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James M Angelastro

Title(s)Associate Professor, SCHOOL OF VETERINARY MEDICINE
SchoolUniversity of California, Davis
Phone530-752-1591
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    Collapse Research 
    Collapse Research Activities and Funding
    Using Cell-Penetrant Peptides to Target ATF5 in Mouse Glioma Models
    NIH/NINDS R01NS083795Feb 15, 2014 - Jan 31, 2019
    Role: Principal Investigator
    Elimination of Carcinogen-Induced Tumor Stem Cells by ATF5 Loss of Function.
    NIH/NCI R21CA126924Jul 1, 2008 - Jun 30, 2011
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sun X, Jefferson P, Zhou Q, Angelastro JM, Greene LA. Dominant-Negative ATF5 Compromises Cancer Cell Survival by Targeting CEBPB and CEBPD. Mol Cancer Res. 2019 Nov 01. PMID: 31676720.
      View in: PubMed
    2. Allen SA, Datta S, Sandoval J, Tomilov A, Sears T, Woolard K, Angelastro JM, Cortopassi GA. Cetylpyridinium chloride is a potent AMP-activated kinase (AMPK) inducer and has therapeutic potential in cancer. Mitochondrion. 2020 Jan; 50:19-24. PMID: 31654752.
      View in: PubMed
    3. Sun X, Angelastro JM, Merino D, Zhou Q, Siegelin MD, Greene LA. Dominant-negative ATF5 rapidly depletes survivin in tumor cells. Cell Death Dis. 2019 Sep 24; 10(10):709. PMID: 31551409.
      View in: PubMed
    4. Sears TK, Angelastro JM. The transcription factor ATF5: role in cellular differentiation, stress responses, and cancer. Oncotarget. 2017 Oct 13; 8(48):84595-84609. PMID: 29137451.
      View in: PubMed
    5. Angelastro JM. Targeting ATF5 in Cancer. Trends Cancer. 2017 07; 3(7):471-474. PMID: 28718401.
      View in: PubMed
    6. York D, Sproul CD, Chikere N, Dickinson PJ, Angelastro JM. Expression and targeting of transcription factor ATF5 in dog gliomas. Vet Comp Oncol. 2018 Mar; 16(1):102-107. PMID: 28480569.
      View in: PubMed
    7. Wald JH, Hatakeyama J, Printsev I, Cuevas A, Fry WHD, Saldana MJ, VanderVorst K, Rowson-Hodel A, Angelastro JM, Sweeney C, Carraway KL. Suppression of planar cell polarity signaling and migration in glioblastoma by Nrdp1-mediated Dvl polyubiquitination. Oncogene. 2017 09 07; 36(36):5158-5167. PMID: 28481871.
      View in: PubMed
    8. Karpel-Massler G, Horst BA, Shu C, Chau L, Tsujiuchi T, Bruce JN, Canoll P, Greene LA, Angelastro JM, Siegelin MD. A Synthetic Cell-Penetrating Dominant-Negative ATF5 Peptide Exerts Anticancer Activity against a Broad Spectrum of Treatment-Resistant Cancers. Clin Cancer Res. 2016 Sep 15; 22(18):4698-711. PMID: 27126996.
      View in: PubMed
    9. Cates CC, Arias AD, Nakayama Wong LS, Lamé MW, Sidorov M, Cayanan G, Rowland DJ, Fung J, Karpel-Massler G, Siegelin MD, Greene LA, Angelastro JM. Regression/eradication of gliomas in mice by a systemically-deliverable ATF5 dominant-negative peptide. Oncotarget. 2016 Mar 15; 7(11):12718-30. PMID: 26863637.
      View in: PubMed
    10. Napoli E, Ross-Inta C, Wong S, Hung C, Fujisawa Y, Sakaguchi D, Angelastro J, Omanska-Klusek A, Schoenfeld R, Giulivi C. Mitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53. PLoS One. 2012; 7(8):e42504. PMID: 22900024.
      View in: PubMed
    11. Lee HY, Angelastro JM, Kenney AM, Mason CA, Greene LA. Reciprocal actions of ATF5 and Shh in proliferation of cerebellar granule neuron progenitor cells. Dev Neurobiol. 2012 Jun; 72(6):789-804. PMID: 22095825.
      View in: PubMed
    12. Arias A, Lamé MW, Santarelli L, Hen R, Greene LA, Angelastro JM. Regulated ATF5 loss-of-function in adult mice blocks formation and causes regression/eradication of gliomas. Oncogene. 2012 Feb 09; 31(6):739-51. PMID: 21725368.
      View in: PubMed
    13. Cunningham CL, Martínez Cerdeño V, Navarro Porras E, Prakash AN, Angelastro JM, Willemsen R, Hagerman PJ, Pessah IN, Berman RF, Noctor SC. Premutation CGG-repeat expansion of the Fmr1 gene impairs mouse neocortical development. Hum Mol Genet. 2011 Jan 01; 20(1):64-79. PMID: 20935171.
      View in: PubMed
    14. Angelastro JM, Lamé MW. Overexpression of CD133 promotes drug resistance in C6 glioma cells. Mol Cancer Res. 2010 Aug; 8(8):1105-15. PMID: 20663862.
      View in: PubMed
    15. Li G, Li W, Angelastro JM, Greene LA, Liu DX. Identification of a novel DNA binding site and a transcriptional target for activating transcription factor 5 in c6 glioma and mcf-7 breast cancer cells. Mol Cancer Res. 2009 Jun; 7(6):933-43. PMID: 19531563.
      View in: PubMed
    16. Greene LA, Lee HY, Angelastro JM. The transcription factor ATF5: role in neurodevelopment and neural tumors. J Neurochem. 2009 Jan; 108(1):11-22. PMID: 19046351.
      View in: PubMed
    17. Schrot RJ, Ma JH, Greco CM, Arias AD, Angelastro JM. Organotypic distribution of stem cell markers in formalin-fixed brain harboring glioblastoma multiforme. J Neurooncol. 2007 Nov; 85(2):149-57. PMID: 17516028.
      View in: PubMed
    18. Monaco SE, Angelastro JM, Szabolcs M, Greene LA. The transcription factor ATF5 is widely expressed in carcinomas, and interference with its function selectively kills neoplastic, but not nontransformed, breast cell lines. Int J Cancer. 2007 May 01; 120(9):1883-90. PMID: 17266024.
      View in: PubMed
    19. Angelastro JM, Canoll PD, Kuo J, Weicker M, Costa A, Bruce JN, Greene LA. Selective destruction of glioblastoma cells by interference with the activity or expression of ATF5. Oncogene. 2006 Feb 09; 25(6):907-16. PMID: 16170340.
      View in: PubMed
    20. Greene LA, Angelastro JM. You can't go home again: transcriptionally driven alteration of cell signaling by NGF. Neurochem Res. 2005 Oct; 30(10):1347-52. PMID: 16341597.
      View in: PubMed
    21. Mason JL, Angelastro JM, Ignatova TN, Kukekov VG, Lin G, Greene LA, Goldman JE. ATF5 regulates the proliferation and differentiation of oligodendrocytes. Mol Cell Neurosci. 2005 Jul; 29(3):372-80. PMID: 15950153.
      View in: PubMed
    22. Angelastro JM, Mason JL, Ignatova TN, Kukekov VG, Stengren GB, Goldman JE, Greene LA. Downregulation of activating transcription factor 5 is required for differentiation of neural progenitor cells into astrocytes. J Neurosci. 2005 Apr 13; 25(15):3889-99. PMID: 15829641.
      View in: PubMed
    23. Ryu EJ, Angelastro JM, Greene LA. Analysis of gene expression changes in a cellular model of Parkinson disease. Neurobiol Dis. 2005 Feb; 18(1):54-74. PMID: 15649696.
      View in: PubMed
    24. Jabado O, Wang Q, Rideout HJ, Yeasmin M, Guo KX, Vekrellis K, Papantonis S, Angelastro JM, Troy CM, Stefanis L. RAIDD aggregation facilitates apoptotic death of PC12 cells and sympathetic neurons. Cell Death Differ. 2004 Jun; 11(6):618-30. PMID: 14765136.
      View in: PubMed
    25. Angelastro JM, Ignatova TN, Kukekov VG, Steindler DA, Stengren GB, Mendelsohn C, Greene LA. Regulated expression of ATF5 is required for the progression of neural progenitor cells to neurons. J Neurosci. 2003 Jun 01; 23(11):4590-600. PMID: 12805299.
      View in: PubMed
    26. Ryu EJ, Harding HP, Angelastro JM, Vitolo OV, Ron D, Greene LA. Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. J Neurosci. 2002 Dec 15; 22(24):10690-8. PMID: 12486162.
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    27. Töröcsik B, Angelastro JM, Greene LA. The basic region and leucine zipper transcription factor MafK is a new nerve growth factor-responsive immediate early gene that regulates neurite outgrowth. J Neurosci. 2002 Oct 15; 22(20):8971-80. PMID: 12388604.
      View in: PubMed
    28. Angelastro JM, Ryu EJ, Törõcsik B, Fiske BK, Greene LA. Blue-white selection step enhances the yield of SAGE concatemers. Biotechniques. 2002 Mar; 32(3):484, 486. PMID: 11911650.
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    29. Angelastro JM, Töröcsik B, Greene LA. Nerve growth factor selectively regulates expression of transcripts encoding ribosomal proteins. BMC Neurosci. 2002; 3:3. PMID: 11922865.
      View in: PubMed
    30. Troy CM, Rabacchi SA, Hohl JB, Angelastro JM, Greene LA, Shelanski ML. Death in the balance: alternative participation of the caspase-2 and -9 pathways in neuronal death induced by nerve growth factor deprivation. J Neurosci. 2001 Jul 15; 21(14):5007-16. PMID: 11438576.
      View in: PubMed
    31. Angelastro JM, Moon NY, Liu DX, Yang AS, Greene LA, Franke TF. Characterization of a novel isoform of caspase-9 that inhibits apoptosis. J Biol Chem. 2001 Apr 13; 276(15):12190-200. PMID: 11278518.
      View in: PubMed
    32. Angelastro JM, Klimaschewski L, Tang S, Vitolo OV, Weissman TA, Donlin LT, Shelanski ML, Greene LA. Identification of diverse nerve growth factor-regulated genes by serial analysis of gene expression (SAGE) profiling. Proc Natl Acad Sci U S A. 2000 Sep 12; 97(19):10424-9. PMID: 10984536.
      View in: PubMed
    33. Angelastro JM, Klimaschewski LP, Vitolo OV. Improved NlaIII digestion of PAGE-purified 102 bp ditags by addition of a single purification step in both the SAGE and microSAGE protocols. Nucleic Acids Res. 2000 Jun 15; 28(12):E62. PMID: 10871385.
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    34. Angelastro JM, Ho CL, Frappier T, Liem RK, Greene LA. Peripherin is tyrosine-phosphorylated at its carboxyl-terminal tyrosine. J Neurochem. 1998 Feb; 70(2):540-9. PMID: 9453548.
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    35. Peng X, Angelastro JM, Greene LA. Tyrosine phosphorylation of extracellular signal-regulated protein kinase 4 in response to growth factors. J Neurochem. 1996 Mar; 66(3):1191-7. PMID: 8769883.
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    36. Angelastro JM, Purich DL. Phosphorylation states of actin filament adenine nucleotides in detergent-extracted neuronal cytoskeletal fractions. Biochem Biophys Res Commun. 1994 Jun 30; 201(3):1490-4. PMID: 8024594.
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    37. Purich DL, Angelastro JM. Microtubule dynamics: bioenergetics and control. Adv Enzymol Relat Areas Mol Biol. 1994; 69:121-54. PMID: 7817867.
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    38. Volonté C, Angelastro JM, Greene LA. Association of protein kinases ERK1 and ERK2 with p75 nerve growth factor receptors. J Biol Chem. 1993 Oct 05; 268(28):21410-5. PMID: 8407983.
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    39. Angelastro JM, Purich DL. 2'-Deoxy-GTP in the microtubule cytoskeleton of neuronal cells cultured with nerve growth factor. J Biol Chem. 1992 Dec 25; 267(36):25685-9. PMID: 1464585.
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    40. Angelastro JM, Purich DL. Adenine and guanine nucleotide content of Triton-extracted cytoskeletal fractions of nonmuscle cells. Anal Biochem. 1992 Jul; 204(1):47-52. PMID: 1514695.
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    41. Eaker EY, Angelastro JM, Purich DL, Sninsky CA. Evidence against impaired brain microtubule protein polymerization at high glucose concentrations or during diabetes mellitus. J Neurochem. 1991 Jun; 56(6):2087-93. PMID: 2027016.
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    42. Angelastro JM, Purich DL. Apparently irreversible GTP hydrolysis attends tubulin self-assembly. Eur J Biochem. 1990 Jul 31; 191(2):507-11. PMID: 2384097.
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