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Exosomes in disease and regeneration: biological functions, diagnostics, and beneficial effects. Am J Physiol Heart Circ Physiol. 2020 12 01; 319(6):H1162-H1180.
Lin Y, Anderson JD, Rahnama LMA, Gu SV, Knowlton AA. PMID: 32986962; PMCID: PMC7792703.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Heat shock protein 60 and cardiovascular diseases: An intricate love-hate story. Med Res Rev. 2021 01; 41(1):29-71.
Krishnan-Sivadoss I, Mijares-Rojas IA, Villarreal-Leal RA, Torre-Amione G, Knowlton AA, Guerrero-Beltrán CE. PMID: 32808366; PMCID: PMC9290735.
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PubMed Mentions:
18 Fields:
Translation:
Humans
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Impaired proteostasis in senescent vascular endothelial cells: a perspective on estrogen and oxidative stress in the aging vasculature. Am J Physiol Heart Circ Physiol. 2019 02 01; 316(2):H421-H429.
Hwang HV, Lin Y, Rebuffatti MN, Tran DT, Lee L, Gomes AV, Li CS, Knowlton AA. PMID: 30499713.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Exosomes and cardiovascular cell-cell communication. Essays Biochem. 2018 05 15; 62(2):193-204.
Poe AJ, Knowlton AA. PMID: 29717058.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells. PLoS One. 2018; 13(1):e0190374.
Hwang HV, Tran DT, Rebuffatti MN, Li CS, Knowlton AA. PMID: 29315311; PMCID: PMC5760026.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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Exosomes as agents of change in the cardiovascular system. J Mol Cell Cardiol. 2017 10; 111:40-50.
Poe AJ, Knowlton AA. PMID: 28782514; PMCID: PMC5600701.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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Electrotaxis of cardiac progenitor cells, cardiac fibroblasts, and induced pluripotent stem cell-derived cardiac progenitor cells requires serum and is directed via PI3'K pathways. Heart Rhythm. 2017 11; 14(11):1685-1692.
Frederich BJ, Timofeyev V, Thai PN, Haddad MJ, Poe AJ, Lau VC, Moshref M, Knowlton AA, Sirish P, Chiamvimonvat N. PMID: 28668623; PMCID: PMC5671891.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Paying for the Tolls: The High Cost of the Innate Immune System for the Cardiac Myocyte. Adv Exp Med Biol. 2017; 1003:17-34.
Knowlton AA. PMID: 28667552.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Distinct subcellular mechanisms for the enhancement of the surface membrane expression of SK2 channel by its interacting proteins, α-actinin2 and filamin A. J Physiol. 2017 04 01; 595(7):2271-2284.
Zhang Z, Ledford HA, Park S, Wang W, Rafizadeh S, Kim HJ, Xu W, Lu L, Lau VC, Knowlton AA, Zhang XD, Yamoah EN, Chiamvimonvat N. PMID: 27779751; PMCID: PMC5374114.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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11,12-Epoxyecosatrienoic acids mitigate endothelial dysfunction associated with estrogen loss and aging: Role of membrane depolarization. J Mol Cell Cardiol. 2016 05; 94:180-188.
Sun C, Simon SI, Foster GA, Radecke CE, Hwang HV, Zhang X, Hammock BD, Chiamvimonvat N, Knowlton AA. PMID: 27079253; PMCID: PMC4972711.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Cardiac Myocyte Exosome Isolation. Methods Mol Biol. 2016; 1448:237-48.
Malik ZA, Liu TT, Knowlton AA. PMID: 27317185; PMCID: PMC5693424.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Mitochondrial Dynamics and Heart Failure. Compr Physiol. 2015 Dec 15; 6(1):507-26.
Knowlton AA, Liu TT. PMID: 26756641; PMCID: PMC5695672.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Feedback mechanisms for cardiac-specific microRNAs and cAMP signaling in electrical remodeling. Circ Arrhythm Electrophysiol. 2015 Aug; 8(4):942-50.
Myers R, Timofeyev V, Li N, Kim C, Ledford HA, Sirish P, Lau V, Zhang Y, Fayyaz K, Singapuri A, Lopez JE, Knowlton AA, Zhang XD, Chiamvimonvat N. PMID: 25995211; PMCID: PMC4545299.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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TLR4 mutation and HSP60-induced cell death in adult mouse cardiac myocytes. Cell Stress Chaperones. 2015 May; 20(3):527-35.
Heiserman JP, Chen L, Kim BS, Kim SC, Tran AL, Siebenborn N, Knowlton AA. PMID: 25716072; PMCID: PMC4406935.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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Regulation of gene transcription by voltage-gated L-type calcium channel, Cav1.3. J Biol Chem. 2015 Feb 20; 290(8):4663-4676.
Lu L, Sirish P, Zhang Z, Woltz RL, Li N, Timofeyev V, Knowlton AA, Zhang XD, Yamoah EN, Chiamvimonvat N. PMID: 25538241; PMCID: PMC4335206.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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Mitochondrial dynamic changes in health and genetic diseases. Mol Biol Rep. 2014 Nov; 41(11):7053-62.
Chen L, Winger AJ, Knowlton AA. PMID: 25103020; PMCID: PMC5683169.
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PubMed Mentions:
15 Fields:
Translation:
Humans
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Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca2+-activated K+ (SK2) channel. Proc Natl Acad Sci U S A. 2014 Jul 08; 111(27):9989-94.
Rafizadeh S, Zhang Z, Woltz RL, Kim HJ, Myers RE, Lu L, Tuteja D, Singapuri A, Bigdeli AA, Harchache SB, Knowlton AA, Yarov-Yarovoy V, Yamoah EN, Chiamvimonvat N. PMID: 24951510; PMCID: PMC4103345.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
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Heart failure and mitochondrial dysfunction: the role of mitochondrial fission/fusion abnormalities and new therapeutic strategies. J Cardiovasc Pharmacol. 2014 Mar; 63(3):196-206.
Knowlton AA, Chen L, Malik ZA. PMID: 23884159; PMCID: PMC4088994.
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PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
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Mitochondrial proteome remodeling in ischemic heart failure. Life Sci. 2014 Apr 17; 101(1-2):27-36.
Liu T, Chen L, Kim E, Tran D, Phinney BS, Knowlton AA. PMID: 24548633; PMCID: PMC4075482.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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Innate immunity and cardiomyocytes in ischemic heart disease. Life Sci. 2014 Mar 28; 100(1):1-8.
Lin L, Knowlton AA. PMID: 24486305; PMCID: PMC3970925.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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Estrogen and the female heart. Mol Cell Endocrinol. 2014 May 25; 389(1-2):31-9.
Knowlton AA, Korzick DH. PMID: 24462775; PMCID: PMC5709037.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimals
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Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure. Circ Res. 2014 Jan 17; 114(2):295-306.
Yang Y, Guo T, Oda T, Chakraborty A, Chen L, Uchinoumi H, Knowlton AA, Fruen BR, Cornea RL, Meissner G, Bers DM. PMID: 24186966; PMCID: PMC4004530.
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PubMed Mentions:
43 Fields:
Translation:
AnimalsCells
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Aging, estrogen loss and epoxyeicosatrienoic acids (EETs). PLoS One. 2013; 8(8):e70719.
Lee AR, Pechenino AS, Dong H, Hammock BD, Knowlton AA. PMID: 23967089; PMCID: PMC3742755.
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PubMed Mentions:
6 Fields:
Translation:
Animals
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Training the translational research teams of the future: UC Davis-HHMI Integrating Medicine into Basic Science program. Clin Transl Sci. 2013 Oct; 6(5):339-46.
Knowlton AA, Rainwater JA, Chiamvimonvat N, Bonham AC, Robbins JA, Henderson S, Meyers FJ. PMID: 24127920; PMCID: PMC3801412.
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PubMed Mentions:
13 Fields:
Translation:
Humans
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Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes. Cardiovasc Res. 2013 Jun 01; 98(3):391-401.
Tian J, Guo X, Liu XM, Liu L, Weng QF, Dong SJ, Knowlton AA, Yuan WJ, Lin L. PMID: 23447644.
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PubMed Mentions:
63 Fields:
Translation:
AnimalsCells
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Cardiac myocyte exosomes: stability, HSP60, and proteomics. Am J Physiol Heart Circ Physiol. 2013 Apr 01; 304(7):H954-65.
Malik ZA, Kott KS, Poe AJ, Kuo T, Chen L, Ferrara KW, Knowlton AA. PMID: 23376832; PMCID: PMC3625894.
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PubMed Mentions:
110 Fields:
Translation:
AnimalsCells
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Estrogen, Cardiac Protection and Aging. . 2013 Jan 1; 157-174.
Knowlton KA. .
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Publisher Site Mentions:
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OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability. J Am Heart Assoc. 2012 Oct; 1(5):e003012.
Chen L, Liu T, Tran A, Lu X, Tomilov AA, Davies V, Cortopassi G, Chiamvimonvat N, Bers DM, Votruba M, Knowlton AA. PMID: 23316298; PMCID: PMC3541627.
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PubMed Mentions:
101 Fields:
Translation:
AnimalsCells
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Improved Metabolic Control in Diabetes, HSP60, and Proinflammatory Mediators. Autoimmune Dis. 2012; 2012:346501.
Blasi C, Kim E, Knowlton AA. PMID: 22924123; PMCID: PMC3424633.
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PubMed Mentions:
6
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IRF-1 and miRNA126 modulate VCAM-1 expression in response to a high-fat meal. Circ Res. 2012 Sep 28; 111(8):1054-64.
Sun C, Alkhoury K, Wang YI, Foster GA, Radecke CE, Tam K, Edwards CM, Facciotti MT, Armstrong EJ, Knowlton AA, Newman JW, Passerini AG, Simon SI. PMID: 22874466; PMCID: PMC3810165.
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PubMed Mentions:
46 Fields:
Translation:
HumansCells
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Rapid activation of nuclear factor κB by 17β-estradiol and selective estrogen receptor modulators: pathways mediating cellular protection. Shock. 2012 Aug; 38(2):128-36.
Stice JP, Mbai FN, Chen L, Knowlton AA. PMID: 22683727; PMCID: PMC3401555.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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The aging heart and estrogen. Aging Health. 2012 Apr 1; 8(2):163-166.
Knowlton KA. .
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Publisher Site Mentions:
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Estrogen and the cardiovascular system. Pharmacol Ther. 2012 Jul; 135(1):54-70.
Knowlton AA, Lee AR. PMID: 22484805; PMCID: PMC5688223.
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PubMed Mentions:
161 Fields:
Translation:
HumansAnimalsCells
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Regulating a uniter: control of mitofusin 2 expression. Cardiovasc Res. 2012 Apr 01; 94(1):6-7.
Knowlton AA, Chen L. PMID: 22362816; PMCID: PMC3307383.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Hyperamylinemia contributes to cardiac dysfunction in obesity and diabetes: a study in humans and rats. Circ Res. 2012 Feb 17; 110(4):598-608.
Despa S, Margulies KB, Chen L, Knowlton AA, Havel PJ, Taegtmeyer H, Bers DM, Despa F. PMID: 22275486; PMCID: PMC3303627.
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PubMed Mentions:
76 Fields:
Translation:
HumansAnimalsCells
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Estrogen and cardiovascular disease: aging and estrogen loss at the heart of the matter? Future Cardiol. 2012 Jan; 8(1):9-12.
Knowlton AA. PMID: 22185441.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Mitochondrial dynamics in heart failure. Congest Heart Fail. 2011 Nov-Dec; 17(6):257-61.
Chen L, Knowlton AA. PMID: 22848903; PMCID: PMC3410538.
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PubMed Mentions:
32 Fields:
Translation:
HumansCells
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Tocotrienols confer resistance to ischemia in hypercholesterolemic hearts: insight with genomics. Mol Cell Biochem. 2012 Jan; 360(1-2):35-45.
Das S, Mukherjee S, Lekli I, Gurusamy N, Bardhan J, Raychoudhury U, Chakravarty R, Banerji S, Knowlton AA, Das DK. PMID: 21918828.
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PubMed Mentions:
10 Fields:
Translation:
Animals
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Impact of aging vs. estrogen loss on cardiac gene expression: estrogen replacement and inflammation. Physiol Genomics. 2011 Sep 22; 43(18):1065-73.
Pechenino AS, Lin L, Mbai FN, Lee AR, He XM, Stallone JN, Knowlton AA. PMID: 21750230; PMCID: PMC3180739.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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The heat shock paradox and cardiac myocytes: role of heat shock factor. Shock. 2011 May; 35(5):478-84.
Kobba S, Kim SC, Chen L, Kim E, Tran AL, Knuefermann P, Knowlton AA. PMID: 21192280; PMCID: PMC3435103.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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17β-Estradiol, aging, inflammation, and the stress response in the female heart. Endocrinology. 2011 Apr; 152(4):1589-98.
Stice JP, Chen L, Kim SC, Jung JS, Tran AL, Liu TT, Knowlton AA. PMID: 21303943; PMCID: PMC3060632.
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PubMed Mentions:
40 Fields:
Translation:
AnimalsCells
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CD11c/CD18 expression is upregulated on blood monocytes during hypertriglyceridemia and enhances adhesion to vascular cell adhesion molecule-1. Arterioscler Thromb Vasc Biol. 2011 Jan; 31(1):160-6.
Gower RM, Wu H, Foster GA, Devaraj S, Jialal I, Ballantyne CM, Knowlton AA, Simon SI. PMID: 21030716; PMCID: PMC3038249.
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PubMed Mentions:
79 Fields:
Translation:
HumansCells
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Cardiac small conductance Ca2+-activated K+ channel subunits form heteromultimers via the coiled-coil domains in the C termini of the channels. Circ Res. 2010 Oct 01; 107(7):851-9.
Tuteja D, Rafizadeh S, Timofeyev V, Wang S, Zhang Z, Li N, Mateo RK, Singapuri A, Young JN, Knowlton AA, Chiamvimonvat N. PMID: 20689065; PMCID: PMC3732376.
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PubMed Mentions:
51 Fields:
Translation:
HumansAnimalsCells
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Mitochondria and heart failure: new insights into an energetic problem. Minerva Cardioangiol. 2010 Apr; 58(2):213-29.
Chen L, Knowlton AA. PMID: 20440251; PMCID: PMC3786553.
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PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
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Neutral sphingomyelinase 2 (nSMase2) is a phosphoprotein regulated by calcineurin (PP2B). J Biol Chem. 2010 Apr 02; 285(14):10213-22.
Filosto S, Fry W, Knowlton AA, Goldkorn T. PMID: 20106976; PMCID: PMC2856226.
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PubMed Mentions:
37 Fields:
Translation:
HumansCells
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Regulation of heat shock protein 60 and 72 expression in the failing heart. J Mol Cell Cardiol. 2010 Feb; 48(2):360-6.
Wang Y, Chen L, Hagiwara N, Knowlton AA. PMID: 19945465; PMCID: PMC2814075.
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PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
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Extracellular heat shock protein 60, cardiac myocytes, and apoptosis. Circ Res. 2009 Dec 04; 105(12):1186-95.
Kim SC, Stice JP, Chen L, Jung JS, Gupta S, Wang Y, Baumgarten G, Trial J, Knowlton AA. PMID: 19875724; PMCID: PMC2949276.
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PubMed Mentions:
78 Fields:
Translation:
HumansAnimalsCells
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Mitochondrial OPA1, apoptosis, and heart failure. Cardiovasc Res. 2009 Oct 01; 84(1):91-9.
Chen L, Gong Q, Stice JP, Knowlton AA. PMID: 19493956; PMCID: PMC2741347.
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PubMed Mentions:
201 Fields:
Translation:
HumansAnimalsCells
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Estrogen, aging and the cardiovascular system. Future Cardiol. 2009 Jan; 5(1):93-103.
Stice JP, Lee JS, Pechenino AS, Knowlton AA. PMID: 19371207; PMCID: PMC3972065.
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PubMed Mentions:
32 Fields:
Translation:
HumansAnimals
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Role of aging versus the loss of estrogens in the reduction in vascular function in female rats. Endocrinology. 2009 Jan; 150(1):212-9.
Stice JP, Eiserich JP, Knowlton AA. PMID: 18787021; PMCID: PMC2630896.
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PubMed Mentions:
20 Fields:
Translation:
Animals
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Effects of dietary decosahexaenoic acid (DHA) on eNOS in human coronary artery endothelial cells. J Cardiovasc Pharmacol Ther. 2008 Dec; 13(4):261-8.
Stebbins CL, Stice JP, Hart CM, Mbai FN, Knowlton AA. PMID: 18682551; PMCID: PMC4437661.
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PubMed Mentions:
23 Fields:
Translation:
HumansCells
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Estrogen, NFkappaB, and the heat shock response. Mol Med. 2008 Jul-Aug; 14(7-8):517-27.
Stice JP, Knowlton AA. PMID: 18431462; PMCID: PMC2323333.
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PubMed Mentions:
41 Fields:
Translation:
HumansAnimals
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Heat-shock protein 60 and cardiovascular disease: a paradoxical role. Future Cardiol. 2008 Mar; 4(2):151-61.
Knowlton AA, Srivatsa U. PMID: 19804293.
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PubMed Mentions:
12 Fields:
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Effect of ovariectomy on cardiac gene expression: inflammation and changes in SOCS gene expression. Physiol Genomics. 2008 Jan 17; 32(2):254-63.
Hamilton KL, Lin L, Wang Y, Knowlton AA. PMID: 17986523.
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PubMed Mentions:
22 Fields:
Translation:
Animals
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HSP60 in heart failure: abnormal distribution and role in cardiac myocyte apoptosis. Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2238-47.
Lin L, Kim SC, Wang Y, Gupta S, Davis B, Simon SI, Torre-Amione G, Knowlton AA. PMID: 17675567.
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PubMed Mentions:
69 Fields:
Translation:
HumansAnimalsCells
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Toll-like receptor 4 deficiency: smaller infarcts, but no gain in function. BMC Physiol. 2007 Jun 25; 7:5.
Kim SC, Ghanem A, Stapel H, Tiemann K, Knuefermann P, Hoeft A, Meyer R, Grohé C, Knowlton AA, Baumgarten G. PMID: 17592640; PMCID: PMC1933437.
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PubMed Mentions:
31 Fields:
Translation:
Animals
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HSP60 trafficking in adult cardiac myocytes: role of the exosomal pathway. Am J Physiol Heart Circ Physiol. 2007 Jun; 292(6):H3052-6.
Gupta S, Knowlton AA. PMID: 17307989.
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PubMed Mentions:
188 Fields:
Translation:
AnimalsCells
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Triglyceride-rich lipoproteins prime aortic endothelium for an enhanced inflammatory response to tumor necrosis factor-alpha. Circ Res. 2007 Feb 16; 100(3):381-90.
Ting HJ, Stice JP, Schaff UY, Hui DY, Rutledge JC, Knowlton AA, Passerini AG, Simon SI. PMID: 17234968.
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PubMed Mentions:
53 Fields:
Translation:
HumansCells
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Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2. Circ Res. 2007 Jan 05; 100(1):112-20.
Lu L, Zhang Q, Timofeyev V, Zhang Z, Young JN, Shin HS, Knowlton AA, Chiamvimonvat N. PMID: 17110593.
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PubMed Mentions:
79 Fields:
Translation:
HumansAnimalsCells
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Life, death, the unfolded protein response and apoptosis. Cardiovasc Res. 2007 Jan 01; 73(1):1-2.
Knowlton AA. PMID: 17145049.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Toll-like receptor 4, nitric oxide, and myocardial depression in endotoxemia. Shock. 2006 Jan; 25(1):43-9.
Baumgarten G, Knuefermann P, Schuhmacher G, Vervölgyi V, von Rappard J, Dreiner U, Fink K, Djoufack C, Hoeft A, Grohé C, Knowlton AA, Meyer R. PMID: 16369185.
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PubMed Mentions:
48 Fields:
Translation:
AnimalsCells
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NFkappaB, heat shock proteins, HSF-1, and inflammation. Cardiovasc Res. 2006 Jan; 69(1):7-8.
Knowlton AA. PMID: 16337613.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Effect of mutation of amino acids 246-251 (KRKHKK) in HSP72 on protein synthesis and recovery from hypoxic injury. Am J Physiol Heart Circ Physiol. 2005 Dec; 289(6):H2519-25.
Voss MR, Gupta S, Stice JP, Baumgarten G, Lu L, Tristan JM, Knowlton AA. PMID: 16100242.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Gender differences in cardiovascular disease: The effects of estrogen. Drug Discovery Today Disease Mechanisms. 2005 Mar 1; 2(1):65-70.
Mbai MF, Hamilton HK, Knowlton KA. .
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Publisher Site Mentions:
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Aging, ischemia and the heart. J Mol Cell Cardiol. 2005 Feb; 38(2):241-4.
Mbai FN, Knowlton AA. PMID: 15698830.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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HSP60, Bax, apoptosis and the heart. J Cell Mol Med. 2005 Jan-Mar; 9(1):51-8.
Gupta S, Knowlton AA. PMID: 15784164; PMCID: PMC6741334.
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PubMed Mentions:
58 Fields:
Translation:
HumansAnimalsCells
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Estrogen, heat shock proteins, and NFkappaB in human vascular endothelium. Arterioscler Thromb Vasc Biol. 2004 Sep; 24(9):1628-33.
Hamilton KL, Mbai FN, Gupta S, Knowlton AA. PMID: 15231513.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Inflammation and ischemia: macrophages activated by fibronectin fragments enhance the survival of injured cardiac myocytes. Exp Biol Med (Maywood). 2004 Jun; 229(6):538-45.
Trial J, Rossen RD, Rubio J, Knowlton AA. PMID: 15169973; PMCID: PMC4773909.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Estrogen and regulation of heat shock protein expression in female cardiomyocytes: cross-talk with NF kappa B signaling. J Mol Cell Cardiol. 2004 Apr; 36(4):577-84.
Hamilton KL, Gupta S, Knowlton AA. PMID: 15081317.
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PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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Glutathione S-transferase pi is upregulated in the stromal compartment of hormone independent prostate cancer. Prostate. 2003 Jul 01; 56(2):98-105.
Li M, Ittmann MM, Rowley DR, Knowlton AA, Vaid AK, Epner DE. PMID: 12746833.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Gender differences in the expression of heat shock proteins: the effect of estrogen. Am J Physiol Heart Circ Physiol. 2003 Aug; 285(2):H687-92.
Voss MR, Stallone JN, Li M, Cornelussen RN, Knuefermann P, Knowlton AA. PMID: 12714326.
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PubMed Mentions:
43 Fields:
Translation:
Animals
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Complications of inappropriate use of spironolactone in heart failure: when an old medicine spirals out of new guidelines. J Am Coll Cardiol. 2003 Jan 15; 41(2):211-4.
Bozkurt B, Agoston I, Knowlton AA. PMID: 12535810.
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PubMed Mentions:
54 Fields:
Translation:
HumansCTClinical Trials
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HSP60, Bax, and cardiac apoptosis. Cardiovasc Toxicol. 2003; 3(3):263-8.
Knowlton AA, Gupta S. PMID: 14555791.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Cytosolic heat shock protein 60, hypoxia, and apoptosis. Circulation. 2002 Nov 19; 106(21):2727-33.
Gupta S, Knowlton AA. PMID: 12438300.
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PubMed Mentions:
46 Fields:
Translation:
AnimalsCells
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Heme-oxygenase-1: versatile sentinel against injury. J Mol Cell Cardiol. 2002 Oct; 34(10):1297-1300.
Cornelussen RN, Knowlton AA. PMID: 12392988.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Cytosolic heat shock protein 60, apoptosis, and myocardial injury. Circulation. 2002 Jun 18; 105(24):2899-904.
Kirchhoff SR, Gupta S, Knowlton AA. PMID: 12070120.
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PubMed Mentions:
89 Fields:
Translation:
AnimalsCells
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Hsp72 expression enhances survival in adenosine triphosphate-depleted renal epithelial cells. Cell Stress Chaperones. 2002 Apr; 7(2):137-45.
Wang YH, Knowlton AA, Li FH, Borkan SC. PMID: 12380681; PMCID: PMC514811.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimals
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Presence of heat shock protein 72 in cardiomyocytes after heat stress. Circulation. 2001 Nov 27; 104(22):E123.
Cornelussen RN, van Nieuwenhoven FA, Snoeckx LH, Knowlton AA. PMID: 11723036.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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Congestive heart failure and outpatient risk of venous thromboembolism: a retrospective, case-control study. J Clin Epidemiol. 2001 Aug; 54(8):810-6.
Howell MD, Geraci JM, Knowlton AA. PMID: 11470390.
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PubMed Mentions:
35 Fields:
Translation:
Humans
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Regulation of prostaglandin A1-induced heat shock protein expression in isolated cardiomyocytes. J Mol Cell Cardiol. 2001 Aug; 33(8):1447-54.
Cornelussen RN, Gupta S, Knowlton AA. PMID: 11448133.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Activation of heat-shock factor by stretch-activated channels in rat hearts. Circulation. 2001 Jul 10; 104(2):209-14.
Chang J, Wasser JS, Cornelussen RN, Knowlton AA. PMID: 11447088.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Heat-shock factor-1, steroid hormones, and regulation of heat-shock protein expression in the heart. Am J Physiol Heart Circ Physiol. 2001 Jan; 280(1):H455-64.
Knowlton AA, Sun L. PMID: 11123263.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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Mutation of amino acids 566-572 (KKKVLDK) inhibits nuclear accumulation of heat shock protein 72 after heat shock. J Mol Cell Cardiol. 2001 Jan; 33(1):49-55.
Knowlton AA. PMID: 11133222.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Activation of the heat shock response: relationship to energy metabolites. A (31)P NMR study in rat hearts. Am J Physiol Heart Circ Physiol. 2001 Jan; 280(1):H426-33.
Chang J, Knowlton AA, Xu F, Wasser JS. PMID: 11123260.
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PubMed Mentions:
8 Fields:
Translation:
Animals
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Spironolactone for heart failure: spiraling out of control. Chest. 2000 Dec; 118(6):1522-3.
Geraci JM, Knowlton AA. PMID: 11115427.
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Translation:
Humans
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Phosphorylation at tyrosine-524 influences nuclear accumulation of HSP72 with heat stress. Am J Physiol Heart Circ Physiol. 2000 Jun; 278(6):H2143-9.
Knowlton AA, Grenier M, Kirchhoff SR, Salfity M. PMID: 10843914.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Activation of HSF and selective increase in heat-shock proteins by acute dexamethasone treatment. Am J Physiol Heart Circ Physiol. 2000 Apr; 278(4):H1091-7.
Sun L, Chang J, Kirchhoff SR, Knowlton AA. PMID: 10749702.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Expression of heat shock proteins in turtle and mammal hearts: relationship to anoxia tolerance. Am J Physiol Regul Integr Comp Physiol. 2000 Jan; 278(1):R209-14.
Chang J, Knowlton AA, Wasser JS. PMID: 10644641.
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PubMed Mentions:
13 Fields:
Translation:
Animals
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Prior heat stress inhibits apoptosis in adenosine triphosphate-depleted renal tubular cells. Kidney Int. 1999 Jun; 55(6):2224-35.
Wang Y, Knowlton AA, Christensen TG, Shih T, Borkan SC. PMID: 10354271.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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Mutation of amino acids 246-251 alters nuclear accumulation of human heat shock protein (HSP) 72 with stress, but does not reduce viability. J Mol Cell Cardiol. 1999 Mar; 31(3):523-32.
Knowlton AA. PMID: 10198184.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Tumor necrosis factor-alpha confers resistance to hypoxic injury in the adult mammalian cardiac myocyte. Circulation. 1998 Apr 14; 97(14):1392-400.
Nakano M, Knowlton AA, Dibbs Z, Mann DL. PMID: 9577951.
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PubMed Mentions:
31 Fields:
Translation:
Animals
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Differential expression of heat shock proteins in normal and failing human hearts. J Mol Cell Cardiol. 1998 Apr; 30(4):811-8.
Knowlton AA, Kapadia S, Torre-Amione G, Durand JB, Bies R, Young J, Mann DL. PMID: 9602430.
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PubMed Mentions:
53 Fields:
Translation:
Humans
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Blocking the endogenous increase in HSP 72 increases susceptibility to hypoxia and reoxygenation in isolated adult feline cardiocytes. Circulation. 1997 Mar 18; 95(6):1523-31.
Nakano M, Mann DL, Knowlton AA. PMID: 9118521.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Tumor necrosis factor-alpha-induced expression of heat shock protein 72 in adult feline cardiac myocytes. Am J Physiol. 1996 Apr; 270(4 Pt 2):H1231-9.
Nakano M, Knowlton AA, Yokoyama T, Lesslauer W, Mann DL. PMID: 8967361.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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Current concepts in transcription, translation, and the regulation of gene expression. A primer for the clinician. Chest. 1995 Jan; 107(1):241-8.
Knowlton AA. PMID: 7813285.
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Translation:
Cells
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Late preconditioning against myocardial stunning. An endogenous protective mechanism that confers resistance to postischemic dysfunction 24 h after brief ischemia in conscious pigs. J Clin Invest. 1995 Jan; 95(1):388-403.
Sun JZ, Tang XL, Knowlton AA, Park SW, Qiu Y, Bolli R. PMID: 7814639; PMCID: PMC295442.
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PubMed Mentions:
32 Fields:
Translation:
Animals
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The role of heat shock proteins in the heart. J Mol Cell Cardiol. 1995 Jan; 27(1):121-31.
Knowlton AA. PMID: 7760337.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimals
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Heat-shock proteins, stress, and the heart. Ann N Y Acad Sci. 1994 Jun 17; 723:128-37.
Knowlton AA. PMID: 8030860.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Rapid expression of fibronectin in the rabbit heart after myocardial infarction with and without reperfusion. J Clin Invest. 1992 Apr; 89(4):1060-8.
Knowlton AA, Connelly CM, Romo GM, Mamuya W, Apstein CS, Brecher P. PMID: 1556175; PMCID: PMC442961.
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PubMed Mentions:
42 Fields:
Translation:
Animals
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A single myocardial stretch or decreased systolic fiber shortening stimulates the expression of heat shock protein 70 in the isolated, erythrocyte-perfused rabbit heart. J Clin Invest. 1991 Dec; 88(6):2018-25.
Knowlton AA, Eberli FR, Brecher P, Romo GM, Owen A, Apstein CS. PMID: 1752959; PMCID: PMC295790.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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Rapid expression of heat shock protein in the rabbit after brief cardiac ischemia. J Clin Invest. 1991 Jan; 87(1):139-47.
Knowlton AA, Brecher P, Apstein CS. PMID: 1985091; PMCID: PMC295010.
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PubMed Mentions:
47 Fields:
Translation:
Animals
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Paradoxical increase in heart rate before conversion to sinus rhythm in patients with recent-onset atrial fibrillation. Am J Cardiol. 1990 Apr 01; 65(13):930-2.
Knowlton AA, Falk RH. PMID: 2321547.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Rabbit heart fatty acid-binding protein. Isolation, characterization, and application of a monoclonal antibody. Circ Res. 1989 Oct; 65(4):981-8.
Knowlton AA, Burrier RE, Brecher P. PMID: 2791232.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimals
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Leakage of heart fatty acid binding protein with ischemia and reperfusion in the rat. J Mol Cell Cardiol. 1989 Jun; 21(6):577-83.
Knowlton AA, Apstein CS, Saouf R, Brecher P. PMID: 2778809.
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PubMed Mentions:
17 Fields:
Translation:
Animals
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Acute rhabdomyolysis associated with cocaine intoxication. N Engl J Med. 1989 Mar 09; 320(10):667-8.
PMID: 2918879.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Purulent pericarditis and ventricular pseudoaneurysm in an intravenous drug abuser. Am Heart J. 1988 Dec; 116(6 Pt 1):1635-7.
Wiegers SE, Plehn JF, Rajail-Khorasani A, Knowlton AA. PMID: 3195447.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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The effect of propranolol and verapamil on external pacing threshold: a placebo-controlled study. Pacing Clin Electrophysiol. 1988 Oct; 11(10):1439-43.
Falk RH, Knowlton AA, Battinelli NJ. PMID: 2462221.
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PubMed Mentions: Fields:
Translation:
HumansCTClinical Trials
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Verapamil-induced atrial fibrillation. N Engl J Med. 1988 Mar 10; 318(10):640-1.
Falk RH, Knowlton AA, Manaker S. PMID: 3344011.
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PubMed Mentions: Fields:
Translation:
Humans
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Digoxin for converting recent-onset atrial fibrillation to sinus rhythm. A randomized, double-blinded trial. Ann Intern Med. 1987 Apr; 106(4):503-6.
Falk RH, Knowlton AA, Bernard SA, Gotlieb NE, Battinelli NJ. PMID: 3548521.
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PubMed Mentions:
47 Fields:
Translation:
HumansCTClinical Trials
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Atypical ventricular tachycardia or motion artifact? Am J Cardiol. 1987 Apr 01; 59(8):924.
Falk RH, Knowlton AA. PMID: 3825957.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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External cardiac pacing during in-hospital cardiac arrest. Am J Cardiol. 1986 Jun 01; 57(15):1295-8.
Knowlton AA, Falk RH. PMID: 3717028.
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PubMed Mentions:
3 Fields:
Translation:
Humans