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Paul J Hagerman

Title(s)Professor, Biochemistry and Molecular Medicine
SchoolUniversity of California, Davis
Phone530-754-7266
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    Collapse Research 
    Collapse Research Activities and Funding
    Epigenetic regulation of the FMR1 gene
    NIH/NIGMS R01GM113929Sep 21, 2015 - May 31, 2019
    Role: Principal Investigator
    Human iPSC neuronal models for early and late phases of FXTAS neurodegeneration
    NIH/NIA RC1AG036022Sep 30, 2009 - Aug 31, 2011
    Role: Principal Investigator
    Development of targeted therapeutic agents for the treatment of FXTAS (2 of 6)
    NIH/NIA RL1AG032119Sep 30, 2007 - Jun 30, 2012
    Role: Principal Investigator
    Neuro Therapeutics Research Institute (1 of 6)
    NIH/NIDCR UL1DE019583Sep 15, 2007 - Jun 30, 2012
    Role: Principal Investigator
    Neuro Therapeutics Research Institute
    NIH/NCRR UL1RR024922Sep 15, 2007 - Jun 30, 2012
    Role: Principal Investigator
    Fragile X-associated Tremor/Ataxia Syndrome
    NIH/NIA R01AG024488Jun 15, 2005 - May 31, 2011
    Role: Principal Investigator
    Neurological Phenotype in FMR1 Premutation Carriers
    NIH/NINDS R01NS043532Jul 1, 2002 - Jun 30, 2006
    Role: Principal Investigator
    Expression of the fragile X gene
    NIH/NICHD R01HD040661Apr 1, 2002 - Dec 31, 2016
    Role: Principal Investigator
    TRNA STRUCTURE IN SOLUTION
    NIH/NIGMS R01GM052557Aug 1, 1996 - Jul 31, 2001
    Role: Principal Investigator
    PROTEIN NUCLEIC ACID INTERACTIONS
    NIH/NIGMS R01GM035305Jul 1, 1985 - Jun 30, 2004
    Role: Principal Investigator
    FLEXIBILITY OF DNA
    NIH/NIGMS R01GM028293Jul 1, 1980 - Jun 30, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ma L, Herren AW, Espinal G, Randol J, McLaughlin B, Martinez-Cerdeño V, Pessah IN, Hagerman RJ, Hagerman PJ. Composition of the Intranuclear Inclusions of Fragile X-associated Tremor/Ataxia Syndrome. Acta Neuropathol Commun. 2019 Sep 03; 7(1):143. PMID: 31481131.
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    2. Wenzel HJ, Murray KD, Haify SN, Hunsaker MR, Schwartzer JJ, Kim K, La Spada AR, Sopher BL, Hagerman PJ, Raske C, Severijnen LWFM, Willemsen R, Hukema RK, Berman RF. Astroglial-targeted expression of the fragile X CGG repeat premutation in mice yields RAN translation, motor deficits and possible evidence for cell-to-cell propagation of FXTAS pathology. Acta Neuropathol Commun. 2019 Feb 26; 7(1):27. PMID: 30808398.
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    3. Martínez Cerdeño V, Hong T, Amina S, Lechpammer M, Ariza J, Tassone F, Noctor SC, Hagerman P, Hagerman R. Microglial cell activation and senescence are characteristic of the pathology FXTAS. Mov Disord. 2018 12; 33(12):1887-1894. PMID: 30537011.
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    4. Ramírez-Cheyne JA, Duque GA, Ayala-Zapata S, Saldarriaga-Gil W, Hagerman P, Hagerman R, Payán-Gómez C. Fragile X syndrome and connective tissue dysregulation. Clin Genet. 2019 Feb; 95(2):262-267. PMID: 30414172.
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    5. Jiraanont P, Kumar M, Tang HT, Espinal G, Hagerman PJ, Hagerman RJ, Chutabhakdikul N, Tassone F. Size and methylation mosaicism in males with Fragile X syndrome. Expert Rev Mol Diagn. 2017 11; 17(11):1023-1032. PMID: 28929824.
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    6. Hagerman RJ, Berry-Kravis E, Hazlett HC, Bailey DB, Moine H, Kooy RF, Tassone F, Gantois I, Sonenberg N, Mandel JL, Hagerman PJ. Fragile X syndrome. Nat Rev Dis Primers. 2017 Sep 29; 3:17065. PMID: 28960184.
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    7. Lechpammer M, Martínez Cerdeno V, Hunsaker MR, Hah M, Gonzales H, Tisch S, Joffe R, Pamphlett R, Tassone F, Hagerman PJ, Bolitho SJ, Hagerman RJ. Concomitant occurrence of FXTAS and clinically defined sporadic inclusion body myositis: report of two cases. Croat Med J. 2017 Aug 31; 58(4):310-315. PMID: 28857524.
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    8. Robin G, López JR, Espinal GM, Hulsizer S, Hagerman PJ, Pessah IN. Calcium dysregulation and Cdk5-ATM pathway involved in a mouse model of fragile X-associated tremor/ataxia syndrome. Hum Mol Genet. 2017 07 15; 26(14):2649-2666. PMID: 28444183.
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    9. Martínez-Cerdeño V, Lechpammer M, Hagerman PJ, Hagerman R. Two FMR1 premutation cases without nuclear inclusions. Mov Disord. 2017 09; 32(9):1328-1329. PMID: 28568317.
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    10. Jiraanont P, Sweha SR, AlOlaby RR, Silva M, Tang HT, Durbin-Johnson B, Schneider A, Espinal GM, Hagerman PJ, Rivera SM, Hessl D, Hagerman RJ, Chutabhakdikul N, Tassone F. Clinical and molecular correlates in fragile X premutation females. eNeurologicalSci. 2017 Jun; 7:49-56. PMID: 28971146.
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    11. Martínez-Cerdeño V, Lechpammer M, Noctor S, Ariza J, Hagerman P, Hagerman R. FMR1 premutation with Prader-Willi phenotype and fragile X-associated tremor/ataxia syndrome. Clin Case Rep. 2017 05; 5(5):625-629. PMID: 28469864.
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    12. Ariza J, Rogers H, Hartvigsen A, Snell M, Dill M, Judd D, Hagerman P, Martínez-Cerdeño V. Iron accumulation and dysregulation in the putamen in fragile X-associated tremor/ataxia syndrome. Mov Disord. 2017 04; 32(4):585-591. PMID: 28233916.
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    13. Rogers H, Ariza J, Monterrubio A, Hagerman P, Martínez-Cerdeño V. Cerebellar Mild Iron Accumulation in a Subset of FMR1 Premutation Carriers with FXTAS. Cerebellum. 2016 10; 15(5):641-4. PMID: 27259564.
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    14. Ariza J, Rogers H, Monterrubio A, Reyes-Miranda A, Hagerman PJ, Martínez-Cerdeño V. A Majority of FXTAS Cases Present with Intranuclear Inclusions Within Purkinje Cells. Cerebellum. 2016 10; 15(5):546-51. PMID: 27108270.
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    15. Hagerman RJ, Hagerman P. Fragile X-associated tremor/ataxia syndrome - features, mechanisms and management. Nat Rev Neurol. 2016 07; 12(7):403-12. PMID: 27340021.
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    16. Kashima R, Roy S, Ascano M, Martinez-Cerdeno V, Ariza-Torres J, Kim S, Louie J, Lu Y, Leyton P, Bloch KD, Kornberg TB, Hagerman PJ, Hagerman R, Lagna G, Hata A. Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome. Sci Signal. 2016 06 07; 9(431):ra58. PMID: 27273096.
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    17. Pham TT, Yin J, Eid JS, Adams E, Lam R, Turner SW, Loomis EW, Wang JY, Hagerman PJ, Hanes JW. Single-locus enrichment without amplification for sequencing and direct detection of epigenetic modifications. Mol Genet Genomics. 2016 Jun; 291(3):1491-504. PMID: 26825750.
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    18. Hukema RK, Buijsen RA, Schonewille M, Raske C, Severijnen LA, Nieuwenhuizen-Bakker I, Verhagen RF, van Dessel L, Maas A, Charlet-Berguerand N, De Zeeuw CI, Hagerman PJ, Berman RF, Willemsen R. Reversibility of neuropathology and motor deficits in an inducible mouse model for FXTAS. Hum Mol Genet. 2015 Sep 01; 24(17):4948-57. PMID: 26060190.
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    19. Hagerman PJ, Hagerman RJ. Fragile X-associated tremor/ataxia syndrome. Ann N Y Acad Sci. 2015 Mar; 1338:58-70. PMID: 25622649.
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    20. Ariza J, Steward C, Rueckert F, Widdison M, Coffman R, Afjei A, Noctor SC, Hagerman R, Hagerman P, Martínez-Cerdeño V. Dysregulated iron metabolism in the choroid plexus in fragile X-associated tremor/ataxia syndrome. Brain Res. 2015 Feb 19; 1598:88-96. PMID: 25498860.
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    21. Pretto DI, Eid JS, Yrigollen CM, Tang HT, Loomis EW, Raske C, Durbin-Johnson B, Hagerman PJ, Tassone F. Differential increases of specific FMR1 mRNA isoforms in premutation carriers. J Med Genet. 2015 Jan; 52(1):42-52. PMID: 25358671.
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    22. Pretto D, Yrigollen CM, Tang HT, Williamson J, Espinal G, Iwahashi CK, Durbin-Johnson B, Hagerman RJ, Hagerman PJ, Tassone F. Clinical and molecular implications of mosaicism in FMR1 full mutations. Front Genet. 2014; 5:318. PMID: 25278957.
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    23. Yang JC, Chi L, Teichholtz S, Schneider A, Nanakul R, Nowacki R, Seritan A, Reed B, DeCarli C, Iragui VJ, Kutas M, Hagerman PJ, Hagerman RJ, Olichney JM. ERP abnormalities elicited by word repetition in fragile X-associated tremor/ataxia syndrome (FXTAS) and amnestic MCI. Neuropsychologia. 2014 Oct; 63:34-42. PMID: 25111034.
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    24. Tassone F, Hagerman PJ, Hagerman RJ. Fragile x premutation. J Neurodev Disord. 2014; 6(1):22. PMID: 25170346.
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    25. Sahdeo S, Tomilov A, Komachi K, Iwahashi C, Datta S, Hughes O, Hagerman P, Cortopassi G. High-throughput screening of FDA-approved drugs using oxygen biosensor plates reveals secondary mitofunctional effects. Mitochondrion. 2014 Jul; 17:116-25. PMID: 25034306.
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    26. Yang JC, Niu YQ, Simon C, Seritan AL, Chen L, Schneider A, Moghaddam ST, Hagerman PJ, Hagerman RJ, Olichney JM. Memantine effects on verbal memory in fragile X-associated tremor/ataxia syndrome (FXTAS): a double-blind brain potential study. Neuropsychopharmacology. 2014 Nov; 39(12):2760-8. PMID: 24871547.
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    27. Juang BT, Ludwig AL, Benedetti KL, Gu C, Collins K, Morales C, Asundi A, Wittmann T, L'Etoile N, Hagerman PJ. Expression of an expanded CGG-repeat RNA in a single pair of primary sensory neurons impairs olfactory adaptation in Caenorhabditis elegans. Hum Mol Genet. 2014 Sep 15; 23(18):4945-59. PMID: 24821701.
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    28. Loomis EW, Sanz LA, Chédin F, Hagerman PJ. Transcription-associated R-loop formation across the human FMR1 CGG-repeat region. PLoS Genet. 2014 Apr; 10(4):e1004294. PMID: 24743386.
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    29. Seritan AL, Nguyen DV, Mu Y, Tassone F, Bourgeois JA, Schneider A, Cogswell JB, Cook KR, Leehey MA, Grigsby J, Olichney JM, Adams PE, Legg W, Zhang L, Hagerman PJ, Hagerman RJ. Memantine for fragile X-associated tremor/ataxia syndrome: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2014 Mar; 75(3):264-71. PMID: 24345444.
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    30. Ludwig AL, Espinal GM, Pretto DI, Jamal AL, Arque G, Tassone F, Berman RF, Hagerman PJ. CNS expression of murine fragile X protein (FMRP) as a function of CGG-repeat size. Hum Mol Genet. 2014 Jun 15; 23(12):3228-38. PMID: 24463622.
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    31. Hukema RK, Buijsen RA, Raske C, Severijnen LA, Nieuwenhuizen-Bakker I, Minneboo M, Maas A, de Crom R, Kros JM, Hagerman PJ, Berman RF, Willemsen R. Induced expression of expanded CGG RNA causes mitochondrial dysfunction in vivo. Cell Cycle. 2014; 13(16):2600-8. PMID: 25486200.
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    32. Yang JC, Simon C, Schneider A, Seritan AL, Hamilton L, Hagerman PJ, Hagerman RJ, Olichney JM. Abnormal semantic processing in females with fragile X-associated tremor/ataxia syndrome. Genes Brain Behav. 2014 Feb; 13(2):152-62. PMID: 24299169.
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    33. Hagerman R, Hagerman P. Advances in clinical and molecular understanding of the FMR1 premutation and fragile X-associated tremor/ataxia syndrome. Lancet Neurol. 2013 Aug; 12(8):786-98. PMID: 23867198.
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    34. Yang JC, Simon C, Niu YQ, Bogost M, Schneider A, Tassone F, Seritan A, Grigsby J, Hagerman PJ, Hagerman RJ, Olichney JM. Phenotypes of hypofrontality in older female fragile X premutation carriers. Ann Neurol. 2013 Aug; 74(2):275-83. PMID: 23686745.
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    35. Hagerman P. Fragile X-associated tremor/ataxia syndrome (FXTAS): pathology and mechanisms. Acta Neuropathol. 2013 Jul; 126(1):1-19. PMID: 23793382.
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    36. Pretto DI, Hunsaker MR, Cunningham CL, Greco CM, Hagerman RJ, Noctor SC, Hall DA, Hagerman PJ, Tassone F. Intranuclear inclusions in a fragile X mosaic male. Transl Neurodegener. 2013 May 21; 2(1):10. PMID: 23692864.
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    37. Cao Z, Hulsizer S, Cui Y, Pretto DL, Kim KH, Hagerman PJ, Tassone F, Pessah IN. Enhanced asynchronous Ca(2+) oscillations associated with impaired glutamate transport in cortical astrocytes expressing Fmr1 gene premutation expansion. J Biol Chem. 2013 May 10; 288(19):13831-41. PMID: 23553633.
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    38. Sellier C, Freyermuth F, Tabet R, Tran T, He F, Ruffenach F, Alunni V, Moine H, Thibault C, Page A, Tassone F, Willemsen R, Disney MD, Hagerman PJ, Todd PK, Charlet-Berguerand N. Sequestration of DROSHA and DGCR8 by expanded CGG RNA repeats alters microRNA processing in fragile X-associated tremor/ataxia syndrome. Cell Rep. 2013 Mar 28; 3(3):869-80. PMID: 23478018.
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    39. Wang JM, Koldewyn K, Hashimoto R, Schneider A, Le L, Tassone F, Cheung K, Hagerman P, Hessl D, Rivera SM. Male carriers of the FMR1 premutation show altered hippocampal-prefrontal function during memory encoding. Front Hum Neurosci. 2012; 6:297. PMID: 23115550.
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    40. Wang JY, Hessl D, Iwahashi C, Cheung K, Schneider A, Hagerman RJ, Hagerman PJ, Rivera SM. Influence of the fragile X mental retardation (FMR1) gene on the brain and working memory in men with normal FMR1 alleles. Neuroimage. 2013 Jan 15; 65:288-98. PMID: 23063447.
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    41. Loomis EW, Eid JS, Peluso P, Yin J, Hickey L, Rank D, McCalmon S, Hagerman RJ, Tassone F, Hagerman PJ. Sequencing the unsequenceable: expanded CGG-repeat alleles of the fragile X gene. Genome Res. 2013 Jan; 23(1):121-8. PMID: 23064752.
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    42. Kaplan ES, Cao Z, Hulsizer S, Tassone F, Berman RF, Hagerman PJ, Pessah IN. Early mitochondrial abnormalities in hippocampal neurons cultured from Fmr1 pre-mutation mouse model. J Neurochem. 2012 Nov; 123(4):613-21. PMID: 22924671.
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    43. Yang JC, Chan SH, Khan S, Schneider A, Nanakul R, Teichholtz S, Niu YQ, Seritan A, Tassone F, Grigsby J, Hagerman PJ, Hagerman RJ, Olichney JM. Neural substrates of executive dysfunction in fragile X-associated tremor/ataxia syndrome (FXTAS): a brain potential study. Cereb Cortex. 2013 Nov; 23(11):2657-66. PMID: 22918986.
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    44. Winarni TI, Chonchaiya W, Sumekar TA, Ashwood P, Morales GM, Tassone F, Nguyen DV, Faradz SM, Van de Water J, Cook K, Hamlin A, Mu Y, Hagerman PJ, Hagerman RJ. Immune-mediated disorders among women carriers of fragile X premutation alleles. Am J Med Genet A. 2012 Oct; 158A(10):2473-81. PMID: 22903889.
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    45. Liu J, Koscielska KA, Cao Z, Hulsizer S, Grace N, Mitchell G, Nacey C, Githinji J, McGee J, Garcia-Arocena D, Hagerman RJ, Nolta J, Pessah IN, Hagerman PJ. Signaling defects in iPSC-derived fragile X premutation neurons. Hum Mol Genet. 2012 Sep 01; 21(17):3795-805. PMID: 22641815.
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    46. Hagerman PJ. Current Gaps in Understanding the Molecular Basis of FXTAS. Tremor Other Hyperkinet Mov (N Y). 2012; 2. PMID: 23440729.
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    47. Yrigollen CM, Durbin-Johnson B, Gane L, Nelson DL, Hagerman R, Hagerman PJ, Tassone F. AGG interruptions within the maternal FMR1 gene reduce the risk of offspring with fragile X syndrome. Genet Med. 2012 Aug; 14(8):729-36. PMID: 22498846.
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    48. Jenkins EC, Tassone F, Ye L, Hoogeveen AT, Brown WT, Hagerman RJ, Hagerman PJ. Reduced telomere length in individuals with FMR1 premutations and full mutations. Am J Med Genet A. 2012 May; 158A(5):1060-5. PMID: 22489017.
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    49. Tassone F, Greco CM, Hunsaker MR, Seritan AL, Berman RF, Gane LW, Jacquemont S, Basuta K, Jin LW, Hagerman PJ, Hagerman RJ. Neuropathological, clinical and molecular pathology in female fragile X premutation carriers with and without FXTAS. Genes Brain Behav. 2012 Jul; 11(5):577-85. PMID: 22463693.
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    50. Cao Z, Hulsizer S, Tassone F, Tang HT, Hagerman RJ, Rogawski MA, Hagerman PJ, Pessah IN. Clustered burst firing in FMR1 premutation hippocampal neurons: amelioration with allopregnanolone. Hum Mol Genet. 2012 Jul 01; 21(13):2923-35. PMID: 22466801.
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    51. Leehey MA, Hagerman PJ. Fragile X-associated tremor/ataxia syndrome. Handb Clin Neurol. 2012; 103:373-86. PMID: 21827901.
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    52. Selmeczy D, Koldewyn K, Wang JM, Lee A, Harvey D, Hessl DR, Tassone F, Adams P, Hagerman RJ, Hagerman PJ, Rivera SM. Investigation of amygdala volume in men with the fragile X premutation. Brain Imaging Behav. 2011 Dec; 5(4):285-94. PMID: 21786216.
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    53. Stöger R, Genereux DP, Hagerman RJ, Hagerman PJ, Tassone F, Laird CD. Testing the FMR1 promoter for mosaicism in DNA methylation among CpG sites, strands, and cells in FMR1-expressing males with fragile X syndrome. PLoS One. 2011; 6(8):e23648. PMID: 21909353.
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    54. Hunsaker MR, Greco CM, Spath MA, Smits AP, Navarro CS, Tassone F, Kros JM, Severijnen LA, Berry-Kravis EM, Berman RF, Hagerman PJ, Willemsen R, Hagerman RJ, Hukema RK. Widespread non-central nervous system organ pathology in fragile X premutation carriers with fragile X-associated tremor/ataxia syndrome and CGG knock-in mice. Acta Neuropathol. 2011 Oct; 122(4):467-79. PMID: 21785977.
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    55. Hessl D, Wang JM, Schneider A, Koldewyn K, Le L, Iwahashi C, Cheung K, Tassone F, Hagerman PJ, Rivera SM. Decreased fragile X mental retardation protein expression underlies amygdala dysfunction in carriers of the fragile X premutation. Biol Psychiatry. 2011 Nov 01; 70(9):859-65. PMID: 21783174.
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    56. Chen L, Hadd A, Sah S, Houghton JF, Filipovic-Sadic S, Zhang W, Hagerman PJ, Tassone F, Latham GJ. High-resolution methylation polymerase chain reaction for fragile X analysis: evidence for novel FMR1 methylation patterns undetected in Southern blot analyses. Genet Med. 2011 Jun; 13(6):528-538. PMID: 21430544.
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    57. Hunsaker MR, Greco CM, Tassone F, Berman RF, Willemsen R, Hagerman RJ, Hagerman PJ. Rare intranuclear inclusions in the brains of 3 older adult males with fragile x syndrome: implications for the spectrum of fragile x-associated disorders. J Neuropathol Exp Neurol. 2011 Jun; 70(6):462-9. PMID: 21572337.
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    58. Hagerman R, Au J, Hagerman P. FMR1 premutation and full mutation molecular mechanisms related to autism. J Neurodev Disord. 2011 Sep; 3(3):211-24. PMID: 21617890.
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    59. Hall DA, Berry-Kravis E, Zhang W, Tassone F, Spector E, Zerbe G, Hagerman PJ, Ouyang B, Leehey MA. FMR1 gray-zone alleles: association with Parkinson's disease in women? Mov Disord. 2011 Aug 15; 26(10):1900-6. PMID: 21567456.
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    60. Napoli E, Ross-Inta C, Wong S, Omanska-Klusek A, Barrow C, Iwahashi C, Garcia-Arocena D, Sakaguchi D, Berry-Kravis E, Hagerman R, Hagerman PJ, Giulivi C. Altered zinc transport disrupts mitochondrial protein processing/import in fragile X-associated tremor/ataxia syndrome. Hum Mol Genet. 2011 Aug 01; 20(15):3079-92. PMID: 21558427.
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    61. Narcisa V, Aguilar D, Nguyen DV, Campos L, Brodovsky J, White S, Adams P, Tassone F, Hagerman PJ, Hagerman RJ. A Quantitative Assessment of Tremor and Ataxia in Female FMR1 Premutation Carriers Using CATSYS. Curr Gerontol Geriatr Res. 2011; 2011:484713. PMID: 23008705.
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    62. Tassone F, De Rubeis S, Carosi C, La Fata G, Serpa G, Raske C, Willemsen R, Hagerman PJ, Bagni C. Differential usage of transcriptional start sites and polyadenylation sites in FMR1 premutation alleles. Nucleic Acids Res. 2011 Aug; 39(14):6172-85. PMID: 21478165.
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    63. Hoem G, Raske CR, Garcia-Arocena D, Tassone F, Sanchez E, Ludwig AL, Iwahashi CK, Kumar M, Yang JE, Hagerman PJ. CGG-repeat length threshold for FMR1 RNA pathogenesis in a cellular model for FXTAS. Hum Mol Genet. 2011 Jun 01; 20(11):2161-70. PMID: 21389081.
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    64. Greco CM, Navarro CS, Hunsaker MR, Maezawa I, Shuler JF, Tassone F, Delany M, Au JW, Berman RF, Jin LW, Schumann C, Hagerman PJ, Hagerman RJ. Neuropathologic features in the hippocampus and cerebellum of three older men with fragile X syndrome. Mol Autism. 2011 Feb 08; 2(1):2. PMID: 21303513.
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    65. Ludwig AL, Hershey JW, Hagerman PJ. Initiation of translation of the FMR1 mRNA Occurs predominantly through 5'-end-dependent ribosomal scanning. J Mol Biol. 2011 Mar 18; 407(1):21-34. PMID: 21237174.
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    66. Cunningham CL, Martínez Cerdeño V, Navarro Porras E, Prakash AN, Angelastro JM, Willemsen R, Hagerman PJ, Pessah IN, Berman RF, Noctor SC. Premutation CGG-repeat expansion of the Fmr1 gene impairs mouse neocortical development. Hum Mol Genet. 2011 Jan 01; 20(1):64-79. PMID: 20935171.
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    67. Hagerman R, Hoem G, Hagerman P. Fragile X and autism: Intertwined at the molecular level leading to targeted treatments. Mol Autism. 2010 Sep 21; 1(1):12. PMID: 20858229.
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    68. Ross-Inta C, Omanska-Klusek A, Wong S, Barrow C, Garcia-Arocena D, Iwahashi C, Berry-Kravis E, Hagerman RJ, Hagerman PJ, Giulivi C. Evidence of mitochondrial dysfunction in fragile X-associated tremor/ataxia syndrome. Biochem J. 2010 Aug 01; 429(3):545-52. PMID: 20513237.
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    69. Chen L, Hadd A, Sah S, Filipovic-Sadic S, Krosting J, Sekinger E, Pan R, Hagerman PJ, Stenzel TT, Tassone F, Latham GJ. An information-rich CGG repeat primed PCR that detects the full range of fragile X expanded alleles and minimizes the need for southern blot analysis. J Mol Diagn. 2010 Sep; 12(5):589-600. PMID: 20616364.
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    70. Paul R, Pessah IN, Gane L, Ono M, Hagerman PJ, Brunberg JA, Tassone F, Bourgeois JA, Adams PE, Nguyen DV, Hagerman R. Early onset of neurological symptoms in fragile X premutation carriers exposed to neurotoxins. Neurotoxicology. 2010 Aug; 31(4):399-402. PMID: 20466021.
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    71. Garcia-Arocena D, Hagerman PJ. Advances in understanding the molecular basis of FXTAS. Hum Mol Genet. 2010 Apr 15; 19(R1):R83-9. PMID: 20430935.
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    72. Adams PE, Adams JS, Nguyen DV, Hessl D, Brunberg JA, Tassone F, Zhang W, Koldewyn K, Rivera SM, Grigsby J, Zhang L, Decarli C, Hagerman PJ, Hagerman RJ. Psychological symptoms correlate with reduced hippocampal volume in fragile X premutation carriers. Am J Med Genet B Neuropsychiatr Genet. 2010 Apr 05; 153B(3):775-85. PMID: 19908235.
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    73. Sellier C, Rau F, Liu Y, Tassone F, Hukema RK, Gattoni R, Schneider A, Richard S, Willemsen R, Elliott DJ, Hagerman PJ, Charlet-Berguerand N. Sam68 sequestration and partial loss of function are associated with splicing alterations in FXTAS patients. EMBO J. 2010 Apr 07; 29(7):1248-61. PMID: 20186122.
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    74. Filipovic-Sadic S, Sah S, Chen L, Krosting J, Sekinger E, Zhang W, Hagerman PJ, Stenzel TT, Hadd AG, Latham GJ, Tassone F. A novel FMR1 PCR method for the routine detection of low abundance expanded alleles and full mutations in fragile X syndrome. Clin Chem. 2010 Mar; 56(3):399-408. PMID: 20056738.
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    75. Chen Y, Tassone F, Berman RF, Hagerman PJ, Hagerman RJ, Willemsen R, Pessah IN. Murine hippocampal neurons expressing Fmr1 gene premutations show early developmental deficits and late degeneration. Hum Mol Genet. 2010 Jan 01; 19(1):196-208. PMID: 19846466.
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    76. Raske C, Hagerman PJ. Molecular pathogenesis of fragile X-associated tremor/ataxia syndrome. J Investig Med. 2009 Dec; 57(8):825-9. PMID: 19794313.
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    77. Garcia-Arocena D, Yang JE, Brouwer JR, Tassone F, Iwahashi C, Berry-Kravis EM, Goetz CG, Sumis AM, Zhou L, Nguyen DV, Campos L, Howell E, Ludwig A, Greco C, Willemsen R, Hagerman RJ, Hagerman PJ. Fibroblast phenotype in male carriers of FMR1 premutation alleles. Hum Mol Genet. 2010 Jan 15; 19(2):299-312. PMID: 19864489.
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    165. Hagerman PJ, Greco CM, Hagerman RJ. A cerebellar tremor/ataxia syndrome among fragile X premutation carriers. Cytogenet Genome Res. 2003; 100(1-4):206-12. PMID: 14526182.
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    166. Tassone F, Hagerman PJ. Expression of the FMR1 gene. Cytogenet Genome Res. 2003; 100(1-4):124-8. PMID: 14526172.
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    167. Primerano B, Tassone F, Hagerman RJ, Hagerman P, Amaldi F, Bagni C. Reduced FMR1 mRNA translation efficiency in fragile X patients with premutations. RNA. 2002 Dec; 8(12):1482-8. PMID: 12515381.
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    168. Brunberg JA, Jacquemont S, Hagerman RJ, Berry-Kravis EM, Grigsby J, Leehey MA, Tassone F, Brown WT, Greco CM, Hagerman PJ. Fragile X premutation carriers: characteristic MR imaging findings of adult male patients with progressive cerebellar and cognitive dysfunction. AJNR Am J Neuroradiol. 2002 Nov-Dec; 23(10):1757-66. PMID: 12427636.
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    169. Greco CM, Hagerman RJ, Tassone F, Chudley AE, Del Bigio MR, Jacquemont S, Leehey M, Hagerman PJ. Neuronal intranuclear inclusions in a new cerebellar tremor/ataxia syndrome among fragile X carriers. Brain. 2002 Aug; 125(Pt 8):1760-71. PMID: 12135967.
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    170. van Oppen MJ, Catmull J, McDonald BJ, Hislop NR, Hagerman PJ, Miller DJ. The mitochondrial genome of Acropora tenuis (Cnidaria; Scleractinia) contains a large group I intron and a candidate control region. J Mol Evol. 2002 Jul; 55(1):1-13. PMID: 12165838.
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    171. Hagerman RJ, Hagerman PJ. The fragile X premutation: into the phenotypic fold. Curr Opin Genet Dev. 2002 Jun; 12(3):278-83. PMID: 12076670.
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    172. Hagerman RJ, Hagerman PJ. Fragile X syndrome: a model of gene-brain-behavior relationships. Mol Genet Metab. 2001 Sep-Oct; 74(1-2):89-97. PMID: 11592806.
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    173. Chiang PW, Carpenter LE, Hagerman PJ. The 5'-untranslated region of the FMR1 message facilitates translation by internal ribosome entry. J Biol Chem. 2001 Oct 12; 276(41):37916-21. PMID: 11489899.
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    174. Hagerman RJ, Leehey M, Heinrichs W, Tassone F, Wilson R, Hills J, Grigsby J, Gage B, Hagerman PJ. Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X. Neurology. 2001 Jul 10; 57(1):127-30. PMID: 11445641.
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    175. Tassone F, Hagerman RJ, Taylor AK, Hagerman PJ. A majority of fragile X males with methylated, full mutation alleles have significant levels of FMR1 messenger RNA. J Med Genet. 2001 Jul; 38(7):453-6. PMID: 11432964.
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    176. Stagg SM, Frazer-Abel AA, Hagerman PJ, Harvey SC. Structural studies of the tRNA domain of tmRNA. J Mol Biol. 2001 Jun 08; 309(3):727-35. PMID: 11397092.
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    177. Tassone F, Hagerman RJ, Loesch DZ, Lachiewicz A, Taylor AK, Hagerman PJ. Fragile X males with unmethylated, full mutation trinucleotide repeat expansions have elevated levels of FMR1 messenger RNA. Am J Med Genet. 2000 Sep 18; 94(3):232-6. PMID: 10995510.
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    178. Tassone F, Hagerman RJ, Taylor AK, Mills JB, Harris SW, Gane LW, Hagerman PJ. Clinical involvement and protein expression in individuals with the FMR1 premutation. Am J Med Genet. 2000 Mar 13; 91(2):144-52. PMID: 10748416.
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    179. Tassone F, Hagerman RJ, Chamberlain WD, Hagerman PJ. Transcription of the FMR1 gene in individuals with fragile X syndrome. Am J Med Genet. 2000; 97(3):195-203. PMID: 11449488.
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    180. Hagerman PJ. Transient electric birefringence for determining global conformations of nonhelix elements and protein-induced bends in RNA. Methods Enzymol. 2000; 317:440-53. PMID: 10829294.
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    181. Tassone F, Hagerman RJ, Taylor AK, Gane LW, Godfrey TE, Hagerman PJ. Elevated levels of FMR1 mRNA in carrier males: a new mechanism of involvement in the fragile-X syndrome. Am J Hum Genet. 2000 Jan; 66(1):6-15. PMID: 10631132.
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    182. van Oppen MJ, Hislop NR, Hagerman PJ, Miller DJ. Gene content and organization in a segment of the mitochondrial genome of the scleractinian coral Acropora tenuis: major differences in gene order within the anthozoan subclass zoantharia. Mol Biol Evol. 1999 Dec; 16(12):1812-5. PMID: 10605123.
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    183. Frazer-Abel AA, Hagerman PJ. Determination of the angle between the acceptor and anticodon stems of a truncated mitochondrial tRNA. J Mol Biol. 1999 Jan 15; 285(2):581-93. PMID: 9878431.
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    184. Mills JB, Vacano E, Hagerman PJ. Flexibility of single-stranded DNA: use of gapped duplex helices to determine the persistence lengths of poly(dT) and poly(dA). J Mol Biol. 1999 Jan 08; 285(1):245-57. PMID: 9878403.
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    185. Friederich MW, Vacano E, Hagerman PJ. Global flexibility of tertiary structure in RNA: yeast tRNAPhe as a model system. Proc Natl Acad Sci U S A. 1998 Mar 31; 95(7):3572-7. PMID: 9520407.
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    186. Orr JW, Hagerman PJ, Williamson JR. Protein and Mg(2+)-induced conformational changes in the S15 binding site of 16 S ribosomal RNA. J Mol Biol. 1998 Jan 23; 275(3):453-64. PMID: 9466923.
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    187. Zacharias M, Hagerman PJ. Influence of static and dynamic bends on the birefringence decay profile of RNA helices: Brownian dynamics simulations. Biophys J. 1997 Jul; 73(1):318-32. PMID: 9199796.
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    188. Vacano E, Hagerman PJ. Analysis of birefringence decay profiles for nucleic acid helices possessing bends: the tau-ratio approach. Biophys J. 1997 Jul; 73(1):306-17. PMID: 9199795.
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    189. Friederich MW, Hagerman PJ. The angle between the anticodon and aminoacyl acceptor stems of yeast tRNA(Phe) is strongly modulated by magnesium ions. Biochemistry. 1997 May 20; 36(20):6090-9. PMID: 9166779.
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    190. Hagerman PJ. Flexibility of RNA. Annu Rev Biophys Biomol Struct. 1997; 26:139-56. PMID: 9241416.
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    191. Hagerman PJ. Sometimes a great motion: the application of transient electric birefringence to the study of macromolecular structure. Curr Opin Struct Biol. 1996 Oct; 6(5):643-9. PMID: 8913687.
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    192. Hagerman PJ. Do basic region-leucine zipper proteins bend their DNA targets ... does it matter? Proc Natl Acad Sci U S A. 1996 Sep 17; 93(19):9993-6. PMID: 8816735.
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    193. Amiri KM, Hagerman PJ. The global conformation of an active hammerhead RNA during the process of self-cleavage. J Mol Biol. 1996 Aug 16; 261(2):125-34. PMID: 8757281.
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    194. Hagerman KR, Hagerman PJ. Helix rigidity of DNA: the meroduplex as an experimental paradigm. J Mol Biol. 1996 Jul 12; 260(2):207-23. PMID: 8764401.
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    195. Hagerman PJ, Amiri KM. Hammering away at RNA global structure. Curr Opin Struct Biol. 1996 Jun; 6(3):317-21. PMID: 8804834.
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    196. Hagerman PJ, Tinoco I. From sequence to structure to function. Curr Opin Struct Biol. 1996 06 01; 6(3):277-80. PMID: 8805487.
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    197. Zacharias M, Hagerman PJ. The influence of symmetric internal loops on the flexibility of RNA. J Mol Biol. 1996 Mar 29; 257(2):276-89. PMID: 8609623.
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    198. Leehey MA, Squassoni CA, Friederich MW, Mills JB, Hagerman PJ. A noncanonical tertiary conformation of a human mitochondrial transfer RNA. Biochemistry. 1995 Dec 19; 34(50):16235-9. PMID: 8845346.
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    199. Lilley DM, Clegg RM, Diekmann S, Seeman NC, Von Kitzing E, Hagerman PJ. A nomenclature of junctions and branchpoints in nucleic acids. Nucleic Acids Res. 1995 Sep 11; 23(17):3363-4. PMID: 16617514.
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    200. Zacharias M, Hagerman PJ. The bend in RNA created by the trans-activation response element bulge of human immunodeficiency virus is straightened by arginine and by Tat-derived peptide. Proc Natl Acad Sci U S A. 1995 Jun 20; 92(13):6052-6. PMID: 7597079.
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    201. Friederich MW, Gast FU, Vacano E, Hagerman PJ. Determination of the angle between the anticodon and aminoacyl acceptor stems of yeast phenylalanyl tRNA in solution. Proc Natl Acad Sci U S A. 1995 May 23; 92(11):4803-7. PMID: 7761403.
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    202. Lilley DM, Clegg RM, Diekmann S, Seeman NC, von Kitzing E, Hagerman P. Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB). A nomenclature of junctions and branchpoints in nucleic acids. Recommendations 1994. Eur J Biochem. 1995 May 15; 230(1):1-2. PMID: 7601087.
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    203. Kebbekus P, Draper DE, Hagerman P. Persistence length of RNA. Biochemistry. 1995 Apr 04; 34(13):4354-7. PMID: 7535562.
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    204. Zacharias M, Hagerman PJ. Bulge-induced bends in RNA: quantification by transient electric birefringence. J Mol Biol. 1995 Mar 31; 247(3):486-500. PMID: 7536250.
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    205. Hodges-Garcia Y, Hagerman PJ. Investigation of the influence of cytosine methylation on DNA flexibility. J Biol Chem. 1995 Jan 06; 270(1):197-201. PMID: 7814373.
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    206. Amiri KM, Hagerman PJ. Global conformation of a self-cleaving hammerhead RNA. Biochemistry. 1994 Nov 15; 33(45):13172-7. PMID: 7947724.
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    207. Olmsted MC, Hagerman PJ. Excess counterion accumulation around branched nucleic acids. J Mol Biol. 1994 Nov 11; 243(5):919-29. PMID: 7525974.
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    208. Shen Z, Hagerman PJ. Conformation of the central, three-helix junction of the 5 S ribosomal RNA of Sulfolobus acidocaldarius. J Mol Biol. 1994 Aug 19; 241(3):415-30. PMID: 7520504.
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    209. Gast FU, Amiri KM, Hagerman PJ. Interhelix geometry of stems I and II of a self-cleaving hammerhead RNA. Biochemistry. 1994 Feb 22; 33(7):1788-96. PMID: 7509191.
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    210. Mills JB, Cooper JP, Hagerman PJ. Electrophoretic evidence that single-stranded regions of one or more nucleotides dramatically increase the flexibility of DNA. Biochemistry. 1994 Feb 22; 33(7):1797-803. PMID: 8110781.
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    211. Hodges-Garcia Y, Hagerman PJ. Cytosine methylation can induce local distortions in the structure of duplex DNA. Biochemistry. 1992 Aug 25; 31(33):7595-9. PMID: 1510946.
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    212. Hagerman PJ. Straightening out the bends in curved DNA. Biochim Biophys Acta. 1992 Jun 15; 1131(2):125-32. PMID: 1610891.
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    213. Gast FU, Hagerman PJ. Electrophoretic and hydrodynamic properties of duplex ribonucleic acid molecules transcribed in vitro: evidence that A-tracts do not generate curvature in RNA. Biochemistry. 1991 Apr 30; 30(17):4268-77. PMID: 2021619.
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    214. Hagerman PJ. RNA 'tetraloops': living in syn. Curr Biol. 1991 Feb; 1(1):50-2. PMID: 15336208.
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    215. Hagerman PJ. DNA typing in the forensic arena. Am J Hum Genet. 1990 Nov; 47(5):876-7. PMID: 2278587.
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    216. Cooper JP, Hagerman PJ. Analysis of fluorescence energy transfer in duplex and branched DNA molecules. Biochemistry. 1990 Oct 02; 29(39):9261-8. PMID: 2271593.
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    217. Hagerman PJ, Ramadevi VA. Application of the method of phage T4 DNA ligase-catalyzed ring-closure to the study of DNA structure. I. Computational analysis. J Mol Biol. 1990 Mar 20; 212(2):351-62. PMID: 2319603.
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    218. Taylor WH, Hagerman PJ. Application of the method of phage T4 DNA ligase-catalyzed ring-closure to the study of DNA structure. II. NaCl-dependence of DNA flexibility and helical repeat. J Mol Biol. 1990 Mar 20; 212(2):363-76. PMID: 2319604.
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    219. Hagerman PJ. Pyrimidine 5-methyl groups influence the magnitude of DNA curvature. Biochemistry. 1990 Feb 27; 29(8):1980-3. PMID: 2328230.
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    220. Hagerman PJ. Sequence-directed curvature of DNA. Annu Rev Biochem. 1990; 59:755-81. PMID: 2197990.
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    221. Cooper JP, Hagerman PJ. Geometry of a branched DNA structure in solution. Proc Natl Acad Sci U S A. 1989 Oct; 86(19):7336-40. PMID: 2798413.
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    222. Hodges-Garcia Y, Hagerman PJ, Pettijohn DE. DNA ring closure mediated by protein HU. J Biol Chem. 1989 Sep 05; 264(25):14621-3. PMID: 2768236.
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    223. Hagerman PJ. Flexibility of DNA. Annu Rev Biophys Biophys Chem. 1988; 17:265-86. PMID: 3293588.
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    224. Cooper JP, Hagerman PJ. Gel electrophoretic analysis of the geometry of a DNA four-way junction. J Mol Biol. 1987 Dec 20; 198(4):711-9. PMID: 2828644.
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    225. Taylor WH, Hagerman PJ. A general method for cloning DNA fragments in multiple copies. Gene. 1987; 53(2-3):139-44. PMID: 3609745.
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    226. Hagerman PJ. Sequence-directed curvature of DNA. Nature. 1986 May 22-28; 321(6068):449-50. PMID: 3713816.
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    227. Hagerman PJ. Sequence dependence of the curvature of DNA: a test of the phasing hypothesis. Biochemistry. 1985 Dec 03; 24(25):7033-7. PMID: 4084556.
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    228. Hagerman PJ. Analysis of the ring-closure probabilities of isotropic wormlike chains: application to duplex DNA. Biopolymers. 1985 Oct; 24(10):1881-97. PMID: 4074845.
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    229. Hagerman PJ. Application of transient electric birefringence to the study of biopolymer structure. Methods Enzymol. 1985; 117:198-219. PMID: 3001479.
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    230. Sinden RR, Hagerman PJ. Interstrand psoralen cross-links do not introduce appreciable bends in DNA. Biochemistry. 1984 Dec 18; 23(26):6299-303. PMID: 6529552.
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    231. Hagerman PJ. The relationship between uracil incorporation into DNA and the expression of fragile sites in human. Am J Med Genet. 1984 Oct; 19(2):407-9. PMID: 6507488.
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    232. Hagerman PJ. Evidence for the existence of stable curvature of DNA in solution. Proc Natl Acad Sci U S A. 1984 Aug; 81(15):4632-6. PMID: 6087336.
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    233. Hagerman RJ, McBogg P, Hagerman PJ. The fragile X syndrome: history, diagnosis, and treatment. J Dev Behav Pediatr. 1983 Jun; 4(2):122-30. PMID: 6348096.
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    234. Hagerman PJ. Electrostatic contribution to the stiffness of DNA molecules of finite length. Biopolymers. 1983 Mar; 22(3):811-4. PMID: 6850051.
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    235. Hagerman PJ. Investigation of the flexibility of DNA using transient electric birefringence. Biopolymers. 1981 Jul; 20(7):1503-35. PMID: 7023566.
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    236. Hagerman PJ, Schmid FX, Baldwin RL. Refolding behavior of a kinetic intermediate observed in the low pH unfolding of ribonuclease A. Biochemistry. 1979 Jan 23; 18(2):293-7. PMID: 33695.
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    237. Hagerman PJ. Kinetic analysis of the reversible folding reactions of small proteins: application to the folding of lysozyme and cytochrome c. Biopolymers. 1977 Apr; 16(4):731-47. PMID: 192357.
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    238. Hagerman PJ, Baldwin RL. A quantitative treatment of the kinetics of the folding transition of ribonuclease A. Biochemistry. 1976 Apr 06; 15(7):1462-73. PMID: 4087.
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