Christophe Morisseau

Title(s)Researcher, Entomology
SchoolCollege of Agricultural and Environmental Sciences
AddressOne Shield Avenue
CA 95616
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. The Role of Autophagy in Human Uveal Melanoma and the Development of Potential Disease Biomarkers and Novel Therapeutic Paradigms. Biomedicines. 2024 Feb 19; 12(2). Wang JZ, Paulus P, Niu Y, Zhu L, Morisseau C, Rawling T, Murray M, Hammock BD, Zhou F. PMID: 38398064; PMCID: PMC10886749.
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    2. Design and Synthesis of Dual-Targeting Inhibitors of sEH and HDAC6 for the Treatment of Neuropathic Pain and Lipopolysaccharide-Induced Mortality. J Med Chem. 2024 Feb 08; 67(3):2095-2117. Chen Y, Sun J, Tong H, Wang J, Cao R, Xu H, Chen L, Morisseau C, Zhang M, Shi Y, Han C, Zhuang J, Jing Y, Liu Z, Hammock BD, Chen G. PMID: 38236416.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. Fluorine and chlorine substituted adamantyl-urea as molecular tools for inhibition of human soluble epoxide hydrolase with picomolar efficacy. J Enzyme Inhib Med Chem. 2023 Dec; 38(1):2274797. Burmistrov VV, Morisseau C, Danilov DV, Gladkikh BP, D'yachenko VS, Zefirov NA, Zefirova ON, Butov GM, Hammock BD. PMID: 37975322; PMCID: PMC11003477.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Biosynthesis of magnetosome-nanobody complex in Magnetospirillum gryphiswaldense MSR-1 and a magnetosome-nanobody-based enzyme-linked immunosorbent assay for the detection of tetrabromobisphenol A in water. Anal Bioanal Chem. 2024 Jan; 416(1):141-149. Wu S, Tian J, Xue X, Ma F, Li QX, Morisseau C, Hammock BD, Xu T. PMID: 37934249; PMCID: PMC10829939.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    5. Soluble epoxide hydrolase-targeting PROTAC activates AMPK and inhibits endoplasmic reticulum stress. Biomed Pharmacother. 2023 Dec; 168:115667. Peyman M, Barroso E, Turcu AL, Estrany F, Smith D, Jurado-Aguilar J, Rada P, Morisseau C, Hammock BD, Valverde ÁM, Palomer X, Galdeano C, Vázquez S, Vázquez-Carrera M. PMID: 37826940; PMCID: PMC10786198.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    6. The Generation of a Nanobody-Based ELISA for Human Microsomal Epoxide Hydrolase. Int J Mol Sci. 2023 Sep 28; 24(19). He Q, McCoy MR, Qi M, Morisseau C, Yang H, Xu C, Shey R, Goodman MC, Zhao S, Hammock BD. PMID: 37834144; PMCID: PMC10572367.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Development of a sandwich ELISA for the specific quantitation of hemagglutinin (HA)-tagged proteins during their inducible expression in Escherichia coli. Anal Bioanal Chem. 2023 Sep; 415(23):5563-5574. Yin Z, He Q, Yang H, Morisseau C, El-Sheikh EA, Li D, Hammock BD. PMID: 37505234; PMCID: PMC10473979.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    8. Effects of Individual Circulating FFAs on Plasma and Hepatic FFA Epoxides, Diols, and Epoxide-Diol Ratios as Indices of Soluble Epoxide Hydrolase Activity. Int J Mol Sci. 2023 Jun 28; 24(13). Oh YT, Yang J, Morisseau C, He Q, Hammock B, Youn JH. PMID: 37445935; PMCID: PMC10341844.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    9. Genetic deletion or pharmacological inhibition of soluble epoxide hydrolase attenuated particulate matter 2.5 exposure mediated lung injury. J Hazard Mater. 2023 09 15; 458:131890. Zhang J, Zhang WH, Morisseau C, Zhang M, Dong HJ, Zhu QM, Huo XK, Sun CP, Hammock BD, Ma XC. PMID: 37406527; PMCID: PMC10699546.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    10. Aflatoxin B1 Increases Soluble Epoxide Hydrolase in the Brain and Induces Neuroinflammation and Dopaminergic Neurotoxicity. Int J Mol Sci. 2023 Jun 09; 24(12). Wang W, Wang Y, Wagner KM, Lee RD, Hwang SH, Morisseau C, Wulff H, Hammock BD. PMID: 37373086; PMCID: PMC10298596.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    11. Regulatory lipid vicinal diols counteract the biological activity of epoxy fatty acids and can act as biomarkers and mechanisms for disease progression. Pharmacol Ther. 2023 08; 248:108454. McReynolds C, Hammock B, Morisseau C. PMID: 37268114; PMCID: PMC10529401.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    12. Quantification of soluble epoxide hydrolase inhibitors in experimental and clinical samples using the nanobody-based ELISA. J Pharm Anal. 2023 Sep; 13(9):1013-1023. Yang H, Qi M, He Q, Hwang SH, Yang J, McCoy M, Morisseau C, Zhao S, Hammock BD. PMID: 37842656; PMCID: PMC10568103.
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    13. Screening and Biological Evaluation of Soluble Epoxide Hydrolase Inhibitors: Assessing the Role of Hydrophobicity in the Pharmacophore-Guided Search of Novel Hits. J Chem Inf Model. 2023 05 22; 63(10):3209-3225. Vázquez J, Ginex T, Herrero A, Morisseau C, Hammock BD, Luque FJ. PMID: 37141492; PMCID: PMC10207366.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    14. Neuroprotective effect of herbal extracts inhibiting soluble epoxide hydrolase (sEH) and cyclooxygenase (COX) against chemotherapy-induced cognitive impairment in mice. Biochem Biophys Res Commun. 2023 07 30; 667:64-72. Kulkarni R, Mehta R, Goswami SK, Hammock BD, Morisseau C, Hwang SH, Mallappa O, Azeemuddin MM, Rafiq M, S N M. PMID: 37209564; PMCID: PMC10849156.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    15. Mix-and-Read Nanobody-Based Sandwich Homogeneous Split-Luciferase Assay for the Rapid Detection of Human Soluble Epoxide Hydrolase. Anal Chem. 2023 04 11; 95(14):6038-6045. He Q, McCoy MR, Yang H, Lin M, Cui X, Zhao S, Morisseau C, Li D, Hammock BD. PMID: 36972550; PMCID: PMC10335774.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    16. PROTAC-Mediated Selective Degradation of Cytosolic Soluble Epoxide Hydrolase Enhances ER Stress Reduction. ACS Chem Biol. 2023 04 21; 18(4):884-896. Wang Y, Morisseau C, Takamura A, Wan D, Li D, Sidoli S, Yang J, Wolan DW, Hammock BD, Kitamura S. PMID: 36947831; PMCID: PMC10586715.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    17. Development of a Genetically Encoded Magnetic Platform in Magnetospirillum gryphiswaldense MSR-1 for Downstream Processing of Protein Expression System. Res Sq. 2023 Mar 13. Wu S, Tian J, Xue X, Tang Z, Huang Z, Hammock BD, Morisseau C, Li QX, Xu T. PMID: 36993437; PMCID: PMC10055543.
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    18. Soluble Epoxide Hydrolase Contributes to Cell Senescence and ER Stress in Aging Mice Colon. Int J Mol Sci. 2023 Feb 26; 24(5). Wang W, Wagner KM, Wang Y, Singh N, Yang J, He Q, Morisseau C, Hammock BD. PMID: 36901999; PMCID: PMC10003560.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    19. Macrophage Inactivation by Small Molecule Wedelolactone via Targeting sEH for the Treatment of LPS-Induced Acute Lung Injury. ACS Cent Sci. 2023 Mar 22; 9(3):440-456. Zhang J, Zhang M, Huo XK, Ning J, Yu ZL, Morisseau C, Sun CP, Hammock BD, Ma XC. PMID: 36968547; PMCID: PMC10037491.
      View in: PubMed   Mentions: 8  
    20. Inhibition of Soluble Epoxide Hydrolase Does Not Promote or Aggravate Pulmonary Hypertension in Rats. Cells. 2023 02 20; 12(4). Leuillier M, Platel V, Tu L, Feugray G, Thuillet R, Groussard D, Messaoudi H, Ottaviani M, Chelgham M, Nicol L, Mulder P, Humbert M, Richard V, Morisseau C, Brunel V, Duflot T, Guignabert C, Bellien J. PMID: 36831332; PMCID: PMC9954493.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    21. Structure-Directed Discovery of Potent Soluble Epoxide Hydrolase Inhibitors for the Treatment of Inflammatory Diseases. J Med Chem. 2023 02 23; 66(4):2979-3009. Chen Y, Chen L, Xu H, Cao R, Morisseau C, Zhang M, Shi Y, Hammock BD, Wang J, Zhuang J, Liu Z, Chen G. PMID: 36689364; PMCID: PMC9974930.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    22. Adamantyl-ureas with pyrazoles substituted by fluoroalkanes as soluble epoxide hydrolase inhibitors. J Fluor Chem. 2023 Feb; 266. Burmistrov VV, Morisseau C, Shkineva TK, Danilov DV, Gladkikh B, Butov GM, Fayzullin RR, Dutova TY, Hammock BD, Dalinger IL. PMID: 37638129; PMCID: PMC10457016.
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    23. Novel inhibition of AKR1C3 and androgen receptor axis by PTUPB synergizes enzalutamide treatment in advanced prostate cancer. Oncogene. 2023 02; 42(9):693-707. Yang JC, Xu P, Ning S, Wasielewski LJ, Adomat H, Hwang SH, Morisseau C, Gleave M, Corey E, Gao AC, Lara PN, Evans CP, Hammock BD, Liu C. PMID: 36596844; PMCID: PMC9975039.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    24. Direct targeting of sEH with alisol B alleviated the apoptosis, inflammation, and oxidative stress in cisplatin-induced acute kidney injury. Int J Biol Sci. 2023; 19(1):294-310. Zhang J, Luan ZL, Huo XK, Zhang M, Morisseau C, Sun CP, Hammock BD, Ma XC. PMID: 36594097; PMCID: PMC9760444.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    25. Structure-activity relationship studies of benzothiazole-phenyl analogs as multi-target ligands to alleviate pain without affecting normal behavior. Prostaglandins Other Lipid Mediat. 2023 02; 164:106702. Angelia J, Weng X, Solomatov A, Chin C, Fernandez A, Hudson PK, Morisseau C, Hammock BD, Kandasamy R, Pecic S. PMID: 36529320; PMCID: PMC9879382.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    26. Aflatoxin B1 exposure disrupts the intestinal immune function via a soluble epoxide hydrolase-mediated manner. Ecotoxicol Environ Saf. 2023 Jan 01; 249:114417. Wang W, Wang Y, Yang J, Wagner KM, Hwang SH, Cheng J, Singh N, Edwards P, Morisseau C, Zhang G, Panigrahy D, Hammock BD. PMID: 36525946; PMCID: PMC9879385.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    27. Ureas derived from camphor and fenchone reveal enantiomeric preference of human soluble epoxide hydrolase. Results Chem. 2022 Jan; 4. Burmistrov V, Morisseau C, Pitushkin D, Fayzullin RR, Karlov D, Vernigora A, Kuznetsov Y, Abbas SMH, Butov GM, Hammock BD. PMID: 37601415; PMCID: PMC10438916.
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    28. Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors. J Med Chem. 2022 10 27; 65(20):13660-13680. Codony S, Entrena JM, Calvó-Tusell C, Jora B, González-Cano R, Osuna S, Corpas R, Morisseau C, Pérez B, Barniol-Xicota M, Griñán-Ferré C, Pérez C, Rodríguez-Franco MI, Martínez AL, Loza MI, Pallàs M, Verhelst SHL, Sanfeliu C, Feixas F, Hammock BD, Brea J, Cobos EJ, Vázquez S. PMID: 36222708; PMCID: PMC9620236.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    29. Soluble Epoxide Hydrolase Is Associated with Postprandial Anxiety Decrease in Healthy Adult Women. Int J Mol Sci. 2022 Oct 05; 23(19). Nguyen N, Morisseau C, Li D, Yang J, Lam E, Woodside DB, Hammock BD, Shih PB. PMID: 36233100; PMCID: PMC9569757.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    30. Anti-Inflammatory Activity of Soluble Epoxide Hydrolase Inhibitors Based on Selenoureas Bearing an Adamantane Moiety. Int J Mol Sci. 2022 Sep 14; 23(18). Burmistrov V, Morisseau C, Babkov DA, Golubeva T, Pitushkin D, Sokolova EV, Vasipov V, Kuznetsov Y, Bazhenov SV, Novoyatlova US, Bondarev NA, Manukhov IV, Osipova V, Berberova N, Spasov AA, Butov GM, Hammock BD. PMID: 36142611; PMCID: PMC9501280.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    31. The epoxy fatty acid pathway enhances cAMP in mammalian cells through multiple mechanisms. Prostaglandins Other Lipid Mediat. 2022 10; 162:106662. Matsumoto N, Singh N, Lee KS, Barnych B, Morisseau C, Hammock BD. PMID: 35779854; PMCID: PMC9530012.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    32. Improved ELISA for linoleate-derived diols in human plasma utilizing a polyHRP-based secondary tracer. Anal Methods. 2022 05 13; 14(18):1810-1819. Singh N, Li D, McReynolds CB, Morisseau C, Hammock BD. PMID: 35481804; PMCID: PMC9116231.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    33. The Role of Hydrolases in Biology and Xenobiotics Metabolism. Int J Mol Sci. 2022 Apr 28; 23(9). Morisseau C. PMID: 35563260; PMCID: PMC9105290.
      View in: PubMed   Mentions: 1     Fields:    
    34. CRISPR/Cas9-mediated inactivation of the phosphatase activity of soluble epoxide hydrolase prevents obesity and cardiac ischemic injury. J Adv Res. 2023 01; 43:163-174. Leuillier M, Duflot T, Ménoret S, Messaoudi H, Djerada Z, Groussard D, Denis RGP, Chevalier L, Karoui A, Panthu B, Thiébaut PA, Schmitz-Afonso I, Nobis S, Campart C, Henry T, Sautreuil C, Luquet SH, Beseme O, Féliu C, Peyret H, Nicol L, Henry JP, Renet S, Mulder P, Wan D, Tesson L, Heslan JM, Duché A, Jacques S, Ziegler F, Brunel V, Rautureau GJP, Monteil C, do Rego JL, do Rego JC, Afonso C, Hammock B, Madec AM, Pinet F, Richard V, Anegon I, Guignabert C, Morisseau C, Bellien J. PMID: 36585106; PMCID: PMC9811321.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    35. Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease. J Med Chem. 2022 03 24; 65(6):4909-4925. Codony S, Pont C, Griñán-Ferré C, Di Pede-Mattatelli A, Calvó-Tusell C, Feixas F, Osuna S, Jarné-Ferrer J, Naldi M, Bartolini M, Loza MI, Brea J, Pérez B, Bartra C, Sanfeliu C, Juárez-Jiménez J, Morisseau C, Hammock BD, Pallàs M, Vázquez S, Muñoz-Torrero D. PMID: 35271276; PMCID: PMC8958510.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    36. Kurarinone alleviated Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal model. Proc Natl Acad Sci U S A. 2022 03 01; 119(9). Sun CP, Zhou JJ, Yu ZL, Huo XK, Zhang J, Morisseau C, Hammock BD, Ma XC. PMID: 35217618; PMCID: PMC8892522.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    37. A Fast and Selective Approach for Profiling Vicinal Diols Using Liquid Chromatography-Post Column Derivatization-Double Precursor Ion Scanning Mass Spectrometry. Molecules. 2022 Jan 03; 27(1). Wan D, Morisseau C, Hammock BD, Yang J. PMID: 35011515; PMCID: PMC8747065.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    38. Soluble Epoxide Hydrolase Deletion Limits High-Fat Diet-Induced Inflammation. Front Pharmacol. 2021; 12:778470. Wagner KM, Yang J, Morisseau C, Hammock BD. PMID: 34975481; PMCID: PMC8719166.
      View in: PubMed   Mentions: 2  
    39. 2-(Piperidin-4-yl)acetamides as Potent Inhibitors of Soluble Epoxide Hydrolase with Anti-Inflammatory Activity. Pharmaceuticals (Basel). 2021 Dec 17; 14(12). Martín-López J, Codony S, Bartra C, Morisseau C, Loza MI, Sanfeliu C, Hammock BD, Brea J, Vázquez S. PMID: 34959721; PMCID: PMC8703317.
      View in: PubMed   Mentions: 2  
    40. New Alkoxy- Analogues of Epoxyeicosatrienoic Acids Attenuate Cisplatin Nephrotoxicity In Vitro via Reduction of Mitochondrial Dysfunction, Oxidative Stress, Mitogen-Activated Protein Kinase Signaling, and Caspase Activation. Chem Res Toxicol. 2021 12 20; 34(12):2579-2591. Singh N, Vik A, Lybrand DB, Morisseau C, Hammock BD. PMID: 34817988; PMCID: PMC8853703.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    41. Further exploration of the structure-activity relationship of dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors. Bioorg Med Chem. 2021 12 01; 51:116507. Wilt S, Kodani S, Valencia L, Hudson PK, Sanchez S, Quintana T, Morisseau C, Hammock BD, Kandasamy R, Pecic S. PMID: 34794001; PMCID: PMC8900675.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    42. Species Differences in Metabolism of Soluble Epoxide Hydrolase Inhibitor, EC1728, Highlight the Importance of Clinically Relevant Screening Mechanisms in Drug Development. Molecules. 2021 Aug 19; 26(16). McReynolds CB, Yang J, Guedes A, Morisseau C, Garcia R, Knych H, Tearney C, Hamamoto B, Hwang SH, Wagner K, Hammock BD. PMID: 34443621; PMCID: PMC8399023.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    43. Inhibition of sEH via stabilizing the level of EETs alleviated Alzheimer's disease through GSK3β signaling pathway. Food Chem Toxicol. 2021 Oct; 156:112516. Sun CP, Zhang XY, Zhou JJ, Huo XK, Yu ZL, Morisseau C, Hammock BD, Ma XC. PMID: 34411643; PMCID: PMC8889936.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    44. EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence. Elife. 2021 08 03; 10. Gautheron J, Morisseau C, Chung WK, Zammouri J, Auclair M, Baujat G, Capel E, Moulin C, Wang Y, Yang J, Hammock BD, Cerame B, Phan F, Fève B, Vigouroux C, Andreelli F, Jeru I. PMID: 34342583; PMCID: PMC8331186.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    45. Differential Effects of 17,18-EEQ and 19,20-EDP Combined with Soluble Epoxide Hydrolase Inhibitor t-TUCB on Diet-Induced Obesity in Mice. Int J Mol Sci. 2021 Jul 31; 22(15). Yang Y, Xu X, Wu H, Yang J, Chen J, Morisseau C, Hammock BD, Bettaieb A, Zhao L. PMID: 34361032; PMCID: PMC8347952.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    46. Role of Epoxide Hydrolases and Cytochrome P450s on Metabolism of KZR-616, a First-in-Class Selective Inhibitor of the Immunoproteasome. Drug Metab Dispos. 2021 09; 49(9):810-821. Fang Y, Johnson H, Anderl JL, Muchamuel T, McMinn D, Morisseau C, Hammock BD, Kirk C, Wang J. PMID: 34234005.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    47. Discovery of memantyl urea derivatives as potent soluble epoxide hydrolase inhibitors against lipopolysaccharide-induced sepsis. Eur J Med Chem. 2021 Nov 05; 223:113678. Du F, Sun W, Morisseau C, Hammock BD, Bao X, Liu Q, Wang C, Zhang T, Yang H, Zhou J, Xiao W, Liu Z, Chen G. PMID: 34218083; PMCID: PMC8877601.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    48. Molecular docking-guided synthesis of NSAID-glucosamine bioconjugates and their evaluation as COX-1/COX-2 inhibitors with potentially reduced gastric toxicity. Chem Biol Drug Des. 2021 07; 98(1):102-113. Jones Lipinski RA, Thillier Y, Morisseau C, Sebastiano CS, Smith BC, Hall CD, Katritzky AR. PMID: 33955172; PMCID: PMC8281356.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    49. Genetic deficiency or pharmacological inhibition of soluble epoxide hydrolase ameliorates high fat diet-induced pancreatic β-cell dysfunction and loss. Free Radic Biol Med. 2021 08 20; 172:48-57. Koike S, Hsu MF, Bettaieb A, Chu B, Matsumoto N, Morisseau C, Havel PJ, Huising MO, Hammock BD, Haj FG. PMID: 34038767; PMCID: PMC9901526.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    50. Activity of sEH and Oxidant Status during Systemic Bovine Coliform Mastitis. Antioxidants (Basel). 2021 May 20; 10(5). Mavangira V, Kuhn MJ, Abuelo A, Morisseau C, Hammock BD, Sordillo LM. PMID: 34065244; PMCID: PMC8161397.
      View in: PubMed   Mentions: 2  
    51. Relative Importance of Soluble and Microsomal Epoxide Hydrolases for the Hydrolysis of Epoxy-Fatty Acids in Human Tissues. Int J Mol Sci. 2021 May 08; 22(9). Morisseau C, Kodani SD, Kamita SG, Yang J, Lee KSS, Hammock BD. PMID: 34066758; PMCID: PMC8125816.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    52. From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis. J Med Chem. 2021 05 13; 64(9):5429-5446. Codony S, Calvó-Tusell C, Valverde E, Osuna S, Morisseau C, Loza MI, Brea J, Pérez C, Rodríguez-Franco MI, Pizarro-Delgado J, Corpas R, Griñán-Ferré C, Pallàs M, Sanfeliu C, Vázquez-Carrera M, Hammock BD, Feixas F, Vázquez S. PMID: 33945278; PMCID: PMC8634379.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    53. Ibuprofen alters epoxide hydrolase activity and epoxy-oxylipin metabolites associated with different metabolic pathways in murine livers. Sci Rep. 2021 03 29; 11(1):7042. Tiwari S, Yang J, Morisseau C, Durbin-Johnson B, Hammock BD, Gomes AV. PMID: 33782432; PMCID: PMC8007717.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    54. Adrenic Acid-Derived Epoxy Fatty Acids Are Naturally Occurring Lipids and Their Methyl Ester Prodrug Reduces Endoplasmic Reticulum Stress and Inflammatory Pain. ACS Omega. 2021 Mar 16; 6(10):7165-7174. Singh N, Barnych B, Wagner KM, Wan D, Morisseau C, Hammock BD. PMID: 33748630; PMCID: PMC7970556.
      View in: PubMed   Mentions: 6  
    55. Preservation of epoxyeicosatrienoic acid bioavailability prevents renal allograft dysfunction and cardiovascular alterations in kidney transplant recipients. Sci Rep. 2021 02 12; 11(1):3739. Duflot T, Laurent C, Soudey A, Fonrose X, Hamzaoui M, Iacob M, Bertrand D, Favre J, Etienne I, Roche C, Coquerel D, Le Besnerais M, Louhichi S, Tarlet T, Li D, Brunel V, Morisseau C, Richard V, Joannidès R, Stanke-Labesque F, Lamoureux F, Guerrot D, Bellien J. PMID: 33580125; PMCID: PMC7881112.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    56. Adenosine A2A receptor and vascular response: role of soluble epoxide hydrolase, adenosine A1 receptor and angiotensin-II. Mol Cell Biochem. 2021 May; 476(5):1965-1978. Hanif A, Agba SO, Ledent C, Tilley SL, Morisseau C, Nayeem MA. PMID: 33511551.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    57. Inhibition of the Soluble Epoxide Hydrolase as an Analgesic Strategy: A Review of Preclinical Evidence. J Pain Res. 2021; 14:61-72. Wang Y, Wagner KM, Morisseau C, Hammock BD. PMID: 33488116; PMCID: PMC7814236.
      View in: PubMed   Mentions: 14  
    58. Discovery of Soluble Epoxide Hydrolase Inhibitors from Chemical Synthesis and Natural Products. J Med Chem. 2021 01 14; 64(1):184-215. Sun CP, Zhang XY, Morisseau C, Hwang SH, Zhang ZJ, Hammock BD, Ma XC. PMID: 33369424; PMCID: PMC7942193.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
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    120. Vascular Endothelial Over-Expression of Human Soluble Epoxide Hydrolase (Tie2-sEH Tr) Attenuates Coronary Reactive Hyperemia in Mice: Role of Oxylipins and ω-Hydroxylases. PLoS One. 2017; 12(1):e0169584. Hanif A, Edin ML, Zeldin DC, Morisseau C, Falck JR, Nayeem MA. PMID: 28056085; PMCID: PMC5215949.
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    121. Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators. Proc Natl Acad Sci U S A. 2017 01 03; 114(1):136-141. Flitter BA, Hvorecny KL, Ono E, Eddens T, Yang J, Kwak DH, Bahl CD, Hampton TH, Morisseau C, Hammock BD, Liu X, Lee JS, Kolls JK, Levy BD, Madden DR, Bomberger JM. PMID: 27980032; PMCID: PMC5224368.
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    122. Chemical synthesis and biological evaluation of ω-hydroxy polyunsaturated fatty acids. Bioorg Med Chem Lett. 2017 02 01; 27(3):620-625. Hwang SH, Wagner K, Xu J, Yang J, Li X, Cao Z, Morisseau C, Lee KS, Hammock BD. PMID: 28025003; PMCID: PMC5584617.
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    124. Screening of soluble epoxide hydrolase inhibitory ingredients from traditional Chinese medicines for anti-inflammatory use. J Ethnopharmacol. 2016 Dec 24; 194:475-482. Liu JY, Morisseau C, Huang H, Hammock BD. PMID: 27702689; PMCID: PMC5584568.
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    125. Parabens inhibit fatty acid amide hydrolase: A potential role in paraben-enhanced 3T3-L1 adipocyte differentiation. Toxicol Lett. 2016 Nov 16; 262:92-99. Kodani SD, Overby HB, Morisseau C, Chen J, Zhao L, Hammock BD. PMID: 27659731; PMCID: PMC5096949.
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    129. 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) Decreases Hepatic and Systemic Ratios of Epoxide to Diol Metabolites of Unsaturated Fatty Acids in Male Rats. Toxicol Sci. 2016 08; 152(2):309-22. Wu X, Yang J, Morisseau C, Robertson LW, Hammock B, Lehmler HJ. PMID: 27208083; PMCID: PMC4960907.
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    130. Computer-aided drug design guided by hydrogen/deuterium exchange mass spectrometry: A powerful combination for the development of potent and selective inhibitors of Group VIA calcium-independent phospholipase A2. Bioorg Med Chem. 2016 10 15; 24(20):4801-4811. Mouchlis VD, Morisseau C, Hammock BD, Li S, McCammon JA, Dennis EA. PMID: 27320659; PMCID: PMC5053890.
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    131. Rational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa. J Med Chem. 2016 05 26; 59(10):4790-9. Kitamura S, Hvorecny KL, Niu J, Hammock BD, Madden DR, Morisseau C. PMID: 27120257; PMCID: PMC4957648.
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    132. Anti-Ulcer Efficacy of Soluble Epoxide Hydrolase Inhibitor TPPU on Diclofenac-Induced Intestinal Ulcers. J Pharmacol Exp Ther. 2016 06; 357(3):529-36. Goswami SK, Wan D, Yang J, Trindade da Silva CA, Morisseau C, Kodani SD, Yang GY, Inceoglu B, Hammock BD. PMID: 26989141; PMCID: PMC4885505.
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    133. Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress. Proc Natl Acad Sci U S A. 2016 Mar 29; 113(13):E1944-52. Ren Q, Ma M, Ishima T, Morisseau C, Yang J, Wagner KM, Zhang JC, Yang C, Yao W, Dong C, Han M, Hammock BD, Hashimoto K. PMID: 26976569; PMCID: PMC4822604.
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    134. Visualizing the Mechanism of Epoxide Hydrolysis by the Bacterial Virulence Enzyme Cif. Biochemistry. 2016 Feb 09; 55(5):788-97. Bahl CD, Hvorecny KL, Morisseau C, Gerber SA, Madden DR. PMID: 26752215; PMCID: PMC4765904.
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    135. Effect of a Soluble Epoxide Hydrolase Inhibitor, UC1728, on LPS-Induced Uveitis in the Rabbit. J Ocul Biol. 2016 Jan; 4(1). McLellan GJ, Aktas Z, Hennes-Beean E, Kolb AW, Larsen IV, Schmitz EJ, Clausius HR, Yang J, Hwang SH, Morisseau C, Inceoglu B, Hammock BD, Brandt CR. PMID: 28066796; PMCID: PMC5218821.
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    137. Omeprazole increases the efficacy of a soluble epoxide hydrolase inhibitor in a PGE₂ induced pain model. Toxicol Appl Pharmacol. 2015 Dec 15; 289(3):419-27. Goswami SK, Inceoglu B, Yang J, Wan D, Kodani SD, da Silva CA, Morisseau C, Hammock BD. PMID: 26522832; PMCID: PMC4666679.
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    138. 1,3-Disubstituted and 1,3,3-trisubstituted adamantyl-ureas with isoxazole as soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett. 2015 Dec 01; 25(23):5514-9. Burmistrov V, Morisseau C, Danilov D, Harris TR, Dalinger I, Vatsadze I, Shkineva T, Butov GM, Hammock BD. PMID: 26520661; PMCID: PMC4654407.
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    139. In vitro and in vivo metabolism of N-adamantyl substituted urea-based soluble epoxide hydrolase inhibitors. Biochem Pharmacol. 2015 Dec 15; 98(4):718-31. Liu JY, Tsai HJ, Morisseau C, Lango J, Hwang SH, Watanabe T, Kim IH, Hammock BD. PMID: 26494425; PMCID: PMC4656071.
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    140. Aerobic exercise-based rehabilitation affects the activities of progenitor endothelial cells through EETs pathway. Med Hypotheses. 2015 Dec; 85(6):1037-8. Deng LM, Li XP, Xu DY, Morisseau C, Chiamvimonvat N, Hammock BD. PMID: 26454561; PMCID: PMC5003087.
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    141. Heavy chain single-domain antibodies to detect native human soluble epoxide hydrolase. Anal Bioanal Chem. 2015 Sep; 407(24):7275-83. Cui Y, Li D, Morisseau C, Dong JX, Yang J, Wan D, Rossotti MA, Gee SJ, González-Sapienza GG, Hammock BD. PMID: 26229025; PMCID: PMC4573264.
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    143. Oral treatment of rodents with soluble epoxide hydrolase inhibitor 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea (TPPU): Resulting drug levels and modulation of oxylipin pattern. Prostaglandins Other Lipid Mediat. 2015 Sep; 121(Pt A):131-7. Ostermann AI, Herbers J, Willenberg I, Chen R, Hwang SH, Greite R, Morisseau C, Gueler F, Hammock BD, Schebb NH. PMID: 26117215; PMCID: PMC4688279.
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    145. Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive. Pharmacol Res. 2015 Jul; 97:7-15. Sasso O, Wagner K, Morisseau C, Inceoglu B, Hammock BD, Piomelli D. PMID: 25882247; PMCID: PMC4464910.
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    146. High salt diet modulates vascular response in A2AAR (+/+) and A 2AAR (-/-) mice: role of sEH, PPARγ, and K ATP channels. Mol Cell Biochem. 2015 Jun; 404(1-2):87-96. Pradhan I, Ledent C, Mustafa SJ, Morisseau C, Nayeem MA. PMID: 25739357; PMCID: PMC4470368.
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    148. A Photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase. Chembiochem. 2015 Mar 23; 16(5):766-71. Nollmann FI, Heinrich AK, Brachmann AO, Morisseau C, Mukherjee K, Casanova-Torres ÁM, Strobl F, Kleinhans D, Kinski S, Schultz K, Beeton ML, Kaiser M, Chu YY, Phan Ke L, Thanwisai A, Bozhüyük KA, Chantratita N, Götz F, Waterfield NR, Vilcinskas A, Stelzer EH, Goodrich-Blair H, Hammock BD, Bode HB. PMID: 25711603; PMCID: PMC4486325.
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    151. Potent natural soluble epoxide hydrolase inhibitors from Pentadiplandra brazzeana baillon: synthesis, quantification, and measurement of biological activities in vitro and in vivo. PLoS One. 2015; 10(2):e0117438. Kitamura S, Morisseau C, Inceoglu B, Kamita SG, De Nicola GR, Nyegue M, Hammock BD. PMID: 25659109; PMCID: PMC4319826.
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    152. Distinct cellular sources of hepoxilin A3 and leukotriene B4 are used to coordinate bacterial-induced neutrophil transepithelial migration. J Immunol. 2015 Feb 01; 194(3):1304-15. Pazos MA, Pirzai W, Yonker LM, Morisseau C, Gronert K, Hurley BP. PMID: 25548217; PMCID: PMC4297725.
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    155. Biological evaluation of a novel sorafenib analogue, t-CUPM. Cancer Chemother Pharmacol. 2015 Jan; 75(1):161-71. Wecksler AT, Hwang SH, Liu JY, Wettersten HI, Morisseau C, Wu J, Weiss RH, Hammock BD. PMID: 25413440; PMCID: PMC4400119.
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    157. Aberrant soluble epoxide hydrolase and oxylipin levels in a porcine arteriovenous graft stenosis model. J Vasc Res. 2014; 51(4):269-82. Terry CM, Carlson ML, He Y, Ulu A, Morisseau C, Blumenthal DK, Hammock BD, Cheung AK. PMID: 25196102; PMCID: PMC4235611.
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    158. Expression and characterization of an epoxide hydrolase from Anopheles gambiae with high activity on epoxy fatty acids. Insect Biochem Mol Biol. 2014 Nov; 54:42-52. Xu J, Morisseau C, Hammock BD. PMID: 25173592; PMCID: PMC4252830.
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    160. Potent, orally available, selective COX-2 inhibitors based on 2-imidazoline core. Eur J Med Chem. 2014 Sep 12; 84:160-72. Sarnpitak P, Mujumdar P, Morisseau C, Hwang SH, Hammock B, Iurchenko V, Zozulya S, Gavalas A, Geronikaki A, Ivanenkov Y, Krasavin M. PMID: 25016374.
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    161. Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):8167-72. Charles RL, Rudyk O, Prysyazhna O, Kamynina A, Yang J, Morisseau C, Hammock BD, Freeman BA, Eaton P. PMID: 24843165; PMCID: PMC4050620.
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    162. Effect of soluble epoxide hydrolase polymorphism on substrate and inhibitor selectivity and dimer formation. J Lipid Res. 2014 06; 55(6):1131-8. Morisseau C, Wecksler AT, Deng C, Dong H, Yang J, Lee KS, Kodani SD, Hammock BD. PMID: 24771868; PMCID: PMC4031944.
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    164. Synthesis and functional survey of new Tacrine analogs modified with nitroxides or their precursors. Eur J Med Chem. 2014 Apr 22; 77:343-50. Kálai T, Altman R, Maezawa I, Balog M, Morisseau C, Petrlova J, Hammock BD, Jin LW, Trudell JR, Voss JC, Hideg K. PMID: 24657571; PMCID: PMC4065883.
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    166. Explorations of substituted urea functionality for the discovery of new activators of the heme-regulated inhibitor kinase. J Med Chem. 2013 Dec 12; 56(23):9457-70. Chen T, Takrouri K, Hee-Hwang S, Rana S, Yefidoff-Freedman R, Halperin J, Natarajan A, Morisseau C, Hammock B, Chorev M, Aktas BH. PMID: 24261904; PMCID: PMC3938169.
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    167. Anti-inflammatory effects of ω-3 polyunsaturated fatty acids and soluble epoxide hydrolase inhibitors in angiotensin-II-dependent hypertension. J Cardiovasc Pharmacol. 2013 Sep; 62(3):285-97. Ulu A, Harris TR, Morisseau C, Miyabe C, Inoue H, Schuster G, Dong H, Iosif AM, Liu JY, Weiss RH, Chiamvimonvat N, Imig JD, Hammock BD. PMID: 23676336; PMCID: PMC3773051.
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    168. Characterization of Hovi-mEH1, a microsomal epoxide hydrolase from the glassy-winged sharpshooter Homalodisca vitripennis. Arch Insect Biochem Physiol. 2013 Aug; 83(4):171-9. Kamita SG, Oshita GH, Wang P, Morisseau C, Hammock BD, Nandety RS, Falk BW. PMID: 23704009; PMCID: PMC3846607.
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    172. Use of a soluble epoxide hydrolase inhibitor as an adjunctive analgesic in a horse with laminitis. Vet Anaesth Analg. 2013 Jul; 40(4):440-8. Guedes AG, Morisseau C, Sole A, Soares JH, Ulu A, Dong H, Hammock BD. PMID: 23463912; PMCID: PMC3956586.
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    173. Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3-heteroaryl ureas with improved in vitro pharmacokinetic properties. Bioorg Med Chem. 2013 May 01; 21(9):2587-99. North EJ, Scherman MS, Bruhn DF, Scarborough JS, Maddox MM, Jones V, Grzegorzewicz A, Yang L, Hess T, Morisseau C, Jackson M, McNeil MR, Lee RE. PMID: 23498915; PMCID: PMC3780361.
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    175. Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties. Nat Commun. 2013; 4:1840. de Medina P, Paillasse MR, Segala G, Voisin M, Mhamdi L, Dalenc F, Lacroix-Triki M, Filleron T, Pont F, Saati TA, Morisseau C, Hammock BD, Silvente-Poirot S, Poirot M. PMID: 23673625; PMCID: PMC3674249.
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    177. Cloning and characterization of a microsomal epoxide hydrolase from Heliothis virescens. Insect Biochem Mol Biol. 2013 Mar; 43(3):219-28. Kamita SG, Yamamoto K, Dadala MM, Pha K, Morisseau C, Escaich A, Hammock BD. PMID: 23276675; PMCID: PMC3577957.
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    178. Beneficial effects of inhibition of soluble epoxide hydrolase on glucose homeostasis and islet damage in a streptozotocin-induced diabetic mouse model. Prostaglandins Other Lipid Mediat. 2013 Jul-Aug; 104-105:42-8. Chen L, Fan C, Zhang Y, Bakri M, Dong H, Morisseau C, Maddipati KR, Luo P, Wang CY, Hammock BD, Wang MH. PMID: 23247129; PMCID: PMC4052893.
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    179. Förster resonance energy transfer competitive displacement assay for human soluble epoxide hydrolase. Anal Biochem. 2013 Mar 15; 434(2):259-68. Lee KS, Morisseau C, Yang J, Wang P, Hwang SH, Hammock BD. PMID: 23219719; PMCID: PMC3632402.
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    181. Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett. 2013 Jan 15; 23(2):417-21. Pecic S, Pakhomova S, Newcomer ME, Morisseau C, Hammock BD, Zhu Z, Rinderspacher A, Deng SX. PMID: 23237835; PMCID: PMC3541548.
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    182. Adenosine A2A receptor modulates vascular response in soluble epoxide hydrolase-null mice through CYP-epoxygenases and PPARγ. Am J Physiol Regul Integr Comp Physiol. 2013 Jan 01; 304(1):R23-32. Nayeem MA, Pradhan I, Mustafa SJ, Morisseau C, Falck JR, Zeldin DC. PMID: 23152114; PMCID: PMC3543649.
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    183. Development of On-line Liquid Chromatography-Biochemical Detection for Soluble Epoxide Hydrolase Inhibitors in Mixtures. Chromatographia. 2013 Jan 01; 76(1-2):13-21. Falck D, Schebb NH, Prihatiningtyas S, Zhang J, Heus F, Morisseau C, Kool J, Hammock BD, Niessen WM. PMID: 23526703; PMCID: PMC3601784.
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    184. Hepoxilin A(3) facilitates neutrophilic breach of lipoxygenase-expressing airway epithelial barriers. J Immunol. 2012 Nov 15; 189(10):4960-9. Tamang DL, Pirzai W, Priebe GP, Traficante DC, Pier GB, Falck JR, Morisseau C, Hammock BD, McCormick BA, Gronert K, Hurley BP. PMID: 23045615; PMCID: PMC3490410.
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    185. Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health. Annu Rev Pharmacol Toxicol. 2013; 53:37-58. Morisseau C, Hammock BD. PMID: 23020295; PMCID: PMC3578707.
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    186. Biologically active ester derivatives as potent inhibitors of the soluble epoxide hydrolase. Bioorg Med Chem Lett. 2012 Sep 15; 22(18):5889-92. Kim IH, Nishi K, Kasagami T, Morisseau C, Liu JY, Tsai HJ, Hammock BD. PMID: 22901393; PMCID: PMC3432147.
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    187. EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides. J Lipid Res. 2012 Oct; 53(10):2038-2045. Decker M, Adamska M, Cronin A, Di Giallonardo F, Burgener J, Marowsky A, Falck JR, Morisseau C, Hammock BD, Gruzdev A, Zeldin DC, Arand M. PMID: 22798687; PMCID: PMC3435537.
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    188. Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of type I diabetes. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11390-5. Inceoglu B, Wagner KM, Yang J, Bettaieb A, Schebb NH, Hwang SH, Morisseau C, Haj FG, Hammock BD. PMID: 22733772; PMCID: PMC3396532.
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    189. Role of epoxide hydrolases in lipid metabolism. Biochimie. 2013 Jan; 95(1):91-5. Morisseau C. PMID: 22722082; PMCID: PMC3495083.
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    190. Soluble epoxide hydrolase expression in a porcine model of arteriovenous graft stenosis and anti-inflammatory effects of a soluble epoxide hydrolase inhibitor. Am J Physiol Cell Physiol. 2012 Aug 01; 303(3):C278-90. Sanders WG, Morisseau C, Hammock BD, Cheung AK, Terry CM. PMID: 22621785; PMCID: PMC3423029.
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    191. A potent soluble epoxide hydrolase inhibitor, t-AUCB, acts through PPARγ to modulate the function of endothelial progenitor cells from patients with acute myocardial infarction. Int J Cardiol. 2013 Aug 20; 167(4):1298-304. Xu DY, Davis BB, Wang ZH, Zhao SP, Wasti B, Liu ZL, Li N, Morisseau C, Chiamvimonvat N, Hammock BD. PMID: 22525341; PMCID: PMC3821736.
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    192. Screening a library of 1600 adamantyl ureas for anti-Mycobacterium tuberculosis activity in vitro and for better physical chemical properties for bioavailability. Bioorg Med Chem. 2012 May 15; 20(10):3255-62. Scherman MS, North EJ, Jones V, Hess TN, Grzegorzewicz AE, Kasagami T, Kim IH, Merzlikin O, Lenaerts AJ, Lee RE, Jackson M, Morisseau C, McNeil MR. PMID: 22522007; PMCID: PMC3345085.
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    193. Structure-based optimization of the piperazino-containing 1,3-disubstituted ureas affording sub-nanomolar inhibitors of soluble epoxide hydrolase. Medchemcomm. 2012 Mar 01; (3):379-384. Huang SX, Cao B, Morisseau C, Jin Y, Hammock BD, Long YQ. PMID: 25225606; PMCID: PMC4163146.
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    194. Role of soluble epoxide hydrolase phosphatase activity in the metabolism of lysophosphatidic acids. Biochem Biophys Res Commun. 2012 Mar 23; 419(4):796-800. Morisseau C, Schebb NH, Dong H, Ulu A, Aronov PA, Hammock BD. PMID: 22387545; PMCID: PMC3313618.
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    195. Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nat Chem Biol. 2012 Feb 19; 8(4):334-41. Grzegorzewicz AE, Pham H, Gundi VA, Scherman MS, North EJ, Hess T, Jones V, Gruppo V, Born SE, Korduláková J, Chavadi SS, Morisseau C, Lenaerts AJ, Lee RE, McNeil MR, Jackson M. PMID: 22344175; PMCID: PMC3307863.
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    196. Development of monoclonal antibodies to human microsomal epoxide hydrolase and analysis of "preneoplastic antigen"-like molecules. Toxicol Appl Pharmacol. 2012 Apr 01; 260(1):17-26. Duan H, Yoshimura K, Kobayashi N, Sugiyama K, Sawada J, Saito Y, Morisseau C, Hammock BD, Akatsuka T. PMID: 22310175; PMCID: PMC3319115.
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    197. Monoclonal antibodies reveal multiple forms of expression of human microsomal epoxide hydrolase. Toxicol Appl Pharmacol. 2012 Apr 01; 260(1):27-34. Duan H, Takagi A, Kayano H, Koyama I, Morisseau C, Hammock BD, Akatsuka T. PMID: 22306621; PMCID: PMC3319120.
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    198. Corncob bedding alters the effects of estrogens on aggressive behavior and reduces estrogen receptor-α expression in the brain. Endocrinology. 2012 Feb; 153(2):949-53. Villalon Landeros R, Morisseau C, Yoo HJ, Fu SH, Hammock BD, Trainor BC. PMID: 22186416; PMCID: PMC3275391.
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    199. N-terminal domain of soluble epoxide hydrolase negatively regulates the VEGF-mediated activation of endothelial nitric oxide synthase. Cardiovasc Res. 2012 Jan 01; 93(1):120-9. Hou HH, Hammock BD, Su KH, Morisseau C, Kou YR, Imaoka S, Oguro A, Shyue SK, Zhao JF, Lee TS. PMID: 22072631; PMCID: PMC3243038.
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    200. Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett. 2012 Jan 01; 22(1):601-5. Pecic S, Deng SX, Morisseau C, Hammock BD, Landry DW. PMID: 22079754; PMCID: PMC3337727.
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    201. Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats. Exp Diabetes Res. 2012; 2012:758614. Iyer A, Kauter K, Alam MA, Hwang SH, Morisseau C, Hammock BD, Brown L. PMID: 22007192; PMCID: PMC3191770.
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    202. The structure-activity relationship of urea derivatives as anti-tuberculosis agents. Bioorg Med Chem. 2011 Sep 15; 19(18):5585-95. Brown JR, North EJ, Hurdle JG, Morisseau C, Scarborough JS, Sun D, Korduláková J, Scherman MS, Jones V, Grzegorzewicz A, Crew RM, Jackson M, McNeil MR, Lee RE. PMID: 21840723; PMCID: PMC3176295.
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    203. Inhibition of soluble epoxide hydrolase contributes to the anti-inflammatory effect of antimicrobial triclocarban in a murine model. Toxicol Appl Pharmacol. 2011 Sep 01; 255(2):200-6. Liu JY, Qiu H, Morisseau C, Hwang SH, Tsai HJ, Ulu A, Chiamvimonvat N, Hammock BD. PMID: 21741984; PMCID: PMC3156297.
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    204. Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors. Anal Bioanal Chem. 2011 May; 400(5):1359-66. Schebb NH, Huby M, Morisseau C, Hwang SH, Hammock BD. PMID: 21479549; PMCID: PMC3081056.
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    205. Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase. J Med Chem. 2011 Apr 28; 54(8):3037-50. Hwang SH, Wagner KM, Morisseau C, Liu JY, Dong H, Wecksler AT, Hammock BD. PMID: 21434686; PMCID: PMC3281519.
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    206. Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in a rat liver cell line. Toxicol Appl Pharmacol. 2011 May 15; 253(1):45-56. Barhoumi R, Mouneimne Y, Ramos E, Morisseau C, Hammock BD, Safe S, Parrish AR, Burghardt RC. PMID: 21420996; PMCID: PMC3081912.
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    207. Investigation of human exposure to triclocarban after showering and preliminary evaluation of its biological effects. Environ Sci Technol. 2011 Apr 01; 45(7):3109-15. Schebb NH, Inceoglu B, Ahn KC, Morisseau C, Gee SJ, Hammock BD. PMID: 21381656; PMCID: PMC3470465.
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    208. Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP. Proc Natl Acad Sci U S A. 2011 Mar 22; 108(12):5093-7. Inceoglu B, Wagner K, Schebb NH, Morisseau C, Jinks SL, Ulu A, Hegedus C, Rose T, Brosnan R, Hammock BD. PMID: 21383170; PMCID: PMC3064364.
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    209. Development of fluorescent substrates for microsomal epoxide hydrolase and application to inhibition studies. Anal Biochem. 2011 Jul 01; 414(1):154-62. Morisseau C, Bernay M, Escaich A, Sanborn JR, Lango J, Hammock BD. PMID: 21371418; PMCID: PMC3090455.
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    210. Soluble epoxide hydrolase in the generation and maintenance of high blood pressure in spontaneously hypertensive rats. Am J Physiol Endocrinol Metab. 2011 Apr; 300(4):E691-8. Koeners MP, Wesseling S, Ulu A, Sepúlveda RL, Morisseau C, Braam B, Hammock BD, Joles JA. PMID: 21266668; PMCID: PMC3074945.
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    211. Redox regulation of soluble epoxide hydrolase by 15-deoxy-delta-prostaglandin J2 controls coronary hypoxic vasodilation. Circ Res. 2011 Feb 04; 108(3):324-34. Charles RL, Burgoyne JR, Mayr M, Weldon SM, Hubner N, Dong H, Morisseau C, Hammock BD, Landar A, Eaton P. PMID: 21164107; PMCID: PMC3259859.
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    212. Incorporation of piperazino functionality into 1,3-disubstituted urea as the tertiary pharmacophore affording potent inhibitors of soluble epoxide hydrolase with improved pharmacokinetic properties. J Med Chem. 2010 Dec 09; 53(23):8376-86. Huang SX, Li HY, Liu JY, Morisseau C, Hammock BD, Long YQ. PMID: 21070033; PMCID: PMC3070159.
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    213. 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain. J Med Chem. 2010 Oct 14; 53(19):7067-75. Rose TE, Morisseau C, Liu JY, Inceoglu B, Jones PD, Sanborn JR, Hammock BD. PMID: 20812725; PMCID: PMC3285450.
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    214. Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease. PLoS One. 2010 Aug 04; 5(8):e11979. Jung O, Jansen F, Mieth A, Barbosa-Sicard E, Pliquett RU, Babelova A, Morisseau C, Hwang SH, Tsai C, Hammock BD, Schaefer L, Geisslinger G, Amann K, Brandes RP. PMID: 20694143; PMCID: PMC2915917.
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    215. Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids. J Lipid Res. 2010 Dec; 51(12):3481-90. Morisseau C, Inceoglu B, Schmelzer K, Tsai HJ, Jinks SL, Hegedus CM, Hammock BD. PMID: 20664072; PMCID: PMC2975720.
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    216. Function of phenylalanine 259 and threonine 314 within the substrate binding pocket of the juvenile hormone esterase of Manduca sexta. Biochemistry. 2010 May 04; 49(17):3733-42. Kamita SG, Wogulis MD, Law CS, Morisseau C, Tanaka H, Huang H, Wilson DK, Hammock BD. PMID: 20307057; PMCID: PMC3570046.
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    217. Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis. J Pharmacol Exp Ther. 2010 Aug; 334(2):430-8. Luo P, Chang HH, Zhou Y, Zhang S, Hwang SH, Morisseau C, Wang CY, Inscho EW, Hammock BD, Wang MH. PMID: 20439437; PMCID: PMC2913776.
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    218. Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase. Am J Physiol Regul Integr Comp Physiol. 2010 Jul; 299(1):R325-33. Nayeem MA, Zeldin DC, Boegehold MA, Morisseau C, Marowsky A, Ponnoth DS, Roush KP, Falck JR. PMID: 20427718; PMCID: PMC2904154.
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    219. Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs. Eur J Pharm Sci. 2010 Jun 14; 40(3):222-38. Tsai HJ, Hwang SH, Morisseau C, Yang J, Jones PD, Kasagami T, Kim IH, Hammock BD. PMID: 20359531; PMCID: PMC3285443.
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    220. Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice. Arterioscler Thromb Vasc Biol. 2010 May; 30(5):909-14. Revermann M, Schloss M, Barbosa-Sicard E, Mieth A, Liebner S, Morisseau C, Geisslinger G, Schermuly RT, Fleming I, Hammock BD, Brandes RP. PMID: 20224052; PMCID: PMC2919323.
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    221. Impact of epoxyeicosatrienoic acids in lung ischemia-reperfusion injury. Microcirculation. 2010 Feb; 17(2):137-46. Townsley MI, Morisseau C, Hammock B, King JA. PMID: 20163540; PMCID: PMC2923642.
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    222. Crystal structure of the cystic fibrosis transmembrane conductance regulator inhibitory factor Cif reveals novel active-site features of an epoxide hydrolase virulence factor. J Bacteriol. 2010 Apr; 192(7):1785-95. Bahl CD, Morisseau C, Bomberger JM, Stanton BA, Hammock BD, O'Toole GA, Madden DR. PMID: 20118260; PMCID: PMC2838060.
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    223. Tryptophan fluorescence quenching by enzyme inhibitors as a tool for enzyme active site structure investigation: epoxide hydrolase. Curr Pharm Biotechnol. 2009 Sep; 10(6):589-99. Matveeva EG, Morisseau C, Goodrow MH, Mullin C, Hammock BD. PMID: 19619123; PMCID: PMC2861369.
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    224. 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition. J Med Chem. 2009 Aug 27; 52(16):5069-75. Falck JR, Kodela R, Manne R, Atcha KR, Puli N, Dubasi N, Manthati VL, Capdevila JH, Yi XY, Goldman DH, Morisseau C, Hammock BD, Campbell WB. PMID: 19653681; PMCID: PMC2888647.
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    225. Inhibition of the soluble epoxide hydrolase by tyrosine nitration. J Biol Chem. 2009 Oct 09; 284(41):28156-28163. Barbosa-Sicard E, Frömel T, Keserü B, Brandes RP, Morisseau C, Hammock BD, Braun T, Krüger M, Fleming I. PMID: 19704161; PMCID: PMC2788866.
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    226. Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo. Mol Cancer Ther. 2009 Aug; 8(8):2193-203. Liu JY, Park SH, Morisseau C, Hwang SH, Hammock BD, Weiss RH. PMID: 19671760; PMCID: PMC2728155.
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    227. Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key enzymes and receptors. Environ Health Perspect. 2009 Dec; 117(12):1867-72. Morisseau C, Merzlikin O, Lin A, He G, Feng W, Padilla I, Denison MS, Pessah IN, Hammock BD. PMID: 20049205; PMCID: PMC2799460.
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    228. Expression and regulation of soluble epoxide hydrolase in adipose tissue. Obesity (Silver Spring). 2010 Mar; 18(3):489-98. De Taeye BM, Morisseau C, Coyle J, Covington JW, Luria A, Yang J, Murphy SB, Friedman DB, Hammock BB, Vaughan DE. PMID: 19644452; PMCID: PMC2864128.
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    229. Alteration in plasma testosterone levels in male mice lacking soluble epoxide hydrolase. Am J Physiol Endocrinol Metab. 2009 Aug; 297(2):E375-83. Luria A, Morisseau C, Tsai HJ, Yang J, Inceoglu B, De Taeye B, Watkins SM, Wiest MM, German JB, Hammock BD. PMID: 19458064; PMCID: PMC2724109.
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    230. Novel and highly sensitive fluorescent assay for leucine aminopeptidases. Anal Biochem. 2009 Aug 01; 391(1):11-6. Huang H, Tanaka H, Hammock BD, Morisseau C. PMID: 19433052; PMCID: PMC2748848.
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    231. Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats. J Hypertens. 2009 Feb; 27(2):322-31. Revermann M, Barbosa-Sicard E, Dony E, Schermuly RT, Morisseau C, Geisslinger G, Fleming I, Hammock BD, Brandes RP. PMID: 19226702; PMCID: PMC2863009.
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    232. Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities. Bioorg Med Chem Lett. 2009 Mar 15; 19(6):1784-9. Kasagami T, Kim IH, Tsai HJ, Nishi K, Hammock BD, Morisseau C. PMID: 19216074; PMCID: PMC2900318.
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    233. Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation. Br J Pharmacol. 2009 Jan; 156(2):284-96. Liu JY, Tsai HJ, Hwang SH, Jones PD, Morisseau C, Hammock BD. PMID: 19154430; PMCID: PMC2697843.
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    234. Differential subcellular distribution and colocalization of the microsomal and soluble epoxide hydrolases in cultured neonatal rat brain cortical astrocytes. J Neurosci Res. 2009 Jan; 87(1):218-27. Rawal S, Morisseau C, Hammock BD, Shivachar AC. PMID: 18711743; PMCID: PMC3592782.
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    235. Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways. Proc Natl Acad Sci U S A. 2008 Dec 02; 105(48):18901-6. Inceoglu B, Jinks SL, Ulu A, Hegedus CM, Georgi K, Schmelzer KR, Wagner K, Jones PD, Morisseau C, Hammock BD. PMID: 19028872; PMCID: PMC2596245.
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    236. Soluble epoxide hydrolase inhibitors reduce the development of atherosclerosis in apolipoprotein e-knockout mouse model. J Cardiovasc Pharmacol. 2008 Oct; 52(4):314-23. Ulu A, Davis BB, Tsai HJ, Kim IH, Morisseau C, Inceoglu B, Fiehn O, Hammock BD, Weiss RH. PMID: 18791465; PMCID: PMC2637359.
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    237. Inhibition of soluble epoxide hydrolase does not protect against endotoxin-mediated hepatic inflammation. J Pharmacol Exp Ther. 2008 Dec; 327(3):707-15. Fife KL, Liu Y, Schmelzer KR, Tsai HJ, Kim IH, Morisseau C, Hammock BD, Kroetz DL. PMID: 18815352; PMCID: PMC2761654.
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    238. Discovery of potent non-urea inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett. 2009 Apr 15; 19(8):2354-9. Xie Y, Liu Y, Gong G, Smith DH, Yan F, Rinderspacher A, Feng Y, Zhu Z, Li X, Deng SX, Branden L, Vidovic D, Chung C, Schürer S, Morisseau C, Hammock BD, Landry DW. PMID: 19303288; PMCID: PMC2738751.
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    239. The molecular structure of epoxide hydrolase B from Mycobacterium tuberculosis and its complex with a urea-based inhibitor. J Mol Biol. 2008 Sep 12; 381(4):897-912. Biswal BK, Morisseau C, Garen G, Cherney MM, Garen C, Niu C, Hammock BD, James MN. PMID: 18585390; PMCID: PMC2866126.
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    240. Gerry Brooks and epoxide hydrolases: four decades to a pharmaceutical. Pest Manag Sci. 2008 Jun; 64(6):594-609. Morisseau C, Hammock BD. PMID: 18383502.
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    241. Hydrolysis of cis- and trans-epoxyeicosatrienoic acids by rat red blood cells. J Pharmacol Exp Ther. 2008 Jul; 326(1):330-7. Jiang H, Zhu AG, Mamczur M, Morisseau C, Hammock BD, Falck JR, McGiff JC. PMID: 18445784; PMCID: PMC2732189.
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    242. Attenuation of cisplatin nephrotoxicity by inhibition of soluble epoxide hydrolase. Cell Biol Toxicol. 2009 Jun; 25(3):217-25. Parrish AR, Chen G, Burghardt RC, Watanabe T, Morisseau C, Hammock BD. PMID: 18386137; PMCID: PMC3033346.
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    243. Development of metabolically stable inhibitors of Mammalian microsomal epoxide hydrolase. Chem Res Toxicol. 2008 Apr; 21(4):951-7. Morisseau C, Newman JW, Wheelock CE, Hill Iii T, Morin D, Buckpitt AR, Hammock BD. PMID: 18363382.
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    244. Transcriptional regulation of the human soluble epoxide hydrolase gene EPHX2. Biochim Biophys Acta. 2008 Jan; 1779(1):17-27. Tanaka H, Kamita SG, Wolf NM, Harris TR, Wu Z, Morisseau C, Hammock BD. PMID: 18078836; PMCID: PMC2699939.
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    245. 1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic properties. J Med Chem. 2007 Oct 18; 50(21):5217-26. Kim IH, Tsai HJ, Nishi K, Kasagami T, Morisseau C, Hammock BD. PMID: 17894481; PMCID: PMC2543935.
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    246. Epoxyeicosatrienoic acids regulate Trp channel dependent Ca2+ signaling and hyperpolarization in endothelial cells. Arterioscler Thromb Vasc Biol. 2007 Dec; 27(12):2612-8. Fleming I, Rueben A, Popp R, Fisslthaler B, Schrodt S, Sander A, Haendeler J, Falck JR, Morisseau C, Hammock BD, Busse R. PMID: 17872452.
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    247. Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem. 2007 Aug 09; 50(16):3825-40. Hwang SH, Tsai HJ, Liu JY, Morisseau C, Hammock BD. PMID: 17616115; PMCID: PMC2596069.
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    248. Soluble epoxide hydrolase: a novel therapeutic target in stroke. J Cereb Blood Flow Metab. 2007 Dec; 27(12):1931-40. Zhang W, Koerner IP, Noppens R, Grafe M, Tsai HJ, Morisseau C, Luria A, Hammock BD, Falck JR, Alkayed NJ. PMID: 17440491; PMCID: PMC2664093.
      View in: PubMed   Mentions: 119     Fields:    Translation:Animals
    249. Increasing or stabilizing renal epoxyeicosatrienoic acid production attenuates abnormal renal function and hypertension in obese rats. Am J Physiol Renal Physiol. 2007 Jul; 293(1):F342-9. Huang H, Morisseau C, Wang J, Yang T, Falck JR, Hammock BD, Wang MH. PMID: 17442729.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
    250. Autoantibody response to microsomal epoxide hydrolase in hepatitis C and A. J Autoimmun. 2007 Feb; 28(1):7-18. Akatsuka T, Kobayashi N, Ishikawa T, Saito T, Shindo M, Yamauchi M, Kurokohchi K, Miyazawa H, Duan H, Matsunaga T, Komoda T, Morisseau C, Hammock BD. PMID: 17296285; PMCID: PMC1892246.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    251. Effect of ionic liquids on epoxide hydrolase-catalyzed synthesis of chiral 1,2-diols. Green Chem. 2007; 2007(9):162-168. Chiappe C, Leandri E, Hammock BD, Morisseau C. PMID: 18160974; PMCID: PMC2153531.
      View in: PubMed   Mentions: 3  
    252. Prevention of hypertension in DOCA-salt rats by an inhibitor of soluble epoxide hydrolase. Cell Biochem Biophys. 2007; 47(1):87-98. Loch D, Hoey A, Morisseau C, Hammock BO, Brown L. PMID: 17406062; PMCID: PMC1892223.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    253. Measurement of soluble epoxide hydrolase (sEH) activity. Curr Protoc Toxicol. 2007; Chapter 4:Unit 4.23. Morisseau C, Hammock BD. PMID: 23045145.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    254. Compensatory mechanism for homeostatic blood pressure regulation in Ephx2 gene-disrupted mice. J Biol Chem. 2007 Feb 02; 282(5):2891-8. Luria A, Weldon SM, Kabcenell AK, Ingraham RH, Matera D, Jiang H, Gill R, Morisseau C, Newman JW, Hammock BD. PMID: 17135253; PMCID: PMC2040337.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimals
    255. Peptidyl-urea based inhibitors of soluble epoxide hydrolases. Bioorg Med Chem Lett. 2006 Oct 15; 16(20):5439-44. Morisseau C, Newman JW, Tsai HJ, Baecker PA, Hammock BD. PMID: 16908134; PMCID: PMC1892215.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    256. Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase. Bioorg Med Chem. 2007 Jan 01; 15(1):312-23. Kim IH, Nishi K, Tsai HJ, Bradford T, Koda Y, Watanabe T, Morisseau C, Blanchfield J, Toth I, Hammock BD. PMID: 17046265; PMCID: PMC2040326.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    257. Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett. 2006 Nov 15; 16(22):5773-7. Hwang SH, Morisseau C, Do Z, Hammock BD. PMID: 16949285; PMCID: PMC1904340.
      View in: PubMed   Mentions: 17     Fields:    
    258. Inhibition of smooth muscle proliferation by urea-based alkanoic acids via peroxisome proliferator-activated receptor alpha-dependent repression of cyclin D1. Arterioscler Thromb Vasc Biol. 2006 Nov; 26(11):2462-8. Ng VY, Morisseau C, Falck JR, Hammock BD, Kroetz DL. PMID: 16917105; PMCID: PMC1904341.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    259. Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett. 2006 Oct 01; 16(19):5212-6. Jones PD, Tsai HJ, Do ZN, Morisseau C, Hammock BD. PMID: 16870439; PMCID: PMC1904344.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    260. Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs). Prostaglandins Other Lipid Mediat. 2007 Jan; 82(1-4):42-9. Inceoglu B, Schmelzer KR, Morisseau C, Jinks SL, Hammock BD. PMID: 17164131; PMCID: PMC1904338.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansCells
    261. The 5-substituted piperazine as a novel secondary pharmacophore greatly improving the physical properties of urea-based inhibitors of soluble epoxide hydrolase. Bioorg Med Chem. 2006 Oct 01; 14(19):6586-92. Li HY, Jin Y, Morisseau C, Hammock BD, Long YQ. PMID: 16784862; PMCID: PMC2040075.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    262. Substituted adamantyl-urea inhibitors of the soluble epoxide hydrolase dilate mesenteric resistance vessels. J Pharmacol Exp Ther. 2006 Sep; 318(3):1307-14. Olearczyk JJ, Field MB, Kim IH, Morisseau C, Hammock BD, Imig JD. PMID: 16772540.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    263. Development of a high-throughput screen for soluble epoxide hydrolase inhibition. Anal Biochem. 2006 Aug 01; 355(1):71-80. Wolf NM, Morisseau C, Jones PD, Hock B, Hammock BD. PMID: 16729954; PMCID: PMC1964503.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    264. High-throughput pharmacokinetic method: cassette dosing in mice associated with minuscule serial bleedings and LC/MS/MS analysis. Anal Chim Acta. 2006 Feb 10; 559(1):37-44. Watanabe T, Schulz D, Morisseau C, Hammock BD. PMID: 16636700; PMCID: PMC1447531.
      View in: PubMed   Mentions: 25     Fields:    
    265. Characterization of pyrethroid hydrolysis by the human liver carboxylesterases hCE-1 and hCE-2. Arch Biochem Biophys. 2006 Jan 01; 445(1):115-23. Nishi K, Huang H, Kamita SG, Kim IH, Morisseau C, Hammock BD. PMID: 16359636; PMCID: PMC1444892.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    266. Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids. Protein Sci. 2006 Jan; 15(1):58-64. Gomez GA, Morisseau C, Hammock BD, Christianson DW. PMID: 16322563; PMCID: PMC1762130.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    267. The antiinflammatory effect of laminar flow: the role of PPARgamma, epoxyeicosatrienoic acids, and soluble epoxide hydrolase. Proc Natl Acad Sci U S A. 2005 Nov 15; 102(46):16747-52. Liu Y, Zhang Y, Schmelzer K, Lee TS, Fang X, Zhu Y, Spector AA, Gill S, Morisseau C, Hammock BD, Shyy JY. PMID: 16267130; PMCID: PMC1276614.
      View in: PubMed   Mentions: 140     Fields:    Translation:AnimalsCells
    268. Attenuation of vascular smooth muscle cell proliferation by 1-cyclohexyl-3-dodecyl urea is independent of soluble epoxide hydrolase inhibition. J Pharmacol Exp Ther. 2006 Feb; 316(2):815-21. Davis BB, Morisseau C, Newman JW, Pedersen TL, Hammock BD, Weiss RH. PMID: 16221742.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    269. Lipid sulfates and sulfonates are allosteric competitive inhibitors of the N-terminal phosphatase activity of the mammalian soluble epoxide hydrolase. Biochemistry. 2005 Sep 13; 44(36):12179-87. Tran KL, Aronov PA, Tanaka H, Newman JW, Hammock BD, Morisseau C. PMID: 16142916; PMCID: PMC1473036.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    270. Fluorescent substrates for soluble epoxide hydrolase and application to inhibition studies. Anal Biochem. 2005 Aug 01; 343(1):66-75. Jones PD, Wolf NM, Morisseau C, Whetstone P, Hock B, Hammock BD. PMID: 15963942; PMCID: PMC1447601.
      View in: PubMed   Mentions: 90     Fields:    
    271. Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem. 2005 May 19; 48(10):3621-9. Kim IH, Heirtzler FR, Morisseau C, Nishi K, Tsai HJ, Hammock BD. PMID: 15887969; PMCID: PMC1450255.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimals
    272. Epoxide hydrolases: their roles and interactions with lipid metabolism. Prog Lipid Res. 2005 Jan; 44(1):1-51. Newman JW, Morisseau C, Hammock BD. PMID: 15748653.
      View in: PubMed   Mentions: 189     Fields:    Translation:Animals
    273. Novel mechanism of brain soluble epoxide hydrolase-mediated blood pressure regulation in the spontaneously hypertensive rat. FASEB J. 2005 Apr; 19(6):626-8. Sellers KW, Sun C, Diez-Freire C, Waki H, Morisseau C, Falck JR, Hammock BD, Paton JF, Raizada MK. PMID: 15659536.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    274. Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles. Annu Rev Pharmacol Toxicol. 2005; 45:311-33. Morisseau C, Hammock BD. PMID: 15822179.
      View in: PubMed   Mentions: 181     Fields:    Translation:HumansAnimals
    275. Identification and characterization of an ovary-selective isoform of epoxide hydrolase. Biol Reprod. 2005 Apr; 72(4):968-75. Hennebold JD, Mah K, Perez W, Vance JE, Stouffer RL, Morisseau C, Hammock BD, Adashi EY. PMID: 15601917.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    276. Investigation of the role of a second conserved serine in carboxylesterases via site-directed mutagenesis. Arch Biochem Biophys. 2004 Oct 15; 430(2):247-55. Stok JE, Goloshchapov A, Song C, Wheelock CE, Derbel MB, Morisseau C, Hammock BD. PMID: 15369824.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    277. Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes. J Biol Chem. 2004 Jul 09; 279(28):29863-9. Stok JE, Huang H, Jones PD, Wheelock CE, Morisseau C, Hammock BD. PMID: 15123619.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    278. Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis. Biochemistry. 2004 Apr 27; 43(16):4716-23. Gomez GA, Morisseau C, Hammock BD, Christianson DW. PMID: 15096040.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    279. Design, synthesis, and biological activity of 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility. J Med Chem. 2004 Apr 08; 47(8):2110-22. Kim IH, Morisseau C, Watanabe T, Hammock BD. PMID: 15056008.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimals
    280. Isolation of a strain of Agrobacterium tumefaciens (Rhizobium radiobacter) utilizing methylene urea (ureaformaldehyde) as nitrogen source. Can J Microbiol. 2004 Mar; 50(3):167-74. Koivunen ME, Morisseau C, Horwath WR, Hammock BD. PMID: 15105883.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCellsPHPublic Health
    281. Epoxide hydrolases in the rat epididymis: possible roles in xenobiotic and endogenous fatty acid metabolism. Toxicol Sci. 2004 Apr; 78(2):187-95. DuTeaux SB, Newman JW, Morisseau C, Fairbairn EA, Jelks K, Hammock BD, Miller MG. PMID: 14737000.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    282. Vascular localization of soluble epoxide hydrolase in the human kidney. Am J Physiol Renal Physiol. 2004 Apr; 286(4):F720-6. Yu Z, Davis BB, Morisseau C, Hammock BD, Olson JL, Kroetz DL, Weiss RH. PMID: 14665429.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    283. In vitro metabolism of the mammalian soluble epoxide hydrolase inhibitor, 1-cyclohexyl-3-dodecyl-urea. Drug Metab Dispos. 2003 Jul; 31(7):846-53. Watanabe T, Morisseau C, Newman JW, Hammock BD. PMID: 12814960.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    284. Evaluation of alpha-cyanoesters as fluorescent substrates for examining interindividual variation in general and pyrethroid-selective esterases in human liver microsomes. Anal Biochem. 2003 Apr 15; 315(2):208-22. Wheelock CE, Wheelock AM, Zhang R, Stok JE, Morisseau C, Le Valley SE, Green CE, Hammock BD. PMID: 12689831.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    285. QSAR and classification of murine and human soluble epoxide hydrolase inhibition by urea-like compounds. J Med Chem. 2003 Mar 13; 46(6):1066-80. McElroy NR, Jurs PC, Morisseau C, Hammock BD. PMID: 12620084.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    286. The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1558-63. Newman JW, Morisseau C, Harris TR, Hammock BD. PMID: 12574510; PMCID: PMC149871.
      View in: PubMed   Mentions: 99     Fields:    Translation:Humans
    287. Structural refinement of inhibitors of urea-based soluble epoxide hydrolases. Biochem Pharmacol. 2002 May 01; 63(9):1599-608. Morisseau C, Goodrow MH, Newman JW, Wheelock CE, Dowdy DL, Hammock BD. PMID: 12007563.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    288. Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2222-7. Davis BB, Thompson DA, Howard LL, Morisseau C, Hammock BD, Weiss RH. PMID: 11842228; PMCID: PMC122346.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    289. Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension. Hypertension. 2002 Feb; 39(2 Pt 2):690-4. Imig JD, Zhao X, Capdevila JH, Morisseau C, Hammock BD. PMID: 11882632.
      View in: PubMed   Mentions: 180     Fields:    Translation:Animals
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