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Bruce Hammock

TitleDistinguished Professor
InstitutionUniversity of California Davis
DepartmentEntomology
Address90 Briggs Hall
CA 95616
Phone530-752-7519
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lakkappa N, Krishnamurthy PT, M D P, Hammock BD, Hwang SH. Soluble epoxide hydrolase inhibitor, APAU, protects dopaminergic neurons against rotenone induced neurotoxicity: Implications for Parkinson's disease. Neurotoxicology. 2018 Nov 22; 70:135-145. PMID: 30472438.
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    2. Hennebelle M, Metherel AH, Kitson AP, Otoki Y, Yang J, Lee KSS, Hammock BD, Bazinet RP, Taha AY. Brain oxylipin concentrations following hypercapnia / ischemia: effects of brain dissection and dissection time. J Lipid Res. 2018 Nov 21. PMID: 30463986.
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    3. Zarriello S, Tuazon J, Corey S, Schimmel S, Rajani M, Gorsky A, Incontri D, Hammock BD, Borlongan CV. Humble beginnings with big goals: Small molecule soluble epoxide hydrolase inhibitors for treating CNS disorders. Prog Neurobiol. 2018 Nov 14. PMID: 30447256.
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    4. Kodani SD, Wan D, Wagner KM, Hwang SH, Morisseau C, Hammock BD. Design and Potency of Dual Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase Inhibitors. ACS Omega. 2018 Oct 31; 3(10):14076-14086. PMID: 30411058.
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    5. Huo J, Li Z, Wan D, Li D, Qi M, Barnych B, Vasylieva N, Zhang J, Hammock BD. Development of a Highly Sensitive Direct Competitive Fluorescence Enzyme Immunoassay Based on a Nanobody-Alkaline Phosphatase Fusion Protein for Detection of 3-Phenoxybenzoic Acid in Urine. J Agric Food Chem. 2018 Oct 17. PMID: 30293433.
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    6. Harris TR, Kodani S, Rand AA, Yang J, Imai DM, Hwang SH, Hammock BD. Celecoxib does not protect against fibrosis and inflammation in a carbon tetrachloride-induced model of liver injury. Mol Pharmacol. 2018 May 29. PMID: 29844231.
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    7. Burmistrov V, Morisseau C, Pitushkin D, Karlov D, Fayzullin RR, Butov GM, Hammock BD. Adamantyl thioureas as soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett. 2018 May 23. PMID: 29803731.
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    8. Minaz N, Razdan R, Hammock BD, Goswami SK. An inhibitor of soluble epoxide hydrolase ameliorates diabetes-induced learning and memory impairment in rats. Prostaglandins Other Lipid Mediat. 2018 May 08. PMID: 29751149.
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    9. Ren Q, Ma M, Yang J, Nonaka R, Yamaguchi A, Ishikawa KI, Kobayashi K, Murayama S, Hwang SH, Saiki S, Akamatsu W, Hattori N, Hammock BD, Hashimoto K. Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease. Proc Natl Acad Sci U S A. 2018 May 07. PMID: 29735655.
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    10. Wang W, Yang J, Zhang J, Wang Y, Hwang SH, Qi W, Wan D, Kim D, Sun J, Sanidad KZ, Yang H, Park Y, Liu JY, Zhao X, Zheng X, Liu Z, Hammock BD, Zhang G. Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation. Proc Natl Acad Sci U S A. 2018 May 15; 115(20):5283-5288. PMID: 29717038.
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    11. Cui X, Vasylieva N, Shen D, Barnych B, Yang J, He Q, Jiang Z, Zhao S, Hammock BD. Biotinylated single-chain variable fragment-based enzyme-linked immunosorbent assay for glycocholic acid. Analyst. 2018 Apr 30; 143(9):2057-2065. PMID: 29629470.
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    12. Lee KSS, Liu JY, Wagner KM, Pakhomova S, Dong H, Morisseau C, Fu SH, Yang J, Wang P, Ulu A, Mate CA, Nguyen LV, Hwang SH, Edin ML, Mara AA, Wulff H, Newcomer ME, Zeldin DC, Hammock BD. Correction to Optimized Inhibitors of Soluble Epoxide Hydrolase Improve in Vitro Target Residence Time and in Vivo Efficacy. J Med Chem. 2018 May 10; 61(9):4271. PMID: 29701466.
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    13. Blöcher R, Wagner KM, Gopireddy RR, Harris TR, Wu H, Barnych B, Hwang SH, Xiang YK, Proschak E, Morisseau C, Hammock BD. Orally Available Soluble Epoxide Hydrolase/Phosphodiesterase 4 Dual Inhibitor Treats Inflammatory Pain. J Med Chem. 2018 Apr 26; 61(8):3541-3550. PMID: 29614224.
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    14. Bever CS, Rand AA, Nording M, Taft D, Kalanetra KM, Mills DA, Breck MA, Smilowitz JT, German JB, Hammock BD. Effects of triclosan in breast milk on the infant fecal microbiome. Chemosphere. 2018 Jul; 203:467-473. PMID: 29635158.
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    15. Tu R, Armstrong J, Lee KSS, Hammock BD, Sapirstein A, Koehler RC. Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia. Sci Rep. 2018 Mar 27; 8(1):5279. PMID: 29588470.
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    16. Hao L, Kearns J, Scott S, Wu D, Kodani SD, Morisseau C, Hammock BD, Sun X, Zhao L, Wang S. Indomethacin Enhances Brown Fat Activity. J Pharmacol Exp Ther. 2018 Jun; 365(3):467-475. PMID: 29567865.
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    17. Certíková Chábová V, Kujal P, Škaroupková P, Varnourková Z, Vacková Š, Husková Z, Kikerlová S, Sadowski J, Kompanowska-Jezierska E, Baranowska I, Hwang SH, Hammock BD, Imig JD, Tesar V, Cervenka L. Combined Inhibition of Soluble Epoxide Hydrolase and Renin-Angiotensin System Exhibits Superior Renoprotection to Renin-Angiotensin System Blockade in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats with Established Chronic Kidney Disease. Kidney Blood Press Res. 2018 Mar 06; 43(2):329-349. PMID: 29529602.
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    18. Bastan I, Ge XN, Dileepan M, Greenberg YG, Guedes AG, Hwang SH, Hammock BD, Washabau RJ, Rao SP, Sriramarao P. Inhibition of soluble epoxide hydrolase attenuates eosinophil recruitment and food allergen-induced gastrointestinal inflammation. J Leukoc Biol. 2018 Jan 17. PMID: 29345370.
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    19. Kodani SD, Bhakta S, Hwang SH, Pakhomova S, Newcomer ME, Morisseau C, Hammock BD. Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase. Bioorg Med Chem Lett. 2018 Feb 15; 28(4):762-768. PMID: 29366648.
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    20. Yang YM, Sun D, Kandhi S, Froogh G, Zhuge J, Huang W, Hammock BD, Huang A. Estrogen-dependent epigenetic regulation of soluble epoxide hydrolase via DNA methylation. Proc Natl Acad Sci U S A. 2018 Jan 16; 115(3):613-618. PMID: 29295935.
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    21. Cam M, Durieu E, Bodin M, Manousopoulou A, Koslowski S, Vasylieva N, Barnych B, Hammock BD, Bohl B, Koch P, Omori C, Yamamoto K, Hata S, Suzuki T, Karg F, Gizzi P, Haber VE, Bencetic Mihaljevic V, Tavcar B, Portelius E, Pannee J, Blennow K, Zetterberg H, Garbis SD, Auvray P, Gerber H, Fraering J, Fraering PC, Meijer L. Induction of Amyloid-ß42 Production by Fipronil and Other Pyrazole Insecticides. J Alzheimers Dis. 2018; 62(4):1663-1681. PMID: 29504531.
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    22. Rand AA, Helmer PO, Inceoglu B, Hammock BD, Morisseau C. LC-MS/MS Analysis of the Epoxides and Diols Derived from the Endocannabinoid Arachidonoyl Ethanolamide. Methods Mol Biol. 2018; 1730:123-133. PMID: 29363071.
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    23. Burmistrov V, Morisseau C, Harris TR, Butov G, Hammock BD. Effects of adamantane alterations on soluble epoxide hydrolase inhibition potency, physical properties and metabolic stability. Bioorg Chem. 2018 Feb; 76:510-527. PMID: 29310082.
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    24. Hu J, Dziumbla S, Lin J, Bibli SI, Zukunft S, de Mos J, Awwad K, Frömel T, Jungmann A, Devraj K, Cheng Z, Wang L, Fauser S, Eberhart CG, Sodhi A, Hammock BD, Liebner S, Müller OJ, Glaubitz C, Hammes HP, Popp R, Fleming I. Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy. Nature. 2017 12 14; 552(7684):248-252. PMID: 29211719.
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    25. Deng BQ, Luo Y, Kang X, Li CB, Morisseau C, Yang J, Lee KSS, Huang J, Hu DY, Wu MY, Peng A, Hammock BD, Liu JY. Epoxide metabolites of arachidonate and docosahexaenoate function conversely in acute kidney injury involved in GSK3ß signaling. Proc Natl Acad Sci U S A. 2017 Nov 21; 114(47):12608-12613. PMID: 29109264.
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    26. Kodani SD, Barthélemy M, Kamita SG, Hammock B, Morisseau C. Development of amide-based fluorescent probes for selective measurement of carboxylesterase 1 activity in tissue extracts. Anal Biochem. 2017 12 15; 539:81-89. PMID: 29054529.
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    27. Cui X, Vasylieva N, Wu P, Barnych B, Yang J, Shen D, He Q, Gee SJ, Zhao S, Hammock BD. Development of an Indirect Competitive Enzyme-Linked Immunosorbent Assay for Glycocholic Acid Based on Chicken Single-Chain Variable Fragment Antibodies. Anal Chem. 2017 Oct 17; 89(20):11091-11097. PMID: 28942640.
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    28. Inceoglu B, Bettaieb A, Haj FG, Gomes AV, Hammock BD. Modulation of mitochondrial dysfunction and endoplasmic reticulum stress are key mechanisms for the wide-ranging actions of epoxy fatty acids and soluble epoxide hydrolase inhibitors. Prostaglandins Other Lipid Mediat. 2017 Nov; 133:68-78. PMID: 28847566.
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    29. Hasegawa E, Inafuku S, Mulki L, Okunuki Y, Yanai R, Smith KE, Kim CB, Klokman G, Bielenberg DR, Puli N, Falck JR, Husain D, Miller JW, Edin ML, Zeldin DC, Lee KSS, Hammock BD, Schunck WH, Connor KM. Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization. Proc Natl Acad Sci U S A. 2017 Sep 05; 114(36):E7545-E7553. PMID: 28827330.
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    30. Bettaieb A, Koike S, Hsu MF, Ito Y, Chahed S, Bachaalany S, Gruzdev A, Calvo-Rubio M, Lee KSS, Inceoglu B, Imig JD, Villalba JM, Zeldin DC, Hammock BD, Haj FG. Soluble epoxide hydrolase in podocytes is a significant contributor to renal function under hyperglycemia. Biochim Biophys Acta. 2017 11; 1861(11 Pt A):2758-2765. PMID: 28757338.
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    31. Yang J, Oh YT, Wan D, Watanabe RM, Hammock BD, Youn JH. Postprandial effect to decrease soluble epoxide hydrolase activity: roles of insulin and gut microbiota. J Nutr Biochem. 2017 Nov; 49:8-14. PMID: 28863368.
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    32. Hennebelle M, Zhang Z, Metherel AH, Kitson AP, Otoki Y, Richardson CE, Yang J, Lee KSS, Hammock BD, Zhang L, Bazinet RP, Taha AY. Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission. Sci Rep. 2017 Jun 28; 7(1):4342. PMID: 28659576.
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    33. Wagner KM, McReynolds CB, Schmidt WK, Hammock BD. Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases. Pharmacol Ther. 2017 Dec; 180:62-76. PMID: 28642117.
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    34. Islam O, Patil P, Goswami SK, Razdan R, Inamdar MN, Rizwan M, Mathew J, Inceoglu B, Stephen Lee KS, Hwang SH, Hammock BD. Inhibitors of soluble epoxide hydrolase minimize ischemia-reperfusion-induced cardiac damage in normal, hypertensive, and diabetic rats. Cardiovasc Ther. 2017 Jun; 35(3). PMID: 28296232.
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    35. Barnych B, Vasylieva N, Joseph T, Hulsizer S, Nguyen HM, Cajka T, Pessah I, Wulff H, Gee SJ, Hammock BD. Development of Tetramethylenedisulfotetramine (TETS) Hapten Library: Synthesis, Electrophysiological Studies, and Immune Response in Rabbits. Chemistry. 2017 Jun 22; 23(35):8466-8472. PMID: 28411375.
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    36. Bettaieb A, Koike S, Chahed S, Zhao Y, Bachaalany S, Hashoush N, Graham J, Fatima H, Havel PJ, Gruzdev A, Zeldin DC, Hammock BD, Haj FG. Podocyte-specific soluble epoxide hydrolase deficiency in mice attenuates acute kidney injury. FEBS J. 2017 07; 284(13):1970-1986. PMID: 28485854.
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    37. Barnych B, Rand AA, Cajka T, Lee KSS, Hammock BD. Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs. Org Biomol Chem. 2017 May 23; 15(20):4308-4313. PMID: 28470279.
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    38. Goswami SK, Rand AA, Wan D, Yang J, Inceoglu B, Thomas M, Morisseau C, Yang GY, Hammock BD. Pharmacological inhibition of soluble epoxide hydrolase or genetic deletion reduces diclofenac-induced gastric ulcers. Life Sci. 2017 Jul 01; 180:114-122. PMID: 28522175.
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    39. Li D, Cui Y, Morisseau C, Gee SJ, Bever CS, Liu X, Wu J, Hammock BD, Ying Y. Nanobody Based Immunoassay for Human Soluble Epoxide Hydrolase Detection Using Polymeric Horseradish Peroxidase (PolyHRP) for Signal Enhancement: The Rediscovery of PolyHRP? Anal Chem. 2017 Jun 06; 89(11):6248-6256. PMID: 28460522.
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    40. Kitamura S, Morisseau C, Harris TR, Inceoglu B, Hammock BD. Occurrence of urea-based soluble epoxide hydrolase inhibitors from the plants in the order Brassicales. PLoS One. 2017; 12(5):e0176571. PMID: 28472063.
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    41. Zhou Y, Liu T, Duan JX, Li P, Sun GY, Liu YP, Zhang J, Dong L, Lee KSS, Hammock BD, Jiang JX, Guan CX. Soluble Epoxide Hydrolase Inhibitor Attenuates Lipopolysaccharide-Induced Acute Lung Injury and Improves Survival in Mice. Shock. 2017 05; 47(5):638-645. PMID: 27753791.
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    42. Vasylieva N, Barnych B, Rand A, Inceoglu B, Gee SJ, Hammock BD. Sensitive Immunoassay for Detection and Quantification of the Neurotoxin, Tetramethylenedisulfotetramine. Anal Chem. 2017 May 16; 89(10):5612-5619. PMID: 28398746.
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    43. Wang Z, Fang Y, Teague J, Wong H, Morisseau C, Hammock BD, Rock DA, Wang Z. In Vitro Metabolism of Oprozomib, an Oral Proteasome Inhibitor: Role of Epoxide Hydrolases and Cytochrome P450s. Drug Metab Dispos. 2017 07; 45(7):712-720. PMID: 28428366.
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    44. Fiala M, Kooij G, Wagner K, Hammock B, Pellegrini M. Modulation of innate immunity of patients with Alzheimer's disease by omega-3 fatty acids. FASEB J. 2017 08; 31(8):3229-3239. PMID: 28420693.
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    45. Rand AA, Barnych B, Morisseau C, Cajka T, Lee KSS, Panigrahy D, Hammock BD. Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids. Proc Natl Acad Sci U S A. 2017 04 25; 114(17):4370-4375. PMID: 28396419.
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    46. Hvorecny KL, Bahl CD, Kitamura S, Lee KSS, Hammock BD, Morisseau C, Madden DR. Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase. Structure. 2017 05 02; 25(5):697-707.e4. PMID: 28392259.
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    47. Trindade-da-Silva CA, Bettaieb A, Napimoga MH, Lee KSS, Inceoglu B, Ueira-Vieira C, Bruun D, Goswami SK, Haj FG, Hammock BD. Soluble Epoxide Hydrolase Pharmacological Inhibition Decreases Alveolar Bone Loss by Modulating Host Inflammatory Response, RANK-Related Signaling, Endoplasmic Reticulum Stress, and Apoptosis. J Pharmacol Exp Ther. 2017 Jun; 361(3):408-416. PMID: 28356494.
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    48. Vasylieva N, Barnych B, Wan D, El-Sheikh EA, Nguyen HM, Wulff H, McMahen R, Strynar M, Gee SJ, Hammock BD. Hydroxy-fipronil is a new urinary biomarker of exposure to fipronil. Environ Int. 2017 06; 103:91-98. PMID: 28343720.
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    49. Wagner K, Gilda J, Yang J, Wan D, Morisseau C, Gomes AV, Hammock BD. Soluble epoxide hydrolase inhibition alleviates neuropathy in Akita (Ins2 Akita) mice. Behav Brain Res. 2017 05 30; 326:69-76. PMID: 28259677.
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    50. Hennebelle M, Otoki Y, Yang J, Hammock BD, Levitt AJ, Taha AY, Swardfager W. Altered soluble epoxide hydrolase-derived oxylipins in patients with seasonal major depression: An exploratory study. Psychiatry Res. 2017 06; 252:94-101. PMID: 28259037.
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    51. Hu P, Wu X, Khandelwal AR, Yu W, Xu Z, Chen L, Yang J, Weisbrod RM, Lee KSS, Seta F, Hammock BD, Cohen RA, Zeng C, Tong X. Endothelial Nox4-based NADPH oxidase regulates atherosclerosis via soluble epoxide hydrolase. Biochim Biophys Acta. 2017 Jun; 1863(6):1382-1391. PMID: 28185955.
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    52. Wan D, Yang J, Barnych B, Hwang SH, Lee KS, Cui Y, Niu J, Watsky MA, Hammock BD. A new sensitive LC/MS/MS analysis of vitamin D metabolites using a click derivatization reagent, 2-nitrosopyridine. J Lipid Res. 2017 Apr; 58(4):798-808. PMID: 28148721.
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    53. Zhang Y, Hong G, Lee KS, Hammock BD, Gebremedhin D, Harder DR, Koehler RC, Sapirstein A. Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen-glucose deprivation. J Neurochem. 2017 Mar; 140(5):814-825. PMID: 28002622.
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    54. Supp DM, Hahn JM, McFarland KL, Combs KA, Lee KS, Inceoglu B, Wan D, Boyce ST, Hammock BD. Soluble Epoxide Hydrolase Inhibition and Epoxyeicosatrienoic Acid Treatment Improve Vascularization of Engineered Skin Substitutes. Plast Reconstr Surg Glob Open. 2016 Dec; 4(12):e1151. PMID: 28293507.
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    55. Hwang SH, Wagner K, Xu J, Yang J, Li X, Cao Z, Morisseau C, Lee KS, Hammock BD. Chemical synthesis and biological evaluation of ?-hydroxy polyunsaturated fatty acids. Bioorg Med Chem Lett. 2017 02 01; 27(3):620-625. PMID: 28025003.
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    56. Lee KS, Henriksen NM, Ng CJ, Yang J, Jia W, Morisseau C, Andaya A, Gilson MK, Hammock BD. Probing the orientation of inhibitor and epoxy-eicosatrienoic acid binding in the active site of soluble epoxide hydrolase. Arch Biochem Biophys. 2017 Jan 01; 613:1-11. PMID: 27983948.
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    57. Datta S, Sahdeo S, Gray JA, Morriseau C, Hammock BD, Cortopassi G. A high-throughput screen for mitochondrial function reveals known and novel mitochondrial toxicants in a library of environmental agents. Mitochondrion. 2016 Nov; 31:79-83. PMID: 27717841.
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    58. Wagner SD, Kurobe T, Hammock BG, Lam CH, Wu G, Vasylieva N, Gee SJ, Hammock BD, Teh SJ. Developmental effects of fipronil on Japanese Medaka (Oryzias latipes) embryos. Chemosphere. 2017 Jan; 166:511-520. PMID: 27710886.
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    59. Liu JY, Morisseau C, Huang H, Hammock BD. Screening of soluble epoxide hydrolase inhibitory ingredients from traditional Chinese medicines for anti-inflammatory use. J Ethnopharmacol. 2016 Dec 24; 194:475-482. PMID: 27702689.
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    60. Kodani SD, Overby HB, Morisseau C, Chen J, Zhao L, Hammock BD. Parabens inhibit fatty acid amide hydrolase: A potential role in paraben-enhanced 3T3-L1 adipocyte differentiation. Toxicol Lett. 2016 Nov 16; 262:92-99. PMID: 27659731.
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    61. Harris TR, Kodani S, Yang J, Imai DM, Hammock BD. An ?-3-enriched diet alone does not attenuate CCl4-induced hepatic fibrosis. J Nutr Biochem. 2016 12; 38:93-101. PMID: 27732914.
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    62. Ghosh R, Goswami SK, Feitoza LF, Hammock B, Gomes AV. Diclofenac induces proteasome and mitochondrial dysfunction in murine cardiomyocytes and hearts. Int J Cardiol. 2016 Nov 15; 223:923-935. PMID: 27589040.
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    63. Li D, Liu Y, Zhang X, Lv H, Pang W, Sun X, Gan LM, Hammock BD, Ai D, Zhu Y. Inhibition of soluble epoxide hydrolase alleviated atherosclerosis by reducing monocyte infiltration in Ldlr(-/-) mice. J Mol Cell Cardiol. 2016 09; 98:128-37. PMID: 27496380.
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    64. Gong Y, Fu Z, Edin ML, Liu CH, Wang Z, Shao Z, Fredrick TW, Saba NJ, Morss PC, Burnim SB, Meng SS, Lih FB, Lee KS, Moran EP, SanGiovanni JP, Hellström A, Hammock BD, Zeldin DC, Smith LE. Cytochrome P450 Oxidase 2C Inhibition Adds to ?-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization. Arterioscler Thromb Vasc Biol. 2016 Sep; 36(9):1919-27. PMID: 27417579; PMCID: PMC5010176 [Available on 09/01/17].
    65. Xu J, Morisseau C, Yang J, Lee KSS, Kamita SG, Hammock BD. Ingestion of the epoxide hydrolase inhibitor AUDA modulates immune responses of the mosquito, Culex quinquefasciatus during blood feeding. Insect Biochem Mol Biol. 2016 09; 76:62-69. PMID: 27369469; PMCID: PMC5010450 [Available on 09/01/17].
    66. Akhnokh MK, Yang FH, Samokhvalov V, Jamieson KL, Cho WJ, Wagg C, Takawale A, Wang X, Lopaschuk GD, Hammock BD, Kassiri Z, Seubert JM. Inhibition of Soluble Epoxide Hydrolase Limits Mitochondrial Damage and Preserves Function Following Ischemic Injury. Front Pharmacol. 2016; 7:133. PMID: 27375480; PMCID: PMC4896112.
    67. Zhou Y, Yang J, Sun GY, Liu T, Duan JX, Zhou HF, Lee KS, Hammock BD, Fang X, Jiang JX, Guan CX. Erratum to: Soluble epoxide hydrolase inhibitor 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea attenuates bleomycin-induced pulmonary fibrosis in mice. Cell Tissue Res. 2016 06; 364(3):675. PMID: 26946414.
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    68. Ulu A, Inceoglu B, Yang J, Singh V, Vito S, Wulff H, Hammock BD. Inhibition of soluble epoxide hydrolase as a novel approach to high dose diazepam induced hypotension. J Clin Toxicol. 2016 Jun; 6(3). PMID: 28255523.
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    69. Bever CS, Dong JX, Vasylieva N, Barnych B, Cui Y, Xu ZL, Hammock BD, Gee SJ. VHH antibodies: emerging reagents for the analysis of environmental chemicals. Anal Bioanal Chem. 2016 Sep; 408(22):5985-6002. PMID: 27209591; PMCID: PMC4983233 [Available on 09/01/17].
    70. Sharma A, Hye Khan MA, Levick SP, Lee KS, Hammock BD, Imig JD. Novel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosis. Int J Mol Sci. 2016 May 18; 17(5). PMID: 27213332; PMCID: PMC4881572.
    71. Taha AY, Hennebelle M, Yang J, Zamora D, Rapoport SI, Hammock BD, Ramsden CE. Regulation of rat plasma and cerebral cortex oxylipin concentrations with increasing levels of dietary linoleic acid. Prostaglandins Leukot Essent Fatty Acids. 2016 May 11. PMID: 27282298.
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    72. Sirish P, Li N, Timofeyev V, Zhang XD, Wang L, Yang J, Lee KS, Bettaieb A, Ma SM, Lee JH, Su D, Lau VC, Myers RE, Lieu DK, López JE, Young JN, Yamoah EN, Haj F, Ripplinger CM, Hammock BD, Chiamvimonvat N. Molecular Mechanisms and New Treatment Paradigm for Atrial Fibrillation. Circ Arrhythm Electrophysiol. 2016 May; 9(5). PMID: 27162031; PMCID: PMC4869994 [Available on 05/01/17].
    73. Kamita SG, Mulligan S, Cornel AJ, Hammock BD. Quantification of GST and esterase activities in pyrethrin-resistant mosquitoes using pyrethroid-like fluorescent substrates. Int J Pest Manag. 2016; 62(4):276-283. PMID: 28736488.
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    74. Ahn KC, Ranganathan A, Bever CS, Hwang SH, Holland EB, Morisseau K, Pessah IN, Hammock BD, Gee SJ. Detection of the Antimicrobial Triclosan in Environmental Samples by Immunoassay. Environ Sci Technol. 2016 Apr 05; 50(7):3754-61. PMID: 26937944; PMCID: PMC4821808 [Available on 04/05/17].
    75. Goswami SK, Wan D, Yang J, Trindade da Silva CA, Morisseau C, Kodani SD, Yang GY, Inceoglu B, Hammock BD. Anti-Ulcer Efficacy of Soluble Epoxide Hydrolase Inhibitor TPPU on Diclofenac-Induced Intestinal Ulcers. J Pharmacol Exp Ther. 2016 06; 357(3):529-36. PMID: 26989141; PMCID: PMC4885505.
    76. Ren Q, Ma M, Ishima T, Morisseau C, Yang J, Wagner KM, Zhang JC, Yang C, Yao W, Dong C, Han M, Hammock BD, Hashimoto K. Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress. Proc Natl Acad Sci U S A. 2016 Mar 29; 113(13):E1944-52. PMID: 26976569; PMCID: PMC4822604.
    77. Zhao Y, Wan D, Yang J, Hammock BD, Ortiz de Montellano PR. Catalytic Activities of Tumor-Specific Human Cytochrome P450 CYP2W1 Toward Endogenous Substrates. Drug Metab Dispos. 2016 May; 44(5):771-80. PMID: 26936974; PMCID: PMC4851306 [Available on 05/01/17].
    78. Tong X, Khandelwal AR, Wu X, Xu Z, Yu W, Chen C, Zhao W, Yang J, Qin Z, Weisbrod RM, Seta F, Ago T, Lee KS, Hammock BD, Sadoshima J, Cohen RA, Zeng C. Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase. J Mol Cell Cardiol. 2016 Mar; 92:30-40. PMID: 26812119; PMCID: PMC5008453 [Available on 03/01/17].
    79. Chen CC, Xing L, Stark M, Ou T, Holla P, Xiao K, Kamita SG, Hammock BD, Lam K, Cheng RH. Chemically activatable viral capsid functionalized for cancer targeting. Nanomedicine (Lond). 2016 Feb; 11(4):377-90. PMID: 26786134; PMCID: PMC4910953 [Available on 02/01/17].
    80. McLellan GJ, Aktas Z, Hennes-Beean E, Kolb AW, Larsen IV, Schmitz EJ, Clausius HR, Yang J, Hwang SH, Morisseau C, Inceoglu B, Hammock BD, Brandt CR. Effect of a Soluble Epoxide Hydrolase Inhibitor, UC1728, on LPS-Induced Uveitis in the Rabbit. J Ocul Biol. 2016 Jan; 4(1). PMID: 28066796.
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    81. Liao J, Hwang SH, Li H, Liu JY, Hammock BD, Yang GY. Inhibition of Chronic Pancreatitis and Murine Pancreatic Intraepithelial Neoplasia by a Dual Inhibitor of c-RAF and Soluble Epoxide Hydrolase in LSL-KrasG¹²D/Pdx-1-Cre Mice. Anticancer Res. 2016 Jan; 36(1):27-37. PMID: 26722025; PMCID: PMC4793710.
    82. Liao J, Hwang SH, Li H, Yang Y, Yang J, Wecksler AT, Liu JY, Hammock BD, Yang GY. Inhibition of mutant KrasG12D-initiated murine pancreatic carcinoma growth by a dual c-Raf and soluble epoxide hydrolase inhibitor t-CUPM. Cancer Lett. 2016 Feb 28; 371(2):187-93. PMID: 26683769; PMCID: PMC4738175 [Available on 02/28/17].
    83. Rossotti MA, Pirez M, Gonzalez-Techera A, Cui Y, Bever CS, Lee KS, Morisseau C, Leizagoyen C, Gee S, Hammock BD, González-Sapienza G. Method for Sorting and Pairwise Selection of Nanobodies for the Development of Highly Sensitive Sandwich Immunoassays. Anal Chem. 2015 Dec 01; 87(23):11907-14. PMID: 26544909; PMCID: PMC4666776 [Available on 12/01/16].
    84. Goswami SK, Inceoglu B, Yang J, Wan D, Kodani SD, da Silva CA, Morisseau C, Hammock BD. Omeprazole increases the efficacy of a soluble epoxide hydrolase inhibitor in a PGE2 induced pain model. Toxicol Appl Pharmacol. 2015 Dec 15; 289(3):419-27. PMID: 26522832; PMCID: PMC4666679 [Available on 12/15/16].
    85. Burmistrov V, Morisseau C, Danilov D, Harris TR, Dalinger I, Vatsadze I, Shkineva T, Butov GM, Hammock BD. 1,3-Disubstituted and 1,3,3-trisubstituted adamantyl-ureas with isoxazole as soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett. 2015 Dec 01; 25(23):5514-9. PMID: 26520661; PMCID: PMC4654407 [Available on 12/01/16].
    86. Kim IH, Park YK, Nishiwaki H, Hammock BD, Nishi K. Structure-activity relationships of amide-phosphonate derivatives as inhibitors of the human soluble epoxide hydrolase. Bioorg Med Chem. 2015 Nov 15; 23(22):7199-210. PMID: 26507430.
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    87. El-Sheikh el-SA, Kamita SG, Hammock BD. Effects of juvenile hormone (JH) analog insecticides on larval development and JH esterase activity in two spodopterans. Pestic Biochem Physiol. 2016 Mar; 128:30-6. PMID: 26969437.
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    88. Liu JY, Tsai HJ, Morisseau C, Lango J, Hwang SH, Watanabe T, Kim IH, Hammock BD. In vitro and in vivo metabolism of N-adamantyl substituted urea-based soluble epoxide hydrolase inhibitors. Biochem Pharmacol. 2015 Dec 15; 98(4):718-31. PMID: 26494425; PMCID: PMC4656071 [Available on 12/15/16].
    89. Wang Q, Huo L, He J, Ding W, Su H, Tian D, Welch C, Hammock BD, Ai D, Zhu Y. Soluble epoxide hydrolase is involved in the development of atherosclerosis and arterial neointima formation by regulating smooth muscle cell migration. Am J Physiol Heart Circ Physiol. 2015 Dec 01; 309(11):H1894-903. PMID: 26453326.
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    90. Zhou Y, Yang J, Sun GY, Liu T, Duan JX, Zhou HF, Lee KS, Hammock BD, Fang X, Jiang JX, Guan CX. Soluble epoxide hydrolase inhibitor 1-trifluoromethoxyphenyl-3- (1-propionylpiperidin-4-yl) urea attenuates bleomycin-induced pulmonary fibrosis in mice. Cell Tissue Res. 2016 02; 363(2):399-409. PMID: 26310139; PMCID: PMC4738109 [Available on 02/01/17].
    91. Ranganathan A, Gee SJ, Hammock BD. An immunoassay for the detection of triclosan-O-glucuronide, a primary human urinary metabolite of triclosan. Anal Bioanal Chem. 2015 Sep; 407(24):7263-73. PMID: 26255293; PMCID: PMC4580343.
    92. Vasylieva N, Ahn KC, Barnych B, Gee SJ, Hammock BD. Development of an Immunoassay for the Detection of the Phenylpyrazole Insecticide Fipronil. Environ Sci Technol. 2015 Aug 18; 49(16):10038-47. PMID: 26196357; PMCID: PMC4605820.
    93. Cui Y, Li D, Morisseau C, Dong JX, Yang J, Wan D, Rossotti MA, Gee SJ, González-Sapienza GG, Hammock BD. Heavy chain single-domain antibodies to detect native human soluble epoxide hydrolase. Anal Bioanal Chem. 2015 Sep; 407(24):7275-83. PMID: 26229025; PMCID: PMC4573264.
    94. Hwang VJ, Kim J, Rand A, Yang C, Sturdivant S, Hammock B, Bell PD, Guay-Woodford LM, Weiss RH. The cpk model of recessive PKD shows glutamine dependence associated with the production of the oncometabolite 2-hydroxyglutarate. Am J Physiol Renal Physiol. 2015 Sep 15; 309(6):F492-8. PMID: 26155843; PMCID: PMC4572393.
    95. Inceoglu B, Bettaieb A, Trindade da Silva CA, Lee KS, Haj FG, Hammock BD. Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):9082-7. PMID: 26150506; PMCID: PMC4517273.
    96. Ostermann AI, Herbers J, Willenberg I, Chen R, Hwang SH, Greite R, Morisseau C, Gueler F, Hammock BD, Schebb NH. Oral treatment of rodents with soluble epoxide hydrolase inhibitor 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea (TPPU): Resulting drug levels and modulation of oxylipin pattern. Prostaglandins Other Lipid Mediat. 2015 Sep; 121(Pt A):131-7. PMID: 26117215; PMCID: PMC4688279.
    97. Qin J, Sun D, Jiang H, Kandhi S, Froogh G, Hwang SH, Hammock BD, Wolin MS, Thompson CI, Hintze TH, Huang A. Inhibition of soluble epoxide hydrolase increases coronary perfusion in mice. Physiol Rep. 2015 Jun; 3(6). PMID: 26071213; PMCID: PMC4510629.
    98. Bettaieb A, Chahed S, Bachaalany S, Griffey S, Hammock BD, Haj FG. Soluble Epoxide Hydrolase Pharmacological Inhibition Ameliorates Experimental Acute Pancreatitis in Mice. Mol Pharmacol. 2015 Aug; 88(2):281-90. PMID: 25993999; PMCID: PMC4518092.
    99. Sasso O, Wagner K, Morisseau C, Inceoglu B, Hammock BD, Piomelli D. Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive. Pharmacol Res. 2015 Jul; 97:7-15. PMID: 25882247; PMCID: PMC4464910.
    100. Bruun DA, Cao Z, Inceoglu B, Vito ST, Austin AT, Hulsizer S, Hammock BD, Tancredi DJ, Rogawski MA, Pessah IN, Lein PJ. Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures. Neuropharmacology. 2015 Aug; 95:332-42. PMID: 25882826; PMCID: PMC4466064.
    101. Nording ML, Yang J, Hoang L, Zamora V, Uyeminami D, Espiritu I, Pinkerton KE, Hammock BD, Luria A. Bioactive lipid profiling reveals drug target engagement of a soluble epoxide hydrolase inhibitor in a murine model of tobacco smoke exposure. J Metabolomics. 2015 Apr; 1. PMID: 27076918.
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    102. Harris TR, Bettaieb A, Kodani S, Dong H, Myers R, Chiamvimonvat N, Haj FG, Hammock BD. Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice. Toxicol Appl Pharmacol. 2015 Jul 15; 286(2):102-11. PMID: 25827057; PMCID: PMC4458210.
    103. Kodani SD, Hammock BD. The 2014 Bernard B. Brodie award lecture-epoxide hydrolases: drug metabolism to therapeutics for chronic pain. Drug Metab Dispos. 2015 May; 43(5):788-802. PMID: 25762541; PMCID: PMC4407705.
    104. Saito Y, Kamita SG, Hammock BD, Kunimi Y, Inoue MN, Nakai M. Juvenile hormone (JH) esterase activity but not JH epoxide hydrolase activity is downregulated in larval Adoxophyes honmai following nucleopolyhedroviruses infection. J Insect Physiol. 2015 Sep; 80:71-80. PMID: 25727179.
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    105. Nollmann FI, Heinrich AK, Brachmann AO, Morisseau C, Mukherjee K, Casanova-Torres ÁM, Strobl F, Kleinhans D, Kinski S, Schultz K, Beeton ML, Kaiser M, Chu YY, Phan Ke L, Thanwisai A, Bozhüyük KA, Chantratita N, Götz F, Waterfield NR, Vilcinskas A, Stelzer EH, Goodrich-Blair H, Hammock BD, Bode HB. A Photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase. Chembiochem. 2015 Mar 23; 16(5):766-71. PMID: 25711603; PMCID: PMC4486325.
    106. Shen L, Peng H, Peng R, Fan Q, Zhao S, Xu D, Morisseau C, Chiamvimonvat N, Hammock BD. Inhibition of soluble epoxide hydrolase in mice promotes reverse cholesterol transport and regression of atherosclerosis. Atherosclerosis. 2015 Apr; 239(2):557-65. PMID: 25733327.
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    107. Xu J, Morisseau C, Yang J, Mamatha DM, Hammock BD. Epoxide hydrolase activities and epoxy fatty acids in the mosquito Culex quinquefasciatus. Insect Biochem Mol Biol. 2015 Apr; 59:41-9. PMID: 25686802; PMCID: PMC4387068.
    108. Kitamura S, Morisseau C, Inceoglu B, Kamita SG, De Nicola GR, Nyegue M, Hammock BD. Potent natural soluble epoxide hydrolase inhibitors from Pentadiplandra brazzeana baillon: synthesis, quantification, and measurement of biological activities in vitro and in vivo. PLoS One. 2015; 10(2):e0117438. PMID: 25659109; PMCID: PMC4319826.
    109. Yang J, Bratt J, Franzi L, Liu JY, Zhang G, Zeki AA, Vogel CF, Williams K, Dong H, Lin Y, Hwang SH, Kenyon NJ, Hammock BD. Soluble epoxide hydrolase inhibitor attenuates inflammation and airway hyperresponsiveness in mice. Am J Respir Cell Mol Biol. 2015 Jan; 52(1):46-55. PMID: 24922186; PMCID: PMC4370250.
    110. López-Vicario C, Alcaraz-Quiles J, García-Alonso V, Rius B, Hwang SH, Titos E, Lopategi A, Hammock BD, Arroyo V, Clària J. Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: role for omega-3 epoxides. Proc Natl Acad Sci U S A. 2015 Jan 13; 112(2):536-41. PMID: 25550510; PMCID: PMC4299190.
    111. Bettaieb A, Morisseau C, Hammock B, Haj F. Soluble epoxide hydrolase deficiency ameliorates acute pancreatitis in mice. Free Radic Biol Med. 2014 Oct; 75 Suppl 1:S32. PMID: 26461340.
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    112. Sporková A, Jíchová S, Husková Z, Kopkan L, Nishiyama A, Hwang SH, Hammock BD, Imig JD, Kompanowska-Jezierska E, Sadowski J, Kramer HJ, Cervenka L. Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: studies in Cyp1a1-Ren-2 transgenic rats. Clin Exp Pharmacol Physiol. 2014 Dec; 41(12):1003-13. PMID: 25224811; PMCID: PMC4347520.
    113. Shihadih DS, Harris TR, Yang J, Merzlikin O, Lee KS, Hammock BD, Morisseau C. Identification of potent inhibitors of the chicken soluble epoxide hydrolase. Bioorg Med Chem Lett. 2015 Jan 15; 25(2):276-9. PMID: 25479771; PMCID: PMC4277729.
    114. Wecksler AT, Hwang SH, Liu JY, Wettersten HI, Morisseau C, Wu J, Weiss RH, Hammock BD. Biological evaluation of a novel sorafenib analogue, t-CUPM. Cancer Chemother Pharmacol. 2015 Jan; 75(1):161-71. PMID: 25413440; PMCID: PMC4400119.
    115. Bettaieb A, Chahed S, Tabet G, Yang J, Morisseau C, Griffey S, Hammock BD, Haj FG. Effects of soluble epoxide hydrolase deficiency on acute pancreatitis in mice. PLoS One. 2014; 9(11):e113019. PMID: 25402489; PMCID: PMC4234494.
    116. Kim J, Yoon SP, Toews ML, Imig JD, Hwang SH, Hammock BD, Padanilam BJ. Pharmacological inhibition of soluble epoxide hydrolase prevents renal interstitial fibrogenesis in obstructive nephropathy. Am J Physiol Renal Physiol. 2015 Jan 15; 308(2):F131-9. PMID: 25377915; PMCID: PMC4338924.
    117. Chen A, Wang R, Bever CR, Xing S, Hammock BD, Pan T. Smartphone-interfaced lab-on-a-chip devices for field-deployable enzyme-linked immunosorbent assay. Biomicrofluidics. 2014 Nov; 8(6):064101. PMID: 25553178; PMCID: PMC4241779.
    118. Ono E, Dutile S, Kazani S, Wechsler ME, Yang J, Hammock BD, Douda DN, Tabet Y, Khaddaj-Mallat R, Sirois M, Sirois C, Rizcallah E, Rousseau E, Martin R, Sutherland ER, Castro M, Jarjour NN, Israel E, Levy BD. Lipoxin generation is related to soluble epoxide hydrolase activity in severe asthma. Am J Respir Crit Care Med. 2014 Oct 15; 190(8):886-97. PMID: 25162465; PMCID: PMC4299578.
    119. Vito ST, Austin AT, Banks CN, Inceoglu B, Bruun DA, Zolkowska D, Tancredi DJ, Rogawski MA, Hammock BD, Lein PJ. Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication. Toxicol Appl Pharmacol. 2014 Dec 01; 281(2):185-94. PMID: 25448683; PMCID: PMC4258121.
    120. Samokhvalov V, Zlobine I, Jamieson KL, Jurasz P, Chen C, Lee KS, Hammock BD, Seubert JM. PPARd signaling mediates the cytotoxicity of DHA in H9c2 cells. Toxicol Lett. 2015 Jan 05; 232(1):10-20. PMID: 25300478; PMCID: PMC4486642.
    121. Wagner K, Vito S, Inceoglu B, Hammock BD. The role of long chain fatty acids and their epoxide metabolites in nociceptive signaling. Prostaglandins Other Lipid Mediat. 2014 Oct; 113-115:2-12. PMID: 25240260; PMCID: PMC4254344.
    122. Terry CM, Carlson ML, He Y, Ulu A, Morisseau C, Blumenthal DK, Hammock BD, Cheung AK. Aberrant soluble epoxide hydrolase and oxylipin levels in a porcine arteriovenous graft stenosis model. J Vasc Res. 2014; 51(4):269-82. PMID: 25196102; PMCID: PMC4235611.
    123. Kim J, Imig JD, Yang J, Hammock BD, Padanilam BJ. Inhibition of soluble epoxide hydrolase prevents renal interstitial fibrosis and inflammation. Am J Physiol Renal Physiol. 2014 Oct 15; 307(8):F971-80. PMID: 25164080; PMCID: PMC4200297.
    124. Lee KS, Liu JY, Wagner KM, Pakhomova S, Dong H, Morisseau C, Fu SH, Yang J, Wang P, Ulu A, Mate CA, Nguyen LV, Hwang SH, Edin ML, Mara AA, Wulff H, Newcomer ME, Zeldin DC, Hammock BD. Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy. J Med Chem. 2014 Aug 28; 57(16):7016-30. PMID: 25079952.
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    125. Zhang G, Panigrahy D, Hwang SH, Yang J, Mahakian LM, Wettersten HI, Liu JY, Wang Y, Ingham ES, Tam S, Kieran MW, Weiss RH, Ferrara KW, Hammock BD. Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis. Proc Natl Acad Sci U S A. 2014 Jul 29; 111(30):11127-32. PMID: 25024195; PMCID: PMC4121808.
    126. Bever CR, Majkova Z, Radhakrishnan R, Suni I, McCoy M, Wang Y, Dechant J, Gee S, Hammock BD. Development and utilization of camelid VHH antibodies from alpaca for 2,2',4,4'-tetrabrominated diphenyl ether detection. Anal Chem. 2014 Aug 05; 86(15):7875-82. PMID: 25005746; PMCID: PMC4144723.
    127. Ulu A, Stephen Lee KS, Miyabe C, Yang J, Hammock BG, Dong H, Hammock BD. An omega-3 epoxide of docosahexaenoic acid lowers blood pressure in angiotensin-II-dependent hypertension. J Cardiovasc Pharmacol. 2014 Jul; 64(1):87-99. PMID: 24691274; PMCID: PMC4092041.
    128. Wagner K, Yang J, Inceoglu B, Hammock BD. Soluble epoxide hydrolase inhibition is antinociceptive in a mouse model of diabetic neuropathy. J Pain. 2014 Sep; 15(9):907-14. PMID: 24924124; PMCID: PMC4150748.
    129. Charles RL, Rudyk O, Prysyazhna O, Kamynina A, Yang J, Morisseau C, Hammock BD, Freeman BA, Eaton P. Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):8167-72. PMID: 24843165; PMCID: PMC4050620.
    130. Morisseau C, Wecksler AT, Deng C, Dong H, Yang J, Lee KS, Kodani SD, Hammock BD. Effect of soluble epoxide hydrolase polymorphism on substrate and inhibitor selectivity and dimer formation. J Lipid Res. 2014 Jun; 55(6):1131-8. PMID: 24771868; PMCID: PMC4031944.
    131. Schebb NH, Muvvala JB, Morin D, Buckpitt AR, Hammock BD, Rice RH. Metabolic activation of the antibacterial agent triclocarban by cytochrome P450 1A1 yielding glutathione adducts. Drug Metab Dispos. 2014 Jul; 42(7):1098-102. PMID: 24733789; PMCID: PMC4170114.
    132. Trunnelle KJ, Bennett DH, Ahn KC, Schenker MB, Tancredi DJ, Gee SJ, Stoecklin-Marois MT, Hammock BD. Concentrations of the urinary pyrethroid metabolite 3-phenoxybenzoic acid in farm worker families in the MICASA study. Environ Res. 2014 May; 131:153-9. PMID: 24721133; PMCID: PMC4152318.
    133. Li L, Li N, Pang W, Zhang X, Hammock BD, Ai D, Zhu Y. Opposite effects of gene deficiency and pharmacological inhibition of soluble epoxide hydrolase on cardiac fibrosis. PLoS One. 2014; 9(4):e94092. PMID: 24718617; PMCID: PMC3981766.
    134. Shrestha A, Krishnamurthy PT, Thomas P, Hammock BD, Hwang SH. Soluble epoxide hydrolase inhibitor, t-TUCB, protects against myocardial ischaemic injury in rats. J Pharm Pharmacol. 2014 Sep; 66(9):1251-8. PMID: 24697323; PMCID: PMC4134728.
    135. Wecksler AT, Hwang SH, Wettersten HI, Gilda JE, Patton A, Leon LJ, Carraway KL, Gomes AV, Baar K, Weiss RH, Hammock BD. Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB. Anticancer Drugs. 2014 Apr; 25(4):433-46. PMID: 24525589; PMCID: PMC3947856.
    136. Burmistrov V, Morisseau C, Lee KS, Shihadih DS, Harris TR, Butov GM, Hammock BD. Symmetric adamantyl-diureas as soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett. 2014 May 01; 24(9):2193-7. PMID: 24685540; PMCID: PMC4019751.
    137. Kujal P, Certíková Chábová V, Škaroupková P, Husková Z, Vernerová Z, Kramer HJ, Walkowska A, Kompanowska-Jezierska E, Sadowski J, Kitada K, Nishiyama A, Hwang SH, Hammock BD, Imig JD, Cervenka L. Inhibition of soluble epoxide hydrolase is renoprotective in 5/6 nephrectomized Ren-2 transgenic hypertensive rats. Clin Exp Pharmacol Physiol. 2014 Mar; 41(3):227-37. PMID: 24471737; PMCID: PMC4038339.
    138. Sun D, Cuevas AJ, Gotlinger K, Hwang SH, Hammock BD, Schwartzman ML, Huang A. Soluble epoxide hydrolase-dependent regulation of myogenic response and blood pressure. Am J Physiol Heart Circ Physiol. 2014 Apr 15; 306(8):H1146-53. PMID: 24561863; PMCID: PMC3989753.
    139. Kim IH, Lee IH, Nishiwaki H, Hammock BD, Nishi K. Structure-activity relationships of substituted oxyoxalamides as inhibitors of the human soluble epoxide hydrolase. Bioorg Med Chem. 2014 Feb 01; 22(3):1163-75. PMID: 24433964; PMCID: PMC4172381.
    140. Zhang G, Kodani S, Hammock BD. Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer. Prog Lipid Res. 2014 Jan; 53:108-23. PMID: 24345640; PMCID: PMC3914417.
    141. Inceoglu B, Zolkowska D, Yoo HJ, Wagner KM, Yang J, Hackett E, Hwang SH, Lee KS, Rogawski MA, Morisseau C, Hammock BD. Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures. PLoS One. 2013; 8(12):e80922. PMID: 24349022; PMCID: PMC3862847.
    142. Zhang W, Li H, Dong H, Liao J, Hammock BD, Yang GY. Soluble epoxide hydrolase deficiency inhibits dextran sulfate sodium-induced colitis and carcinogenesis in mice. Anticancer Res. 2013 Dec; 33(12):5261-5271. PMID: 24324059; PMCID: PMC4076172.
    143. Trunnelle KJ, Bennett DH, Tancredi DJ, Gee SJ, Stoecklin-Marois MT, Hennessy-Burt TE, Hammock BD, Schenker MB. Pyrethroids in house dust from the homes of farm worker families in the MICASA study. Environ Int. 2013 Nov; 61:57-63. PMID: 24096042; PMCID: PMC4059492.
    144. Gardell AM, Yang J, Sacchi R, Fangue NA, Hammock BD, Kültz D. Tilapia (Oreochromis mossambicus) brain cells respond to hyperosmotic challenge by inducing myo-inositol biosynthesis. J Exp Biol. 2013 Dec 15; 216(Pt 24):4615-25. PMID: 24072790; PMCID: PMC3851147.
    145. Shaik JS, Ahmad M, Li W, Rose ME, Foley LM, Hitchens TK, Graham SH, Hwang SH, Hammock BD, Poloyac SM. Soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is neuroprotective in rat model of ischemic stroke. Am J Physiol Heart Circ Physiol. 2013 Dec 01; 305(11):H1605-13. PMID: 24043255; PMCID: PMC3882464.
    146. Ulu A, Harris TR, Morisseau C, Miyabe C, Inoue H, Schuster G, Dong H, Iosif AM, Liu JY, Weiss RH, Chiamvimonvat N, Imig JD, Hammock BD. Anti-inflammatory effects of ?-3 polyunsaturated fatty acids and soluble epoxide hydrolase inhibitors in angiotensin-II-dependent hypertension. J Cardiovasc Pharmacol. 2013 Sep; 62(3):285-97. PMID: 23676336; PMCID: PMC3773051.
    147. Lee AR, Pechenino AS, Dong H, Hammock BD, Knowlton AA. Aging, estrogen loss and epoxyeicosatrienoic acids (EETs). PLoS One. 2013; 8(8):e70719. PMID: 23967089; PMCID: PMC3742755.
    148. Panigrahy D, Kalish BT, Huang S, Bielenberg DR, Le HD, Yang J, Edin ML, Lee CR, Benny O, Mudge DK, Butterfield CE, Mammoto A, Mammoto T, Inceoglu B, Jenkins RL, Simpson MA, Akino T, Lih FB, Tomer KB, Ingber DE, Hammock BD, Falck JR, Manthati VL, Kaipainen A, D'Amore PA, Puder M, Zeldin DC, Kieran MW. Epoxyeicosanoids promote organ and tissue regeneration. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13528-33. PMID: 23898174; PMCID: PMC3746918.
    149. Ranganathan A, Paradise GA, Hansen CA, McCoy MR, Gee SJ, Zhong P, Chang D, Hammock BD. Indirect homologous competitive enzyme-linked immunosorbent assay for the detection of a class of glycosylated dihydrochalcones. J Agric Food Chem. 2013 Jul 17; 61(28):6964-70. PMID: 23767873; PMCID: PMC3723731.
    150. Smilowitz JT, Zivkovic AM, Wan YJ, Watkins SM, Nording ML, Hammock BD, German JB. Nutritional lipidomics: molecular metabolism, analytics, and diagnostics. Mol Nutr Food Res. 2013 Aug; 57(8):1319-35. PMID: 23818328; PMCID: PMC3806310.
    151. Kamita SG, Oshita GH, Wang P, Morisseau C, Hammock BD, Nandety RS, Falk BW. Characterization of Hovi-mEH1, a microsomal epoxide hydrolase from the glassy-winged sharpshooter Homalodisca vitripennis. Arch Insect Biochem Physiol. 2013 Aug; 83(4):171-9. PMID: 23704009; PMCID: PMC3846607.
    152. Harris TR, Hammock BD. Soluble epoxide hydrolase: gene structure, expression and deletion. Gene. 2013 Sep 10; 526(2):61-74. PMID: 23701967; PMCID: PMC3733540.
    153. Hwang SH, Wecksler AT, Zhang G, Morisseau C, Nguyen LV, Fu SH, Hammock BD. Synthesis and biological evaluation of sorafenib- and regorafenib-like sEH inhibitors. Bioorg Med Chem Lett. 2013 Jul 01; 23(13):3732-7. PMID: 23726028; PMCID: PMC3744640.
    154. Morisseau C, Pakhomova S, Hwang SH, Newcomer ME, Hammock BD. Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides. Bioorg Med Chem Lett. 2013 Jul 01; 23(13):3818-21. PMID: 23684894; PMCID: PMC3703951.
    155. Poli G, Corda E, Martino PA, Dall'ara P, Bareggi SR, Bondiolotti G, Iulini B, Mazza M, Casalone C, Hwang SH, Hammock BD, Inceoglu B. Therapeutic activity of inhibition of the soluble epoxide hydrolase in a mouse model of scrapie. Life Sci. 2013 Jun 21; 92(23):1145-50. PMID: 23651659; PMCID: PMC3806320.
    156. Bettaieb A, Nagata N, AbouBechara D, Chahed S, Morisseau C, Hammock BD, Haj FG. Soluble epoxide hydrolase deficiency or inhibition attenuates diet-induced endoplasmic reticulum stress in liver and adipose tissue. J Biol Chem. 2013 May 17; 288(20):14189-99. PMID: 23576437; PMCID: PMC3656275.
    157. Zhang G, Panigrahy D, Mahakian LM, Yang J, Liu JY, Stephen Lee KS, Wettersten HI, Ulu A, Hu X, Tam S, Hwang SH, Ingham ES, Kieran MW, Weiss RH, Ferrara KW, Hammock BD. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6530-5. PMID: 23553837; PMCID: PMC3631682.
    158. Althurwi HN, Tse MM, Abdelhamid G, Zordoky BN, Hammock BD, El-Kadi AO. Soluble epoxide hydrolase inhibitor, TUPS, protects against isoprenaline-induced cardiac hypertrophy. Br J Pharmacol. 2013 Apr; 168(8):1794-807. PMID: 23176298; PMCID: PMC3623051.
    159. Varcabova S, Huskova Z, Kramer HJ, Hwang SH, Hammock BD, Imig JD, Kitada K, Cervenka L. Antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats is mediated by suppression of the intrarenal renin-angiotensin system. Clin Exp Pharmacol Physiol. 2013 Apr; 40(4):273-81. PMID: 23039246; PMCID: PMC3769696.
    160. Sirish P, Li N, Liu JY, Lee KS, Hwang SH, Qiu H, Zhao C, Ma SM, López JE, Hammock BD, Chiamvimonvat N. Unique mechanistic insights into the beneficial effects of soluble epoxide hydrolase inhibitors in the prevention of cardiac fibrosis. Proc Natl Acad Sci U S A. 2013 Apr 02; 110(14):5618-23. PMID: 23493561; PMCID: PMC3619365.
    161. Han JH, Kim HJ, Sudheendra L, Gee SJ, Hammock BD, Kennedy IM. Photonic crystal lab-on-a-chip for detecting staphylococcal enterotoxin B at low attomolar concentration. Anal Chem. 2013 Mar 19; 85(6):3104-9. PMID: 23418954; PMCID: PMC3608201.
    162. Guedes AG, Morisseau C, Sole A, Soares JH, Ulu A, Dong H, Hammock BD. Use of a soluble epoxide hydrolase inhibitor as an adjunctive analgesic in a horse with laminitis. Vet Anaesth Analg. 2013 Jul; 40(4):440-8. PMID: 23463912; PMCID: PMC3956586.
    163. Stewart DN, Lango J, Nambiar KP, Falso MJ, FitzGerald PG, Rocke DM, Hammock BD, Buchholz BA. Carbon turnover in the water-soluble protein of the adult human lens. Mol Vis. 2013; 19:463-75. PMID: 23441119; PMCID: PMC3580966.
    164. Honetschlägerová Z, Kitada K, Husková Z, Sporková A, Kopkan L, Bürgelová M, Varcabová Š, Nishiyama A, Hwang SH, Hammock BD, Imig JD, Kramer HJ, Kujal P, Vernerová Z, Cervenka L. Antihypertensive and renoprotective actions of soluble epoxide hydrolase inhibition in ANG II-dependent malignant hypertension are abolished by pretreatment with L-NAME. J Hypertens. 2013 Feb; 31(2):321-32. PMID: 23307303; PMCID: PMC3773167.
    165. Liu JY, Lin YP, Qiu H, Morisseau C, Rose TE, Hwang SH, Chiamvimonvat N, Hammock BD. Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models. Eur J Pharm Sci. 2013 Mar 12; 48(4-5):619-27. PMID: 23291046; PMCID: PMC3596469.
    166. Yang J, Solaimani P, Dong H, Hammock B, Hankinson O. Treatment of mice with 2,3,7,8-Tetrachlorodibenzo-p-dioxin markedly increases the levels of a number of cytochrome P450 metabolites of omega-3 polyunsaturated fatty acids in the liver and lung. J Toxicol Sci. 2013; 38(6):833-6. PMID: 24213002; PMCID: PMC4068614.
    167. Kamita SG, Yamamoto K, Dadala MM, Pha K, Morisseau C, Escaich A, Hammock BD. Cloning and characterization of a microsomal epoxide hydrolase from Heliothis virescens. Insect Biochem Mol Biol. 2013 Mar; 43(3):219-28. PMID: 23276675; PMCID: PMC3577957.
    168. Wagner K, Inceoglu B, Dong H, Yang J, Hwang SH, Jones P, Morisseau C, Hammock BD. Comparative efficacy of 3 soluble epoxide hydrolase inhibitors in rat neuropathic and inflammatory pain models. Eur J Pharmacol. 2013 Jan 30; 700(1-3):93-101. PMID: 23276668; PMCID: PMC3578047.
    169. Chen L, Fan C, Zhang Y, Bakri M, Dong H, Morisseau C, Maddipati KR, Luo P, Wang CY, Hammock BD, Wang MH. Beneficial effects of inhibition of soluble epoxide hydrolase on glucose homeostasis and islet damage in a streptozotocin-induced diabetic mouse model. Prostaglandins Other Lipid Mediat. 2013 Jul-Aug; 104-105:42-8. PMID: 23247129; PMCID: PMC4052893.
    170. Lee KS, Morisseau C, Yang J, Wang P, Hwang SH, Hammock BD. Förster resonance energy transfer competitive displacement assay for human soluble epoxide hydrolase. Anal Biochem. 2013 Mar 15; 434(2):259-68. PMID: 23219719; PMCID: PMC3632402.
    171. Morisseau C, Sahdeo S, Cortopassi G, Hammock BD. Development of an HTS assay for EPHX2 phosphatase activity and screening of nontargeted libraries. Anal Biochem. 2013 Mar 01; 434(1):105-11. PMID: 23219563; PMCID: PMC3557602.
    172. Pecic S, Pakhomova S, Newcomer ME, Morisseau C, Hammock BD, Zhu Z, Rinderspacher A, Deng SX. Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett. 2013 Jan 15; 23(2):417-21. PMID: 23237835; PMCID: PMC3541548.
    173. Imig JD, Walsh KA, Hye Khan MA, Nagasawa T, Cherian-Shaw M, Shaw SM, Hammock BD. Soluble epoxide hydrolase inhibition and peroxisome proliferator activated receptor ? agonist improve vascular function and decrease renal injury in hypertensive obese rats. Exp Biol Med (Maywood). 2012 Dec; 237(12):1402-12. PMID: 23354399; PMCID: PMC3613242.
    174. Zivkovic AM, Yang J, Georgi K, Hegedus C, Nording ML, O'Sullivan A, German JB, Hogg RJ, Weiss RH, Bay C, Hammock BD. Serum oxylipin profiles in IgA nephropathy patients reflect kidney functional alterations. Metabolomics. 2012 Dec; 8(6):1102-1113. PMID: 23833568.
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    175. Kundu S, Roome T, Bhattacharjee A, Carnevale KA, Yakubenko VP, Zhang R, Hwang SH, Hammock BD, Cathcart MK. Metabolic products of soluble epoxide hydrolase are essential for monocyte chemotaxis to MCP-1 in vitro and in vivo. J Lipid Res. 2013 Feb; 54(2):436-47. PMID: 23160182; PMCID: PMC3588870.
    176. Wang Q, Pang W, Cui Z, Shi J, Liu Y, Liu B, Zhou Y, Guan Y, Hammock BD, Wang Y, Zhu Y. Upregulation of soluble epoxide hydrolase in proximal tubular cells mediated proteinuria-induced renal damage. Am J Physiol Renal Physiol. 2013 Jan 15; 304(2):F168-76. PMID: 23152298; PMCID: PMC3543623.
    177. Falck D, Schebb NH, Prihatiningtyas S, Zhang J, Heus F, Morisseau C, Kool J, Hammock BD, Niessen WM. Development of On-line Liquid Chromatography-Biochemical Detection for Soluble Epoxide Hydrolase Inhibitors in Mixtures. Chromatographia. 2013 Jan 01; 76(1-2):13-21. PMID: 23526703.
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    178. Morisseau C, Hammock BD. Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health. Annu Rev Pharmacol Toxicol. 2013; 53:37-58. PMID: 23020295; PMCID: PMC3578707.
    179. Huang H, Yao H, Liu JY, Samra AI, Kamita SG, Cornel AJ, Hammock BD. Development of pyrethroid-like fluorescent substrates for glutathione S-transferase. Anal Biochem. 2012 Dec 15; 431(2):77-83. PMID: 23000005; PMCID: PMC3489985.
    180. Han JH, Sudheendra L, Kim HJ, Gee SJ, Hammock BD, Kennedy IM. Ultrasensitive on-chip immunoassays with a nanoparticle-assembled photonic crystal. ACS Nano. 2012 Oct 23; 6(10):8570-82. PMID: 22957818; PMCID: PMC3479307.
    181. Han JH, Kim HJ, Sudheendra L, Hass EA, Gee SJ, Hammock BD, Kennedy IM. Electrophoretic build-up of multi nanoparticle array for a highly sensitive immunoassay. Biosens Bioelectron. 2013 Mar 15; 41:302-8. PMID: 23021853; PMCID: PMC3525773.
    182. Kopkan L, Husková Z, Sporková A, Varcabová Š, Honetschlägerová Z, Hwang SH, Tsai HJ, Hammock BD, Imig JD, Kramer HJ, Bürgelová M, Vojtíšková A, Kujal P, Vernerová Z, Cervenka L. Soluble epoxide hydrolase inhibition exhibits antihypertensive actions independently of nitric oxide in mice with renovascular hypertension. Kidney Blood Press Res. 2012; 35(6):595-607. PMID: 22948718; PMCID: PMC3604982.
    183. Cao Z, Hammock BD, McCoy M, Rogawski MA, Lein PJ, Pessah IN. Tetramethylenedisulfotetramine alters Ca²? dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation. Toxicol Sci. 2012 Dec; 130(2):362-72. PMID: 22889812; PMCID: PMC3529644.
    184. Cherednichenko G, Zhang R, Bannister RA, Timofeyev V, Li N, Fritsch EB, Feng W, Barrientos GC, Schebb NH, Hammock BD, Beam KG, Chiamvimonvat N, Pessah IN. Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14158-63. PMID: 22891308; PMCID: PMC3435154.
    185. Guglielmino K, Jackson K, Harris TR, Vu V, Dong H, Dutrow G, Evans JE, Graham J, Cummings BP, Havel PJ, Chiamvimonvat N, Despa S, Hammock BD, Despa F. Pharmacological inhibition of soluble epoxide hydrolase provides cardioprotection in hyperglycemic rats. Am J Physiol Heart Circ Physiol. 2012 Oct 01; 303(7):H853-62. PMID: 22865388; PMCID: PMC3469704.
    186. Kim IH, Nishi K, Kasagami T, Morisseau C, Liu JY, Tsai HJ, Hammock BD. Biologically active ester derivatives as potent inhibitors of the soluble epoxide hydrolase. Bioorg Med Chem Lett. 2012 Sep 15; 22(18):5889-92. PMID: 22901393; PMCID: PMC3432147.
    187. Decker M, Adamska M, Cronin A, Di Giallonardo F, Burgener J, Marowsky A, Falck JR, Morisseau C, Hammock BD, Gruzdev A, Zeldin DC, Arand M. EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides. J Lipid Res. 2012 Oct; 53(10):2038-45. PMID: 22798687; PMCID: PMC3435537.
    188. Inceoglu AB, Clifton HL, Yang J, Hegedus C, Hammock BD, Schaefer S. Inhibition of soluble epoxide hydrolase limits niacin-induced vasodilation in mice. J Cardiovasc Pharmacol. 2012 Jul; 60(1):70-5. PMID: 22526297; PMCID: PMC3396292.
    189. Inceoglu B, Wagner KM, Yang J, Bettaieb A, Schebb NH, Hwang SH, Morisseau C, Haj FG, Hammock BD. Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of type I diabetes. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11390-5. PMID: 22733772; PMCID: PMC3396532.
    190. Qiu H, Liu JY, Wei D, Li N, Yamoah EN, Hammock BD, Chiamvimonvat N. Cardiac-generated prostanoids mediate cardiac myocyte apoptosis after myocardial ischaemia. Cardiovasc Res. 2012 Aug 01; 95(3):336-45. PMID: 22707158; PMCID: PMC3400359.
    191. Liu Y, Dang H, Li D, Pang W, Hammock BD, Zhu Y. Inhibition of soluble epoxide hydrolase attenuates high-fat-diet-induced hepatic steatosis by reduced systemic inflammatory status in mice. PLoS One. 2012; 7(6):e39165. PMID: 22720061; PMCID: PMC3375303.
    192. Frömel T, Jungblut B, Hu J, Trouvain C, Barbosa-Sicard E, Popp R, Liebner S, Dimmeler S, Hammock BD, Fleming I. Soluble epoxide hydrolase regulates hematopoietic progenitor cell function via generation of fatty acid diols. Proc Natl Acad Sci U S A. 2012 Jun 19; 109(25):9995-10000. PMID: 22665795; PMCID: PMC3382493.
    193. Neckár J, Kopkan L, Husková Z, Kolár F, Papoušek F, Kramer HJ, Hwang SH, Hammock BD, Imig JD, Malý J, Netuka I, Oštádal B, Cervenka L. Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension. Clin Sci (Lond). 2012 Jun; 122(11):513-25. PMID: 22324471; PMCID: PMC3528350.
    194. Lin Y, Ubels JL, Schotanus MP, Yin Z, Pintea V, Hammock BD, Watsky MA. Enhancement of vitamin D metabolites in the eye following vitamin D3 supplementation and UV-B irradiation. Curr Eye Res. 2012 Oct; 37(10):871-8. PMID: 22632164; PMCID: PMC3572765.
    195. Sanders WG, Morisseau C, Hammock BD, Cheung AK, Terry CM. Soluble epoxide hydrolase expression in a porcine model of arteriovenous graft stenosis and anti-inflammatory effects of a soluble epoxide hydrolase inhibitor. Am J Physiol Cell Physiol. 2012 Aug 01; 303(3):C278-90. PMID: 22621785; PMCID: PMC3423029.
    196. Stephensen CB, Zerofsky M, Burnett DJ, Lin YP, Hammock BD, Hall LM, McHugh T. Ergocalciferol from mushrooms or supplements consumed with a standard meal increases 25-hydroxyergocalciferol but decreases 25-hydroxycholecalciferol in the serum of healthy adults. J Nutr. 2012 Jul; 142(7):1246-52. PMID: 22623385.
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    197. Zhang W, Yang AL, Liao J, Li H, Dong H, Chung YT, Bai H, Matkowskyj KA, Hammock BD, Yang GY. Soluble epoxide hydrolase gene deficiency or inhibition attenuates chronic active inflammatory bowel disease in IL-10(-/-) mice. Dig Dis Sci. 2012 Oct; 57(10):2580-91. PMID: 22588244; PMCID: PMC3664520.
    198. McCoy MR, Yang Z, Fu X, Ahn KC, Gee SJ, Bom DC, Zhong P, Chang D, Hammock BD. Monitoring of total type ii pyrethroid pesticides in citrus oils and water by converting to a common product 3-phenoxybenzoic acid. J Agric Food Chem. 2012 May 23; 60(20):5065-70. PMID: 22486225; PMCID: PMC3412423.
    199. Yang J, Eiserich JP, Cross CE, Morrissey BM, Hammock BD. Metabolomic profiling of regulatory lipid mediators in sputum from adult cystic fibrosis patients. Free Radic Biol Med. 2012 Jul 01; 53(1):160-71. PMID: 22580336; PMCID: PMC3412514.
    200. Xu DY, Davis BB, Wang ZH, Zhao SP, Wasti B, Liu ZL, Li N, Morisseau C, Chiamvimonvat N, Hammock BD. A potent soluble epoxide hydrolase inhibitor, t-AUCB, acts through PPAR? to modulate the function of endothelial progenitor cells from patients with acute myocardial infarction. Int J Cardiol. 2013 Aug 20; 167(4):1298-304. PMID: 22525341; PMCID: PMC3821736.
    201. Zhang W, Liao J, Li H, Dong H, Bai H, Yang A, Hammock BD, Yang GY. Reduction of inflammatory bowel disease-induced tumor development in IL-10 knockout mice with soluble epoxide hydrolase gene deficiency. Mol Carcinog. 2013 Sep; 52(9):726-38. PMID: 22517541; PMCID: PMC3407328.
    202. Huang SX, Cao B, Morisseau C, Jin Y, Hammock BD, Long YQ. Structure-based optimization of the piperazino-containing 1,3-disubstituted ureas affording sub-nanomolar inhibitors of soluble epoxide hydrolase. Medchemcomm. 2012 Mar 01; (3):379-384. PMID: 25225606.
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    203. Morisseau C, Schebb NH, Dong H, Ulu A, Aronov PA, Hammock BD. Role of soluble epoxide hydrolase phosphatase activity in the metabolism of lysophosphatidic acids. Biochem Biophys Res Commun. 2012 Mar 23; 419(4):796-800. PMID: 22387545; PMCID: PMC3313618.
    204. Zhang D, Xie X, Chen Y, Hammock BD, Kong W, Zhu Y. Homocysteine upregulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. Circ Res. 2012 Mar 16; 110(6):808-17. PMID: 22354938; PMCID: PMC3514454.
    205. Zolkowska D, Banks CN, Dhir A, Inceoglu B, Sanborn JR, McCoy MR, Bruun DA, Hammock BD, Lein PJ, Rogawski MA. Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine. J Pharmacol Exp Ther. 2012 May; 341(2):435-46. PMID: 22328574.
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    206. Samra AI, Kamita SG, Yao HW, Cornel AJ, Hammock BD. Cloning and characterization of two glutathione S-transferases from pyrethroid-resistant Culex pipiens. Pest Manag Sci. 2012 May; 68(5):764-72. PMID: 22290868; PMCID: PMC3583349.
    207. Shen HC, Hammock BD. Discovery of inhibitors of soluble epoxide hydrolase: a target with multiple potential therapeutic indications. J Med Chem. 2012 Mar 08; 55(5):1789-808. PMID: 22168898; PMCID: PMC3420824.
    208. Kim HJ, McCoy MR, Majkova Z, Dechant JE, Gee SJ, Tabares-da Rosa S, González-Sapienza GG, Hammock BD. Isolation of alpaca anti-hapten heavy chain single domain antibodies for development of sensitive immunoassay. Anal Chem. 2012 Jan 17; 84(2):1165-71. PMID: 22148739; PMCID: PMC3264785.
    209. Wang L, Yang J, Guo L, Uyeminami D, Dong H, Hammock BD, Pinkerton KE. Use of a soluble epoxide hydrolase inhibitor in smoke-induced chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2012 May; 46(5):614-22. PMID: 22180869; PMCID: PMC3359909.
    210. Villalon Landeros R, Morisseau C, Yoo HJ, Fu SH, Hammock BD, Trainor BC. Corncob bedding alters the effects of estrogens on aggressive behavior and reduces estrogen receptor-a expression in the brain. Endocrinology. 2012 Feb; 153(2):949-53. PMID: 22186416; PMCID: PMC3275391.
    211. Ahn KC, Kasagami T, Tsai HJ, Schebb NH, Ogunyoku T, Gee SJ, Young TM, Hammock BD. An immunoassay to evaluate human/environmental exposure to the antimicrobial triclocarban. Environ Sci Technol. 2012 Jan 03; 46(1):374-81. PMID: 22077920; PMCID: PMC3258304.
    212. Hou HH, Hammock BD, Su KH, Morisseau C, Kou YR, Imaoka S, Oguro A, Shyue SK, Zhao JF, Lee TS. N-terminal domain of soluble epoxide hydrolase negatively regulates the VEGF-mediated activation of endothelial nitric oxide synthase. Cardiovasc Res. 2012 Jan 01; 93(1):120-9. PMID: 22072631; PMCID: PMC3243038.
    213. Pecic S, Deng SX, Morisseau C, Hammock BD, Landry DW. Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett. 2012 Jan 01; 22(1):601-5. PMID: 22079754; PMCID: PMC3337727.
    214. Iyer A, Kauter K, Alam MA, Hwang SH, Morisseau C, Hammock BD, Brown L. Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats. Exp Diabetes Res. 2012; 2012:758614. PMID: 22007192; PMCID: PMC3191770.
    215. Hammock BD, Wagner K, Inceoglu B. The soluble epoxide hydrolase as a pharmaceutical target for pain management. Pain Manag. 2011 Sep; 1(5):383-6. PMID: 24645702.
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    216. Wagner K, Inceoglu B, Hammock BD. Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception. Prostaglandins Other Lipid Mediat. 2011 Nov; 96(1-4):76-83. PMID: 21854866; PMCID: PMC3215909.
    217. Honetschlägerová Z, Sporková A, Kopkan L, Husková Z, Hwang SH, Hammock BD, Imig JD, Kramer HJ, Kujal P, Vernerová Z, Chábová VC, Tesar V, Cervenka L. Inhibition of soluble epoxide hydrolase improves the impaired pressure-natriuresis relationship and attenuates the development of hypertension and hypertension-associated end-organ damage in Cyp1a1-Ren-2 transgenic rats. J Hypertens. 2011 Aug; 29(8):1590-601. PMID: 21720266; PMCID: PMC3777565.
    218. Ahn KC, Gee SJ, Kim HJ, Aronov PA, Vega H, Krieger RI, Hammock BD. Immunochemical analysis of 3-phenoxybenzoic acid, a biomarker of forestry worker exposure to pyrethroid insecticides. Anal Bioanal Chem. 2011 Sep; 401(4):1285-93. PMID: 21717113; PMCID: PMC3848323.
    219. Liu JY, Qiu H, Morisseau C, Hwang SH, Tsai HJ, Ulu A, Chiamvimonvat N, Hammock BD. Inhibition of soluble epoxide hydrolase contributes to the anti-inflammatory effect of antimicrobial triclocarban in a murine model. Toxicol Appl Pharmacol. 2011 Sep 01; 255(2):200-6. PMID: 21741984; PMCID: PMC3156297.
    220. Davis BB, Liu JY, Tancredi DJ, Wang L, Simon SI, Hammock BD, Pinkerton KE. The anti-inflammatory effects of soluble epoxide hydrolase inhibitors are independent of leukocyte recruitment. Biochem Biophys Res Commun. 2011 Jul 08; 410(3):494-500. PMID: 21683067; PMCID: PMC3166856.
    221. Yang J, Dong H, Hammock BD. Profiling the regulatory lipids: another systemic way to unveil the biological mystery. Curr Opin Lipidol. 2011 Jun; 22(3):197-203. PMID: 21537174; PMCID: PMC3498048.
    222. Liu X, Li C, Gebremedhin D, Hwang SH, Hammock BD, Falck JR, Roman RJ, Harder DR, Koehler RC. Epoxyeicosatrienoic acid-dependent cerebral vasodilation evoked by metabotropic glutamate receptor activation in vivo. Am J Physiol Heart Circ Physiol. 2011 Aug; 301(2):H373-81. PMID: 21602473; PMCID: PMC3154671.
    223. Luria A, Bettaieb A, Xi Y, Shieh GJ, Liu HC, Inoue H, Tsai HJ, Imig JD, Haj FG, Hammock BD. Soluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistance. Proc Natl Acad Sci U S A. 2011 May 31; 108(22):9038-43. PMID: 21571638; PMCID: PMC3107315.
    224. Schebb NH, Huby M, Morisseau C, Hwang SH, Hammock BD. Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors. Anal Bioanal Chem. 2011 May; 400(5):1359-66. PMID: 21479549; PMCID: PMC3081056.
    225. Hwang SH, Wagner KM, Morisseau C, Liu JY, Dong H, Wecksler AT, Hammock BD. Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase. J Med Chem. 2011 Apr 28; 54(8):3037-50. PMID: 21434686; PMCID: PMC3281519.
    226. Qiu H, Li N, Liu JY, Harris TR, Hammock BD, Chiamvimonvat N. Soluble epoxide hydrolase inhibitors and heart failure. Cardiovasc Ther. 2011 Apr; 29(2):99-111. PMID: 20433684.
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    227. Inceoglu B, Wagner K, Schebb NH, Morisseau C, Jinks SL, Ulu A, Hegedus C, Rose T, Brosnan R, Hammock BD. Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP. Proc Natl Acad Sci U S A. 2011 Mar 22; 108(12):5093-7. PMID: 21383170; PMCID: PMC3064364.
    228. Schebb NH, Inceoglu B, Ahn KC, Morisseau C, Gee SJ, Hammock BD. Investigation of human exposure to triclocarban after showering and preliminary evaluation of its biological effects. Environ Sci Technol. 2011 Apr 01; 45(7):3109-15. PMID: 21381656; PMCID: PMC3470465.
    229. Morisseau C, Bernay M, Escaich A, Sanborn JR, Lango J, Hammock BD. Development of fluorescent substrates for microsomal epoxide hydrolase and application to inhibition studies. Anal Biochem. 2011 Jul 01; 414(1):154-62. PMID: 21371418; PMCID: PMC3090455.
    230. Aboutabl ME, Zordoky BN, Hammock BD, El-Kadi AO. Inhibition of soluble epoxide hydrolase confers cardioprotection and prevents cardiac cytochrome P450 induction by benzo(a)pyrene. J Cardiovasc Pharmacol. 2011 Mar; 57(3):273-81. PMID: 21383588.
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    231. Kim IH, Park YK, Hammock BD, Nishi K. Structure-activity relationships of cycloalkylamide derivatives as inhibitors of the soluble epoxide hydrolase. J Med Chem. 2011 Mar 24; 54(6):1752-61. PMID: 21338111; PMCID: PMC3517215.
    232. Koeners MP, Wesseling S, Ulu A, Sepúlveda RL, Morisseau C, Braam B, Hammock BD, Joles JA. Soluble epoxide hydrolase in the generation and maintenance of high blood pressure in spontaneously hypertensive rats. Am J Physiol Endocrinol Metab. 2011 Apr; 300(4):E691-8. PMID: 21266668; PMCID: PMC3074945.
    233. Abdu E, Bruun DA, Yang D, Yang J, Inceoglu B, Hammock BD, Alkayed NJ, Lein PJ. Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures. J Neurochem. 2011 May; 117(4):632-42. PMID: 21155804; PMCID: PMC3081369.
    234. Honetschlägerová Z, Husková Z, Vanourková Z, Sporková A, Kramer HJ, Hwang SH, Tsai HJ, Hammock BD, Imig JD, Cervenka L, Kopkan L. Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats with inducible hypertension. J Physiol. 2011 Jan 01; 589(Pt 1):207-19. PMID: 21078594; PMCID: PMC3039270.
    235. Schebb NH, Inceoglu B, Rose T, Wagner K, Hammock BD. Development of an ultra fast online-solid phase extraction (SPE) liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS) based approach for the determination of drugs in pharmacokinetic studies. Anal Methods. 2011 Jan 01; 3(2):420-428. PMID: 21660124.
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    236. Charles RL, Burgoyne JR, Mayr M, Weldon SM, Hubner N, Dong H, Morisseau C, Hammock BD, Landar A, Eaton P. Redox regulation of soluble epoxide hydrolase by 15-deoxy-delta-prostaglandin J2 controls coronary hypoxic vasodilation. Circ Res. 2011 Feb 04; 108(3):324-34. PMID: 21164107.
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    237. Anandan SK, Webb HK, Chen D, Wang YX, Aavula BR, Cases S, Cheng Y, Do ZN, Mehra U, Tran V, Vincelette J, Waszczuk J, White K, Wong KR, Zhang LN, Jones PD, Hammock BD, Patel DV, Whitcomb R, MacIntyre DE, Sabry J, Gless R. 1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia. Bioorg Med Chem Lett. 2011 Feb 01; 21(3):983-8. PMID: 21211973; PMCID: PMC3529200.
    238. Kim HJ, McCoy M, Gee SJ, González-Sapienza GG, Hammock BD. Noncompetitive phage anti-immunocomplex real-time polymerase chain reaction for sensitive detection of small molecules. Anal Chem. 2011 Jan 01; 83(1):246-53. PMID: 21141939; PMCID: PMC3031424.
    239. Ahn KC, Kim HJ, McCoy MR, Gee SJ, Hammock BD. Immunoassays and biosensors for monitoring environmental and human exposure to pyrethroid insecticides. J Agric Food Chem. 2011 Apr 13; 59(7):2792-802. PMID: 21105656; PMCID: PMC3070843.
    240. Huang SX, Li HY, Liu JY, Morisseau C, Hammock BD, Long YQ. Incorporation of piperazino functionality into 1,3-disubstituted urea as the tertiary pharmacophore affording potent inhibitors of soluble epoxide hydrolase with improved pharmacokinetic properties. J Med Chem. 2010 Dec 09; 53(23):8376-86. PMID: 21070033.
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    241. Wagner K, Inceoglu B, Gill SS, Hammock BD. Epoxygenated fatty acids and soluble epoxide hydrolase inhibition: novel mediators of pain reduction. J Agric Food Chem. 2011 Apr 13; 59(7):2816-24. PMID: 20958046; PMCID: PMC3483885.
    242. Rose TE, Morisseau C, Liu JY, Inceoglu B, Jones PD, Sanborn JR, Hammock BD. 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain. J Med Chem. 2010 Oct 14; 53(19):7067-75. PMID: 20812725; PMCID: PMC3285450.
    243. Zhang D, Ai D, Tanaka H, Hammock BD, Zhu Y. DNA methylation of the promoter of soluble epoxide hydrolase silences its expression by an SP-1-dependent mechanism. Biochim Biophys Acta. 2010 Sep; 1799(9):659-67. PMID: 20888937.
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    244. Liu JY, Li N, Yang J, Li N, Qiu H, Ai D, Chiamvimonvat N, Zhu Y, Hammock BD. Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovascular events. Proc Natl Acad Sci U S A. 2010 Sep 28; 107(39):17017-22. PMID: 20837537; PMCID: PMC2947894.
    245. Jung O, Jansen F, Mieth A, Barbosa-Sicard E, Pliquett RU, Babelova A, Morisseau C, Hwang SH, Tsai C, Hammock BD, Schaefer L, Geisslinger G, Amann K, Brandes RP. Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease. PLoS One. 2010 Aug 04; 5(8):e11979. PMID: 20694143; PMCID: PMC2915917.
    246. Morisseau C, Inceoglu B, Schmelzer K, Tsai HJ, Jinks SL, Hegedus CM, Hammock BD. Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids. J Lipid Res. 2010 Dec; 51(12):3481-90. PMID: 20664072; PMCID: PMC2975720.
    247. Norwood S, Liao J, Hammock BD, Yang GY. Epoxyeicosatrienoic acids and soluble epoxide hydrolase: potential therapeutic targets for inflammation and its induced carcinogenesis. Am J Transl Res. 2010 Jul 22; 2(4):447-57. PMID: 20733953; PMCID: PMC2923867.
    248. Kamita SG, Hammock BD. Juvenile hormone esterase: biochemistry and structure. J Pestic Sci. 2010 Aug 31; 35(3):265-274. PMID: 23543805.
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    249. Kamita SG, Wogulis MD, Law CS, Morisseau C, Tanaka H, Huang H, Wilson DK, Hammock BD. Function of phenylalanine 259 and threonine 314 within the substrate binding pocket of the juvenile hormone esterase of Manduca sexta. Biochemistry. 2010 May 04; 49(17):3733-42. PMID: 20307057; PMCID: PMC3570046.
    250. Luo P, Chang HH, Zhou Y, Zhang S, Hwang SH, Morisseau C, Wang CY, Inscho EW, Hammock BD, Wang MH. Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis. J Pharmacol Exp Ther. 2010 Aug; 334(2):430-8. PMID: 20439437; PMCID: PMC2913776.
    251. Wang YX, Ulu A, Zhang LN, Hammock B. Soluble epoxide hydrolase in atherosclerosis. Curr Atheroscler Rep. 2010 May; 12(3):174-83. PMID: 20425256; PMCID: PMC2857794.
    252. Tsai HJ, Hwang SH, Morisseau C, Yang J, Jones PD, Kasagami T, Kim IH, Hammock BD. Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs. Eur J Pharm Sci. 2010 Jun 14; 40(3):222-38. PMID: 20359531; PMCID: PMC3285443.
    253. Revermann M, Schloss M, Barbosa-Sicard E, Mieth A, Liebner S, Morisseau C, Geisslinger G, Schermuly RT, Fleming I, Hammock BD, Brandes RP. Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice. Arterioscler Thromb Vasc Biol. 2010 May; 30(5):909-14. PMID: 20224052; PMCID: PMC2919323.
    254. Alihosseini F, Lango J, Ju KS, Hammock BD, Sun G. Mutation of bacterium Vibrio gazogenes for selective preparation of colorants. Biotechnol Prog. 2010 Mar-Apr; 26(2):352-60. PMID: 19902486; PMCID: PMC2864118.
    255. Kubala L, Schmelzer KR, Klinke A, Kolarova H, Baldus S, Hammock BD, Eiserich JP. Modulation of arachidonic and linoleic acid metabolites in myeloperoxidase-deficient mice during acute inflammation. Free Radic Biol Med. 2010 May 15; 48(10):1311-20. PMID: 20156554; PMCID: PMC2856720.
    256. Kim HJ, Rossotti MA, Ahn KC, González-Sapienza GG, Gee SJ, Musker R, Hammock BD. Development of a noncompetitive phage anti-immunocomplex assay for brominated diphenyl ether 47. Anal Biochem. 2010 Jun 01; 401(1):38-46. PMID: 20152791; PMCID: PMC2861364.
    257. Bahl CD, Morisseau C, Bomberger JM, Stanton BA, Hammock BD, O'Toole GA, Madden DR. Crystal structure of the cystic fibrosis transmembrane conductance regulator inhibitory factor Cif reveals novel active-site features of an epoxide hydrolase virulence factor. J Bacteriol. 2010 Apr; 192(7):1785-95. PMID: 20118260; PMCID: PMC2838060.
    258. Hall LM, Kimlin MG, Aronov PA, Hammock BD, Slusser JR, Woodhouse LR, Stephensen CB. Vitamin D intake needed to maintain target serum 25-hydroxyvitamin D concentrations in participants with low sun exposure and dark skin pigmentation is substantially higher than current recommendations. J Nutr. 2010 Mar; 140(3):542-50. PMID: 20053937; PMCID: PMC2821886.
    259. Nording ML, Yang J, Hegedus CM, Bhushan A, Kenyon NJ, Davis CE, Hammock BD. Endogenous Levels of Five Fatty Acid Metabolites in Exhaled Breath Condensate to Monitor Asthma by High-Performance Liquid Chromatography: Electrospray Tandem Mass Spectrometry. IEEE Sens J. 2010 Jan 01; 10(1):123-130. PMID: 21103452.
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    260. Chaudhary KR, Abukhashim M, Hwang SH, Hammock BD, Seubert JM. Inhibition of soluble epoxide hydrolase by trans-4- [4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is protective against ischemia-reperfusion injury. J Cardiovasc Pharmacol. 2010 Jan; 55(1):67-73. PMID: 19834332; PMCID: PMC2824072.
    261. Keserü B, Barbosa-Sicard E, Schermuly RT, Tanaka H, Hammock BD, Weissmann N, Fisslthaler B, Fleming I. Hypoxia-induced pulmonary hypertension: comparison of soluble epoxide hydrolase deletion vs. inhibition. Cardiovasc Res. 2010 Jan 01; 85(1):232-40. PMID: 19679679; PMCID: PMC2860707.
    262. Liu JY, Yang J, Inceoglu B, Qiu H, Ulu A, Hwang SH, Chiamvimonvat N, Hammock BD. Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model. Biochem Pharmacol. 2010 Mar 15; 79(6):880-7. PMID: 19896470; PMCID: PMC3285377.
    263. Ahn KC, Gee SJ, Tsai HJ, Bennett D, Nishioka MG, Blum A, Fishman E, Hammock BD. Immunoassay for monitoring environmental and human exposure to the polybrominated diphenyl ether BDE-47. Environ Sci Technol. 2009 Oct 15; 43(20):7784-90. PMID: 19921894; PMCID: PMC3528349.
    264. Imig JD, Hammock BD. Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases. Nat Rev Drug Discov. 2009 Oct; 8(10):794-805. PMID: 19794443; PMCID: PMC3021468.
    265. Yang J, Schmelzer K, Georgi K, Hammock BD. Quantitative profiling method for oxylipin metabolome by liquid chromatography electrospray ionization tandem mass spectrometry. Anal Chem. 2009 Oct 01; 81(19):8085-93. PMID: 19715299; PMCID: PMC3290520.
    266. Chawengsub Y, Gauthier KM, Nithipatikom K, Hammock BD, Falck JR, Narsimhaswamy D, Campbell WB. Identification of 13-hydroxy-14,15-epoxyeicosatrienoic acid as an acid-stable endothelium-derived hyperpolarizing factor in rabbit arteries. J Biol Chem. 2009 Nov 06; 284(45):31280-90. PMID: 19737933; PMCID: PMC2781526.
    267. Matveeva EG, Morisseau C, Goodrow MH, Mullin C, Hammock BD. Tryptophan fluorescence quenching by enzyme inhibitors as a tool for enzyme active site structure investigation: epoxide hydrolase. Curr Pharm Biotechnol. 2009 Sep; 10(6):589-99. PMID: 19619123; PMCID: PMC2861369.
    268. Li N, Liu JY, Timofeyev V, Qiu H, Hwang SH, Tuteja D, Lu L, Yang J, Mochida H, Low R, Hammock BD, Chiamvimonvat N. Beneficial effects of soluble epoxide hydrolase inhibitors in myocardial infarction model: Insight gained using metabolomic approaches. J Mol Cell Cardiol. 2009 Dec; 47(6):835-45. PMID: 19716829; PMCID: PMC3290524.
    269. Falck JR, Kodela R, Manne R, Atcha KR, Puli N, Dubasi N, Manthati VL, Capdevila JH, Yi XY, Goldman DH, Morisseau C, Hammock BD, Campbell WB. 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition. J Med Chem. 2009 Aug 27; 52(16):5069-75. PMID: 19653681; PMCID: PMC2888647.
    270. Barbosa-Sicard E, Frömel T, Keserü B, Brandes RP, Morisseau C, Hammock BD, Braun T, Krüger M, Fleming I. Inhibition of the soluble epoxide hydrolase by tyrosine nitration. J Biol Chem. 2009 Oct 09; 284(41):28156-63. PMID: 19704161; PMCID: PMC2788866.
    271. Liu JY, Park SH, Morisseau C, Hwang SH, Hammock BD, Weiss RH. Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo. Mol Cancer Ther. 2009 Aug; 8(8):2193-203. PMID: 19671760; PMCID: PMC2728155.
    272. Lu C, Schoenfeld R, Shan Y, Tsai HJ, Hammock B, Cortopassi G. Frataxin deficiency induces Schwann cell inflammation and death. Biochim Biophys Acta. 2009 Nov; 1792(11):1052-61. PMID: 19679182; PMCID: PMC3563672.
    273. Morisseau C, Merzlikin O, Lin A, He G, Feng W, Padilla I, Denison MS, Pessah IN, Hammock BD. Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key enzymes and receptors. Environ Health Perspect. 2009 Dec; 117(12):1867-72. PMID: 20049205; PMCID: PMC2799460.
    274. Nichkova M, Fu X, Yang Z, Zhong P, Sanborn JR, Chang D, Gee SJ, Hammock BD. Immunochemical screening of pesticides (simazine and cypermethrin) in orange oil. J Agric Food Chem. 2009 Jul 08; 57(13):5673-9. PMID: 19526986; PMCID: PMC3033343.
    275. Manhiani M, Quigley JE, Knight SF, Tasoobshirazi S, Moore T, Brands MW, Hammock BD, Imig JD. Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension. Am J Physiol Renal Physiol. 2009 Sep; 297(3):F740-8. PMID: 19553349; PMCID: PMC2739707.
    276. Luria A, Morisseau C, Tsai HJ, Yang J, Inceoglu B, De Taeye B, Watkins SM, Wiest MM, German JB, Hammock BD. Alteration in plasma testosterone levels in male mice lacking soluble epoxide hydrolase. Am J Physiol Endocrinol Metab. 2009 Aug; 297(2):E375-83. PMID: 19458064; PMCID: PMC2724109.
    277. Huang H, Tanaka H, Hammock BD, Morisseau C. Novel and highly sensitive fluorescent assay for leucine aminopeptidases. Anal Biochem. 2009 Aug 01; 391(1):11-6. PMID: 19433052; PMCID: PMC2748848.
    278. Ma Z, Dosev D, Nichkova M, Dumas RK, Gee SJ, Hammock BD, Liu K, Kennedy IM. Synthesis and characterization of multifunctional silica core-shell nanocomposites with magnetic and fluorescent functionalities. J Magn Magn Mater. 2009 May 01; 321(10):1368-1371. PMID: 20336173.
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    279. Revermann M, Barbosa-Sicard E, Dony E, Schermuly RT, Morisseau C, Geisslinger G, Fleming I, Hammock BD, Brandes RP. Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats. J Hypertens. 2009 Feb; 27(2):322-31. PMID: 19226702; PMCID: PMC2863009.
    280. Kasagami T, Kim IH, Tsai HJ, Nishi K, Hammock BD, Morisseau C. Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities. Bioorg Med Chem Lett. 2009 Mar 15; 19(6):1784-9. PMID: 19216074; PMCID: PMC2900318.
    281. Liu JY, Tsai HJ, Hwang SH, Jones PD, Morisseau C, Hammock BD. Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation. Br J Pharmacol. 2009 Jan; 156(2):284-96. PMID: 19154430; PMCID: PMC2697843.
    282. Ai D, Pang W, Li N, Xu M, Jones PD, Yang J, Zhang Y, Chiamvimonvat N, Shyy JY, Hammock BD, Zhu Y. Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy. Proc Natl Acad Sci U S A. 2009 Jan 13; 106(2):564-9. PMID: 19126686; PMCID: PMC2626743.
    283. Ma ZY, Dosev D, Nichkova M, Gee SJ, Hammock BD, Kennedy IM. Synthesis and bio-functionalization of multifunctional magnetic Fe(3)O(4)@Y(2)O(3):Eu nanocomposites. J Mater Chem. 2009 Jan 01; 19(27):4695-4700. PMID: 20357905.
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    284. Olearczyk JJ, Quigley JE, Mitchell BC, Yamamoto T, Kim IH, Newman JW, Luria A, Hammock BD, Imig JD. Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats. Clin Sci (Lond). 2009 Jan; 116(1):61-70. PMID: 18459944; PMCID: PMC2590620.
    285. Kim HJ, Ahn KC, González-Techera A, González-Sapienza GG, Gee SJ, Hammock BD. Magnetic bead-based phage anti-immunocomplex assay (PHAIA) for the detection of the urinary biomarker 3-phenoxybenzoic acid to assess human exposure to pyrethroid insecticides. Anal Biochem. 2009 Mar 01; 386(1):45-52. PMID: 19101498; PMCID: PMC2863013.
    286. Inceoglu B, Jinks SL, Ulu A, Hegedus CM, Georgi K, Schmelzer KR, Wagner K, Jones PD, Morisseau C, Hammock BD. Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways. Proc Natl Acad Sci U S A. 2008 Dec 02; 105(48):18901-6. PMID: 19028872; PMCID: PMC2596245.
    287. EnayetAllah AE, Luria A, Luo B, Tsai HJ, Sura P, Hammock BD, Grant DF. Opposite regulation of cholesterol levels by the phosphatase and hydrolase domains of soluble epoxide hydrolase. J Biol Chem. 2008 Dec 26; 283(52):36592-8. PMID: 18974052; PMCID: PMC2605982.
    288. Ulu A, Davis BB, Tsai HJ, Kim IH, Morisseau C, Inceoglu B, Fiehn O, Hammock BD, Weiss RH. Soluble epoxide hydrolase inhibitors reduce the development of atherosclerosis in apolipoprotein e-knockout mouse model. J Cardiovasc Pharmacol. 2008 Oct; 52(4):314-23. PMID: 18791465; PMCID: PMC2637359.
    289. Fife KL, Liu Y, Schmelzer KR, Tsai HJ, Kim IH, Morisseau C, Hammock BD, Kroetz DL. Inhibition of soluble epoxide hydrolase does not protect against endotoxin-mediated hepatic inflammation. J Pharmacol Exp Ther. 2008 Dec; 327(3):707-15. PMID: 18815352; PMCID: PMC2761654.
    290. Xie Y, Liu Y, Gong G, Smith DH, Yan F, Rinderspacher A, Feng Y, Zhu Z, Li X, Deng SX, Branden L, Vidovic D, Chung C, Schürer S, Morisseau C, Hammock BD, Landry DW. Discovery of potent non-urea inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett. 2009 Apr 15; 19(8):2354-9. PMID: 19303288; PMCID: PMC2738751.
    291. Harris TR, Aronov PA, Hammock BD. Soluble epoxide hydrolase homologs in Strongylocentrotus purpuratus suggest a gene duplication event and subsequent divergence. DNA Cell Biol. 2008 Sep; 27(9):467-77. PMID: 18554159; PMCID: PMC2858585.
    292. Ahn KC, Zhao B, Chen J, Cherednichenko G, Sanmarti E, Denison MS, Lasley B, Pessah IN, Kültz D, Chang DP, Gee SJ, Hammock BD. In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: receptor-based bioassay screens. Environ Health Perspect. 2008 Sep; 116(9):1203-10. PMID: 18795164; PMCID: PMC2535623.
    293. Keserü B, Barbosa-Sicard E, Popp R, Fisslthaler B, Dietrich A, Gudermann T, Hammock BD, Falck JR, Weissmann N, Busse R, Fleming I. Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response. FASEB J. 2008 Dec; 22(12):4306-15. PMID: 18725458; PMCID: PMC2614611.
    294. Hwang HM, Park EK, Young TM, Hammock BD. Occurrence of endocrine-disrupting chemicals in indoor dust. Sci Total Environ. 2008 Oct 01; 404(1):26-35. PMID: 18632138; PMCID: PMC2858057.
    295. Harris TR, Li N, Chiamvimonvat N, Hammock BD. The potential of soluble epoxide hydrolase inhibition in the treatment of cardiac hypertrophy. Congest Heart Fail. 2008 Jul-Aug; 14(4):219-24. PMID: 18780476; PMCID: PMC3748820.
    296. Biswal BK, Morisseau C, Garen G, Cherney MM, Garen C, Niu C, Hammock BD, James MN. The molecular structure of epoxide hydrolase B from Mycobacterium tuberculosis and its complex with a urea-based inhibitor. J Mol Biol. 2008 Sep 12; 381(4):897-912. PMID: 18585390; PMCID: PMC2866126.
    297. Morisseau C, Hammock BD. Gerry Brooks and epoxide hydrolases: four decades to a pharmaceutical. Pest Manag Sci. 2008 Jun; 64(6):594-609. PMID: 18383502.
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    298. Alihosseini F, Ju KS, Lango J, Hammock BD, Sun G. Antibacterial colorants: characterization of prodiginines and their applications on textile materials. Biotechnol Prog. 2008 May-Jun; 24(3):742-7. PMID: 18484779; PMCID: PMC2863012.
    299. Monti J, Fischer J, Paskas S, Heinig M, Schulz H, Gösele C, Heuser A, Fischer R, Schmidt C, Schirdewan A, Gross V, Hummel O, Maatz H, Patone G, Saar K, Vingron M, Weldon SM, Lindpaintner K, Hammock BD, Rohde K, Dietz R, Cook SA, Schunck WH, Luft FC, Hubner N. Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease. Nat Genet. 2008 May; 40(5):529-37. PMID: 18443590.
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    300. Gross GJ, Gauthier KM, Moore J, Falck JR, Hammock BD, Campbell WB, Nithipatikom K. Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart. Am J Physiol Heart Circ Physiol. 2008 Jun; 294(6):H2838-44. PMID: 18441205; PMCID: PMC2863006.
    301. Aronov PA, Hall LM, Dettmer K, Stephensen CB, Hammock BD. Metabolic profiling of major vitamin D metabolites using Diels-Alder derivatization and ultra-performance liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem. 2008 Jul; 391(5):1917-30. PMID: 18437365; PMCID: PMC3587164.
    302. Parrish AR, Chen G, Burghardt RC, Watanabe T, Morisseau C, Hammock BD. Attenuation of cisplatin nephrotoxicity by inhibition of soluble epoxide hydrolase. Cell Biol Toxicol. 2009 Jun; 25(3):217-25. PMID: 18386137; PMCID: PMC3033346.
    303. Morisseau C, Newman JW, Wheelock CE, Hill Iii T, Morin D, Buckpitt AR, Hammock BD. Development of metabolically stable inhibitors of Mammalian microsomal epoxide hydrolase. Chem Res Toxicol. 2008 Apr; 21(4):951-7. PMID: 18363382.
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    304. Kim HJ, González-Techera A, González-Sapienza GG, Ahn KC, Gee SJ, Hammock BD. Phage-borne peptidomimetics accelerate the development of polyclonal antibody-based heterologous immunoassays for the detection of pesticide metabolites. Environ Sci Technol. 2008 Mar 15; 42(6):2047-53. PMID: 18409635.
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    305. Wheelock CE, Forshed J, Goto S, Hammock BD, Newman JW. Effects of pyridine exposure upon structural lipid metabolism in Swiss Webster mice. Chem Res Toxicol. 2008 Mar; 21(3):583-90. PMID: 18251509.
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    306. Aronova S, Wedaman K, Aronov PA, Fontes K, Ramos K, Hammock BD, Powers T. Regulation of ceramide biosynthesis by TOR complex 2. Cell Metab. 2008 Feb; 7(2):148-58. PMID: 18249174; PMCID: PMC3882310.
    307. Harris TR, Aronov PA, Jones PD, Tanaka H, Arand M, Hammock BD. Identification of two epoxide hydrolases in Caenorhabditis elegans that metabolize mammalian lipid signaling molecules. Arch Biochem Biophys. 2008 Apr 15; 472(2):139-49. PMID: 18267101; PMCID: PMC2435305.
    308. Chawengsub Y, Aggarwal NT, Nithipatikom K, Gauthier KM, Anjaiah S, Hammock BD, Falck JR, Campbell WB. Identification of 15-hydroxy-11,12-epoxyeicosatrienoic acid as a vasoactive 15-lipoxygenase metabolite in rabbit aorta. Am J Physiol Heart Circ Physiol. 2008 Mar; 294(3):H1348-56. PMID: 18192225.
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    309. Park EK, Mak SK, Kültz D, Hammock BD. Determination of cytotoxicity of nephrotoxins on murine and human kidney cell lines. J Environ Sci Health B. 2008 Jan; 43(1):71-4. PMID: 18161576.
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    310. Park EK, Duarte Tagles H, Gee SJ, Hammock BD, Lee K, Schenker MB. Recruiting strategy and 24-hour biomonitoring of paraquat in agricultural workers. J Agromedicine. 2008; 13(4):207-17. PMID: 19064412; PMCID: PMC2864554.
    311. Park EK, Watanabe T, Gee SJ, Schenker MB, Hammock BD. Creatinine measurements in 24 h urine by liquid chromatography--tandem Mass Spectrometry. J Agric Food Chem. 2008 Jan 23; 56(2):333-6. PMID: 18092755.
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    312. Corenblum MJ, Wise VE, Georgi K, Hammock BD, Doris PA, Fornage M. Altered soluble epoxide hydrolase gene expression and function and vascular disease risk in the stroke-prone spontaneously hypertensive rat. Hypertension. 2008 Feb; 51(2):567-73. PMID: 18086949.
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    313. Tanaka H, Kamita SG, Wolf NM, Harris TR, Wu Z, Morisseau C, Hammock BD. Transcriptional regulation of the human soluble epoxide hydrolase gene EPHX2. Biochim Biophys Acta. 2008 Jan; 1779(1):17-27. PMID: 18078836; PMCID: PMC2699939.
    314. Park EK, Mak SK, Kültz D, Hammock BD. Evaluation of cytotoxicity attributed to thimerosal on murine and human kidney cells. J Toxicol Environ Health A. 2007 Dec; 70(24):2092-5. PMID: 18049999.
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    315. Chen J, Ahn KC, Gee NA, Ahmed MI, Duleba AJ, Zhao L, Gee SJ, Hammock BD, Lasley BL. Triclocarban enhances testosterone action: a new type of endocrine disruptor? Endocrinology. 2008 Mar; 149(3):1173-9. PMID: 18048496; PMCID: PMC2275366.
    316. Wheelock CE, Nishi K, Ying A, Jones PD, Colvin ME, Olmstead MM, Hammock BD. Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). Bioorg Med Chem. 2008 Feb 15; 16(4):2114-30. PMID: 18023188; PMCID: PMC2720161.
    317. Ahn KC, Lohstroh P, Gee SJ, Gee NA, Lasley B, Hammock BD. High-throughput automated luminescent magnetic particle-based immunoassay to monitor human exposure to pyrethroid insecticides. Anal Chem. 2007 Dec 01; 79(23):8883-90. PMID: 17983205.
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    318. Anderson PJ, Lango J, Carkeet C, Britten A, Kräutler B, Hammock BD, Roth JR. One pathway can incorporate either adenine or dimethylbenzimidazole as an alpha-axial ligand of B12 cofactors in Salmonella enterica. J Bacteriol. 2008 Feb; 190(4):1160-71. PMID: 17981976; PMCID: PMC2238215.
    319. Kim IH, Tsai HJ, Nishi K, Kasagami T, Morisseau C, Hammock BD. 1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic properties. J Med Chem. 2007 Oct 18; 50(21):5217-26. PMID: 17894481; PMCID: PMC2543935.
    320. Vogel CF, Li W, Sciullo E, Newman J, Hammock B, Reader JR, Tuscano J, Matsumura F. Pathogenesis of aryl hydrocarbon receptor-mediated development of lymphoma is associated with increased cyclooxygenase-2 expression. Am J Pathol. 2007 Nov; 171(5):1538-48. PMID: 17823287; PMCID: PMC2043515.
    321. Chiamvimonvat N, Ho CM, Tsai HJ, Hammock BD. The soluble epoxide hydrolase as a pharmaceutical target for hypertension. J Cardiovasc Pharmacol. 2007 Sep; 50(3):225-37. PMID: 17878749.
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    322. Hwang SH, Tsai HJ, Liu JY, Morisseau C, Hammock BD. Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem. 2007 Aug 09; 50(16):3825-40. PMID: 17616115; PMCID: PMC2596069.
    323. Dosev D, Nichkova M, Dumas RK, Gee SJ, Hammock BD, Liu K, Kennedy IM. Magnetic/luminescent core/shell particles synthesized by spray pyrolysis and their application in immunoassays with internal standard. Nanotechnology. 2007 Jul; 18(5):55102. PMID: 18974844.
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    324. Nichkova M, Dosev D, Gee SJ, Hammock BD, Kennedy IM. Multiplexed immunoassays for proteins using magnetic luminescent nanoparticles for internal calibration. Anal Biochem. 2007 Oct 01; 369(1):34-40. PMID: 17681270; PMCID: PMC2014785.
    325. Wheelock CE, Goto S, Hammock BD, Newman JW. Clofibrate-induced changes in the liver, heart, brain and white adipose lipid metabolome of Swiss-Webster mice. Metabolomics. 2007 Jun; 3(2):137-145. PMID: 19079556.
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    326. Ai D, Fu Y, Guo D, Tanaka H, Wang N, Tang C, Hammock BD, Shyy JY, Zhu Y. Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. Proc Natl Acad Sci U S A. 2007 May 22; 104(21):9018-23. PMID: 17495027; PMCID: PMC1885620.
    327. Kim HJ, Ahn KC, Ma SJ, Gee SJ, Hammock BD. Development of sensitive immunoassays for the detection of the glucuronide conjugate of 3-phenoxybenzyl alcohol, a putative human urinary biomarker for pyrethroid exposure. J Agric Food Chem. 2007 May 16; 55(10):3750-7. PMID: 17455946.
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    328. Zhang W, Koerner IP, Noppens R, Grafe M, Tsai HJ, Morisseau C, Luria A, Hammock BD, Falck JR, Alkayed NJ. Soluble epoxide hydrolase: a novel therapeutic target in stroke. J Cereb Blood Flow Metab. 2007 Dec; 27(12):1931-40. PMID: 17440491; PMCID: PMC2664093.
    329. Chen J, Ahn KC, Gee NA, Gee SJ, Hammock BD, Lasley BL. Antiandrogenic properties of parabens and other phenolic containing small molecules in personal care products. Toxicol Appl Pharmacol. 2007 Jun 15; 221(3):278-84. PMID: 17481686; PMCID: PMC1978490.
    330. Thompson DA, Hammock BD. Dihydroxyoctadecamonoenoate esters inhibit the neutrophil respiratory burst. J Biosci. 2007 Mar; 32(2):279-91. PMID: 17435320; PMCID: PMC1904342.
    331. Akatsuka T, Kobayashi N, Ishikawa T, Saito T, Shindo M, Yamauchi M, Kurokohchi K, Miyazawa H, Duan H, Matsunaga T, Komoda T, Morisseau C, Hammock BD. Autoantibody response to microsomal epoxide hydrolase in hepatitis C and A. J Autoimmun. 2007 Feb; 28(1):7-18. PMID: 17296285; PMCID: PMC1892246.
    332. Morisseau C, Hammock BD. Measurement of soluble epoxide hydrolase (sEH) activity. Curr Protoc Toxicol. 2007; Chapter 4:Unit 4.23. PMID: 23045145.
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    333. Dettmer K, Aronov PA, Hammock BD. Mass spectrometry-based metabolomics. Mass Spectrom Rev. 2007 Jan-Feb; 26(1):51-78. PMID: 16921475; PMCID: PMC1904337.
    334. Huang H, Nishi K, Tsai HJ, Hammock BD. Development of highly sensitive fluorescent assays for fatty acid amide hydrolase. Anal Biochem. 2007 Apr 01; 363(1):12-21. PMID: 17291440; PMCID: PMC1995106.
    335. Luria A, Weldon SM, Kabcenell AK, Ingraham RH, Matera D, Jiang H, Gill R, Morisseau C, Newman JW, Hammock BD. Compensatory mechanism for homeostatic blood pressure regulation in Ephx2 gene-disrupted mice. J Biol Chem. 2007 Feb 02; 282(5):2891-8. PMID: 17135253; PMCID: PMC2040337.
    336. Xu D, Li N, He Y, Timofeyev V, Lu L, Tsai HJ, Kim IH, Tuteja D, Mateo RK, Singapuri A, Davis BB, Low R, Hammock BD, Chiamvimonvat N. Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors. Proc Natl Acad Sci U S A. 2006 Dec 05; 103(49):18733-8. PMID: 17130447; PMCID: PMC1693731.
    337. Morisseau C, Newman JW, Tsai HJ, Baecker PA, Hammock BD. Peptidyl-urea based inhibitors of soluble epoxide hydrolases. Bioorg Med Chem Lett. 2006 Oct 15; 16(20):5439-44. PMID: 16908134; PMCID: PMC1892215.
    338. Kim IH, Nishi K, Tsai HJ, Bradford T, Koda Y, Watanabe T, Morisseau C, Blanchfield J, Toth I, Hammock BD. Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase. Bioorg Med Chem. 2007 Jan 01; 15(1):312-23. PMID: 17046265; PMCID: PMC2040326.
    339. Hwang SH, Morisseau C, Do Z, Hammock BD. Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett. 2006 Nov 15; 16(22):5773-7. PMID: 16949285; PMCID: PMC1904340.
    340. Schmelzer KR, Wheelock AM, Dettmer K, Morin D, Hammock BD. The role of inflammatory mediators in the synergistic toxicity of ozone and 1-nitronaphthalene in rat airways. Environ Health Perspect. 2006 Sep; 114(9):1354-60. PMID: 16966088; PMCID: PMC1570074.
    341. Schmelzer KR, Inceoglu B, Kubala L, Kim IH, Jinks SL, Eiserich JP, Hammock BD. Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors. Proc Natl Acad Sci U S A. 2006 Sep 12; 103(37):13646-51. PMID: 16950874; PMCID: PMC1564210.
    342. Inceoglu B, Jinks SL, Schmelzer KR, Waite T, Kim IH, Hammock BD. Inhibition of soluble epoxide hydrolase reduces LPS-induced thermal hyperalgesia and mechanical allodynia in a rat model of inflammatory pain. Life Sci. 2006 Nov 10; 79(24):2311-9. PMID: 16962614; PMCID: PMC1904345.
    343. Jones PD, Tsai HJ, Do ZN, Morisseau C, Hammock BD. Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett. 2006 Oct 01; 16(19):5212-6. PMID: 16870439; PMCID: PMC1904344.
    344. Seubert JM, Sinal CJ, Graves J, DeGraff LM, Bradbury JA, Lee CR, Goralski K, Carey MA, Luria A, Newman JW, Hammock BD, Falck JR, Roberts H, Rockman HA, Murphy E, Zeldin DC. Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function. Circ Res. 2006 Aug 18; 99(4):442-50. PMID: 16857962.
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    345. Inceoglu B, Schmelzer KR, Morisseau C, Jinks SL, Hammock BD. Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs). Prostaglandins Other Lipid Mediat. 2007 Jan; 82(1-4):42-9. PMID: 17164131; PMCID: PMC1904338.
    346. Li HY, Jin Y, Morisseau C, Hammock BD, Long YQ. The 5-substituted piperazine as a novel secondary pharmacophore greatly improving the physical properties of urea-based inhibitors of soluble epoxide hydrolase. Bioorg Med Chem. 2006 Oct 01; 14(19):6586-92. PMID: 16784862; PMCID: PMC2040075.
    347. Olearczyk JJ, Field MB, Kim IH, Morisseau C, Hammock BD, Imig JD. Substituted adamantyl-urea inhibitors of the soluble epoxide hydrolase dilate mesenteric resistance vessels. J Pharmacol Exp Ther. 2006 Sep; 318(3):1307-14. PMID: 16772540.
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    348. Koivunen ME, Dettmer K, Vermeulen R, Bakke B, Gee SJ, Hammock BD. Improved methods for urinary atrazine mercapturate analysis--assessment of an enzyme-linked immunosorbent assay (ELISA) and a novel liquid chromatography-mass spectrometry (LC-MS) method utilizing online solid phase extraction (SPE). Anal Chim Acta. 2006 Jul 21; 572(2):180-9. PMID: 17723476.
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    349. Wolf NM, Morisseau C, Jones PD, Hock B, Hammock BD. Development of a high-throughput screen for soluble epoxide hydrolase inhibition. Anal Biochem. 2006 Aug 01; 355(1):71-80. PMID: 16729954; PMCID: PMC1964503.
    350. Wogulis M, Wheelock CE, Kamita SG, Hinton AC, Whetstone PA, Hammock BD, Wilson DK. Structural studies of a potent insect maturation inhibitor bound to the juvenile hormone esterase of Manduca sexta. Biochemistry. 2006 Apr 04; 45(13):4045-57. PMID: 16566578; PMCID: PMC4275126.
    351. Lee CR, North KE, Bray MS, Fornage M, Seubert JM, Newman JW, Hammock BD, Couper DJ, Heiss G, Zeldin DC. Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study. Hum Mol Genet. 2006 May 15; 15(10):1640-9. PMID: 16595607.
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    352. Carkeet C, Dueker SR, Lango J, Buchholz BA, Miller JW, Green R, Hammock BD, Roth JR, Anderson PJ. Human vitamin B12 absorption measurement by accelerator mass spectrometry using specifically labeled (14)C-cobalamin. Proc Natl Acad Sci U S A. 2006 Apr 11; 103(15):5694-9. PMID: 16585531.
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    353. Wheelock CE, Miller JL, Miller MJ, Phillips BM, Huntley SA, Gee SJ, Tjeerdema RS, Hammock BD. Use of carboxylesterase activity to remove pyrethroid-associated toxicity to Ceriodaphnia dubia and Hyalella azteca in toxicity identification evaluations. Environ Toxicol Chem. 2006 Apr; 25(4):973-84. PMID: 16629136; PMCID: PMC1456014.
    354. Watanabe T, Schulz D, Morisseau C, Hammock BD. High-throughput pharmacokinetic method: cassette dosing in mice associated with minuscule serial bleedings and LC/MS/MS analysis. Anal Chim Acta. 2006 Feb 10; 559(1):37-44. PMID: 16636700.
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    355. Huang H, Nishi K, Gee SJ, Hammock BD. Evaluation of chiral alpha-cyanoesters as general fluorescent substrates for screening enantioselective esterases. J Agric Food Chem. 2006 Feb 08; 54(3):694-9. PMID: 16448170; PMCID: PMC1444886.
    356. Nichkova M, Dosev D, Perron R, Gee SJ, Hammock BD, Kennedy IM. Eu3+-doped Gd2O3 nanoparticles as reporters for optical detection and visualization of antibodies patterned by microcontact printing. Anal Bioanal Chem. 2006 Feb; 384(3):631-7. PMID: 16416096.
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    357. Ahn KC, Ma SJ, Tsai HJ, Gee SJ, Hammock BD. An immunoassay for a urinary metabolite as a biomarker of human exposure to the pyrethroid insecticide permethrin. Anal Bioanal Chem. 2006 Feb; 384(3):713-22. PMID: 16416099.
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    358. Inceoglu AB, Kamita SG, Hammock BD. Genetically modified baculoviruses: a historical overview and future outlook. Adv Virus Res. 2006; 68:323-60. PMID: 16997016.
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    359. Nishi K, Huang H, Kamita SG, Kim IH, Morisseau C, Hammock BD. Characterization of pyrethroid hydrolysis by the human liver carboxylesterases hCE-1 and hCE-2. Arch Biochem Biophys. 2006 Jan 01; 445(1):115-23. PMID: 16359636; PMCID: PMC1444892.
    360. Inceoglu B, Lango J, Rabinovich A, Whetstone P, Hammock BD. The neutralizing effect of a polyclonal antibody raised against the N-terminal eighteen-aminoacid residues of birtoxin towards the whole venom of Parabuthus transvaalicus. Toxicon. 2006 Feb; 47(2):144-9. PMID: 16356521.
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    361. Gomez GA, Morisseau C, Hammock BD, Christianson DW. Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids. Protein Sci. 2006 Jan; 15(1):58-64. PMID: 16322563; PMCID: PMC1762130.
    362. Liu Y, Zhang Y, Schmelzer K, Lee TS, Fang X, Zhu Y, Spector AA, Gill S, Morisseau C, Hammock BD, Shyy JY. The antiinflammatory effect of laminar flow: the role of PPARgamma, epoxyeicosatrienoic acids, and soluble epoxide hydrolase. Proc Natl Acad Sci U S A. 2005 Nov 15; 102(46):16747-52. PMID: 16267130; PMCID: PMC1276614.
    363. Dosev D, Nichkova M, Liu M, Guo B, Liu GY, Hammock BD, Kennedy IM. Application of luminescent Eu:Gd2O3 nanoparticles to the visualization of protein micropatterns. J Biomed Opt. 2005 Nov-Dec; 10(6):064006. PMID: 16409071.
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    364. Nichkova M, Dosev D, Gee SJ, Hammock BD, Kennedy IM. Microarray immunoassay for phenoxybenzoic acid using polymer encapsulated Eu:Gd2O3 nanoparticles as fluorescent labels. Anal Chem. 2005 Nov 01; 77(21):6864-73. PMID: 16255584.
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    365. Larsen BT, Miura H, Hatoum OA, Campbell WB, Hammock BD, Zeldin DC, Falck JR, Gutterman DD. Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BK(Ca) channels: implications for soluble epoxide hydrolase inhibition. Am J Physiol Heart Circ Physiol. 2006 Feb; 290(2):H491-9. PMID: 16258029; PMCID: PMC1456013.
    366. Davis BB, Morisseau C, Newman JW, Pedersen TL, Hammock BD, Weiss RH. Attenuation of vascular smooth muscle cell proliferation by 1-cyclohexyl-3-dodecyl urea is independent of soluble epoxide hydrolase inhibition. J Pharmacol Exp Ther. 2006 Feb; 316(2):815-21. PMID: 16221742.
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    367. Kang KD, Jones PD, Huang H, Zhang R, Mostovich LA, Wheelock CE, Watanabe T, Gulyaeva LF, Hammock BD. Evaluation of alpha-cyano ethers as fluorescent substrates for assay of cytochrome P450 enzyme activity. Anal Biochem. 2005 Sep 15; 344(2):183-92. PMID: 16083846; PMCID: PMC1450254.
    368. Tran KL, Aronov PA, Tanaka H, Newman JW, Hammock BD, Morisseau C. Lipid sulfates and sulfonates are allosteric competitive inhibitors of the N-terminal phosphatase activity of the mammalian soluble epoxide hydrolase. Biochemistry. 2005 Sep 13; 44(36):12179-87. PMID: 16142916; PMCID: PMC1473036.
    369. Huang H, Fleming CD, Nishi K, Redinbo MR, Hammock BD. Stereoselective hydrolysis of pyrethroid-like fluorescent substrates by human and other mammalian liver carboxylesterases. Chem Res Toxicol. 2005 Sep; 18(9):1371-7. PMID: 16167828; PMCID: PMC1444893.
    370. Wheelock CE, Eder KJ, Werner I, Huang H, Jones PD, Brammell BF, Elskus AA, Hammock BD. Individual variability in esterase activity and CYP1A levels in Chinook salmon (Oncorhynchus tshawytscha) exposed to esfenvalerate and chlorpyrifos. Aquat Toxicol. 2005 Aug 30; 74(2):172-92. PMID: 16011852; PMCID: PMC1444896.
    371. Wheelock CE, Miller JL, Miller MJ, Phillips BM, Gee SJ, Tjeerdema RS, Hammock BD. Influence of container adsorption upon observed pyrethroid toxicity to Ceriodaphnia dubia and Hyalella azteca. Aquat Toxicol. 2005 Aug 15; 74(1):47-52. PMID: 15951033; PMCID: PMC1450256.
    372. Jones PD, Wolf NM, Morisseau C, Whetstone P, Hock B, Hammock BD. Fluorescent substrates for soluble epoxide hydrolase and application to inhibition studies. Anal Biochem. 2005 Aug 01; 343(1):66-75. PMID: 15963942; PMCID: PMC1447601.
    373. Schmelzer KR, Kubala L, Newman JW, Kim IH, Eiserich JP, Hammock BD. Soluble epoxide hydrolase is a therapeutic target for acute inflammation. Proc Natl Acad Sci U S A. 2005 Jul 12; 102(28):9772-7. PMID: 15994227; PMCID: PMC1168955.
    374. Kim IH, Heirtzler FR, Morisseau C, Nishi K, Tsai HJ, Hammock BD. Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem. 2005 May 19; 48(10):3621-9. PMID: 15887969; PMCID: PMC1450255.
    375. Aronov PA, Dettmer K, Christiansen JA, Cornel AJ, Hammock BD. Development of a HPLC/tandem-MS method for the analysis of the larvicides methoprene, hydroprene, and kinoprene at trace levels using Diels-Alder derivatization. J Agric Food Chem. 2005 May 04; 53(9):3306-12. PMID: 15853364; PMCID: PMC1479544.
    376. Kamita SG, Do ZN, Samra AI, Hagler JR, Hammock BD. Characterization of cell lines developed from the glassy-winged sharpshooter, Homalodisca coagulata (Hemiptera: Cicadellidae). In Vitro Cell Dev Biol Anim. 2005 May-Jun; 41(5-6):149-53. PMID: 16153147.
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    377. Inceoglu B, Lango J, Pessah IN, Hammock BD. Three structurally related, highly potent, peptides from the venom of Parabuthus transvaalicus possess divergent biological activity. Toxicon. 2005 May; 45(6):727-33. PMID: 15804521.
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    378. Fang X, Hu S, Watanabe T, Weintraub NL, Snyder GD, Yao J, Liu Y, Shyy JY, Hammock BD, Spector AA. Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors. J Pharmacol Exp Ther. 2005 Jul; 314(1):260-70. PMID: 15798002.
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    379. Huang H, Stok JE, Stoutamire DW, Gee SJ, Hammock BD. Development of optically pure pyrethroid-like fluorescent substrates for carboxylesterases. Chem Res Toxicol. 2005 Mar; 18(3):516-27. PMID: 15777092.
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    380. Jung O, Brandes RP, Kim IH, Schweda F, Schmidt R, Hammock BD, Busse R, Fleming I. Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension. Hypertension. 2005 Apr; 45(4):759-65. PMID: 15699457.
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    381. Kamita SG, Nagasaka K, Chua JW, Shimada T, Mita K, Kobayashi M, Maeda S, Hammock BD. A baculovirus-encoded protein tyrosine phosphatase gene induces enhanced locomotory activity in a lepidopteran host. Proc Natl Acad Sci U S A. 2005 Feb 15; 102(7):2584-9. PMID: 15699333; PMCID: PMC548987.
    382. Smith KR, Pinkerton KE, Watanabe T, Pedersen TL, Ma SJ, Hammock BD. Attenuation of tobacco smoke-induced lung inflammation by treatment with a soluble epoxide hydrolase inhibitor. Proc Natl Acad Sci U S A. 2005 Feb 08; 102(6):2186-91. PMID: 15684051; PMCID: PMC548576.
    383. Newman JW, Morisseau C, Hammock BD. Epoxide hydrolases: their roles and interactions with lipid metabolism. Prog Lipid Res. 2005 Jan; 44(1):1-51. PMID: 15748653.
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    384. Sellers KW, Sun C, Diez-Freire C, Waki H, Morisseau C, Falck JR, Hammock BD, Paton JF, Raizada MK. Novel mechanism of brain soluble epoxide hydrolase-mediated blood pressure regulation in the spontaneously hypertensive rat. FASEB J. 2005 Apr; 19(6):626-8. PMID: 15659536.
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    385. Morisseau C, Hammock BD. Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles. Annu Rev Pharmacol Toxicol. 2005; 45:311-33. PMID: 15822179.
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    386. Wheelock CE, Miller JL, Miller MJ, Gee SJ, Shan G, Hammock BD. Development of toxicity identification evaluation procedures for pyrethroid detection using esterase activity. Environ Toxicol Chem. 2004 Nov; 23(11):2699-708. PMID: 15559286.
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    387. Stok JE, Goloshchapov A, Song C, Wheelock CE, Derbel MB, Morisseau C, Hammock BD. Investigation of the role of a second conserved serine in carboxylesterases via site-directed mutagenesis. Arch Biochem Biophys. 2004 Oct 15; 430(2):247-55. PMID: 15369824.
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    388. Park EK, Kim JH, Gee SJ, Watanabe T, Ahn KC, Hammock BD. Determination of pyrethroid residues in agricultural products by an enzyme-linked immunosorbent assay. J Agric Food Chem. 2004 Sep 08; 52(18):5572-6. PMID: 15373394.
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    389. Nichkova M, Park EK, Koivunen ME, Kamita SG, Gee SJ, Chuang J, Emon JM, Hammock BD. Immunochemical determination of dioxins in sediment and serum samples. Talanta. 2004 Aug 08; 63(5):1213-23. PMID: 18969550.
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    390. Fang X, Weintraub NL, McCaw RB, Hu S, Harmon SD, Rice JB, Hammock BD, Spector AA. Effect of soluble epoxide hydrolase inhibition on epoxyeicosatrienoic acid metabolism in human blood vessels. Am J Physiol Heart Circ Physiol. 2004 Dec; 287(6):H2412-20. PMID: 15284062.
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    391. Ahn KC, Watanabe T, Gee SJ, Hammock BD. Hapten and antibody production for a sensitive immunoassay determining a human urinary metabolite of the pyrethroid insecticide permethrin. J Agric Food Chem. 2004 Jul 28; 52(15):4583-94. PMID: 15264887.
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    392. Zhao X, Yamamoto T, Newman JW, Kim IH, Watanabe T, Hammock BD, Stewart J, Pollock JS, Pollock DM, Imig JD. Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage. J Am Soc Nephrol. 2004 May; 15(5):1244-53. PMID: 15100364.
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    393. Stok JE, Huang H, Jones PD, Wheelock CE, Morisseau C, Hammock BD. Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes. J Biol Chem. 2004 Jul 09; 279(28):29863-9. PMID: 15123619.
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    394. Kim IH, Morisseau C, Watanabe T, Hammock BD. Design, synthesis, and biological activity of 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility. J Med Chem. 2004 Apr 08; 47(8):2110-22. PMID: 15056008.
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    395. McAbee RD, Kang KD, Stanich MA, Christiansen JA, Wheelock CE, Inman AD, Hammock BD, Cornel AJ. Pyrethroid tolerance in Culex pipiens pipiens var molestus from Marin County, California. Pest Manag Sci. 2004 Apr; 60(4):359-68. PMID: 15119598.
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    396. Lee HJ, Shan G, Ahn KC, Park EK, Watanabe T, Gee SJ, Hammock BD. Development of an enzyme-linked immunosorbent assay for the pyrethroid cypermethrin. J Agric Food Chem. 2004 Mar 10; 52(5):1039-43. PMID: 14995094.
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    397. Koivunen ME, Morisseau C, Horwath WR, Hammock BD. Isolation of a strain of Agrobacterium tumefaciens (Rhizobium radiobacter) utilizing methylene urea (ureaformaldehyde) as nitrogen source. Can J Microbiol. 2004 Mar; 50(3):167-74. PMID: 15105883.
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    398. Shan G, Huang H, Stoutamire DW, Gee SJ, Leng G, Hammock BD. A sensitive class specific immunoassay for the detection of pyrethroid metabolites in human urine. Chem Res Toxicol. 2004 Feb; 17(2):218-25. PMID: 14967009.
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    399. DuTeaux SB, Newman JW, Morisseau C, Fairbairn EA, Jelks K, Hammock BD, Miller MG. Epoxide hydrolases in the rat epididymis: possible roles in xenobiotic and endogenous fatty acid metabolism. Toxicol Sci. 2004 Apr; 78(2):187-95. PMID: 14737000.
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    400. Yu Z, Davis BB, Morisseau C, Hammock BD, Olson JL, Kroetz DL, Weiss RH. Vascular localization of soluble epoxide hydrolase in the human kidney. Am J Physiol Renal Physiol. 2004 Apr; 286(4):F720-6. PMID: 14665429.
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    401. Kamita SG, Maeda S, Hammock BD. High-frequency homologous recombination between baculoviruses involves DNA replication. J Virol. 2003 Dec; 77(24):13053-61. PMID: 14645562; PMCID: PMC296086.
    402. Taniai K, Inceoglu AB, Yukuhiro K, Hammock BD. Characterization and cDNA cloning of a clofibrate-inducible microsomal epoxide hydrolase in Drosophila melanogaster. Eur J Biochem. 2003 Dec; 270(23):4696-705. PMID: 14622257.
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    403. Kamita SG, Hinton AC, Wheelock CE, Wogulis MD, Wilson DK, Wolf NM, Stok JE, Hock B, Hammock BD. Juvenile hormone (JH) esterase: why are you so JH specific? Insect Biochem Mol Biol. 2003 Dec; 33(12):1261-73. PMID: 14599498.
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    404. Feng J, Shan G, Hammock BD, Kennedy IM. Fluorescence quenching competitive immunoassay in micro droplets. Biosens Bioelectron. 2003 Aug 01; 18(8):1055-63. PMID: 12782469.
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    405. Przybyla-Zawislak BD, Srivastava PK, Vazquez-Matias J, Mohrenweiser HW, Maxwell JE, Hammock BD, Bradbury JA, Enayetallah AE, Zeldin DC, Grant DF. Polymorphisms in human soluble epoxide hydrolase. Mol Pharmacol. 2003 Aug; 64(2):482-90. PMID: 12869654.
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    406. Watanabe T, Morisseau C, Newman JW, Hammock BD. In vitro metabolism of the mammalian soluble epoxide hydrolase inhibitor, 1-cyclohexyl-3-dodecyl-urea. Drug Metab Dispos. 2003 Jul; 31(7):846-53. PMID: 12814960.
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    407. Wheelock CE, Wheelock AM, Zhang R, Stok JE, Morisseau C, Le Valley SE, Green CE, Hammock BD. Evaluation of alpha-cyanoesters as fluorescent substrates for examining interindividual variation in general and pyrethroid-selective esterases in human liver microsomes. Anal Biochem. 2003 Apr 15; 315(2):208-22. PMID: 12689831.
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    408. McElroy NR, Jurs PC, Morisseau C, Hammock BD. QSAR and classification of murine and human soluble epoxide hydrolase inhibition by urea-like compounds. J Med Chem. 2003 Mar 13; 46(6):1066-80. PMID: 12620084.
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    409. Regev A, Rivkin H, Inceoglu B, Gershburg E, Hammock BD, Gurevitz M, Chejanovsky N. Further enhancement of baculovirus insecticidal efficacy with scorpion toxins that interact cooperatively. FEBS Lett. 2003 Feb 27; 537(1-3):106-10. PMID: 12606040.
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    410. Newman JW, Morisseau C, Harris TR, Hammock BD. The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1558-63. PMID: 12574510; PMCID: PMC149871.
    411. Inceoglu B, Lango J, Jing J, Chen L, Doymaz F, Pessah IN, Hammock BD. One scorpion, two venoms: prevenom of Parabuthus transvaalicus acts as an alternative type of venom with distinct mechanism of action. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):922-7. PMID: 12552107; PMCID: PMC298702.
    412. Wheelock CE, Colvin ME, Uemura I, Olmstead MM, Sanborn JR, Nakagawa Y, Jones AD, Hammock BD. Use of ab initio calculations to predict the biological potency of carboxylesterase inhibitors. J Med Chem. 2002 Dec 05; 45(25):5576-93. PMID: 12459025.
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    413. Severson TF, Goodrow MH, Morisseau C, Dowdy DL, Hammock BD. Urea and amide-based inhibitors of the juvenile hormone epoxide hydrolase of the tobacco hornworm (Manduca sexta: Sphingidae). Insect Biochem Mol Biol. 2002 Dec; 32(12):1741-56. PMID: 12429126.
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    414. Inceoglu AB, Hayashida Y, Lango J, Ishida AT, Hammock BD. A single charged surface residue modifies the activity of ikitoxin, a beta-type Na+ channel toxin from Parabuthus transvaalicus. Eur J Biochem. 2002 Nov; 269(22):5369-76. PMID: 12423335.
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    415. Fornage M, Hinojos CA, Nurowska BW, Boerwinkle E, Hammock BD, Morisseau CH, Doris PA. Polymorphism in soluble epoxide hydrolase and blood pressure in spontaneously hypertensive rats. Hypertension. 2002 Oct; 40(4):485-90. PMID: 12364351.
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    416. Lee HJ, Shan G, Watanabe T, Stoutamire DW, Gee SJ, Hammock BD. Enzyme-linked immunosorbent assay for the pyrethroid deltamethrin. J Agric Food Chem. 2002 Sep 25; 50(20):5526-32. PMID: 12236674.
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    417. Newman JW, Watanabe T, Hammock BD. The simultaneous quantification of cytochrome P450 dependent linoleate and arachidonate metabolites in urine by HPLC-MS/MS. J Lipid Res. 2002 Sep; 43(9):1563-78. PMID: 12235189.
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    418. Fang X, Weintraub NL, Oltman CL, Stoll LL, Kaduce TL, Harmon S, Dellsperger KC, Morisseau C, Hammock BD, Spector AA. Human coronary endothelial cells convert 14,15-EET to a biologically active chain-shortened epoxide. Am J Physiol Heart Circ Physiol. 2002 Dec; 283(6):H2306-14. PMID: 12388281.
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    419. Morisseau C, Goodrow MH, Newman JW, Wheelock CE, Dowdy DL, Hammock BD. Structural refinement of inhibitors of urea-based soluble epoxide hydrolases. Biochem Pharmacol. 2002 May 01; 63(9):1599-608. PMID: 12007563.
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    420. Wang GY, Michailides TJ, Hammock BD, Lee YM, Bostock RM. Molecular cloning, characterization, and expression of a redox-responsive cutinase from Monilinia fructicola (Wint.) Honey. Fungal Genet Biol. 2002 Apr; 35(3):261-76. PMID: 11929215.
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    421. Davis BB, Thompson DA, Howard LL, Morisseau C, Hammock BD, Weiss RH. Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2222-7. PMID: 11842228; PMCID: PMC122346.
    422. Imig JD, Zhao X, Capdevila JH, Morisseau C, Hammock BD. Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension. Hypertension. 2002 Feb; 39(2 Pt 2):690-4. PMID: 11882632.
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    423. Nagy SR, Sanborn JR, Hammock BD, Denison MS. Development of a green fluorescent protein-based cell bioassay for the rapid and inexpensive detection and characterization of ah receptor agonists. Toxicol Sci. 2002 Feb; 65(2):200-10. PMID: 11812924.
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    424. Szurdoki F, Székács A, Le HM, Hammock BD. Synthesis of haptens and protein conjugates for the development of immunoassays for the insect growth regulator fenoxycarb. J Agric Food Chem. 2002 Jan 02; 50(1):29-40. PMID: 11754538.
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