007 Oct; 6(5):619-30. PMID: 17651460.
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    59. Prigione A, Cortopassi G. Mitochondrial DNA deletions and chloramphenicol treatment stimulate the autophagic transcript ATG12. Autophagy. 2007 Jul-Aug; 3(4):377-80. PMID: 17457038.
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    60. Napoli E, Morin D, Bernhardt R, Buckpitt A, Cortopassi G. Hemin rescues adrenodoxin, heme a and cytochrome oxidase activity in frataxin-deficient oligodendroglioma cells. Biochim Biophys Acta. 2007 Jul; 1772(7):773-80. PMID: 17499976.
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    61. Shan Y, Napoli E, Cortopassi G. Mitochondrial frataxin interacts with ISD11 of the NFS1/ISCU complex and multiple mitochondrial chaperones. Hum Mol Genet. 2007 Apr 15; 16(8):929-41. PMID: 17331979.
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    62. Lu C, Cortopassi G. Frataxin knockdown causes loss of cytoplasmic iron-sulfur cluster functions, redox alterations and induction of heme transcripts. Arch Biochem Biophys. 2007 Jan 01; 457(1):111-22. PMID: 17098208.
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    63. Alemi M, Prigione A, Wong A, Schoenfeld R, DiMauro S, Hirano M, Taroni F, Cortopassi G. Mitochondrial DNA deletions inhibit proteasomal activity and stimulate an autophagic transcript. Free Radic Biol Med. 2007 Jan 01; 42(1):32-43. PMID: 17157191.
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    64. Cortopassi G, Danielson S, Alemi M, Zhan SS, Tong W, Carelli V, Martinuzzi A, Marzuki S, Majamaa K, Wong A. Mitochondrial disease activates transcripts of the unfolded protein response and cell cycle and inhibits vesicular secretion and oligodendrocyte-specific transcripts. Mitochondrion. 2006 Aug; 6(4):161-75. PMID: 16815102.
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    65. Napoli E, Taroni F, Cortopassi GA. Frataxin, iron-sulfur clusters, heme, ROS, and aging. Antioxid Redox Signal. 2006 Mar-Apr; 8(3-4):506-16. PMID: 16677095.
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    66. von Wurmb-Schwark N, Cavelier L, Cortopassi GA. A low dose of ethidium bromide leads to an increase of total mitochondrial DNA while higher concentrations induce the mtDNA 4997 deletion in a human neuronal cell line. Mutat Res. 2006 Apr 11; 596(1-2):57-63. PMID: 16488450.
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    67. Schoenfeld RA, Napoli E, Wong A, Zhan S, Reutenauer L, Morin D, Buckpitt AR, Taroni F, Lonnerdal B, Ristow M, Puccio H, Cortopassi GA. Frataxin deficiency alters heme pathway transcripts and decreases mitochondrial heme metabolites in mammalian cells. Hum Mol Genet. 2005 Dec 15; 14(24):3787-99. PMID: 16239244.
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    68. Danielson SR, Carelli V, Tan G, Martinuzzi A, Schapira AH, Savontaus ML, Cortopassi GA. Isolation of transcriptomal changes attributable to LHON mutations and the cybridization process. Brain. 2005 May; 128(Pt 5):1026-37. PMID: 15728653.
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    69. Tan G, Napoli E, Taroni F, Cortopassi G. Decreased expression of genes involved in sulfur amino acid metabolism in frataxin-deficient cells. Hum Mol Genet. 2003 Jul 15; 12(14):1699-711. PMID: 12837693.
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    70. Wong A, Cortopassi GA. High-throughput measurement of mitochondrial membrane potential in a neural cell line using a fluorescence plate reader. Biochem Biophys Res Commun. 2002 Nov 15; 298(5):750-4. PMID: 12419317.
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    71. Cortopassi GA. A neutral theory predicts multigenic aging and increased concentrations of deleterious mutations on the mitochondrial and Y chromosomes. Free Radic Biol Med. 2002 Sep 01; 33(5):605-10. PMID: 12208346.
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    72. Cortopassi GA. Fixation of deleterious alleles, evolution and human aging. Mech Ageing Dev. 2002 Apr 30; 123(8):851-5. PMID: 12044933.
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    73. von Wurmb-Schwark N, Higuchi R, Fenech AP, Elfstroem C, Meissner C, Oehmichen M, Cortopassi GA. Quantification of human mitochondrial DNA in a real time PCR. Forensic Sci Int. 2002 Mar 28; 126(1):34-9. PMID: 11955829.
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    74. Wong A, Cavelier L, Collins-Schramm HE, Seldin MF, McGrogan M, Savontaus ML, Cortopassi GA. Differentiation-specific effects of LHON mutations introduced into neuronal NT2 cells. Hum Mol Genet. 2002 Feb 15; 11(4):431-8. PMID: 11854175.
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    75. Wong A, Cortopassi G. Reproducible quantitative PCR of mitochondrial and nuclear DNA copy number using the LightCycler. Methods Mol Biol. 2002; 197:129-37. PMID: 12013791.
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    76. Danielson SR, Wong A, Carelli V, Martinuzzi A, Schapira AH, Cortopassi GA. Cells bearing mutations causing Leber's hereditary optic neuropathy are sensitized to Fas-Induced apoptosis. J Biol Chem. 2002 Feb 22; 277(8):5810-5. PMID: 11741983.
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    77. Tan G, Chen LS, Lonnerdal B, Gellera C, Taroni FA, Cortopassi GA. Frataxin expression rescues mitochondrial dysfunctions in FRDA cells. Hum Mol Genet. 2001 Sep 15; 10(19):2099-107. PMID: 11590127.
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    78. Sisemore MF, Zheng J, Yang JC, Thompson DA, Plopper CG, Cortopassi GA, Hammock BD. Cellular characterization of leukotoxin diol-induced mitochondrial dysfunction. Arch Biochem Biophys. 2001 Aug 01; 392(1):32-7. PMID: 11469791.
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    79. Davis RR, Newlander JK, Ling X, Cortopassi GA, Krieg EF, Erway LC. Genetic basis for susceptibility to noise-induced hearing loss in mice. Hear Res. 2001 May; 155(1-2):82-90. PMID: 11335078.
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    80. Hutchin TP, Cortopassi GA. Mitochondrial defects and hearing loss. Cell Mol Life Sci. 2000 Dec; 57(13-14):1927-37. PMID: 11215518.
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    81. Yang JC, Kahn A, Cortopassi G. Bcl-2 does not inhibit the permeability transition pore in mouse liver mitochondria. Toxicology. 2000 Oct 26; 151(1-3):65-72. PMID: 11074301.
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    82. Wong A, Yang J, Danielson S, Gellera C, Taroni F, Cortopassi G. Sensitivity of FRDA lymphoblasts to salts of transition metal ions. Antioxid Redox Signal. 2000; 2(3):461-5. PMID: 11229359.
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    83. Bentham G, Wolfreys AM, Liu Y, Cortopassi G, Green MH, Arlett CF, Cole J. Frequencies of hprt(-) mutations and bcl-2 translocations in circulating human lymphocytes are correlated with United Kingdom sunlight records. Mutagenesis. 1999 Nov; 14(6):527-32. PMID: 10567026.
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    84. Wong A, Yang J, Cavadini P, Gellera C, Lonnerdal B, Taroni F, Cortopassi G. The Friedreich's ataxia mutation confers cellular sensitivity to oxidant stress which is rescued by chelators of iron and calcium and inhibitors of apoptosis. Hum Mol Genet. 1999 Mar; 8(3):425-30. PMID: 9949201.
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    85. Cortopassi GA, Wong A. Mitochondria in organismal aging and degeneration. Biochim Biophys Acta. 1999 Feb 09; 1410(2):183-93. PMID: 10076026.
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    86. Yang JC, Cortopassi GA. dATP causes specific release of cytochrome C from mitochondria. Biochem Biophys Res Commun. 1998 Sep 18; 250(2):454-7. PMID: 9753651.
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    87. Goodell S, Cortopassi G. Analysis of oxygen consumption and mitochondrial permeability with age in mice. Mech Ageing Dev. 1998 Apr 01; 101(3):245-56. PMID: 9622228.
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    88. Yang JC, Cortopassi GA. Induction of the mitochondrial permeability transition causes release of the apoptogenic factor cytochrome c. Free Radic Biol Med. 1998 Mar 01; 24(4):624-31. PMID: 9559874.
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    89. Liu Y, Cortopassi G, Goedert JJ, Rabkin CS. Frequency of Bcl-2 rearrangements in peripheral blood of HIV-infected individuals. Br J Haematol. 1997 Nov; 99(2):465-6. PMID: 9375775.
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    90. Gardner JC, Goliath R, Viljoen D, Sellars S, Cortopassi G, Hutchin T, Greenberg J, Beighton P. Familial streptomycin ototoxicity in a South African family: a mitochondrial disorder. J Med Genet. 1997 Nov; 34(11):904-6. PMID: 9391883.
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    91. Wong A, Cortopassi G. mtDNA mutations confer cellular sensitivity to oxidant stress that is partially rescued by calcium depletion and cyclosporin A. Biochem Biophys Res Commun. 1997 Oct 09; 239(1):139-45. PMID: 9345284.
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    92. Wang E, Wong A, Cortopassi G. The rate of mitochondrial mutagenesis is faster in mice than humans. Mutat Res. 1997 Jul 03; 377(2):157-66. PMID: 9247611.
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    93. Wallace KB, Eells JT, Madeira VM, Cortopassi G, Jones DP. Mitochondria-mediated cell injury. Symposium overview. Fundam Appl Toxicol. 1997 Jul; 38(1):23-37. PMID: 9268603.
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    94. Hutchin TP, Cortopassi GA. Multiple origins of a mitochondrial mutation conferring deafness. Genetics. 1997 Mar; 145(3):771-6. PMID: 9055086.
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    95. Liu Y, Cortopassi G, Steingrimsdottir H, Waugh AP, Beare DM, Green MH, Robinson DR, Cole J. Correlated mutagenesis of bcl2 and hprt loci in blood lymphocytes. Environ Mol Mutagen. 1997; 29(1):36-45. PMID: 9020305.
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    96. Cortopassi GA, Wang E. There is substantial agreement among interspecies estimates of DNA repair activity. Mech Ageing Dev. 1996 Nov 13; 91(3):211-8. PMID: 9055244.
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    97. Chen JM, Williamson PA, Hutchin T, Nedzelski JM, Cortopassi GA. Topical gentamicin-induced hearing loss: a mitochondrial ribosomal RNA study of genetic susceptibility. Am J Otol. 1996 Nov; 17(6):850-2. PMID: 8915412.
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    98. Shenkar R, Navidi W, Tavaré S, Dang MH, Chomyn A, Attardi G, Cortopassi G, Arnheim N. The mutation rate of the human mtDNA deletion mtDNA4977. Am J Hum Genet. 1996 Oct; 59(4):772-80. PMID: 8808591.
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    99. Murphy AN, Bredesen DE, Cortopassi G, Wang E, Fiskum G. Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria. Proc Natl Acad Sci U S A. 1996 Sep 03; 93(18):9893-8. PMID: 8790427.
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    100. Cortopassi G, Liu Y, Hutchin T. Degeneration of human oncogenes and mitochondrial genes occurs in cells that exhibit age-related pathology. Exp Gerontol. 1996 Jan-Apr; 31(1-2):253-65. PMID: 8706795.
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    101. Cole J, Green MH, Bridges BA, Waugh AP, Beare DM, Henshaw D, Last R, Liu Y, Cortopassi G. Lack of evidence for an association between the frequency of mutants or translocations in circulating lymphocytes and exposure to radon gas in the home. Radiat Res. 1996 Jan; 145(1):61-9. PMID: 8532838.
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    102. Hutchin T, Cortopassi G. Mitochondrial DNA haplotype predicts deafness risk. Am J Med Genet. 1995 Dec 18; 60(6):592. PMID: 8825904.
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    104. Hutchin T, Cortopassi G. A mitochondrial DNA clone is associated with increased risk for Alzheimer disease. Proc Natl Acad Sci U S A. 1995 Jul 18; 92(15):6892-5. PMID: 7624338.
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    105. Cortopassi G, Wang E. Modelling the effects of age-related mtDNA mutation accumulation; complex I deficiency, superoxide and cell death. Biochim Biophys Acta. 1995 May 24; 1271(1):171-6. PMID: 7599205.
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    106. Bell DA, Liu Y, Cortopassi GA. Occurrence of bcl-2 oncogene translocation with increased frequency in the peripheral blood of heavy smokers. J Natl Cancer Inst. 1995 Feb 01; 87(3):223-4. PMID: 7707410.
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    107. Hutchin T, Cortopassi G. Proposed molecular and cellular mechanism for aminoglycoside ototoxicity. Antimicrob Agents Chemother. 1994 Nov; 38(11):2517-20. PMID: 7872740.
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    108. Liu Y, Hernandez AM, Shibata D, Cortopassi GA. BCL2 translocation frequency rises with age in humans. Proc Natl Acad Sci U S A. 1994 Sep 13; 91(19):8910-4. PMID: 8090743.
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    109. Wang E, Cortopassi G. Mice with duplications and deletions at the Tme locus have altered MnSOD activity. J Biol Chem. 1994 Sep 09; 269(36):22463-5. PMID: 8077189.
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    111. Hutchin T, Haworth I, Higashi K, Fischel-Ghodsian N, Stoneking M, Saha N, Arnos C, Cortopassi G. A molecular basis for human hypersensitivity to aminoglycoside antibiotics. Nucleic Acids Res. 1993 Sep 11; 21(18):4174-9. PMID: 8414970.
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    112. Prezant TR, Agapian JV, Bohlman MC, Bu X, Oztas S, Qiu WQ, Arnos KS, Cortopassi GA, Jaber L, Rotter JI. Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafness. Nat Genet. 1993 Jul; 4(3):289-94. PMID: 7689389.
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    113. Soong NW, Hinton DR, Cortopassi G, Arnheim N. Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. Nat Genet. 1992 Dec; 2(4):318-23. PMID: 1303287.
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    114. Cortopassi GA, Arnheim N. Using the polymerase chain reaction to estimate mutation frequencies and rates in human cells. Mutat Res. 1992 Sep; 277(3):239-49. PMID: 1381052.
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    115. Arnheim N, Cortopassi G. Deleterious mitochondrial DNA mutations accumulate in aging human tissues. Mutat Res. 1992 Sep; 275(3-6):157-67. PMID: 1383758.
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    117. Cortopassi GA, Wilson AC. Genetic analysis of a switch in cell specificity of P lysozyme expression in molossinus mice. Genet Res. 1991 Oct; 58(2):111-4. PMID: 1765259.
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    121. Zolan ME, Cortopassi GA, Smith CA, Hanawalt PC. Deficient repair of chemical adducts in alpha DNA of monkey cells. Cell. 1982 Mar; 28(3):613-9. PMID: 7074686.
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