Anne A. Knowlton

InstitutionUniversity of California Davis
AddressGBSF 6317
CA 95616
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    Collapse Research 
    Collapse Research Activities and Funding
    Vascular Inflammation and Exosomes as Mediators in Aging and Dementia
    NIH/NIA R01AG056710Mar 15, 2018 - Feb 28, 2023
    Role: Principal Investigator
    Estrogen, Aging and Vascular Inflammation
    VA I01BX000839Oct 1, 2010 - Sep 30, 2014
    Role: Principal Investigator
    Training Program in Basic and Translational Cardiovascular Science
    NIH/NHLBI T32HL086350Dec 1, 2006 - Jun 30, 2023
    Role: Co-Principal Investigator
    HSP60, Inflammation and Cardiovascular Disease
    NIH/NHLBI R01HL079071Dec 1, 2004 - Jun 30, 2015
    Role: Principal Investigator
    Human Cardiomyopathy and HSP60
    NIH/NHLBI R01HL077281Jul 1, 2004 - Jun 30, 2014
    Role: Principal Investigator
    NIH/NIA R01AG019327May 15, 2001 - Apr 30, 2007
    Role: Principal Investigator
    NIH/NHLBI R01HL058515Aug 1, 1997 - Jul 31, 2003
    Role: Principal Investigator
    NIH/NHLBI R29HL052910Jul 1, 1994 - May 31, 1999
    Role: Principal Investigator
    NIH/NHLBI K11HL001853Apr 1, 1987 - Mar 31, 1992
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Poe AJ, Knowlton A. Exosomes and cardiovascular cell-cell communication. Essays Biochem. 2018 May 15; 62(2):193-204. PMID: 29717058.
      View in: PubMed
    2. Hwang HV, Tran DT, Rebuffatti MN, Li CS, Knowlton A. Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells. PLoS One. 2018; 13(1):e0190374. PMID: 29315311.
      View in: PubMed
    3. Frederich BJ, Timofeyev V, Thai PN, Haddad MJ, Poe AJ, Lau VC, Moshref M, Knowlton A, Sirish P, Chiamvimonvat N. Electrotaxis of cardiac progenitor cells, cardiac fibroblasts, and induced pluripotent stem cell-derived cardiac progenitor cells requires serum and is directed via PI3'K pathways. Heart Rhythm. 2017 Nov; 14(11):1685-1692. PMID: 28668623.
      View in: PubMed
    4. Knowlton A. Paying for the Tolls: The High Cost of the Innate Immune System for the Cardiac Myocyte. Adv Exp Med Biol. 2017; 1003:17-34. PMID: 28667552.
      View in: PubMed
    5. Zhang Z, Ledford HA, Park S, Wang W, Rafizadeh S, Kim HJ, Xu W, Lu L, Lau VC, Knowlton A, Zhang XD, Yamoah EN, Chiamvimonvat N. Distinct subcellular mechanisms for the enhancement of the surface membrane expression of SK2 channel by its interacting proteins, a-actinin2 and filamin A. J Physiol. 2017 Apr 01; 595(7):2271-2284. PMID: 27779751.
      View in: PubMed
    6. Sun C, Simon SI, Foster GA, Radecke CE, Hwang HV, Zhang X, Hammock BD, Chiamvimonvat N, Knowlton A. 11,12-Epoxyecosatrienoic acids mitigate endothelial dysfunction associated with estrogen loss and aging: Role of membrane depolarization. J Mol Cell Cardiol. 2016 05; 94:180-188. PMID: 27079253.
      View in: PubMed
    7. Malik ZA, Liu TT, Knowlton A. Cardiac Myocyte Exosome Isolation. Methods Mol Biol. 2016; 1448:237-48. PMID: 27317185.
      View in: PubMed
    8. Myers R, Timofeyev V, Li N, Kim C, Ledford HA, Sirish P, Lau V, Zhang Y, Fayyaz K, Singapuri A, Lopez JE, Knowlton A, Zhang XD, Chiamvimonvat N. Feedback mechanisms for cardiac-specific microRNAs and cAMP signaling in electrical remodeling. Circ Arrhythm Electrophysiol. 2015 Aug; 8(4):942-50. PMID: 25995211; PMCID: PMC4545299.
    9. Lu L, Sirish P, Zhang Z, Woltz RL, Li N, Timofeyev V, Knowlton A, Zhang XD, Yamoah EN, Chiamvimonvat N. Regulation of gene transcription by voltage-gated L-type calcium channel, Cav1.3. J Biol Chem. 2015 Feb 20; 290(8):4663-76. PMID: 25538241; PMCID: PMC4335206.
    10. Chen L, Winger AJ, Knowlton A. Mitochondrial dynamic changes in health and genetic diseases. Mol Biol Rep. 2014 Nov; 41(11):7053-62. PMID: 25103020.
      View in: PubMed
    11. Knowlton A, Chen L, Malik ZA. Heart failure and mitochondrial dysfunction: the role of mitochondrial fission/fusion abnormalities and new therapeutic strategies. J Cardiovasc Pharmacol. 2014 Mar; 63(3):196-206. PMID: 23884159; PMCID: PMC4088994.
    12. Liu T, Chen L, Kim E, Tran D, Phinney BS, Knowlton A. Mitochondrial proteome remodeling in ischemic heart failure. Life Sci. 2014 Apr 17; 101(1-2):27-36. PMID: 24548633; PMCID: PMC4075482.
    13. Lin L, Knowlton A. Innate immunity and cardiomyocytes in ischemic heart disease. Life Sci. 2014 Mar 28; 100(1):1-8. PMID: 24486305; PMCID: PMC3970925.
    14. Knowlton A, Korzick DH. Estrogen and the female heart. Mol Cell Endocrinol. 2014 May 25; 389(1-2):31-9. PMID: 24462775.
      View in: PubMed
    15. Yang Y, Guo T, Oda T, Chakraborty A, Chen L, Uchinoumi H, Knowlton A, Fruen BR, Cornea RL, Meissner G, Bers DM. Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure. Circ Res. 2014 Jan 17; 114(2):295-306. PMID: 24186966; PMCID: PMC4004530.
    16. Lee AR, Pechenino AS, Dong H, Hammock BD, Knowlton A. Aging, estrogen loss and epoxyeicosatrienoic acids (EETs). PLoS One. 2013; 8(8):e70719. PMID: 23967089; PMCID: PMC3742755.
    17. Knowlton A, Rainwater JA, Chiamvimonvat N, Bonham AC, Robbins JA, Henderson S, Meyers FJ. Training the translational research teams of the future: UC Davis-HHMI Integrating Medicine into Basic Science program. Clin Transl Sci. 2013 Oct; 6(5):339-46. PMID: 24127920; PMCID: PMC3801412.
    18. Tian J, Guo X, Liu XM, Liu L, Weng QF, Dong SJ, Knowlton A, Yuan WJ, Lin L. Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes. Cardiovasc Res. 2013 Jun 01; 98(3):391-401. PMID: 23447644.
      View in: PubMed
    19. Chen L, Liu T, Tran A, Lu X, Tomilov AA, Davies V, Cortopassi G, Chiamvimonvat N, Bers DM, Votruba M, Knowlton A. OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability. J Am Heart Assoc. 2012 Oct; 1(5):e003012. PMID: 23316298; PMCID: PMC3541627.
    20. Sun C, Alkhoury K, Wang YI, Foster GA, Radecke CE, Tam K, Edwards CM, Facciotti MT, Armstrong EJ, Knowlton A, Newman JW, Passerini AG, Simon SI. IRF-1 and miRNA126 modulate VCAM-1 expression in response to a high-fat meal. Circ Res. 2012 Sep 28; 111(8):1054-64. PMID: 22874466; PMCID: PMC3810165.
    21. Stice JP, Mbai FN, Chen L, Knowlton A. Rapid activation of nuclear factor ?B by 17ß-estradiol and selective estrogen receptor modulators: pathways mediating cellular protection. Shock. 2012 Aug; 38(2):128-36. PMID: 22683727; PMCID: PMC3401555.
    22. Knowlton A, Lee AR. Estrogen and the cardiovascular system. Pharmacol Ther. 2012 Jul; 135(1):54-70. PMID: 22484805.
      View in: PubMed
    23. Despa S, Margulies KB, Chen L, Knowlton A, Havel PJ, Taegtmeyer H, Bers DM, Despa F. Hyperamylinemia contributes to cardiac dysfunction in obesity and diabetes: a study in humans and rats. Circ Res. 2012 Feb 17; 110(4):598-608. PMID: 22275486; PMCID: PMC3303627.
    24. Knowlton A. Estrogen and cardiovascular disease: aging and estrogen loss at the heart of the matter? Future Cardiol. 2012 Jan; 8(1):9-12. PMID: 22185441.
      View in: PubMed
    25. Das S, Mukherjee S, Lekli I, Gurusamy N, Bardhan J, Raychoudhury U, Chakravarty R, Banerji S, Knowlton A, Das DK. Tocotrienols confer resistance to ischemia in hypercholesterolemic hearts: insight with genomics. Mol Cell Biochem. 2012 Jan; 360(1-2):35-45. PMID: 21918828.
      View in: PubMed
    26. Kobba S, Kim SC, Chen L, Kim E, Tran AL, Knuefermann P, Knowlton A. The heat shock paradox and cardiac myocytes: role of heat shock factor. Shock. 2011 May; 35(5):478-84. PMID: 21192280; PMCID: PMC3435103.
    27. Stice JP, Chen L, Kim SC, Jung JS, Tran AL, Liu TT, Knowlton A. 17ß-Estradiol, aging, inflammation, and the stress response in the female heart. Endocrinology. 2011 Apr; 152(4):1589-98. PMID: 21303943; PMCID: PMC3060632.
    28. Gower RM, Wu H, Foster GA, Devaraj S, Jialal I, Ballantyne CM, Knowlton A, Simon SI. CD11c/CD18 expression is upregulated on blood monocytes during hypertriglyceridemia and enhances adhesion to vascular cell adhesion molecule-1. Arterioscler Thromb Vasc Biol. 2011 Jan; 31(1):160-6. PMID: 21030716; PMCID: PMC3038249.
    29. Tuteja D, Rafizadeh S, Timofeyev V, Wang S, Zhang Z, Li N, Mateo RK, Singapuri A, Young JN, Knowlton A, Chiamvimonvat N. Cardiac small conductance Ca2+-activated K+ channel subunits form heteromultimers via the coiled-coil domains in the C termini of the channels. Circ Res. 2010 Oct 01; 107(7):851-9. PMID: 20689065; PMCID: PMC3732376.
    30. Filosto S, Fry W, Knowlton A, Goldkorn T. Neutral sphingomyelinase 2 (nSMase2) is a phosphoprotein regulated by calcineurin (PP2B). J Biol Chem. 2010 Apr 02; 285(14):10213-22. PMID: 20106976; PMCID: PMC2856226.
    31. Kim SC, Stice JP, Chen L, Jung JS, Gupta S, Wang Y, Baumgarten G, Trial J, Knowlton A. Extracellular heat shock protein 60, cardiac myocytes, and apoptosis. Circ Res. 2009 Dec 04; 105(12):1186-95. PMID: 19875724; PMCID: PMC2949276.
    32. Chen L, Gong Q, Stice JP, Knowlton A. Mitochondrial OPA1, apoptosis, and heart failure. Cardiovasc Res. 2009 Oct 01; 84(1):91-9. PMID: 19493956; PMCID: PMC2741347.
    33. Stice JP, Lee JS, Pechenino AS, Knowlton A. Estrogen, aging and the cardiovascular system. Future Cardiol. 2009 Jan; 5(1):93-103. PMID: 19371207; PMCID: PMC3972065.
    34. Stebbins CL, Stice JP, Hart CM, Mbai FN, Knowlton A. Effects of dietary decosahexaenoic acid (DHA) on eNOS in human coronary artery endothelial cells. J Cardiovasc Pharmacol Ther. 2008 Dec; 13(4):261-8. PMID: 18682551; PMCID: PMC4437661.
    35. Stice JP, Knowlton A. Estrogen, NFkappaB, and the heat shock response. Mol Med. 2008 Jul-Aug; 14(7-8):517-27. PMID: 18431462; PMCID: PMC2323333.
    36. Knowlton A, Srivatsa U. Heat-shock protein 60 and cardiovascular disease: a paradoxical role. Future Cardiol. 2008 Mar; 4(2):151-61. PMID: 19804293.
      View in: PubMed
    37. Hamilton KL, Lin L, Wang Y, Knowlton A. Effect of ovariectomy on cardiac gene expression: inflammation and changes in SOCS gene expression. Physiol Genomics. 2008 Jan 17; 32(2):254-63. PMID: 17986523.
      View in: PubMed
    38. Ting HJ, Stice JP, Schaff UY, Hui DY, Rutledge JC, Knowlton A, Passerini AG, Simon SI. Triglyceride-rich lipoproteins prime aortic endothelium for an enhanced inflammatory response to tumor necrosis factor-alpha. Circ Res. 2007 Feb 16; 100(3):381-90. PMID: 17234968.
      View in: PubMed
    39. Lu L, Zhang Q, Timofeyev V, Zhang Z, Young JN, Shin HS, Knowlton A, Chiamvimonvat N. Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2. Circ Res. 2007 Jan 05; 100(1):112-20. PMID: 17110593.
      View in: PubMed
    40. Knowlton A. Life, death, the unfolded protein response and apoptosis. Cardiovasc Res. 2007 Jan 01; 73(1):1-2. PMID: 17145049.
      View in: PubMed
    41. Trial J, Rossen RD, Rubio J, Knowlton A. Inflammation and ischemia: macrophages activated by fibronectin fragments enhance the survival of injured cardiac myocytes. Exp Biol Med (Maywood). 2004 Jun; 229(6):538-45. PMID: 15169973; PMCID: PMC4773909.
    42. Knowlton A, Gupta S. HSP60, Bax, and cardiac apoptosis. Cardiovasc Toxicol. 2003; 3(3):263-8. PMID: 14555791.
      View in: PubMed