Tzipi Goldkorn

Title(s)Professor Emeritus, Pulmonary, Critical Care, and Sleep Medicine
SchoolSchool of Medicine
AddressGBSF
CA 95616
Phone530-752-2988
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    Collapse Research 
    Collapse Research Activities and Funding
    Proteasome-ErB1 Impaired Interaction in Lung Hyperplasia
    NIH R01HL071871Aug 1, 2003 - May 31, 2008
    Role: Principal Investigator
    Molecular Characteriszation of a Novel Lung Sphingomyelinase
    NIH R01HL066189Jul 1, 2001 - Nov 30, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A Tribute to John Mendelsohn: A Pioneer in Targeted Cancer Therapy. Cancer Res. 2019 09 01; 79(17):4315-4323. Kumar R, de Vijver MV, Tortora G, Ciardiello F, Goldkorn T, Miller WH, Norton L. PMID: 31213466.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    2. Farnesyltransferase Inhibition Exacerbates Eosinophilic Inflammation and Airway Hyperreactivity in Mice with Experimental Asthma: The Complex Roles of Ras GTPase and Farnesylpyrophosphate in Type 2 Allergic Inflammation. J Immunol. 2018 06 01; 200(11):3840-3856. Bratt JM, Chang KY, Rabowsky M, Franzi LM, Ott SP, Filosto S, Goldkorn T, Arif M, Last JA, Kenyon NJ, Zeki AA. PMID: 29703864; PMCID: PMC5964018.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    3. Src regulates cigarette smoke-induced ceramide generation via neutral sphingomyelinase 2 in the airway epithelium. Am J Respir Cell Mol Biol. 2015 Jun; 52(6):738-48. Chung S, Vu S, Filosto S, Goldkorn T. PMID: 25347576; PMCID: PMC4491128.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    4. Lung injury and lung cancer caused by cigarette smoke-induced oxidative stress: Molecular mechanisms and therapeutic opportunities involving the ceramide-generating machinery and epidermal growth factor receptor. Antioxid Redox Signal. 2014 Nov 20; 21(15):2149-74. Goldkorn T, Filosto S, Chung S. PMID: 24684526; PMCID: PMC4215561.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    5. Src mediates cigarette smoke-induced resistance to tyrosine kinase inhibitors in NSCLC cells. Mol Cancer Ther. 2013 Aug; 12(8):1579-90. Filosto S, Baston DS, Chung S, Becker CR, Goldkorn T. PMID: 23686837; PMCID: PMC4370317.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    6. Lung cancer and lung injury: the dual role of ceramide. Handb Exp Pharmacol. 2013; (216):93-113. Goldkorn T, Chung S, Filosto S. PMID: 23563653; PMCID: PMC4370279.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    7. Stress-Driven Endocytosis of Tyrosine-Phosphorylated EGFR Leads to Tumorigenesis: The Critical Role of Oxidative Stress. . 2013 Jan 1; 303-325. Goldkorn GT, Filosto FS, Chung CS. .
      View in: Publisher Site   Mentions:
    8. Simvastatin inhibits smoke-induced airway epithelial injury: implications for COPD therapy. Eur Respir J. 2013 Aug; 42(2):350-61. Davis BB, Zeki AA, Bratt JM, Wang L, Filosto S, Walby WF, Kenyon NJ, Goldkorn T, Schelegle ES, Pinkerton KE. PMID: 23180589; PMCID: PMC6082623.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    9. Ceramide mediates nanovesicle shedding and cell death in response to phosphatidylinositol ether lipid analogs and perifosine. Cell Death Dis. 2012 Jul 05; 3:e340. Gills JJ, Zhang C, Abu-Asab MS, Castillo SS, Marceau C, LoPiccolo J, Kozikowski AP, Tsokos M, Goldkorn T, Dennis PA. PMID: 22764099; PMCID: PMC3406576.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    10. Cigarette smoke induces aberrant EGF receptor activation that mediates lung cancer development and resistance to tyrosine kinase inhibitors. Mol Cancer Ther. 2012 Apr; 11(4):795-804. Filosto S, Becker CR, Goldkorn T. PMID: 22302097; PMCID: PMC4370319.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    11. Neutral sphingomyelinase 2 activity and protein stability are modulated by phosphorylation of five conserved serines. J Biol Chem. 2012 Jan 02; 287(1):514-522. Filosto S, Ashfaq M, Chung S, Fry W, Goldkorn T. PMID: 22074919; PMCID: PMC3249105.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    12. EGF receptor exposed to oxidative stress acquires abnormal phosphorylation and aberrant activated conformation that impairs canonical dimerization. PLoS One. 2011; 6(8):e23240. Filosto S, Khan EM, Tognon E, Becker C, Ashfaq M, Ravid T, Goldkorn T. PMID: 21853092; PMCID: PMC3154401.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    13. Statin drugs, metabolic pathways, and asthma: a therapeutic opportunity needing further research. Drug Metab Lett. 2011 Jan; 5(1):40-4. Zeki AA, Kenyon NJ, Goldkorn T. PMID: 21198438; PMCID: PMC6082624.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    14. Lung injury and cancer: Mechanistic insights into ceramide and EGFR signaling under cigarette smoke. Am J Respir Cell Mol Biol. 2010 Sep; 43(3):259-68. Goldkorn T, Filosto S. PMID: 20525802; PMCID: PMC2933544.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    15. Neutral sphingomyelinase 2: a novel target in cigarette smoke-induced apoptosis and lung injury. Am J Respir Cell Mol Biol. 2011 Mar; 44(3):350-60. Filosto S, Castillo S, Danielson A, Franzi L, Khan E, Kenyon N, Last J, Pinkerton K, Tuder R, Goldkorn T. PMID: 20448054; PMCID: PMC3095936.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimals
    16. Neutral sphingomyelinase 2 (nSMase2) is a phosphoprotein regulated by calcineurin (PP2B). J Biol Chem. 2010 Apr 02; 285(14):10213-22. Filosto S, Fry W, Knowlton AA, Goldkorn T. PMID: 20106976; PMCID: PMC2856226.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    17. Cigarette smoke exposure causes changes in Scavenger Receptor B1 level and distribution in lung cells. Int J Biochem Cell Biol. 2011 Jul; 43(7):1065-70. Valacchi G, Davis PA, Khan EM, Lanir R, Maioli E, Pecorelli A, Cross CE, Goldkorn T. PMID: 19497383.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    18. Neutral sphingomyelinase 2 is activated by cigarette smoke to augment ceramide-induced apoptosis in lung cell death. Am J Physiol Lung Cell Mol Physiol. 2009 Jul; 297(1):L125-33. Levy M, Khan E, Careaga M, Goldkorn T. PMID: 19395669; PMCID: PMC2711801.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    19. Response to: “Regarding detection of hydrogen peroxide in cigarette smoke”. The FASEB Journal. 2008 Nov 1; 22(11):3755-3756. Khan KE, Goldkorn GT. .
      View in: Publisher Site   Mentions:
    20. Monte Carlo simulation of cell death signaling predicts large cell-to-cell stochastic fluctuations through the type 2 pathway of apoptosis. Biophys J. 2008 Oct; 95(8):3559-62. Raychaudhuri S, Willgohs E, Nguyen TN, Khan EM, Goldkorn T. PMID: 18641073; PMCID: PMC2553141.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    21. Dual Roles of Oxidative Stress in the Lungs. . 2008 Jan 1; 231-250. Goldkorn GT, Khan KE. .
      View in: Publisher Site   Mentions:
    22. Epidermal growth factor receptor exposed to cigarette smoke is aberrantly activated and undergoes perinuclear trafficking. FASEB J. 2008 Mar; 22(3):910-7. Khan EM, Lanir R, Danielson AR, Goldkorn T. PMID: 17971399; PMCID: PMC4370285.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    23. Reactive nitrogen and oxygen species activate different sphingomyelinases to induce apoptosis in airway epithelial cells. Exp Cell Res. 2007 Jul 15; 313(12):2680-6. Castillo SS, Levy M, Thaikoottathil JV, Goldkorn T. PMID: 17498692.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    24. Nitric oxide-enhanced caspase-3 and acidic sphingomyelinase interaction: a novel mechanism by which airway epithelial cells escape ceramide-induced apoptosis. Exp Cell Res. 2007 Feb 15; 313(4):816-23. Castillo SS, Levy M, Wang C, Thaikoottathil JV, Khan E, Goldkorn T. PMID: 17239851.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    25. nSMase2 activation and trafficking are modulated by oxidative stress to induce apoptosis. Biochem Biophys Res Commun. 2006 Jun 09; 344(3):900-5. Levy M, Castillo SS, Goldkorn T. PMID: 16631623; PMCID: PMC4370275.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    26. Epidermal growth factor receptor exposed to oxidative stress undergoes Src- and caveolin-1-dependent perinuclear trafficking. J Biol Chem. 2006 May 19; 281(20):14486-93. Khan EM, Heidinger JM, Levy M, Lisanti MP, Ravid T, Goldkorn T. PMID: 16407214.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    27. Laser induces apoptosis and ceramide production in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2005 Jul; 46(7):2587-91. Barak A, Goldkorn T, Morse LS. PMID: 15980252.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    28. Tumor necrosis factor-{alpha} decreases Akt protein levels in 3T3-L1 adipocytes via the caspase-dependent ubiquitination of Akt. Endocrinology. 2005 Jun; 146(6):2726-35. Medina EA, Afsari RR, Ravid T, Castillo SS, Erickson KL, Goldkorn T. PMID: 15746249.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    29. Life and death decisions: ceramide generation and EGF receptor trafficking are modulated by oxidative stress. Antioxid Redox Signal. 2005 Jan-Feb; 7(1-2):119-28. Goldkorn T, Ravid T, Khan EM. PMID: 15650401.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    30. c-Cbl-mediated ubiquitinylation is required for epidermal growth factor receptor exit from the early endosomes. J Biol Chem. 2004 Aug 27; 279(35):37153-62. Ravid T, Heidinger JM, Gee P, Khan EM, Goldkorn T. PMID: 15210722.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    31. Ceramide accumulation precedes caspase-3 activation during apoptosis of A549 human lung adenocarcinoma cells. Am J Physiol Lung Cell Mol Physiol. 2003 Jun; 284(6):L1082-92. Ravid T, Tsaba A, Gee P, Rasooly R, Medina EA, Goldkorn T. PMID: 12576296; PMCID: PMC4370276.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    32. Cellular actions of Al at low (1.25 microM) concentrations in primary oligodendrocyte culture. Brain Res. 2002 Jun 21; 941(1-2):82-90. Golub MS, Zhang W, Keen CL, Goldkorn T. PMID: 12031550.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    33. Epidermal growth factor receptor activation under oxidative stress fails to promote c-Cbl mediated down-regulation. J Biol Chem. 2002 Aug 23; 277(34):31214-9. Ravid T, Sweeney C, Gee P, Carraway KL, Goldkorn T. PMID: 12063263.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    34. Ceramide-mediated apoptosis in lung epithelial cells is regulated by glutathione. Am J Respir Cell Mol Biol. 2001 Dec; 25(6):676-84. Lavrentiadou SN, Chan C, Kawcak T, Ravid T, Tsaba A, van der Vliet A, Rasooly R, Goldkorn T. PMID: 11726392; PMCID: PMC4370277.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    35. Regulation of Staphylococcus aureus pathogenesis via target of RNAIII-activating Protein (TRAP). J Biol Chem. 2001 Jan 26; 276(4):2658-67. Balaban N, Goldkorn T, Gov Y, Hirshberg M, Koyfman N, Matthews HR, Nhan RT, Singh B, Uziel O. PMID: 11160124.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    36. Ceramide: a potential mediator of apoptosis in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2001 Jan; 42(1):247-54. Barak A, Morse LS, Goldkorn T. PMID: 11133876.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    37. Ceramide generation and apoptosis in autoimmunity. Clinical and Applied Immunology Reviews. 2001 Jan 1; 1(3-4):173-179. Goldkorn GT. .
      View in: Publisher Site   Mentions:
    38. Ceramide path in human lung cell death. Am J Respir Cell Mol Biol. 2000 Apr; 22(4):460-8. Chan C, Goldkorn T. PMID: 10745027.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    39. Monoclonal anti-endothelial cell antibodies from a patient with Takayasu arteritis activate endothelial cells from large vessels. Arthritis Rheum. 1999 Jul; 42(7):1421-32. Blank M, Krause I, Goldkorn T, Praprotnik S, Livneh A, Langevitz P, Kaganovsky E, Morgenstern S, Cohen S, Barak V, Eldor A, Weksler B, Shoenfeld Y. PMID: 10403270.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    40. Peroxynitrite induces covalent dimerization of epidermal growth factor receptors in A431 epidermoid carcinoma cells. J Biol Chem. 1998 Nov 27; 273(48):31860-6. van der Vliet A, Hristova M, Cross CE, Eiserich JP, Goldkorn T. PMID: 9822654.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    41. H2O2 acts on cellular membranes to generate ceramide signaling and initiate apoptosis in tracheobronchial epithelial cells. J Cell Sci. 1998 Nov; 111 ( Pt 21):3209-20. Goldkorn T, Balaban N, Shannon M, Chea V, Matsukuma K, Gilchrist D, Wang H, Chan C. PMID: 9763515.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    42. EGF-Receptor phosphorylation and signaling are targeted by H2O2 redox stress. Am J Respir Cell Mol Biol. 1998 Nov; 19(5):786-98. Goldkorn T, Balaban N, Matsukuma K, Chea V, Gould R, Last J, Chan C, Chavez C. PMID: 9806743.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    43. Autoinducer of virulence as a target for vaccine and therapy against Staphylococcus aureus. Science. 1998 Apr 17; 280(5362):438-40. Balaban N, Goldkorn T, Nhan RT, Dang LB, Scott S, Ridgley RM, Rasooly A, Wright SC, Larrick JW, Rasooly R, Carlson JR. PMID: 9545222.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCellsPHPublic Health
    44. EGF receptor phosphorylation is affected by ionizing radiation. Biochim Biophys Acta. 1997 Oct 11; 1358(3):289-99. Goldkorn T, Balaban N, Shannon M, Matsukuma K. PMID: 9366260.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    45. The rise and fall of ceramide and 1,2-diacylglycerol (DAG): modulation by transforming growth factor-beta 1 (TGF beta 1) and by epidermal growth factor (EGF). Adv Exp Med Biol. 1997; 400A:461-72. Goldkorn T, Ding T. PMID: 9547591.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    46. The effect of ionizing radiation on signal transduction: antibodies to EGF receptor sensitize A431 cells to radiation. Biochim Biophys Acta. 1996 Nov 08; 1314(1-2):147-56. Balaban N, Moni J, Shannon M, Dang L, Murphy E, Goldkorn T. PMID: 8972728.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    47. Transforming growth factor beta modulates phosphorylation of the epidermal growth factor receptor and proliferation of A431 cells. Cell Growth Differ. 1992 Feb; 3(2):101-9. Goldkorn T, Mendelsohn J. PMID: 1504015.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    48. Ceramide stimulates epidermal growth factor receptor phosphorylation in A431 human epidermoid carcinoma cells. Evidence that ceramide may mediate sphingosine action. J Biol Chem. 1991 Aug 25; 266(24):16092-7. Goldkorn T, Dressler KA, Muindi J, Radin NS, Mendelsohn J, Menaldino D, Liotta D, Kolesnick RN. PMID: 1874747.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    49. A simple and efficient enzymatic method for covalent attachment of DNA to cellulose. Application for hybridization-restriction analysis and for in vitro synthesis of DNA probes. Nucleic Acids Res. 1986 Nov 25; 14(22):9171-91. Goldkorn T, Prockop DJ. PMID: 3024131; PMCID: PMC311937.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    50. Functional molecular weight of the lac carrier protein from Escherichia coli as studied by radiation inactivation analysis. Proc Natl Acad Sci U S A. 1984 Feb; 81(4):1021-5. Goldkorn T, Rimon G, Kempner ES, Kaback HR. PMID: 6230670; PMCID: PMC344755.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    51. The lac carrier protein from Escherichia coli. Soc Gen Physiol Ser. 1984; 38:323-30. Kaback HR, Carrasco N, Foster D, Garcia ML, Goldkorn T, Patel L, Viitanen P. PMID: 6364369.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    52. Topology of the lac carrier protein in the membrane of Escherichia coli. Proc Natl Acad Sci U S A. 1983 Jun; 80(11):3322-6. Goldkorn T, Rimon G, Kaback HR. PMID: 6344081; PMCID: PMC394034.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    53. Preparation, characterization, and properties of monoclonal antibodies against the lac carrier protein from Escherichia coli. Proc Natl Acad Sci U S A. 1982 Nov; 79(22):6894-8. Carrasco N, Tahara SM, Patel L, Goldkorn T, Kaback HR. PMID: 6757923; PMCID: PMC347240.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    54. Electrostatic effects on the kinetics of oxidation-reduction reactions of c-type cytochromes. J Biol Chem. 1979 Dec 25; 254(24):12562-6. Goldkorn T, Schejter A. PMID: 227900.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    55. The reaction of ferric cytochrome c with dithionite at very low ionic strength. FEBS Lett. 1977 Oct 15; 82(2):293-6. Goldkorn T, Schejter A. PMID: 199462.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    56. Kinetic and spectroscopic evidence for different forms of ferric cytochrome c at very low ionic strength and neutral pH. FEBS Lett. 1977 Mar 15; 75(1):44-6. Goldkorn T, Schejter A. PMID: 15867.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    57. The redox potential of cytochrome c-552 from Euglena gracillis: a thermodynamic study. Arch Biochem Biophys. 1976 Nov; 177(1):39-45. Goldkorn T, Schejter A. PMID: 187126.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    58. Ligand-binding reactions and oxidation-reduction equilibria of cytochrome c. Ann N Y Acad Sci. 1975 Apr 15; 244:51-9. Schejter A, Aviram I, Margalit R, Goldkorn T. PMID: 166594.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    59. Limited proteolysis of horse heart cytochrome c. Eur J Biochem. 1971 Jun 11; 20(3):414-9. Schejter A, Goldkorn T, Sokolovsky M. PMID: 5104074.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
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