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Kermit Carraway

TitlePROF-HCOMP
InstitutionUniversity of California Davis
DepartmentMED: BIOCHEM & MOLECULAR MED
AddressResearch III Bldg/UCDMC
CA 95817
Phone916-734-3114
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. VanderVorst K, Hatakeyama J, Berg A, Lee H, Carraway K. Cellular and molecular mechanisms underlying planar cell polarity pathway contributions to cancer malignancy. Semin Cell Dev Biol. 2017 Nov 04. PMID: 29107170.
      View in: PubMed
    2. Scharadin TM, He W, Yiannakou Y, Tomilov AA, Saldana M, Cortopassi GA, Carraway K, Coleman MA, Henderson PT. Synthesis and biochemical characterization of EGF receptor in a water-soluble membrane model system. PLoS One. 2017; 12(6):e0177761. PMID: 28586369.
      View in: PubMed
    3. Printsev I, Curiel D, Carraway K. Membrane Protein Quantity Control at the Endoplasmic Reticulum. J Membr Biol. 2017 Aug; 250(4):379-392. PMID: 27743014.
      View in: PubMed
    4. Hatakeyama J, Wald JH, Rafidi H, Cuevas A, Sweeney C, Carraway K. The ER structural protein Rtn4A stabilizes and enhances signaling through the receptor tyrosine kinase ErbB3. Sci Signal. 2016 06 28; 9(434):ra65. PMID: 27353365.
      View in: PubMed
    5. Amir S, Simion C, Umeh-Garcia M, Krig S, Moss T, Carraway K, Sweeney C. Regulation of the T-box transcription factor Tbx3 by the tumour suppressor microRNA-206 in breast cancer. Br J Cancer. 2016 05 10; 114(10):1125-34. PMID: 27100732.
      View in: PubMed
    6. Rowson-Hodel AR, Berg AL, Wald JH, Hatakeyama J, VanderVorst K, Curiel DA, Leon LJ, Sweeney C, Carraway K. Hexamethylene amiloride engages a novel reactive oxygen species- and lysosome-dependent programmed necrotic mechanism to selectively target breast cancer cells. Cancer Lett. 2016 May 28; 375(1):62-72. PMID: 26944316.
      View in: PubMed
    7. He W, Scharadin TM, Saldana M, Gellner C, Hoang-Phou S, Takanishi C, Hura GL, Tainer JA, Carraway K, Henderson PT, Coleman MA. Cell-free expression of functional receptor tyrosine kinases. Sci Rep. 2015 Aug 14; 5:12896. PMID: 26274523; PMCID: PMC4929682.
      View in: PubMed, PubMed Central
    8. Savoy RM, Chen L, Siddiqui S, Melgoza FU, Durbin-Johnson B, Drake C, Jathal MK, Bose S, Steele TM, Mooso BA, D'Abronzo LS, Fry WH, Carraway K, Mudryj M, Ghosh PM. Transcription of Nrdp1 by the androgen receptor is regulated by nuclear filamin A in prostate cancer. Endocr Relat Cancer. 2015 Jun; 22(3):369-86. PMID: 25759396; PMCID: PMC4433410.
      View in: PubMed, PubMed Central
    9. Hatakeyama J, Wald JH, Printsev I, Ho HY, Carraway K. Vangl1 and Vangl2: planar cell polarity components with a developing role in cancer. Endocr Relat Cancer. 2014 Oct; 21(5):R345-56. PMID: 24981109; PMCID: PMC4332879.
      View in: PubMed, PubMed Central
    10. Wecksler AT, Hwang SH, Wettersten HI, Gilda JE, Patton A, Leon LJ, Carraway K, Gomes AV, Baar K, Weiss RH, Hammock BD. Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB. Anticancer Drugs. 2014 Apr; 25(4):433-46. PMID: 24525589; PMCID: PMC3947856.
      View in: PubMed, PubMed Central
    11. Printsev I, Yen L, Sweeney C, Carraway K. Oligomerization of the Nrdp1 E3 ubiquitin ligase is necessary for efficient autoubiquitination but not ErbB3 ubiquitination. J Biol Chem. 2014 Mar 21; 289(12):8570-8. PMID: 24519943; PMCID: PMC3961680.
      View in: PubMed, PubMed Central
    12. Hong SY, Shih YP, Li T, Carraway K, Lo SH. CTEN prolongs signaling by EGFR through reducing its ligand-induced degradation. Cancer Res. 2013 Aug 15; 73(16):5266-76. PMID: 23774213; PMCID: PMC3745516.
      View in: PubMed, PubMed Central
    13. Rafidi H, Mercado F, Astudillo M, Fry WH, Saldana M, Carraway K, Sweeney C. Leucine-rich repeat and immunoglobulin domain-containing protein-1 (Lrig1) negative regulatory action toward ErbB receptor tyrosine kinases is opposed by leucine-rich repeat and immunoglobulin domain-containing protein 3 (Lrig3). J Biol Chem. 2013 Jul 26; 288(30):21593-605. PMID: 23723069; PMCID: PMC3724619.
      View in: PubMed, PubMed Central
    14. Leon LJ, Pasupuleti N, Gorin F, Carraway K. A cell-permeant amiloride derivative induces caspase-independent, AIF-mediated programmed necrotic death of breast cancer cells. PLoS One. 2013; 8(4):e63038. PMID: 23646172; PMCID: PMC3639988.
      View in: PubMed, PubMed Central
    15. Krig SR, Frietze S, Simion C, Miller JK, Fry WH, Rafidi H, Kotelawala L, Qi L, Griffith OL, Gray JW, Carraway K, Sweeney C. Lrig1 is an estrogen-regulated growth suppressor and correlates with longer relapse-free survival in ERa-positive breast cancer. Mol Cancer Res. 2011 Oct; 9(10):1406-17. PMID: 21821674; PMCID: PMC3196675.
      View in: PubMed, PubMed Central
    16. Albrecht H, Carraway K. MUC1 and MUC4: switching the emphasis from large to small. Cancer Biother Radiopharm. 2011 Jun; 26(3):261-71. PMID: 21728842; PMCID: PMC3128783.
      View in: PubMed, PubMed Central
    17. Fry WH, Simion C, Sweeney C, Carraway K. Quantity control of the ErbB3 receptor tyrosine kinase at the endoplasmic reticulum. Mol Cell Biol. 2011 Jul; 31(14):3009-18. PMID: 21576364; PMCID: PMC3133396.
      View in: PubMed, PubMed Central
    18. Carraway K. E3 ubiquitin ligases in ErbB receptor quantity control. Semin Cell Dev Biol. 2010 Dec; 21(9):936-43. PMID: 20868762; PMCID: PMC2991564.
      View in: PubMed, PubMed Central
    19. Kozloski GA, Carraway CA, Carraway K. Mechanistic and signaling analysis of Muc4-ErbB2 signaling module: new insights into the mechanism of ligand-independent ErbB2 activity. J Cell Physiol. 2010 Sep; 224(3):649-57. PMID: 20432461; PMCID: PMC2897936.
      View in: PubMed, PubMed Central
    20. Ingalla EQ, Miller JK, Wald JH, Workman HC, Kaur RP, Yen L, Fry WH, Borowsky AD, Young LJ, Sweeney C, Carraway K. Post-transcriptional mechanisms contribute to the suppression of the ErbB3 negative regulator protein Nrdp1 in mammary tumors. J Biol Chem. 2010 Sep 10; 285(37):28691-7. PMID: 20628057; PMCID: PMC2937896.
      View in: PubMed, PubMed Central
    21. Carraway K, Kozloski GA. Conformational changes in receptor tyrosine kinase signaling: an ErbB garden of delights. F1000 Biol Rep. 2009 Sep 28; 1:72. PMID: 20357902.
      View in: PubMed
    22. Workman HC, Sweeney C, Carraway K. The membrane mucin Muc4 inhibits apoptosis induced by multiple insults via ErbB2-dependent and ErbB2-independent mechanisms. Cancer Res. 2009 Apr 01; 69(7):2845-52. PMID: 19293191; PMCID: PMC2745945.
      View in: PubMed, PubMed Central
    23. Workman HC, Miller JK, Ingalla EQ, Kaur RP, Yamamoto DI, Beckett LA, Young LJ, Cardiff RD, Borowsky AD, Carraway KL, Sweeney C, Carraway KL. The membrane mucin MUC4 is elevated in breast tumor lymph node metastases relative to matched primary tumors and confers aggressive properties to breast cancer cells. Breast Cancer Res. 2009; 11(5):R70. PMID: 19761616; PMCID: PMC2790847.
      View in: PubMed, PubMed Central
    24. Miller JK, Shattuck DL, Ingalla EQ, Yen L, Borowsky AD, Young LJ, Cardiff RD, Carraway K, Sweeney C. Suppression of the negative regulator LRIG1 contributes to ErbB2 overexpression in breast cancer. Cancer Res. 2008 Oct 15; 68(20):8286-94. PMID: 18922900; PMCID: PMC2597648.
      View in: PubMed, PubMed Central
    25. Fry WH, Kotelawala L, Sweeney C, Carraway K. Mechanisms of ErbB receptor negative regulation and relevance in cancer. Exp Cell Res. 2009 Feb 15; 315(4):697-706. PMID: 18706412; PMCID: PMC2667444.
      View in: PubMed, PubMed Central
    26. Shattuck DL, Miller JK, Carraway K, Sweeney C. Met receptor contributes to trastuzumab resistance of Her2-overexpressing breast cancer cells. Cancer Res. 2008 Mar 01; 68(5):1471-7. PMID: 18316611.
      View in: PubMed
    27. Cao Z, Wu X, Yen L, Sweeney C, Carraway K. Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1. Mol Cell Biol. 2007 Mar; 27(6):2180-8. PMID: 17210635; PMCID: PMC1820496.
      View in: PubMed, PubMed Central
    28. Carraway K, Funes M, Workman HC, Sweeney C. Contribution of membrane mucins to tumor progression through modulation of cellular growth signaling pathways. Curr Top Dev Biol. 2007; 78:1-22. PMID: 17338913.
      View in: PubMed
    29. Shattuck DL, Miller JK, Laederich M, Funes M, Petersen H, Carraway K, Sweeney C. LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy. Mol Cell Biol. 2007 Mar; 27(5):1934-46. PMID: 17178829; PMCID: PMC1820466.
      View in: PubMed, PubMed Central
    30. Yen L, Cao Z, Wu X, Ingalla ER, Baron C, Young LJ, Gregg JP, Cardiff RD, Borowsky AD, Sweeney C, Carraway K. Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell growth. Cancer Res. 2006 Dec 01; 66(23):11279-86. PMID: 17145873.
      View in: PubMed
    31. Ballif BA, Cao Z, Schwartz D, Carraway K, Gygi SP. Identification of 14-3-3epsilon substrates from embryonic murine brain. J Proteome Res. 2006 Sep; 5(9):2372-9. PMID: 16944949.
      View in: PubMed
    32. Pino V, Ramsauer VP, Salas P, Carothers Carraway CA, Carraway K. Membrane mucin Muc4 induces density-dependent changes in ERK activation in mammary epithelial and tumor cells: role in reversal of contact inhibition. J Biol Chem. 2006 Sep 29; 281(39):29411-20. PMID: 16891313.
      View in: PubMed
    33. Carraway K, Sweeney C. Co-opted integrin signaling in ErbB2-induced mammary tumor progression. Cancer Cell. 2006 Aug; 10(2):93-5. PMID: 16904607.
      View in: PubMed
    34. Funes M, Miller JK, Lai C, Carraway K, Sweeney C. The mucin Muc4 potentiates neuregulin signaling by increasing the cell-surface populations of ErbB2 and ErbB3. J Biol Chem. 2006 Jul 14; 281(28):19310-9. PMID: 16690615.
      View in: PubMed
    35. Ramsauer VP, Pino V, Farooq A, Carothers Carraway CA, Salas PJ, Carraway K. Muc4-ErbB2 complex formation and signaling in polarized CACO-2 epithelial cells indicate that Muc4 acts as an unorthodox ligand for ErbB2. Mol Biol Cell. 2006 Jul; 17(7):2931-41. PMID: 16624867; PMCID: PMC1483030.
      View in: PubMed, PubMed Central
    36. Sweeney C, Miller JK, Shattuck DL, Carraway K. ErbB receptor negative regulatory mechanisms: implications in cancer. J Mammary Gland Biol Neoplasia. 2006 Jan; 11(1):89-99. PMID: 16865534.
      View in: PubMed
    37. Carraway K, Ramsauer VP, Carraway CA. Glycoprotein contributions to mammary gland and mammary tumor structure and function: roles of adherens junctions, ErbBs and membrane MUCs. J Cell Biochem. 2005 Dec 01; 96(5):914-26. PMID: 16167329.
      View in: PubMed
    38. Price-Schiavi SA, Andrechek E, Idris N, Li P, Rong M, Zhang J, Carothers Carraway CA, Muller WJ, Carraway K. Expression, location, and interactions of ErbB2 and its intramembrane ligand Muc4 (sialomucin complex) in rat mammary gland during pregnancy. J Cell Physiol. 2005 Apr; 203(1):44-53. PMID: 15499570.
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    39. Nagy P, Friedländer E, Tanner M, Kapanen AI, Carraway K, Isola J, Jovin TM. Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a herceptin-resistant, MUC4-expressing breast cancer cell line. Cancer Res. 2005 Jan 15; 65(2):473-82. PMID: 15695389.
      View in: PubMed
    40. Laederich MB, Funes-Duran M, Yen L, Ingalla E, Wu X, Carraway K, Sweeney C. The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases. J Biol Chem. 2004 Nov 05; 279(45):47050-6. PMID: 15345710.
      View in: PubMed
    41. Wu X, Yen L, Irwin L, Sweeney C, Carraway K. Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8. Mol Cell Biol. 2004 Sep; 24(17):7748-57. PMID: 15314180; PMCID: PMC506982.
      View in: PubMed, PubMed Central
    42. Perez A, Barco R, Fernandez I, Price-Schiavi SA, Carraway K. PEA3 transactivates the Muc4/sialomucin complex promoter in mammary epithelial and tumor cells. J Biol Chem. 2003 Sep 19; 278(38):36942-52. PMID: 12855694.
      View in: PubMed
    43. Ramsauer VP, Carraway CA, Salas PJ, Carraway K. Muc4/sialomucin complex, the intramembrane ErbB2 ligand, translocates ErbB2 to the apical surface in polarized epithelial cells. J Biol Chem. 2003 Aug 08; 278(32):30142-7. PMID: 12748185.
      View in: PubMed
    44. Dammann CE, Nielsen HC, Carraway K. Role of neuregulin-1 beta in the developing lung. Am J Respir Crit Care Med. 2003 Jun 15; 167(12):1711-6. PMID: 12663324.
      View in: PubMed
    45. Carraway K, Ramsauer VP, Haq B, Carothers Carraway CA. Cell signaling through membrane mucins. Bioessays. 2003 Jan; 25(1):66-71. PMID: 12508284.
      View in: PubMed
    46. Jepson S, Komatsu M, Haq B, Arango ME, Huang D, Carraway CA, Carraway K. Muc4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27(kip), but does not activate mitogen-activated kinase or protein kinaseB/Akt pathways. Oncogene. 2002 Oct 24; 21(49):7524-32. PMID: 12386815.
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    47. Ravid T, Sweeney C, Gee P, Carraway K, Goldkorn T. Epidermal growth factor receptor activation under oxidative stress fails to promote c-Cbl mediated down-regulation. J Biol Chem. 2002 Aug 23; 277(34):31214-9. PMID: 12063263.
      View in: PubMed
    48. Carraway K, Sweeney C. EGF receptor activation by heterologous mechanisms. Cancer Cell. 2002 Jun; 1(5):405-6. PMID: 12124166.
      View in: PubMed
    49. Swan JS, Arango ME, Carothers Carraway CA, Carraway K. An ErbB2-Muc4 complex in rat ocular surface epithelia. Curr Eye Res. 2002 May; 24(5):397-402. PMID: 12434309.
      View in: PubMed
    50. Diamonti AJ, Guy PM, Ivanof C, Wong K, Sweeney C, Carraway K. An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):2866-71. PMID: 11867753; PMCID: PMC122439.
      View in: PubMed, PubMed Central
    51. Ghiglione C, Bach EA, Paraiso Y, Carraway K, Noselli S, Perrimon N. Mechanism of activation of the Drosophila EGF Receptor by the TGFalpha ligand Gurken during oogenesis. Development. 2002 Jan; 129(1):175-86. PMID: 11782411.
      View in: PubMed
    52. Carraway K, Perez A, Idris N, Jepson S, Arango M, Komatsu M, Haq B, Price-Schiavi SA, Zhang J, Carraway CA. Muc4/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to survive. Prog Nucleic Acid Res Mol Biol. 2002; 71:149-85. PMID: 12102554.
      View in: PubMed
    53. Carraway K, Sweeney C. Localization and modulation of ErbB receptor tyrosine kinases. Curr Opin Cell Biol. 2001 Apr; 13(2):125-30. PMID: 11248544.
      View in: PubMed
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