David Randal Hessl

Title(s)Professor, Psychiatry and Behavioral Sciences
SchoolSchool of Medicine
AddressMIND Bldg/UCDMC
CA 95817
Phone916-703-0249
ORCID ORCID Icon0000-0002-3460-9805 Additional info
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    Collapse Biography 
    Collapse Education and Training
    UCLA, Los AngelesBA1989Psychology
    University of Washington, Seattle, WAPhD1997Clinical Psychology
    University of Washington, Seattle, WAMS1995Clinical Psychology
    Collapse Awards and Honors
    National Fragile X Foundation2023  - 2023Randi and Paul Hagerman Award
    John Merck Fund2012  - 2019John Merck Scholar in Developmental Disabilities
    National Fragile X Foundation2012  - 2012Jarrett Cole Award

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    A Cognitive Test Battery for Intellectual Disabilities
    NIH/NICHD R01HD076189Sep 22, 2014 - Jun 30, 2019
    Role: Principal Investigator
    Trajectories and Markers of Neurodegeneration in Fragile X Premutation Carriers
    NIH/NINDS R01NS110100Jun 1, 2007 - May 31, 2023
    Role: Co-Principal Investigator
    Trajectories and Markers of Neurodegeneration in Fragile X Premutation Carriers
    NIH/NIMH R01MH078041Jul 1, 2006 - Mar 31, 2018
    Role: Principal Investigator
    Genetics and Physiology of Social Anxiety in Fragile X
    NIH/NIMH K23MH077554Sep 30, 2005 - Jul 31, 2010
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Developmental Associations between Cognition and Adaptive Behavior in Intellectual and Developmental Disability. Res Sq. 2024 Jan 08. Dakopolos A, Condy E, Smith E, Harvey D, Kaat AJ, Coleman J, Riley K, Berry-Kravis E, Hessl D. PMID: 38260292; PMCID: PMC10802716.
      View in: PubMed   Mentions:
    2. FMR1 Carriers Report Executive Function Changes Prior to Fragile X-Associated Tremor/Ataxia Syndrome: A Longitudinal Study. Mov Disord. 2023 Dec 20. Hessl D, Mandujano Rojas K, Ferrer E, Espinal G, Famula J, Schneider A, Hagerman R, Tassone F, Rivera SM. PMID: 38124331.
      View in: PubMed   Mentions:    Fields:    
    3. iBehavior-a preliminary proof of concept study of a smartphone-based tool for the assessment of behavior change in neurodevelopmental disabilities. Front Psychol. 2023; 14:1217821. Dakopolos A, Glassman D, Scott H, Bass M, Hessl D. PMID: 37920743; PMCID: PMC10619652.
      View in: PubMed   Mentions:
    4. Insight and Recommendations for Fragile X-Premutation-Associated Conditions from the Fifth International Conference on FMR1 Premutation. Cells. 2023 09 21; 12(18). Tassone F, Protic D, Allen EG, Archibald AD, Baud A, Brown TW, Budimirovic DB, Cohen J, Dufour B, Eiges R, Elvassore N, Gabis LV, Grudzien SJ, Hall DA, Hessl D, Hogan A, Hunter JE, Jin P, Jiraanont P, Klusek J, Kooy RF, Kraan CM, Laterza C, Lee A, Lipworth K, Losh M, Loesch D, Lozano R, Mailick MR, Manolopoulos A, Martinez-Cerdeno V, McLennan Y, Miller RM, Montanaro FAM, Mosconi MW, Potter SN, Raspa M, Rivera SM, Shelly K, Todd PK, Tutak K, Wang JY, Wheeler A, Winarni TI, Zafarullah M, Hagerman RJ. PMID: 37759552; PMCID: PMC10529056.
      View in: PubMed   Mentions: 4     Fields:    
    5. Adaptive, behavioral, and cognitive outcomes in individuals with fragile X syndrome with varying autism severity. Int J Dev Neurosci. 2023 Dec; 83(8):715-727. Aishworiya R, Tak YE, Ponzini MD, Biag HMB, Salcedo-Arellano MJ, Kim K, Tassone F, Schneider A, Thurman AJ, Abbeduto L, Hessl D, Randol JL, Bolduc FV, Lippe S, Hagerman P, Hagerman R. PMID: 37724826; PMCID: PMC10868665.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. A Longitudinal Study of Executive Function in Daily Life in Male Fragile X Premutation Carriers and Association with FXTAS Conversion. medRxiv. 2023 Sep 02. Hessl D, Rojas KM, Ferrer E, Espinal G, Famula J, Schneider A, Elagerman R, Tassone F, Rivera SM. PMID: 37693384; PMCID: PMC10491369.
      View in: PubMed   Mentions:
    7. Effects of AFQ056 on language learning in fragile X syndrome. J Clin Invest. 2023 Aug 31; 134(5). Berry-Kravis E, Abbeduto L, Hagerman R, Coffey CS, Cudkowicz M, Erickson CA, McDuffie A, Hessl D, Ethridge L, Tassone F, Kaufmann WE, Friedmann K, Bullard L, Hoffmann A, Veenstra-VanderWeele J, Staley K, Klements D, Moshinsky M, Harkey B, Long J, Fedler J, Klingner E, Ecklund D, Costigan M, Huff T, Pearson B, NeuroNEXT FXLEARN Investigators. PMID: 37651202; PMCID: PMC10904045.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    8. Blood Proteome Profiling Reveals Biomarkers and Pathway Alterations in Fragile X PM at Risk for Developing FXTAS. Int J Mol Sci. 2023 Aug 30; 24(17). Zafarullah M, Li J, Salemi MR, Phinney BS, Durbin-Johnson BP, Hagerman R, Hessl D, Rivera SM, Tassone F. PMID: 37686279; PMCID: PMC10488017.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Deviation scores: An innovative approach to interpreting cognitive test results for individuals with intellectual disabilities. J Appl Res Intellect Disabil. 2023 Nov; 36(6):1218-1228. Talapatra D, Snider L, Coleman J, Thompson T, Reinhardt JS, Hessl D, Riley K. PMID: 37553958; PMCID: PMC10591767.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Intercorrelation of Molecular Biomarkers and Clinical Phenotype Measures in Fragile X Syndrome. Cells. 2023 07 24; 12(14). Aishworiya R, Chi MH, Zafarullah M, Mendoza G, Ponzini MD, Kim K, Biag HMB, Thurman AJ, Abbeduto L, Hessl D, Randol JL, Bolduc FV, Jacquemont S, Lippé S, Hagerman P, Hagerman R, Schneider A, Tassone F. PMID: 37508583; PMCID: PMC10377864.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. The comparison of expressed emotion of parents of individuals with fragile X syndrome to other intellectual disabilities. J Appl Res Intellect Disabil. 2023 Mar; 36(2):394-404. Coleman J, Thompson T, Riley K, Allen K, Michalak C, Shields R, Berry-Kravis E, Hessl D. PMID: 36647196; PMCID: PMC10381095.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    12. Sensitivity of the NIH Toolbox to Detect Cognitive Change in Individuals With Intellectual and Developmental Disability. Neurology. 2023 02 21; 100(8):e778-e789. Shields RH, Kaat A, Sansone SM, Michalak C, Coleman J, Thompson T, McKenzie FJ, Dakopolos A, Riley K, Berry-Kravis E, Widaman KF, Gershon RC, Hessl D. PMID: 36460468; PMCID: PMC9984222.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    13. Tophaceous gout of the nose in a male FMR1 premutation carrier. Clin Case Rep. 2022 Nov; 10(11):e6586. Tang SJ, Giri S, Pahlavan N, Han SH, Santos ER, Espinal G, Aishworiya R, Schneider A, Hessl D, Rivera SM, Hagerman RJ. PMID: 36447664; PMCID: PMC9701845.
      View in: PubMed   Mentions:
    14. Observable Symptoms of Anxiety in Individuals with Fragile X Syndrome: Parent and Caregiver Perspectives. Genes (Basel). 2022 09 16; 13(9). Lozano R, Thompson T, Dixon-Weber J, Erickson CA, Berry-Kravis E, Williams S, Smith E, Frazier JA, Rosselot H, Farmer C, Hessl D. PMID: 36140827; PMCID: PMC9498703.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    15. Fragile X-associated tremor ataxia syndrome rating scale: Revision and content validity using a mixed method approach. Front Neurol. 2022; 13:977380. Tosin MHS, Stebbins GT, Goetz CG, Hagerman RJ, Hessl D, Zolecki MA, Todd PK, Leehey MA, Hall DA. PMID: 36188408; PMCID: PMC9515309.
      View in: PubMed   Mentions:
    16. Working Memory Training in Youth With Autism, Fragile X, and Intellectual Disability: A Pilot Study. Am J Intellect Dev Disabil. 2022 09 01; 127(5):369-389. Calub CA, Benyakorn S, Sun S, Iosif AM, Boyle LH, Solomon M, Hessl D, Schweitzer JB. PMID: 36018768; PMCID: PMC9915337.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. The International Fragile X Premutation Registry: building a resource for research and clinical trial readiness. J Med Genet. 2022 12; 59(12):1165-1170. Hessl D, Rosselot H, Miller R, Espinal G, Famula J, Sherman SL, Todd PK, Cabal Herrera AM, Lipworth K, Cohen J, Hall DA, Leehey M, Grigsby J, Weber JD, Alusi S, Wheeler A, Raspa M, Hudson T, Sobrian SK. PMID: 35701103; PMCID: PMC9691813.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    18. Prosaccade and Antisaccade Behavior in Fragile X-Associated Tremor/Ataxia Syndrome Progression. Mov Disord Clin Pract. 2022 May; 9(4):473-478. McLennan YA, Mosconi MW, McKenzie FJ, Famula J, Krawchuk B, Kim K, Clark CJ, Hessl D, Rivera SM, Simon TJ, Tassone F, Hagerman RJ. PMID: 35586536; PMCID: PMC9092736.
      View in: PubMed   Mentions: 1  
    19. Neuropsychological changes in FMR1 premutation carriers and onset of fragile X-associated tremor/ataxia syndrome. J Neurodev Disord. 2022 03 23; 14(1):23. Famula J, Ferrer E, Hagerman RJ, Tassone F, Schneider A, Rivera SM, Hessl D. PMID: 35321639; PMCID: PMC8942145.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    20. Corrigendum: EEG Signal Complexity Is Reduced During Resting-State in Fragile X Syndrome. Front Psychiatry. 2022; 13:867000. Proteau-Lemieux M, Knoth IS, Agbogba K, Côté V, Barlahan Biag HM, Thurman AJ, Martin CO, Bélanger AM, Rosenfelt C, Tassone F, Abbeduto LJ, Jacquemont S, Hagerman R, Bolduc F, Hessl D, Schneider A, Lippé S. PMID: 35280176; PMCID: PMC8908967.
      View in: PubMed   Mentions: 1  
    21. Clinical and Molecular Correlates of Abnormal Changes in the Cerebellum and Globus Pallidus in Fragile X Premutation. Front Neurol. 2022; 13:797649. Wang JY, Grigsby J, Placido D, Wei H, Tassone F, Kim K, Hessl D, Rivera SM, Hagerman RJ. PMID: 35211082; PMCID: PMC8863211.
      View in: PubMed   Mentions: 1  
    22. EEG Signal Complexity Is Reduced During Resting-State in Fragile X Syndrome. Front Psychiatry. 2021; 12:716707. Proteau-Lemieux M, Knoth IS, Agbogba K, Côté V, Barlahan Biag HM, Thurman AJ, Martin CO, Bélanger AM, Rosenfelt C, Tassone F, Abbeduto LJ, Jacquemont S, Hagerman R, Bolduc F, Hessl D, Schneider A, Lippé S. PMID: 34858220; PMCID: PMC8632368.
      View in: PubMed   Mentions: 4  
    23. Metabolomic Biomarkers Are Associated With Area of the Pons in Fragile X Premutation Carriers at Risk for Developing FXTAS. Front Psychiatry. 2021; 12:691717. Zafarullah M, Durbin-Johnson B, Fourie ES, Hessl DR, Rivera SM, Tassone F. PMID: 34483988; PMCID: PMC8415564.
      View in: PubMed   Mentions: 1  
    24. Assessing processing speed among individuals with intellectual and developmental disabilities: A match-to-sample paradigm. Child Neuropsychol. 2022 01; 28(1):1-13. Kaat AJ, McKenzie FJ, Shields RH, LaForte E, Coleman J, Michalak C, Hessl DR. PMID: 34126855; PMCID: PMC8648883.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    25. Emergence of Developmental Delay in Infants and Toddlers With an FMR1 Mutation. Pediatrics. 2021 05; 147(5). Wheeler AC, Gwaltney A, Raspa M, Okoniewski KC, Berry-Kravis E, Botteron KN, Budimirovic D, Hazlett HC, Hessl D, Losh M, Martin GE, Rivera SM, Roberts JE, Bailey DB. PMID: 33911031; PMCID: PMC8086007.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    26. Fear Potentiated Startle in Children With Autism Spectrum Disorder: Association With Anxiety Symptoms and Amygdala Volume. Autism Res. 2021 03; 14(3):450-463. Hessl D, Libero L, Schneider A, Kerns C, Winder-Patel B, Heath B, Lee J, Coleman C, Sharma N, Solomon M, Nordahl CW, Amaral DG. PMID: 33372389; PMCID: PMC8443003.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    27. Metabolic profiling reveals dysregulated lipid metabolism and potential biomarkers associated with the development and progression of Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS). FASEB J. 2020 12; 34(12):16676-16692. Zafarullah M, Palczewski G, Rivera SM, Hessl DR, Tassone F. PMID: 33131090; PMCID: PMC7756608.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    28. Soy-Based Infant Formula is Associated with an Increased Prevalence of Comorbidities in Fragile X Syndrome. Nutrients. 2020 Oct 14; 12(10). Westmark CJ, Kniss C, Sampene E, Wang A, Milunovich A, Elver K, Hessl D, Talboy A, Picker J, Haas-Givler B, Esler A, Gropman AL, Uy R, Erickson C, Velinov M, Tartaglia N, Berry-Kravis EM. PMID: 33066511; PMCID: PMC7602206.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    29. Using the NIH Toolbox to Assess Cognition in Adolescents and Young Adults with Autism Spectrum Disorders. Autism Res. 2021 03; 14(3):500-511. Solomon M, Gordon A, Iosif AM, Geddert R, Krug MK, Mundy P, Hessl D. PMID: 33006263; PMCID: PMC8106946.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    30. Cognitive Training Deep Dive: The Impact of Child, Training Behavior and Environmental Factors within a Controlled Trial of Cogmed for Fragile X Syndrome. Brain Sci. 2020 Sep 25; 10(10). Scott H, Harvey DJ, Li Y, McLennan YA, Johnston CK, Shickman R, Piven J, Schweitzer JB, Hessl D. PMID: 32992879; PMCID: PMC7601580.
      View in: PubMed   Mentions: 2  
    31. Women with Fragile X-associated Tremor/Ataxia Syndrome. Mov Disord Clin Pract. 2020 Nov; 7(8):910-919. Schneider A, Summers S, Tassone F, Seritan A, Hessl D, Hagerman P, Hagerman R. PMID: 33163562; PMCID: PMC7604678.
      View in: PubMed   Mentions: 10  
    32. Response to Placebo in Fragile X Syndrome Clinical Trials: An Initial Analysis. Brain Sci. 2020 Sep 11; 10(9). Luu S, Province H, Berry-Kravis E, Hagerman R, Hessl D, Vaidya D, Lozano R, Rosselot H, Erickson C, Kaufmann WE, Budimirovic DB. PMID: 32932789; PMCID: PMC7563217.
      View in: PubMed   Mentions: 13  
    33. FMR1 locus isoforms: potential biomarker candidates in fragile X-associated tremor/ataxia syndrome (FXTAS). Sci Rep. 2020 07 06; 10(1):11099. Zafarullah M, Tang HT, Durbin-Johnson B, Fourie E, Hessl D, Rivera SM, Tassone F. PMID: 32632326; PMCID: PMC7338407.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    34. Validation of the NIH Toolbox Cognitive Battery in intellectual disability. Neurology. 2020 03 24; 94(12):e1229-e1240. Shields RH, Kaat AJ, McKenzie FJ, Drayton A, Sansone SM, Coleman J, Michalak C, Riley K, Berry-Kravis E, Gershon RC, Widaman KF, Hessl D. PMID: 32094241; PMCID: PMC7274932.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    35. Association between IQ and FMR1 protein (FMRP) across the spectrum of CGG repeat expansions. PLoS One. 2019; 14(12):e0226811. Kim K, Hessl D, Randol JL, Espinal GM, Schneider A, Protic D, Aydin EY, Hagerman RJ, Hagerman PJ. PMID: 31891607; PMCID: PMC6938341.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    36. Interaction between ventricular expansion and structural changes in the corpus callosum and putamen in males with FMR1 normal and premutation alleles. Neurobiol Aging. 2020 02; 86:27-38. Wang JY, Hessl D, Tassone F, Kim K, Hagerman RJ, Rivera SM. PMID: 31733943; PMCID: PMC6995416.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    37. Cognitive training for children and adolescents with fragile X syndrome: a randomized controlled trial of Cogmed. J Neurodev Disord. 2019 04 15; 11(1):4. Hessl D, Schweitzer JB, Nguyen DV, McLennan YA, Johnston C, Shickman R, Chen Y. PMID: 30982467; PMCID: PMC6463634.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    38. Extending the Parent-Delivered Early Start Denver Model to Young Children with Fragile X Syndrome. J Autism Dev Disord. 2019 Mar; 49(3):1250-1266. Vismara LA, McCormick CEB, Shields R, Hessl D. PMID: 30499037.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    39. Voice of People with Fragile X Syndrome and Their Families: Reports from a Survey on Treatment Priorities. Brain Sci. 2019 Jan 23; 9(2). Weber JD, Smith E, Berry-Kravis E, Cadavid D, Hessl D, Erickson C. PMID: 30678024; PMCID: PMC6406416.
      View in: PubMed   Mentions: 20  
    40. Effects of mavoglurant on visual attention and pupil reactivity while viewing photographs of faces in Fragile X Syndrome. PLoS One. 2019; 14(1):e0209984. Hessl D, Harvey D, Sansone S, Crestodina C, Chin J, Joshi R, Hagerman RJ, Berry-Kravis E. PMID: 30653533; PMCID: PMC6336311.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    41. Executive Function in Fragile X Syndrome: A Systematic Review. Brain Sci. 2019 Jan 16; 9(1). Schmitt LM, Shaffer RC, Hessl D, Erickson C. PMID: 30654486; PMCID: PMC6356760.
      View in: PubMed   Mentions: 16  
    42. Best Practices in Fragile X Syndrome Treatment Development. Brain Sci. 2018 Dec 15; 8(12). Erickson CA, Kaufmann WE, Budimirovic DB, Lachiewicz A, Haas-Givler B, Miller RM, Weber JD, Abbeduto L, Hessl D, Hagerman RJ, Berry-Kravis E. PMID: 30558274; PMCID: PMC6315698.
      View in: PubMed   Mentions: 22  
    43. Presence of Middle Cerebellar Peduncle Sign in FMR1 Premutation Carriers Without Tremor and Ataxia. Front Neurol. 2018; 9:695. Famula JL, McKenzie F, McLennan YA, Grigsby J, Tassone F, Hessl D, Rivera SM, Martinez-Cerdeno V, Hagerman RJ. PMID: 30186228; PMCID: PMC6113389.
      View in: PubMed   Mentions: 12  
    44. Assessment of Molecular Measures in Non-FXTAS Male Premutation Carriers. Front Genet. 2018; 9:302. Al Olaby RR, Tang HT, Durbin-Johnson B, Schneider A, Hessl D, Rivera SM, Tassone F. PMID: 30186307; PMCID: PMC6113865.
      View in: PubMed   Mentions: 4  
    45. Middle Cerebellar Peduncle Width-A Novel MRI Biomarker for FXTAS? Front Neurosci. 2018; 12:379. Shelton AL, Wang JY, Fourie E, Tassone F, Chen A, Frizzi L, Hagerman RJ, Ferrer E, Hessl D, Rivera SM. PMID: 29988561; PMCID: PMC6026659.
      View in: PubMed   Mentions: 9  
    46. Computerized Cognitive Training in Children With Autism and Intellectual Disabilities: Feasibility and Satisfaction Study. JMIR Ment Health. 2018 May 25; 5(2):e40. Benyakorn S, Calub CA, Riley SJ, Schneider A, Iosif AM, Solomon M, Hessl D, Schweitzer JB. PMID: 29802090; PMCID: PMC5993974.
      View in: PubMed   Mentions: 8  
    47. Age- and CGG repeat-related slowing of manual movement in fragile X carriers: A prodrome of fragile X-associated tremor ataxia syndrome? Mov Disord. 2018 04; 33(4):628-636. Shickman R, Famula J, Tassone F, Leehey M, Ferrer E, Rivera SM, Hessl D. PMID: 29389022; PMCID: PMC5889332.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    48. Standardized Assessment Accommodations for Individuals with Intellectual Disability. Contemp Sch Psychol. 2018 Dec; 22(4):443-457. Thompson T, Coleman JM, Riley K, Snider LA, Howard LJ, Sansone SM, Hessl D. PMID: 30420939; PMCID: PMC6226246.
      View in: PubMed   Mentions: 8  
    49. Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome. Nat Rev Drug Discov. 2018 04; 17(4):280-299. Berry-Kravis EM, Lindemann L, Jønch AE, Apostol G, Bear MF, Carpenter RL, Crawley JN, Curie A, Des Portes V, Hossain F, Gasparini F, Gomez-Mancilla B, Hessl D, Loth E, Scharf SH, Wang PP, Von Raison F, Hagerman R, Spooren W, Jacquemont S. PMID: 29217836; PMCID: PMC6904225.
      View in: PubMed   Mentions: 149     Fields:    Translation:HumansAnimals
    50. Effect of the mGluR5-NAM Basimglurant on Behavior in Adolescents and Adults with Fragile X Syndrome in a Randomized, Double-Blind, Placebo-Controlled Trial: FragXis Phase 2 Results. Neuropsychopharmacology. 2018 02; 43(3):503-512. Youssef EA, Berry-Kravis E, Czech C, Hagerman RJ, Hessl D, Wong CY, Rabbia M, Deptula D, John A, Kinch R, Drewitt P, Lindemann L, Marcinowski M, Langland R, Horn C, Fontoura P, Santarelli L, Quiroz JA, FragXis Study Group. PMID: 28816242; PMCID: PMC5770759.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCellsCTClinical Trials
    51. A randomized double-blind, placebo-controlled trial of ganaxolone in children and adolescents with fragile X syndrome. J Neurodev Disord. 2017 Aug 02; 9(1):26. Ligsay A, Van Dijck A, Nguyen DV, Lozano R, Chen Y, Bickel ES, Hessl D, Schneider A, Angkustsiri K, Tassone F, Ceulemans B, Kooy RF, Hagerman RJ. PMID: 28764646; PMCID: PMC5540519.
      View in: PubMed   Mentions: 31     Fields:    
    52. Fragile X targeted pharmacotherapy: lessons learned and future directions. J Neurodev Disord. 2017; 9:7. Erickson CA, Davenport MH, Schaefer TL, Wink LK, Pedapati EV, Sweeney JA, Fitzpatrick SE, Brown WT, Budimirovic D, Hagerman RJ, Hessl D, Kaufmann WE, Berry-Kravis E. PMID: 28616096; PMCID: PMC5467059.
      View in: PubMed   Mentions: 63     Fields:    
    53. Updated report on tools to measure outcomes of clinical trials in fragile X syndrome. J Neurodev Disord. 2017; 9:14. Budimirovic DB, Berry-Kravis E, Erickson CA, Hall SS, Hessl D, Reiss AL, King MK, Abbeduto L, Kaufmann WE. PMID: 28616097; PMCID: PMC5467057.
      View in: PubMed   Mentions: 84     Fields:    
    54. Clinical and molecular correlates in fragile X premutation females. eNeurologicalSci. 2017 Jun; 7:49-56. Jiraanont P, Sweha SR, AlOlaby RR, Silva M, Tang HT, Durbin-Johnson B, Schneider A, Espinal GM, Hagerman PJ, Rivera SM, Hessl D, Hagerman RJ, Chutabhakdikul N, Tassone F. PMID: 28971146; PMCID: PMC5621595.
      View in: PubMed   Mentions: 6  
    55. Autism Spectrum Disorder in Males with Sex Chromosome Aneuploidy: XXY/Klinefelter Syndrome, XYY, and XXYY. J Dev Behav Pediatr. 2017 Apr; 38(3):197-207. Tartaglia NR, Wilson R, Miller JS, Rafalko J, Cordeiro L, Davis S, Hessl D, Ross J. PMID: 28333849; PMCID: PMC5423728.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    56. Abnormal trajectories in cerebellum and brainstem volumes in carriers of the fragile X premutation. Neurobiol Aging. 2017 07; 55:11-19. Wang JY, Hessl D, Hagerman RJ, Simon TJ, Tassone F, Ferrer E, Rivera SM. PMID: 28391068; PMCID: PMC5498112.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    57. A Randomized, Double-Blind, Placebo-Controlled Trial of Low-Dose Sertraline in Young Children With Fragile X Syndrome. J Dev Behav Pediatr. 2016 10; 37(8):619-28. Greiss Hess L, Fitzpatrick SE, Nguyen DV, Chen Y, Gaul KN, Schneider A, Lemons Chitwood K, Eldeeb MA, Polussa J, Hessl D, Rivera S, Hagerman RJ. PMID: 27560971; PMCID: PMC5039060.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    58. Aging in Fragile X Premutation Carriers. Cerebellum. 2016 10; 15(5):587-94. Lozano R, Saito N, Reed D, Eldeeb M, Schneider A, Hessl D, Tassone F, Beckett L, Hagerman R. PMID: 27334385; PMCID: PMC8020959.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    59. Psychiatric disorders among women with the fragile X premutation without children affected by fragile X syndrome. Am J Med Genet B Neuropsychiatr Genet. 2016 12; 171(8):1139-1147. Gossett A, Sansone S, Schneider A, Johnston C, Hagerman R, Tassone F, Rivera SM, Seritan AL, Hessl D. PMID: 27615674; PMCID: PMC6907071.
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    60. The NIH Toolbox Cognitive Battery for intellectual disabilities: three preliminary studies and future directions. J Neurodev Disord. 2016; 8(1):35. Hessl D, Sansone SM, Berry-Kravis E, Riley K, Widaman KF, Abbeduto L, Schneider A, Coleman J, Oaklander D, Rhodes KC, Gershon RC. PMID: 27602170; PMCID: PMC5012003.
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    61. Fragile X-associated tremor/ataxia syndrome: another phenotype of the fragile X gene. Clin Neuropsychol. 2016 Aug; 30(6):810-4. Hessl D, Grigsby J. PMID: 27355274; PMCID: PMC5002352.
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    62. Broad autism spectrum and obsessive-compulsive symptoms in adults with the fragile X premutation. Clin Neuropsychol. 2016 08; 30(6):929-43. Schneider A, Johnston C, Tassone F, Sansone S, Hagerman RJ, Ferrer E, Rivera SM, Hessl D. PMID: 27355445; PMCID: PMC5004987.
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    63. Robust Machine Learning-Based Correction on Automatic Segmentation of the Cerebellum and Brainstem. PLoS One. 2016; 11(5):e0156123. Wang JY, Ngo MM, Hessl D, Hagerman RJ, Rivera SM. PMID: 27213683; PMCID: PMC4877064.
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    64. The Autism Spectrum Disorders Stem Cell Resource at Children's Hospital of Orange County: Implications for Disease Modeling and Drug Discovery. Stem Cells Transl Med. 2015 Nov; 4(11):1369. Brick DJ, Nethercott HE, Montesano S, Banuelos MG, Stover AE, Schutte SS, O'Dowd DK, Hagerman RJ, Ono M, Hessl DR, Tassone F, Schwartz PH. PMID: 26508786; PMCID: PMC4622400.
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    65. Anxiety disorders in fragile X premutation carriers: Preliminary characterization of probands and non-probands. Intractable Rare Dis Res. 2015 Aug; 4(3):123-30. Cordeiro L, Abucayan F, Hagerman R, Tassone F, Hessl D. PMID: 26361563; PMCID: PMC4561241.
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    66. Emotion potentiated startle in fragile X syndrome. J Autism Dev Disord. 2014 Oct; 44(10):2536-46. Ballinger EC, Cordeiro L, Chavez AD, Hagerman RJ, Hessl D. PMID: 24816942; PMCID: PMC4167929.
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    67. The Autism Spectrum Disorders Stem Cell Resource at Children's Hospital of Orange County: Implications for Disease Modeling and Drug Discovery. Stem Cells Transl Med. 2014 Nov; 3(11):1275-86. Brick DJ, Nethercott HE, Montesano S, Banuelos MG, Stover AE, Schutte SS, O'Dowd DK, Hagerman RJ, Ono M, Hessl DR, Tassone F, Schwartz PH. PMID: 25273538; PMCID: PMC4214842.
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    68. A feasibility trial of Cogmed working memory training in fragile X syndrome. J Pediatr Genet. 2014 Sep; 3(3):147-56. Au J, Berkowitz-Sutherland L, Schneider A, Schweitzer JB, Hessl D, Hagerman R. PMID: 27625871; PMCID: PMC5021004.
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    69. Improving IQ measurement in intellectual disabilities using true deviation from population norms. J Neurodev Disord. 2014; 6(1):16. Sansone SM, Schneider A, Bickel E, Berry-Kravis E, Prescott C, Hessl D. PMID: 26491488; PMCID: PMC4613563.
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    70. Association between macroorchidism and intelligence in FMR1 premutation carriers. Am J Med Genet A. 2014 Sep; 164A(9):2206-11. Lozano R, Summers S, Lozano C, Mu Y, Hessl D, Nguyen D, Tassone F, Hagerman R. PMID: 24903624; PMCID: PMC4332881.
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    71. Electrodermal and behavioral responses of children with autism spectrum disorders to sensory and repetitive stimuli. Autism Res. 2014 Aug; 7(4):468-80. McCormick C, Hessl D, Macari SL, Ozonoff S, Green C, Rogers SJ. PMID: 24788961; PMCID: PMC6960008.
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    72. Psychological status in female carriers of premutation FMR1 allele showing a complex relationship with the size of CGG expansion. Clin Genet. 2015 Feb; 87(2):173-8. Loesch DZ, Bui MQ, Hammersley E, Schneider A, Storey E, Stimpson P, Burgess T, Francis D, Slater H, Tassone F, Hagerman RJ, Hessl D. PMID: 24428240; PMCID: PMC4115039.
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    73. Feasibility, reproducibility, and clinical validity of the pediatric anxiety rating scale-revised for fragile X syndrome. Am J Intellect Dev Disabil. 2014 Jan; 119(1):1-16. Russo-Ponsaran NM, Yesensky J, Hessl D, Berry-Kravis E. PMID: 24450318; PMCID: PMC6916720.
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    74. Anxiety, attention problems, hyperactivity, and the Aberrant Behavior Checklist in fragile X syndrome. Am J Med Genet A. 2014 Jan; 164A(1):141-55. Wheeler A, Raspa M, Bann C, Bishop E, Hessl D, Sacco P, Bailey DB. PMID: 24352914.
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    75. Psychophysiological responses to emotional stimuli in children and adolescents with autism and fragile X syndrome. J Clin Child Adolesc Psychol. 2015; 44(2):250-63. Cohen S, Masyn K, Mastergeorge A, Hessl D. PMID: 24156344; PMCID: PMC3999342.
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    76. Outcome measures for clinical trials in fragile X syndrome. J Dev Behav Pediatr. 2013 Sep; 34(7):508-22. Berry-Kravis E, Hessl D, Abbeduto L, Reiss AL, Beckel-Mitchener A, Urv TK, Outcome Measures Working Groups. PMID: 24042082; PMCID: PMC3784007.
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    77. Electrocortical changes associated with minocycline treatment in fragile X syndrome. J Psychopharmacol. 2013 Oct; 27(10):956-63. Schneider A, Leigh MJ, Adams P, Nanakul R, Chechi T, Olichney J, Hagerman R, Hessl D. PMID: 23981511; PMCID: PMC4962861.
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    78. Fragile X-associated tremor/ataxia syndrome: influence of the FMR1 gene on motor fiber tracts in males with normal and premutation alleles. JAMA Neurol. 2013 Aug; 70(8):1022-9. Wang JY, Hessl D, Schneider A, Tassone F, Hagerman RJ, Rivera SM. PMID: 23753897; PMCID: PMC4028037.
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    79. A family with two female siblings with compound heterozygous FMR1 premutation alleles. Clin Genet. 2014 May; 85(5):458-63. Basuta K, Lozano R, Schneider A, Yrigollen CM, Hessl D, Hagerman RJ, Tassone F. PMID: 23786467; PMCID: PMC3996450.
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    80. A randomized double-blind, placebo-controlled trial of minocycline in children and adolescents with fragile x syndrome. J Dev Behav Pediatr. 2013 Apr; 34(3):147-55. Leigh MJ, Nguyen DV, Mu Y, Winarni TI, Schneider A, Chechi T, Polussa J, Doucet P, Tassone F, Rivera SM, Hessl D, Hagerman RJ. PMID: 23572165; PMCID: PMC3706260.
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    81. FRAGILE X SYNDROME: PSYCHIATRIC MANIFESTATIONS, ASSESSMENT AND EMERGING THERAPIES. Curr Psychiatry Rev. 2013 Feb 01; 9(1):53-58. Wadell PM, Hagerman RJ, Hessl DR. PMID: 25632275; PMCID: PMC4306413.
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    82. Psychiatric features in high-functioning adult brothers with fragile x spectrum disorders. Prim Care Companion CNS Disord. 2013; 15(2). Schneider A, Seritan A, Tassone F, Rivera SM, Hagerman R, Hessl D. PMID: 23930232; PMCID: PMC3733525.
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    83. Fear-specific amygdala function in children and adolescents on the fragile x spectrum: a dosage response of the FMR1 gene. Cereb Cortex. 2014 Mar; 24(3):600-13. Kim SY, Burris J, Bassal F, Koldewyn K, Chattarji S, Tassone F, Hessl D, Rivera SM. PMID: 23146966; PMCID: PMC3920763.
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    84. Male carriers of the FMR1 premutation show altered hippocampal-prefrontal function during memory encoding. Front Hum Neurosci. 2012; 6:297. Wang JM, Koldewyn K, Hashimoto R, Schneider A, Le L, Tassone F, Cheung K, Hagerman P, Hessl D, Rivera SM. PMID: 23115550; PMCID: PMC3483622.
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    85. Influence of the fragile X mental retardation (FMR1) gene on the brain and working memory in men with normal FMR1 alleles. Neuroimage. 2013 Jan 15; 65:288-98. Wang JY, Hessl D, Iwahashi C, Cheung K, Schneider A, Hagerman RJ, Hagerman PJ, Rivera SM. PMID: 23063447; PMCID: PMC3540208.
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    86. Effects of STX209 (arbaclofen) on neurobehavioral function in children and adults with fragile X syndrome: a randomized, controlled, phase 2 trial. Sci Transl Med. 2012 Sep 19; 4(152):152ra127. Berry-Kravis EM, Hessl D, Rathmell B, Zarevics P, Cherubini M, Walton-Bowen K, Mu Y, Nguyen DV, Gonzalez-Heydrich J, Wang PP, Carpenter RL, Bear MF, Hagerman RJ. PMID: 22993294.
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    87. Psychometric study of the Aberrant Behavior Checklist in Fragile X Syndrome and implications for targeted treatment. J Autism Dev Disord. 2012 Jul; 42(7):1377-92. Sansone SM, Widaman KF, Hall SS, Reiss AL, Lightbody A, Kaufmann WE, Berry-Kravis E, Lachiewicz A, Brown EC, Hessl D. PMID: 21972117; PMCID: PMC3290710.
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    88. Hypertension in FMR1 premutation males with and without fragile X-associated tremor/ataxia syndrome (FXTAS). Am J Med Genet A. 2012 Jun; 158A(6):1304-9. Hamlin AA, Sukharev D, Campos L, Mu Y, Tassone F, Hessl D, Nguyen DV, Loesch D, Hagerman RJ. PMID: 22528549; PMCID: PMC3983689.
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    89. Age-dependent structural connectivity effects in fragile x premutation. Arch Neurol. 2012 Apr; 69(4):482-9. Wang JY, Hessl DH, Hagerman RJ, Tassone F, Rivera SM. PMID: 22491193; PMCID: PMC3979438.
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    90. Feasibility, reliability, and clinical validity of the Test of Attentional Performance for Children (KiTAP) in Fragile X syndrome (FXS). J Neurodev Disord. 2012 Feb 08; 4(1):2. Knox A, Schneider A, Abucayan F, Hervey C, Tran C, Hessl D, Berry-Kravis E. PMID: 22958782; PMCID: PMC3374289.
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    91. Investigation of amygdala volume in men with the fragile X premutation. Brain Imaging Behav. 2011 Dec; 5(4):285-94. Selmeczy D, Koldewyn K, Wang JM, Lee A, Harvey D, Hessl DR, Tassone F, Adams P, Hagerman RJ, Hagerman PJ, Rivera SM. PMID: 21786216; PMCID: PMC3982607.
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    92. Reliability of eye tracking and pupillometry measures in individuals with fragile X syndrome. J Autism Dev Disord. 2011 Nov; 41(11):1515-22. Farzin F, Scaggs F, Hervey C, Berry-Kravis E, Hessl D. PMID: 21267642; PMCID: PMC3196645.
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    93. Increased prevalence of seizures in boys who were probands with the FMR1 premutation and co-morbid autism spectrum disorder. Hum Genet. 2012 Apr; 131(4):581-9. Chonchaiya W, Au J, Schneider A, Hessl D, Harris SW, Laird M, Mu Y, Tassone F, Nguyen DV, Hagerman RJ. PMID: 22001913; PMCID: PMC4105134.
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    94. Decreased fragile X mental retardation protein expression underlies amygdala dysfunction in carriers of the fragile X premutation. Biol Psychiatry. 2011 Nov 01; 70(9):859-65. Hessl D, Wang JM, Schneider A, Koldewyn K, Le L, Iwahashi C, Cheung K, Tassone F, Hagerman PJ, Rivera SM. PMID: 21783174; PMCID: PMC3191264.
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    95. Brief report: Sensorimotor gating in idiopathic autism and autism associated with fragile X syndrome. J Autism Dev Disord. 2011 Feb; 41(2):248-53. Yuhas J, Cordeiro L, Tassone F, Ballinger E, Schneider A, Long JM, Ornitz EM, Hessl D. PMID: 20521090; PMCID: PMC3023021.
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    96. Clinical assessment of DSM-IV anxiety disorders in fragile X syndrome: prevalence and characterization. J Neurodev Disord. 2011 Mar; 3(1):57-67. Cordeiro L, Ballinger E, Hagerman R, Hessl D. PMID: 21475730; PMCID: PMC3057014.
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    97. Prepulse inhibition in patients with fragile X-associated tremor ataxia syndrome. Neurobiol Aging. 2012 Jun; 33(6):1045-53. Schneider A, Ballinger E, Chavez A, Tassone F, Hagerman RJ, Hessl D. PMID: 20961665; PMCID: PMC3044775.
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    98. Autoimmune disease in mothers with the FMR1 premutation is associated with seizures in their children with fragile X syndrome. Hum Genet. 2010 Nov; 128(5):539-48. Chonchaiya W, Tassone F, Ashwood P, Hessl D, Schneider A, Campos L, Nguyen DV, Hagerman RJ. PMID: 20809278; PMCID: PMC2955238.
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    99. Lifetime prevalence of mood and anxiety disorders in fragile X premutation carriers. J Clin Psychiatry. 2011 Feb; 72(2):175-82. Bourgeois JA, Seritan AL, Casillas EM, Hessl D, Schneider A, Yang Y, Kaur I, Cogswell JB, Nguyen DV, Hagerman RJ. PMID: 20816038; PMCID: PMC4038118.
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    100. Aging in fragile X syndrome. J Neurodev Disord. 2010 Jun; 2(2):70-76. Utari A, Adams E, Berry-Kravis E, Chavez A, Scaggs F, Ngotran L, Boyd A, Hessl D, Gane LW, Tassone F, Tartaglia N, Leehey MA, Hagerman RJ. PMID: 20585378; PMCID: PMC2882562.
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    101. Psychological symptoms correlate with reduced hippocampal volume in fragile X premutation carriers. Am J Med Genet B Neuropsychiatr Genet. 2010 Apr 05; 153B(3):775-85. Adams PE, Adams JS, Nguyen DV, Hessl D, Brunberg JA, Tassone F, Zhang W, Koldewyn K, Rivera SM, Grigsby J, Zhang L, Decarli C, Hagerman PJ, Hagerman RJ. PMID: 19908235; PMCID: PMC2868927.
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    102. Plasma cytokine profiles in Fragile X subjects: is there a role for cytokines in the pathogenesis? Brain Behav Immun. 2010 Aug; 24(6):898-902. Ashwood P, Nguyen DV, Hessl D, Hagerman RJ, Tassone F. PMID: 20102735; PMCID: PMC3626458.
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    103. Broad clinical involvement in a family affected by the fragile X premutation. J Dev Behav Pediatr. 2009 Dec; 30(6):544-51. Chonchaiya W, Utari A, Pereira GM, Tassone F, Hessl D, Hagerman RJ. PMID: 19996900; PMCID: PMC2822648.
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    104. Prepulse inhibition in fragile X syndrome: feasibility, reliability, and implications for treatment. Am J Med Genet B Neuropsychiatr Genet. 2009 Jun 05; 150B(4):545-53. Hessl D, Berry-Kravis E, Cordeiro L, Yuhas J, Ornitz EM, Campbell A, Chruscinski E, Hervey C, Long JM, Hagerman RJ. PMID: 18785205; PMCID: PMC2693303.
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    105. A review of fragile X premutation disorders: expanding the psychiatric perspective. J Clin Psychiatry. 2009 Jun; 70(6):852-62. Bourgeois JA, Coffey SM, Rivera SM, Hessl D, Gane LW, Tassone F, Greco C, Finucane B, Nelson L, Berry-Kravis E, Grigsby J, Hagerman PJ, Hagerman RJ. PMID: 19422761; PMCID: PMC2705685.
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    106. Brief report: Visual processing of faces in individuals with fragile X syndrome: an eye tracking study. J Autism Dev Disord. 2009 Jun; 39(6):946-52. Farzin F, Rivera SM, Hessl D. PMID: 19399604; PMCID: PMC2684976.
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    107. A solution to limitations of cognitive testing in children with intellectual disabilities: the case of fragile X syndrome. J Neurodev Disord. 2009 Mar; 1(1):33-45. Hessl D, Nguyen DV, Green C, Chavez A, Tassone F, Hagerman RJ, Senturk D, Schneider A, Lightbody A, Reiss AL, Hall S. PMID: 19865612; PMCID: PMC2768415.
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    108. Towards a neurodevelopmental model of clinical case formulation. Psychiatr Clin North Am. 2009 Mar; 32(1):199-211. Solomon M, Hessl D, Chiu S, Olsen E, Hendren RL. PMID: 19248925; PMCID: PMC2692218.
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    109. A pilot open label, single dose trial of fenobam in adults with fragile X syndrome. J Med Genet. 2009 Apr; 46(4):266-71. Berry-Kravis E, Hessl D, Coffey S, Hervey C, Schneider A, Yuhas J, Hutchison J, Snape M, Tranfaglia M, Nguyen DV, Hagerman R. PMID: 19126569; PMCID: PMC2658751.
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    110. Fragile X syndrome -- from genes to cognition. Dev Disabil Res Rev. 2009; 15(4):333-42. Schneider A, Hagerman RJ, Hessl D. PMID: 20014363.
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    111. Advances in the treatment of fragile X syndrome. Pediatrics. 2009 Jan; 123(1):378-90. Hagerman RJ, Berry-Kravis E, Kaufmann WE, Ono MY, Tartaglia N, Lachiewicz A, Kronk R, Delahunty C, Hessl D, Visootsak J, Picker J, Gane L, Tranfaglia M. PMID: 19117905; PMCID: PMC2888470.
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    112. Autism profiles of males with fragile X syndrome. Am J Ment Retard. 2008 Nov; 113(6):427-38. Harris SW, Hessl D, Goodlin-Jones B, Ferranti J, Bacalman S, Barbato I, Tassone F, Hagerman PJ, Herman H, Hagerman RJ. PMID: 19127654; PMCID: PMC2629645.
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    113. Motor abilities of children diagnosed with fragile X syndrome with and without autism. J Intellect Disabil Res. 2009 Jan; 53(1):11-8. Zingerevich C, Greiss-Hess L, Lemons-Chitwood K, Harris SW, Hessl D, Cook K, Hagerman RJ. PMID: 18771512; PMCID: PMC2614297.
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    114. Secondary medical diagnosis in fragile X syndrome with and without autism spectrum disorder. Am J Med Genet A. 2008 Aug 01; 146A(15):1911-6. García-Nonell C, Ratera ER, Harris S, Hessl D, Ono MY, Tartaglia N, Marvin E, Tassone F, Hagerman RJ. PMID: 18627038; PMCID: PMC4097171.
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    115. Altered hypothalamus-pituitary-adrenal gland axis regulation in the expanded CGG-repeat mouse model for fragile X-associated tremor/ataxia syndrome. Psychoneuroendocrinology. 2008 Jul; 33(6):863-73. Brouwer JR, Severijnen E, de Jong FH, Hessl D, Hagerman RJ, Oostra BA, Willemsen R. PMID: 18472227; PMCID: PMC4408208.
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    116. Abnormal nerve conduction features in fragile X premutation carriers. Arch Neurol. 2008 Apr; 65(4):495-8. Soontarapornchai K, Maselli R, Fenton-Farrell G, Tassone F, Hagerman PJ, Hessl D, Hagerman RJ. PMID: 18413472; PMCID: PMC2888466.
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    117. The primary cognitive deficit among males with fragile X-associated tremor/ataxia syndrome (FXTAS) is a dysexecutive syndrome. J Clin Exp Neuropsychol. 2008 Nov; 30(8):853-69. Brega AG, Goodrich G, Bennett RE, Hessl D, Engle K, Leehey MA, Bounds LS, Paulich MJ, Hagerman RJ, Hagerman PJ, Cogswell JB, Tassone F, Reynolds A, Kooken R, Kenny M, Grigsby J. PMID: 18608667; PMCID: PMC4098148.
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    118. Reduced Hippocampal Activation During Recall is Associated with Elevated FMR1 mRNA and Psychiatric Symptoms in Men with the Fragile X Premutation. Brain Imaging Behav. 2008 Jan 18; 2(2):105-116. Koldewyn K, Hessl D, Adams J, Tassone F, Hagerman PJ, Hagerman RJ, Rivera SM. PMID: 19430586; PMCID: PMC2678852.
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    119. Cognitive profile of fragile X premutation carriers with and without fragile X-associated tremor/ataxia syndrome. Neuropsychology. 2008 Jan; 22(1):48-60. Grigsby J, Brega AG, Engle K, Leehey MA, Hagerman RJ, Tassone F, Hessl D, Hagerman PJ, Cogswell JB, Bennett RE, Cook K, Hall DA, Bounds LS, Paulich MJ, Reynolds A. PMID: 18211155.
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    120. Cognitive, anxiety and mood disorders in the fragile X-associated tremor/ataxia syndrome. Gen Hosp Psychiatry. 2007 Jul-Aug; 29(4):349-56. Bourgeois JA, Cogswell JB, Hessl D, Zhang L, Ono MY, Tassone F, Farzin F, Brunberg JA, Grigsby J, Hagerman RJ. PMID: 17591512; PMCID: PMC3991490.
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    121. Recommendations from multi-disciplinary focus groups on cascade testing and genetic counseling for fragile X-associated disorders. J Genet Couns. 2007 Oct; 16(5):593-606. McConkie-Rosell A, Abrams L, Finucane B, Cronister A, Gane LW, Coffey SM, Sherman S, Nelson LM, Berry-Kravis E, Hessl D, Chiu S, Street N, Vatave A, Hagerman RJ. PMID: 17497108.
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    122. Impairment of executive cognitive functioning in males with fragile X-associated tremor/ataxia syndrome. Mov Disord. 2007 Apr 15; 22(5):645-50. Grigsby J, Brega AG, Leehey MA, Goodrich GK, Jacquemont S, Loesch DZ, Cogswell JB, Epstein J, Wilson R, Jardini T, Gould E, Bennett RE, Hessl D, Cohen S, Cook K, Tassone F, Hagerman PJ, Hagerman RJ. PMID: 17266074.
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    123. A genetic etiology of pervasive developmental disorder guides treatment. Am J Psychiatry. 2007 Apr; 164(4):575-80. Solomon M, Hessl D, Chiu S, Hagerman R, Hendren R. PMID: 17403969.
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    124. Brief report: aggression and stereotypic behavior in males with fragile X syndrome--moderating secondary genes in a "single gene" disorder. J Autism Dev Disord. 2008 Jan; 38(1):184-9. Hessl D, Tassone F, Cordeiro L, Koldewyn K, McCormick C, Green C, Wegelin J, Yuhas J, Hagerman RJ. PMID: 17340199.
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    125. Early acceleration of head circumference in children with fragile x syndrome and autism. J Dev Behav Pediatr. 2007 Feb; 28(1):31-5. Chiu S, Wegelin JA, Blank J, Jenkins M, Day J, Hessl D, Tassone F, Hagerman R. PMID: 17353729.
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    126. Progression of tremor and ataxia in male carriers of the FMR1 premutation. Mov Disord. 2007 Jan 15; 22(2):203-6. Leehey MA, Berry-Kravis E, Min SJ, Hall DA, Rice CD, Zhang L, Grigsby J, Greco CM, Reynolds A, Lara R, Cogswell J, Jacquemont S, Hessl DR, Tassone F, Hagerman R, Hagerman PJ. PMID: 17133502.
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    127. Amygdala dysfunction in men with the fragile X premutation. Brain. 2007 Feb; 130(Pt 2):404-16. Hessl D, Rivera S, Koldewyn K, Cordeiro L, Adams J, Tassone F, Hagerman PJ, Hagerman RJ. PMID: 17166860.
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    128. Molecular and cognitive predictors of the continuum of autistic behaviours in fragile X. Neurosci Biobehav Rev. 2007; 31(3):315-26. Loesch DZ, Bui QM, Dissanayake C, Clifford S, Gould E, Bulhak-Paterson D, Tassone F, Taylor AK, Hessl D, Hagerman R, Huggins RM. PMID: 17097142; PMCID: PMC2145511.
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    129. Molecular and imaging correlates of the fragile X-associated tremor/ataxia syndrome. Neurology. 2006 Oct 24; 67(8):1426-31. Cohen S, Masyn K, Adams J, Hessl D, Rivera S, Tassone F, Brunberg J, DeCarli C, Zhang L, Cogswell J, Loesch D, Leehey M, Grigsby J, Hagerman PJ, Hagerman R. PMID: 17060569.
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    130. Social behavior and cortisol reactivity in children with fragile X syndrome. J Child Psychol Psychiatry. 2006 Jun; 47(6):602-10. Hessl D, Glaser B, Dyer-Friedman J, Reiss AL. PMID: 16712637.
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    131. Autism spectrum disorders and attention-deficit/hyperactivity disorder in boys with the fragile X premutation. J Dev Behav Pediatr. 2006 Apr; 27(2 Suppl):S137-44. Farzin F, Perry H, Hessl D, Loesch D, Cohen J, Bacalman S, Gane L, Tassone F, Hagerman P, Hagerman R. PMID: 16685180.
      View in: PubMed   Mentions: 169     Fields:    Translation:HumansCells
    132. Dementia with mood symptoms in a fragile X premutation carrier with the fragile X-associated tremor/ataxia syndrome: clinical intervention with donepezil and venlafaxine. J Neuropsychiatry Clin Neurosci. 2006; 18(2):171-7. Bourgeois JA, Farzin F, Brunberg JA, Tassone F, Hagerman P, Zhang L, Hessl D, Hagerman R. PMID: 16720793.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    133. Neuropathology of fragile X-associated tremor/ataxia syndrome (FXTAS). Brain. 2006 Jan; 129(Pt 1):243-55. Greco CM, Berman RF, Martin RM, Tassone F, Schwartz PH, Chang A, Trapp BD, Iwahashi C, Brunberg J, Grigsby J, Hessl D, Becker EJ, Papazian J, Leehey MA, Hagerman RJ, Hagerman PJ. PMID: 16332642.
      View in: PubMed   Mentions: 262     Fields:    Translation:HumansCells
    134. Abnormal elevation of FMR1 mRNA is associated with psychological symptoms in individuals with the fragile X premutation. Am J Med Genet B Neuropsychiatr Genet. 2005 Nov 05; 139B(1):115-21. Hessl D, Tassone F, Loesch DZ, Berry-Kravis E, Leehey MA, Gane LW, Barbato I, Rice C, Gould E, Hall DA, Grigsby J, Wegelin JA, Harris S, Lewin F, Weinberg D, Hagerman PJ, Hagerman RJ. PMID: 16184602.
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    135. GRAND ROUNDS: an atypical progressive dementia in a male carrier of the fragile X premutation: an example of fragile X-associated tremor/ataxia syndrome. Appl Neuropsychol. 2005; 12(3):169-78. Mothersead PK, Conrad K, Hagerman RJ, Greco CM, Hessl D, Tassone F. PMID: 16131344.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    136. Fragile-X-associated tremor/ataxia syndrome (FXTAS) in females with the FMR1 premutation. Am J Hum Genet. 2004 May; 74(5):1051-6. Hagerman RJ, Leavitt BR, Farzin F, Jacquemont S, Greco CM, Brunberg JA, Tassone F, Hessl D, Harris SW, Zhang L, Jardini T, Gane LW, Ferranti J, Ruiz L, Leehey MA, Grigsby J, Hagerman PJ. PMID: 15065016; PMCID: PMC1181968.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansCells
    137. The neuroanatomy and neuroendocrinology of fragile X syndrome. Ment Retard Dev Disabil Res Rev. 2004; 10(1):17-24. Hessl D, Rivera SM, Reiss AL. PMID: 14994284.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    138. Factors associated with parenting stress in mothers of children with fragile X syndrome. J Dev Behav Pediatr. 2003 Aug; 24(4):267-75. Johnston C, Hessl D, Blasey C, Eliez S, Erba H, Dyer-Friedman J, Glaser B, Reiss AL. PMID: 12915799.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    139. Preschool outcomes of children of depressed mothers: role of maternal behavior, contextual risk, and children's brain activity. Child Dev. 2003 Jul-Aug; 74(4):1158-75. Dawson G, Ashman SB, Panagiotides H, Hessl D, Self J, Yamada E, Embry L. PMID: 12938711.
      View in: PubMed   Mentions: 61     Fields:    Translation:Humans
    140. Biological and environmental contributions to adaptive behavior in fragile X syndrome. Am J Med Genet A. 2003 Feb 15; 117A(1):21-9. Glaser B, Hessl D, Dyer-Friedman J, Johnston C, Wisbeck J, Taylor A, Reiss A. PMID: 12548736.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    141. Cortisol and behavior in fragile X syndrome. Psychoneuroendocrinology. 2002 Oct; 27(7):855-72. Hessl D, Glaser B, Dyer-Friedman J, Blasey C, Hastie T, Gunnar M, Reiss AL. PMID: 12183220.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    142. Diurnal salivary cortisol in pediatric posttraumatic stress disorder. Biol Psychiatry. 2002 Apr 01; 51(7):575-82. Carrion VG, Weems CF, Ray RD, Glaser B, Hessl D, Reiss AL. PMID: 11950459.
      View in: PubMed   Mentions: 81     Fields:    Translation:Humans
    143. Genetic and environmental influences on the cognitive outcomes of children with fragile X syndrome. J Am Acad Child Adolesc Psychiatry. 2002 Mar; 41(3):237-44. Dyer-Friedman J, Glaser B, Hessl D, Johnston C, Huffman LC, Taylor A, Wisbeck J, Reiss AL. PMID: 11886017.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    144. fMRI study of cognitive interference processing in females with fragile X syndrome. J Cogn Neurosci. 2002 Feb 15; 14(2):160-71. Tamm L, Menon V, Johnston CK, Hessl DR, Reiss AL. PMID: 11970783.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    145. Neurobehavioral phenotype in carriers of the fragile X premutation. Am J Med Genet. 2001 Nov 01; 103(4):314-9. Johnston C, Eliez S, Dyer-Friedman J, Hessl D, Glaser B, Blasey C, Taylor A, Reiss A. PMID: 11746012.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    146. The influence of environmental and genetic factors on behavior problems and autistic symptoms in boys and girls with fragile X syndrome. Pediatrics. 2001 Nov; 108(5):E88. Hessl D, Dyer-Friedman J, Glaser B, Wisbeck J, Barajas RG, Taylor A, Reiss AL. PMID: 11694672.
      View in: PubMed   Mentions: 82     Fields:    Translation:Humans
    147. Infants of depressed mothers exhibit atypical frontal electrical brain activity during interactions with mother and with a familiar, nondepressed adult. Child Dev. 1999 Sep-Oct; 70(5):1058-66. Dawson G, Frey K, Panagiotides H, Yamada E, Hessl D, Osterling J. PMID: 10546334.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    148. Frontal brain electrical activity in infants of depressed and nondepressed mothers: relation to variations in infant behavior. Dev Psychopathol. 1999; 11(3):589-605. Dawson G, Frey K, Self J, Panagiotides H, Hessl D, Yamada E, Rinaldi J. PMID: 10532626.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    149. Infants of depressed mothers exhibit atypical frontal brain activity: a replication and extension of previous findings. J Child Psychol Psychiatry. 1997 Feb; 38(2):179-86. Dawson G, Frey K, Panagiotides H, Osterling J, Hessl D. PMID: 9232464.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
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