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Kermit L Carraway

Title(s)Professor, Biochemistry and Molecular Medicine
SchoolUniversity of California, Davis
Phone916-734-3114
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Umeh-Garcia M, Simion C, Ho PY, Batra N, Berg AL, Carraway KL, Yu A, Sweeney C. A Novel Bioengineered MicroRNA-127 Prodrug Suppresses The Growth And Metastatic Potential Of Triple Negative Breast Cancer Cells. Cancer Res. 2019 Nov 06. PMID: 31694904.
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    2. VanderVorst K, Dreyer CA, Konopelski SE, Lee H, Ho HH, Carraway KL. Wnt/PCP Signaling Contribution to Carcinoma Collective Cell Migration and Metastasis. Cancer Res. 2019 04 15; 79(8):1719-1729. PMID: 30952630.
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    3. Saldana M, VanderVorst K, Berg AL, Lee H, Carraway KL. Otubain 1: a non-canonical deubiquitinase with an emerging role in cancer. Endocr Relat Cancer. 2019 01 01; 26(1):R1-R14. PMID: 30400005.
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    4. Quinn SD, Srinivasan S, Gordon JB, He W, Carraway KL, Coleman MA, Schlau-Cohen GS. Single-Molecule Fluorescence Detection of the Epidermal Growth Factor Receptor in Membrane Discs. Biochemistry. 2019 01 29; 58(4):286-294. PMID: 29553754.
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    5. VanderVorst K, Hatakeyama J, Berg A, Lee H, Carraway KL. Cellular and molecular mechanisms underlying planar cell polarity pathway contributions to cancer malignancy. Semin Cell Dev Biol. 2018 09; 81:78-87. PMID: 29107170.
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    6. Rowson-Hodel AR, Wald JH, Hatakeyama J, O'Neal WK, Stonebraker JR, VanderVorst K, Saldana MJ, Borowsky AD, Sweeney C, Carraway KL. Membrane Mucin Muc4 promotes blood cell association with tumor cells and mediates efficient metastasis in a mouse model of breast cancer. Oncogene. 2018 01 11; 37(2):197-207. PMID: 28892049.
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    7. Showalter MR, Hatakeyama J, Cajka T, VanderVorst K, Carraway KL, Fiehn O. Replication Study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Elife. 2017 06 27; 6. PMID: 28653623.
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    8. Scharadin TM, He W, Yiannakou Y, Tomilov AA, Saldana M, Cortopassi GA, Carraway KL, Coleman MA, Henderson PT. Synthesis and biochemical characterization of EGF receptor in a water-soluble membrane model system. PLoS One. 2017; 12(6):e0177761. PMID: 28586369.
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    9. Wald JH, Hatakeyama J, Printsev I, Cuevas A, Fry WHD, Saldana MJ, VanderVorst K, Rowson-Hodel A, Angelastro JM, Sweeney C, Carraway KL. Suppression of planar cell polarity signaling and migration in glioblastoma by Nrdp1-mediated Dvl polyubiquitination. Oncogene. 2017 09 07; 36(36):5158-5167. PMID: 28481871.
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    10. Printsev I, Curiel D, Carraway KL. Membrane Protein Quantity Control at the Endoplasmic Reticulum. J Membr Biol. 2017 Aug; 250(4):379-392. PMID: 27743014.
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    11. Hatakeyama J, Wald JH, Rafidi H, Cuevas A, Sweeney C, Carraway KL. The ER structural protein Rtn4A stabilizes and enhances signaling through the receptor tyrosine kinase ErbB3. Sci Signal. 2016 06 28; 9(434):ra65. PMID: 27353365.
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    12. Amir S, Simion C, Umeh-Garcia M, Krig S, Moss T, Carraway KL, Sweeney C. Regulation of the T-box transcription factor Tbx3 by the tumour suppressor microRNA-206 in breast cancer. Br J Cancer. 2016 05 10; 114(10):1125-34. PMID: 27100732.
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    13. Rowson-Hodel AR, Berg AL, Wald JH, Hatakeyama J, VanderVorst K, Curiel DA, Leon LJ, Sweeney C, Carraway KL. Hexamethylene amiloride engages a novel reactive oxygen species- and lysosome-dependent programmed necrotic mechanism to selectively target breast cancer cells. Cancer Lett. 2016 May 28; 375(1):62-72. PMID: 26944316.
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    14. Yokdang N, Hatakeyama J, Wald JH, Simion C, Tellez JD, Chang DZ, Swamynathan MM, Chen M, Murphy WJ, Carraway Iii KL, Sweeney C. LRIG1 opposes epithelial-to-mesenchymal transition and inhibits invasion of basal-like breast cancer cells. Oncogene. 2016 06 02; 35(22):2932-47. PMID: 26387542.
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    15. He W, Scharadin TM, Saldana M, Gellner C, Hoang-Phou S, Takanishi C, Hura GL, Tainer JA, Carraway KL, Henderson PT, Coleman MA. Cell-free expression of functional receptor tyrosine kinases. Sci Rep. 2015 Aug 14; 5:12896. PMID: 26274523.
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    16. Savoy RM, Chen L, Siddiqui S, Melgoza FU, Durbin-Johnson B, Drake C, Jathal MK, Bose S, Steele TM, Mooso BA, D'Abronzo LS, Fry WH, Carraway KL, Mudryj M, Ghosh PM. Transcription of Nrdp1 by the androgen receptor is regulated by nuclear filamin A in prostate cancer. Endocr Relat Cancer. 2015 Jun; 22(3):369-86. PMID: 25759396.
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    17. Hatakeyama J, Wald JH, Printsev I, Ho HY, Carraway KL. Vangl1 and Vangl2: planar cell polarity components with a developing role in cancer. Endocr Relat Cancer. 2014 Oct; 21(5):R345-56. PMID: 24981109.
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    18. Wecksler AT, Hwang SH, Wettersten HI, Gilda JE, Patton A, Leon LJ, Carraway KL, Gomes AV, Baar K, Weiss RH, Hammock BD. Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB. Anticancer Drugs. 2014 Apr; 25(4):433-46. PMID: 24525589.
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    19. Printsev I, Yen L, Sweeney C, Carraway KL. Oligomerization of the Nrdp1 E3 ubiquitin ligase is necessary for efficient autoubiquitination but not ErbB3 ubiquitination. J Biol Chem. 2014 Mar 21; 289(12):8570-8. PMID: 24519943.
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    20. Hong SY, Shih YP, Li T, Carraway KL, Lo SH. CTEN prolongs signaling by EGFR through reducing its ligand-induced degradation. Cancer Res. 2013 Aug 15; 73(16):5266-76. PMID: 23774213.
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    21. Rafidi H, Mercado F, Astudillo M, Fry WH, Saldana M, Carraway KL, Sweeney C. Leucine-rich repeat and immunoglobulin domain-containing protein-1 (Lrig1) negative regulatory action toward ErbB receptor tyrosine kinases is opposed by leucine-rich repeat and immunoglobulin domain-containing protein 3 (Lrig3). J Biol Chem. 2013 Jul 26; 288(30):21593-605. PMID: 23723069.
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    22. Leon LJ, Pasupuleti N, Gorin F, Carraway KL. A cell-permeant amiloride derivative induces caspase-independent, AIF-mediated programmed necrotic death of breast cancer cells. PLoS One. 2013; 8(4):e63038. PMID: 23646172.
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    23. Perez A, Neskey DM, Wen J, Pereira L, Reategui EP, Goodwin WJ, Carraway KL, Franzmann EJ. CD44 interacts with EGFR and promotes head and neck squamous cell carcinoma initiation and progression. Oral Oncol. 2013 Apr; 49(4):306-13. PMID: 23265944.
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    24. Pasupuleti N, Leon L, Carraway KL, Gorin F. 5-Benzylglycinyl-amiloride kills proliferating and nonproliferating malignant glioma cells through caspase-independent necroptosis mediated by apoptosis-inducing factor. J Pharmacol Exp Ther. 2013 Mar; 344(3):600-15. PMID: 23241369.
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    25. Liu W, Hsu DK, Chen HY, Yang RY, Carraway KL, Isseroff RR, Liu FT. Galectin-3 regulates intracellular trafficking of EGFR through Alix and promotes keratinocyte migration. J Invest Dermatol. 2012 Dec; 132(12):2828-37. PMID: 22785133.
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    26. Krig SR, Frietze S, Simion C, Miller JK, Fry WH, Rafidi H, Kotelawala L, Qi L, Griffith OL, Gray JW, Carraway KL, Sweeney C. Lrig1 is an estrogen-regulated growth suppressor and correlates with longer relapse-free survival in ERa-positive breast cancer. Mol Cancer Res. 2011 Oct; 9(10):1406-17. PMID: 21821674.
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    27. Albrecht H, Carraway KL. MUC1 and MUC4: switching the emphasis from large to small. Cancer Biother Radiopharm. 2011 Jun; 26(3):261-71. PMID: 21728842.
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    28. Fry WH, Simion C, Sweeney C, Carraway KL. Quantity control of the ErbB3 receptor tyrosine kinase at the endoplasmic reticulum. Mol Cell Biol. 2011 Jul; 31(14):3009-18. PMID: 21576364.
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    29. Harley W, Floyd C, Dunn T, Zhang XD, Chen TY, Hegde M, Palandoken H, Nantz MH, Leon L, Carraway KL, Lyeth B, Gorin FA. Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas. Brain Res. 2010 Dec 02; 1363:159-69. PMID: 20869350.
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    30. Carraway KL. E3 ubiquitin ligases in ErbB receptor quantity control. Semin Cell Dev Biol. 2010 Dec; 21(9):936-43. PMID: 20868762.
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    31. Kozloski GA, Carraway CA, Carraway KL. Mechanistic and signaling analysis of Muc4-ErbB2 signaling module: new insights into the mechanism of ligand-independent ErbB2 activity. J Cell Physiol. 2010 Sep; 224(3):649-57. PMID: 20432461.
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    32. Ingalla EQ, Miller JK, Wald JH, Workman HC, Kaur RP, Yen L, Fry WH, Borowsky AD, Young LJ, Sweeney C, Carraway KL. Post-transcriptional mechanisms contribute to the suppression of the ErbB3 negative regulator protein Nrdp1 in mammary tumors. J Biol Chem. 2010 Sep 10; 285(37):28691-7. PMID: 20628057.
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    33. Chen L, Siddiqui S, Bose S, Mooso B, Asuncion A, Bedolla RG, Vinall R, Tepper CG, Gandour-Edwards R, Shi X, Lu XH, Siddiqui J, Chinnaiyan AM, Mehra R, Devere White RW, Carraway KL, Ghosh PM. Nrdp1-mediated regulation of ErbB3 expression by the androgen receptor in androgen-dependent but not castrate-resistant prostate cancer cells. Cancer Res. 2010 Jul 15; 70(14):5994-6003. PMID: 20587519.
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    34. Lomako J, Lomako WM, Carothers Carraway CA, Carraway KL. Regulation of the membrane mucin Muc4 in corneal epithelial cells by proteosomal degradation and TGF-beta. J Cell Physiol. 2010 Apr; 223(1):209-14. PMID: 20054827.
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    35. Cai J, Crotty TM, Reichert E, Carraway KL, Stafforini DM, Topham MK. Diacylglycerol kinase delta and protein kinase C(alpha) modulate epidermal growth factor receptor abundance and degradation through ubiquitin-specific protease 8. J Biol Chem. 2010 Mar 05; 285(10):6952-9. PMID: 20064931.
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    36. Carraway KL, Theodoropoulos G, Kozloski GA, Carothers Carraway CA. Muc4/MUC4 functions and regulation in cancer. Future Oncol. 2009 Dec; 5(10):1631-40. PMID: 20001800.
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    37. Carraway KL, Kozloski GA. Conformational changes in receptor tyrosine kinase signaling: an ErbB garden of delights. F1000 Biol Rep. 2009 Sep 28; 1:72. PMID: 20357902.
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    38. Lomako WM, Lomako J, Soto P, Carraway CA, Carraway KL. TGFbeta regulation of membrane mucin Muc4 via proteosome degradation. J Cell Biochem. 2009 Jul 01; 107(4):797-802. PMID: 19388004.
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    39. Theodoropoulos G, Carraway CA, Carraway KL. MUC4 involvement in ErbB2/ErbB3 phosphorylation and signaling in response to airway cell mechanical injury. J Cell Biochem. 2009 May 01; 107(1):112-22. PMID: 19288496.
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    40. Workman HC, Sweeney C, Carraway KL. The membrane mucin Muc4 inhibits apoptosis induced by multiple insults via ErbB2-dependent and ErbB2-independent mechanisms. Cancer Res. 2009 Apr 01; 69(7):2845-52. PMID: 19293191.
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    41. Workman HC, Miller JK, Ingalla EQ, Kaur RP, Yamamoto DI, Beckett LA, Young LJ, Cardiff RD, Borowsky AD, Carraway KL, Sweeney C, Carraway KL. The membrane mucin MUC4 is elevated in breast tumor lymph node metastases relative to matched primary tumors and confers aggressive properties to breast cancer cells. Breast Cancer Res. 2009; 11(5):R70. PMID: 19761616.
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    42. Miller JK, Shattuck DL, Ingalla EQ, Yen L, Borowsky AD, Young LJ, Cardiff RD, Carraway KL, Sweeney C. Suppression of the negative regulator LRIG1 contributes to ErbB2 overexpression in breast cancer. Cancer Res. 2008 Oct 15; 68(20):8286-94. PMID: 18922900.
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    43. Fry WH, Kotelawala L, Sweeney C, Carraway KL. Mechanisms of ErbB receptor negative regulation and relevance in cancer. Exp Cell Res. 2009 Feb 15; 315(4):697-706. PMID: 18706412.
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    44. Stutz MA, Shattuck DL, Laederich MB, Carraway KL, Sweeney C. LRIG1 negatively regulates the oncogenic EGF receptor mutant EGFRvIII. Oncogene. 2008 Sep 25; 27(43):5741-52. PMID: 18542056.
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    45. Miyahara N, Shoda J, Ishige K, Kawamoto T, Ueda T, Taki R, Ohkohchi N, Hyodo I, Thomas MB, Krishnamurthy S, Carraway KL, Irimura T. MUC4 interacts with ErbB2 in human gallbladder carcinoma: potential pathobiological implications. Eur J Cancer. 2008 May; 44(7):1048-56. PMID: 18397823.
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    46. Shattuck DL, Miller JK, Carraway KL, Sweeney C. Met receptor contributes to trastuzumab resistance of Her2-overexpressing breast cancer cells. Cancer Res. 2008 Mar 01; 68(5):1471-7. PMID: 18316611.
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    47. Theodoropoulos G, Carraway KL. Molecular signaling in the regulation of mucins. J Cell Biochem. 2007 Dec 01; 102(5):1103-16. PMID: 17957706.
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    48. Jonckheere N, Vincent A, Perrais M, Ducourouble MP, Male AK, Aubert JP, Pigny P, Carraway KL, Freund JN, Renes IB, Van Seuningen I. The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells. J Biol Chem. 2007 Aug 03; 282(31):22638-50. PMID: 17553805.
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    49. Carraway CA, Carraway KL. Sequestration and segregation of receptor kinases in epithelial cells: implications for ErbB2 oncogenesis. Sci STKE. 2007 Apr 10; 2007(381):re3. PMID: 17426346.
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    50. Cao Z, Wu X, Yen L, Sweeney C, Carraway KL. Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1. Mol Cell Biol. 2007 Mar; 27(6):2180-8. PMID: 17210635.
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    51. Carraway KL, Funes M, Workman HC, Sweeney C. Contribution of membrane mucins to tumor progression through modulation of cellular growth signaling pathways. Curr Top Dev Biol. 2007; 78:1-22. PMID: 17338913.
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    52. Shattuck DL, Miller JK, Laederich M, Funes M, Petersen H, Carraway KL, Sweeney C. LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy. Mol Cell Biol. 2007 Mar; 27(5):1934-46. PMID: 17178829.
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    53. Yen L, Cao Z, Wu X, Ingalla ER, Baron C, Young LJ, Gregg JP, Cardiff RD, Borowsky AD, Sweeney C, Carraway KL. Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell growth. Cancer Res. 2006 Dec 01; 66(23):11279-86. PMID: 17145873.
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    54. Zhang J, Carraway CA, Carraway KL. Muc4 expression during blood vessel formation in damaged rat cornea. Curr Eye Res. 2006 Dec; 31(12):1011-4. PMID: 17169838.
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    55. Reategui EP, de Mayolo AA, Das PM, Astor FC, Singal R, Hamilton KL, Goodwin WJ, Carraway KL, Franzmann EJ. Characterization of CD44v3-containing isoforms in head and neck cancer. Cancer Biol Ther. 2006 Sep; 5(9):1163-8. PMID: 16855392.
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    56. Ballif BA, Cao Z, Schwartz D, Carraway KL, Gygi SP. Identification of 14-3-3epsilon substrates from embryonic murine brain. J Proteome Res. 2006 Sep; 5(9):2372-9. PMID: 16944949.
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    57. Zhang J, Yasin M, Carraway CA, Carraway KL. MUC4 expression and localization in gastrointestinal tract and skin of human embryos. Tissue Cell. 2006 Aug; 38(4):271-5. PMID: 16914178.
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    58. Pino V, Ramsauer VP, Salas P, Carothers Carraway CA, Carraway KL. Membrane mucin Muc4 induces density-dependent changes in ERK activation in mammary epithelial and tumor cells: role in reversal of contact inhibition. J Biol Chem. 2006 Sep 29; 281(39):29411-20. PMID: 16891313.
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    59. Carraway KL, Sweeney C. Co-opted integrin signaling in ErbB2-induced mammary tumor progression. Cancer Cell. 2006 Aug; 10(2):93-5. PMID: 16904607.
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    60. Funes M, Miller JK, Lai C, Carraway KL, Sweeney C. The mucin Muc4 potentiates neuregulin signaling by increasing the cell-surface populations of ErbB2 and ErbB3. J Biol Chem. 2006 Jul 14; 281(28):19310-9. PMID: 16690615.
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    61. Ramsauer VP, Pino V, Farooq A, Carothers Carraway CA, Salas PJ, Carraway KL. Muc4-ErbB2 complex formation and signaling in polarized CACO-2 epithelial cells indicate that Muc4 acts as an unorthodox ligand for ErbB2. Mol Biol Cell. 2006 Jul; 17(7):2931-41. PMID: 16624867.
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    62. Soto P, Zhang J, Carraway KL. Enzymatic cleavage as a processing step in the maturation of Muc4/sialomucin complex. J Cell Biochem. 2006 Apr 15; 97(6):1267-74. PMID: 16329125.
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    63. Sweeney C, Miller JK, Shattuck DL, Carraway KL. ErbB receptor negative regulatory mechanisms: implications in cancer. J Mammary Gland Biol Neoplasia. 2006 Jan; 11(1):89-99. PMID: 16865534.
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    64. Carraway KL, Ramsauer VP, Carraway CA. Glycoprotein contributions to mammary gland and mammary tumor structure and function: roles of adherens junctions, ErbBs and membrane MUCs. J Cell Biochem. 2005 Dec 01; 96(5):914-26. PMID: 16167329.
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    65. Zhang J, Perez A, Yasin M, Soto P, Rong M, Theodoropoulos G, Carothers Carraway CA, Carraway KL. Presence of MUC4 in human milk and at the luminal surfaces of blood vessels. J Cell Physiol. 2005 Jul; 204(1):166-77. PMID: 15672420.
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    66. Price-Schiavi SA, Andrechek E, Idris N, Li P, Rong M, Zhang J, Carothers Carraway CA, Muller WJ, Carraway KL. Expression, location, and interactions of ErbB2 and its intramembrane ligand Muc4 (sialomucin complex) in rat mammary gland during pregnancy. J Cell Physiol. 2005 Apr; 203(1):44-53. PMID: 15499570.
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    67. Franzmann EJ, Reategui EP, Carraway KL, Hamilton KL, Weed DT, Goodwin WJ. Salivary soluble CD44: a potential molecular marker for head and neck cancer. Cancer Epidemiol Biomarkers Prev. 2005 Mar; 14(3):735-9. PMID: 15767360.
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    68. Nagy P, Friedländer E, Tanner M, Kapanen AI, Carraway KL, Isola J, Jovin TM. Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a herceptin-resistant, MUC4-expressing breast cancer cell line. Cancer Res. 2005 Jan 15; 65(2):473-82. PMID: 15695389.
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    69. Rong M, Rossi EA, Zhang J, McNeer RR, van den Brande JM, Yasin M, Weed DT, Carothers Carraway CA, Thompson JF, Carraway KL. Expression and localization of Muc4/sialomucin complex (SMC) in the adult and developing rat intestine: implications for Muc4/SMC function. J Cell Physiol. 2005 Jan; 202(1):275-84. PMID: 15389518.
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    70. Lomako J, Lomako WM, Decker SJ, Carraway CA, Carraway KL. Non-apoptotic desquamation of cells from corneal epithelium: putative role for Muc4/sialomucin complex in cell release and survival. J Cell Physiol. 2005 Jan; 202(1):115-24. PMID: 15389535.
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    71. Wu X, Yen L, Irwin L, Sweeney C, Carraway KL. Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8. Mol Cell Biol. 2004 Sep; 24(17):7748-57. PMID: 15314180.
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    72. Laederich MB, Funes-Duran M, Yen L, Ingalla E, Wu X, Carraway KL, Sweeney C. The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases. J Biol Chem. 2004 Nov 05; 279(45):47050-6. PMID: 15345710.
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    73. Weed DT, Gomez-Fernandez C, Yasin M, Hamilton-Nelson K, Rodriguez M, Zhang J, Carraway KL. MUC4 and ErbB2 expression in squamous cell carcinoma of the upper aerodigestive tract: correlation with clinical outcomes. Laryngoscope. 2004 Aug; 114(8 Pt 2 Suppl 101):1-32. PMID: 15284539.
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    74. Weed DT, Gomez-Fernandez C, Pacheco J, Ruiz J, Hamilton-Nelson K, Arnold DJ, Civantos FJ, Zhang J, Yasin M, Goodwin WJ, Carraway KL. MUC4 and ERBB2 expression in major and minor salivary gland mucoepidermoid carcinoma. Head Neck. 2004 Apr; 26(4):353-64. PMID: 15054739.
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    75. Sweeney C, Carraway KL. Negative regulation of ErbB family receptor tyrosine kinases. Br J Cancer. 2004 Jan 26; 90(2):289-93. PMID: 14735165.
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    76. Ghiglione C, Amundadottir L, Andresdottir M, Bilder D, Diamonti JA, Noselli S, Perrimon N, Carraway III KL. Mechanism of inhibition of the Drosophila and mammalian EGF receptors by the transmembrane protein Kekkon 1. Development. 2003 Sep; 130(18):4483-93. PMID: 12900463.
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    77. Perez A, Barco R, Fernandez I, Price-Schiavi SA, Carraway KL. PEA3 transactivates the Muc4/sialomucin complex promoter in mammary epithelial and tumor cells. J Biol Chem. 2003 Sep 19; 278(38):36942-52. PMID: 12855694.
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    78. Ramsauer VP, Carraway CA, Salas PJ, Carraway KL. Muc4/sialomucin complex, the intramembrane ErbB2 ligand, translocates ErbB2 to the apical surface in polarized epithelial cells. J Biol Chem. 2003 Aug 08; 278(32):30142-7. PMID: 12748185.
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    79. Hu YP, Haq B, Carraway KL, Savaraj N, Lampidis TJ. Multidrug resistance correlates with overexpression of Muc4 but inversely with P-glycoprotein and multidrug resistance related protein in transfected human melanoma cells. Biochem Pharmacol. 2003 May 01; 65(9):1419-25. PMID: 12732353.
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    80. Soto P, Price-Schiavi SA, Carraway KL. SMAD2 and SMAD7 involvement in the post-translational regulation of Muc4 via the transforming growth factor-beta and interferon-gamma pathways in rat mammary epithelial cells. J Biol Chem. 2003 May 30; 278(22):20338-44. PMID: 12668667.
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    81. Dammann CE, Nielsen HC, Carraway KL. Role of neuregulin-1 beta in the developing lung. Am J Respir Crit Care Med. 2003 Jun 15; 167(12):1711-6. PMID: 12663324.
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    82. Carraway KL, Ramsauer VP, Haq B, Carothers Carraway CA. Cell signaling through membrane mucins. Bioessays. 2003 Jan; 25(1):66-71. PMID: 12508284.
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    83. Fischer BM, Cuellar JG, Diehl ML, deFreytas AM, Zhang J, Carraway KL, Voynow JA. Neutrophil elastase increases MUC4 expression in normal human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2003 Apr; 284(4):L671-9. PMID: 12495942.
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    84. Komatsu M, Arango ME, Carraway KL. Synthesis and secretion of Muc4/sialomucin complex: implication of intracellular proteolysis. Biochem J. 2002 Nov 15; 368(Pt 1):41-8. PMID: 12186632.
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    85. Jepson S, Komatsu M, Haq B, Arango ME, Huang D, Carraway CA, Carraway KL. Muc4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27(kip), but does not activate mitogen-activated kinase or protein kinaseB/Akt pathways. Oncogene. 2002 Oct 24; 21(49):7524-32. PMID: 12386815.
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    86. Price-Schiavi SA, Jepson S, Li P, Arango M, Rudland PS, Yee L, Carraway KL. Rat Muc4 (sialomucin complex) reduces binding of anti-ErbB2 antibodies to tumor cell surfaces, a potential mechanism for herceptin resistance. Int J Cancer. 2002 Jun 20; 99(6):783-91. PMID: 12115478.
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    87. Ravid T, Sweeney C, Gee P, Carraway KL, Goldkorn T. Epidermal growth factor receptor activation under oxidative stress fails to promote c-Cbl mediated down-regulation. J Biol Chem. 2002 Aug 23; 277(34):31214-9. PMID: 12063263.
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    88. Carraway KL, Sweeney C. EGF receptor activation by heterologous mechanisms. Cancer Cell. 2002 Jun; 1(5):405-6. PMID: 12124166.
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    89. Swan JS, Arango ME, Carothers Carraway CA, Carraway KL. An ErbB2-Muc4 complex in rat ocular surface epithelia. Curr Eye Res. 2002 May; 24(5):397-402. PMID: 12434309.
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    90. Diamonti AJ, Guy PM, Ivanof C, Wong K, Sweeney C, Carraway KL. An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):2866-71. PMID: 11867753.
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    91. Zhang J, Carraway KL. A New Monoclonal Antibody Demonstrates That Muc4, the Intramembrane Ligand for Erbb2/Her2/Neu, Is Overexpressed in Multiple Carcinomas. ScientificWorldJournal. 2002; 2:140-141. PMID: 29973843.
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    92. Carraway KL, Perez A, Idris N, Jepson S, Arango M, Komatsu M, Haq B, Price-Schiavi SA, Zhang J, Carraway CA. Muc4/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to survive. Prog Nucleic Acid Res Mol Biol. 2002; 71:149-85. PMID: 12102554.
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    93. Ghiglione C, Bach EA, Paraiso Y, Carraway KL, Noselli S, Perrimon N. Mechanism of activation of the Drosophila EGF Receptor by the TGFalpha ligand Gurken during oogenesis. Development. 2002 Jan; 129(1):175-86. PMID: 11782411.
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    94. Carraway KL, Carvajal ME, Li P, Carraway CA. ErbB2 and its ligand Muc4 (sialomucin complex) in rat lacrimal gland. Adv Exp Med Biol. 2002; 506(Pt A):289-95. PMID: 12613922.
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    95. Carraway CC, Komatsu M, Jepson S, Arango M, Carraway K. Muc4\sialomucin Complex, A Specific Intramembrane Modulator of ERBB2/HER2/NEU, Potentiates Primary Tumor Growth and Suppresses Apoptosis in A Xenotransplanted Melanoma. ScientificWorldJournal. 2001; 1:149. PMID: 30147626.
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    96. Li Y, Ren J, Yu W, Li Q, Kuwahara H, Yin L, Carraway KL, Kufe D. The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin. J Biol Chem. 2001 Sep 21; 276(38):35239-42. PMID: 11483589.
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    97. Sweeney C, Fambrough D, Huard C, Diamonti AJ, Lander ES, Cantley LC, Carraway KL. Growth factor-specific signaling pathway stimulation and gene expression mediated by ErbB receptors. J Biol Chem. 2001 Jun 22; 276(25):22685-98. PMID: 11297548.
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    98. Carraway KL, Sweeney C. Localization and modulation of ErbB receptor tyrosine kinases. Curr Opin Cell Biol. 2001 Apr; 13(2):125-30. PMID: 11248544.
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    99. Sweeney C, Carraway KL. Ligand discrimination by ErbB receptors: differential signaling through differential phosphorylation site usage. Oncogene. 2000 Nov 20; 19(49):5568-73. PMID: 11114736.
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    100. Jan AY, Johnson EF, Diamonti AJ, Carraway III KL, Anderson KS. Insights into the HER-2 receptor tyrosine kinase mechanism and substrate specificity using a transient kinetic analysis. Biochemistry. 2000 Aug 15; 39(32):9786-803. PMID: 10933796.
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    101. Sweeney C, Lai C, Riese DJ, Diamonti AJ, Cantley LC, Carraway KL. Ligand discrimination in signaling through an ErbB4 receptor homodimer. J Biol Chem. 2000 Jun 30; 275(26):19803-7. PMID: 10867024.
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    102. Ghiglione C, Carraway KL, Amundadottir LT, Boswell RE, Perrimon N, Duffy JB. The transmembrane molecule kekkon 1 acts in a feedback loop to negatively regulate the activity of the Drosophila EGF receptor during oogenesis. Cell. 1999 Mar 19; 96(6):847-56. PMID: 10102272.
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    103. Carraway KL, Rossi EA, Komatsu M, Price-Schiavi SA, Huang D, Guy PM, Carvajal ME, Fregien N, Carraway CA, Carraway KL. An intramembrane modulator of the ErbB2 receptor tyrosine kinase that potentiates neuregulin signaling. J Biol Chem. 1999 Feb 26; 274(9):5263-6. PMID: 10026131.
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    104. Crovello CS, Lai C, Cantley LC, Carraway KL. Differential signaling by the epidermal growth factor-like growth factors neuregulin-1 and neuregulin-2. J Biol Chem. 1998 Oct 09; 273(41):26954-61. PMID: 9756944.
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    105. McNeer RR, Price-Schiavi SA, Komatsu M, Fregien N, Carraway CAC, Carraway KL. Sialomucin complex in tumors and tissues. Front Biosci. 1997 09 01; 2:d449-459. PMID: 28481206.
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    106. Rameh LE, Arvidsson Ak, Carraway KL, Couvillon AD, Rathbun G, Crompton A, VanRenterghem B, Czech MP, Ravichandran KS, Burakoff SJ, Wang DS, Chen CS, Cantley LC. A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains. J Biol Chem. 1997 Aug 29; 272(35):22059-66. PMID: 9268346.
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    107. Carraway KL, Weber JL, Unger MJ, Ledesma J, Yu N, Gassmann M, Lai C. Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. Nature. 1997 May 29; 387(6632):512-6. PMID: 9168115.
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    108. Vikkula M, Boon LM, Carraway KL, Calvert JT, Diamonti AJ, Goumnerov B, Pasyk KA, Marchuk DA, Warman ML, Cantley LC, Mulliken JB, Olsen BR. Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. Cell. 1996 Dec 27; 87(7):1181-90. PMID: 8980225.
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    109. Carraway KL. Involvement of the neuregulins and their receptors in cardiac and neural development. Bioessays. 1996 Apr; 18(4):263-6. PMID: 8967893.
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    110. Carraway KL, Burden SJ. Neuregulins and their receptors. Curr Opin Neurobiol. 1995 Oct; 5(5):606-12. PMID: 8580712.
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    111. Carraway KL, Soltoff SP, Diamonti AJ, Cantley LC. Heregulin stimulates mitogenesis and phosphatidylinositol 3-kinase in mouse fibroblasts transfected with erbB2/neu and erbB3. J Biol Chem. 1995 Mar 31; 270(13):7111-6. PMID: 7535767.
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    112. Songyang Z, Carraway KL, Eck MJ, Harrison SC, Feldman RA, Mohammadi M, Schlessinger J, Hubbard SR, Smith DP, Eng C. Catalytic specificity of protein-tyrosine kinases is critical for selective signalling. Nature. 1995 Feb 09; 373(6514):536-9. PMID: 7845468.
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    113. Guy PM, Platko JV, Cantley LC, Cerione RA, Carraway KL. Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity. Proc Natl Acad Sci U S A. 1994 Aug 16; 91(17):8132-6. PMID: 8058768.
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    114. Carraway KL, Cantley LC. A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling. Cell. 1994 Jul 15; 78(1):5-8. PMID: 8033211.
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    115. Soltoff SP, Carraway KL, Prigent SA, Gullick WG, Cantley LC. ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor. Mol Cell Biol. 1994 Jun; 14(6):3550-8. PMID: 7515147.
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    116. Sliwkowski MX, Schaefer G, Akita RW, Lofgren JA, Fitzpatrick VD, Nuijens A, Fendly BM, Cerione RA, Vandlen RL, Carraway KL. Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin. J Biol Chem. 1994 May 20; 269(20):14661-5. PMID: 7514177.
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    117. Carraway KL, Sliwkowski MX, Akita R, Platko JV, Guy PM, Nuijens A, Diamonti AJ, Vandlen RL, Cantley LC, Cerione RA. The erbB3 gene product is a receptor for heregulin. J Biol Chem. 1994 May 13; 269(19):14303-6. PMID: 8188716.
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    118. Carraway KL, Cerione RA. Fluorescent-labeled growth factor molecules serve as probes for receptor binding and endocytosis. Biochemistry. 1993 Nov 16; 32(45):12039-45. PMID: 8218281.
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    119. Carraway KL, Cerione RA. Inhibition of epidermal growth factor receptor aggregation by an antibody directed against the epidermal growth factor receptor extracellular domain. J Biol Chem. 1993 Nov 15; 268(32):23860-7. PMID: 8226925.
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    120. Carraway KL, Fregien N, Carraway KL, Carraway CA. Tumor sialomucin complexes as tumor antigens and modulators of cellular interactions and proliferation. J Cell Sci. 1992 Oct; 103 ( Pt 2):299-307. PMID: 1478934.
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    121. Guy PM, Carraway KL, Cerione RA. Biochemical comparisons of the normal and oncogenic forms of insect cell-expressed neu tyrosine kinases. J Biol Chem. 1992 Jul 15; 267(20):13851-6. PMID: 1352772.
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    122. Carraway KL, Cerione RA. Comparison of epidermal growth factor (EGF) receptor-receptor interactions in intact A431 cells and isolated plasma membranes. Large scale receptor micro-aggregation is not detected during EGF-stimulated early events. J Biol Chem. 1991 May 15; 266(14):8899-906. PMID: 2026602.
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    123. Carraway KL, Koland JG, Cerione RA. Location of the epidermal growth factor binding site on the EGF receptor. A resonance energy transfer study. Biochemistry. 1990 Sep 18; 29(37):8741-7. PMID: 2271554.
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    124. Carraway KL, Koland JG, Cerione RA. Visualization of epidermal growth factor (EGF) receptor aggregation in plasma membranes by fluorescence resonance energy transfer. Correlation of receptor activation with aggregation. J Biol Chem. 1989 May 25; 264(15):8699-707. PMID: 2498317.
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    125. Wei Q, Jackson AE, Pervaiz S, Carraway KL, Lee EY, Puett D, Brew K. Effects of interaction with calcineurin on the reactivities of calmodulin lysines. J Biol Chem. 1988 Dec 25; 263(36):19541-4. PMID: 2848832.
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    126. Sanyal G, Richard LM, Carraway KL, Puett D. Binding of amphiphilic peptides to a carboxy-terminal tryptic fragment of calmodulin. Biochemistry. 1988 Aug 23; 27(17):6229-36. PMID: 3219335.
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    127. Carraway KL, Liu Y, Puett D, Carraway KL, Carraway CA. Phenothiazine binding by a homolog of calpactin, the pp60src tyrosine kinase substrate. FASEB J. 1987 Jul; 1(1):46-50. PMID: 3301497.
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    128. Jackson AE, Carraway KL, Payne ME, Means AR, Puett D, Brew K. Association of calmodulin and smooth muscle myosin light chain kinase: application of a label selection technique with trace acetylated calmodulin. Proteins. 1987; 2(3):202-9. PMID: 3128785.
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    129. Jackson AE, Carraway KL, Puett D, Brew K. Effects of the binding of myosin light chain kinase on the reactivities of calmodulin lysines. J Biol Chem. 1986 Sep 15; 261(26):12226-32. PMID: 3091599.
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