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Robert J Brosnan

Title(s)Professor, School of Veterinary Medicine
SchoolUniversity of California, Davis
Address1306 Tupper Hall
CA 95616
Phone530-754-6476
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    Collapse Research 
    Collapse Research Activities and Funding
    Does Anesthetic Solubility Determine Receptor Specificity?
    NIH/NIGMS R01GM092821Sep 30, 2010 - Aug 31, 2014
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Phenylpiperidine opioid effects on isoflurane minimum alveolar concentration in cats. J Vet Pharmacol Ther. 2020 Jun 17. Brosnan RJ, Pypendop BH, Stanley SD. PMID: 32557697.
      View in: PubMed   Mentions:    Fields:    
    2. In vitro and in vivo GABAA Receptor Interaction of the Propanidid Metabolite 4-(2-[Diethylamino]-2-Oxoethoxy)-3-Methoxy-Benzeneacetic Acid. Pharmacology. 2019; 103(1-2):10-16. Cenani A, Brosnan RJ, Knych HK. PMID: 30332672.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Anesthetic-sensitive ion channel modulation is associated with a molar water solubility cut-off. BMC Pharmacol Toxicol. 2018 Sep 14; 19(1):57. Brosnan RJ, Pham TL. PMID: 30217234.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    4. Pharmacokinetics and antinociceptive effects of the soluble epoxide hydrolase inhibitor t-TUCB in horses with experimentally induced radiocarpal synovitis. J Vet Pharmacol Ther. 2018 Apr; 41(2):230-238. Guedes AGP, Aristizabal F, Sole A, Adedeji A, Brosnan R, Knych H, Yang J, Hwang SH, Morisseau C, Hammock BD. PMID: 29067696.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    5. Pharmacokinetics and pharmacodynamics of intravenous romifidine and propranolol administered alone or in combination for equine sedation. Vet Anaesth Analg. 2017 Jan; 44(1):86-97. Cenani A, Brosnan RJ, Madigan S, Knych HK, Madigan JE. PMID: 27426730.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    6. Investigation of perioperative and anesthetic variables affecting short-term survival of horses with small intestinal strangulating lesions. Vet Surg. 2017 Apr; 46(3):345-353. Espinosa P, Le Jeune SS, Cenani A, Kass PH, Brosnan RJ. PMID: 28152199.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    7. Anesthetic synergy between two n-alkanes. Vet Anaesth Analg. 2017 May; 44(3):577-588. Brosnan RJ, Fukushima FB, Pham TL. PMID: 28583773.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    8. GABAA Receptor Modulation by Phenyl Ring Compounds Is Associated with a Water Solubility Cut-Off Value. Pharmacology. 2016; 98(1-2):13-9. Brosnan RJ, Pham TL. PMID: 26986632.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    9. Qualitative and Quantitative Characteristics of the Electroencephalogram in Normal Horses during Administration of Inhaled Anesthesia. J Vet Intern Med. 2016 Jan-Feb; 30(1):289-303. Williams DC, Brosnan RJ, Fletcher DJ, Aleman M, Holliday TA, Tharp B, Kass PH, LeCouteur RA, Steffey EP. PMID: 26714626.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCTClinical Trials
    10. Effects of estradiol on uterine perfusion in anesthetized cyclic mares affected with uterine vascular elastosis. Anim Reprod Sci. 2016 Jan; 164:57-63. Esteller-Vico A, Liu IK, Vaughan B, Steffey EP, Brosnan RJ. PMID: 26642749.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    11. Electroencephalogram of Healthy Horses During Inhaled Anesthesia. J Vet Intern Med. 2016 Jan-Feb; 30(1):304-8. Williams DC, Aleman MR, Brosnan RJ, Fletcher DJ, Holliday TA, Tharp B, Kass PH, Steffey EP, LeCouteur RA. PMID: 26376458.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    12. Equivalence between invasive and oscillometric blood pressures at different anatomic locations in healthy normotensive anaesthetised horses. Equine Vet J. 2016 May; 48(3):357-61. Tearney CC, Guedes AG, Brosnan RJ. PMID: 25790220.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    13. Inhalation Anesthetics. . 2015 Apr 29; 297-331. Eugene P. Steffey, Khursheed R. Mama, Robert J. Brosnan. .
      View in: Publisher Site   Mentions:
    14. Desflurane and sevoflurane elimination kinetics and recovery quality in horses. Am J Vet Res. 2015 Mar; 76(3):201-7. Valente AC, Brosnan RJ, Guedes AG. PMID: 25710755.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    15. Effects of vascular elastosis on uterine blood flow and perfusion in anesthetized mares. Theriogenology. 2015 Apr 01; 83(6):988-94. Esteller-Vico A, Liu IK, Vaughan B, Steffey EP, Brosnan RJ. PMID: 25543154.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    16. Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation. BMC Pharmacol Toxicol. 2014 Nov 19; 15:62. Brosnan RJ, Pham TL. PMID: 25410726.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    17. Rabbit model of chest wall rigidity induced by fentanyl and the effects of apomorphine. Respir Physiol Neurobiol. 2014 Oct 01; 202:50-2. Soares JH, Brosnan RJ, Smith A, Mayhew PD. PMID: 25093961.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    18. Hilar closure using staplers or Hem-o-lok clips in a rabbit model. J Surg Res. 2014 Dec; 192(2):616-20. Smith AL, Mayhew PD, Soares JH, Kass PH, Brosnan RJ. PMID: 25167784.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    19. Cardiopulmonary effects of butorphanol in sevoflurane-anesthetized guineafowl (Numida meleagris). Veterinary Anaesthesia and Analgesia. 2014 May 1; 41(3):284-289. André Escobar, Carlos AA Valadão, Robert J Brosnan, Fabíola N Flôres, Maristela CS Lopes, Fábio N Gava. .
      View in: Publisher Site   Mentions:
    20. Effects of acetylcholinesterase inhibition on quality of recovery from isoflurane-induced anesthesia in horses. Am J Vet Res. 2014 Mar; 75(3):223-30. Wiese AJ, Brosnan RJ, Barter LS. PMID: 24564307.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    21. Pharmacokinetics and physiological effects of repeated oral administrations of tramadol in horses. J Vet Pharmacol Ther. 2014 Jun; 37(3):269-78. Guedes AG, Knych HK, Soares JH, Brosnan RJ. PMID: 24180699.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    22. Sensory nerve conduction and somatosensory evoked potentials of the trigeminal nerve in horses with idiopathic headshaking. J Vet Intern Med. 2013 Nov-Dec; 27(6):1571-80. Aleman M, Williams DC, Brosnan RJ, Nieto JE, Pickles KJ, Berger J, Lecouteur RA, Holliday TA, Madigan JE. PMID: 24107198.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    23. Effects of ketamine, propofol, or thiopental administration on intraocular pressure and qualities of induction of and recovery from anesthesia in horses. Am J Vet Res. 2013 Aug; 74(8):1070-7. Ferreira TH, Brosnan RJ, Shilo-Benjamini Y, Moore SB, Hollingsworth SR. PMID: 23879844.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    24. Pharmacokinetics of fentanyl, alfentanil, and sufentanil in isoflurane-anesthetized cats. J Vet Pharmacol Ther. 2014 Feb; 37(1):13-7. Pypendop BH, Brosnan RJ, Majewski-Tiedeken CR, Stanley SD, Ilkiw JE. PMID: 23895731.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCTClinical Trials
    25. Effects of postanesthetic sedation with romifidine or xylazine on quality of recovery from isoflurane anesthesia in horses. J Am Vet Med Assoc. 2013 Feb 15; 242(4):533-9. Woodhouse KJ, Brosnan RJ, Nguyen KQ, Moniz GW, Galuppo LD. PMID: 23363287.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    26. Inhaled anesthetics in horses. Vet Clin North Am Equine Pract. 2013 Apr; 29(1):69-87. Brosnan RJ. PMID: 23498046.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    27. Naltrexone does not affect isoflurane minimum alveolar concentration in cats. Vet Anaesth Analg. 2013 Mar; 40(2):225-8. Brosnan RJ, Pypendop BH, Majewski-Tiedeken CR, Shilo-Benjamini Y, Ilkiw JE. PMID: 23279646.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCTClinical Trials
    28. Use of physiologic and arterial blood gas variables to predict short-term survival in horses with large colon volvulus. Vet Surg. 2013 Jan; 42(1):107-13. Kelleher ME, Brosnan RJ, Kass PH, le Jeune SS. PMID: 23216048.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    29. Evaluation of squeeze-induced somnolence in neonatal foals. Am J Vet Res. 2012 Dec; 73(12):1881-9. Toth B, Aleman M, Brosnan RJ, Dickinson PJ, Conley AJ, Stanley SD, Nogradi N, Williams CD, Madigan JE. PMID: 23176413.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    30. Solubility of haloether anesthetics in human and animal blood. Anesthesiology. 2012 Jul; 117(1):48-55. Soares JH, Brosnan RJ, Fukushima FB, Hodges J, Liu H. PMID: 22510863.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    31. Increased NMDA receptor inhibition at an increased Sevoflurane MAC. BMC Anesthesiol. 2012 Jun 06; 12:9. Brosnan RJ, Thiesen R. PMID: 22672766.
      View in: PubMed   Mentions: 4     Fields:    
    32. Effects of hypercapnic hyperpnea on recovery from isoflurane or sevoflurane anesthesia in horses. Vet Anaesth Analg. 2012 Jul; 39(4):335-44. Brosnan RJ, Steffey EP, Escobar A. PMID: 22574839.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    33. The effects of multitasking on psychological stress reactivity in recreational users of cannabis and MDMA. Hum Psychopharmacol. 2012 Mar; 27(2):167-76. Wetherell MA, Atherton K, Grainger J, Brosnan R, Scholey AB. PMID: 22389081.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    34. Effects of butorphanol on the minimum anesthetic concentration for sevoflurane in guineafowl (Numida meleagris). Am J Vet Res. 2012 Feb; 73(2):183-8. Escobar A, Valadão CA, Brosnan RJ, Denicol AC, Flôres FN, Thiesen R, Coelho CM. PMID: 22280376.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    35. Scintigraphic evaluation of intra-arterial and intravenous regional limb perfusion of allogeneic bone marrow-derived mesenchymal stem cells in the normal equine distal limb using (99m) Tc-HMPAO. Equine Vet J. 2012 Sep; 44(5):594-9. Sole A, Spriet M, Galuppo LD, Padgett KA, Borjesson DL, Wisner ER, Brosnan RJ, Vidal MA. PMID: 22212017.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    36. Anesthetic induction with guaifenesin and propofol in adult horses. Am J Vet Res. 2011 Dec; 72(12):1569-75. Brosnan RJ, Steffey EP, Escobar A, Palazoglu M, Fiehn O. PMID: 22126682.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    37. Use of naltrexone to antagonize high doses of remifentanil in cats: a dose-finding study. Vet Anaesth Analg. 2011 Nov; 38(6):594-7. Pypendop BH, Brosnan RJ, Ilkiw JE. PMID: 21988815.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCTClinical Trials
    38. GABA(A) receptor antagonism increases NMDA receptor inhibition by isoflurane at a minimum alveolar concentration. Vet Anaesth Analg. 2011 May; 38(3):231-9. Brosnan RJ. PMID: 21492389.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    39. Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP. Proc Natl Acad Sci U S A. 2011 Mar 22; 108(12):5093-7. Inceoglu B, Wagner K, Schebb NH, Morisseau C, Jinks SL, Ulu A, Hegedus C, Rose T, Brosnan R, Hammock BD. PMID: 21383170.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    40. Repetitive stimulation of the common peroneal nerve as a diagnostic aid for botulism in foals. J Vet Intern Med. 2011 Mar-Apr; 25(2):365-72. Aleman M, Williams DC, Jorge NE, Magdesian KG, Brosnan RJ, Feary DJ, Hilton HG, Kozikowski TA, Higgins JK, Madigan JE, Lecouteur RA. PMID: 21314725.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    41. Does anesthetic additivity imply a similar molecular mechanism of anesthetic action at N-methyl-D-aspartate receptors? Anesth Analg. 2011 Mar; 112(3):568-73. Brosnan RJ, Pham TL. PMID: 21233494.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    42. Effects of isoflurane anesthesia on cerebrovascular autoregulation in horses. Am J Vet Res. 2011 Jan; 72(1):18-24. Brosnan RJ, Steffey EP, LeCouteur RA, Esteller-Vico A, Vaughan B, Liu IK. PMID: 21194331.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    43. The relationship between digital perfusion pressure and hoof lamellar blood flow in isoflurane-anesthetized horses. Res Vet Sci. 2011 Feb; 90(1):138-45. Brosnan RJ, Steffey EP, Esteller-Vico A, Vaughan B, Liu IK. PMID: 20627330.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    44. Use of propofol-xylazine and the Anderson Sling Suspension System for recovery of horses from desflurane anesthesia. Vet Surg. 2009 Dec; 38(8):927-33. Steffey EP, Brosnan RJ, Galuppo LD, Mama KR, Imai A, Maxwell LK, Cole CA, Stanley SD. PMID: 20017849.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    45. Sedative effects of propofol in horses. Vet Anaesth Analg. 2009 Sep; 36(5):421-5. Brosnan RJ, Steffey EP. PMID: 19709045.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    46. Effects of remifentanil on measures of anesthetic immobility and analgesia in cats. Am J Vet Res. 2009 Sep; 70(9):1065-71. Brosnan RJ, Pypendop BH, Siao KT, Stanley SD. PMID: 19719420.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    47. Effect of administration of propofol and xylazine hydrochloride on recovery of horses after four hours of anesthesia with desflurane. Am J Vet Res. 2009 Aug; 70(8):956-63. Steffey EP, Mama KR, Brosnan RJ, Imai A, Maxwell LK, Cole CA, Stanley SD. PMID: 19645576.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCTClinical Trials
    48. Safety and efficacy of intramuscular propofol administration in rats. Vet Anaesth Analg. 2008 Nov; 35(6):495-500. McKune CM, Brosnan RJ, Dark MJ, Haldorson GJ. PMID: 18980630.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    49. Carbon dioxide negatively modulates N-methyl-D-aspartate receptors. Br J Anaesth. 2008 Nov; 101(5):673-9. Brosnan RJ, Pham TL. PMID: 18791188.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    50. Effects of head-down positioning on regional central nervous system perfusion in isoflurane-anesthetized horses. Am J Vet Res. 2008 Jun; 69(6):737-43. Brosnan RJ, Esteller-Vico A, Steffey EP, LeCouteur RA, Liu IK, Vaughan B. PMID: 18518653.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    51. Pharmacokinetics of remifentanil in conscious cats and cats anesthetized with isoflurane. Am J Vet Res. 2008 Apr; 69(4):531-6. Pypendop BH, Brosnan RJ, Siao KT, Stanley SD. PMID: 18380586.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    52. Anesthetic properties of the ketone bodies beta-hydroxybutyric acid and acetone. Anesth Analg. 2007 Sep; 105(3):673-9. Yang L, Zhao J, Milutinovic PS, Brosnan RJ, Eger EI, Sonner JM. PMID: 17717222.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    53. The plasticizer di(2-ethylhexyl) phthalate modulates gamma-aminobutyric acid type A and glycine receptor function. Anesth Analg. 2007 Aug; 105(2):393-6. Yang L, Milutinovic PS, Brosnan RJ, Eger EI, Sonner JM. PMID: 17646496.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    54. Anesthetic properties of carbon dioxide in the rat. Anesth Analg. 2007 Jul; 105(1):103-6. Brosnan RJ, Eger EI, Laster MJ, Sonner JM. PMID: 17578964.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    55. Ammonia has anesthetic properties. Anesth Analg. 2007 Jun; 104(6):1430-3, table of contents. Brosnan RJ, Yang L, Milutinovic PS, Zhao J, Laster MJ, Eger EI, Sonner JM. PMID: 17513636.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    56. Pharmacokinetics of inhaled anesthetics in green iguanas (Iguana iguana). Am J Vet Res. 2006 Oct; 67(10):1670-4. Brosnan RJ, Pypendop BH, Barter LS, Hawkins MG. PMID: 17014314.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCTClinical Trials
    57. A technique to depress desflurane vapor pressure. Vet Anaesth Analg. 2006 Sep; 33(5):275-80. Brosnan RJ, Pypendop BH. PMID: 16916349.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    58. Chirality in anesthesia II: stereoselective modulation of ion channel function by secondary alcohol enantiomers. Anesth Analg. 2006 Jul; 103(1):86-91, table of contents. Brosnan R, Gong D, Cotten J, Keshavaprasad B, Yost CS, Eger EI, Sonner JM. PMID: 16790632.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    59. The minimum alveolar anesthetic concentration of 2-, 3-, and 4-alcohols and ketones in rats: relevance to anesthetic mechanisms. Anesth Analg. 2006 May; 102(5):1419-26. Won A, Oh I, Liao M, Sonner JM, Harris RA, Laster MJ, Brosnan R, Trudell JR, Eger EI. PMID: 16632820.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    60. Median effective dose of isoflurane, sevoflurane, and desflurane in green iguanas. Am J Vet Res. 2006 Mar; 67(3):392-7. Barter LS, Hawkins MG, Brosnan RJ, Antognini JF, Pypendop BH. PMID: 16506898.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCTClinical Trials
    61. Hypothermia decreases ethanol MAC in rats. J Anesth. 2006; 20(3):247-50. Won A, Oh I, Brosnan R, Eger EI, Sonner JM. PMID: 16897251.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    62. Rate of change of oxygen concentration for a large animal circle anesthetic system. Am J Vet Res. 2005 Oct; 66(10):1675-8. Solano AM, Brosnan RJ, Steffey EP. PMID: 16273896.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    63. Malignant hyperthermia in a horse anesthetized with halothane. J Vet Intern Med. 2005 May-Jun; 19(3):363-6. Aleman M, Brosnan RJ, Williams DC, LeCouteur RA, Imai A, Tharp BR, Steffey EP. PMID: 15954554.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    64. Intracranial elastance in isoflurane-anesthetized horses. Am J Vet Res. 2004 Aug; 65(8):1042-6. Brosnan RJ, LeCouteur RA, Steffey EP, Imai A, Farver TB. PMID: 15334836.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    65. Effects of duration of isoflurane anesthesia and mode of ventilation on intracranial and cerebral perfusion pressures in horses. Am J Vet Res. 2003 Nov; 64(11):1444-8. Brosnan RJ, Steffey EP, LeCouteur RA, Farver TB, Imai A. PMID: 14620783.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    66. Assessment of halothane and sevoflurane anesthesia in spontaneously breathing rats. Am J Vet Res. 2003 Apr; 64(4):470-4. Steffey MA, Brosnan RJ, Steffey EP. PMID: 12693538.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCTClinical Trials
    67. Effects of ventilation and isoflurane end-tidal concentration on intracranial and cerebral perfusion pressures in horses. Am J Vet Res. 2003 Jan; 64(1):21-5. Brosnan RJ, Steffey EP, LeCouteur RA, Imai A, Farver TB, Kortz GD. PMID: 12518873.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    68. Direct measurement of intracranial pressure in adult horses. Am J Vet Res. 2002 Sep; 63(9):1252-6. Brosnan RJ, LeCouteur RA, Steffey EP, Imai A, Kortz GD. PMID: 12224855.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCTClinical Trials
    69. Effects of body position on intracranial and cerebral perfusion pressures in isoflurane-anesthetized horses. J Appl Physiol (1985). 2002 Jun; 92(6):2542-6. Brosnan RJ, Steffey EP, LeCouteur RA, Imai A, Farver TB, Kortz GD. PMID: 12015371.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
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