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Isaac N Pessah, PhD; MS

Title(s)Professor, School of Veterinary Medicine
SchoolUniversity of California, Davis
Address2203 VM3B
CA 95616
Phone530-752-6696
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Dietary caffeine synergizes adverse peripheral and central responses to anesthesia in malignant hyperthermia susceptible mice. Mol Pharmacol. 2020 Aug 06. Aleman M, Zhang R, Feng W, Qi L, Lopez J, Crowe C, Dong Y, Cherednichenko G, Pessah IN. PMID: 32764093.
      View in: PubMed   Mentions:    Fields:    
    2. Sex-specific alterations in whole body energetics and voluntary activity in heterozygous R163C malignant hyperthermia-susceptible mice. FASEB J. 2020 Jun; 34(6):8721-8733. Rutkowsky JM, Knotts TA, Allen PD, Pessah IN, Ramsey JJ. PMID: 32367593.
      View in: PubMed   Mentions: 1     Fields:    
    3. Composition of the Intranuclear Inclusions of Fragile X-associated Tremor/Ataxia Syndrome. Acta Neuropathol Commun. 2019 09 03; 7(1):143. Ma L, Herren AW, Espinal G, Randol J, McLaughlin B, Martinez-Cerdeño V, Pessah IN, Hagerman RJ, Hagerman PJ. PMID: 31481131.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    4. Interactions of Dichlorodiphenyltrichloroethane (DDT) and Dichlorodiphenyldichloroethylene (DDE) With Skeletal Muscle Ryanodine Receptor Type 1. Toxicol Sci. 2019 08 01; 170(2):509-524. Truong KM, Cherednichenko G, Pessah IN. PMID: 31127943.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Developmental exposure to polychlorinated biphenyls (PCBs) in the maternal diet causes host-microbe defects in weanling offspring mice. Environ Pollut. 2019 Oct; 253:708-721. Rude KM, Pusceddu MM, Keogh CE, Sladek JA, Rabasa G, Miller EN, Sethi S, Keil KP, Pessah IN, Lein PJ, Gareau MG. PMID: 31336350.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    6. Influence of Nanomolar Deltamethrin on the Hallmarks of Primary Cultured Cortical Neuronal Network and the Role of Ryanodine Receptors. Environ Health Perspect. 2019 06; 127(6):67003. Zheng J, Yu Y, Feng W, Li J, Liu J, Zhang C, Dong Y, Pessah IN, Cao Z. PMID: 31166131.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    7. Neurotoxicity of polychlorinated biphenyls and related organohalogens. Acta Neuropathol. 2019 09; 138(3):363-387. Pessah IN, Lein PJ, Seegal RF, Sagiv SK. PMID: 30976975.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    8. Comparative Analyses of the 12 Most Abundant PCB Congeners Detected in Human Maternal Serum for Activity at the Thyroid Hormone Receptor and Ryanodine Receptor. Environ Sci Technol. 2019 04 02; 53(7):3948-3958. Sethi S, Morgan RK, Feng W, Lin Y, Li X, Luna C, Koch M, Bansal R, Duffel MW, Puschner B, Zoeller RT, Lehmler HJ, Pessah IN, Lein PJ. PMID: 30821444.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    9. Additional Safety Assessments Needed for Diamide Insecticides. Toxicol Sci. 2019 Mar 04. Pessah IN, Truong K. PMID: 30830166.
      View in: PubMed   Mentions:    Fields:    
    10. Comparison of Chlorantraniliprole and Flubendiamide Activity Toward Wild-Type and Malignant Hyperthermia-Susceptible Ryanodine Receptors and Heat Stress Intolerance. Toxicol Sci. 2019 02 01; 167(2):509-523. Truong KM, Pessah IN. PMID: 30329129.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    11. Saikosaponin d causes apoptotic death of cultured neocortical neurons by increasing membrane permeability and elevating intracellular Ca2+ concentration. Neurotoxicology. 2019 01; 70:112-121. Zheng J, Chen J, Zou X, Zhao F, Guo M, Wang H, Zhang T, Zhang C, Feng W, Pessah IN, Cao Z. PMID: 30458186.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    12. Genetic mutations in Ca2+ signaling alter dendrite morphology and social approach in juvenile mice. Genes Brain Behav. 2019 01; 18(1):e12526. Keil KP, Sethi S, Wilson MD, Silverman JL, Pessah IN, Lein PJ. PMID: 30311737.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    13. A Prospective Study of Environmental Exposures and Early Biomarkers in Autism Spectrum Disorder: Design, Protocols, and Preliminary Data from the MARBLES Study. Environ Health Perspect. 2018 11; 126(11):117004. Hertz-Picciotto I, Schmidt RJ, Walker CK, Bennett DH, Oliver M, Shedd-Wise KM, LaSalle JM, Giulivi C, Puschner B, Thomas J, Roa DL, Pessah IN, Van de Water J, Tancredi DJ, Ozonoff S. PMID: 30465702.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansPHPublic Health
    14. Correction to Organohalogens Naturally Biosynthesized in Marine Environments and Produced As Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca2+ Dynamics. Environ Sci Technol. 2018 Jul 03; 52(13):7594. Zheng J, McKinnie SMK, El Gamal A, Feng W, Dong Y, Agarwal V, Fenical W, Kumar A, Cao Z, Moore BS, Pessah IN. PMID: 29916692.
      View in: PubMed   Mentions:    Fields:    
    15. Organohalogens Naturally Biosynthesized in Marine Environments and Produced as Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca2+ Dynamics. Environ Sci Technol. 2018 05 01; 52(9):5469-5478. Zheng J, McKinnie SMK, El Gamal A, Feng W, Dong Y, Agarwal V, Fenical W, Kumar A, Cao Z, Moore BS, Pessah IN. PMID: 29617551.
      View in: PubMed   Mentions: 3     Fields:    Translation:PHPublic Health
    16. Authentication of synthetic environmental contaminants and their (bio)transformation products in toxicology: polychlorinated biphenyls as an example. Environ Sci Pollut Res Int. 2018 Jun; 25(17):16508-16521. Li X, Holland EB, Feng W, Zheng J, Dong Y, Pessah IN, Duffel MW, Robertson LW, Lehmler HJ. PMID: 29322390.
      View in: PubMed   Mentions: 2     Fields:    Translation:PHPublic Health
    17. Enantioselectivity of 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) Atropisomers toward Ryanodine Receptors (RyRs) and Their Influences on Hippocampal Neuronal Networks. Environ Sci Technol. 2017 Dec 19; 51(24):14406-14416. Feng W, Zheng J, Robin G, Dong Y, Ichikawa M, Inoue Y, Mori T, Nakano T, Pessah IN. PMID: 29131945.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    18. Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): A phylogenetic and population-based comparison. Aquat Toxicol. 2017 Nov; 192:105-115. Holland EB, Goldstone JV, Pessah IN, Whitehead A, Reid NM, Karchner SI, Hahn ME, Nacci DE, Clark BW, Stegeman JJ. PMID: 28942070.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    19. Calcium dysregulation and Cdk5-ATM pathway involved in a mouse model of fragile X-associated tremor/ataxia syndrome. Hum Mol Genet. 2017 07 15; 26(14):2649-2666. Robin G, López JR, Espinal GM, Hulsizer S, Hagerman PJ, Pessah IN. PMID: 28444183.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    20. Development of Tetramethylenedisulfotetramine (TETS) Hapten Library: Synthesis, Electrophysiological Studies, and Immune Response in Rabbits. Chemistry. 2017 Jun 22; 23(35):8466-8472. Barnych B, Vasylieva N, Joseph T, Hulsizer S, Nguyen HM, Cajka T, Pessah I, Wulff H, Gee SJ, Hammock BD. PMID: 28411375.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    21. Rapid Throughput Analysis of GABAA Receptor Subtype Modulators and Blockers Using DiSBAC1(3) Membrane Potential Red Dye. Mol Pharmacol. 2017 07; 92(1):88-99. Nik AM, Pressly B, Singh V, Antrobus S, Hulsizer S, Rogawski MA, Wulff H, Pessah IN. PMID: 28428226.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    22. Divergent Mechanisms Leading to Signaling Dysfunction in Embryonic Muscle by Bisphenol A and Tetrabromobisphenol A. Mol Pharmacol. 2017 04; 91(4):428-436. Zhang R, Pessah IN. PMID: 28143888.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    23. Cumulative Impact of Polychlorinated Biphenyl and Large Chromosomal Duplications on DNA Methylation, Chromatin, and Expression of Autism Candidate Genes. Cell Rep. 2016 12 13; 17(11):3035-3048. Dunaway KW, Islam MS, Coulson RL, Lopez SJ, Vogel Ciernia A, Chu RG, Yasui DH, Pessah IN, Lott P, Mordaunt C, Meguro-Horike M, Horike SI, Korf I, LaSalle JM. PMID: 27974215.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    24. Influence of tetramethylenedisulfotetramine on synchronous calcium oscillations at distinct developmental stages of hippocampal neuronal cultures. Neurotoxicology. 2017 01; 58:11-22. Cao Z, Xu J, Hulsizer S, Cui Y, Dong Y, Pessah IN. PMID: 27984050.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    25. An Extended Structure-Activity Relationship of Nondioxin-Like PCBs Evaluates and Supports Modeling Predictions and Identifies Picomolar Potency of PCB 202 Towards Ryanodine Receptors. Toxicol Sci. 2017 01; 155(1):170-181. Holland EB, Feng W, Zheng J, Dong Y, Li X, Lehmler HJ, Pessah IN. PMID: 27655348.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    26. Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents. Ann N Y Acad Sci. 2016 08; 1378(1):124-136. Pessah IN, Rogawski MA, Tancredi DJ, Wulff H, Zolkowska D, Bruun DA, Hammock BD, Lein PJ. PMID: 27467073.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    27. In cellulo phosphorylation induces pharmacological reprogramming of maurocalcin, a cell-penetrating venom peptide. Proc Natl Acad Sci U S A. 2016 Apr 26; 113(17):E2460-8. Ronjat M, Feng W, Dardevet L, Dong Y, Al Khoury S, Chatelain FC, Vialla V, Chahboun S, Lesage F, Darbon H, Pessah IN, De Waard M. PMID: 27071086.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    28. Detection of the Antimicrobial Triclosan in Environmental Samples by Immunoassay. Environ Sci Technol. 2016 Apr 05; 50(7):3754-61. Ahn KC, Ranganathan A, Bever CS, Hwang SH, Holland EB, Morisseau K, Pessah IN, Hammock BD, Gee SJ. PMID: 26937944.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    29. Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures. Neuropharmacology. 2015 Aug; 95:332-42. Bruun DA, Cao Z, Inceoglu B, Vito ST, Austin AT, Hulsizer S, Hammock BD, Tancredi DJ, Rogawski MA, Pessah IN, Lein PJ. PMID: 25882826.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    30. Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture. Mol Pharmacol. 2015 Apr; 87(4):595-605. Cao Z, Zou X, Cui Y, Hulsizer S, Lein PJ, Wulff H, Pessah IN. PMID: 25583085.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    31. The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant. Neurotherapeutics. 2015 Jan; 12(1):234-49. Coleman N, Nguyen HM, Cao Z, Brown BM, Jenkins DP, Zolkowska D, Chen YJ, Tanaka BS, Goldin AL, Rogawski MA, Pessah IN, Wulff H. PMID: 25256961.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    32. Expression and function of ryanodine receptor related pathways in PCB tolerant Atlantic killifish (Fundulus heteroclitus) from New Bedford Harbor, MA, USA. Aquat Toxicol. 2015 Feb; 159:156-66. Fritsch EB, Stegeman JJ, Goldstone JV, Nacci DE, Champlin D, Jayaraman S, Connon RE, Pessah IN. PMID: 25546006.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    33. Mouse models of the fragile X premutation and fragile X-associated tremor/ataxia syndrome. J Neurodev Disord. 2014; 6(1):25. Berman RF, Buijsen RA, Usdin K, Pintado E, Kooy F, Pretto D, Pessah IN, Nelson DL, Zalewski Z, Charlet-Bergeurand N, Willemsen R, Hukema RK. PMID: 25136376.
      View in: PubMed   Mentions: 19     Fields:    
    34. Ca2+ influx via the Na+/Ca2+ exchanger is enhanced in malignant hyperthermia skeletal muscle. J Biol Chem. 2014 Jul 04; 289(27):19180-90. Altamirano F, Eltit JM, Robin G, Linares N, Ding X, Pessah IN, Allen PD, López JR. PMID: 24847052.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    35. Nanomolar bifenthrin alters synchronous Ca2+ oscillations and cortical neuron development independent of sodium channel activity. Mol Pharmacol. 2014 Apr; 85(4):630-9. Cao Z, Cui Y, Nguyen HM, Jenkins DP, Wulff H, Pessah IN. PMID: 24482397.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    36. PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms. Toxicol Sci. 2014 Apr; 138(2):379-92. Yang D, Kania-Korwel I, Ghogha A, Chen H, Stamou M, Bose DD, Pessah IN, Lehmler HJ, Lein PJ. PMID: 24385416.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    37. Reduced excitatory amino acid transporter 1 and metabotropic glutamate receptor 5 expression in the cerebellum of fragile X mental retardation gene 1 premutation carriers with fragile X-associated tremor/ataxia syndrome. Neurobiol Aging. 2014 May; 35(5):1189-97. Pretto DI, Kumar M, Cao Z, Cunningham CL, Durbin-Johnson B, Qi L, Berman R, Noctor SC, Hagerman RJ, Pessah IN, Tassone F. PMID: 24332449.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    38. Structure-activity relationship of selected meta- and para-hydroxylated non-dioxin like polychlorinated biphenyls: from single RyR1 channels to muscle dysfunction. Toxicol Sci. 2013 Dec; 136(2):500-13. Niknam Y, Feng W, Cherednichenko G, Dong Y, Joshi SN, Vyas SM, Lehmler HJ, Pessah IN. PMID: 24014653.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    39. Aryl hydrocarbon receptor signaling regulates NF-?B RelB activation during dendritic-cell differentiation. Immunol Cell Biol. 2013 Oct; 91(9):568-75. Vogel CF, Wu D, Goth SR, Baek J, Lollies A, Domhardt R, Grindel A, Pessah IN. PMID: 23999131.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    40. Autism-specific maternal autoantibodies recognize critical proteins in developing brain. Transl Psychiatry. 2013 Jul 09; 3:e277. Braunschweig D, Krakowiak P, Duncanson P, Boyce R, Hansen RL, Ashwood P, Hertz-Picciotto I, Pessah IN, Van de Water J. PMID: 23838888.
      View in: PubMed   Mentions: 63     Fields:    Translation:Humans
    41. Structure-activity relationship of non-coplanar polychlorinated biphenyls toward skeletal muscle ryanodine receptors in rainbow trout (Oncorhynchus mykiss). Aquat Toxicol. 2013 Sep 15; 140-141:204-12. Fritsch EB, Pessah IN. PMID: 23827775.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    42. Trophoblast inclusions are significantly increased in the placentas of children in families at risk for autism. Biol Psychiatry. 2013 Aug 01; 74(3):204-11. Walker CK, Anderson KW, Milano KM, Ye S, Tancredi DJ, Pessah IN, Hertz-Picciotto I, Kliman HJ. PMID: 23623455.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    43. Simultaneous determination of polybrominated diphenyl ethers and polychlorinated biphenyls by gas chromatography-tandem mass spectrometry in human serum and plasma. Talanta. 2013 Sep 15; 113:41-8. Lin YP, Pessah IN, Puschner B. PMID: 23708622.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansPHPublic Health
    44. Enhanced asynchronous Ca(2+) oscillations associated with impaired glutamate transport in cortical astrocytes expressing Fmr1 gene premutation expansion. J Biol Chem. 2013 May 10; 288(19):13831-41. Cao Z, Hulsizer S, Cui Y, Pretto DL, Kim KH, Hagerman PJ, Tassone F, Pessah IN. PMID: 23553633.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    45. Global increases in both common and rare copy number load associated with autism. Hum Mol Genet. 2013 Jul 15; 22(14):2870-80. Girirajan S, Johnson RL, Tassone F, Balciuniene J, Katiyar N, Fox K, Baker C, Srikanth A, Yeoh KH, Khoo SJ, Nauth TB, Hansen R, Ritchie M, Hertz-Picciotto I, Eichler EE, Pessah IN, Selleck SB. PMID: 23535821.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    46. Identification of expanded alleles of the FMR1 Gene in the CHildhood Autism Risks from Genes and Environment (CHARGE) study. J Autism Dev Disord. 2013 Mar; 43(3):530-9. Tassone F, Choudhary NS, Tassone F, Durbin-Johnson B, Hansen R, Hertz-Picciotto I, Pessah I. PMID: 22767137.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    47. Triclosan impairs swimming behavior and alters expression of excitation-contraction coupling proteins in fathead minnow (Pimephales promelas). Environ Sci Technol. 2013 Feb 19; 47(4):2008-17. Fritsch EB, Connon RE, Werner I, Davies RE, Beggel S, Feng W, Pessah IN. PMID: 23305567.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    48. Nonspecific sarcolemmal cation channels are critical for the pathogenesis of malignant hyperthermia. FASEB J. 2013 Mar; 27(3):991-1000. Eltit JM, Ding X, Pessah IN, Allen PD, Lopez JR. PMID: 23159934.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    49. Early mitochondrial abnormalities in hippocampal neurons cultured from Fmr1 pre-mutation mouse model. J Neurochem. 2012 Nov; 123(4):613-21. Kaplan ES, Cao Z, Hulsizer S, Tassone F, Berman RF, Hagerman PJ, Pessah IN. PMID: 22924671.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    50. Maternal transfer of BDE-47 to offspring and neurobehavioral development in C57BL/6J mice. Neurotoxicol Teratol. 2012 Nov-Dec; 34(6):571-80. Koenig CM, Lango J, Pessah IN, Berman RF. PMID: 23022914.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    51. Levels of select PCB and PBDE congeners in human postmortem brain reveal possible environmental involvement in 15q11-q13 duplication autism spectrum disorder. Environ Mol Mutagen. 2012 Oct; 53(8):589-98. Mitchell MM, Woods R, Chi LH, Schmidt RJ, Pessah IN, Kostyniak PJ, LaSalle JM. PMID: 22930557.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    52. Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model. J Neuroimmunol. 2012 Nov 15; 252(1-2):56-65. Braunschweig D, Golub MS, Koenig CM, Qi L, Pessah IN, Van de Water J, Berman RF. PMID: 22951357.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    53. Coordinated regulation of murine cardiomyocyte contractility by nanomolar (-)-epigallocatechin-3-gallate, the major green tea catechin. Mol Pharmacol. 2012 Nov; 82(5):993-1000. Feng W, Hwang HS, Kryshtal DO, Yang T, Padilla IT, Tiwary AK, Puschner B, Pessah IN, Knollmann BC. PMID: 22918967.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    54. Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14158-63. Cherednichenko G, Zhang R, Bannister RA, Timofeyev V, Li N, Fritsch EB, Feng W, Barrientos GC, Schebb NH, Hammock BD, Beam KG, Chiamvimonvat N, Pessah IN. PMID: 22891308.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    55. Tetramethylenedisulfotetramine alters Ca²? dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation. Toxicol Sci. 2012 Dec; 130(2):362-72. Cao Z, Hammock BD, McCoy M, Rogawski MA, Lein PJ, Pessah IN. PMID: 22889812.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    56. Behavioral correlates of maternal antibody status among children with autism. J Autism Dev Disord. 2012 Jul; 42(7):1435-45. Braunschweig D, Duncanson P, Boyce R, Hansen R, Ashwood P, Pessah IN, Hertz-Picciotto I, Van de Water J. PMID: 22012245.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    57. Lack of evidence for neonatal misoprostol neurodevelopmental toxicity in C57BL6/J mice. PLoS One. 2012; 7(6):e38911. Koenig CM, Walker CK, Qi L, Pessah IN, Berman RF. PMID: 22719983.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsPHPublic Health
    58. Signaling defects in iPSC-derived fragile X premutation neurons. Hum Mol Genet. 2012 Sep 01; 21(17):3795-805. Liu J, Koscielska KA, Cao Z, Hulsizer S, Grace N, Mitchell G, Nacey C, Githinji J, McGee J, Garcia-Arocena D, Hagerman RJ, Nolta J, Pessah IN, Hagerman PJ. PMID: 22641815.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    59. Malignant hyperthermia susceptibility arising from altered resting coupling between the skeletal muscle L-type Ca2+ channel and the type 1 ryanodine receptor. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7923-8. Eltit JM, Bannister RA, Moua O, Altamirano F, Hopkins PM, Pessah IN, Molinski TF, López JR, Beam KG, Allen PD. PMID: 22547813.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    60. PCB-95 promotes dendritic growth via ryanodine receptor-dependent mechanisms. Environ Health Perspect. 2012 Jul; 120(7):997-1002. Wayman GA, Yang D, Bose DD, Lesiak A, Ledoux V, Bruun D, Pessah IN, Lein PJ. PMID: 22534141.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    61. PCB-95 modulates the calcium-dependent signaling pathway responsible for activity-dependent dendritic growth. Environ Health Perspect. 2012 Jul; 120(7):1003-9. Wayman GA, Bose DD, Yang D, Lesiak A, Bruun D, Impey S, Ledoux V, Pessah IN, Lein PJ. PMID: 22534176.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    62. Tipping the balance of autism risk: potential mechanisms linking pesticides and autism. Environ Health Perspect. 2012 Jul; 120(7):944-51. Shelton JF, Hertz-Picciotto I, Pessah IN. PMID: 22534084.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansPHPublic Health
    63. Clustered burst firing in FMR1 premutation hippocampal neurons: amelioration with allopregnanolone. Hum Mol Genet. 2012 Jul 01; 21(13):2923-35. Cao Z, Hulsizer S, Tassone F, Tang HT, Hagerman RJ, Rogawski MA, Hagerman PJ, Pessah IN. PMID: 22466801.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    64. Long-lived epigenetic interactions between perinatal PBDE exposure and Mecp2308 mutation. Hum Mol Genet. 2012 Jun 01; 21(11):2399-411. Woods R, Vallero RO, Golub MS, Suarez JK, Ta TA, Yasui DH, Chi LH, Kostyniak PJ, Pessah IN, Berman RF, LaSalle JM. PMID: 22343140.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsPHPublic Health
    65. Gene dose influences cellular and calcium channel dysregulation in heterozygous and homozygous T4826I-RYR1 malignant hyperthermia-susceptible muscle. J Biol Chem. 2012 Jan 20; 287(4):2863-76. Barrientos GC, Feng W, Truong K, Matthaei KI, Yang T, Allen PD, Lopez JR, Pessah IN. PMID: 22139840.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    66. Mice expressing T4826I-RYR1 are viable but exhibit sex- and genotype-dependent susceptibility to malignant hyperthermia and muscle damage. FASEB J. 2012 Mar; 26(3):1311-22. Yuen B, Boncompagni S, Feng W, Yang T, Lopez JR, Matthaei KI, Goth SR, Protasi F, Franzini-Armstrong C, Allen PD, Pessah IN. PMID: 22131268.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
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    85. Altered T cell responses in children with autism. Brain Behav Immun. 2011 Jul; 25(5):840-9. Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah IN, Van de Water J. PMID: 20833247.
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    95. Blood mercury concentrations in CHARGE Study children with and without autism. Environ Health Perspect. 2010 Jan; 118(1):161-6. Hertz-Picciotto I, Green PG, Delwiche L, Hansen R, Walker C, Pessah IN. PMID: 20056569.
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    96. Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity. Pharmacol Ther. 2010 Feb; 125(2):260-85. Pessah IN, Cherednichenko G, Lein PJ. PMID: 19931307.
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    112. In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: receptor-based bioassay screens. Environ Health Perspect. 2008 Sep; 116(9):1203-10. Ahn KC, Zhao B, Chen J, Cherednichenko G, Sanmarti E, Denison MS, Lasley B, Pessah IN, Kültz D, Chang DP, Gee SJ, Hammock BD. PMID: 18795164.
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    141. Purkinje cell and cerebellar effects following developmental exposure to PCBs and/or MeHg. Neurotoxicol Teratol. 2006 Jan-Feb; 28(1):74-85. Roegge CS, Morris JR, Villareal S, Wang VC, Powers BE, Klintsova AY, Greenough WT, Pessah IN, Schantz SL. PMID: 16309888.
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    144. Principles and practices of neurodevelopmental assessment in children: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environ Health Perspect. 2005 Oct; 113(10):1437-46. Dietrich KN, Eskenazi B, Schantz S, Yolton K, Rauh VA, Johnson CB, Alkon A, Canfield RL, Pessah IN, Berman RF. PMID: 16203260.
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    145. Formulation and characterization of an experimental PCB mixture designed to mimic human exposure from contaminated fish. Toxicol Sci. 2005 Dec; 88(2):400-11. Kostyniak PJ, Hansen LG, Widholm JJ, Fitzpatrick RD, Olson JR, Helferich JL, Kim KH, Sable HJ, Seegal RF, Pessah IN, Schantz SL. PMID: 16177234.
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    147. Ryanodine receptor-mediated rapid increase in intracellular calcium induced by 7,8-benzo(a)pyrene quinone in human and murine leukocytes. Toxicol Sci. 2005 Oct; 87(2):419-26. Gao J, Voss AA, Pessah IN, Lauer FT, Penning TM, Burchiel SW. PMID: 16049270.
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    148. Three structurally related, highly potent, peptides from the venom of Parabuthus transvaalicus possess divergent biological activity. Toxicon. 2005 May; 45(6):727-33. Inceoglu B, Lango J, Pessah IN, Hammock BD. PMID: 15804521.
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    150. 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas). Antagonists of the RyR1-FKBP12 Ca2+ Channel. Marine Drugs. 2004 Nov 25; 2(4):176-184. Makoto N. Masuno, Alexander C. Hoepker, Isaac N. Pessah, Tadeusz F. Molinski. .
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    151. Enhanced response to caffeine and 4-chloro-m-cresol in malignant hyperthermia-susceptible muscle is related in part to chronically elevated resting [Ca2+]i. Am J Physiol Cell Physiol. 2005 Mar; 288(3):C606-12. López JR, Linares N, Pessah IN, Allen PD. PMID: 15537710.
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    152. Conformational activation of Ca2+ entry by depolarization of skeletal myotubes. Proc Natl Acad Sci U S A. 2004 Nov 02; 101(44):15793-8. Cherednichenko G, Hurne AM, Fessenden JD, Lee EH, Allen PD, Beam KG, Pessah IN. PMID: 15505226.
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    153. Mutational analysis of putative calcium binding motifs within the skeletal ryanodine receptor isoform, RyR1. J Biol Chem. 2004 Dec 17; 279(51):53028-35. Fessenden JD, Feng W, Pessah IN, Allen PD. PMID: 15469935.
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    154. Association of a mutation in the ryanodine receptor 1 gene with equine malignant hyperthermia. Muscle Nerve. 2004 Sep; 30(3):356-65. Aleman M, Riehl J, Aldridge BM, Lecouteur RA, Stott JL, Pessah IN. PMID: 15318347.
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    155. Evidence for conformational coupling between two calcium channels. Proc Natl Acad Sci U S A. 2004 Aug 24; 101(34):12748-52. Paolini C, Fessenden JD, Pessah IN, Franzini-Armstrong C. PMID: 15310845.
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    156. Identification of hyperreactive cysteines within ryanodine receptor type 1 by mass spectrometry. J Biol Chem. 2004 Aug 13; 279(33):34514-20. Voss AA, Lango J, Ernst-Russell M, Morin D, Pessah IN. PMID: 15197184.
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    157. NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release. Circ Res. 2004 Mar 05; 94(4):478-86. Cherednichenko G, Zima AV, Feng W, Schaefer S, Blatter LA, Pessah IN. PMID: 14699012.
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    158. Homer protein increases activation of Ca2+ sparks in permeabilized skeletal muscle. J Biol Chem. 2004 Feb 13; 279(7):5781-7. Ward CW, Feng W, Tu J, Pessah IN, Worley PK, Schneider MF. PMID: 14660561.
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    159. Non-coplanar 2,2',3,5',6-pentachlorobiphenyl (PCB 95) amplifies ionotropic glutamate receptor signaling in embryonic cerebellar granule neurons by a mechanism involving ryanodine receptors. Toxicol Sci. 2004 Jan; 77(1):72-82. Gafni J, Wong PW, Pessah IN. PMID: 14600284.
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    162. Polychlorinated biphenyls induce caspase-dependent cell death in cultured embryonic rat hippocampal but not cortical neurons via activation of the ryanodine receptor. Toxicol Appl Pharmacol. 2003 Jul 01; 190(1):72-86. Howard AS, Fitzpatrick R, Pessah I, Kostyniak P, Lein PJ. PMID: 12831785.
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    163. Identification of a key determinant of ryanodine receptor type 1 required for activation by 4-chloro-m-cresol. J Biol Chem. 2003 Aug 01; 278(31):28727-35. Fessenden JD, Perez CF, Goth S, Pessah IN, Allen PD. PMID: 12761215.
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    165. RyR1/RyR3 chimeras reveal that multiple domains of RyR1 are involved in skeletal-type E-C coupling. Biophys J. 2003 Apr; 84(4):2655-63. Perez CF, Voss A, Pessah IN, Allen PD. PMID: 12668474.
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    167. One scorpion, two venoms: prevenom of Parabuthus transvaalicus acts as an alternative type of venom with distinct mechanism of action. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):922-7. Inceoglu B, Lango J, Jing J, Chen L, Doymaz F, Pessah IN, Hammock BD. PMID: 12552107.
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    171. (+)-7S-Hydroxyxestospongin A from the marine sponge Xestospongia sp. and absolute configuration of (+)-xestospongin D. J Nat Prod. 2002 Mar; 65(3):249-54. Moon SS, MacMillan JB, Olmstead MM, Ta TA, Pessah IN, Molinski TF. PMID: 11908959.
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    177. A bioactive metabolite of benzo[a]pyrene, benzo[a]pyrene-7,8-dione, selectively alters microsomal Ca2+ transport and ryanodine receptor function. Mol Pharmacol. 2001 Mar; 59(3):506-13. Pessah IN, Beltzner C, Burchiel SW, Sridhar G, Penning T, Feng W. PMID: 11179446.
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    179. ortho-substituted PCB95 alters intracellular calcium signaling and causes cellular acidification in PC12 cells by an immunophilin-dependent mechanism. J Neurochem. 2001 Jan; 76(2):450-63. Wong PW, Garcia EF, Pessah IN. PMID: 11208908.
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    180. Transmembrane redox sensor of ryanodine receptor complex. J Biol Chem. 2000 Nov 17; 275(46):35902-7. Feng W, Liu G, Allen PD, Pessah IN. PMID: 10998414.
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    182. Role of the sarcoplasmic reticulum in regulating the activity-dependent expression of the glycogen phosphorylase gene in contractile skeletal muscle cells. J Cell Physiol. 2000 Nov; 185(2):184-99. Vali S, Carlsen R, Pessah I, Gorin F. PMID: 11025440.
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    190. Mechanisms of delta-hexachlorocyclohexane toxicity: I. Relationship between altered ventricular myocyte contractility and ryanodine receptor function. J Pharmacol Exp Ther. 1999 Apr; 289(1):477-85. Buck ED, Lachnit WG, Pessah IN. PMID: 10087040.
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    192. Functional interaction between InsP3 receptors and store-operated Htrp3 channels. Nature. 1998 Dec 03; 396(6710):478-82. Kiselyov K, Xu X, Mozhayeva G, Kuo T, Pessah I, Mignery G, Zhu X, Birnbaumer L, Muallem S. PMID: 9853757.
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    193. Inositol-1,4,5-trisphosphate receptor-mediated Ca mobilization is not required for cerebellar long-term depression in reduced preparations. J Neurophysiol. 1998 Dec; 80(6):2963-74. Narasimhan K, Pessah IN, Linden DJ. PMID: 9862899.
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    198. Ortho-substituted polychlorinated biphenyls alter microsomal calcium transport by direct interaction with ryanodine receptors of mammalian brain. J Biol Chem. 1997 Jun 13; 272(24):15145-53. Wong PW, Brackney WR, Pessah IN. PMID: 9182535.
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    199. Noncoplanar PCB 95 alters microsomal calcium transport by an immunophilin FKBP12-dependent mechanism. Mol Pharmacol. 1997 May; 51(5):693-702. Wong PW, Pessah IN. PMID: 9145907.
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    200. Dyspedic mouse skeletal muscle expresses major elements of the triadic junction but lacks detectable ryanodine receptor protein and function. J Biol Chem. 1997 Mar 14; 272(11):7360-7. Buck ED, Nguyen HT, Pessah IN, Allen PD. PMID: 9054435.
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    208. The delta isomer of hexachlorocyclohexane induces rapid release of the myo-inositol-1,4,5-trisphosphate-sensitive Ca2+ store and blocks capacitative Ca2+ entry in rat basophilic leukemia cells. Mol Pharmacol. 1995 Sep; 48(3):512-22. Mohr FC, Alojipan SV, Dunston SK, Pessah IN. PMID: 7565633.
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    209. Iron(II) is a modulator of ryanodine-sensitive calcium channels of cardiac muscle sarcoplasmic reticulum. Toxicol Appl Pharmacol. 1995 Jan; 130(1):57-66. Kim E, Giri SN, Pessah IN. PMID: 7530865.
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    213. Antithetical actions of mitoxantrone and doxorubicin on ryanodine-sensitive Ca++ release channels of rat cardiac sarcoplasmic reticulum: evidence for a competitive mechanism. J Pharmacol Exp Ther. 1994 Mar; 268(3):1212-21. Kim E, Giri SN, Pessah IN. PMID: 8138934.
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    215. Regulation of inositol 1,4,5-trisphosphate receptors in rat basophilic leukemia cells. I. Multiple conformational states of the receptor in a microsomal preparation. Biochim Biophys Acta. 1993 Apr 08; 1147(1):105-14. Mohr FC, Hershey PE, Zimányi I, Pessah IN. PMID: 8385492.
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    216. Regulation of inositol 1,4,5-trisphosphate receptors in rat basophilic leukemia cells. II. Modulation of the receptor in permeabilized cells by the cytosolic compartment. Biochim Biophys Acta. 1993 Apr 08; 1147(1):115-24. Hershey PE, Pessah IN, Mohr FC. PMID: 8385493.
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    217. Porphyrin induced calcium release from skeletal muscle sarcoplasmic reticulum. Arch Biochem Biophys. 1993 Mar; 301(2):396-403. Abramson JJ, Milne S, Buck E, Pessah IN. PMID: 7681662.
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    218. Prolonged exercise reduces Ca2+ release in rat skeletal muscle sarcoplasmic reticulum. Pflugers Arch. 1993 Feb; 422(5):472-5. Favero TG, Pessah IN, Klug GA. PMID: 7682687.
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    219. Ryanodine induces maturation of embryonic acetylcholinesterase forms in cultured quail myotubes. Life Sci. 1993; 52(15):1279-85. Pessah IN, Nieberg PS, Wilson BW. PMID: 7681926.
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    220. Ryanodine induces persistent inactivation of the Ca2+ release channel from skeletal muscle sarcoplasmic reticulum. Mol Pharmacol. 1992 Dec; 42(6):1049-57. Zimányi I, Buck E, Abramson JJ, Mack MM, Pessah IN. PMID: 1480132.
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    221. Ryanodine stabilizes multiple conformational states of the skeletal muscle calcium release channel. J Biol Chem. 1992 Nov 25; 267(33):23560-7. Buck E, Zimanyi I, Abramson JJ, Pessah IN. PMID: 1331089.
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    222. Discrimination of multiple binding sites for antagonists of the calcium release channel complex of skeletal and cardiac sarcoplasmic reticulum. J Pharmacol Exp Ther. 1992 Sep; 262(3):1028-37. Mack WM, Zimányi I, Pessah IN. PMID: 1382127.
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    223. Stereoselective modulation of ryanodine-sensitive calcium channels by the delta isomer of hexachlorocyclohexane (delta-HCH). J Pharmacol Exp Ther. 1992 Aug; 262(2):661-9. Pessah IN, Mohr FC, Schiedt M, Joy RM. PMID: 1380081.
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    224. Photooxidation of skeletal muscle sarcoplasmic reticulum induces rapid calcium release. Arch Biochem Biophys. 1992 Feb 01; 292(2):512-21. Stuart J, Pessah IN, Favero TG, Abramson JJ. PMID: 1531000.
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    225. Rose bengal activates the Ca2+ release channel from skeletal muscle sarcoplasmic reticulum. Arch Biochem Biophys. 1992 Feb 01; 292(2):522-8. Xiong H, Buck E, Stuart J, Pessah IN, Salama G, Abramson JJ. PMID: 1309975.
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    226. Etiology of sarcoplasmic reticulum calcium release channel lesions in doxorubicin-induced cardiomyopathy. Toxicology. 1992; 72(2):189-206. Pessah IN, Schiedt MJ, Shalaby MA, Mack M, Giri SN. PMID: 1314436.
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    227. Calcium release channel of sarcoplasmic reticulum: an important target for doxorubicin-mediated cardiotoxicity. Adv Exp Med Biol. 1992; 311:409-10. Pessah IN. PMID: 1326869.
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    228. Pharmacological characterization of the specific binding of [3H]ryanodine to rat brain microsomal membranes. Brain Res. 1991 Oct 11; 561(2):181-91. Zimanyi I, Pessah IN. PMID: 1666327.
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    229. Characterization of multiple [3H]ryanodine binding sites on the Ca2+ release channel of sarcoplasmic reticulum from skeletal and cardiac muscle: evidence for a sequential mechanism in ryanodine action. Mol Pharmacol. 1991 May; 39(5):679-89. Pessah IN, Zimanyi I. PMID: 1851961.
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    230. Comparison of [3H]ryanodine receptors and Ca++ release from rat cardiac and rabbit skeletal muscle sarcoplasmic reticulum. J Pharmacol Exp Ther. 1991 Mar; 256(3):938-46. Zimányi I, Pessah IN. PMID: 1848635.
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    231. Anthraquinone-sensitized Ca2+ release channel from rat cardiac sarcoplasmic reticulum: possible receptor-mediated mechanism of doxorubicin cardiomyopathy. Mol Pharmacol. 1990 Apr; 37(4):503-14. Pessah IN, Durie EL, Schiedt MJ, Zimanyi I. PMID: 2157959.
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    232. Early over-expression of low-affinity [3H]ryanodine receptor sites in heavy sarcoplasmic reticulum fraction from dystrophic chicken pectoralis major. Biochim Biophys Acta. 1990 Mar 30; 1023(1):98-106. Pessah IN, Schiedt MJ. PMID: 2156566.
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    233. Reactive disulfides trigger Ca2+ release from sarcoplasmic reticulum via an oxidation reaction. J Biol Chem. 1989 Dec 25; 264(36):21725-36. Zaidi NF, Lagenaur CF, Abramson JJ, Pessah I, Salama G. PMID: 2532212.
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    234. Mechanism of anthraquinone-induced calcium release from skeletal muscle sarcoplasmic reticulum. J Biol Chem. 1988 Dec 15; 263(35):18750-8. Abramson JJ, Buck E, Salama G, Casida JE, Pessah IN. PMID: 3198599.
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    235. Partial characterization of specific cantharidin binding sites in mouse tissues. Mol Pharmacol. 1988 Jun; 33(6):706-12. Graziano MJ, Pessah IN, Matsuzawa M, Casida JE. PMID: 3380085.
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    236. Structural aspects of ryanodine action and selectivity. J Med Chem. 1987 Apr; 30(4):710-6. Waterhouse AL, Pessah IN, Francini AO, Casida JE. PMID: 2435905.
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    237. Ca2+-activated ryanodine binding: mechanisms of sensitivity and intensity modulation by Mg2+, caffeine, and adenine nucleotides. Mol Pharmacol. 1987 Mar; 31(3):232-8. Pessah IN, Stambuk RA, Casida JE. PMID: 2436032.
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    238. Solubilization and separation of Ca2+-ATPase from the Ca2+-ryanodine receptor complex. Biochem Biophys Res Commun. 1986 Aug 29; 139(1):235-43. Pessah IN, Anderson KW, Casida JE. PMID: 2945551.
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    239. Calcium-ryanodine receptor complex. Solubilization and partial characterization from skeletal muscle junctional sarcoplasmic reticulum vesicles. J Biol Chem. 1986 Jul 05; 261(19):8643-8. Pessah IN, Francini AO, Scales DJ, Waterhouse AL, Casida JE. PMID: 3722165.
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    240. Distribution, pharmacokinetics, and metabolism of [14C]2,4-diamino-6-(2-furyl)-s-triazine in various developmental stages of the house fly. Pesticide Biochemistry and Physiology. 1986 Jun 1; 25(3):306-318. Isaac N. Pessah, Robert E. Menzer, Alexej B. Borkovec. .
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    241. The calcium-ryanodine receptor complex of skeletal and cardiac muscle. Biochem Biophys Res Commun. 1985 Apr 16; 128(1):449-56. Pessah IN, Waterhouse AL, Casida JE. PMID: 3985981.
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    242. The interaction of organophosphate and carbamate insecticides with cholinesterases in the terrestrial pulmonate, Limax maximus. Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology. 1983 Jan 1; 74(2):291-297. Isaac N. Pessah, Phillip G. Sokolove. .
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    243. Determination and characterization of cholinesterases in localized tissues of the giant garden slugs Limax maximus (Linnaeus). Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology. 1983 Jan 1; 74(2):281-289. Isaac N. Pessah, Phillip G. Sokolove. .
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    244. Regulation of [3H]perhydrohistrionicotoxin binding to Torpedo ocellata electroplax by effectors of the acetylcholine receptor. J Biol Chem. 1981 Mar 25; 256(6):2843-50. Aronstam RS, Eldefrawi AT, Pessah IN, Daly JW, Albuquerque EX, Eldefrawi ME. PMID: 7204378.
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    245. Reconstitution of N1-methylnicotinamide and p-aminohippuric acid transport in phospholipid vesicles with a protein fraction isolated from dog kidney membranes. Mol Pharmacol. 1979 Jul; 16(1):343-56. Holohan PD, Pessah NI, Pessah IN, Ross CR. PMID: 39247.
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