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Paul J Hagerman

TitleProfessor
InstitutionUniversity of California Davis
DepartmentBiochemistry and Molecular Medicine
Address4455A Tupper Hall
CA 95616
Phone530-754-7266
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Epigenetic regulation of the FMR1 gene
    NIH/NIGMS R01GM113929Sep 21, 2015 - May 31, 2019
    Role: Principal Investigator
    Human iPSC neuronal models for early and late phases of FXTAS neurodegeneration
    NIH/NIA RC1AG036022Sep 30, 2009 - Aug 31, 2011
    Role: Principal Investigator
    Development of targeted therapeutic agents for the treatment of FXTAS (2 of 6)
    NIH/NIA RL1AG032119Sep 30, 2007 - Jun 30, 2012
    Role: Principal Investigator
    Neuro Therapeutics Research Institute (1 of 6)
    NIH/NIDCR UL1DE019583Sep 15, 2007 - Jun 30, 2012
    Role: Principal Investigator
    Neuro Therapeutics Research Institute
    NIH/NCRR UL1RR024922Sep 15, 2007 - Jun 30, 2012
    Role: Principal Investigator
    Fragile X-associated Tremor/Ataxia Syndrome
    NIH/NIA R01AG024488Jun 15, 2005 - May 31, 2011
    Role: Principal Investigator
    Neurological Phenotype in FMR1 Premutation Carriers
    NIH/NINDS R01NS043532Jul 1, 2002 - Jun 30, 2006
    Role: Principal Investigator
    Expression of the fragile X gene
    NIH/NICHD R01HD040661Apr 1, 2002 - Dec 31, 2016
    Role: Principal Investigator
    TRNA STRUCTURE IN SOLUTION
    NIH/NIGMS R01GM052557Aug 1, 1996 - Jul 31, 2001
    Role: Principal Investigator
    PROTEIN NUCLEIC ACID INTERACTIONS
    NIH/NIGMS R01GM035305Jul 1, 1985 - Jun 30, 2004
    Role: Principal Investigator
    FLEXIBILITY OF DNA
    NIH/NIGMS R01GM028293Jul 1, 1980 - Jun 30, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Jiraanont P, Kumar M, Tang HT, Espinal G, Hagerman PJ, Hagerman RJ, Chutabhakdikul N, Tassone F. Size and methylation mosaicism in males with Fragile X syndrome. Expert Rev Mol Diagn. 2017 Nov; 17(11):1023-1032. PMID: 28929824.
      View in: PubMed
    2. Hagerman RJ, Berry-Kravis E, Hazlett HC, Bailey DB, Moine H, Kooy RF, Tassone F, Gantois I, Sonenberg N, Mandel JL, Hagerman PJ. Fragile X syndrome. Nat Rev Dis Primers. 2017 Sep 29; 3:17065. PMID: 28960184.
      View in: PubMed
    3. Lechpammer M, Martínez Cerdeno V, Hunsaker MR, Hah M, Gonzales H, Tisch S, Joffe R, Pamphlett R, Tassone F, Hagerman PJ, Bolitho SJ, Hagerman RJ. Concomitant occurrence of FXTAS and clinically defined sporadic inclusion body myositis: report of two cases. Croat Med J. 2017 Aug 31; 58(4):310-315. PMID: 28857524.
      View in: PubMed
    4. Robin G, López JR, Espinal GM, Hulsizer S, Hagerman PJ, Pessah IN. Calcium dysregulation and Cdk5-ATM pathway involved in a mouse model of fragile X-associated tremor/ataxia syndrome. Hum Mol Genet. 2017 07 15; 26(14):2649-2666. PMID: 28444183.
      View in: PubMed
    5. Martínez-Cerdeño V, Lechpammer M, Hagerman PJ, Hagerman R. Two FMR1 premutation cases without nuclear inclusions. Mov Disord. 2017 Sep; 32(9):1328-1329. PMID: 28568317.
      View in: PubMed
    6. Jiraanont P, Sweha SR, AlOlaby RR, Silva M, Tang HT, Durbin-Johnson B, Schneider A, Espinal GM, Hagerman PJ, Rivera SM, Hessl D, Hagerman RJ, Chutabhakdikul N, Tassone F. Clinical and molecular correlates in fragile X premutation females. eNeurologicalSci. 2017 Jun; 7:49-56. PMID: 28971146.
      View in: PubMed
    7. Martínez-Cerdeño V, Lechpammer M, Noctor S, Ariza J, Hagerman P, Hagerman R. FMR1 premutation with Prader-Willi phenotype and fragile X-associated tremor/ataxia syndrome. Clin Case Rep. 2017 May; 5(5):625-629. PMID: 28469864.
      View in: PubMed
    8. Ariza J, Rogers H, Hartvigsen A, Snell M, Dill M, Judd D, Hagerman P, Martínez-Cerdeño V. Iron accumulation and dysregulation in the putamen in fragile X-associated tremor/ataxia syndrome. Mov Disord. 2017 04; 32(4):585-591. PMID: 28233916.
      View in: PubMed
    9. Rogers H, Ariza J, Monterrubio A, Hagerman P, Martínez-Cerdeño V. Cerebellar Mild Iron Accumulation in a Subset of FMR1 Premutation Carriers with FXTAS. Cerebellum. 2016 10; 15(5):641-4. PMID: 27259564.
      View in: PubMed
    10. Ariza J, Rogers H, Monterrubio A, Reyes-Miranda A, Hagerman PJ, Martínez-Cerdeño V. A Majority of FXTAS Cases Present with Intranuclear Inclusions Within Purkinje Cells. Cerebellum. 2016 10; 15(5):546-51. PMID: 27108270.
      View in: PubMed
    11. Hagerman RJ, Hagerman P. Fragile X-associated tremor/ataxia syndrome - features, mechanisms and management. Nat Rev Neurol. 2016 Jul; 12(7):403-12. PMID: 27340021.
      View in: PubMed
    12. Kashima R, Roy S, Ascano M, Martinez-Cerdeno V, Ariza-Torres J, Kim S, Louie J, Lu Y, Leyton P, Bloch KD, Kornberg TB, Hagerman PJ, Hagerman R, Lagna G, Hata A. Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome. Sci Signal. 2016 06 07; 9(431):ra58. PMID: 27273096.
      View in: PubMed
    13. Pham TT, Yin J, Eid JS, Adams E, Lam R, Turner SW, Loomis EW, Wang JY, Hagerman PJ, Hanes JW. Single-locus enrichment without amplification for sequencing and direct detection of epigenetic modifications. Mol Genet Genomics. 2016 Jun; 291(3):1491-504. PMID: 26825750.
      View in: PubMed
    14. Hukema RK, Buijsen RA, Schonewille M, Raske C, Severijnen LA, Nieuwenhuizen-Bakker I, Verhagen RF, van Dessel L, Maas A, Charlet-Berguerand N, De Zeeuw CI, Hagerman PJ, Berman RF, Willemsen R. Reversibility of neuropathology and motor deficits in an inducible mouse model for FXTAS. Hum Mol Genet. 2015 Sep 01; 24(17):4948-57. PMID: 26060190; PMCID: PMC4527492.
    15. Hagerman PJ, Hagerman RJ. Fragile X-associated tremor/ataxia syndrome. Ann N Y Acad Sci. 2015 Mar; 1338:58-70. PMID: 25622649; PMCID: PMC4363162.
    16. Ariza J, Steward C, Rueckert F, Widdison M, Coffman R, Afjei A, Noctor SC, Hagerman R, Hagerman P, Martínez-Cerdeño V. Dysregulated iron metabolism in the choroid plexus in fragile X-associated tremor/ataxia syndrome. Brain Res. 2015 Feb 19; 1598:88-96. PMID: 25498860; PMCID: PMC4340768.
    17. Pretto DI, Eid JS, Yrigollen CM, Tang HT, Loomis EW, Raske C, Durbin-Johnson B, Hagerman PJ, Tassone F. Differential increases of specific FMR1 mRNA isoforms in premutation carriers. J Med Genet. 2015 Jan; 52(1):42-52. PMID: 25358671; PMCID: PMC4394606.
    18. Pretto D, Yrigollen CM, Tang HT, Williamson J, Espinal G, Iwahashi CK, Durbin-Johnson B, Hagerman RJ, Hagerman PJ, Tassone F. Clinical and molecular implications of mosaicism in FMR1 full mutations. Front Genet. 2014; 5:318. PMID: 25278957; PMCID: PMC4166380.
    19. Yang JC, Chi L, Teichholtz S, Schneider A, Nanakul R, Nowacki R, Seritan A, Reed B, DeCarli C, Iragui VJ, Kutas M, Hagerman PJ, Hagerman RJ, Olichney JM. ERP abnormalities elicited by word repetition in fragile X-associated tremor/ataxia syndrome (FXTAS) and amnestic MCI. Neuropsychologia. 2014 Oct; 63:34-42. PMID: 25111034; PMCID: PMC4194142.
    20. Tassone F, Hagerman PJ, Hagerman RJ. Fragile x premutation. J Neurodev Disord. 2014; 6(1):22. PMID: 25170346; PMCID: PMC4147873.
    21. Sahdeo S, Tomilov A, Komachi K, Iwahashi C, Datta S, Hughes O, Hagerman P, Cortopassi G. High-throughput screening of FDA-approved drugs using oxygen biosensor plates reveals secondary mitofunctional effects. Mitochondrion. 2014 Jul; 17:116-25. PMID: 25034306; PMCID: PMC4142054.
    22. Yang JC, Niu YQ, Simon C, Seritan AL, Chen L, Schneider A, Moghaddam ST, Hagerman PJ, Hagerman RJ, Olichney JM. Memantine effects on verbal memory in fragile X-associated tremor/ataxia syndrome (FXTAS): a double-blind brain potential study. Neuropsychopharmacology. 2014 Nov; 39(12):2760-8. PMID: 24871547; PMCID: PMC4200486.
    23. Juang BT, Ludwig AL, Benedetti KL, Gu C, Collins K, Morales C, Asundi A, Wittmann T, L'Etoile N, Hagerman PJ. Expression of an expanded CGG-repeat RNA in a single pair of primary sensory neurons impairs olfactory adaptation in Caenorhabditis elegans. Hum Mol Genet. 2014 Sep 15; 23(18):4945-59. PMID: 24821701; PMCID: PMC4140470.
    24. Loomis EW, Sanz LA, Chédin F, Hagerman PJ. Transcription-associated R-loop formation across the human FMR1 CGG-repeat region. PLoS Genet. 2014 Apr; 10(4):e1004294. PMID: 24743386; PMCID: PMC3990486.
    25. Seritan AL, Nguyen DV, Mu Y, Tassone F, Bourgeois JA, Schneider A, Cogswell JB, Cook KR, Leehey MA, Grigsby J, Olichney JM, Adams PE, Legg W, Zhang L, Hagerman PJ, Hagerman RJ. Memantine for fragile X-associated tremor/ataxia syndrome: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2014 Mar; 75(3):264-71. PMID: 24345444; PMCID: PMC4296896.
    26. Ludwig AL, Espinal GM, Pretto DI, Jamal AL, Arque G, Tassone F, Berman RF, Hagerman PJ. CNS expression of murine fragile X protein (FMRP) as a function of CGG-repeat size. Hum Mol Genet. 2014 Jun 15; 23(12):3228-38. PMID: 24463622; PMCID: PMC4030777.
    27. Hukema RK, Buijsen RA, Raske C, Severijnen LA, Nieuwenhuizen-Bakker I, Minneboo M, Maas A, de Crom R, Kros JM, Hagerman PJ, Berman RF, Willemsen R. Induced expression of expanded CGG RNA causes mitochondrial dysfunction in vivo. Cell Cycle. 2014; 13(16):2600-8. PMID: 25486200; PMCID: PMC4614669.
    28. Hagerman R, Hagerman P. Advances in clinical and molecular understanding of the FMR1 premutation and fragile X-associated tremor/ataxia syndrome. Lancet Neurol. 2013 Aug; 12(8):786-98. PMID: 23867198; PMCID: PMC3922535.
    29. Yang JC, Simon C, Niu YQ, Bogost M, Schneider A, Tassone F, Seritan A, Grigsby J, Hagerman PJ, Hagerman RJ, Olichney JM. Phenotypes of hypofrontality in older female fragile X premutation carriers. Ann Neurol. 2013 Aug; 74(2):275-83. PMID: 23686745; PMCID: PMC3906211.
    30. Hagerman P. Fragile X-associated tremor/ataxia syndrome (FXTAS): pathology and mechanisms. Acta Neuropathol. 2013 Jul; 126(1):1-19. PMID: 23793382; PMCID: PMC3904666.
    31. Pretto DI, Hunsaker MR, Cunningham CL, Greco CM, Hagerman RJ, Noctor SC, Hall DA, Hagerman PJ, Tassone F. Intranuclear inclusions in a fragile X mosaic male. Transl Neurodegener. 2013 May 21; 2(1):10. PMID: 23692864; PMCID: PMC3668897.
    32. Cao Z, Hulsizer S, Cui Y, Pretto DL, Kim KH, Hagerman PJ, Tassone F, Pessah IN. Enhanced asynchronous Ca(2+) oscillations associated with impaired glutamate transport in cortical astrocytes expressing Fmr1 gene premutation expansion. J Biol Chem. 2013 May 10; 288(19):13831-41. PMID: 23553633; PMCID: PMC3650419.
    33. Sellier C, Freyermuth F, Tabet R, Tran T, He F, Ruffenach F, Alunni V, Moine H, Thibault C, Page A, Tassone F, Willemsen R, Disney MD, Hagerman PJ, Todd PK, Charlet-Berguerand N. Sequestration of DROSHA and DGCR8 by expanded CGG RNA repeats alters microRNA processing in fragile X-associated tremor/ataxia syndrome. Cell Rep. 2013 Mar 28; 3(3):869-80. PMID: 23478018; PMCID: PMC3639429.
    34. Wang JM, Koldewyn K, Hashimoto R, Schneider A, Le L, Tassone F, Cheung K, Hagerman P, Hessl D, Rivera SM. Male carriers of the FMR1 premutation show altered hippocampal-prefrontal function during memory encoding. Front Hum Neurosci. 2012; 6:297. PMID: 23115550; PMCID: PMC3483622.
    35. Wang JY, Hessl D, Iwahashi C, Cheung K, Schneider A, Hagerman RJ, Hagerman PJ, Rivera SM. Influence of the fragile X mental retardation (FMR1) gene on the brain and working memory in men with normal FMR1 alleles. Neuroimage. 2013 Jan 15; 65:288-98. PMID: 23063447; PMCID: PMC3540208.
    36. Loomis EW, Eid JS, Peluso P, Yin J, Hickey L, Rank D, McCalmon S, Hagerman RJ, Tassone F, Hagerman PJ. Sequencing the unsequenceable: expanded CGG-repeat alleles of the fragile X gene. Genome Res. 2013 Jan; 23(1):121-8. PMID: 23064752; PMCID: PMC3530672.
    37. Kaplan ES, Cao Z, Hulsizer S, Tassone F, Berman RF, Hagerman PJ, Pessah IN. Early mitochondrial abnormalities in hippocampal neurons cultured from Fmr1 pre-mutation mouse model. J Neurochem. 2012 Nov; 123(4):613-21. PMID: 22924671; PMCID: PMC3564636.
    38. Yang JC, Chan SH, Khan S, Schneider A, Nanakul R, Teichholtz S, Niu YQ, Seritan A, Tassone F, Grigsby J, Hagerman PJ, Hagerman RJ, Olichney JM. Neural substrates of executive dysfunction in fragile X-associated tremor/ataxia syndrome (FXTAS): a brain potential study. Cereb Cortex. 2013 Nov; 23(11):2657-66. PMID: 22918986; PMCID: PMC3792740.
    39. Winarni TI, Chonchaiya W, Sumekar TA, Ashwood P, Morales GM, Tassone F, Nguyen DV, Faradz SM, Van de Water J, Cook K, Hamlin A, Mu Y, Hagerman PJ, Hagerman RJ. Immune-mediated disorders among women carriers of fragile X premutation alleles. Am J Med Genet A. 2012 Oct; 158A(10):2473-81. PMID: 22903889; PMCID: PMC4105154.
    40. Liu J, Koscielska KA, Cao Z, Hulsizer S, Grace N, Mitchell G, Nacey C, Githinji J, McGee J, Garcia-Arocena D, Hagerman RJ, Nolta J, Pessah IN, Hagerman PJ. Signaling defects in iPSC-derived fragile X premutation neurons. Hum Mol Genet. 2012 Sep 01; 21(17):3795-805. PMID: 22641815; PMCID: PMC3412379.
    41. Hagerman PJ. Current Gaps in Understanding the Molecular Basis of FXTAS. Tremor Other Hyperkinet Mov (N Y). 2012; 2. PMID: 23440729; PMCID: PMC3379894.
    42. Yrigollen CM, Durbin-Johnson B, Gane L, Nelson DL, Hagerman R, Hagerman PJ, Tassone F. AGG interruptions within the maternal FMR1 gene reduce the risk of offspring with fragile X syndrome. Genet Med. 2012 Aug; 14(8):729-36. PMID: 22498846; PMCID: PMC3990283.
    43. Cao Z, Hulsizer S, Tassone F, Tang HT, Hagerman RJ, Rogawski MA, Hagerman PJ, Pessah IN. Clustered burst firing in FMR1 premutation hippocampal neurons: amelioration with allopregnanolone. Hum Mol Genet. 2012 Jul 01; 21(13):2923-35. PMID: 22466801; PMCID: PMC3373240.
    44. Leehey MA, Hagerman PJ. Fragile X-associated tremor/ataxia syndrome. Handb Clin Neurol. 2012; 103:373-86. PMID: 21827901.
      View in: PubMed
    45. Selmeczy D, Koldewyn K, Wang JM, Lee A, Harvey D, Hessl DR, Tassone F, Adams P, Hagerman RJ, Hagerman PJ, Rivera SM. Investigation of amygdala volume in men with the fragile X premutation. Brain Imaging Behav. 2011 Dec; 5(4):285-94. PMID: 21786216; PMCID: PMC3982607.
    46. Stöger R, Genereux DP, Hagerman RJ, Hagerman PJ, Tassone F, Laird CD. Testing the FMR1 promoter for mosaicism in DNA methylation among CpG sites, strands, and cells in FMR1-expressing males with fragile X syndrome. PLoS One. 2011; 6(8):e23648. PMID: 21909353; PMCID: PMC3166088.
    47. Hunsaker MR, Greco CM, Spath MA, Smits AP, Navarro CS, Tassone F, Kros JM, Severijnen LA, Berry-Kravis EM, Berman RF, Hagerman PJ, Willemsen R, Hagerman RJ, Hukema RK. Widespread non-central nervous system organ pathology in fragile X premutation carriers with fragile X-associated tremor/ataxia syndrome and CGG knock-in mice. Acta Neuropathol. 2011 Oct; 122(4):467-79. PMID: 21785977; PMCID: PMC3222079.
    48. Hessl D, Wang JM, Schneider A, Koldewyn K, Le L, Iwahashi C, Cheung K, Tassone F, Hagerman PJ, Rivera SM. Decreased fragile X mental retardation protein expression underlies amygdala dysfunction in carriers of the fragile X premutation. Biol Psychiatry. 2011 Nov 01; 70(9):859-65. PMID: 21783174; PMCID: PMC3191264.
    49. Chen L, Hadd A, Sah S, Houghton JF, Filipovic-Sadic S, Zhang W, Hagerman PJ, Tassone F, Latham GJ. High-resolution methylation polymerase chain reaction for fragile X analysis: evidence for novel FMR1 methylation patterns undetected in Southern blot analyses. Genet Med. 2011 Jun; 13(6):528-538. PMID: 21430544; PMCID: PMC4043840.
    50. Hunsaker MR, Greco CM, Tassone F, Berman RF, Willemsen R, Hagerman RJ, Hagerman PJ. Rare intranuclear inclusions in the brains of 3 older adult males with fragile x syndrome: implications for the spectrum of fragile x-associated disorders. J Neuropathol Exp Neurol. 2011 Jun; 70(6):462-9. PMID: 21572337; PMCID: PMC3109086.
    51. Hagerman R, Au J, Hagerman P. FMR1 premutation and full mutation molecular mechanisms related to autism. J Neurodev Disord. 2011 Sep; 3(3):211-24. PMID: 21617890; PMCID: PMC3261276.
    52. Hall DA, Berry-Kravis E, Zhang W, Tassone F, Spector E, Zerbe G, Hagerman PJ, Ouyang B, Leehey MA. FMR1 gray-zone alleles: association with Parkinson's disease in women? Mov Disord. 2011 Aug 15; 26(10):1900-6. PMID: 21567456; PMCID: PMC3934001.
    53. Napoli E, Ross-Inta C, Wong S, Omanska-Klusek A, Barrow C, Iwahashi C, Garcia-Arocena D, Sakaguchi D, Berry-Kravis E, Hagerman R, Hagerman PJ, Giulivi C. Altered zinc transport disrupts mitochondrial protein processing/import in fragile X-associated tremor/ataxia syndrome. Hum Mol Genet. 2011 Aug 01; 20(15):3079-92. PMID: 21558427; PMCID: PMC3131047.
    54. Narcisa V, Aguilar D, Nguyen DV, Campos L, Brodovsky J, White S, Adams P, Tassone F, Hagerman PJ, Hagerman RJ. A Quantitative Assessment of Tremor and Ataxia in Female FMR1 Premutation Carriers Using CATSYS. Curr Gerontol Geriatr Res. 2011; 2011:484713. PMID: 23008705; PMCID: PMC3114433.
    55. Tassone F, De Rubeis S, Carosi C, La Fata G, Serpa G, Raske C, Willemsen R, Hagerman PJ, Bagni C. Differential usage of transcriptional start sites and polyadenylation sites in FMR1 premutation alleles. Nucleic Acids Res. 2011 Aug; 39(14):6172-85. PMID: 21478165; PMCID: PMC3152321.
    56. Hoem G, Raske CR, Garcia-Arocena D, Tassone F, Sanchez E, Ludwig AL, Iwahashi CK, Kumar M, Yang JE, Hagerman PJ. CGG-repeat length threshold for FMR1 RNA pathogenesis in a cellular model for FXTAS. Hum Mol Genet. 2011 Jun 01; 20(11):2161-70. PMID: 21389081; PMCID: PMC3090194.
    57. Greco CM, Navarro CS, Hunsaker MR, Maezawa I, Shuler JF, Tassone F, Delany M, Au JW, Berman RF, Jin LW, Schumann C, Hagerman PJ, Hagerman RJ. Neuropathologic features in the hippocampus and cerebellum of three older men with fragile X syndrome. Mol Autism. 2011 Feb 08; 2(1):2. PMID: 21303513; PMCID: PMC3045897.
    58. Ludwig AL, Hershey JW, Hagerman PJ. Initiation of translation of the FMR1 mRNA Occurs predominantly through 5'-end-dependent ribosomal scanning. J Mol Biol. 2011 Mar 18; 407(1):21-34. PMID: 21237174; PMCID: PMC3046292.
    59. Cunningham CL, Martínez Cerdeño V, Navarro Porras E, Prakash AN, Angelastro JM, Willemsen R, Hagerman PJ, Pessah IN, Berman RF, Noctor SC. Premutation CGG-repeat expansion of the Fmr1 gene impairs mouse neocortical development. Hum Mol Genet. 2011 Jan 01; 20(1):64-79. PMID: 20935171; PMCID: PMC3000676.
    60. Hagerman R, Hoem G, Hagerman P. Fragile X and autism: Intertwined at the molecular level leading to targeted treatments. Mol Autism. 2010 Sep 21; 1(1):12. PMID: 20858229; PMCID: PMC2954865.
    61. Ross-Inta C, Omanska-Klusek A, Wong S, Barrow C, Garcia-Arocena D, Iwahashi C, Berry-Kravis E, Hagerman RJ, Hagerman PJ, Giulivi C. Evidence of mitochondrial dysfunction in fragile X-associated tremor/ataxia syndrome. Biochem J. 2010 Aug 01; 429(3):545-52. PMID: 20513237; PMCID: PMC4011071.
    62. Chen L, Hadd A, Sah S, Filipovic-Sadic S, Krosting J, Sekinger E, Pan R, Hagerman PJ, Stenzel TT, Tassone F, Latham GJ. An information-rich CGG repeat primed PCR that detects the full range of fragile X expanded alleles and minimizes the need for southern blot analysis. J Mol Diagn. 2010 Sep; 12(5):589-600. PMID: 20616364; PMCID: PMC2928422.
    63. Paul R, Pessah IN, Gane L, Ono M, Hagerman PJ, Brunberg JA, Tassone F, Bourgeois JA, Adams PE, Nguyen DV, Hagerman R. Early onset of neurological symptoms in fragile X premutation carriers exposed to neurotoxins. Neurotoxicology. 2010 Aug; 31(4):399-402. PMID: 20466021; PMCID: PMC3918243.
    64. Garcia-Arocena D, Hagerman PJ. Advances in understanding the molecular basis of FXTAS. Hum Mol Genet. 2010 Apr 15; 19(R1):R83-9. PMID: 20430935; PMCID: PMC2875053.
    65. Sellier C, Rau F, Liu Y, Tassone F, Hukema RK, Gattoni R, Schneider A, Richard S, Willemsen R, Elliott DJ, Hagerman PJ, Charlet-Berguerand N. Sam68 sequestration and partial loss of function are associated with splicing alterations in FXTAS patients. EMBO J. 2010 Apr 07; 29(7):1248-61. PMID: 20186122; PMCID: PMC2857464.
    66. Filipovic-Sadic S, Sah S, Chen L, Krosting J, Sekinger E, Zhang W, Hagerman PJ, Stenzel TT, Hadd AG, Latham GJ, Tassone F. A novel FMR1 PCR method for the routine detection of low abundance expanded alleles and full mutations in fragile X syndrome. Clin Chem. 2010 Mar; 56(3):399-408. PMID: 20056738; PMCID: PMC4031651.
    67. Chen Y, Tassone F, Berman RF, Hagerman PJ, Hagerman RJ, Willemsen R, Pessah IN. Murine hippocampal neurons expressing Fmr1 gene premutations show early developmental deficits and late degeneration. Hum Mol Genet. 2010 Jan 01; 19(1):196-208. PMID: 19846466; PMCID: PMC2792156.
    68. Raske C, Hagerman PJ. Molecular pathogenesis of fragile X-associated tremor/ataxia syndrome. J Investig Med. 2009 Dec; 57(8):825-9. PMID: 19794313; PMCID: PMC2787679.
    69. Garcia-Arocena D, Yang JE, Brouwer JR, Tassone F, Iwahashi C, Berry-Kravis EM, Goetz CG, Sumis AM, Zhou L, Nguyen DV, Campos L, Howell E, Ludwig A, Greco C, Willemsen R, Hagerman RJ, Hagerman PJ. Fibroblast phenotype in male carriers of FMR1 premutation alleles. Hum Mol Genet. 2010 Jan 15; 19(2):299-312. PMID: 19864489; PMCID: PMC2796892.
    70. Brega AG, Reynolds A, Bennett RE, Leehey MA, Bounds LS, Cogswell JB, Hagerman RJ, Hagerman PJ, Grigsby J. Functional status of men with the fragile X premutation, with and without the tremor/ataxia syndrome (FXTAS). Int J Geriatr Psychiatry. 2009 Oct; 24(10):1101-9. PMID: 19404994; PMCID: PMC4414034.
    71. Ludwig AL, Raske C, Tassone F, Garcia-Arocena D, Hershey JW, Hagerman PJ. Translation of the FMR1 mRNA is not influenced by AGG interruptions. Nucleic Acids Res. 2009 Nov; 37(20):6896-904. PMID: 19752155; PMCID: PMC2777427.
    72. Hagerman PJ, Stafstrom CE. Origins of epilepsy in fragile X syndrome. Epilepsy Curr. 2009 Jul-Aug; 9(4):108-12. PMID: 19693328; PMCID: PMC2728488.
    73. Dodds ED, Tassone F, Hagerman PJ, Lebrilla CB. Polymerase chain reaction, nuclease digestion, and mass spectrometry based assay for the trinucleotide repeat status of the fragile X mental retardation 1 gene. Anal Chem. 2009 Jul 01; 81(13):5533-40. PMID: 19514725; PMCID: PMC2744861.
    74. Fernandez-Carvajal I, Lopez Posadas B, Pan R, Raske C, Hagerman PJ, Tassone F. Expansion of an FMR1 grey-zone allele to a full mutation in two generations. J Mol Diagn. 2009 Jul; 11(4):306-10. PMID: 19525339; PMCID: PMC2710706.
    75. Iwahashi C, Tassone F, Hagerman RJ, Yasui D, Parrott G, Nguyen D, Mayeur G, Hagerman PJ. A quantitative ELISA assay for the fragile x mental retardation 1 protein. J Mol Diagn. 2009 Jul; 11(4):281-9. PMID: 19460937; PMCID: PMC2710703.
    76. Fernandez-Carvajal I, Walichiewicz P, Xiaosen X, Pan R, Hagerman PJ, Tassone F. Screening for expanded alleles of the FMR1 gene in blood spots from newborn males in a Spanish population. J Mol Diagn. 2009 Jul; 11(4):324-9. PMID: 19460941; PMCID: PMC2710709.
    77. Bourgeois JA, Coffey SM, Rivera SM, Hessl D, Gane LW, Tassone F, Greco C, Finucane B, Nelson L, Berry-Kravis E, Grigsby J, Hagerman PJ, Hagerman RJ. A review of fragile X premutation disorders: expanding the psychiatric perspective. J Clin Psychiatry. 2009 Jun; 70(6):852-62. PMID: 19422761; PMCID: PMC2705685.
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