Eleonora Napoli

Title(s)Associate Scientist, Neurology
SchoolSchool of Medicine
Address4860 Y Street
CA 95817
Phone(530)752-1038
ORCID ORCID Icon0000-0001-8808-4242 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California Davis, Davis, CAPost Doctoral Fellow2007Neuroscience, Mitochondrial disorders
    University of Padua, Padua, ItalyPh.D.2004Pharmacology and Toxicology
    University of Padua, Padua, ItalyB.S.1998Biological Sciences

    Collapse Overview 
    Collapse Overview
    For the past 20+ years, my research has focused on the role of mitochondrial deficits in neurodegenerative disorders like Fragile X-Tremor/Ataxia Syndrome (FXTAS) and Huntington's disease (HD), but also on the involvement of bioenergetics and metabolic deficits in neurodevelopment disorders like ASD.

    More recently my research focus has shifted towards ATP1A3-related disorders, with the goal of generating a comprehensive natural history of the symptoms and disease progression, as well as epilepsy. In this regard, I am currently involved in a study centered on the investigation of the effects of seizure activity on neurotransmitters modulation, with particular emphasis on the molecular mechanisms underlying regulation of GABA(A) receptor expression during epileptogenesis.

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    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Molecular, Translational and Clinical Research on the Two Most Common Forms of Neurodegenerative Dementia: Alzheimer's Disease and Dementia with Lewy Bodies. Int J Mol Sci. 2023 Apr 28; 24(9). Napoli E. PMID: 37175703; PMCID: PMC10178392.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Selective Neuronal Knockout of STAT3 Function Inhibits Epilepsy Progression, Improves Cognition, and Restores Dysregulated Gene Networks in a Temporal Lobe Epilepsy Model. Ann Neurol. 2023 07; 94(1):106-122. Tipton AE, Cruz Del Angel Y, Hixson K, Carlsen J, Strode D, Busquet N, Mesches MH, Gonzalez MI, Napoli E, Russek SJ, Brooks-Kayal AR. PMID: 36935347; PMCID: PMC10313781.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    3. Brain Atrophy and White Matter Damage Linked to Peripheral Bioenergetic Deficits in the Neurodegenerative Disease FXTAS. Int J Mol Sci. 2021 Aug 25; 22(17). Wang J, Napoli E, Kim K, McLennan YA, Hagerman RJ, Giulivi C. PMID: 34502080; PMCID: PMC8431233.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    4. Wdfy3 regulates glycophagy, mitophagy, and synaptic plasticity. J Cereb Blood Flow Metab. 2021 12; 41(12):3213-3231. Napoli E, Panoutsopoulos AA, Kysar P, Satriya N, Sterling K, Shibata B, Imai D, Ruskin DN, Zarbalis KS, Giulivi C. PMID: 34187232; PMCID: PMC8669292.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    5. Sulforaphane improves mitochondrial metabolism in fibroblasts from patients with fragile X-associated tremor and ataxia syndrome. Neurobiol Dis. 2021 09; 157:105427. Napoli E, Flores A, Mansuri Y, Hagerman RJ, Giulivi C. PMID: 34153466; PMCID: PMC8475276.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    6. Deficits in Prenatal Serine Biosynthesis Underlie the Mitochondrial Dysfunction Associated with the Autism-Linked FMR1 Gene. Int J Mol Sci. 2021; 22(11):5886. Nolin S, Napoli E, Flores A, Hagerman RJ, Giulivi C. View Publication.
    7. Characterization of the Metabolic, Clinical and Neuropsychological Phenotype of Female Carriers of the Premutation in the X-Linked FMR1 Gene. Front Mol Biosci. 2020; 7:578640. Napoli E, McLennan YA, Schneider A, Tassone F, Hagerman RJ, Giulivi C. PMID: 33195422; PMCID: PMC7642626.
      View in: PubMed   Mentions: 8  
    8. mtDNA depletion-like syndrome in Wilson disease. Liver Int. 2020 11; 40(11):2776-2787. Medici V, Sarode GV, Napoli E, Song GY, Shibata NM, Guimarães AO, Mordaunt CE, Kieffer DA, Mazi TA, Czlonkowska A, Litwin T, LaSalle JM, Giulivi C. PMID: 32996699; PMCID: PMC8079140.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    9. Forensic determination of hair deposition time in crime scenes using electron paramagnetic resonance. J Forensic Sci. 2021 Jan; 66(1):72-82. Shankar N, Guimarães AO, Napoli E, Giulivi C. PMID: 32986869.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. PPARα-targeted mitochondrial bioenergetics mediate repair of intestinal barriers at the host-microbe intersection during SIV infection. Proc Natl Acad Sci U S A. 2019 12 03; 116(49):24819-24829. Crakes KR, Santos Rocha C, Grishina I, Hirao LA, Napoli E, Gaulke CA, Fenton A, Datta S, Arredondo J, Marco ML, Sankaran-Walters S, Cortopassi G, Giulivi C, Dandekar S. PMID: 31740620; PMCID: PMC6900595.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    11. Potential biomarker identification for Friedreich's ataxia using overlapping gene expression patterns in patient cells and mouse dorsal root ganglion. PLoS One. 2019; 14(10):e0223209. McMackin MZ, Durbin-Johnson B, Napierala M, Napierala JS, Ruiz L, Napoli E, Perlman S, Giulivi C, Cortopassi GA. PMID: 31665133; PMCID: PMC6821053.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    12. Pathogenic WDFY3 variants cause neurodevelopmental disorders and opposing effects on brain size. Brain. 2019 09 01; 142(9):2617-2630. Le Duc D, Giulivi C, Hiatt SM, Napoli E, Panoutsopoulos A, Harlan De Crescenzo A, Kotzaeridou U, Syrbe S, Anagnostou E, Azage M, Bend R, Begtrup A, Brown NJ, Büttner B, Cho MT, Cooper GM, Doering JH, Dubourg C, Everman DB, Hildebrand MS, Santos FJR, Kellam B, Keller-Ramey J, Lemke JR, Liu S, Niyazov D, Payne K, Person R, Quélin C, Schnur RE, Smith BT, Strober J, Walker S, Wallis M, Walsh L, Yang S, Yuen RKC, Ziegler A, Sticht H, Pride MC, Orosco L, Martínez-Cerdeño V, Silverman JL, Crawley JN, Scherer SW, Zarbalis KS, Jamra R. PMID: 31327001; PMCID: PMC6736092.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    13. Ileal interposition surgery targets the hepatic TGF-β pathway, influencing gluconeogenesis and mitochondrial bioenergetics in the UCD-T2DM rat model of diabetes. FASEB J. 2019 10; 33(10):11270-11283. Hung C, Napoli E, Ross-Inta C, Graham J, Flores-Torres AL, Stanhope KL, Froment P, Havel PJ, Giulivi C. PMID: 31307210; PMCID: PMC6766639.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    14. Eye Opener in Stroke. Stroke. 2019 08; 50(8):2197-2206. Nguyen H, Lee JY, Sanberg PR, Napoli E, Borlongan CV. PMID: 31242827; PMCID: PMC6650274.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    15. Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults. Front Psychiatry. 2019; 10:207. Dhir S, Tarasenko M, Napoli E, Giulivi C. PMID: 31019473; PMCID: PMC6459027.
      View in: PubMed   Mentions: 64  
    16. Inhibition of JNK signaling in the Asian malaria vector Anopheles stephensi extends mosquito longevity and improves resistance to Plasmodium falciparum infection. PLoS Pathog. 2018 11; 14(11):e1007418. Souvannaseng L, Hun LV, Baker H, Klyver JM, Wang B, Pakpour N, Bridgewater JM, Napoli E, Giulivi C, Riehle MA, Luckhart S. PMID: 30496310; PMCID: PMC6264519.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCellsPHPublic Health
    17. May the force be with you: Transfer of healthy mitochondria from stem cells to stroke cells. J Cereb Blood Flow Metab. 2019 02; 39(2):367-370. Borlongan CV, Nguyen H, Lippert T, Russo E, Tuazon J, Xu K, Lee JY, Sanberg PR, Kaneko Y, Napoli E. PMID: 30375940; PMCID: PMC6365599.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    18. Mitochondrial targeting as a novel therapy for stroke. Brain Circ. 2018 Jul-Sep; 4(3):84-94. Russo E, Nguyen H, Lippert T, Tuazon J, Borlongan CV, Napoli E. PMID: 30450413; PMCID: PMC6187947.
      View in: PubMed   Mentions: 32  
    19. Healthy mitochondria for stroke cells. Brain Circ. 2018 Jul-Sep; 4(3):95-98. Russo E, Napoli E, Borlongan CV. PMID: 30450414; PMCID: PMC6187944.
      View in: PubMed   Mentions: 17  
    20. Allopregnanolone Treatment Improves Plasma Metabolomic Profile Associated with GABA Metabolism in Fragile X-Associated Tremor/Ataxia Syndrome: a Pilot Study. Mol Neurobiol. 2019 May; 56(5):3702-3713. Napoli E, Schneider A, Wang JY, Trivedi A, Carrillo NR, Tassone F, Rogawski M, Hagerman RJ, Giulivi C. PMID: 30187385; PMCID: PMC6401336.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCellsCTClinical Trials
    21. Impact of FMR1 Premutation on Neurobehavior and Bioenergetics in Young Monozygotic Twins. Front Genet. 2018; 9:338. Napoli E, Schneider A, Hagerman R, Song G, Wong S, Tassone F, Giulivi C. PMID: 30210529; PMCID: PMC6119880.
      View in: PubMed   Mentions: 11  
    22. Beyond autophagy: a novel role for autism-linked Wdfy3 in brain mitophagy. Sci Rep. 2018 07 27; 8(1):11348. Napoli E, Song G, Panoutsopoulos A, Riyadh MA, Kaushik G, Halmai J, Levenson R, Zarbalis KS, Giulivi C. PMID: 30054502; PMCID: PMC6063930.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    23. Understanding the Role of Dysfunctional and Healthy Mitochondria in Stroke Pathology and Its Treatment. Int J Mol Sci. 2018 Jul 21; 19(7). Nguyen H, Zarriello S, Rajani M, Tuazon J, Napoli E, Borlongan CV. PMID: 30037107; PMCID: PMC6073421.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    24. Adipose depot-specific effects of ileal interposition surgery in UCD-T2D rats: unexpected implications for obesity and diabetes. Biochem J. 2018 02 14; 475(3):649-662. Hung C, Bronec C, Napoli E, Graham J, Stanhope KL, Marsilio I, Giron MC, Havel PJ, Giulivi C. PMID: 29321243; PMCID: PMC7061453.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    25. Stem Cell Therapy: Repurposing Cell-Based Regenerative Medicine Beyond Cell Replacement. Adv Exp Med Biol. 2018; 1079:87-91. Napoli E, Lippert T, Borlongan CV. PMID: 29480446.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    26. Lipid-based DNA/siRNA transfection agents disrupt neuronal bioenergetics and mitophagy. Biochem J. 2017 11 10; 474(23):3887-3902. Napoli E, Liu S, Marsilio I, Zarbalis K, Giulivi C. PMID: 29025974.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    27. Zdhhc13-dependent Drp1 S-palmitoylation impacts brain bioenergetics, anxiety, coordination and motor skills. Sci Rep. 2017 10 16; 7(1):12796. Napoli E, Song G, Liu S, Espejo A, Perez CJ, Benavides F, Giulivi C. PMID: 29038583; PMCID: PMC5643561.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    28. Endogenous repair mechanisms enhanced in Parkinson's disease following stem cell therapy. Brain Circ. 2017 Jul-Sep; 3(3):163-166. Napoli E. PMID: 30276319; PMCID: PMC6057692.
      View in: PubMed   Mentions:
    29. Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion. Science. 2017 08 11; 357(6351):570-575. Byndloss MX, Olsan EE, Rivera-Chávez F, Tiffany CR, Cevallos SA, Lokken KL, Torres TP, Byndloss AJ, Faber F, Gao Y, Litvak Y, Lopez CA, Xu G, Napoli E, Giulivi C, Tsolis RM, Revzin A, Lebrilla CB, Bäumler AJ. PMID: 28798125; PMCID: PMC5642957.
      View in: PubMed   Mentions: 406     Fields:    Translation:HumansAnimalsCells
    30. Toll-Like Receptor 4 Modulates Small Intestine Neuromuscular Function through Nitrergic and Purinergic Pathways. Front Pharmacol. 2017; 8:350. Caputi V, Marsilio I, Cerantola S, Roozfarakh M, Lante I, Galuppini F, Rugge M, Napoli E, Giulivi C, Orso G, Giron MC. PMID: 28642706; PMCID: PMC5463746.
      View in: PubMed   Mentions: 27  
    31. Cell Therapy in Parkinson's Disease: Host Brain Repair Machinery Gets a Boost From Stem Cell Grafts. Stem Cells. 2017 06; 35(6):1443-1445. Napoli E, Borlongan CV. PMID: 28480563.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    32. Stem Cell Recipes of Bone Marrow and Fish: Just What the Stroke Doctors Ordered. Stem Cell Rev Rep. 2017 Apr; 13(2):192-197. Napoli E, Borlongan CV. PMID: 28064388.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    33. Harnessing neural stem cells for treating psychiatric symptoms associated with fetal alcohol spectrum disorder and epilepsy. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jan 03; 80(Pt A):10-22. Lippert T, Gelineau L, Napoli E, Borlongan CV. PMID: 28365374.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    34. Altered Bioenergetics in Primary Dermal Fibroblasts from Adult Carriers of the FMR1 Premutation Before the Onset of the Neurodegenerative Disease Fragile X-Associated Tremor/Ataxia Syndrome. Cerebellum. 2016 10; 15(5):552-64. Napoli E, Song G, Wong S, Hagerman R, Giulivi C. PMID: 27089882; PMCID: PMC5014718.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    35. Plasma metabolic profile delineates roles for neurodegeneration, pro-inflammatory damage and mitochondrial dysfunction in the FMR1 premutation. Biochem J. 2016 11 01; 473(21):3871-3888. Giulivi C, Napoli E, Tassone F, Halmai J, Hagerman R. PMID: 27555610; PMCID: PMC7014977.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    36. Plasma Biomarkers for Monitoring Brain Pathophysiology in FMR1 Premutation Carriers. Front Mol Neurosci. 2016; 9:71. Giulivi C, Napoli E, Tassone F, Halmai J, Hagerman R. PMID: 27570505; PMCID: PMC4981605.
      View in: PubMed   Mentions: 17  
    37. Recent Advances in Stem Cell-Based Therapeutics for Stroke. Transl Stroke Res. 2016 12; 7(6):452-457. Napoli E, Borlongan CV. PMID: 27515852; PMCID: PMC5065756.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    38. Two insulin-like peptides differentially regulate malaria parasite infection in the mosquito through effects on intermediary metabolism. Biochem J. 2016 Oct 15; 473(20):3487-3503. Pietri JE, Pakpour N, Napoli E, Song G, Pietri E, Potts R, Cheung KW, Walker G, Riehle MA, Starcevich H, Giulivi C, Lewis EE, Luckhart S. PMID: 27496548; PMCID: PMC5508860.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    39. Altered redox mitochondrial biology in the neurodegenerative disorder fragile X-tremor/ataxia syndrome: use of antioxidants in precision medicine. Mol Med. 2016 Oct; 22:548-559. Song G, Napoli E, Wong S, Hagerman R, Liu S, Tassone F, Giulivi C. PMID: 27385396; PMCID: PMC5082295.
      View in: PubMed   Mentions: 37     Fields:    
    40. Warburg effect linked to cognitive-executive deficits in FMR1 premutation. FASEB J. 2016 10; 30(10):3334-3351. Napoli E, Song G, Schneider A, Hagerman R, Eldeeb MA, Azarang A, Tassone F, Giulivi C. PMID: 27335370; PMCID: PMC5024697.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    41. Premutation in the Fragile X Mental Retardation 1 (FMR1) Gene Affects Maternal Zn-milk and Perinatal Brain Bioenergetics and Scaffolding. Front Neurosci. 2016; 10:159. Napoli E, Ross-Inta C, Song G, Wong S, Hagerman R, Gane LW, Smilowitz JT, Tassone F, Giulivi C. PMID: 27147951; PMCID: PMC4835505.
      View in: PubMed   Mentions: 22  
    42. Role of p53, Mitochondrial DNA Deletions, and Paternal Age in Autism: A Case-Control Study. Pediatrics. 2016 04; 137(4). Wong S, Napoli E, Krakowiak P, Tassone F, Hertz-Picciotto I, Giulivi C. PMID: 27033107; PMCID: PMC4811307.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    43. Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene. J Invest Dermatol. 2015 Dec; 135(12):3133-3143. Perez CJ, Mecklenburg L, Jaubert J, Martinez-Santamaria L, Iritani BM, Espejo A, Napoli E, Song G, Del Río M, DiGiovanni J, Giulivi C, Bedford MT, Dent SYR, Wood RD, Kusewitt DF, Guénet JL, Conti CJ, Benavides F. PMID: 26288350; PMCID: PMC4898190.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    44. Anopheles stephensi p38 MAPK signaling regulates innate immunity and bioenergetics during Plasmodium falciparum infection. Parasit Vectors. 2015 Aug 19; 8:424. Wang B, Pakpour N, Napoli E, Drexler A, Glennon EK, Surachetpong W, Cheung K, Aguirre A, Klyver JM, Lewis EE, Eigenheer R, Phinney BS, Giulivi C, Luckhart S. PMID: 26283222; PMCID: PMC4539710.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    45. Mitochondrial Citrate Transporter-dependent Metabolic Signature in the 22q11.2 Deletion Syndrome. J Biol Chem. 2015 Sep 18; 290(38):23240-53. Napoli E, Tassone F, Wong S, Angkustsiri K, Simon TJ, Song G, Giulivi C. PMID: 26221035; PMCID: PMC4645608.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    46. Impact of a novel homozygous mutation in nicotinamide nucleotide transhydrogenase on mitochondrial DNA integrity in a case of familial glucocorticoid deficiency. BBA Clin. 2015 Jun 01; 3:70-78. Fujisawa Y, Napoli E, Wong S, Song G, Yamaguchi R, Matsui T, Nagasaki K, Ogata T, Giulivi C. PMID: 26309815; PMCID: PMC4545511.
      View in: PubMed   Mentions: 11  
    47. Thiamine Deficiency-Mediated Brain Mitochondrial Pathology in Alaskan Huskies with Mutation in SLC19A3.1. Brain Pathol. 2015 Jul; 25(4):441-53. Vernau K, Napoli E, Wong S, Ross-Inta C, Cameron J, Bannasch D, Bollen A, Dickinson P, Giulivi C. PMID: 25117056; PMCID: PMC4326624.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    48. Potential therapeutic use of the ketogenic diet in autism spectrum disorders. Front Pediatr. 2014; 2:69. Napoli E, Dueñas N, Giulivi C. PMID: 25072037; PMCID: PMC4074854.
      View in: PubMed   Mentions: 24  
    49. Deficits in bioenergetics and impaired immune response in granulocytes from children with autism. Pediatrics. 2014 May; 133(5):e1405-10. Napoli E, Wong S, Hertz-Picciotto I, Giulivi C. PMID: 24753527; PMCID: PMC4006429.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    50. Clinical evaluation and biochemical analyses of thiamine deficiency in Pacific harbor seals (Phoca vitulina) maintained at a zoological facility. J Am Vet Med Assoc. 2013 Oct 15; 243(8):1179-89. Croft L, Napoli E, Hung CK, St Leger J, Gearhart S, Heym K, Wong S, Sakaguchi D, Lin A, Puschner B, Giulivi C. PMID: 24094267.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    51. Gestational exposure to a viral mimetic poly(i:C) results in long-lasting changes in mitochondrial function by leucocytes in the adult offspring. Mediators Inflamm. 2013; 2013:609602. Giulivi C, Napoli E, Schwartzer J, Careaga M, Ashwood P. PMID: 24174710; PMCID: PMC3793312.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCellsPHPublic Health
    52. Frataxin deficiency leads to defects in expression of antioxidants and Nrf2 expression in dorsal root ganglia of the Friedreich's ataxia YG8R mouse model. Antioxid Redox Signal. 2013 Nov 01; 19(13):1481-93. Shan Y, Schoenfeld RA, Hayashi G, Napoli E, Akiyama T, Iodi Carstens M, Carstens EE, Pook MA, Cortopassi GA. PMID: 23350650; PMCID: PMC3797453.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    53. Sustained activation of Akt elicits mitochondrial dysfunction to block Plasmodium falciparum infection in the mosquito host. PLoS Pathog. 2013 Feb; 9(2):e1003180. Luckhart S, Giulivi C, Drexler AL, Antonova-Koch Y, Sakaguchi D, Napoli E, Wong S, Price MS, Eigenheer R, Phinney BS, Pakpour N, Pietri JE, Cheung K, Georgis M, Riehle M. PMID: 23468624; PMCID: PMC3585164.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    54. Evidence of reactive oxygen species-mediated damage to mitochondrial DNA in children with typical autism. Mol Autism. 2013 Jan 25; 4(1):2. Napoli E, Wong S, Giulivi C. PMID: 23347615; PMCID: PMC3570390.
      View in: PubMed   Mentions: 47     Fields:    
    55. Toxicity of the flame-retardant BDE-49 on brain mitochondria and neuronal progenitor striatal cells enhanced by a PTEN-deficient background. Toxicol Sci. 2013 Mar; 132(1):196-210. Napoli E, Hung C, Wong S, Giulivi C. PMID: 23288049; PMCID: PMC3693513.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    56. Defective mitochondrial disulfide relay system, altered mitochondrial morphology and function in Huntington's disease. Hum Mol Genet. 2013 Mar 01; 22(5):989-1004. Napoli E, Wong S, Hung C, Ross-Inta C, Bomdica P, Giulivi C. PMID: 23197653; PMCID: PMC8482967.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    57. Mitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53. PLoS One. 2012; 7(8):e42504. Napoli E, Ross-Inta C, Wong S, Hung C, Fujisawa Y, Sakaguchi D, Angelastro J, Omanska-Klusek A, Schoenfeld R, Giulivi C. PMID: 22900024; PMCID: PMC3416855.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    58. Mitochondrial NAD+-dependent malic enzyme from Anopheles stephensi: a possible novel target for malaria mosquito control. Malar J. 2011 Oct 26; 10:318. Pon J, Napoli E, Luckhart S, Giulivi C. PMID: 22029897; PMCID: PMC3228860.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    59. Altered zinc transport disrupts mitochondrial protein processing/import in fragile X-associated tremor/ataxia syndrome. Hum Mol Genet. 2011 Aug 01; 20(15):3079-92. Napoli E, Ross-Inta C, Wong S, Omanska-Klusek A, Barrow C, Iwahashi C, Garcia-Arocena D, Sakaguchi D, Berry-Kravis E, Hagerman R, Hagerman PJ, Giulivi C. PMID: 21558427; PMCID: PMC3131047.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    60. Evaluation of senescence in mesenchymal stem cells isolated from equine bone marrow, adipose tissue, and umbilical cord tissue. Stem Cells Dev. 2012 Jan 20; 21(2):273-83. Vidal MA, Walker NJ, Napoli E, Borjesson DL. PMID: 21410356.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    61. Basal bioenergetic abnormalities in skeletal muscle from ryanodine receptor malignant hyperthermia-susceptible R163C knock-in mice. J Biol Chem. 2011 Jan 07; 286(1):99-113. Giulivi C, Ross-Inta C, Omanska-Klusek A, Napoli E, Sakaguchi D, Barrientos G, Allen PD, Pessah IN. PMID: 20978128; PMCID: PMC3013050.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    62. Activation of meiosis-specific genes is associated with depolyploidization of human tumor cells following radiation-induced mitotic catastrophe. Cancer Res. 2009 Mar 15; 69(6):2296-304. Ianzini F, Kosmacek EA, Nelson ES, Napoli E, Erenpreisa J, Kalejs M, Mackey MA. PMID: 19258501; PMCID: PMC2657811.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    63. Hemin rescues adrenodoxin, heme a and cytochrome oxidase activity in frataxin-deficient oligodendroglioma cells. Biochim Biophys Acta. 2007 Jul; 1772(7):773-80. Napoli E, Morin D, Bernhardt R, Buckpitt A, Cortopassi G. PMID: 17499976.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    64. Mitochondrial frataxin interacts with ISD11 of the NFS1/ISCU complex and multiple mitochondrial chaperones. Hum Mol Genet. 2007 Apr 15; 16(8):929-41. Shan Y, Napoli E, Cortopassi G. PMID: 17331979.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    65. Frataxin, iron-sulfur clusters, heme, ROS, and aging. Antioxid Redox Signal. 2006 Mar-Apr; 8(3-4):506-16. Napoli E, Taroni F, Cortopassi GA. PMID: 16677095; PMCID: PMC1805116.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    66. Frataxin deficiency alters heme pathway transcripts and decreases mitochondrial heme metabolites in mammalian cells. Hum Mol Genet. 2005 Dec 15; 14(24):3787-99. Schoenfeld RA, Napoli E, Wong A, Zhan S, Reutenauer L, Morin D, Buckpitt AR, Taroni F, Lonnerdal B, Ristow M, Puccio H, Cortopassi GA. PMID: 16239244.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    67. Antioxidant defences in cybrids harboring mtDNA mutations associated with Leber's hereditary optic neuropathy. FEBS J. 2005 Mar; 272(5):1124-35. Floreani M, Napoli E, Martinuzzi A, Pantano G, De Riva V, Trevisan R, Bisetto E, Valente L, Carelli V, Dabbeni-Sala F. PMID: 15720387.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    68. Antioxidant defences and homeostasis of reactive oxygen species in different human mitochondrial DNA-depleted cell lines. Eur J Biochem. 2004 Sep; 271(18):3646-56. Vergani L, Floreani M, Russell A, Ceccon M, Napoli E, Cabrelle A, Valente L, Bragantini F, Leger B, Dabbeni-Sala F. PMID: 15355341.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    69. Bioenergetics shapes cellular death pathways in Leber's hereditary optic neuropathy: a model of mitochondrial neurodegeneration. Biochim Biophys Acta. 2004 Jul 23; 1658(1-2):172-9. Carelli V, Rugolo M, Sgarbi G, Ghelli A, Zanna C, Baracca A, Lenaz G, Napoli E, Martinuzzi A, Solaini G. PMID: 15282189.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    70. Decreased expression of genes involved in sulfur amino acid metabolism in frataxin-deficient cells. Hum Mol Genet. 2003 Jul 15; 12(14):1699-711. Tan G, Napoli E, Taroni F, Cortopassi G. PMID: 12837693.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    71. Oral administration of trans-resveratrol to guinea pigs increases cardiac DT-diaphorase and catalase activities, and protects isolated atria from menadione toxicity. Life Sci. 2003 May 02; 72(24):2741-50. Floreani M, Napoli E, Quintieri L, Palatini P. PMID: 12679191.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    72. Role of antioxidant defences in the species-specific response of isolated atria to menadione. Comp Biochem Physiol C Toxicol Pharmacol. 2002 Jun; 132(2):143-51. Floreani M, Napoli E, Palatini P. PMID: 12106891.
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    73. Protective action of cardiac DT-diaphorase against menadione toxicity in guinea pig isolated atria. Biochem Pharmacol. 2000 Aug 15; 60(4):601-5. Floreani M, Napoli E, Palatini P. PMID: 10874136.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    74. In vivo antitumor activity and host toxicity of methoxymorpholinyl doxorubicin: role of cytochrome P450 3A. Cancer Res. 2000 Jun 15; 60(12):3232-8. Quintieri L, Rosato A, Napoli E, Sola F, Geroni C, Floreani M, Zanovello P. PMID: 10866316.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    75. Renal clearance of N(1)-methylnicotinamide: a sensitive marker of the severity of liver dysfunction in cirrhosis. Nephron. 2000 Jan; 84(1):32-9. Orlando R, Floreani M, Napoli E, Padrini R, Palatini P. PMID: 10644906.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
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