Javier E Lopez

Title(s)Professor, MED: Int Med Cardiology (Sac)
SchoolSchool of Medicine
ORCID ORCID Icon0000-0001-7276-6628 Additional info
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    Other Positions
    Title(s)Professor in Residence, MED: Int Med Cardiology (Sac)


    Collapse Biography 
    Collapse education and training
    Temple University School of Medicine, Philadelphia, PAMD06/1999Medicine
    University of Texas Southwestern, Dallas, TX06/2002Internal Medicine Residency
    University of California San Francisco, San Francisco, CA06/2007Cardiovascular Research
    University of California Davis, Davis, CA06/2010Clinical Cardiology Fellowship
    University of California Davis, Davis, CAMAS06/2012Clinical Translational Science

    Collapse Research 
    Collapse research activities and funding
    A prospective multiethnic HFpEF cohort from California's Central Valley
    NIH U01HL160274Sep 10, 2021 - Jun 30, 2026
    Role: Co-Principal Investigator
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. EXPRESS: Single-tracer [18F]FDG PET quantification of blood-brain barrier permeability and cerebral blood flow: Validation using dual-tracer PET. J Cereb Blood Flow Metab. 2026 May 31; 271678X261458293. Chung KJ, Jones T, Abdelhafez YG, Spencer BA, Lopez JE, Nardo L, Chaudhari AJ, Fan AP, Badawi RD, Cherry S, Wang G. PMID: 42219949.
      View in: PubMed   Mentions:    Fields:    
    2. Deep Learning Echocardiographic Trajectories of Heart Failure With Preserved Ejection Fraction: A Retrospective Cohort Study. JACC Adv. 2026 Apr; 5(4):102659. Romero E, Oliveira da Silva H, Sirish P, Lopez JE, Chiamvimonvat N, Liem DA, Cadeiras M. PMID: 41855744; PMCID: PMC13010401.
      View in: PubMed   Mentions:
    3. VillageNet: Graph-based, Easily-interpretable, Unsupervised Clustering for Broad Biomedical Applications. ArXiv. 2026 Feb 23. Ballal A, DePaul GA, Datta E, Hatano A, Carlsson E, Chen-Izu Y, López JE, Izu LT. PMID: 41810032; PMCID: PMC12970389.
      View in: PubMed   Mentions:
    4. Rationale and Design of the HeartShare/AMP-HF Deep Phenotyping Study to Improve Understanding of Heart Failure With Preserved Ejection Fraction. JACC Heart Fail. 2025 Dec; 13(12):102714. Borlaug BA, Chirinos JA, Lewis GD, Redfield MM, Bertoni AG, Cadeiras M, Chiamvimonvat N, Desai AS, Givertz MM, Kass DA, Khan SS, Kitzman DW, López JE, Rasmussen-Torvik LJ, Sharma K, Solomon SD, Goodpaster B, Sparks L, Olgin J, Arnaout R, Mylavarapu U, Alagna L, Luo Y, Wong R, Desvigne-Nickens P, Tinsley E, Kamphaus TN, Taylor JL, Jones MA, Jessup M, Schaper S, Chutnow WA, Shah SH, Butler J, Sachdev V, Shah SJ. PMID: 41338833; PMCID: PMC12694977.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Psychosocial stress amplifies inflammation through NLRP3 Inflammasome activated by endoplasmic reticulum stress in the mouse heart. J Mol Cell Cardiol. 2025 Sep; 206:39-43. Diloretto D, Sarode G, Thai PN, Lee JH, Navar E, Park JE, Khadilkar C, Zong N, Dong YJ, Duda A, Romero E, Acevedo PE, Zhang XD, Liem DA, Ebong I, Lopez JE, Bang H, Chen CY, Izu L, Cadeiras M, Yamoah EN, Chiamvimonvat N, Sirish P. PMID: 40653306; PMCID: PMC12834132.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Awe reduces depressive symptoms and improves well-being in a randomized-controlled clinical trial. Sci Rep. 2025 May 12; 15(1):16453. Monroy M, Amster M, Eagle J, Zerwas FK, Keltner D, López JE. PMID: 40355653; PMCID: PMC12069556.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Older Adults With Cardiovascular Disease and Their Care Partners: An Analysis of Care Needs, Care Activities, and Care Partner Stress and Mental Health. J Cardiovasc Nurs. 2026 Jan-Feb 01; 41(1):E1-E10. Bidwell JT, Fauer AJ, Howe RJ, Saylor MA, Lee CS, López JE, Godden M, Hinton L. PMID: 40148260; PMCID: PMC12353095.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Association of Neighborhood and Environmental Factors With Clinical Phenotypes and Outcomes in Heart Failure With Preserved Ejection Fraction. Circ Res. 2024 Jun 21; 135(1):155-158. Liem DA, Silva H, Romero E, Rocha P, Acevedo PE, Izu MR, Ballal A, Soroya M, López JE, Nuno MA, Quazi A, Mukherjee C, Linklater W, Ebong I, Zhang XD, Izu LT, Sirish P, Chiamvimonvat N, Cadeiras M. PMID: 38759107; PMCID: PMC11189721.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. Clinical, Echocardiographic, and Longitudinal Characteristics Associated With Heart Failure With Improved Ejection Fraction. Am J Cardiol. 2024 01 15; 211:143-152. Romero E, Baltodano AF, Rocha P, Sellers-Porter C, Patel DJ, Soroya S, Bidwell J, Ebong I, Gibson M, Liem DA, Jimenez S, Bang H, Sirish P, Chiamvimonvat N, Lopez JE, Cadeiras M. PMID: 37923155; PMCID: PMC10869234.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    10. Total-Body Perfusion Imaging with [11C]-Butanol. J Nucl Med. 2023 11; 64(11):1831-1838. Li EJ, López JE, Spencer BA, Abdelhafez Y, Badawi RD, Wang G, Cherry SR. PMID: 37652544; PMCID: PMC10626376.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    11. MapperPlus: Agnostic clustering of high-dimension data for precision medicine. PLOS Digit Health. 2023 Aug; 2(8):e0000307. Datta E, Ballal A, López JE, Izu LT. PMID: 37556425; PMCID: PMC10411786.
      View in: PubMed   Mentions: 3  
    12. Telomeres Fuse During Cardiomyocyte Maturation. Circulation. 2023 05 23; 147(21):1634-1636. Aix E, Gallinat A, Yago-Díez C, Lucas J, Gómez MJ, Benguría A, Freitag P, Cortez-Toledo E, Fernández de Manuel L, García-Cuasimodo L, Sánchez-Iranzo H, Montoya MC, Dopazo A, Sánchez-Cabo F, Mercader N, López JE, Fleischmann BK, Hesse M, Flores I. PMID: 37216436.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    13. Educational video while "waiting-to-be-seen" in a cardiology outpatient clinic promotes opt-in self-consent for biobanking of remnant clinical biospecimens: A randomized-controlled trial. J Clin Transl Sci. 2023; 7(1):e103. López JE, Kyle A, Hosseini AJ, Wilson M, Soares S. PMID: 37250987; PMCID: PMC10225258.
      View in: PubMed   Mentions: 1  
    14. Medical Disruptions During Center-Based Cardiac Rehabilitation: A Necessary Appraisal for the Development of Emerging Remote and Virtual Care Models. J Cardiopulm Rehabil Prev. 2023 09 01; 43(5):329-337. Khong A, Liu N, Giancaterino S, Junker M, Labiak R, Cortez-Toledo E, Fausto AGB, Andrade H, Chen C, López JE. PMID: 36811521.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Increased length-dependent activation of human engineered heart tissue after chronic α1A-adrenergic agonist treatment: testing a novel heart failure therapy. Am J Physiol Heart Circ Physiol. 2023 03 01; 324(3):H293-H304. Rupert C, López JE, Cortez-Toledo E, De la Cruz Cabrera O, Chesler NC, Simpson PC, Campbell SG, Baker AJ. PMID: 36637971; PMCID: PMC9886349.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    16. Blanching Defects at the Pressure Points: Observations from Dynamic Total-Body PET/CT Studies. J Nucl Med Technol. 2022 Apr 19. Abdelhafez YG, Mcbride KM, Leung EK, Hunt HH, Spencer BA, Lopez JE, Atsina K, Li EJ, Wang G, Cherry SR, Badawi RD, Sen F, Nardo L. PMID: 35440473; PMCID: PMC9745988.
      View in: PubMed   Mentions: 1     Fields:    
    17. Multiparametric cardiac18F-FDG PET in humans: pilot comparison of FDG delivery rate with82Rb myocardial blood flow. Phys Med Biol. 2021 07 30; 66(15). Zuo Y, López JE, Smith TW, Foster CC, Carson RE, Badawi RD, Wang G. PMID: 34280905.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    18. Multiparametric Cardiac 18F-FDG PET in Humans: Kinetic Model Selection and Identifiability Analysis. IEEE Trans Radiat Plasma Med Sci. 2020 Nov; 4(6):759-767. Zuo Y, Badawi RD, Foster CC, Smith T, López JE, Wang G. PMID: 33778234; PMCID: PMC7996630.
      View in: PubMed   Mentions: 10  
    19. Engaging heart failure patients from a clinical data research network: A survey on willingness to participate in different types of research. AMIA Annu Symp Proc. 2019; 2019:305-312. Choi YK, López JE, Meeker D, Ohno-Machado L, Kim KK, pSCANNER Team. PMID: 32308823; PMCID: PMC7153117.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. Modeling Clinical Processes to Consent Research Donors of Remnant Biospecimens in an Outpatient Cardiology Clinic. Biopreserv Biobank. 2020 Apr; 18(2):53-63. Soares SE, Anderson NR, Solis LJ, López JE. PMID: 31880471; PMCID: PMC7185316.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    21. Genome-wide analysis revealed sex-specific gene expression in asthmatics. Hum Mol Genet. 2019 08 01; 28(15):2600-2614. Gautam Y, Afanador Y, Abebe T, López JE, Mersha TB. PMID: 31095684; PMCID: PMC6644163.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    22. Conspicuity of suspicious breast lesions on contrast enhanced breast CT compared to digital breast tomosynthesis and mammography. Br J Radiol. 2019 May; 92(1097):20181034. Aminololama-Shakeri S, Abbey CK, López JE, Hernandez AM, Gazi P, Boone JM, Lindfors KK. PMID: 30810339; PMCID: PMC6580915.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    23. The Doctor-Patient Relationship With Artificial Intelligence. AJR Am J Roentgenol. 2019 02; 212(2):308-310. Aminololama-Shakeri S, López JE. PMID: 30540210.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    24. Implementation of High-Sensitivity Cardiac Troponin: Challenges From the International Experience. Crit Pathw Cardiol. 2018 12; 17(4):173-178. Howell SJ, Amsterdam EA, Mumma BE, López JE, Tran NK. PMID: 30418246; PMCID: PMC6234850.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    25. Highly efficient transfection of human induced pluripotent stem cells using magnetic nanoparticles. Int J Nanomedicine. 2018; 13:6073-6078. Yamoah MA, Moshref M, Sharma J, Chen WC, Ledford HA, Lee JH, Chavez KS, Wang W, López JE, Lieu DK, Sirish P, Zhang XD. PMID: 30323594; PMCID: PMC6179720.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    26. Impact of the California Breast Density Law on Screening Breast MR Utilization, Provider Ordering Practices, and Patient Demographics. J Am Coll Radiol. 2018 Apr; 15(4):594-600. Ram S, Sarma N, López JE, Liu Y, Li CS, Aminololama-Shakeri S. PMID: 29622173.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansPHPublic Health
    27. Aspirin and clopidogrel high on-treatment platelet reactivity and genetic predictors in peripheral arterial disease. Catheter Cardiovasc Interv. 2018 06; 91(7):1308-1317. Yeo KK, Armstrong EJ, López JE, Chen DC, Westin GG, Li CS, Anderson D, Hua A, Singapuri A, Amsterdam EA, Chiamvimonvat N, Laird JR. PMID: 29411531; PMCID: PMC5997520.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    28. A method to increase reproducibility in adult ventricular myocyte sizing and flow cytometry: Avoiding cell size bias in single cell preparations. PLoS One. 2017; 12(10):e0186792. López JE, Jaradeh K, Silva E, Aminololama-Shakeri S, Simpson PC. PMID: 29084228; PMCID: PMC5662089.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    29. Novel large-particle FACS purification of adult ventricular myocytes reveals accumulation of myosin and actin disproportionate to cell size and proteome in normal post-weaning development. J Mol Cell Cardiol. 2017 10; 111:114-122. López JE, Sharma J, Avila J, Wood TS, VanDyke JE, McLaughlin B, Abbey CK, Wong A, Myagmar BE, Swigart PM, Simpson PC, Chiamvimonvat N. PMID: 28780067; PMCID: PMC5791888.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    30. Molecular Mechanisms and New Treatment Paradigm for Atrial Fibrillation. Circ Arrhythm Electrophysiol. 2016 May; 9(5). Sirish P, Li N, Timofeyev V, Zhang XD, Wang L, Yang J, Lee KS, Bettaieb A, Ma SM, Lee JH, Su D, Lau VC, Myers RE, Lieu DK, López JE, Young JN, Yamoah EN, Haj F, Ripplinger CM, Hammock BD, Chiamvimonvat N. PMID: 27162031; PMCID: PMC4869994.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    31. Cardiac extracellular matrix proteomics: Challenges, techniques, and clinical implications. Proteomics Clin Appl. 2016 Jan; 10(1):39-50. Chang CW, Dalgliesh AJ, López JE, Griffiths LG. PMID: 26200932; PMCID: PMC4703519.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    32. Feedback mechanisms for cardiac-specific microRNAs and cAMP signaling in electrical remodeling. Circ Arrhythm Electrophysiol. 2015 Aug; 8(4):942-50. Myers R, Timofeyev V, Li N, Kim C, Ledford HA, Sirish P, Lau V, Zhang Y, Fayyaz K, Singapuri A, Lopez JE, Knowlton AA, Zhang XD, Chiamvimonvat N. PMID: 25995211; PMCID: PMC4545299.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    33. Unique mechanistic insights into the beneficial effects of soluble epoxide hydrolase inhibitors in the prevention of cardiac fibrosis. Proc Natl Acad Sci U S A. 2013 Apr 02; 110(14):5618-23. Sirish P, Li N, Liu JY, Lee KS, Hwang SH, Qiu H, Zhao C, Ma SM, López JE, Hammock BD, Chiamvimonvat N. PMID: 23493561; PMCID: PMC3619365.
      View in: PubMed   Mentions: 58     Fields:    Translation:Animals
    34. MicroRNA profiling predicts a variance in the proliferative potential of cardiac progenitor cells derived from neonatal and adult murine hearts. J Mol Cell Cardiol. 2012 Jan; 52(1):264-72. Sirish P, López JE, Li N, Wong A, Timofeyev V, Young JN, Majdi M, Li RA, Chen HS, Chiamvimonvat N. PMID: 22062954; PMCID: PMC3362795.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    35. β-myosin heavy chain is induced by pressure overload in a minor subpopulation of smaller mouse cardiac myocytes. Circ Res. 2011 Sep 02; 109(6):629-38. López JE, Myagmar BE, Swigart PM, Montgomery MD, Haynam S, Bigos M, Rodrigo MC, Simpson PC. PMID: 21778428; PMCID: PMC3166391.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    36. Disruption of adenylyl cyclase type V does not rescue the phenotype of cardiac-specific overexpression of Galphaq protein-induced cardiomyopathy. Am J Physiol Heart Circ Physiol. 2010 Nov; 299(5):H1459-67. Timofeyev V, Porter CA, Tuteja D, Qiu H, Li N, Tang T, Singapuri A, Han PL, Lopez JE, Hammond HK, Chiamvimonvat N. PMID: 20709863; PMCID: PMC2993201.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    37. Recovery of methamphetamine associated cardiomyopathy predicted by late gadolinium enhanced cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2009 Nov 11; 11:46. Lopez JE, Yeo K, Caputo G, Buonocore M, Schaefer S. PMID: 19906310; PMCID: PMC2780987.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    38. Stem cell antigen-1 regulates the tempo of muscle repair through effects on proliferation of alpha7 integrin-expressing myoblasts. Exp Cell Res. 2008 Mar 10; 314(5):1125-35. Epting CL, López JE, Pedersen A, Brown C, Spitz P, Ursell PC, Bernstein HS. PMID: 18073129; PMCID: PMC2292416.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    39. Stem cell antigen-1 is necessary for cell-cycle withdrawal and myoblast differentiation in C2C12 cells. J Cell Sci. 2004 Dec 01; 117(Pt 25):6185-95. Epting CL, López JE, Shen X, Liu L, Bristow J, Bernstein HS. PMID: 15546912.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    40. Cardiac fibroblasts arrest at the G1/S restriction point in response to interleukin (IL)-1beta. Evidence for IL-1beta-induced hypophosphorylation of the retinoblastoma protein. J Biol Chem. 1998 Oct 02; 273(40):25796-803. Koudssi F, López JE, Villegas S, Long CS. PMID: 9748252.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
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