Christophe H Morisseau

Title(s)Professional Researcher, Entomology
SchoolAgriculture
AddressOne Shield Avenue
CA 95616
Phone530-752-6571
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Inhibition of Soluble Epoxide Hydrolase Ameliorates Cerebral Blood Flow Autoregulation and Cognition in Alzheimer's Disease and Diabetes-Related Dementia Rat Models. bioRxiv. 2024 Aug 31. Tang C, Border JJ, Zhang H, Gregory A, Bai S, Fang X, Liu Y, Wang S, Hwang SH, Gao W, Morgan GC, Smith J, Bunn D, Cantwell C, Wagner KM, Morisseau C, Yang J, Shin SM, O'Herron P, Bagi Z, Filosa JA, Dong Y, Yu H, Hammock BD, Roman RJ, Fan F. PMID: 39257786; PMCID: PMC11383657.
      View in: PubMed   Mentions:
    2. Triazine herbicide prometryn alters epoxide hydrolase activity and increases cytochrome P450 metabolites in murine livers via lipidomic profiling. Sci Rep. 2024 08 19; 14(1):19135. Sule RO, Morisseau C, Yang J, Hammock BD, Gomes AV. PMID: 39160161; PMCID: PMC11333623.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. Preclinical Evaluation of Soluble Epoxide Hydrolase Inhibitor AMHDU against Neuropathic Pain. Int J Mol Sci. 2024 Aug 14; 25(16). Babkov D, Eliseeva N, Adzhienko K, Bagmetova V, Danilov D, McReynolds CB, Morisseau C, Hammock BD, Burmistrov V. PMID: 39201526; PMCID: PMC11354909.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    4. 4-Phenyl-thiazole-based dual inhibitors of fatty acid amide hydrolase and soluble epoxide hydrolase do not alleviate orofacial inflammatory pain in female rats. BBA Adv. 2024; 6:100119. Carr D, Chin C, Chacon T, Herawi MK, Gonzalez M, West R, Morisseau C, Hammock BD, Pecic S, Kandasamy R. PMID: 39246819; PMCID: PMC11379592.
      View in: PubMed   Mentions:
    5. In vivo -Active Soluble Epoxide Hydrolase-targeting PROTACs with Improved Potency and Stability. bioRxiv. 2024 Jul 24. Nakane K, Morisseau C, Dowker-Key PD, Benitez G, Aguilan JT, Nagai E, Sidoli S, Hammock BD, Bettaieb A, Shinoda K, Kitamura S. PMID: 39211216; PMCID: PMC11361158.
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    6. Design and Synthesis of sEH/HDAC6 Dual-Targeting Inhibitors for the Treatment of Inflammatory Pain. J Med Chem. 2024 Aug 08; 67(15):12887-12911. Xu H, Chen Y, Tong H, Chen L, Morisseau C, Zhou Z, Zhuang J, Song C, Cai P, Liu Z, Hammock BD, Chen G. PMID: 39033411; PMCID: PMC11412156.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    7. Quinolinyl-based multitarget-directed ligands with soluble epoxide hydrolase and fatty acid amide hydrolase inhibitory activities: Synthetic studies and pharmacological evaluations. Heliyon. 2024 Jun 15; 10(11):e32262. Angelia J, Duong L, Yun F, Mesic A, Yuan C, Carr D, Gunari S, Hudson PK, Morisseau C, Hammock BD, Kandasamy R, Pecic S. PMID: 38912512; PMCID: PMC11190605.
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    8. Effects of sEH inhibition on the eicosanoid and cytokine storms in SARS-CoV-2-infected mice. FASEB J. 2024 May 31; 38(10):e23692. Edin ML, Gruzdev A, Graves JP, Lih FB, Morisseau C, Ward JM, Hammock BD, Bosio CM, Zeldin DC. PMID: 38786655; PMCID: PMC11141730.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. The Role of Autophagy in Human Uveal Melanoma and the Development of Potential Disease Biomarkers and Novel Therapeutic Paradigms. Biomedicines. 2024 Feb 19; 12(2). Wang JZ, Paulus P, Niu Y, Zhu L, Morisseau C, Rawling T, Murray M, Hammock BD, Zhou F. PMID: 38398064; PMCID: PMC10886749.
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    10. Design and Synthesis of Dual-Targeting Inhibitors of sEH and HDAC6 for the Treatment of Neuropathic Pain and Lipopolysaccharide-Induced Mortality. J Med Chem. 2024 02 08; 67(3):2095-2117. Chen Y, Sun J, Tong H, Wang J, Cao R, Xu H, Chen L, Morisseau C, Zhang M, Shi Y, Han C, Zhuang J, Jing Y, Liu Z, Hammock BD, Chen G. PMID: 38236416; PMCID: PMC11308793.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    11. Fluorine and chlorine substituted adamantyl-urea as molecular tools for inhibition of human soluble epoxide hydrolase with picomolar efficacy. J Enzyme Inhib Med Chem. 2023 Dec; 38(1):2274797. Burmistrov VV, Morisseau C, Danilov DV, Gladkikh BP, D'yachenko VS, Zefirov NA, Zefirova ON, Butov GM, Hammock BD. PMID: 37975322; PMCID: PMC11003477.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    12. Biosynthesis of magnetosome-nanobody complex in Magnetospirillum gryphiswaldense MSR-1 and a magnetosome-nanobody-based enzyme-linked immunosorbent assay for the detection of tetrabromobisphenol A in water. Anal Bioanal Chem. 2024 Jan; 416(1):141-149. Wu S, Tian J, Xue X, Ma F, Li QX, Morisseau C, Hammock BD, Xu T. PMID: 37934249; PMCID: PMC10829939.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    13. Soluble epoxide hydrolase-targeting PROTAC activates AMPK and inhibits endoplasmic reticulum stress. Biomed Pharmacother. 2023 Dec; 168:115667. Peyman M, Barroso E, Turcu AL, Estrany F, Smith D, Jurado-Aguilar J, Rada P, Morisseau C, Hammock BD, Valverde ÁM, Palomer X, Galdeano C, Vázquez S, Vázquez-Carrera M. PMID: 37826940; PMCID: PMC10786198.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    14. The Generation of a Nanobody-Based ELISA for Human Microsomal Epoxide Hydrolase. Int J Mol Sci. 2023 Sep 28; 24(19). He Q, McCoy MR, Qi M, Morisseau C, Yang H, Xu C, Shey R, Goodman MC, Zhao S, Hammock BD. PMID: 37834144; PMCID: PMC10572367.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Development of a sandwich ELISA for the specific quantitation of hemagglutinin (HA)-tagged proteins during their inducible expression in Escherichia coli. Anal Bioanal Chem. 2023 Sep; 415(23):5563-5574. Yin Z, He Q, Yang H, Morisseau C, El-Sheikh EA, Li D, Hammock BD. PMID: 37505234; PMCID: PMC10473979.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    16. Effects of Individual Circulating FFAs on Plasma and Hepatic FFA Epoxides, Diols, and Epoxide-Diol Ratios as Indices of Soluble Epoxide Hydrolase Activity. Int J Mol Sci. 2023 Jun 28; 24(13). Oh YT, Yang J, Morisseau C, He Q, Hammock B, Youn JH. PMID: 37445935; PMCID: PMC10341844.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    17. Genetic deletion or pharmacological inhibition of soluble epoxide hydrolase attenuated particulate matter 2.5 exposure mediated lung injury. J Hazard Mater. 2023 09 15; 458:131890. Zhang J, Zhang WH, Morisseau C, Zhang M, Dong HJ, Zhu QM, Huo XK, Sun CP, Hammock BD, Ma XC. PMID: 37406527; PMCID: PMC10699546.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    18. Aflatoxin B1 Increases Soluble Epoxide Hydrolase in the Brain and Induces Neuroinflammation and Dopaminergic Neurotoxicity. Int J Mol Sci. 2023 Jun 09; 24(12). Wang W, Wang Y, Wagner KM, Lee RD, Hwang SH, Morisseau C, Wulff H, Hammock BD. PMID: 37373086; PMCID: PMC10298596.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    19. Regulatory lipid vicinal diols counteract the biological activity of epoxy fatty acids and can act as biomarkers and mechanisms for disease progression. Pharmacol Ther. 2023 08; 248:108454. McReynolds C, Hammock B, Morisseau C. PMID: 37268114; PMCID: PMC10529401.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    20. Quantification of soluble epoxide hydrolase inhibitors in experimental and clinical samples using the nanobody-based ELISA. J Pharm Anal. 2023 Sep; 13(9):1013-1023. Yang H, Qi M, He Q, Hwang SH, Yang J, McCoy M, Morisseau C, Zhao S, Hammock BD. PMID: 37842656; PMCID: PMC10568103.
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    21. Screening and Biological Evaluation of Soluble Epoxide Hydrolase Inhibitors: Assessing the Role of Hydrophobicity in the Pharmacophore-Guided Search of Novel Hits. J Chem Inf Model. 2023 05 22; 63(10):3209-3225. Vázquez J, Ginex T, Herrero A, Morisseau C, Hammock BD, Luque FJ. PMID: 37141492; PMCID: PMC10207366.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    22. Neuroprotective effect of herbal extracts inhibiting soluble epoxide hydrolase (sEH) and cyclooxygenase (COX) against chemotherapy-induced cognitive impairment in mice. Biochem Biophys Res Commun. 2023 07 30; 667:64-72. Kulkarni R, Mehta R, Goswami SK, Hammock BD, Morisseau C, Hwang SH, Mallappa O, Azeemuddin MM, Rafiq M, S N M. PMID: 37209564; PMCID: PMC10849156.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    23. Mix-and-Read Nanobody-Based Sandwich Homogeneous Split-Luciferase Assay for the Rapid Detection of Human Soluble Epoxide Hydrolase. Anal Chem. 2023 04 11; 95(14):6038-6045. He Q, McCoy MR, Yang H, Lin M, Cui X, Zhao S, Morisseau C, Li D, Hammock BD. PMID: 36972550; PMCID: PMC10335774.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    24. PROTAC-Mediated Selective Degradation of Cytosolic Soluble Epoxide Hydrolase Enhances ER Stress Reduction. ACS Chem Biol. 2023 04 21; 18(4):884-896. Wang Y, Morisseau C, Takamura A, Wan D, Li D, Sidoli S, Yang J, Wolan DW, Hammock BD, Kitamura S. PMID: 36947831; PMCID: PMC10586715.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    25. Development of a Genetically Encoded Magnetic Platform in Magnetospirillum gryphiswaldense MSR-1 for Downstream Processing of Protein Expression System. Res Sq. 2023 Mar 13. Wu S, Tian J, Xue X, Tang Z, Huang Z, Hammock BD, Morisseau C, Li QX, Xu T. PMID: 36993437; PMCID: PMC10055543.
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    26. Soluble Epoxide Hydrolase Contributes to Cell Senescence and ER Stress in Aging Mice Colon. Int J Mol Sci. 2023 Feb 26; 24(5). Wang W, Wagner KM, Wang Y, Singh N, Yang J, He Q, Morisseau C, Hammock BD. PMID: 36901999; PMCID: PMC10003560.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    27. Macrophage Inactivation by Small Molecule Wedelolactone via Targeting sEH for the Treatment of LPS-Induced Acute Lung Injury. ACS Cent Sci. 2023 Mar 22; 9(3):440-456. Zhang J, Zhang M, Huo XK, Ning J, Yu ZL, Morisseau C, Sun CP, Hammock BD, Ma XC. PMID: 36968547; PMCID: PMC10037491.
      View in: PubMed   Mentions: 9  
    28. Inhibition of Soluble Epoxide Hydrolase Does Not Promote or Aggravate Pulmonary Hypertension in Rats. Cells. 2023 02 20; 12(4). Leuillier M, Platel V, Tu L, Feugray G, Thuillet R, Groussard D, Messaoudi H, Ottaviani M, Chelgham M, Nicol L, Mulder P, Humbert M, Richard V, Morisseau C, Brunel V, Duflot T, Guignabert C, Bellien J. PMID: 36831332; PMCID: PMC9954493.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    29. Structure-Directed Discovery of Potent Soluble Epoxide Hydrolase Inhibitors for the Treatment of Inflammatory Diseases. J Med Chem. 2023 02 23; 66(4):2979-3009. Chen Y, Chen L, Xu H, Cao R, Morisseau C, Zhang M, Shi Y, Hammock BD, Wang J, Zhuang J, Liu Z, Chen G. PMID: 36689364; PMCID: PMC9974930.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    30. Adamantyl-ureas with pyrazoles substituted by fluoroalkanes as soluble epoxide hydrolase inhibitors. J Fluor Chem. 2023 Feb; 266. Burmistrov VV, Morisseau C, Shkineva TK, Danilov DV, Gladkikh B, Butov GM, Fayzullin RR, Dutova TY, Hammock BD, Dalinger IL. PMID: 37638129; PMCID: PMC10457016.
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    31. Novel inhibition of AKR1C3 and androgen receptor axis by PTUPB synergizes enzalutamide treatment in advanced prostate cancer. Oncogene. 2023 02; 42(9):693-707. Yang JC, Xu P, Ning S, Wasielewski LJ, Adomat H, Hwang SH, Morisseau C, Gleave M, Corey E, Gao AC, Lara PN, Evans CP, Hammock BD, Liu C. PMID: 36596844; PMCID: PMC9975039.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    32. Direct targeting of sEH with alisol B alleviated the apoptosis, inflammation, and oxidative stress in cisplatin-induced acute kidney injury. Int J Biol Sci. 2023; 19(1):294-310. Zhang J, Luan ZL, Huo XK, Zhang M, Morisseau C, Sun CP, Hammock BD, Ma XC. PMID: 36594097; PMCID: PMC9760444.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    33. Structure-activity relationship studies of benzothiazole-phenyl analogs as multi-target ligands to alleviate pain without affecting normal behavior. Prostaglandins Other Lipid Mediat. 2023 02; 164:106702. Angelia J, Weng X, Solomatov A, Chin C, Fernandez A, Hudson PK, Morisseau C, Hammock BD, Kandasamy R, Pecic S. PMID: 36529320; PMCID: PMC9879382.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    34. Aflatoxin B1 exposure disrupts the intestinal immune function via a soluble epoxide hydrolase-mediated manner. Ecotoxicol Environ Saf. 2023 Jan 01; 249:114417. Wang W, Wang Y, Yang J, Wagner KM, Hwang SH, Cheng J, Singh N, Edwards P, Morisseau C, Zhang G, Panigrahy D, Hammock BD. PMID: 36525946; PMCID: PMC9879385.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    35. Ureas derived from camphor and fenchone reveal enantiomeric preference of human soluble epoxide hydrolase. Results Chem. 2022 Jan; 4. Burmistrov V, Morisseau C, Pitushkin D, Fayzullin RR, Karlov D, Vernigora A, Kuznetsov Y, Abbas SMH, Butov GM, Hammock BD. PMID: 37601415; PMCID: PMC10438916.
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    36. Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors. J Med Chem. 2022 10 27; 65(20):13660-13680. Codony S, Entrena JM, Calvó-Tusell C, Jora B, González-Cano R, Osuna S, Corpas R, Morisseau C, Pérez B, Barniol-Xicota M, Griñán-Ferré C, Pérez C, Rodríguez-Franco MI, Martínez AL, Loza MI, Pallàs M, Verhelst SHL, Sanfeliu C, Feixas F, Hammock BD, Brea J, Cobos EJ, Vázquez S. PMID: 36222708; PMCID: PMC9620236.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    37. Soluble Epoxide Hydrolase Is Associated with Postprandial Anxiety Decrease in Healthy Adult Women. Int J Mol Sci. 2022 Oct 05; 23(19). Nguyen N, Morisseau C, Li D, Yang J, Lam E, Woodside DB, Hammock BD, Shih PB. PMID: 36233100; PMCID: PMC9569757.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    38. Anti-Inflammatory Activity of Soluble Epoxide Hydrolase Inhibitors Based on Selenoureas Bearing an Adamantane Moiety. Int J Mol Sci. 2022 Sep 14; 23(18). Burmistrov V, Morisseau C, Babkov DA, Golubeva T, Pitushkin D, Sokolova EV, Vasipov V, Kuznetsov Y, Bazhenov SV, Novoyatlova US, Bondarev NA, Manukhov IV, Osipova V, Berberova N, Spasov AA, Butov GM, Hammock BD. PMID: 36142611; PMCID: PMC9501280.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    39. The epoxy fatty acid pathway enhances cAMP in mammalian cells through multiple mechanisms. Prostaglandins Other Lipid Mediat. 2022 10; 162:106662. Matsumoto N, Singh N, Lee KS, Barnych B, Morisseau C, Hammock BD. PMID: 35779854; PMCID: PMC9530012.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    40. Improved ELISA for linoleate-derived diols in human plasma utilizing a polyHRP-based secondary tracer. Anal Methods. 2022 05 13; 14(18):1810-1819. Singh N, Li D, McReynolds CB, Morisseau C, Hammock BD. PMID: 35481804; PMCID: PMC9116231.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    41. The Role of Hydrolases in Biology and Xenobiotics Metabolism. Int J Mol Sci. 2022 Apr 28; 23(9). Morisseau C. PMID: 35563260; PMCID: PMC9105290.
      View in: PubMed   Mentions: 3     Fields:    
    42. CRISPR/Cas9-mediated inactivation of the phosphatase activity of soluble epoxide hydrolase prevents obesity and cardiac ischemic injury. J Adv Res. 2023 01; 43:163-174. Leuillier M, Duflot T, Ménoret S, Messaoudi H, Djerada Z, Groussard D, Denis RGP, Chevalier L, Karoui A, Panthu B, Thiébaut PA, Schmitz-Afonso I, Nobis S, Campart C, Henry T, Sautreuil C, Luquet SH, Beseme O, Féliu C, Peyret H, Nicol L, Henry JP, Renet S, Mulder P, Wan D, Tesson L, Heslan JM, Duché A, Jacques S, Ziegler F, Brunel V, Rautureau GJP, Monteil C, do Rego JL, do Rego JC, Afonso C, Hammock B, Madec AM, Pinet F, Richard V, Anegon I, Guignabert C, Morisseau C, Bellien J. PMID: 36585106; PMCID: PMC9811321.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    43. Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease. J Med Chem. 2022 03 24; 65(6):4909-4925. Codony S, Pont C, Griñán-Ferré C, Di Pede-Mattatelli A, Calvó-Tusell C, Feixas F, Osuna S, Jarné-Ferrer J, Naldi M, Bartolini M, Loza MI, Brea J, Pérez B, Bartra C, Sanfeliu C, Juárez-Jiménez J, Morisseau C, Hammock BD, Pallàs M, Vázquez S, Muñoz-Torrero D. PMID: 35271276; PMCID: PMC8958510.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    44. Kurarinone alleviated Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal model. Proc Natl Acad Sci U S A. 2022 03 01; 119(9). Sun CP, Zhou JJ, Yu ZL, Huo XK, Zhang J, Morisseau C, Hammock BD, Ma XC. PMID: 35217618; PMCID: PMC8892522.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    45. A Fast and Selective Approach for Profiling Vicinal Diols Using Liquid Chromatography-Post Column Derivatization-Double Precursor Ion Scanning Mass Spectrometry. Molecules. 2022 Jan 03; 27(1). Wan D, Morisseau C, Hammock BD, Yang J. PMID: 35011515; PMCID: PMC8747065.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    46. 2-(Piperidin-4-yl)acetamides as Potent Inhibitors of Soluble Epoxide Hydrolase with Anti-Inflammatory Activity. Pharmaceuticals (Basel). 2021 Dec 17; 14(12). Martín-López J, Codony S, Bartra C, Morisseau C, Loza MI, Sanfeliu C, Hammock BD, Brea J, Vázquez S. PMID: 34959721; PMCID: PMC8703317.
      View in: PubMed   Mentions: 2  
    47. Soluble Epoxide Hydrolase Deletion Limits High-Fat Diet-Induced Inflammation. Front Pharmacol. 2021; 12:778470. Wagner KM, Yang J, Morisseau C, Hammock BD. PMID: 34975481; PMCID: PMC8719166.
      View in: PubMed   Mentions: 1  
    48. New Alkoxy- Analogues of Epoxyeicosatrienoic Acids Attenuate Cisplatin Nephrotoxicity In Vitro via Reduction of Mitochondrial Dysfunction, Oxidative Stress, Mitogen-Activated Protein Kinase Signaling, and Caspase Activation. Chem Res Toxicol. 2021 12 20; 34(12):2579-2591. Singh N, Vik A, Lybrand DB, Morisseau C, Hammock BD. PMID: 34817988; PMCID: PMC8853703.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    49. Further exploration of the structure-activity relationship of dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors. Bioorg Med Chem. 2021 12 01; 51:116507. Wilt S, Kodani S, Valencia L, Hudson PK, Sanchez S, Quintana T, Morisseau C, Hammock BD, Kandasamy R, Pecic S. PMID: 34794001; PMCID: PMC8900675.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    50. Species Differences in Metabolism of Soluble Epoxide Hydrolase Inhibitor, EC1728, Highlight the Importance of Clinically Relevant Screening Mechanisms in Drug Development. Molecules. 2021 Aug 19; 26(16). McReynolds CB, Yang J, Guedes A, Morisseau C, Garcia R, Knych H, Tearney C, Hamamoto B, Hwang SH, Wagner K, Hammock BD. PMID: 34443621; PMCID: PMC8399023.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    51. Inhibition of sEH via stabilizing the level of EETs alleviated Alzheimer's disease through GSK3β signaling pathway. Food Chem Toxicol. 2021 Oct; 156:112516. Sun CP, Zhang XY, Zhou JJ, Huo XK, Yu ZL, Morisseau C, Hammock BD, Ma XC. PMID: 34411643; PMCID: PMC8889936.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    52. EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence. Elife. 2021 08 03; 10. Gautheron J, Morisseau C, Chung WK, Zammouri J, Auclair M, Baujat G, Capel E, Moulin C, Wang Y, Yang J, Hammock BD, Cerame B, Phan F, Fève B, Vigouroux C, Andreelli F, Jeru I. PMID: 34342583; PMCID: PMC8331186.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    53. Differential Effects of 17,18-EEQ and 19,20-EDP Combined with Soluble Epoxide Hydrolase Inhibitor t-TUCB on Diet-Induced Obesity in Mice. Int J Mol Sci. 2021 Jul 31; 22(15). Yang Y, Xu X, Wu H, Yang J, Chen J, Morisseau C, Hammock BD, Bettaieb A, Zhao L. PMID: 34361032; PMCID: PMC8347952.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    54. Role of Epoxide Hydrolases and Cytochrome P450s on Metabolism of KZR-616, a First-in-Class Selective Inhibitor of the Immunoproteasome. Drug Metab Dispos. 2021 09; 49(9):810-821. Fang Y, Johnson H, Anderl JL, Muchamuel T, McMinn D, Morisseau C, Hammock BD, Kirk C, Wang J. PMID: 34234005.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    55. Discovery of memantyl urea derivatives as potent soluble epoxide hydrolase inhibitors against lipopolysaccharide-induced sepsis. Eur J Med Chem. 2021 Nov 05; 223:113678. Du F, Sun W, Morisseau C, Hammock BD, Bao X, Liu Q, Wang C, Zhang T, Yang H, Zhou J, Xiao W, Liu Z, Chen G. PMID: 34218083; PMCID: PMC8877601.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    56. Molecular docking-guided synthesis of NSAID-glucosamine bioconjugates and their evaluation as COX-1/COX-2 inhibitors with potentially reduced gastric toxicity. Chem Biol Drug Des. 2021 07; 98(1):102-113. Jones Lipinski RA, Thillier Y, Morisseau C, Sebastiano CS, Smith BC, Hall CD, Katritzky AR. PMID: 33955172; PMCID: PMC8281356.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    57. Genetic deficiency or pharmacological inhibition of soluble epoxide hydrolase ameliorates high fat diet-induced pancreatic β-cell dysfunction and loss. Free Radic Biol Med. 2021 08 20; 172:48-57. Koike S, Hsu MF, Bettaieb A, Chu B, Matsumoto N, Morisseau C, Havel PJ, Huising MO, Hammock BD, Haj FG. PMID: 34038767; PMCID: PMC9901526.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    58. Activity of sEH and Oxidant Status during Systemic Bovine Coliform Mastitis. Antioxidants (Basel). 2021 May 20; 10(5). Mavangira V, Kuhn MJ, Abuelo A, Morisseau C, Hammock BD, Sordillo LM. PMID: 34065244; PMCID: PMC8161397.
      View in: PubMed   Mentions: 3  
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    121. Reduced carboxylesterase 1 is associated with endothelial injury in methamphetamine-induced pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2017 08 01; 313(2):L252-L266. Orcholski ME, Khurshudyan A, Shamskhou EA, Yuan K, Chen IY, Kodani SD, Morisseau C, Hammock BD, Hong EM, Alexandrova L, Alastalo TP, Berry G, Zamanian RT, de Jesus Perez VA. PMID: 28473326; PMCID: PMC5582936.
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    148. Aerobic exercise-based rehabilitation affects the activities of progenitor endothelial cells through EETs pathway. Med Hypotheses. 2015 Dec; 85(6):1037-8. Deng LM, Li XP, Xu DY, Morisseau C, Chiamvimonvat N, Hammock BD. PMID: 26454561; PMCID: PMC5003087.
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    154. High salt diet modulates vascular response in A2AAR (+/+) and A 2AAR (-/-) mice: role of sEH, PPARγ, and K ATP channels. Mol Cell Biochem. 2015 Jun; 404(1-2):87-96. Pradhan I, Ledent C, Mustafa SJ, Morisseau C, Nayeem MA. PMID: 25739357; PMCID: PMC4470368.
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    156. A Photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase. Chembiochem. 2015 Mar 23; 16(5):766-71. Nollmann FI, Heinrich AK, Brachmann AO, Morisseau C, Mukherjee K, Casanova-Torres ÁM, Strobl F, Kleinhans D, Kinski S, Schultz K, Beeton ML, Kaiser M, Chu YY, Phan Ke L, Thanwisai A, Bozhüyük KA, Chantratita N, Götz F, Waterfield NR, Vilcinskas A, Stelzer EH, Goodrich-Blair H, Hammock BD, Bode HB. PMID: 25711603; PMCID: PMC4486325.
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    182. Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models. Eur J Pharm Sci. 2013 Mar 12; 48(4-5):619-27. Liu JY, Lin YP, Qiu H, Morisseau C, Rose TE, Hwang SH, Chiamvimonvat N, Hammock BD. PMID: 23291046; PMCID: PMC3596469.
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    183. Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties. Nat Commun. 2013; 4:1840. de Medina P, Paillasse MR, Segala G, Voisin M, Mhamdi L, Dalenc F, Lacroix-Triki M, Filleron T, Pont F, Saati TA, Morisseau C, Hammock BD, Silvente-Poirot S, Poirot M. PMID: 23673625; PMCID: PMC3674249.
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    184. Cloning and characterization of a microsomal epoxide hydrolase from Heliothis virescens. Insect Biochem Mol Biol. 2013 Mar; 43(3):219-28. Kamita SG, Yamamoto K, Dadala MM, Pha K, Morisseau C, Escaich A, Hammock BD. PMID: 23276675; PMCID: PMC3577957.
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    185. Comparative efficacy of 3 soluble epoxide hydrolase inhibitors in rat neuropathic and inflammatory pain models. Eur J Pharmacol. 2013 Jan 30; 700(1-3):93-101. Wagner K, Inceoglu B, Dong H, Yang J, Hwang SH, Jones P, Morisseau C, Hammock BD. PMID: 23276668; PMCID: PMC3578047.
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    186. Beneficial effects of inhibition of soluble epoxide hydrolase on glucose homeostasis and islet damage in a streptozotocin-induced diabetic mouse model. Prostaglandins Other Lipid Mediat. 2013 Jul-Aug; 104-105:42-8. Chen L, Fan C, Zhang Y, Bakri M, Dong H, Morisseau C, Maddipati KR, Luo P, Wang CY, Hammock BD, Wang MH. PMID: 23247129; PMCID: PMC4052893.
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    187. Förster resonance energy transfer competitive displacement assay for human soluble epoxide hydrolase. Anal Biochem. 2013 Mar 15; 434(2):259-68. Lee KS, Morisseau C, Yang J, Wang P, Hwang SH, Hammock BD. PMID: 23219719; PMCID: PMC3632402.
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    188. Development of an HTS assay for EPHX2 phosphatase activity and screening of nontargeted libraries. Anal Biochem. 2013 Mar 01; 434(1):105-11. Morisseau C, Sahdeo S, Cortopassi G, Hammock BD. PMID: 23219563; PMCID: PMC3557602.
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    189. Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett. 2013 Jan 15; 23(2):417-21. Pecic S, Pakhomova S, Newcomer ME, Morisseau C, Hammock BD, Zhu Z, Rinderspacher A, Deng SX. PMID: 23237835; PMCID: PMC3541548.
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    190. Adenosine A2A receptor modulates vascular response in soluble epoxide hydrolase-null mice through CYP-epoxygenases and PPARγ. Am J Physiol Regul Integr Comp Physiol. 2013 Jan 01; 304(1):R23-32. Nayeem MA, Pradhan I, Mustafa SJ, Morisseau C, Falck JR, Zeldin DC. PMID: 23152114; PMCID: PMC3543649.
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    191. Development of On-line Liquid Chromatography-Biochemical Detection for Soluble Epoxide Hydrolase Inhibitors in Mixtures. Chromatographia. 2013 Jan 01; 76(1-2):13-21. Falck D, Schebb NH, Prihatiningtyas S, Zhang J, Heus F, Morisseau C, Kool J, Hammock BD, Niessen WM. PMID: 23526703; PMCID: PMC3601784.
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    192. Hepoxilin A(3) facilitates neutrophilic breach of lipoxygenase-expressing airway epithelial barriers. J Immunol. 2012 Nov 15; 189(10):4960-9. Tamang DL, Pirzai W, Priebe GP, Traficante DC, Pier GB, Falck JR, Morisseau C, Hammock BD, McCormick BA, Gronert K, Hurley BP. PMID: 23045615; PMCID: PMC3490410.
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    193. Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health. Annu Rev Pharmacol Toxicol. 2013; 53:37-58. Morisseau C, Hammock BD. PMID: 23020295; PMCID: PMC3578707.
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    194. Biologically active ester derivatives as potent inhibitors of the soluble epoxide hydrolase. Bioorg Med Chem Lett. 2012 Sep 15; 22(18):5889-92. Kim IH, Nishi K, Kasagami T, Morisseau C, Liu JY, Tsai HJ, Hammock BD. PMID: 22901393; PMCID: PMC3432147.
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    195. EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides. J Lipid Res. 2012 Oct; 53(10):2038-2045. Decker M, Adamska M, Cronin A, Di Giallonardo F, Burgener J, Marowsky A, Falck JR, Morisseau C, Hammock BD, Gruzdev A, Zeldin DC, Arand M. PMID: 22798687; PMCID: PMC3435537.
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    196. Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of type I diabetes. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11390-5. Inceoglu B, Wagner KM, Yang J, Bettaieb A, Schebb NH, Hwang SH, Morisseau C, Haj FG, Hammock BD. PMID: 22733772; PMCID: PMC3396532.
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    197. Role of epoxide hydrolases in lipid metabolism. Biochimie. 2013 Jan; 95(1):91-5. Morisseau C. PMID: 22722082; PMCID: PMC3495083.
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    198. Soluble epoxide hydrolase expression in a porcine model of arteriovenous graft stenosis and anti-inflammatory effects of a soluble epoxide hydrolase inhibitor. Am J Physiol Cell Physiol. 2012 Aug 01; 303(3):C278-90. Sanders WG, Morisseau C, Hammock BD, Cheung AK, Terry CM. PMID: 22621785; PMCID: PMC3423029.
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    199. A potent soluble epoxide hydrolase inhibitor, t-AUCB, acts through PPARγ to modulate the function of endothelial progenitor cells from patients with acute myocardial infarction. Int J Cardiol. 2013 Aug 20; 167(4):1298-304. Xu DY, Davis BB, Wang ZH, Zhao SP, Wasti B, Liu ZL, Li N, Morisseau C, Chiamvimonvat N, Hammock BD. PMID: 22525341; PMCID: PMC3821736.
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    200. Screening a library of 1600 adamantyl ureas for anti-Mycobacterium tuberculosis activity in vitro and for better physical chemical properties for bioavailability. Bioorg Med Chem. 2012 May 15; 20(10):3255-62. Scherman MS, North EJ, Jones V, Hess TN, Grzegorzewicz AE, Kasagami T, Kim IH, Merzlikin O, Lenaerts AJ, Lee RE, Jackson M, Morisseau C, McNeil MR. PMID: 22522007; PMCID: PMC3345085.
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    201. Structure-based optimization of the piperazino-containing 1,3-disubstituted ureas affording sub-nanomolar inhibitors of soluble epoxide hydrolase. Medchemcomm. 2012 Mar 01; (3):379-384. Huang SX, Cao B, Morisseau C, Jin Y, Hammock BD, Long YQ. PMID: 25225606; PMCID: PMC4163146.
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    202. Role of soluble epoxide hydrolase phosphatase activity in the metabolism of lysophosphatidic acids. Biochem Biophys Res Commun. 2012 Mar 23; 419(4):796-800. Morisseau C, Schebb NH, Dong H, Ulu A, Aronov PA, Hammock BD. PMID: 22387545; PMCID: PMC3313618.
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    203. Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nat Chem Biol. 2012 Feb 19; 8(4):334-41. Grzegorzewicz AE, Pham H, Gundi VA, Scherman MS, North EJ, Hess T, Jones V, Gruppo V, Born SE, Korduláková J, Chavadi SS, Morisseau C, Lenaerts AJ, Lee RE, McNeil MR, Jackson M. PMID: 22344175; PMCID: PMC3307863.
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    204. Development of monoclonal antibodies to human microsomal epoxide hydrolase and analysis of "preneoplastic antigen"-like molecules. Toxicol Appl Pharmacol. 2012 Apr 01; 260(1):17-26. Duan H, Yoshimura K, Kobayashi N, Sugiyama K, Sawada J, Saito Y, Morisseau C, Hammock BD, Akatsuka T. PMID: 22310175; PMCID: PMC3319115.
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    205. Monoclonal antibodies reveal multiple forms of expression of human microsomal epoxide hydrolase. Toxicol Appl Pharmacol. 2012 Apr 01; 260(1):27-34. Duan H, Takagi A, Kayano H, Koyama I, Morisseau C, Hammock BD, Akatsuka T. PMID: 22306621; PMCID: PMC3319120.
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    206. Corncob bedding alters the effects of estrogens on aggressive behavior and reduces estrogen receptor-α expression in the brain. Endocrinology. 2012 Feb; 153(2):949-53. Villalon Landeros R, Morisseau C, Yoo HJ, Fu SH, Hammock BD, Trainor BC. PMID: 22186416; PMCID: PMC3275391.
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    207. N-terminal domain of soluble epoxide hydrolase negatively regulates the VEGF-mediated activation of endothelial nitric oxide synthase. Cardiovasc Res. 2012 Jan 01; 93(1):120-9. Hou HH, Hammock BD, Su KH, Morisseau C, Kou YR, Imaoka S, Oguro A, Shyue SK, Zhao JF, Lee TS. PMID: 22072631; PMCID: PMC3243038.
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    208. Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett. 2012 Jan 01; 22(1):601-5. Pecic S, Deng SX, Morisseau C, Hammock BD, Landry DW. PMID: 22079754; PMCID: PMC3337727.
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    209. Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats. Exp Diabetes Res. 2012; 2012:758614. Iyer A, Kauter K, Alam MA, Hwang SH, Morisseau C, Hammock BD, Brown L. PMID: 22007192; PMCID: PMC3191770.
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    210. The structure-activity relationship of urea derivatives as anti-tuberculosis agents. Bioorg Med Chem. 2011 Sep 15; 19(18):5585-95. Brown JR, North EJ, Hurdle JG, Morisseau C, Scarborough JS, Sun D, Korduláková J, Scherman MS, Jones V, Grzegorzewicz A, Crew RM, Jackson M, McNeil MR, Lee RE. PMID: 21840723; PMCID: PMC3176295.
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    211. Inhibition of soluble epoxide hydrolase contributes to the anti-inflammatory effect of antimicrobial triclocarban in a murine model. Toxicol Appl Pharmacol. 2011 Sep 01; 255(2):200-6. Liu JY, Qiu H, Morisseau C, Hwang SH, Tsai HJ, Ulu A, Chiamvimonvat N, Hammock BD. PMID: 21741984; PMCID: PMC3156297.
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    212. Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors. Anal Bioanal Chem. 2011 May; 400(5):1359-66. Schebb NH, Huby M, Morisseau C, Hwang SH, Hammock BD. PMID: 21479549; PMCID: PMC3081056.
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    213. Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase. J Med Chem. 2011 Apr 28; 54(8):3037-50. Hwang SH, Wagner KM, Morisseau C, Liu JY, Dong H, Wecksler AT, Hammock BD. PMID: 21434686; PMCID: PMC3281519.
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    214. Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in a rat liver cell line. Toxicol Appl Pharmacol. 2011 May 15; 253(1):45-56. Barhoumi R, Mouneimne Y, Ramos E, Morisseau C, Hammock BD, Safe S, Parrish AR, Burghardt RC. PMID: 21420996; PMCID: PMC3081912.
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    215. Investigation of human exposure to triclocarban after showering and preliminary evaluation of its biological effects. Environ Sci Technol. 2011 Apr 01; 45(7):3109-15. Schebb NH, Inceoglu B, Ahn KC, Morisseau C, Gee SJ, Hammock BD. PMID: 21381656; PMCID: PMC3470465.
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    216. Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP. Proc Natl Acad Sci U S A. 2011 Mar 22; 108(12):5093-7. Inceoglu B, Wagner K, Schebb NH, Morisseau C, Jinks SL, Ulu A, Hegedus C, Rose T, Brosnan R, Hammock BD. PMID: 21383170; PMCID: PMC3064364.
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    217. Development of fluorescent substrates for microsomal epoxide hydrolase and application to inhibition studies. Anal Biochem. 2011 Jul 01; 414(1):154-62. Morisseau C, Bernay M, Escaich A, Sanborn JR, Lango J, Hammock BD. PMID: 21371418; PMCID: PMC3090455.
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    218. Soluble epoxide hydrolase in the generation and maintenance of high blood pressure in spontaneously hypertensive rats. Am J Physiol Endocrinol Metab. 2011 Apr; 300(4):E691-8. Koeners MP, Wesseling S, Ulu A, Sepúlveda RL, Morisseau C, Braam B, Hammock BD, Joles JA. PMID: 21266668; PMCID: PMC3074945.
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    219. Redox regulation of soluble epoxide hydrolase by 15-deoxy-delta-prostaglandin J2 controls coronary hypoxic vasodilation. Circ Res. 2011 Feb 04; 108(3):324-34. Charles RL, Burgoyne JR, Mayr M, Weldon SM, Hubner N, Dong H, Morisseau C, Hammock BD, Landar A, Eaton P. PMID: 21164107; PMCID: PMC3259859.
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    220. Incorporation of piperazino functionality into 1,3-disubstituted urea as the tertiary pharmacophore affording potent inhibitors of soluble epoxide hydrolase with improved pharmacokinetic properties. J Med Chem. 2010 Dec 09; 53(23):8376-86. Huang SX, Li HY, Liu JY, Morisseau C, Hammock BD, Long YQ. PMID: 21070033; PMCID: PMC3070159.
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    221. 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain. J Med Chem. 2010 Oct 14; 53(19):7067-75. Rose TE, Morisseau C, Liu JY, Inceoglu B, Jones PD, Sanborn JR, Hammock BD. PMID: 20812725; PMCID: PMC3285450.
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    222. Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease. PLoS One. 2010 Aug 04; 5(8):e11979. Jung O, Jansen F, Mieth A, Barbosa-Sicard E, Pliquett RU, Babelova A, Morisseau C, Hwang SH, Tsai C, Hammock BD, Schaefer L, Geisslinger G, Amann K, Brandes RP. PMID: 20694143; PMCID: PMC2915917.
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    223. Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids. J Lipid Res. 2010 Dec; 51(12):3481-90. Morisseau C, Inceoglu B, Schmelzer K, Tsai HJ, Jinks SL, Hegedus CM, Hammock BD. PMID: 20664072; PMCID: PMC2975720.
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    224. Function of phenylalanine 259 and threonine 314 within the substrate binding pocket of the juvenile hormone esterase of Manduca sexta. Biochemistry. 2010 May 04; 49(17):3733-42. Kamita SG, Wogulis MD, Law CS, Morisseau C, Tanaka H, Huang H, Wilson DK, Hammock BD. PMID: 20307057; PMCID: PMC3570046.
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    225. Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis. J Pharmacol Exp Ther. 2010 Aug; 334(2):430-8. Luo P, Chang HH, Zhou Y, Zhang S, Hwang SH, Morisseau C, Wang CY, Inscho EW, Hammock BD, Wang MH. PMID: 20439437; PMCID: PMC2913776.
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    226. Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase. Am J Physiol Regul Integr Comp Physiol. 2010 Jul; 299(1):R325-33. Nayeem MA, Zeldin DC, Boegehold MA, Morisseau C, Marowsky A, Ponnoth DS, Roush KP, Falck JR. PMID: 20427718; PMCID: PMC2904154.
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    227. Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs. Eur J Pharm Sci. 2010 Jun 14; 40(3):222-38. Tsai HJ, Hwang SH, Morisseau C, Yang J, Jones PD, Kasagami T, Kim IH, Hammock BD. PMID: 20359531; PMCID: PMC3285443.
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    228. Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice. Arterioscler Thromb Vasc Biol. 2010 May; 30(5):909-14. Revermann M, Schloss M, Barbosa-Sicard E, Mieth A, Liebner S, Morisseau C, Geisslinger G, Schermuly RT, Fleming I, Hammock BD, Brandes RP. PMID: 20224052; PMCID: PMC2919323.
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    229. Impact of epoxyeicosatrienoic acids in lung ischemia-reperfusion injury. Microcirculation. 2010 Feb; 17(2):137-46. Townsley MI, Morisseau C, Hammock B, King JA. PMID: 20163540; PMCID: PMC2923642.
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    230. Crystal structure of the cystic fibrosis transmembrane conductance regulator inhibitory factor Cif reveals novel active-site features of an epoxide hydrolase virulence factor. J Bacteriol. 2010 Apr; 192(7):1785-95. Bahl CD, Morisseau C, Bomberger JM, Stanton BA, Hammock BD, O'Toole GA, Madden DR. PMID: 20118260; PMCID: PMC2838060.
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    231. Tryptophan fluorescence quenching by enzyme inhibitors as a tool for enzyme active site structure investigation: epoxide hydrolase. Curr Pharm Biotechnol. 2009 Sep; 10(6):589-99. Matveeva EG, Morisseau C, Goodrow MH, Mullin C, Hammock BD. PMID: 19619123; PMCID: PMC2861369.
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    232. 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition. J Med Chem. 2009 Aug 27; 52(16):5069-75. Falck JR, Kodela R, Manne R, Atcha KR, Puli N, Dubasi N, Manthati VL, Capdevila JH, Yi XY, Goldman DH, Morisseau C, Hammock BD, Campbell WB. PMID: 19653681; PMCID: PMC2888647.
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    233. Inhibition of the soluble epoxide hydrolase by tyrosine nitration. J Biol Chem. 2009 Oct 09; 284(41):28156-28163. Barbosa-Sicard E, Frömel T, Keserü B, Brandes RP, Morisseau C, Hammock BD, Braun T, Krüger M, Fleming I. PMID: 19704161; PMCID: PMC2788866.
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    234. Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo. Mol Cancer Ther. 2009 Aug; 8(8):2193-203. Liu JY, Park SH, Morisseau C, Hwang SH, Hammock BD, Weiss RH. PMID: 19671760; PMCID: PMC2728155.
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    235. Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key enzymes and receptors. Environ Health Perspect. 2009 Dec; 117(12):1867-72. Morisseau C, Merzlikin O, Lin A, He G, Feng W, Padilla I, Denison MS, Pessah IN, Hammock BD. PMID: 20049205; PMCID: PMC2799460.
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    236. Expression and regulation of soluble epoxide hydrolase in adipose tissue. Obesity (Silver Spring). 2010 Mar; 18(3):489-98. De Taeye BM, Morisseau C, Coyle J, Covington JW, Luria A, Yang J, Murphy SB, Friedman DB, Hammock BB, Vaughan DE. PMID: 19644452; PMCID: PMC2864128.
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    237. Alteration in plasma testosterone levels in male mice lacking soluble epoxide hydrolase. Am J Physiol Endocrinol Metab. 2009 Aug; 297(2):E375-83. Luria A, Morisseau C, Tsai HJ, Yang J, Inceoglu B, De Taeye B, Watkins SM, Wiest MM, German JB, Hammock BD. PMID: 19458064; PMCID: PMC2724109.
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    238. Novel and highly sensitive fluorescent assay for leucine aminopeptidases. Anal Biochem. 2009 Aug 01; 391(1):11-6. Huang H, Tanaka H, Hammock BD, Morisseau C. PMID: 19433052; PMCID: PMC2748848.
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    239. Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats. J Hypertens. 2009 Feb; 27(2):322-31. Revermann M, Barbosa-Sicard E, Dony E, Schermuly RT, Morisseau C, Geisslinger G, Fleming I, Hammock BD, Brandes RP. PMID: 19226702; PMCID: PMC2863009.
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    240. Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities. Bioorg Med Chem Lett. 2009 Mar 15; 19(6):1784-9. Kasagami T, Kim IH, Tsai HJ, Nishi K, Hammock BD, Morisseau C. PMID: 19216074; PMCID: PMC2900318.
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    241. Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation. Br J Pharmacol. 2009 Jan; 156(2):284-96. Liu JY, Tsai HJ, Hwang SH, Jones PD, Morisseau C, Hammock BD. PMID: 19154430; PMCID: PMC2697843.
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    242. Differential subcellular distribution and colocalization of the microsomal and soluble epoxide hydrolases in cultured neonatal rat brain cortical astrocytes. J Neurosci Res. 2009 Jan; 87(1):218-27. Rawal S, Morisseau C, Hammock BD, Shivachar AC. PMID: 18711743; PMCID: PMC3592782.
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    243. Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways. Proc Natl Acad Sci U S A. 2008 Dec 02; 105(48):18901-6. Inceoglu B, Jinks SL, Ulu A, Hegedus CM, Georgi K, Schmelzer KR, Wagner K, Jones PD, Morisseau C, Hammock BD. PMID: 19028872; PMCID: PMC2596245.
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    244. Soluble epoxide hydrolase inhibitors reduce the development of atherosclerosis in apolipoprotein e-knockout mouse model. J Cardiovasc Pharmacol. 2008 Oct; 52(4):314-23. Ulu A, Davis BB, Tsai HJ, Kim IH, Morisseau C, Inceoglu B, Fiehn O, Hammock BD, Weiss RH. PMID: 18791465; PMCID: PMC2637359.
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    245. Inhibition of soluble epoxide hydrolase does not protect against endotoxin-mediated hepatic inflammation. J Pharmacol Exp Ther. 2008 Dec; 327(3):707-15. Fife KL, Liu Y, Schmelzer KR, Tsai HJ, Kim IH, Morisseau C, Hammock BD, Kroetz DL. PMID: 18815352; PMCID: PMC2761654.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    246. Discovery of potent non-urea inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett. 2009 Apr 15; 19(8):2354-9. Xie Y, Liu Y, Gong G, Smith DH, Yan F, Rinderspacher A, Feng Y, Zhu Z, Li X, Deng SX, Branden L, Vidovic D, Chung C, Schürer S, Morisseau C, Hammock BD, Landry DW. PMID: 19303288; PMCID: PMC2738751.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    247. The molecular structure of epoxide hydrolase B from Mycobacterium tuberculosis and its complex with a urea-based inhibitor. J Mol Biol. 2008 Sep 12; 381(4):897-912. Biswal BK, Morisseau C, Garen G, Cherney MM, Garen C, Niu C, Hammock BD, James MN. PMID: 18585390; PMCID: PMC2866126.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    248. Gerry Brooks and epoxide hydrolases: four decades to a pharmaceutical. Pest Manag Sci. 2008 Jun; 64(6):594-609. Morisseau C, Hammock BD. PMID: 18383502.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    249. Hydrolysis of cis- and trans-epoxyeicosatrienoic acids by rat red blood cells. J Pharmacol Exp Ther. 2008 Jul; 326(1):330-7. Jiang H, Zhu AG, Mamczur M, Morisseau C, Hammock BD, Falck JR, McGiff JC. PMID: 18445784; PMCID: PMC2732189.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    250. Attenuation of cisplatin nephrotoxicity by inhibition of soluble epoxide hydrolase. Cell Biol Toxicol. 2009 Jun; 25(3):217-25. Parrish AR, Chen G, Burghardt RC, Watanabe T, Morisseau C, Hammock BD. PMID: 18386137; PMCID: PMC3033346.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    251. Development of metabolically stable inhibitors of Mammalian microsomal epoxide hydrolase. Chem Res Toxicol. 2008 Apr; 21(4):951-7. Morisseau C, Newman JW, Wheelock CE, Hill Iii T, Morin D, Buckpitt AR, Hammock BD. PMID: 18363382.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    252. Transcriptional regulation of the human soluble epoxide hydrolase gene EPHX2. Biochim Biophys Acta. 2008 Jan; 1779(1):17-27. Tanaka H, Kamita SG, Wolf NM, Harris TR, Wu Z, Morisseau C, Hammock BD. PMID: 18078836; PMCID: PMC2699939.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    253. 1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic properties. J Med Chem. 2007 Oct 18; 50(21):5217-26. Kim IH, Tsai HJ, Nishi K, Kasagami T, Morisseau C, Hammock BD. PMID: 17894481; PMCID: PMC2543935.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    254. Epoxyeicosatrienoic acids regulate Trp channel dependent Ca2+ signaling and hyperpolarization in endothelial cells. Arterioscler Thromb Vasc Biol. 2007 Dec; 27(12):2612-8. Fleming I, Rueben A, Popp R, Fisslthaler B, Schrodt S, Sander A, Haendeler J, Falck JR, Morisseau C, Hammock BD, Busse R. PMID: 17872452.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    255. Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem. 2007 Aug 09; 50(16):3825-40. Hwang SH, Tsai HJ, Liu JY, Morisseau C, Hammock BD. PMID: 17616115; PMCID: PMC2596069.
      View in: PubMed   Mentions: 143     Fields:    Translation:HumansAnimalsCells
    256. Increasing or stabilizing renal epoxyeicosatrienoic acid production attenuates abnormal renal function and hypertension in obese rats. Am J Physiol Renal Physiol. 2007 Jul; 293(1):F342-9. Huang H, Morisseau C, Wang J, Yang T, Falck JR, Hammock BD, Wang MH. PMID: 17442729.
      View in: PubMed   Mentions: 41     Fields:    Translation:Animals
    257. Soluble epoxide hydrolase: a novel therapeutic target in stroke. J Cereb Blood Flow Metab. 2007 Dec; 27(12):1931-40. Zhang W, Koerner IP, Noppens R, Grafe M, Tsai HJ, Morisseau C, Luria A, Hammock BD, Falck JR, Alkayed NJ. PMID: 17440491; PMCID: PMC2664093.
      View in: PubMed   Mentions: 123     Fields:    Translation:Animals
    258. Autoantibody response to microsomal epoxide hydrolase in hepatitis C and A. J Autoimmun. 2007 Feb; 28(1):7-18. Akatsuka T, Kobayashi N, Ishikawa T, Saito T, Shindo M, Yamauchi M, Kurokohchi K, Miyazawa H, Duan H, Matsunaga T, Komoda T, Morisseau C, Hammock BD. PMID: 17296285; PMCID: PMC1892246.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    259. Measurement of soluble epoxide hydrolase (sEH) activity. Curr Protoc Toxicol. 2007; Chapter 4:Unit 4.23. Morisseau C, Hammock BD. PMID: 23045145.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    260. Prevention of hypertension in DOCA-salt rats by an inhibitor of soluble epoxide hydrolase. Cell Biochem Biophys. 2007; 47(1):87-98. Loch D, Hoey A, Morisseau C, Hammock BO, Brown L. PMID: 17406062; PMCID: PMC1892223.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    261. Effect of ionic liquids on epoxide hydrolase-catalyzed synthesis of chiral 1,2-diols. Green Chem. 2007; 2007(9):162-168. Chiappe C, Leandri E, Hammock BD, Morisseau C. PMID: 18160974; PMCID: PMC2153531.
      View in: PubMed   Mentions: 3  
    262. Compensatory mechanism for homeostatic blood pressure regulation in Ephx2 gene-disrupted mice. J Biol Chem. 2007 Feb 02; 282(5):2891-8. Luria A, Weldon SM, Kabcenell AK, Ingraham RH, Matera D, Jiang H, Gill R, Morisseau C, Newman JW, Hammock BD. PMID: 17135253; PMCID: PMC2040337.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimals
    263. Peptidyl-urea based inhibitors of soluble epoxide hydrolases. Bioorg Med Chem Lett. 2006 Oct 15; 16(20):5439-44. Morisseau C, Newman JW, Tsai HJ, Baecker PA, Hammock BD. PMID: 16908134; PMCID: PMC1892215.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    264. Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase. Bioorg Med Chem. 2007 Jan 01; 15(1):312-23. Kim IH, Nishi K, Tsai HJ, Bradford T, Koda Y, Watanabe T, Morisseau C, Blanchfield J, Toth I, Hammock BD. PMID: 17046265; PMCID: PMC2040326.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    265. Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett. 2006 Nov 15; 16(22):5773-7. Hwang SH, Morisseau C, Do Z, Hammock BD. PMID: 16949285; PMCID: PMC1904340.
      View in: PubMed   Mentions: 17     Fields:    
    266. Inhibition of smooth muscle proliferation by urea-based alkanoic acids via peroxisome proliferator-activated receptor alpha-dependent repression of cyclin D1. Arterioscler Thromb Vasc Biol. 2006 Nov; 26(11):2462-8. Ng VY, Morisseau C, Falck JR, Hammock BD, Kroetz DL. PMID: 16917105; PMCID: PMC1904341.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    267. Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett. 2006 Oct 01; 16(19):5212-6. Jones PD, Tsai HJ, Do ZN, Morisseau C, Hammock BD. PMID: 16870439; PMCID: PMC1904344.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    268. Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs). Prostaglandins Other Lipid Mediat. 2007 Jan; 82(1-4):42-9. Inceoglu B, Schmelzer KR, Morisseau C, Jinks SL, Hammock BD. PMID: 17164131; PMCID: PMC1904338.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansCells
    269. The 5-substituted piperazine as a novel secondary pharmacophore greatly improving the physical properties of urea-based inhibitors of soluble epoxide hydrolase. Bioorg Med Chem. 2006 Oct 01; 14(19):6586-92. Li HY, Jin Y, Morisseau C, Hammock BD, Long YQ. PMID: 16784862; PMCID: PMC2040075.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    270. Substituted adamantyl-urea inhibitors of the soluble epoxide hydrolase dilate mesenteric resistance vessels. J Pharmacol Exp Ther. 2006 Sep; 318(3):1307-14. Olearczyk JJ, Field MB, Kim IH, Morisseau C, Hammock BD, Imig JD. PMID: 16772540.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    271. Development of a high-throughput screen for soluble epoxide hydrolase inhibition. Anal Biochem. 2006 Aug 01; 355(1):71-80. Wolf NM, Morisseau C, Jones PD, Hock B, Hammock BD. PMID: 16729954; PMCID: PMC1964503.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    272. High-throughput pharmacokinetic method: cassette dosing in mice associated with minuscule serial bleedings and LC/MS/MS analysis. Anal Chim Acta. 2006 Feb 10; 559(1):37-44. Watanabe T, Schulz D, Morisseau C, Hammock BD. PMID: 16636700; PMCID: PMC1447531.
      View in: PubMed   Mentions: 26     Fields:    
    273. Characterization of pyrethroid hydrolysis by the human liver carboxylesterases hCE-1 and hCE-2. Arch Biochem Biophys. 2006 Jan 01; 445(1):115-23. Nishi K, Huang H, Kamita SG, Kim IH, Morisseau C, Hammock BD. PMID: 16359636; PMCID: PMC1444892.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    274. Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids. Protein Sci. 2006 Jan; 15(1):58-64. Gomez GA, Morisseau C, Hammock BD, Christianson DW. PMID: 16322563; PMCID: PMC1762130.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    275. The antiinflammatory effect of laminar flow: the role of PPARgamma, epoxyeicosatrienoic acids, and soluble epoxide hydrolase. Proc Natl Acad Sci U S A. 2005 Nov 15; 102(46):16747-52. Liu Y, Zhang Y, Schmelzer K, Lee TS, Fang X, Zhu Y, Spector AA, Gill S, Morisseau C, Hammock BD, Shyy JY. PMID: 16267130; PMCID: PMC1276614.
      View in: PubMed   Mentions: 139     Fields:    Translation:AnimalsCells
    276. Attenuation of vascular smooth muscle cell proliferation by 1-cyclohexyl-3-dodecyl urea is independent of soluble epoxide hydrolase inhibition. J Pharmacol Exp Ther. 2006 Feb; 316(2):815-21. Davis BB, Morisseau C, Newman JW, Pedersen TL, Hammock BD, Weiss RH. PMID: 16221742.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    277. Lipid sulfates and sulfonates are allosteric competitive inhibitors of the N-terminal phosphatase activity of the mammalian soluble epoxide hydrolase. Biochemistry. 2005 Sep 13; 44(36):12179-87. Tran KL, Aronov PA, Tanaka H, Newman JW, Hammock BD, Morisseau C. PMID: 16142916; PMCID: PMC1473036.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    278. Fluorescent substrates for soluble epoxide hydrolase and application to inhibition studies. Anal Biochem. 2005 Aug 01; 343(1):66-75. Jones PD, Wolf NM, Morisseau C, Whetstone P, Hock B, Hammock BD. PMID: 15963942; PMCID: PMC1447601.
      View in: PubMed   Mentions: 94     Fields:    
    279. Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem. 2005 May 19; 48(10):3621-9. Kim IH, Heirtzler FR, Morisseau C, Nishi K, Tsai HJ, Hammock BD. PMID: 15887969; PMCID: PMC1450255.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
    280. Epoxide hydrolases: their roles and interactions with lipid metabolism. Prog Lipid Res. 2005 Jan; 44(1):1-51. Newman JW, Morisseau C, Hammock BD. PMID: 15748653.
      View in: PubMed   Mentions: 191     Fields:    Translation:Animals
    281. Novel mechanism of brain soluble epoxide hydrolase-mediated blood pressure regulation in the spontaneously hypertensive rat. FASEB J. 2005 Apr; 19(6):626-8. Sellers KW, Sun C, Diez-Freire C, Waki H, Morisseau C, Falck JR, Hammock BD, Paton JF, Raizada MK. PMID: 15659536.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    282. Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles. Annu Rev Pharmacol Toxicol. 2005; 45:311-33. Morisseau C, Hammock BD. PMID: 15822179.
      View in: PubMed   Mentions: 185     Fields:    Translation:HumansAnimals
    283. Identification and characterization of an ovary-selective isoform of epoxide hydrolase. Biol Reprod. 2005 Apr; 72(4):968-75. Hennebold JD, Mah K, Perez W, Vance JE, Stouffer RL, Morisseau C, Hammock BD, Adashi EY. PMID: 15601917.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    284. Investigation of the role of a second conserved serine in carboxylesterases via site-directed mutagenesis. Arch Biochem Biophys. 2004 Oct 15; 430(2):247-55. Stok JE, Goloshchapov A, Song C, Wheelock CE, Derbel MB, Morisseau C, Hammock BD. PMID: 15369824.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    285. Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes. J Biol Chem. 2004 Jul 09; 279(28):29863-9. Stok JE, Huang H, Jones PD, Wheelock CE, Morisseau C, Hammock BD. PMID: 15123619.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    286. Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis. Biochemistry. 2004 Apr 27; 43(16):4716-23. Gomez GA, Morisseau C, Hammock BD, Christianson DW. PMID: 15096040.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    287. Design, synthesis, and biological activity of 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility. J Med Chem. 2004 Apr 08; 47(8):2110-22. Kim IH, Morisseau C, Watanabe T, Hammock BD. PMID: 15056008.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimals
    288. Isolation of a strain of Agrobacterium tumefaciens (Rhizobium radiobacter) utilizing methylene urea (ureaformaldehyde) as nitrogen source. Can J Microbiol. 2004 Mar; 50(3):167-74. Koivunen ME, Morisseau C, Horwath WR, Hammock BD. PMID: 15105883.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCellsPHPublic Health
    289. Epoxide hydrolases in the rat epididymis: possible roles in xenobiotic and endogenous fatty acid metabolism. Toxicol Sci. 2004 Apr; 78(2):187-95. DuTeaux SB, Newman JW, Morisseau C, Fairbairn EA, Jelks K, Hammock BD, Miller MG. PMID: 14737000.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    290. Vascular localization of soluble epoxide hydrolase in the human kidney. Am J Physiol Renal Physiol. 2004 Apr; 286(4):F720-6. Yu Z, Davis BB, Morisseau C, Hammock BD, Olson JL, Kroetz DL, Weiss RH. PMID: 14665429.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    291. In vitro metabolism of the mammalian soluble epoxide hydrolase inhibitor, 1-cyclohexyl-3-dodecyl-urea. Drug Metab Dispos. 2003 Jul; 31(7):846-53. Watanabe T, Morisseau C, Newman JW, Hammock BD. PMID: 12814960.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    292. Evaluation of alpha-cyanoesters as fluorescent substrates for examining interindividual variation in general and pyrethroid-selective esterases in human liver microsomes. Anal Biochem. 2003 Apr 15; 315(2):208-22. Wheelock CE, Wheelock AM, Zhang R, Stok JE, Morisseau C, Le Valley SE, Green CE, Hammock BD. PMID: 12689831.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    293. QSAR and classification of murine and human soluble epoxide hydrolase inhibition by urea-like compounds. J Med Chem. 2003 Mar 13; 46(6):1066-80. McElroy NR, Jurs PC, Morisseau C, Hammock BD. PMID: 12620084.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    294. The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1558-63. Newman JW, Morisseau C, Harris TR, Hammock BD. PMID: 12574510; PMCID: PMC149871.
      View in: PubMed   Mentions: 102     Fields:    Translation:Humans
    295. Urea and amide-based inhibitors of the juvenile hormone epoxide hydrolase of the tobacco hornworm (Manduca sexta: Sphingidae). Insect Biochem Mol Biol. 2002 Dec; 32(12):1741-56. Severson TF, Goodrow MH, Morisseau C, Dowdy DL, Hammock BD. PMID: 12429126.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    296. Polymorphism in soluble epoxide hydrolase and blood pressure in spontaneously hypertensive rats. Hypertension. 2002 Oct; 40(4):485-90. Fornage M, Hinojos CA, Nurowska BW, Boerwinkle E, Hammock BD, Morisseau CH, Doris PA. PMID: 12364351.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    297. Human coronary endothelial cells convert 14,15-EET to a biologically active chain-shortened epoxide. Am J Physiol Heart Circ Physiol. 2002 Dec; 283(6):H2306-14. Fang X, Weintraub NL, Oltman CL, Stoll LL, Kaduce TL, Harmon S, Dellsperger KC, Morisseau C, Hammock BD, Spector AA. PMID: 12388281.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    298. Structural refinement of inhibitors of urea-based soluble epoxide hydrolases. Biochem Pharmacol. 2002 May 01; 63(9):1599-608. Morisseau C, Goodrow MH, Newman JW, Wheelock CE, Dowdy DL, Hammock BD. PMID: 12007563.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansAnimalsCells
    299. Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2222-7. Davis BB, Thompson DA, Howard LL, Morisseau C, Hammock BD, Weiss RH. PMID: 11842228; PMCID: PMC122346.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    300. Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension. Hypertension. 2002 Feb; 39(2 Pt 2):690-4. Imig JD, Zhao X, Capdevila JH, Morisseau C, Hammock BD. PMID: 11882632.
      View in: PubMed   Mentions: 177     Fields:    Translation:Animals
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