Anne A. Knowlton

Title(s)Professor, Cardiovascular Medicine
SchoolSchool of Veterinary Medicine
AddressGBSF 6317
CA 95616
Phone530-752-5461
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    Collapse Research 
    Collapse Research Activities and Funding
    Vascular Inflammation and Exosomes as Mediators in Aging and Dementia
    NIH/NIA R01AG056710Mar 15, 2018 - Feb 28, 2023
    Role: Principal Investigator
    Estrogen, Aging and Vascular Inflammation
    VA I01BX000839Oct 1, 2010 - Sep 30, 2014
    Role: Principal Investigator
    Training Program in Basic and Translational Cardiovascular Science
    NIH T32HL086350Dec 1, 2006 - Jun 30, 2023
    Role: Co-Principal Investigator
    HSP60, Inflammation and Cardiovascular Disease
    NIH/NHLBI R01HL079071Dec 1, 2004 - Jun 30, 2015
    Role: Principal Investigator
    Human Cardiomyopathy and HSP60
    NIH/NHLBI R01HL077281Jul 1, 2004 - Jun 30, 2014
    Role: Principal Investigator
    AGING, ESTROGEN, HSPS AND MYOCARDIAL ISCHEMIA
    NIH/NIA R01AG019327May 15, 2001 - Apr 30, 2007
    Role: Principal Investigator
    PHOSPHORYLATION OF HSP 72 AND CARDIAC PROTECTION
    NIH/NHLBI R01HL058515Aug 1, 1997 - Jul 31, 2003
    Role: Principal Investigator
    HSP 70 AND MYOCARDIAL PROTECTION
    NIH/NHLBI R29HL052910Jul 1, 1994 - May 31, 1999
    Role: Principal Investigator
    ROLE OF FATTY ACID BINDING PROTEIN IN CARDIAC ISCHEMIA
    NIH/NHLBI K11HL001853Apr 1, 1987 - Mar 31, 1992
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Exosomes in disease and regeneration: biological functions, diagnostics, and beneficial effects. Am J Physiol Heart Circ Physiol. 2020 12 01; 319(6):H1162-H1180. Lin Y, Anderson JD, Rahnama LMA, Gu SV, Knowlton AA. PMID: 32986962; PMCID: PMC7792703.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    2. Heat shock protein 60 and cardiovascular diseases: An intricate love-hate story. Med Res Rev. 2021 01; 41(1):29-71. Krishnan-Sivadoss I, Mijares-Rojas IA, Villarreal-Leal RA, Torre-Amione G, Knowlton AA, Guerrero-Beltrán CE. PMID: 32808366; PMCID: PMC9290735.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    3. Impaired proteostasis in senescent vascular endothelial cells: a perspective on estrogen and oxidative stress in the aging vasculature. Am J Physiol Heart Circ Physiol. 2019 02 01; 316(2):H421-H429. Hwang HV, Lin Y, Rebuffatti MN, Tran DT, Lee L, Gomes AV, Li CS, Knowlton AA. PMID: 30499713.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    4. Exosomes and cardiovascular cell-cell communication. Essays Biochem. 2018 05 15; 62(2):193-204. Poe AJ, Knowlton AA. PMID: 29717058.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    5. Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells. PLoS One. 2018; 13(1):e0190374. Hwang HV, Tran DT, Rebuffatti MN, Li CS, Knowlton AA. PMID: 29315311; PMCID: PMC5760026.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    6. Exosomes as agents of change in the cardiovascular system. J Mol Cell Cardiol. 2017 10; 111:40-50. Poe AJ, Knowlton AA. PMID: 28782514; PMCID: PMC5600701.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    7. Electrotaxis of cardiac progenitor cells, cardiac fibroblasts, and induced pluripotent stem cell-derived cardiac progenitor cells requires serum and is directed via PI3'K pathways. Heart Rhythm. 2017 11; 14(11):1685-1692. Frederich BJ, Timofeyev V, Thai PN, Haddad MJ, Poe AJ, Lau VC, Moshref M, Knowlton AA, Sirish P, Chiamvimonvat N. PMID: 28668623; PMCID: PMC5671891.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    8. Paying for the Tolls: The High Cost of the Innate Immune System for the Cardiac Myocyte. Adv Exp Med Biol. 2017; 1003:17-34. Knowlton AA. PMID: 28667552.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    9. Distinct subcellular mechanisms for the enhancement of the surface membrane expression of SK2 channel by its interacting proteins, α-actinin2 and filamin A. J Physiol. 2017 04 01; 595(7):2271-2284. Zhang Z, Ledford HA, Park S, Wang W, Rafizadeh S, Kim HJ, Xu W, Lu L, Lau VC, Knowlton AA, Zhang XD, Yamoah EN, Chiamvimonvat N. PMID: 27779751; PMCID: PMC5374114.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    10. 11,12-Epoxyecosatrienoic acids mitigate endothelial dysfunction associated with estrogen loss and aging: Role of membrane depolarization. J Mol Cell Cardiol. 2016 05; 94:180-188. Sun C, Simon SI, Foster GA, Radecke CE, Hwang HV, Zhang X, Hammock BD, Chiamvimonvat N, Knowlton AA. PMID: 27079253; PMCID: PMC4972711.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    11. Cardiac Myocyte Exosome Isolation. Methods Mol Biol. 2016; 1448:237-48. Malik ZA, Liu TT, Knowlton AA. PMID: 27317185; PMCID: PMC5693424.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    12. Mitochondrial Dynamics and Heart Failure. Compr Physiol. 2015 Dec 15; 6(1):507-26. Knowlton AA, Liu TT. PMID: 26756641; PMCID: PMC5695672.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    13. Feedback mechanisms for cardiac-specific microRNAs and cAMP signaling in electrical remodeling. Circ Arrhythm Electrophysiol. 2015 Aug; 8(4):942-50. Myers R, Timofeyev V, Li N, Kim C, Ledford HA, Sirish P, Lau V, Zhang Y, Fayyaz K, Singapuri A, Lopez JE, Knowlton AA, Zhang XD, Chiamvimonvat N. PMID: 25995211; PMCID: PMC4545299.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    14. TLR4 mutation and HSP60-induced cell death in adult mouse cardiac myocytes. Cell Stress Chaperones. 2015 May; 20(3):527-35. Heiserman JP, Chen L, Kim BS, Kim SC, Tran AL, Siebenborn N, Knowlton AA. PMID: 25716072; PMCID: PMC4406935.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    15. Regulation of gene transcription by voltage-gated L-type calcium channel, Cav1.3. J Biol Chem. 2015 Feb 20; 290(8):4663-4676. Lu L, Sirish P, Zhang Z, Woltz RL, Li N, Timofeyev V, Knowlton AA, Zhang XD, Yamoah EN, Chiamvimonvat N. PMID: 25538241; PMCID: PMC4335206.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    16. Mitochondrial dynamic changes in health and genetic diseases. Mol Biol Rep. 2014 Nov; 41(11):7053-62. Chen L, Winger AJ, Knowlton AA. PMID: 25103020; PMCID: PMC5683169.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    17. Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca2+-activated K+ (SK2) channel. Proc Natl Acad Sci U S A. 2014 Jul 08; 111(27):9989-94. Rafizadeh S, Zhang Z, Woltz RL, Kim HJ, Myers RE, Lu L, Tuteja D, Singapuri A, Bigdeli AA, Harchache SB, Knowlton AA, Yarov-Yarovoy V, Yamoah EN, Chiamvimonvat N. PMID: 24951510; PMCID: PMC4103345.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    18. Heart failure and mitochondrial dysfunction: the role of mitochondrial fission/fusion abnormalities and new therapeutic strategies. J Cardiovasc Pharmacol. 2014 Mar; 63(3):196-206. Knowlton AA, Chen L, Malik ZA. PMID: 23884159; PMCID: PMC4088994.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    19. Mitochondrial proteome remodeling in ischemic heart failure. Life Sci. 2014 Apr 17; 101(1-2):27-36. Liu T, Chen L, Kim E, Tran D, Phinney BS, Knowlton AA. PMID: 24548633; PMCID: PMC4075482.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    20. Innate immunity and cardiomyocytes in ischemic heart disease. Life Sci. 2014 Mar 28; 100(1):1-8. Lin L, Knowlton AA. PMID: 24486305; PMCID: PMC3970925.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    21. Estrogen and the female heart. Mol Cell Endocrinol. 2014 May 25; 389(1-2):31-9. Knowlton AA, Korzick DH. PMID: 24462775; PMCID: PMC5709037.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    22. Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure. Circ Res. 2014 Jan 17; 114(2):295-306. Yang Y, Guo T, Oda T, Chakraborty A, Chen L, Uchinoumi H, Knowlton AA, Fruen BR, Cornea RL, Meissner G, Bers DM. PMID: 24186966; PMCID: PMC4004530.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    23. Aging, estrogen loss and epoxyeicosatrienoic acids (EETs). PLoS One. 2013; 8(8):e70719. Lee AR, Pechenino AS, Dong H, Hammock BD, Knowlton AA. PMID: 23967089; PMCID: PMC3742755.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    24. Training the translational research teams of the future: UC Davis-HHMI Integrating Medicine into Basic Science program. Clin Transl Sci. 2013 Oct; 6(5):339-46. Knowlton AA, Rainwater JA, Chiamvimonvat N, Bonham AC, Robbins JA, Henderson S, Meyers FJ. PMID: 24127920; PMCID: PMC3801412.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    25. Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes. Cardiovasc Res. 2013 Jun 01; 98(3):391-401. Tian J, Guo X, Liu XM, Liu L, Weng QF, Dong SJ, Knowlton AA, Yuan WJ, Lin L. PMID: 23447644.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    26. Cardiac myocyte exosomes: stability, HSP60, and proteomics. Am J Physiol Heart Circ Physiol. 2013 Apr 01; 304(7):H954-65. Malik ZA, Kott KS, Poe AJ, Kuo T, Chen L, Ferrara KW, Knowlton AA. PMID: 23376832; PMCID: PMC3625894.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    27. Estrogen, Cardiac Protection and Aging. . 2013 Jan 1; 157-174. Knowlton KA. .
      View in: Publisher Site   Mentions:
    28. OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability. J Am Heart Assoc. 2012 Oct; 1(5):e003012. Chen L, Liu T, Tran A, Lu X, Tomilov AA, Davies V, Cortopassi G, Chiamvimonvat N, Bers DM, Votruba M, Knowlton AA. PMID: 23316298; PMCID: PMC3541627.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    29. Improved Metabolic Control in Diabetes, HSP60, and Proinflammatory Mediators. Autoimmune Dis. 2012; 2012:346501. Blasi C, Kim E, Knowlton AA. PMID: 22924123; PMCID: PMC3424633.
      View in: PubMed   Mentions: 6  
    30. IRF-1 and miRNA126 modulate VCAM-1 expression in response to a high-fat meal. Circ Res. 2012 Sep 28; 111(8):1054-64. Sun C, Alkhoury K, Wang YI, Foster GA, Radecke CE, Tam K, Edwards CM, Facciotti MT, Armstrong EJ, Knowlton AA, Newman JW, Passerini AG, Simon SI. PMID: 22874466; PMCID: PMC3810165.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    31. Rapid activation of nuclear factor κB by 17β-estradiol and selective estrogen receptor modulators: pathways mediating cellular protection. Shock. 2012 Aug; 38(2):128-36. Stice JP, Mbai FN, Chen L, Knowlton AA. PMID: 22683727; PMCID: PMC3401555.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    32. The aging heart and estrogen. Aging Health. 2012 Apr 1; 8(2):163-166. Knowlton KA. .
      View in: Publisher Site   Mentions:
    33. Estrogen and the cardiovascular system. Pharmacol Ther. 2012 Jul; 135(1):54-70. Knowlton AA, Lee AR. PMID: 22484805; PMCID: PMC5688223.
      View in: PubMed   Mentions: 150     Fields:    Translation:HumansAnimalsCells
    34. Regulating a uniter: control of mitofusin 2 expression. Cardiovasc Res. 2012 Apr 01; 94(1):6-7. Knowlton AA, Chen L. PMID: 22362816; PMCID: PMC3307383.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    35. Hyperamylinemia contributes to cardiac dysfunction in obesity and diabetes: a study in humans and rats. Circ Res. 2012 Feb 17; 110(4):598-608. Despa S, Margulies KB, Chen L, Knowlton AA, Havel PJ, Taegtmeyer H, Bers DM, Despa F. PMID: 22275486; PMCID: PMC3303627.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    36. Estrogen and cardiovascular disease: aging and estrogen loss at the heart of the matter? Future Cardiol. 2012 Jan; 8(1):9-12. Knowlton AA. PMID: 22185441.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    37. Mitochondrial dynamics in heart failure. Congest Heart Fail. 2011 Nov-Dec; 17(6):257-61. Chen L, Knowlton AA. PMID: 22848903; PMCID: PMC3410538.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    38. Tocotrienols confer resistance to ischemia in hypercholesterolemic hearts: insight with genomics. Mol Cell Biochem. 2012 Jan; 360(1-2):35-45. Das S, Mukherjee S, Lekli I, Gurusamy N, Bardhan J, Raychoudhury U, Chakravarty R, Banerji S, Knowlton AA, Das DK. PMID: 21918828.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    39. Impact of aging vs. estrogen loss on cardiac gene expression: estrogen replacement and inflammation. Physiol Genomics. 2011 Sep 22; 43(18):1065-73. Pechenino AS, Lin L, Mbai FN, Lee AR, He XM, Stallone JN, Knowlton AA. PMID: 21750230; PMCID: PMC3180739.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    40. The heat shock paradox and cardiac myocytes: role of heat shock factor. Shock. 2011 May; 35(5):478-84. Kobba S, Kim SC, Chen L, Kim E, Tran AL, Knuefermann P, Knowlton AA. PMID: 21192280; PMCID: PMC3435103.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    41. 17β-Estradiol, aging, inflammation, and the stress response in the female heart. Endocrinology. 2011 Apr; 152(4):1589-98. Stice JP, Chen L, Kim SC, Jung JS, Tran AL, Liu TT, Knowlton AA. PMID: 21303943; PMCID: PMC3060632.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    42. CD11c/CD18 expression is upregulated on blood monocytes during hypertriglyceridemia and enhances adhesion to vascular cell adhesion molecule-1. Arterioscler Thromb Vasc Biol. 2011 Jan; 31(1):160-6. Gower RM, Wu H, Foster GA, Devaraj S, Jialal I, Ballantyne CM, Knowlton AA, Simon SI. PMID: 21030716; PMCID: PMC3038249.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansCells
    43. Cardiac small conductance Ca2+-activated K+ channel subunits form heteromultimers via the coiled-coil domains in the C termini of the channels. Circ Res. 2010 Oct 01; 107(7):851-9. Tuteja D, Rafizadeh S, Timofeyev V, Wang S, Zhang Z, Li N, Mateo RK, Singapuri A, Young JN, Knowlton AA, Chiamvimonvat N. PMID: 20689065; PMCID: PMC3732376.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    44. Mitochondria and heart failure: new insights into an energetic problem. Minerva Cardioangiol. 2010 Apr; 58(2):213-29. Chen L, Knowlton AA. PMID: 20440251; PMCID: PMC3786553.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    45. Neutral sphingomyelinase 2 (nSMase2) is a phosphoprotein regulated by calcineurin (PP2B). J Biol Chem. 2010 Apr 02; 285(14):10213-22. Filosto S, Fry W, Knowlton AA, Goldkorn T. PMID: 20106976; PMCID: PMC2856226.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    46. Regulation of heat shock protein 60 and 72 expression in the failing heart. J Mol Cell Cardiol. 2010 Feb; 48(2):360-6. Wang Y, Chen L, Hagiwara N, Knowlton AA. PMID: 19945465; PMCID: PMC2814075.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    47. Extracellular heat shock protein 60, cardiac myocytes, and apoptosis. Circ Res. 2009 Dec 04; 105(12):1186-95. Kim SC, Stice JP, Chen L, Jung JS, Gupta S, Wang Y, Baumgarten G, Trial J, Knowlton AA. PMID: 19875724; PMCID: PMC2949276.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    48. Mitochondrial OPA1, apoptosis, and heart failure. Cardiovasc Res. 2009 Oct 01; 84(1):91-9. Chen L, Gong Q, Stice JP, Knowlton AA. PMID: 19493956; PMCID: PMC2741347.
      View in: PubMed   Mentions: 193     Fields:    Translation:HumansAnimalsCells
    49. Estrogen, aging and the cardiovascular system. Future Cardiol. 2009 Jan; 5(1):93-103. Stice JP, Lee JS, Pechenino AS, Knowlton AA. PMID: 19371207; PMCID: PMC3972065.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    50. Role of aging versus the loss of estrogens in the reduction in vascular function in female rats. Endocrinology. 2009 Jan; 150(1):212-9. Stice JP, Eiserich JP, Knowlton AA. PMID: 18787021; PMCID: PMC2630896.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    51. Effects of dietary decosahexaenoic acid (DHA) on eNOS in human coronary artery endothelial cells. J Cardiovasc Pharmacol Ther. 2008 Dec; 13(4):261-8. Stebbins CL, Stice JP, Hart CM, Mbai FN, Knowlton AA. PMID: 18682551; PMCID: PMC4437661.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    52. Estrogen, NFkappaB, and the heat shock response. Mol Med. 2008 Jul-Aug; 14(7-8):517-27. Stice JP, Knowlton AA. PMID: 18431462; PMCID: PMC2323333.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    53. Heat-shock protein 60 and cardiovascular disease: a paradoxical role. Future Cardiol. 2008 Mar; 4(2):151-61. Knowlton AA, Srivatsa U. PMID: 19804293.
      View in: PubMed   Mentions: 12     Fields:    
    54. Effect of ovariectomy on cardiac gene expression: inflammation and changes in SOCS gene expression. Physiol Genomics. 2008 Jan 17; 32(2):254-63. Hamilton KL, Lin L, Wang Y, Knowlton AA. PMID: 17986523.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    55. HSP60 in heart failure: abnormal distribution and role in cardiac myocyte apoptosis. Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2238-47. Lin L, Kim SC, Wang Y, Gupta S, Davis B, Simon SI, Torre-Amione G, Knowlton AA. PMID: 17675567.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    56. Toll-like receptor 4 deficiency: smaller infarcts, but no gain in function. BMC Physiol. 2007 Jun 25; 7:5. Kim SC, Ghanem A, Stapel H, Tiemann K, Knuefermann P, Hoeft A, Meyer R, Grohé C, Knowlton AA, Baumgarten G. PMID: 17592640; PMCID: PMC1933437.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    57. HSP60 trafficking in adult cardiac myocytes: role of the exosomal pathway. Am J Physiol Heart Circ Physiol. 2007 Jun; 292(6):H3052-6. Gupta S, Knowlton AA. PMID: 17307989.
      View in: PubMed   Mentions: 183     Fields:    Translation:AnimalsCells
    58. Triglyceride-rich lipoproteins prime aortic endothelium for an enhanced inflammatory response to tumor necrosis factor-alpha. Circ Res. 2007 Feb 16; 100(3):381-90. Ting HJ, Stice JP, Schaff UY, Hui DY, Rutledge JC, Knowlton AA, Passerini AG, Simon SI. PMID: 17234968.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    59. Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2. Circ Res. 2007 Jan 05; 100(1):112-20. Lu L, Zhang Q, Timofeyev V, Zhang Z, Young JN, Shin HS, Knowlton AA, Chiamvimonvat N. PMID: 17110593.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    60. Life, death, the unfolded protein response and apoptosis. Cardiovasc Res. 2007 Jan 01; 73(1):1-2. Knowlton AA. PMID: 17145049.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    61. Toll-like receptor 4, nitric oxide, and myocardial depression in endotoxemia. Shock. 2006 Jan; 25(1):43-9. Baumgarten G, Knuefermann P, Schuhmacher G, Vervölgyi V, von Rappard J, Dreiner U, Fink K, Djoufack C, Hoeft A, Grohé C, Knowlton AA, Meyer R. PMID: 16369185.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    62. NFkappaB, heat shock proteins, HSF-1, and inflammation. Cardiovasc Res. 2006 Jan; 69(1):7-8. Knowlton AA. PMID: 16337613.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    63. Effect of mutation of amino acids 246-251 (KRKHKK) in HSP72 on protein synthesis and recovery from hypoxic injury. Am J Physiol Heart Circ Physiol. 2005 Dec; 289(6):H2519-25. Voss MR, Gupta S, Stice JP, Baumgarten G, Lu L, Tristan JM, Knowlton AA. PMID: 16100242.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    64. Gender differences in cardiovascular disease: The effects of estrogen. Drug Discovery Today Disease Mechanisms. 2005 Mar 1; 2(1):65-70. Mbai MF, Hamilton HK, Knowlton KA. .
      View in: Publisher Site   Mentions:
    65. Aging, ischemia and the heart. J Mol Cell Cardiol. 2005 Feb; 38(2):241-4. Mbai FN, Knowlton AA. PMID: 15698830.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    66. HSP60, Bax, apoptosis and the heart. J Cell Mol Med. 2005 Jan-Mar; 9(1):51-8. Gupta S, Knowlton AA. PMID: 15784164; PMCID: PMC6741334.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    67. Estrogen, heat shock proteins, and NFkappaB in human vascular endothelium. Arterioscler Thromb Vasc Biol. 2004 Sep; 24(9):1628-33. Hamilton KL, Mbai FN, Gupta S, Knowlton AA. PMID: 15231513.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    68. Inflammation and ischemia: macrophages activated by fibronectin fragments enhance the survival of injured cardiac myocytes. Exp Biol Med (Maywood). 2004 Jun; 229(6):538-45. Trial J, Rossen RD, Rubio J, Knowlton AA. PMID: 15169973; PMCID: PMC4773909.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    69. Estrogen and regulation of heat shock protein expression in female cardiomyocytes: cross-talk with NF kappa B signaling. J Mol Cell Cardiol. 2004 Apr; 36(4):577-84. Hamilton KL, Gupta S, Knowlton AA. PMID: 15081317.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    70. Glutathione S-transferase pi is upregulated in the stromal compartment of hormone independent prostate cancer. Prostate. 2003 Jul 01; 56(2):98-105. Li M, Ittmann MM, Rowley DR, Knowlton AA, Vaid AK, Epner DE. PMID: 12746833.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    71. Gender differences in the expression of heat shock proteins: the effect of estrogen. Am J Physiol Heart Circ Physiol. 2003 Aug; 285(2):H687-92. Voss MR, Stallone JN, Li M, Cornelussen RN, Knuefermann P, Knowlton AA. PMID: 12714326.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
    72. Complications of inappropriate use of spironolactone in heart failure: when an old medicine spirals out of new guidelines. J Am Coll Cardiol. 2003 Jan 15; 41(2):211-4. Bozkurt B, Agoston I, Knowlton AA. PMID: 12535810.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCTClinical Trials
    73. HSP60, Bax, and cardiac apoptosis. Cardiovasc Toxicol. 2003; 3(3):263-8. Knowlton AA, Gupta S. PMID: 14555791.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    74. Cytosolic heat shock protein 60, hypoxia, and apoptosis. Circulation. 2002 Nov 19; 106(21):2727-33. Gupta S, Knowlton AA. PMID: 12438300.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    75. Heme-oxygenase-1: versatile sentinel against injury. J Mol Cell Cardiol. 2002 Oct; 34(10):1297-1300. Cornelussen RN, Knowlton AA. PMID: 12392988.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    76. Cytosolic heat shock protein 60, apoptosis, and myocardial injury. Circulation. 2002 Jun 18; 105(24):2899-904. Kirchhoff SR, Gupta S, Knowlton AA. PMID: 12070120.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    77. Hsp72 expression enhances survival in adenosine triphosphate-depleted renal epithelial cells. Cell Stress Chaperones. 2002 Apr; 7(2):137-45. Wang YH, Knowlton AA, Li FH, Borkan SC. PMID: 12380681; PMCID: PMC514811.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    78. Presence of heat shock protein 72 in cardiomyocytes after heat stress. Circulation. 2001 Nov 27; 104(22):E123. Cornelussen RN, van Nieuwenhoven FA, Snoeckx LH, Knowlton AA. PMID: 11723036.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    79. Regulation of prostaglandin A1-induced heat shock protein expression in isolated cardiomyocytes. J Mol Cell Cardiol. 2001 Aug; 33(8):1447-54. Cornelussen RN, Gupta S, Knowlton AA. PMID: 11448133.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    80. Congestive heart failure and outpatient risk of venous thromboembolism: a retrospective, case-control study. J Clin Epidemiol. 2001 Aug; 54(8):810-6. Howell MD, Geraci JM, Knowlton AA. PMID: 11470390.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    81. Activation of heat-shock factor by stretch-activated channels in rat hearts. Circulation. 2001 Jul 10; 104(2):209-14. Chang J, Wasser JS, Cornelussen RN, Knowlton AA. PMID: 11447088.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    82. Heat-shock factor-1, steroid hormones, and regulation of heat-shock protein expression in the heart. Am J Physiol Heart Circ Physiol. 2001 Jan; 280(1):H455-64. Knowlton AA, Sun L. PMID: 11123263.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    83. Activation of the heat shock response: relationship to energy metabolites. A (31)P NMR study in rat hearts. Am J Physiol Heart Circ Physiol. 2001 Jan; 280(1):H426-33. Chang J, Knowlton AA, Xu F, Wasser JS. PMID: 11123260.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    84. Mutation of amino acids 566-572 (KKKVLDK) inhibits nuclear accumulation of heat shock protein 72 after heat shock. J Mol Cell Cardiol. 2001 Jan; 33(1):49-55. Knowlton AA. PMID: 11133222.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    85. Spironolactone for heart failure: spiraling out of control. Chest. 2000 Dec; 118(6):1522-3. Geraci JM, Knowlton AA. PMID: 11115427.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    86. Phosphorylation at tyrosine-524 influences nuclear accumulation of HSP72 with heat stress. Am J Physiol Heart Circ Physiol. 2000 Jun; 278(6):H2143-9. Knowlton AA, Grenier M, Kirchhoff SR, Salfity M. PMID: 10843914.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    87. Activation of HSF and selective increase in heat-shock proteins by acute dexamethasone treatment. Am J Physiol Heart Circ Physiol. 2000 Apr; 278(4):H1091-7. Sun L, Chang J, Kirchhoff SR, Knowlton AA. PMID: 10749702.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    88. Expression of heat shock proteins in turtle and mammal hearts: relationship to anoxia tolerance. Am J Physiol Regul Integr Comp Physiol. 2000 Jan; 278(1):R209-14. Chang J, Knowlton AA, Wasser JS. PMID: 10644641.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    89. Prior heat stress inhibits apoptosis in adenosine triphosphate-depleted renal tubular cells. Kidney Int. 1999 Jun; 55(6):2224-35. Wang Y, Knowlton AA, Christensen TG, Shih T, Borkan SC. PMID: 10354271.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    90. Mutation of amino acids 246-251 alters nuclear accumulation of human heat shock protein (HSP) 72 with stress, but does not reduce viability. J Mol Cell Cardiol. 1999 Mar; 31(3):523-32. Knowlton AA. PMID: 10198184.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    91. Tumor necrosis factor-alpha confers resistance to hypoxic injury in the adult mammalian cardiac myocyte. Circulation. 1998 Apr 14; 97(14):1392-400. Nakano M, Knowlton AA, Dibbs Z, Mann DL. PMID: 9577951.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    92. Differential expression of heat shock proteins in normal and failing human hearts. J Mol Cell Cardiol. 1998 Apr; 30(4):811-8. Knowlton AA, Kapadia S, Torre-Amione G, Durand JB, Bies R, Young J, Mann DL. PMID: 9602430.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    93. Blocking the endogenous increase in HSP 72 increases susceptibility to hypoxia and reoxygenation in isolated adult feline cardiocytes. Circulation. 1997 Mar 18; 95(6):1523-31. Nakano M, Mann DL, Knowlton AA. PMID: 9118521.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    94. Tumor necrosis factor-alpha-induced expression of heat shock protein 72 in adult feline cardiac myocytes. Am J Physiol. 1996 Apr; 270(4 Pt 2):H1231-9. Nakano M, Knowlton AA, Yokoyama T, Lesslauer W, Mann DL. PMID: 8967361.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    95. The role of heat shock proteins in the heart. J Mol Cell Cardiol. 1995 Jan; 27(1):121-31. Knowlton AA. PMID: 7760337.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    96. Current concepts in transcription, translation, and the regulation of gene expression. A primer for the clinician. Chest. 1995 Jan; 107(1):241-8. Knowlton AA. PMID: 7813285.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    97. Late preconditioning against myocardial stunning. An endogenous protective mechanism that confers resistance to postischemic dysfunction 24 h after brief ischemia in conscious pigs. J Clin Invest. 1995 Jan; 95(1):388-403. Sun JZ, Tang XL, Knowlton AA, Park SW, Qiu Y, Bolli R. PMID: 7814639; PMCID: PMC295442.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    98. Heat-shock proteins, stress, and the heart. Ann N Y Acad Sci. 1994 Jun 17; 723:128-37. Knowlton AA. PMID: 8030860.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    99. Rapid expression of fibronectin in the rabbit heart after myocardial infarction with and without reperfusion. J Clin Invest. 1992 Apr; 89(4):1060-8. Knowlton AA, Connelly CM, Romo GM, Mamuya W, Apstein CS, Brecher P. PMID: 1556175; PMCID: PMC442961.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
    100. A single myocardial stretch or decreased systolic fiber shortening stimulates the expression of heat shock protein 70 in the isolated, erythrocyte-perfused rabbit heart. J Clin Invest. 1991 Dec; 88(6):2018-25. Knowlton AA, Eberli FR, Brecher P, Romo GM, Owen A, Apstein CS. PMID: 1752959; PMCID: PMC295790.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    101. Rapid expression of heat shock protein in the rabbit after brief cardiac ischemia. J Clin Invest. 1991 Jan; 87(1):139-47. Knowlton AA, Brecher P, Apstein CS. PMID: 1985091; PMCID: PMC295010.
      View in: PubMed   Mentions: 46     Fields:    Translation:Animals
    102. Paradoxical increase in heart rate before conversion to sinus rhythm in patients with recent-onset atrial fibrillation. Am J Cardiol. 1990 Apr 01; 65(13):930-2. Knowlton AA, Falk RH. PMID: 2321547.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    103. Rabbit heart fatty acid-binding protein. Isolation, characterization, and application of a monoclonal antibody. Circ Res. 1989 Oct; 65(4):981-8. Knowlton AA, Burrier RE, Brecher P. PMID: 2791232.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    104. Leakage of heart fatty acid binding protein with ischemia and reperfusion in the rat. J Mol Cell Cardiol. 1989 Jun; 21(6):577-83. Knowlton AA, Apstein CS, Saouf R, Brecher P. PMID: 2778809.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    105. Acute rhabdomyolysis associated with cocaine intoxication. N Engl J Med. 1989 Mar 09; 320(10):667-8. PMID: 2918879.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    106. Purulent pericarditis and ventricular pseudoaneurysm in an intravenous drug abuser. Am Heart J. 1988 Dec; 116(6 Pt 1):1635-7. Wiegers SE, Plehn JF, Rajail-Khorasani A, Knowlton AA. PMID: 3195447.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    107. The effect of propranolol and verapamil on external pacing threshold: a placebo-controlled study. Pacing Clin Electrophysiol. 1988 Oct; 11(10):1439-43. Falk RH, Knowlton AA, Battinelli NJ. PMID: 2462221.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    108. Verapamil-induced atrial fibrillation. N Engl J Med. 1988 Mar 10; 318(10):640-1. Falk RH, Knowlton AA, Manaker S. PMID: 3344011.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    109. Digoxin for converting recent-onset atrial fibrillation to sinus rhythm. A randomized, double-blinded trial. Ann Intern Med. 1987 Apr; 106(4):503-6. Falk RH, Knowlton AA, Bernard SA, Gotlieb NE, Battinelli NJ. PMID: 3548521.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCTClinical Trials
    110. Atypical ventricular tachycardia or motion artifact? Am J Cardiol. 1987 Apr 01; 59(8):924. Falk RH, Knowlton AA. PMID: 3825957.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    111. External cardiac pacing during in-hospital cardiac arrest. Am J Cardiol. 1986 Jun 01; 57(15):1295-8. Knowlton AA, Falk RH. PMID: 3717028.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
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