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Eleonora Napoli

Title(s)Associate Scientist, School of Veterinary Medicine
SchoolUniversity of California, Davis
Phone530-752-1038
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    My research focuses on the role of mitochondrial deficits in neurodegenerative disorders like Fragile X-Tremor/Ataxia Syndrome (FXTAS) and Huntington's disease (HD), but also on the involvement of bioenergetics and metabolic deficits in neurodevelopment disorders like ASD.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Crakes KR, Santos Rocha C, Grishina I, Hirao LA, Napoli E, Gaulke CA, Fenton A, Datta S, Arredondo J, Marco ML, Sankaran-Walters S, Cortopassi G, Giulivi C, Dandekar S. PPARa-targeted mitochondrial bioenergetics mediate repair of intestinal barriers at the host-microbe intersection during SIV infection. Proc Natl Acad Sci U S A. 2019 Dec 03; 116(49):24819-24829. PMID: 31740620.
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    2. McMackin MZ, Durbin-Johnson B, Napierala M, Napierala JS, Ruiz L, Napoli E, Perlman S, Giulivi C, Cortopassi GA. Potential biomarker identification for Friedreich's ataxia using overlapping gene expression patterns in patient cells and mouse dorsal root ganglion. PLoS One. 2019; 14(10):e0223209. PMID: 31665133.
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    3. Le Duc D, Giulivi C, Hiatt SM, Napoli E, Panoutsopoulos A, Harlan De Crescenzo A, Kotzaeridou U, Syrbe S, Anagnostou E, Azage M, Bend R, Begtrup A, Brown NJ, Büttner B, Cho MT, Cooper GM, Doering JH, Dubourg C, Everman DB, Hildebrand MS, Santos FJR, Kellam B, Keller-Ramey J, Lemke JR, Liu S, Niyazov D, Payne K, Person R, Quélin C, Schnur RE, Smith BT, Strober J, Walker S, Wallis M, Walsh L, Yang S, Yuen RKC, Ziegler A, Sticht H, Pride MC, Orosco L, Martínez-Cerdeño V, Silverman JL, Crawley JN, Scherer SW, Zarbalis KS, Jamra R. Pathogenic WDFY3 variants cause neurodevelopmental disorders and opposing effects on brain size. Brain. 2019 Sep 01; 142(9):2617-2630. PMID: 31327001.
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    4. Hung C, Napoli E, Ross-Inta C, Graham J, Flores-Torres AL, Stanhope KL, Froment P, Havel PJ, Giulivi C. Ileal interposition surgery targets the hepatic TGF-ß pathway, influencing gluconeogenesis and mitochondrial bioenergetics in the UCD-T2DM rat model of diabetes. FASEB J. 2019 Oct; 33(10):11270-11283. PMID: 31307210.
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    5. Dhir S, Tarasenko M, Napoli E, Giulivi C. Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults. Front Psychiatry. 2019; 10:207. PMID: 31019473.
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    6. Souvannaseng L, Hun LV, Baker H, Klyver JM, Wang B, Pakpour N, Bridgewater JM, Napoli E, Giulivi C, Riehle MA, Luckhart S. Inhibition of JNK signaling in the Asian malaria vector Anopheles stephensi extends mosquito longevity and improves resistance to Plasmodium falciparum infection. PLoS Pathog. 2018 11; 14(11):e1007418. PMID: 30496310.
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    7. Napoli E, Schneider A, Wang JY, Trivedi A, Carrillo NR, Tassone F, Rogawski M, Hagerman RJ, Giulivi C. Allopregnanolone Treatment Improves Plasma Metabolomic Profile Associated with GABA Metabolism in Fragile X-Associated Tremor/Ataxia Syndrome: a Pilot Study. Mol Neurobiol. 2019 May; 56(5):3702-3713. PMID: 30187385.
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    8. Napoli E, Schneider A, Hagerman R, Song G, Wong S, Tassone F, Giulivi C. Impact of FMR1 Premutation on Neurobehavior and Bioenergetics in Young Monozygotic Twins. Front Genet. 2018; 9:338. PMID: 30210529.
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    9. Napoli E, Song G, Panoutsopoulos A, Riyadh MA, Kaushik G, Halmai J, Levenson R, Zarbalis KS, Giulivi C. Beyond autophagy: a novel role for autism-linked Wdfy3 in brain mitophagy. Sci Rep. 2018 07 27; 8(1):11348. PMID: 30054502.
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    10. Hung C, Bronec C, Napoli E, Graham J, Stanhope KL, Marsilio I, Giron MC, Havel PJ, Giulivi C. Adipose depot-specific effects of ileal interposition surgery in UCD-T2D rats: unexpected implications for obesity and diabetes. Biochem J. 2018 02 14; 475(3):649-662. PMID: 29321243.
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    11. Napoli E, Liu S, Marsilio I, Zarbalis K, Giulivi C. Lipid-based DNA/siRNA transfection agents disrupt neuronal bioenergetics and mitophagy. Biochem J. 2017 11 10; 474(23):3887-3902. PMID: 29025974.
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    12. Napoli E, Song G, Liu S, Espejo A, Perez CJ, Benavides F, Giulivi C. Zdhhc13-dependent Drp1 S-palmitoylation impacts brain bioenergetics, anxiety, coordination and motor skills. Sci Rep. 2017 10 16; 7(1):12796. PMID: 29038583.
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    13. Byndloss MX, Olsan EE, Rivera-Chávez F, Tiffany CR, Cevallos SA, Lokken KL, Torres TP, Byndloss AJ, Faber F, Gao Y, Litvak Y, Lopez CA, Xu G, Napoli E, Giulivi C, Tsolis RM, Revzin A, Lebrilla CB, Bäumler AJ. Microbiota-activated PPAR-? signaling inhibits dysbiotic Enterobacteriaceae expansion. Science. 2017 08 11; 357(6351):570-575. PMID: 28798125.
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    14. Caputi V, Marsilio I, Cerantola S, Roozfarakh M, Lante I, Galuppini F, Rugge M, Napoli E, Giulivi C, Orso G, Giron MC. Toll-Like Receptor 4 Modulates Small Intestine Neuromuscular Function through Nitrergic and Purinergic Pathways. Front Pharmacol. 2017; 8:350. PMID: 28642706.
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    15. Napoli E, Song G, Wong S, Hagerman R, Giulivi C. Altered Bioenergetics in Primary Dermal Fibroblasts from Adult Carriers of the FMR1 Premutation Before the Onset of the Neurodegenerative Disease Fragile X-Associated Tremor/Ataxia Syndrome. Cerebellum. 2016 10; 15(5):552-64. PMID: 27089882.
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    16. Giulivi C, Napoli E, Tassone F, Halmai J, Hagerman R. Plasma metabolic profile delineates roles for neurodegeneration, pro-inflammatory damage and mitochondrial dysfunction in the FMR1 premutation. Biochem J. 2016 11 01; 473(21):3871-3888. PMID: 27555610.
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    17. Giulivi C, Napoli E, Tassone F, Halmai J, Hagerman R. Plasma Biomarkers for Monitoring Brain Pathophysiology in FMR1 Premutation Carriers. Front Mol Neurosci. 2016; 9:71. PMID: 27570505.
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    18. Pietri JE, Pakpour N, Napoli E, Song G, Pietri E, Potts R, Cheung KW, Walker G, Riehle MA, Starcevich H, Giulivi C, Lewis EE, Luckhart S. Two insulin-like peptides differentially regulate malaria parasite infection in the mosquito through effects on intermediary metabolism. Biochem J. 2016 Oct 15; 473(20):3487-3503. PMID: 27496548.
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    19. Song G, Napoli E, Wong S, Hagerman R, Liu S, Tassone F, Giulivi C. Altered redox mitochondrial biology in the neurodegenerative disorder fragile X-tremor/ataxia syndrome: use of antioxidants in precision medicine. Mol Med. 2016 Oct; 22:548-559. PMID: 27385396.
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    20. Napoli E, Song G, Schneider A, Hagerman R, Eldeeb MA, Azarang A, Tassone F, Giulivi C. Warburg effect linked to cognitive-executive deficits in FMR1 premutation. FASEB J. 2016 10; 30(10):3334-3351. PMID: 27335370.
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    21. Napoli E, Ross-Inta C, Song G, Wong S, Hagerman R, Gane LW, Smilowitz JT, Tassone F, Giulivi C. Premutation in the Fragile X Mental Retardation 1 (FMR1) Gene Affects Maternal Zn-milk and Perinatal Brain Bioenergetics and Scaffolding. Front Neurosci. 2016; 10:159. PMID: 27147951.
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    22. Wong S, Napoli E, Krakowiak P, Tassone F, Hertz-Picciotto I, Giulivi C. Role of p53, Mitochondrial DNA Deletions, and Paternal Age in Autism: A Case-Control Study. Pediatrics. 2016 04; 137(4). PMID: 27033107.
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    23. Wang B, Pakpour N, Napoli E, Drexler A, Glennon EK, Surachetpong W, Cheung K, Aguirre A, Klyver JM, Lewis EE, Eigenheer R, Phinney BS, Giulivi C, Luckhart S. Anopheles stephensi p38 MAPK signaling regulates innate immunity and bioenergetics during Plasmodium falciparum infection. Parasit Vectors. 2015 Aug 19; 8:424. PMID: 26283222.
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    24. Perez CJ, Mecklenburg L, Jaubert J, Martinez-Santamaria L, Iritani BM, Espejo A, Napoli E, Song G, Del Río M, DiGiovanni J, Giulivi C, Bedford MT, Dent SYR, Wood RD, Kusewitt DF, Guénet JL, Conti CJ, Benavides F. Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene. J Invest Dermatol. 2015 Dec; 135(12):3133-3143. PMID: 26288350.
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    25. Napoli E, Tassone F, Wong S, Angkustsiri K, Simon TJ, Song G, Giulivi C. Mitochondrial Citrate Transporter-dependent Metabolic Signature in the 22q11.2 Deletion Syndrome. J Biol Chem. 2015 Sep 18; 290(38):23240-53. PMID: 26221035.
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    26. Fujisawa Y, Napoli E, Wong S, Song G, Yamaguchi R, Matsui T, Nagasaki K, Ogata T, Giulivi C. Impact of a novel homozygous mutation in nicotinamide nucleotide transhydrogenase on mitochondrial DNA integrity in a case of familial glucocorticoid deficiency. BBA Clin. 2015 Jun 01; 3:70-78. PMID: 26309815.
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    27. Vernau K, Napoli E, Wong S, Ross-Inta C, Cameron J, Bannasch D, Bollen A, Dickinson P, Giulivi C. Thiamine Deficiency-Mediated Brain Mitochondrial Pathology in Alaskan Huskies with Mutation in SLC19A3.1. Brain Pathol. 2015 Jul; 25(4):441-53. PMID: 25117056.
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    28. Napoli E, Dueñas N, Giulivi C. Potential therapeutic use of the ketogenic diet in autism spectrum disorders. Front Pediatr. 2014; 2:69. PMID: 25072037.
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    29. Napoli E, Wong S, Hertz-Picciotto I, Giulivi C. Deficits in bioenergetics and impaired immune response in granulocytes from children with autism. Pediatrics. 2014 May; 133(5):e1405-10. PMID: 24753527.
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    30. Croft L, Napoli E, Hung CK, St Leger J, Gearhart S, Heym K, Wong S, Sakaguchi D, Lin A, Puschner B, Giulivi C. Clinical evaluation and biochemical analyses of thiamine deficiency in Pacific harbor seals (Phoca vitulina) maintained at a zoological facility. J Am Vet Med Assoc. 2013 Oct 15; 243(8):1179-89. PMID: 24094267.
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    31. Giulivi C, Napoli E, Schwartzer J, Careaga M, Ashwood P. Gestational exposure to a viral mimetic poly(i:C) results in long-lasting changes in mitochondrial function by leucocytes in the adult offspring. Mediators Inflamm. 2013; 2013:609602. PMID: 24174710.
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    32. Shan Y, Schoenfeld RA, Hayashi G, Napoli E, Akiyama T, Iodi Carstens M, Carstens EE, Pook MA, Cortopassi GA. Frataxin deficiency leads to defects in expression of antioxidants and Nrf2 expression in dorsal root ganglia of the Friedreich's ataxia YG8R mouse model. Antioxid Redox Signal. 2013 Nov 01; 19(13):1481-93. PMID: 23350650.
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    33. Luckhart S, Giulivi C, Drexler AL, Antonova-Koch Y, Sakaguchi D, Napoli E, Wong S, Price MS, Eigenheer R, Phinney BS, Pakpour N, Pietri JE, Cheung K, Georgis M, Riehle M. Sustained activation of Akt elicits mitochondrial dysfunction to block Plasmodium falciparum infection in the mosquito host. PLoS Pathog. 2013 Feb; 9(2):e1003180. PMID: 23468624.
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    34. Napoli E, Wong S, Giulivi C. Evidence of reactive oxygen species-mediated damage to mitochondrial DNA in children with typical autism. Mol Autism. 2013 Jan 25; 4(1):2. PMID: 23347615.
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    35. Napoli E, Hung C, Wong S, Giulivi C. Toxicity of the flame-retardant BDE-49 on brain mitochondria and neuronal progenitor striatal cells enhanced by a PTEN-deficient background. Toxicol Sci. 2013 Mar; 132(1):196-210. PMID: 23288049.
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    36. Napoli E, Wong S, Hung C, Ross-Inta C, Bomdica P, Giulivi C. Defective mitochondrial disulfide relay system, altered mitochondrial morphology and function in Huntington's disease. Hum Mol Genet. 2013 Mar 01; 22(5):989-1004. PMID: 23197653.
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    37. Napoli E, Ross-Inta C, Wong S, Hung C, Fujisawa Y, Sakaguchi D, Angelastro J, Omanska-Klusek A, Schoenfeld R, Giulivi C. Mitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53. PLoS One. 2012; 7(8):e42504. PMID: 22900024.
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    38. Pon J, Napoli E, Luckhart S, Giulivi C. Mitochondrial NAD+-dependent malic enzyme from Anopheles stephensi: a possible novel target for malaria mosquito control. Malar J. 2011 Oct 26; 10:318. PMID: 22029897.
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    39. Napoli E, Ross-Inta C, Wong S, Omanska-Klusek A, Barrow C, Iwahashi C, Garcia-Arocena D, Sakaguchi D, Berry-Kravis E, Hagerman R, Hagerman PJ, Giulivi C. Altered zinc transport disrupts mitochondrial protein processing/import in fragile X-associated tremor/ataxia syndrome. Hum Mol Genet. 2011 Aug 01; 20(15):3079-92. PMID: 21558427.
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    40. Vidal MA, Walker NJ, Napoli E, Borjesson DL. Evaluation of senescence in mesenchymal stem cells isolated from equine bone marrow, adipose tissue, and umbilical cord tissue. Stem Cells Dev. 2012 Jan 20; 21(2):273-83. PMID: 21410356.
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    41. Giulivi C, Ross-Inta C, Omanska-Klusek A, Napoli E, Sakaguchi D, Barrientos G, Allen PD, Pessah IN. Basal bioenergetic abnormalities in skeletal muscle from ryanodine receptor malignant hyperthermia-susceptible R163C knock-in mice. J Biol Chem. 2011 Jan 07; 286(1):99-113. PMID: 20978128.
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    42. Ianzini F, Kosmacek EA, Nelson ES, Napoli E, Erenpreisa J, Kalejs M, Mackey MA. Activation of meiosis-specific genes is associated with depolyploidization of human tumor cells following radiation-induced mitotic catastrophe. Cancer Res. 2009 Mar 15; 69(6):2296-304. PMID: 19258501.
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    43. Napoli E, Morin D, Bernhardt R, Buckpitt A, Cortopassi G. Hemin rescues adrenodoxin, heme a and cytochrome oxidase activity in frataxin-deficient oligodendroglioma cells. Biochim Biophys Acta. 2007 Jul; 1772(7):773-80. PMID: 17499976.
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    44. Shan Y, Napoli E, Cortopassi G. Mitochondrial frataxin interacts with ISD11 of the NFS1/ISCU complex and multiple mitochondrial chaperones. Hum Mol Genet. 2007 Apr 15; 16(8):929-41. PMID: 17331979.
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    45. Napoli E, Taroni F, Cortopassi GA. Frataxin, iron-sulfur clusters, heme, ROS, and aging. Antioxid Redox Signal. 2006 Mar-Apr; 8(3-4):506-16. PMID: 16677095.
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    46. Schoenfeld RA, Napoli E, Wong A, Zhan S, Reutenauer L, Morin D, Buckpitt AR, Taroni F, Lonnerdal B, Ristow M, Puccio H, Cortopassi GA. Frataxin deficiency alters heme pathway transcripts and decreases mitochondrial heme metabolites in mammalian cells. Hum Mol Genet. 2005 Dec 15; 14(24):3787-99. PMID: 16239244.
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    47. Floreani M, Napoli E, Martinuzzi A, Pantano G, De Riva V, Trevisan R, Bisetto E, Valente L, Carelli V, Dabbeni-Sala F. Antioxidant defences in cybrids harboring mtDNA mutations associated with Leber's hereditary optic neuropathy. FEBS J. 2005 Mar; 272(5):1124-35. PMID: 15720387.
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    48. Vergani L, Floreani M, Russell A, Ceccon M, Napoli E, Cabrelle A, Valente L, Bragantini F, Leger B, Dabbeni-Sala F. Antioxidant defences and homeostasis of reactive oxygen species in different human mitochondrial DNA-depleted cell lines. Eur J Biochem. 2004 Sep; 271(18):3646-56. PMID: 15355341.
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    49. Carelli V, Rugolo M, Sgarbi G, Ghelli A, Zanna C, Baracca A, Lenaz G, Napoli E, Martinuzzi A, Solaini G. Bioenergetics shapes cellular death pathways in Leber's hereditary optic neuropathy: a model of mitochondrial neurodegeneration. Biochim Biophys Acta. 2004 Jul 23; 1658(1-2):172-9. PMID: 15282189.
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    50. Tan G, Napoli E, Taroni F, Cortopassi G. Decreased expression of genes involved in sulfur amino acid metabolism in frataxin-deficient cells. Hum Mol Genet. 2003 Jul 15; 12(14):1699-711. PMID: 12837693.
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    51. Floreani M, Napoli E, Quintieri L, Palatini P. Oral administration of trans-resveratrol to guinea pigs increases cardiac DT-diaphorase and catalase activities, and protects isolated atria from menadione toxicity. Life Sci. 2003 May 02; 72(24):2741-50. PMID: 12679191.
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    52. Floreani M, Napoli E, Palatini P. Role of antioxidant defences in the species-specific response of isolated atria to menadione. Comp Biochem Physiol C Toxicol Pharmacol. 2002 Jun; 132(2):143-51. PMID: 12106891.
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    53. Floreani M, Napoli E, Palatini P. Protective action of cardiac DT-diaphorase against menadione toxicity in guinea pig isolated atria. Biochem Pharmacol. 2000 Aug 15; 60(4):601-5. PMID: 10874136.
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    54. Quintieri L, Rosato A, Napoli E, Sola F, Geroni C, Floreani M, Zanovello P. In vivo antitumor activity and host toxicity of methoxymorpholinyl doxorubicin: role of cytochrome P450 3A. Cancer Res. 2000 Jun 15; 60(12):3232-8. PMID: 10866316.
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    55. Orlando R, Floreani M, Napoli E, Padrini R, Palatini P. Renal clearance of N(1)-methylnicotinamide: a sensitive marker of the severity of liver dysfunction in cirrhosis. Nephron. 2000 Jan; 84(1):32-9. PMID: 10644906.
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