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Anne A Knowlton, MD

Title(s)Professor, Cardiovascular Medicine
SchoolUniversity of California, Davis
AddressGBSF 6317
CA 95616
Phone530-752-5461
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    Collapse Research 
    Collapse Research Activities and Funding
    Vascular Inflammation and Exosomes as Mediators in Aging and Dementia
    NIH/NIA R01AG056710Mar 15, 2018 - Feb 28, 2023
    Role: Principal Investigator
    Estrogen, Aging and Vascular Inflammation
    VA I01BX000839Oct 1, 2010 - Sep 30, 2014
    Role: Principal Investigator
    Training Program in Basic and Translational Cardiovascular Science
    NIH/NHLBI T32HL086350Dec 1, 2006 - Jun 30, 2023
    Role: Co-Principal Investigator
    HSP60, Inflammation and Cardiovascular Disease
    NIH/NHLBI R01HL079071Dec 1, 2004 - Jun 30, 2015
    Role: Principal Investigator
    Human Cardiomyopathy and HSP60
    NIH/NHLBI R01HL077281Jul 1, 2004 - Jun 30, 2014
    Role: Principal Investigator
    AGING, ESTROGEN, HSPS AND MYOCARDIAL ISCHEMIA
    NIH/NIA R01AG019327May 15, 2001 - Apr 30, 2007
    Role: Principal Investigator
    PHOSPHORYLATION OF HSP 72 AND CARDIAC PROTECTION
    NIH/NHLBI R01HL058515Aug 1, 1997 - Jul 31, 2003
    Role: Principal Investigator
    HSP 70 AND MYOCARDIAL PROTECTION
    NIH/NHLBI R29HL052910Jul 1, 1994 - May 31, 1999
    Role: Principal Investigator
    ROLE OF FATTY ACID BINDING PROTEIN IN CARDIAC ISCHEMIA
    NIH/NHLBI K11HL001853Apr 1, 1987 - Mar 31, 1992
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Impaired proteostasis in senescent vascular endothelial cells: a perspective on estrogen and oxidative stress in the aging vasculature. Am J Physiol Heart Circ Physiol. 2019 02 01; 316(2):H421-H429. Hwang HV, Lin Y, Rebuffatti MN, Tran DT, Lee L, Gomes AV, Li CS, Knowlton AA. PMID: 30499713.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    2. Exosomes and cardiovascular cell-cell communication. Essays Biochem. 2018 05 15; 62(2):193-204. Poe AJ, Knowlton AA. PMID: 29717058.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells. PLoS One. 2018; 13(1):e0190374. Hwang HV, Tran DT, Rebuffatti MN, Li CS, Knowlton AA. PMID: 29315311.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    4. Exosomes as agents of change in the cardiovascular system. J Mol Cell Cardiol. 2017 10; 111:40-50. Poe AJ, Knowlton AA. PMID: 28782514.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    5. Electrotaxis of cardiac progenitor cells, cardiac fibroblasts, and induced pluripotent stem cell-derived cardiac progenitor cells requires serum and is directed via PI3'K pathways. Heart Rhythm. 2017 11; 14(11):1685-1692. Frederich BJ, Timofeyev V, Thai PN, Haddad MJ, Poe AJ, Lau VC, Moshref M, Knowlton AA, Sirish P, Chiamvimonvat N. PMID: 28668623.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    6. Paying for the Tolls: The High Cost of the Innate Immune System for the Cardiac Myocyte. Adv Exp Med Biol. 2017; 1003:17-34. Knowlton AA. PMID: 28667552.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    7. Distinct subcellular mechanisms for the enhancement of the surface membrane expression of SK2 channel by its interacting proteins, a-actinin2 and filamin A. J Physiol. 2017 04 01; 595(7):2271-2284. Zhang Z, Ledford HA, Park S, Wang W, Rafizadeh S, Kim HJ, Xu W, Lu L, Lau VC, Knowlton AA, Zhang XD, Yamoah EN, Chiamvimonvat N. PMID: 27779751.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    8. 11,12-Epoxyecosatrienoic acids mitigate endothelial dysfunction associated with estrogen loss and aging: Role of membrane depolarization. J Mol Cell Cardiol. 2016 05; 94:180-188. Sun C, Simon SI, Foster GA, Radecke CE, Hwang HV, Zhang X, Hammock BD, Chiamvimonvat N, Knowlton AA. PMID: 27079253.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    9. Cardiac Myocyte Exosome Isolation. Methods Mol Biol. 2016; 1448:237-48. Malik ZA, Liu TT, Knowlton AA. PMID: 27317185.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. Mitochondrial Dynamics and Heart Failure. Compr Physiol. 2015 Dec 15; 6(1):507-26. Knowlton AA, Liu TT. PMID: 26756641.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    11. Feedback mechanisms for cardiac-specific microRNAs and cAMP signaling in electrical remodeling. Circ Arrhythm Electrophysiol. 2015 Aug; 8(4):942-50. Myers R, Timofeyev V, Li N, Kim C, Ledford HA, Sirish P, Lau V, Zhang Y, Fayyaz K, Singapuri A, Lopez JE, Knowlton AA, Zhang XD, Chiamvimonvat N. PMID: 25995211.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    12. TLR4 mutation and HSP60-induced cell death in adult mouse cardiac myocytes. Cell Stress Chaperones. 2015 May; 20(3):527-35. Heiserman JP, Chen L, Kim BS, Kim SC, Tran AL, Siebenborn N, Knowlton AA. PMID: 25716072.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    13. Regulation of gene transcription by voltage-gated L-type calcium channel, Cav1.3. J Biol Chem. 2015 Feb 20; 290(8):4663-76. Lu L, Sirish P, Zhang Z, Woltz RL, Li N, Timofeyev V, Knowlton AA, Zhang XD, Yamoah EN, Chiamvimonvat N. PMID: 25538241.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    14. Mitochondrial dynamic changes in health and genetic diseases. Mol Biol Rep. 2014 Nov; 41(11):7053-62. Chen L, Winger AJ, Knowlton AA. PMID: 25103020.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    15. Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca2+-activated K+ (SK2) channel. Proc Natl Acad Sci U S A. 2014 Jul 08; 111(27):9989-94. Rafizadeh S, Zhang Z, Woltz RL, Kim HJ, Myers RE, Lu L, Tuteja D, Singapuri A, Bigdeli AA, Harchache SB, Knowlton AA, Yarov-Yarovoy V, Yamoah EN, Chiamvimonvat N. PMID: 24951510.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    16. Heart failure and mitochondrial dysfunction: the role of mitochondrial fission/fusion abnormalities and new therapeutic strategies. J Cardiovasc Pharmacol. 2014 Mar; 63(3):196-206. Knowlton AA, Chen L, Malik ZA. PMID: 23884159.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    17. Mitochondrial proteome remodeling in ischemic heart failure. Life Sci. 2014 Apr 17; 101(1-2):27-36. Liu T, Chen L, Kim E, Tran D, Phinney BS, Knowlton AA. PMID: 24548633.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    18. Innate immunity and cardiomyocytes in ischemic heart disease. Life Sci. 2014 Mar 28; 100(1):1-8. Lin L, Knowlton AA. PMID: 24486305.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    19. Estrogen and the female heart. Mol Cell Endocrinol. 2014 May 25; 389(1-2):31-9. Knowlton AA, Korzick DH. PMID: 24462775.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    20. Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure. Circ Res. 2014 Jan 17; 114(2):295-306. Yang Y, Guo T, Oda T, Chakraborty A, Chen L, Uchinoumi H, Knowlton AA, Fruen BR, Cornea RL, Meissner G, Bers DM. PMID: 24186966.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    21. Aging, estrogen loss and epoxyeicosatrienoic acids (EETs). PLoS One. 2013; 8(8):e70719. Lee AR, Pechenino AS, Dong H, Hammock BD, Knowlton AA. PMID: 23967089.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    22. Training the translational research teams of the future: UC Davis-HHMI Integrating Medicine into Basic Science program. Clin Transl Sci. 2013 Oct; 6(5):339-46. Knowlton AA, Rainwater JA, Chiamvimonvat N, Bonham AC, Robbins JA, Henderson S, Meyers FJ. PMID: 24127920.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    23. Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes. Cardiovasc Res. 2013 Jun 01; 98(3):391-401. Tian J, Guo X, Liu XM, Liu L, Weng QF, Dong SJ, Knowlton AA, Yuan WJ, Lin L. PMID: 23447644.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    24. Cardiac myocyte exosomes: stability, HSP60, and proteomics. Am J Physiol Heart Circ Physiol. 2013 Apr 01; 304(7):H954-65. Malik ZA, Kott KS, Poe AJ, Kuo T, Chen L, Ferrara KW, Knowlton AA. PMID: 23376832.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    25. Estrogen, Cardiac Protection and Aging. . 2013 Jan 1; 157-174. Anne A. Knowlton. .
      View in: Publisher Site   Mentions:
    26. OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability. J Am Heart Assoc. 2012 Oct; 1(5):e003012. Chen L, Liu T, Tran A, Lu X, Tomilov AA, Davies V, Cortopassi G, Chiamvimonvat N, Bers DM, Votruba M, Knowlton AA. PMID: 23316298.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    27. Improved Metabolic Control in Diabetes, HSP60, and Proinflammatory Mediators. Autoimmune Dis. 2012; 2012:346501. Blasi C, Kim E, Knowlton AA. PMID: 22924123.
      View in: PubMed   Mentions:
    28. IRF-1 and miRNA126 modulate VCAM-1 expression in response to a high-fat meal. Circ Res. 2012 Sep 28; 111(8):1054-64. Sun C, Alkhoury K, Wang YI, Foster GA, Radecke CE, Tam K, Edwards CM, Facciotti MT, Armstrong EJ, Knowlton AA, Newman JW, Passerini AG, Simon SI. PMID: 22874466.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    29. Rapid activation of nuclear factor ?B by 17ß-estradiol and selective estrogen receptor modulators: pathways mediating cellular protection. Shock. 2012 Aug; 38(2):128-36. Stice JP, Mbai FN, Chen L, Knowlton AA. PMID: 22683727.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    30. The aging heart and estrogen. Aging Health. 2012 Apr 1; 8(2):163-166. Anne A Knowlton. .
      View in: Publisher Site   Mentions:
    31. Estrogen and the cardiovascular system. Pharmacol Ther. 2012 Jul; 135(1):54-70. Knowlton AA, Lee AR. PMID: 22484805.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    32. Regulating a uniter: control of mitofusin 2 expression. Cardiovasc Res. 2012 Apr 01; 94(1):6-7. Knowlton AA, Chen L. PMID: 22362816.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    33. Hyperamylinemia contributes to cardiac dysfunction in obesity and diabetes: a study in humans and rats. Circ Res. 2012 Feb 17; 110(4):598-608. Despa S, Margulies KB, Chen L, Knowlton AA, Havel PJ, Taegtmeyer H, Bers DM, Despa F. PMID: 22275486.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    34. Estrogen and cardiovascular disease: aging and estrogen loss at the heart of the matter? Future Cardiol. 2012 Jan; 8(1):9-12. Knowlton AA. PMID: 22185441.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    35. Mitochondrial dynamics in heart failure. Congest Heart Fail. 2011 Nov-Dec; 17(6):257-61. Chen L, Knowlton AA. PMID: 22848903.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    36. Tocotrienols confer resistance to ischemia in hypercholesterolemic hearts: insight with genomics. Mol Cell Biochem. 2012 Jan; 360(1-2):35-45. Das S, Mukherjee S, Lekli I, Gurusamy N, Bardhan J, Raychoudhury U, Chakravarty R, Banerji S, Knowlton AA, Das DK. PMID: 21918828.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    37. Impact of aging vs. estrogen loss on cardiac gene expression: estrogen replacement and inflammation. Physiol Genomics. 2011 Sep 22; 43(18):1065-73. Pechenino AS, Lin L, Mbai FN, Lee AR, He XM, Stallone JN, Knowlton AA. PMID: 21750230.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    38. The heat shock paradox and cardiac myocytes: role of heat shock factor. Shock. 2011 May; 35(5):478-84. Kobba S, Kim SC, Chen L, Kim E, Tran AL, Knuefermann P, Knowlton AA. PMID: 21192280.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    39. 17ß-Estradiol, aging, inflammation, and the stress response in the female heart. Endocrinology. 2011 Apr; 152(4):1589-98. Stice JP, Chen L, Kim SC, Jung JS, Tran AL, Liu TT, Knowlton AA. PMID: 21303943.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    40. CD11c/CD18 expression is upregulated on blood monocytes during hypertriglyceridemia and enhances adhesion to vascular cell adhesion molecule-1. Arterioscler Thromb Vasc Biol. 2011 Jan; 31(1):160-6. Gower RM, Wu H, Foster GA, Devaraj S, Jialal I, Ballantyne CM, Knowlton AA, Simon SI. PMID: 21030716.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    41. Cardiac small conductance Ca2+-activated K+ channel subunits form heteromultimers via the coiled-coil domains in the C termini of the channels. Circ Res. 2010 Oct 01; 107(7):851-9. Tuteja D, Rafizadeh S, Timofeyev V, Wang S, Zhang Z, Li N, Mateo RK, Singapuri A, Young JN, Knowlton AA, Chiamvimonvat N. PMID: 20689065.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    42. Mitochondria and heart failure: new insights into an energetic problem. Minerva Cardioangiol. 2010 Apr; 58(2):213-29. Chen L, Knowlton AA. PMID: 20440251.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    43. Neutral sphingomyelinase 2 (nSMase2) is a phosphoprotein regulated by calcineurin (PP2B). J Biol Chem. 2010 Apr 02; 285(14):10213-22. Filosto S, Fry W, Knowlton AA, Goldkorn T. PMID: 20106976.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    44. Regulation of heat shock protein 60 and 72 expression in the failing heart. J Mol Cell Cardiol. 2010 Feb; 48(2):360-6. Wang Y, Chen L, Hagiwara N, Knowlton AA. PMID: 19945465.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    45. Extracellular heat shock protein 60, cardiac myocytes, and apoptosis. Circ Res. 2009 Dec 04; 105(12):1186-95. Kim SC, Stice JP, Chen L, Jung JS, Gupta S, Wang Y, Baumgarten G, Trial J, Knowlton AA. PMID: 19875724.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    46. Mitochondrial OPA1, apoptosis, and heart failure. Cardiovasc Res. 2009 Oct 01; 84(1):91-9. Chen L, Gong Q, Stice JP, Knowlton AA. PMID: 19493956.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    47. Estrogen, aging and the cardiovascular system. Future Cardiol. 2009 Jan; 5(1):93-103. Stice JP, Lee JS, Pechenino AS, Knowlton AA. PMID: 19371207.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    48. Role of aging versus the loss of estrogens in the reduction in vascular function in female rats. Endocrinology. 2009 Jan; 150(1):212-9. Stice JP, Eiserich JP, Knowlton AA. PMID: 18787021.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    49. Effects of dietary decosahexaenoic acid (DHA) on eNOS in human coronary artery endothelial cells. J Cardiovasc Pharmacol Ther. 2008 Dec; 13(4):261-8. Stebbins CL, Stice JP, Hart CM, Mbai FN, Knowlton AA. PMID: 18682551.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    50. Estrogen, NFkappaB, and the heat shock response. Mol Med. 2008 Jul-Aug; 14(7-8):517-27. Stice JP, Knowlton AA. PMID: 18431462.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    51. Heat-shock protein 60 and cardiovascular disease: a paradoxical role. Future Cardiol. 2008 Mar; 4(2):151-61. Knowlton AA, Srivatsa U. PMID: 19804293.
      View in: PubMed   Mentions: 8     Fields:    
    52. Effect of ovariectomy on cardiac gene expression: inflammation and changes in SOCS gene expression. Physiol Genomics. 2008 Jan 17; 32(2):254-63. Hamilton KL, Lin L, Wang Y, Knowlton AA. PMID: 17986523.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    53. HSP60 in heart failure: abnormal distribution and role in cardiac myocyte apoptosis. Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2238-47. Lin L, Kim SC, Wang Y, Gupta S, Davis B, Simon SI, Torre-Amione G, Knowlton AA. PMID: 17675567.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    54. Toll-like receptor 4 deficiency: smaller infarcts, but no gain in function. BMC Physiol. 2007 Jun 25; 7:5. Kim SC, Ghanem A, Stapel H, Tiemann K, Knuefermann P, Hoeft A, Meyer R, Grohé C, Knowlton AA, Baumgarten G. PMID: 17592640.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    55. HSP60 trafficking in adult cardiac myocytes: role of the exosomal pathway. Am J Physiol Heart Circ Physiol. 2007 Jun; 292(6):H3052-6. Gupta S, Knowlton AA. PMID: 17307989.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    56. Triglyceride-rich lipoproteins prime aortic endothelium for an enhanced inflammatory response to tumor necrosis factor-alpha. Circ Res. 2007 Feb 16; 100(3):381-90. Ting HJ, Stice JP, Schaff UY, Hui DY, Rutledge JC, Knowlton AA, Passerini AG, Simon SI. PMID: 17234968.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    57. Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2. Circ Res. 2007 Jan 05; 100(1):112-20. Lu L, Zhang Q, Timofeyev V, Zhang Z, Young JN, Shin HS, Knowlton AA, Chiamvimonvat N. PMID: 17110593.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    58. Life, death, the unfolded protein response and apoptosis. Cardiovasc Res. 2007 Jan 01; 73(1):1-2. Knowlton AA. PMID: 17145049.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    59. Toll-like receptor 4, nitric oxide, and myocardial depression in endotoxemia. Shock. 2006 Jan; 25(1):43-9. Baumgarten G, Knuefermann P, Schuhmacher G, Vervölgyi V, von Rappard J, Dreiner U, Fink K, Djoufack C, Hoeft A, Grohé C, Knowlton AA, Meyer R. PMID: 16369185.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    60. NFkappaB, heat shock proteins, HSF-1, and inflammation. Cardiovasc Res. 2006 Jan; 69(1):7-8. Knowlton AA. PMID: 16337613.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    61. Effect of mutation of amino acids 246-251 (KRKHKK) in HSP72 on protein synthesis and recovery from hypoxic injury. Am J Physiol Heart Circ Physiol. 2005 Dec; 289(6):H2519-25. Voss MR, Gupta S, Stice JP, Baumgarten G, Lu L, Tristan JM, Knowlton AA. PMID: 16100242.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    62. Gender differences in cardiovascular disease: The effects of estrogen. Drug Discovery Today Disease Mechanisms. 2005 Mar 1; 2(1):65-70. Fiona N. Mbai, Karyn L. Hamilton, Anne A. Knowlton. .
      View in: Publisher Site   Mentions:
    63. Aging, ischemia and the heart. J Mol Cell Cardiol. 2005 Feb; 38(2):241-4. Mbai FN, Knowlton AA. PMID: 15698830.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    64. HSP60, Bax, apoptosis and the heart. J Cell Mol Med. 2005 Jan-Mar; 9(1):51-8. Gupta S, Knowlton AA. PMID: 15784164.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    65. Estrogen, heat shock proteins, and NFkappaB in human vascular endothelium. Arterioscler Thromb Vasc Biol. 2004 Sep; 24(9):1628-33. Hamilton KL, Mbai FN, Gupta S, Knowlton AA. PMID: 15231513.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    66. Inflammation and ischemia: macrophages activated by fibronectin fragments enhance the survival of injured cardiac myocytes. Exp Biol Med (Maywood). 2004 Jun; 229(6):538-45. Trial J, Rossen RD, Rubio J, Knowlton AA. PMID: 15169973.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    67. Estrogen and regulation of heat shock protein expression in female cardiomyocytes: cross-talk with NF kappa B signaling. J Mol Cell Cardiol. 2004 Apr; 36(4):577-84. Hamilton KL, Gupta S, Knowlton AA. PMID: 15081317.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    68. Glutathione S-transferase pi is upregulated in the stromal compartment of hormone independent prostate cancer. Prostate. 2003 Jul 01; 56(2):98-105. Li M, Ittmann MM, Rowley DR, Knowlton AA, Vaid AK, Epner DE. PMID: 12746833.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    69. Gender differences in the expression of heat shock proteins: the effect of estrogen. Am J Physiol Heart Circ Physiol. 2003 Aug; 285(2):H687-92. Voss MR, Stallone JN, Li M, Cornelussen RN, Knuefermann P, Knowlton AA. PMID: 12714326.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    70. Complications of inappropriate use of spironolactone in heart failure: when an old medicine spirals out of new guidelines. J Am Coll Cardiol. 2003 Jan 15; 41(2):211-4. Bozkurt B, Agoston I, Knowlton AA. PMID: 12535810.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCTClinical Trials
    71. HSP60, Bax, and cardiac apoptosis. Cardiovasc Toxicol. 2003; 3(3):263-8. Knowlton AA, Gupta S. PMID: 14555791.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    72. Cytosolic heat shock protein 60, hypoxia, and apoptosis. Circulation. 2002 Nov 19; 106(21):2727-33. Gupta S, Knowlton AA. PMID: 12438300.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    73. Heme-oxygenase-1: versatile sentinel against injury. J Mol Cell Cardiol. 2002 Oct; 34(10):1297-1300. Cornelussen RN, Knowlton AA. PMID: 12392988.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    74. Cytosolic heat shock protein 60, apoptosis, and myocardial injury. Circulation. 2002 Jun 18; 105(24):2899-904. Kirchhoff SR, Gupta S, Knowlton AA. PMID: 12070120.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    75. Hsp72 expression enhances survival in adenosine triphosphate-depleted renal epithelial cells. Cell Stress Chaperones. 2002 Apr; 7(2):137-45. Wang YH, Knowlton AA, Li FH, Borkan SC. PMID: 12380681.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    76. Presence of heat shock protein 72 in cardiomyocytes after heat stress. Circulation. 2001 Nov 27; 104(22):E123. Cornelussen RN, van Nieuwenhoven FA, Snoeckx LH, Knowlton AA. PMID: 11723036.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    77. Congestive heart failure and outpatient risk of venous thromboembolism: a retrospective, case-control study. J Clin Epidemiol. 2001 Aug; 54(8):810-6. Howell MD, Geraci JM, Knowlton AA. PMID: 11470390.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    78. Regulation of prostaglandin A1-induced heat shock protein expression in isolated cardiomyocytes. J Mol Cell Cardiol. 2001 Aug; 33(8):1447-54. Cornelussen RN, Gupta S, Knowlton AA. PMID: 11448133.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    79. Activation of heat-shock factor by stretch-activated channels in rat hearts. Circulation. 2001 Jul 10; 104(2):209-14. Chang J, Wasser JS, Cornelussen RN, Knowlton AA. PMID: 11447088.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    80. Mutation of amino acids 566-572 (KKKVLDK) inhibits nuclear accumulation of heat shock protein 72 after heat shock. J Mol Cell Cardiol. 2001 Jan; 33(1):49-55. Knowlton AA. PMID: 11133222.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    81. Activation of the heat shock response: relationship to energy metabolites. A (31)P NMR study in rat hearts. Am J Physiol Heart Circ Physiol. 2001 Jan; 280(1):H426-33. Chang J, Knowlton AA, Xu F, Wasser JS. PMID: 11123260.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    82. Heat-shock factor-1, steroid hormones, and regulation of heat-shock protein expression in the heart. Am J Physiol Heart Circ Physiol. 2001 Jan; 280(1):H455-64. Knowlton AA, Sun L. PMID: 11123263.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    83. Spironolactone for heart failure: spiraling out of control. Chest. 2000 Dec; 118(6):1522-3. Geraci JM, Knowlton AA. PMID: 11115427.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    84. Phosphorylation at tyrosine-524 influences nuclear accumulation of HSP72 with heat stress. Am J Physiol Heart Circ Physiol. 2000 Jun; 278(6):H2143-9. Knowlton AA, Grenier M, Kirchhoff SR, Salfity M. PMID: 10843914.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    85. Activation of HSF and selective increase in heat-shock proteins by acute dexamethasone treatment. Am J Physiol Heart Circ Physiol. 2000 Apr; 278(4):H1091-7. Sun L, Chang J, Kirchhoff SR, Knowlton AA. PMID: 10749702.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    86. Expression of heat shock proteins in turtle and mammal hearts: relationship to anoxia tolerance. Am J Physiol Regul Integr Comp Physiol. 2000 Jan; 278(1):R209-14. Chang J, Knowlton AA, Wasser JS. PMID: 10644641.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    87. Prior heat stress inhibits apoptosis in adenosine triphosphate-depleted renal tubular cells. Kidney Int. 1999 Jun; 55(6):2224-35. Wang Y, Knowlton AA, Christensen TG, Shih T, Borkan SC. PMID: 10354271.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    88. Mutation of amino acids 246-251 alters nuclear accumulation of human heat shock protein (HSP) 72 with stress, but does not reduce viability. J Mol Cell Cardiol. 1999 Mar; 31(3):523-32. Knowlton AA. PMID: 10198184.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    89. Tumor necrosis factor-alpha confers resistance to hypoxic injury in the adult mammalian cardiac myocyte. Circulation. 1998 Apr 14; 97(14):1392-400. Nakano M, Knowlton AA, Dibbs Z, Mann DL. PMID: 9577951.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    90. Differential expression of heat shock proteins in normal and failing human hearts. J Mol Cell Cardiol. 1998 Apr; 30(4):811-8. Knowlton AA, Kapadia S, Torre-Amione G, Durand JB, Bies R, Young J, Mann DL. PMID: 9602430.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    91. Blocking the endogenous increase in HSP 72 increases susceptibility to hypoxia and reoxygenation in isolated adult feline cardiocytes. Circulation. 1997 Mar 18; 95(6):1523-31. Nakano M, Mann DL, Knowlton AA. PMID: 9118521.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    92. Tumor necrosis factor-alpha-induced expression of heat shock protein 72 in adult feline cardiac myocytes. Am J Physiol. 1996 Apr; 270(4 Pt 2):H1231-9. Nakano M, Knowlton AA, Yokoyama T, Lesslauer W, Mann DL. PMID: 8967361.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    93. The role of heat shock proteins in the heart. J Mol Cell Cardiol. 1995 Jan; 27(1):121-31. Knowlton AA. PMID: 7760337.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    94. Current concepts in transcription, translation, and the regulation of gene expression. A primer for the clinician. Chest. 1995 Jan; 107(1):241-8. Knowlton AA. PMID: 7813285.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    95. Late preconditioning against myocardial stunning. An endogenous protective mechanism that confers resistance to postischemic dysfunction 24 h after brief ischemia in conscious pigs. J Clin Invest. 1995 Jan; 95(1):388-403. Sun JZ, Tang XL, Knowlton AA, Park SW, Qiu Y, Bolli R. PMID: 7814639.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    96. Heat-shock proteins, stress, and the heart. Ann N Y Acad Sci. 1994 Jun 17; 723:128-37. Knowlton AA. PMID: 8030860.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    97. Rapid expression of fibronectin in the rabbit heart after myocardial infarction with and without reperfusion. J Clin Invest. 1992 Apr; 89(4):1060-8. Knowlton AA, Connelly CM, Romo GM, Mamuya W, Apstein CS, Brecher P. PMID: 1556175.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    98. A single myocardial stretch or decreased systolic fiber shortening stimulates the expression of heat shock protein 70 in the isolated, erythrocyte-perfused rabbit heart. J Clin Invest. 1991 Dec; 88(6):2018-25. Knowlton AA, Eberli FR, Brecher P, Romo GM, Owen A, Apstein CS. PMID: 1752959.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    99. Rapid expression of heat shock protein in the rabbit after brief cardiac ischemia. J Clin Invest. 1991 Jan; 87(1):139-47. Knowlton AA, Brecher P, Apstein CS. PMID: 1985091.
      View in: PubMed   Mentions: 45     Fields:    Translation:Animals
    100. Paradoxical increase in heart rate before conversion to sinus rhythm in patients with recent-onset atrial fibrillation. Am J Cardiol. 1990 Apr 01; 65(13):930-2. Knowlton AA, Falk RH. PMID: 2321547.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    101. Rabbit heart fatty acid-binding protein. Isolation, characterization, and application of a monoclonal antibody. Circ Res. 1989 Oct; 65(4):981-8. Knowlton AA, Burrier RE, Brecher P. PMID: 2791232.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    102. Leakage of heart fatty acid binding protein with ischemia and reperfusion in the rat. J Mol Cell Cardiol. 1989 Jun; 21(6):577-83. Knowlton AA, Apstein CS, Saouf R, Brecher P. PMID: 2778809.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    103. Acute rhabdomyolysis associated with cocaine intoxication. N Engl J Med. 1989 Mar 09; 320(10):667-8. PMID: 2918879.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    104. Purulent pericarditis and ventricular pseudoaneurysm in an intravenous drug abuser. Am Heart J. 1988 Dec; 116(6 Pt 1):1635-7. Wiegers SE, Plehn JF, Rajail-Khorasani A, Knowlton AA. PMID: 3195447.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    105. The effect of propranolol and verapamil on external pacing threshold: a placebo-controlled study. Pacing Clin Electrophysiol. 1988 Oct; 11(10):1439-43. Falk RH, Knowlton AA, Battinelli NJ. PMID: 2462221.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    106. Verapamil-induced atrial fibrillation. N Engl J Med. 1988 Mar 10; 318(10):640-1. Falk RH, Knowlton AA, Manaker S. PMID: 3344011.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    107. Digoxin for converting recent-onset atrial fibrillation to sinus rhythm. A randomized, double-blinded trial. Ann Intern Med. 1987 Apr; 106(4):503-6. Falk RH, Knowlton AA, Bernard SA, Gotlieb NE, Battinelli NJ. PMID: 3548521.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCTClinical Trials
    108. Atypical ventricular tachycardia or motion artifact? Am J Cardiol. 1987 Apr 01; 59(8):924. Falk RH, Knowlton AA. PMID: 3825957.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    109. External cardiac pacing during in-hospital cardiac arrest. Am J Cardiol. 1986 Jun 01; 57(15):1295-8. Knowlton AA, Falk RH. PMID: 3717028.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
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