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Robert J Brosnan

Title(s)Professor, SCHOOL OF VETERINARY MEDICINE
SchoolUniversity of California, Davis
Phone530-754-6476
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    Collapse Research 
    Collapse Research Activities and Funding
    Does Anesthetic Solubility Determine Receptor Specificity?
    NIH/NIGMS R01GM092821Sep 30, 2010 - Aug 31, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Cenani A, Brosnan RJ, Knych HK. In vitro and in vivo GABAA Receptor Interaction of the Propanidid Metabolite 4-(2-[Diethylamino]-2-Oxoethoxy)-3-Methoxy-Benzeneacetic Acid. Pharmacology. 2019; 103(1-2):10-16. PMID: 30332672.
      View in: PubMed
    2. Brosnan RJ, Pham TL. Anesthetic-sensitive ion channel modulation is associated with a molar water solubility cut-off. BMC Pharmacol Toxicol. 2018 Sep 14; 19(1):57. PMID: 30217234.
      View in: PubMed
    3. Guedes AGP, Aristizabal F, Sole A, Adedeji A, Brosnan R, Knych H, Yang J, Hwang SH, Morisseau C, Hammock BD. Pharmacokinetics and antinociceptive effects of the soluble epoxide hydrolase inhibitor t-TUCB in horses with experimentally induced radiocarpal synovitis. J Vet Pharmacol Ther. 2018 Apr; 41(2):230-238. PMID: 29067696.
      View in: PubMed
    4. Cenani A, Brosnan RJ, Madigan S, Knych HK, Madigan JE. Pharmacokinetics and pharmacodynamics of intravenous romifidine and propranolol administered alone or in combination for equine sedation. Vet Anaesth Analg. 2017 Jan; 44(1):86-97. PMID: 27426730.
      View in: PubMed
    5. Espinosa P, Le Jeune SS, Cenani A, Kass PH, Brosnan RJ. Investigation of perioperative and anesthetic variables affecting short-term survival of horses with small intestinal strangulating lesions. Vet Surg. 2017 Apr; 46(3):345-353. PMID: 28152199.
      View in: PubMed
    6. Brosnan RJ, Fukushima FB, Pham TL. Anesthetic synergy between two n-alkanes. Vet Anaesth Analg. 2017 May; 44(3):577-588. PMID: 28583773.
      View in: PubMed
    7. Brosnan RJ, Pham TL. GABAA Receptor Modulation by Phenyl Ring Compounds Is Associated with a Water Solubility Cut-Off Value. Pharmacology. 2016; 98(1-2):13-9. PMID: 26986632.
      View in: PubMed
    8. Williams DC, Brosnan RJ, Fletcher DJ, Aleman M, Holliday TA, Tharp B, Kass PH, LeCouteur RA, Steffey EP. Qualitative and Quantitative Characteristics of the Electroencephalogram in Normal Horses during Administration of Inhaled Anesthesia. J Vet Intern Med. 2016 Jan-Feb; 30(1):289-303. PMID: 26714626.
      View in: PubMed
    9. Esteller-Vico A, Liu IK, Vaughan B, Steffey EP, Brosnan RJ. Effects of estradiol on uterine perfusion in anesthetized cyclic mares affected with uterine vascular elastosis. Anim Reprod Sci. 2016 Jan; 164:57-63. PMID: 26642749.
      View in: PubMed
    10. Williams DC, Aleman MR, Brosnan RJ, Fletcher DJ, Holliday TA, Tharp B, Kass PH, Steffey EP, LeCouteur RA. Electroencephalogram of Healthy Horses During Inhaled Anesthesia. J Vet Intern Med. 2016 Jan-Feb; 30(1):304-8. PMID: 26376458.
      View in: PubMed
    11. Tearney CC, Guedes AG, Brosnan RJ. Equivalence between invasive and oscillometric blood pressures at different anatomic locations in healthy normotensive anaesthetised horses. Equine Vet J. 2016 May; 48(3):357-61. PMID: 25790220.
      View in: PubMed
    12. Valente AC, Brosnan RJ, Guedes AG. Desflurane and sevoflurane elimination kinetics and recovery quality in horses. Am J Vet Res. 2015 Mar; 76(3):201-7. PMID: 25710755.
      View in: PubMed
    13. Esteller-Vico A, Liu IK, Vaughan B, Steffey EP, Brosnan RJ. Effects of vascular elastosis on uterine blood flow and perfusion in anesthetized mares. Theriogenology. 2015 Apr 01; 83(6):988-94. PMID: 25543154.
      View in: PubMed
    14. Brosnan RJ, Pham TL. Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation. BMC Pharmacol Toxicol. 2014 Nov 19; 15:62. PMID: 25410726.
      View in: PubMed
    15. Soares JH, Brosnan RJ, Smith A, Mayhew PD. Rabbit model of chest wall rigidity induced by fentanyl and the effects of apomorphine. Respir Physiol Neurobiol. 2014 Oct 01; 202:50-2. PMID: 25093961.
      View in: PubMed
    16. Smith AL, Mayhew PD, Soares JH, Kass PH, Brosnan RJ. Hilar closure using staplers or Hem-o-lok clips in a rabbit model. J Surg Res. 2014 Dec; 192(2):616-20. PMID: 25167784.
      View in: PubMed
    17. Wiese AJ, Brosnan RJ, Barter LS. Effects of acetylcholinesterase inhibition on quality of recovery from isoflurane-induced anesthesia in horses. Am J Vet Res. 2014 Mar; 75(3):223-30. PMID: 24564307.
      View in: PubMed
    18. Guedes AG, Knych HK, Soares JH, Brosnan RJ. Pharmacokinetics and physiological effects of repeated oral administrations of tramadol in horses. J Vet Pharmacol Ther. 2014 Jun; 37(3):269-78. PMID: 24180699.
      View in: PubMed
    19. Aleman M, Williams DC, Brosnan RJ, Nieto JE, Pickles KJ, Berger J, Lecouteur RA, Holliday TA, Madigan JE. Sensory nerve conduction and somatosensory evoked potentials of the trigeminal nerve in horses with idiopathic headshaking. J Vet Intern Med. 2013 Nov-Dec; 27(6):1571-80. PMID: 24107198.
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    20. Ferreira TH, Brosnan RJ, Shilo-Benjamini Y, Moore SB, Hollingsworth SR. Effects of ketamine, propofol, or thiopental administration on intraocular pressure and qualities of induction of and recovery from anesthesia in horses. Am J Vet Res. 2013 Aug; 74(8):1070-7. PMID: 23879844.
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    21. Pypendop BH, Brosnan RJ, Majewski-Tiedeken CR, Stanley SD, Ilkiw JE. Pharmacokinetics of fentanyl, alfentanil, and sufentanil in isoflurane-anesthetized cats. J Vet Pharmacol Ther. 2014 Feb; 37(1):13-7. PMID: 23895731.
      View in: PubMed
    22. Woodhouse KJ, Brosnan RJ, Nguyen KQ, Moniz GW, Galuppo LD. Effects of postanesthetic sedation with romifidine or xylazine on quality of recovery from isoflurane anesthesia in horses. J Am Vet Med Assoc. 2013 Feb 15; 242(4):533-9. PMID: 23363287.
      View in: PubMed
    23. Brosnan RJ. Inhaled anesthetics in horses. Vet Clin North Am Equine Pract. 2013 Apr; 29(1):69-87. PMID: 23498046.
      View in: PubMed
    24. Brosnan RJ, Pypendop BH, Majewski-Tiedeken CR, Shilo-Benjamini Y, Ilkiw JE. Naltrexone does not affect isoflurane minimum alveolar concentration in cats. Vet Anaesth Analg. 2013 Mar; 40(2):225-8. PMID: 23279646.
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    25. Kelleher ME, Brosnan RJ, Kass PH, le Jeune SS. Use of physiologic and arterial blood gas variables to predict short-term survival in horses with large colon volvulus. Vet Surg. 2013 Jan; 42(1):107-13. PMID: 23216048.
      View in: PubMed
    26. Toth B, Aleman M, Brosnan RJ, Dickinson PJ, Conley AJ, Stanley SD, Nogradi N, Williams CD, Madigan JE. Evaluation of squeeze-induced somnolence in neonatal foals. Am J Vet Res. 2012 Dec; 73(12):1881-9. PMID: 23176413.
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    27. Soares JH, Brosnan RJ, Fukushima FB, Hodges J, Liu H. Solubility of haloether anesthetics in human and animal blood. Anesthesiology. 2012 Jul; 117(1):48-55. PMID: 22510863.
      View in: PubMed
    28. Brosnan RJ, Thiesen R. Increased NMDA receptor inhibition at an increased Sevoflurane MAC. BMC Anesthesiol. 2012 Jun 06; 12:9. PMID: 22672766.
      View in: PubMed
    29. Brosnan RJ, Steffey EP, Escobar A. Effects of hypercapnic hyperpnea on recovery from isoflurane or sevoflurane anesthesia in horses. Vet Anaesth Analg. 2012 Jul; 39(4):335-44. PMID: 22574839.
      View in: PubMed
    30. Wetherell MA, Atherton K, Grainger J, Brosnan R, Scholey AB. The effects of multitasking on psychological stress reactivity in recreational users of cannabis and MDMA. Hum Psychopharmacol. 2012 Mar; 27(2):167-76. PMID: 22389081.
      View in: PubMed
    31. Escobar A, Valadão CA, Brosnan RJ, Denicol AC, Flôres FN, Thiesen R, Coelho CM. Effects of butorphanol on the minimum anesthetic concentration for sevoflurane in guineafowl (Numida meleagris). Am J Vet Res. 2012 Feb; 73(2):183-8. PMID: 22280376.
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    32. Sole A, Spriet M, Galuppo LD, Padgett KA, Borjesson DL, Wisner ER, Brosnan RJ, Vidal MA. Scintigraphic evaluation of intra-arterial and intravenous regional limb perfusion of allogeneic bone marrow-derived mesenchymal stem cells in the normal equine distal limb using (99m) Tc-HMPAO. Equine Vet J. 2012 Sep; 44(5):594-9. PMID: 22212017.
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    33. Brosnan RJ, Steffey EP, Escobar A, Palazoglu M, Fiehn O. Anesthetic induction with guaifenesin and propofol in adult horses. Am J Vet Res. 2011 Dec; 72(12):1569-75. PMID: 22126682.
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    34. Pypendop BH, Brosnan RJ, Ilkiw JE. Use of naltrexone to antagonize high doses of remifentanil in cats: a dose-finding study. Vet Anaesth Analg. 2011 Nov; 38(6):594-7. PMID: 21988815.
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    35. Brosnan RJ. GABA(A) receptor antagonism increases NMDA receptor inhibition by isoflurane at a minimum alveolar concentration. Vet Anaesth Analg. 2011 May; 38(3):231-9. PMID: 21492389.
      View in: PubMed
    36. Inceoglu B, Wagner K, Schebb NH, Morisseau C, Jinks SL, Ulu A, Hegedus C, Rose T, Brosnan R, Hammock BD. Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP. Proc Natl Acad Sci U S A. 2011 Mar 22; 108(12):5093-7. PMID: 21383170.
      View in: PubMed
    37. Aleman M, Williams DC, Jorge NE, Magdesian KG, Brosnan RJ, Feary DJ, Hilton HG, Kozikowski TA, Higgins JK, Madigan JE, Lecouteur RA. Repetitive stimulation of the common peroneal nerve as a diagnostic aid for botulism in foals. J Vet Intern Med. 2011 Mar-Apr; 25(2):365-72. PMID: 21314725.
      View in: PubMed
    38. Brosnan RJ, Pham TL. Does anesthetic additivity imply a similar molecular mechanism of anesthetic action at N-methyl-D-aspartate receptors? Anesth Analg. 2011 Mar; 112(3):568-73. PMID: 21233494.
      View in: PubMed
    39. Brosnan RJ, Steffey EP, LeCouteur RA, Esteller-Vico A, Vaughan B, Liu IK. Effects of isoflurane anesthesia on cerebrovascular autoregulation in horses. Am J Vet Res. 2011 Jan; 72(1):18-24. PMID: 21194331.
      View in: PubMed
    40. Brosnan RJ, Steffey EP, Esteller-Vico A, Vaughan B, Liu IK. The relationship between digital perfusion pressure and hoof lamellar blood flow in isoflurane-anesthetized horses. Res Vet Sci. 2011 Feb; 90(1):138-45. PMID: 20627330.
      View in: PubMed
    41. Steffey EP, Brosnan RJ, Galuppo LD, Mama KR, Imai A, Maxwell LK, Cole CA, Stanley SD. Use of propofol-xylazine and the Anderson Sling Suspension System for recovery of horses from desflurane anesthesia. Vet Surg. 2009 Dec; 38(8):927-33. PMID: 20017849.
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    42. Brosnan RJ, Steffey EP. Sedative effects of propofol in horses. Vet Anaesth Analg. 2009 Sep; 36(5):421-5. PMID: 19709045.
      View in: PubMed
    43. Brosnan RJ, Pypendop BH, Siao KT, Stanley SD. Effects of remifentanil on measures of anesthetic immobility and analgesia in cats. Am J Vet Res. 2009 Sep; 70(9):1065-71. PMID: 19719420.
      View in: PubMed
    44. Steffey EP, Mama KR, Brosnan RJ, Imai A, Maxwell LK, Cole CA, Stanley SD. Effect of administration of propofol and xylazine hydrochloride on recovery of horses after four hours of anesthesia with desflurane. Am J Vet Res. 2009 Aug; 70(8):956-63. PMID: 19645576.
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    45. McKune CM, Brosnan RJ, Dark MJ, Haldorson GJ. Safety and efficacy of intramuscular propofol administration in rats. Vet Anaesth Analg. 2008 Nov; 35(6):495-500. PMID: 18980630.
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    46. Brosnan RJ, Pham TL. Carbon dioxide negatively modulates N-methyl-D-aspartate receptors. Br J Anaesth. 2008 Nov; 101(5):673-9. PMID: 18791188.
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    47. Brosnan RJ, Esteller-Vico A, Steffey EP, LeCouteur RA, Liu IK, Vaughan B. Effects of head-down positioning on regional central nervous system perfusion in isoflurane-anesthetized horses. Am J Vet Res. 2008 Jun; 69(6):737-43. PMID: 18518653.
      View in: PubMed
    48. Pypendop BH, Brosnan RJ, Siao KT, Stanley SD. Pharmacokinetics of remifentanil in conscious cats and cats anesthetized with isoflurane. Am J Vet Res. 2008 Apr; 69(4):531-6. PMID: 18380586.
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    49. Yang L, Zhao J, Milutinovic PS, Brosnan RJ, Eger EI, Sonner JM. Anesthetic properties of the ketone bodies beta-hydroxybutyric acid and acetone. Anesth Analg. 2007 Sep; 105(3):673-9. PMID: 17717222.
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    50. Yang L, Milutinovic PS, Brosnan RJ, Eger EI, Sonner JM. The plasticizer di(2-ethylhexyl) phthalate modulates gamma-aminobutyric acid type A and glycine receptor function. Anesth Analg. 2007 Aug; 105(2):393-6. PMID: 17646496.
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    51. Brosnan RJ, Eger EI, Laster MJ, Sonner JM. Anesthetic properties of carbon dioxide in the rat. Anesth Analg. 2007 Jul; 105(1):103-6. PMID: 17578964.
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    52. Brosnan RJ, Yang L, Milutinovic PS, Zhao J, Laster MJ, Eger EI, Sonner JM. Ammonia has anesthetic properties. Anesth Analg. 2007 Jun; 104(6):1430-3, table of contents. PMID: 17513636.
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    53. Brosnan RJ, Pypendop BH, Barter LS, Hawkins MG. Pharmacokinetics of inhaled anesthetics in green iguanas (Iguana iguana). Am J Vet Res. 2006 Oct; 67(10):1670-4. PMID: 17014314.
      View in: PubMed
    54. Brosnan RJ, Pypendop BH. A technique to depress desflurane vapor pressure. Vet Anaesth Analg. 2006 Sep; 33(5):275-80. PMID: 16916349.
      View in: PubMed
    55. Brosnan R, Gong D, Cotten J, Keshavaprasad B, Yost CS, Eger EI, Sonner JM. Chirality in anesthesia II: stereoselective modulation of ion channel function by secondary alcohol enantiomers. Anesth Analg. 2006 Jul; 103(1):86-91, table of contents. PMID: 16790632.
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    56. Won A, Oh I, Liao M, Sonner JM, Harris RA, Laster MJ, Brosnan R, Trudell JR, Eger EI. The minimum alveolar anesthetic concentration of 2-, 3-, and 4-alcohols and ketones in rats: relevance to anesthetic mechanisms. Anesth Analg. 2006 May; 102(5):1419-26. PMID: 16632820.
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    57. Barter LS, Hawkins MG, Brosnan RJ, Antognini JF, Pypendop BH. Median effective dose of isoflurane, sevoflurane, and desflurane in green iguanas. Am J Vet Res. 2006 Mar; 67(3):392-7. PMID: 16506898.
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    58. Won A, Oh I, Brosnan R, Eger EI, Sonner JM. Hypothermia decreases ethanol MAC in rats. J Anesth. 2006; 20(3):247-50. PMID: 16897251.
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    59. Solano AM, Brosnan RJ, Steffey EP. Rate of change of oxygen concentration for a large animal circle anesthetic system. Am J Vet Res. 2005 Oct; 66(10):1675-8. PMID: 16273896.
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    60. Aleman M, Brosnan RJ, Williams DC, LeCouteur RA, Imai A, Tharp BR, Steffey EP. Malignant hyperthermia in a horse anesthetized with halothane. J Vet Intern Med. 2005 May-Jun; 19(3):363-6. PMID: 15954554.
      View in: PubMed
    61. Brosnan RJ, LeCouteur RA, Steffey EP, Imai A, Farver TB. Intracranial elastance in isoflurane-anesthetized horses. Am J Vet Res. 2004 Aug; 65(8):1042-6. PMID: 15334836.
      View in: PubMed
    62. Brosnan RJ, Steffey EP, LeCouteur RA, Farver TB, Imai A. Effects of duration of isoflurane anesthesia and mode of ventilation on intracranial and cerebral perfusion pressures in horses. Am J Vet Res. 2003 Nov; 64(11):1444-8. PMID: 14620783.
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    63. Steffey MA, Brosnan RJ, Steffey EP. Assessment of halothane and sevoflurane anesthesia in spontaneously breathing rats. Am J Vet Res. 2003 Apr; 64(4):470-4. PMID: 12693538.
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    64. Brosnan RJ, Steffey EP, LeCouteur RA, Imai A, Farver TB, Kortz GD. Effects of ventilation and isoflurane end-tidal concentration on intracranial and cerebral perfusion pressures in horses. Am J Vet Res. 2003 Jan; 64(1):21-5. PMID: 12518873.
      View in: PubMed
    65. Brosnan RJ, LeCouteur RA, Steffey EP, Imai A, Kortz GD. Direct measurement of intracranial pressure in adult horses. Am J Vet Res. 2002 Sep; 63(9):1252-6. PMID: 12224855.
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    66. Brosnan RJ, Steffey EP, LeCouteur RA, Imai A, Farver TB, Kortz GD. Effects of body position on intracranial and cerebral perfusion pressures in isoflurane-anesthetized horses. J Appl Physiol (1985). 2002 Jun; 92(6):2542-6. PMID: 12015371.
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