Karl D Murray

Title(s)Associate Adjunct Professor, MED: Psychiatry & Behav Sci
SchoolSchool of Medicine
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    1. Multiplexed volumetric CLEM enabled by scFvs provides insights into the cytology of cerebellar cortex. Nat Commun. 2024 Aug 05; 15(1):6648. Han X, Lu X, Li PH, Wang S, Schalek R, Meirovitch Y, Lin Z, Adhinarta J, Murray KD, MacNiven LM, Berger DR, Wu Y, Fang T, Meral ES, Asraf S, Ploegh H, Pfister H, Wei D, Jain V, Trimmer JS, Lichtman JW. PMID: 39103318; PMCID: PMC11300613.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Neurosphere culture derived from aged hippocampal dentate gyrus. bioRxiv. 2024 Mar 17. Vafaeva O, Namchaiw P, Murray K, Diaz E, Cheng HJ. PMID: 38559117; PMCID: PMC10980067.
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    3. Electrically silent KvS subunits associate with native Kv2 channels in brain and impact diverse properties of channel function. bioRxiv. 2024 Jan 25. Ferns M, van der List D, Vierra NC, Lacey T, Murray K, Kirmiz M, Stewart RG, Sack JT, Trimmer JS. PMID: 38328147; PMCID: PMC10849721.
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    4. Developing a Toolbox of Antibodies Validated for Array Tomography-Based Imaging of Brain Synapses. eNeuro. 2023 Dec; 10(12). Micheva KD, Gong B, Collman F, Weinberg RJ, Smith SJ, Trimmer JS, Murray KD. PMID: 37945352; PMCID: PMC10748464.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    5. Developing a Toolbox of Antibodies Validated for Array Tomography-Based Imaging of Brain Synapses. bioRxiv. 2023 Nov 08. Micheva KD, Gong B, Collman F, Weinberg RJ, Smith SJ, Trimmer JS, Murray KD. PMID: 37425759; PMCID: PMC10327040.
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    6. High-volume hybridoma sequencing on the NeuroMabSeq platform enables efficient generation of recombinant monoclonal antibodies and scFvs for neuroscience research. Sci Rep. 2023 09 27; 13(1):16200. Mitchell KG, Gong B, Hunter SS, Burkart-Waco D, Gavira-O'Neill CE, Templeton KM, Goethel ME, Bzymek M, MacNiven LM, Murray KD, Settles ML, Froenicke L, Trimmer JS. PMID: 37758930; PMCID: PMC10533561.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    7. NPC1-dependent alterations in KV2.1-CaV1.2 nanodomains drive neuronal death in models of Niemann-Pick Type C disease. Nat Commun. 2023 07 28; 14(1):4553. Casas M, Murray KD, Hino K, Vierra NC, Simó S, Trimmer JS, Dixon RE, Dickson EJ. PMID: 37507375; PMCID: PMC10382591.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    8. NeuroMabSeq: high volume acquisition, processing, and curation of hybridoma sequences and their use in generating recombinant monoclonal antibodies and scFvs for neuroscience research. bioRxiv. 2023 Jun 30. Mitchell KG, Gong B, Hunter SS, Burkart-Waco D, Gavira-O'Neill CE, Templeton KM, Goethel ME, Bzymek M, MacNiven LM, Murray KD, Settles ML, Froenicke L, Trimmer JS. PMID: 37425915; PMCID: PMC10327083.
      View in: PubMed   Mentions:
    9. Global metabolic profiles in a non-human primate model of maternal immune activation: implications for neurodevelopmental disorders. Mol Psychiatry. 2022 12; 27(12):4959-4973. Boktor JC, Adame MD, Rose DR, Schumann CM, Murray KD, Bauman MD, Careaga M, Mazmanian SK, Ashwood P, Needham BD. PMID: 36028571; PMCID: PMC9772216.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    10. Alterations in Retrotransposition, Synaptic Connectivity, and Myelination Implicated by Transcriptomic Changes Following Maternal Immune Activation in Nonhuman Primates. Biol Psychiatry. 2021 05 01; 89(9):896-910. Page NF, Gandal MJ, Estes ML, Cameron S, Buth J, Parhami S, Ramaswami G, Murray K, Amaral DG, Van de Water JA, Schumann CM, Carter CS, Bauman MD, McAllister AK, Geschwind DH. PMID: 33386132; PMCID: PMC8052273.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    11. Age-Related Changes in Synaptic Plasticity Associated with Mossy Fiber Terminal Integration during Adult Neurogenesis. eNeuro. 2020 May/Jun; 7(3). Murray KD, Liu XB, King AN, Luu JD, Cheng HJ. PMID: 32332082; PMCID: PMC7240290.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    12. A toolbox of nanobodies developed and validated for use as intrabodies and nanoscale immunolabels in mammalian brain neurons. Elife. 2019 09 30; 8. Dong JX, Lee Y, Kirmiz M, Palacio S, Dumitras C, Moreno CM, Sando R, Santana LF, Südhof TC, Gong B, Murray KD, Trimmer JS. PMID: 31566565; PMCID: PMC6785268.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    13. Astroglial-targeted expression of the fragile X CGG repeat premutation in mice yields RAN translation, motor deficits and possible evidence for cell-to-cell propagation of FXTAS pathology. Acta Neuropathol Commun. 2019 02 26; 7(1):27. Wenzel HJ, Murray KD, Haify SN, Hunsaker MR, Schwartzer JJ, Kim K, La Spada AR, Sopher BL, Hagerman PJ, Raske C, Severijnen LWFM, Willemsen R, Hukema RK, Berman RF. PMID: 30808398; PMCID: PMC6390634.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    14. A toolbox of IgG subclass-switched recombinant monoclonal antibodies for enhanced multiplex immunolabeling of brain. Elife. 2019 01 22; 8. Andrews NP, Boeckman JX, Manning CF, Nguyen JT, Bechtold H, Dumitras C, Gong B, Nguyen K, van der List D, Murray KD, Engebrecht J, Trimmer JS. PMID: 30667360; PMCID: PMC6377228.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    15. Kv2 Ion Channels Determine the Expression and Localization of the Associated AMIGO-1 Cell Adhesion Molecule in Adult Brain Neurons. Front Mol Neurosci. 2018; 11:1. Bishop HI, Cobb MM, Kirmiz M, Parajuli LK, Mandikian D, Philp AM, Melnik M, Kuja-Panula J, Rauvala H, Shigemoto R, Murray KD, Trimmer JS. PMID: 29403353; PMCID: PMC5780429.
      View in: PubMed   Mentions: 16  
    16. Heterogeneity in Kv2 Channel Expression Shapes Action Potential Characteristics and Firing Patterns in CA1 versus CA2 Hippocampal Pyramidal Neurons. eNeuro. 2017 Jul-Aug; 4(4). Palacio S, Chevaleyre V, Brann DH, Murray KD, Piskorowski RA, Trimmer JS. PMID: 28856240; PMCID: PMC5569380.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    17. Bipolar cell reduction precedes retinal ganglion neuron loss in a complex 1 knockout mouse model. Brain Res. 2017 02 15; 1657:232-244. Song L, Yu A, Murray K, Cortopassi G. PMID: 28027875.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    18. Developing high-quality mouse monoclonal antibodies for neuroscience research - approaches, perspectives and opportunities. N Biotechnol. 2016 Sep 25; 33(5 Pt A):551-64. Gong B, Murray KD, Trimmer JS. PMID: 26644354; PMCID: PMC4884554.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsPHPublic Health
    19. Distinct Cell- and Layer-Specific Expression Patterns and Independent Regulation of Kv2 Channel Subtypes in Cortical Pyramidal Neurons. J Neurosci. 2015 Nov 04; 35(44):14922-42. Bishop HI, Guan D, Bocksteins E, Parajuli LK, Murray KD, Cobb MM, Misonou H, Zito K, Foehring RC, Trimmer JS. PMID: 26538660; PMCID: PMC4635138.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    20. Mitochondrial complex I deficiency leads to inflammation and retinal ganglion cell death in the Ndufs4 mouse. Hum Mol Genet. 2015 May 15; 24(10):2848-60. Yu AK, Song L, Murray KD, van der List D, Sun C, Shen Y, Xia Z, Cortopassi GA. PMID: 25652399; PMCID: PMC4406296.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    21. Neuronal excitability and calcium/calmodulin-dependent protein kinase type II: location, location, location. Epilepsia. 2012 Jun; 53 Suppl 1:45-52. Liu XB, Murray KD. PMID: 22612808.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    22. Abnormal dendrite and spine morphology in primary visual cortex in the CGG knock-in mouse model of the fragile X premutation. Epilepsia. 2012 Jun; 53 Suppl 1:150-60. Berman RF, Murray KD, Arque G, Hunsaker MR, Wenzel HJ. PMID: 22612820; PMCID: PMC4316681.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    23. Sema3E/plexin-D1 mediated epithelial-to-mesenchymal transition in ovarian endometrioid cancer. PLoS One. 2011 Apr 29; 6(4):e19396. Tseng CH, Murray KD, Jou MF, Hsu SM, Cheng HJ, Huang PH. PMID: 21559368; PMCID: PMC3084850.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    24. Low-threshold calcium channel subunit Ca(v) 3.3 is specifically localized in GABAergic neurons of rodent thalamus and cerebral cortex. J Comp Neurol. 2011 Apr 15; 519(6):1181-95. Liu XB, Murray KD, Jones EG. PMID: 21344408.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    25. Molecular correlates of laminar differences in the macaque dorsal lateral geniculate nucleus. J Neurosci. 2008 Nov 12; 28(46):12010-22. Murray KD, Rubin CM, Jones EG, Chalupa LM. PMID: 19005066; PMCID: PMC2613947.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    26. Vesicular glutamate transporters define two sets of glutamatergic afferents to the somatosensory thalamus and two thalamocortical projections in the mouse. J Comp Neurol. 2008 Mar 10; 507(2):1258-76. Graziano A, Liu XB, Murray KD, Jones EG. PMID: 18181146.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    27. Nucleus- and cell-specific gene expression in monkey thalamus. Proc Natl Acad Sci U S A. 2007 Feb 06; 104(6):1989-94. Murray KD, Choudary PV, Jones EG. PMID: 17261798; PMCID: PMC1783903.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    28. Ephrin-As mediate targeting of eye-specific projections to the lateral geniculate nucleus. Nat Neurosci. 2005 Aug; 8(8):1013-21. Huberman AD, Murray KD, Warland DK, Feldheim DA, Chapman B. PMID: 16025110; PMCID: PMC2652399.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    29. Switching of NMDA receptor 2A and 2B subunits at thalamic and cortical synapses during early postnatal development. J Neurosci. 2004 Oct 06; 24(40):8885-95. Liu XB, Murray KD, Jones EG. PMID: 15470155; PMCID: PMC6729956.
      View in: PubMed   Mentions: 155     Fields:    Translation:AnimalsCells
    30. Two epochs in the development of gamma-aminobutyric acidergic neurons in the ferret thalamus. J Comp Neurol. 2003 Aug 11; 463(1):45-65. Hayes SG, Murray KD, Jones EG. PMID: 12811802.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    31. N-methyl-D-aspartate receptor dependent transcriptional regulation of two calcium/calmodulin-dependent protein kinase type II isoforms in rodent cerebral cortex. Neuroscience. 2003; 122(2):407-20. Murray KD, Isackson PJ, Jones EG. PMID: 14614906.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    32. Characterisation of LMD virus-like nanoparticles self-assembled from cationic liposomes, adenovirus core peptide mu and plasmid DNA. Gene Ther. 2002 May; 9(9):564-76. Tagawa T, Manvell M, Brown N, Keller M, Perouzel E, Murray KD, Harbottle RP, Tecle M, Booy F, Brahimi-Horn MC, Coutelle C, Lemoine NR, Alton EW, Miller AD. PMID: 11973632.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    33. Inhibition of polyglutamine aggregation in R6/2 HD brain slices-complex dose-response profiles. Neurobiol Dis. 2001 Dec; 8(6):1017-26. Smith DL, Portier R, Woodman B, Hockly E, Mahal A, Klunk WE, Li XJ, Wanker E, Murray KD, Bates GP. PMID: 11741397.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    34. Enhanced cationic liposome-mediated transfection using the DNA-binding peptide mu (mu) from the adenovirus core. Gene Ther. 2001 Mar; 8(6):453-60. Murray KD, Etheridge CJ, Shah SI, Matthews DA, Russell W, Gurling HM, Miller AD. PMID: 11313824.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    35. Altered mRNA expression for brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase in the hippocampus of patients with intractable temporal lobe epilepsy. J Comp Neurol. 2000 Mar 20; 418(4):411-22. Murray KD, Isackson PJ, Eskin TA, King MA, Montesinos SP, Abraham LA, Roper SN. PMID: 10713570.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    36. Cationic liposome-mediated DNA transfection in organotypic explant cultures of the ventral mesencephalon. Gene Ther. 1999 Feb; 6(2):190-7. Murray KD, McQuillin A, Stewart L, Etheridge CJ, Cooper RG, Miller AD, Gurling HM. PMID: 10435103.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    37. Cell-specific expression of type II calcium/calmodulin-dependent protein kinase isoforms and glutamate receptors in normal and visually deprived lateral geniculate nucleus of monkeys. J Comp Neurol. 1998 Jan 12; 390(2):278-96. Tighilet B, Huntsman MM, Hashikawa T, Murray KD, Isackson PJ, Jones EG. PMID: 9453671.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    38. The messenger RNA encoding VGF, a neuronal peptide precursor, is rapidly regulated in the rat central nervous system by neuronal activity, seizure and lesion. Neuroscience. 1998 Jan; 82(1):7-19. Snyder SE, Cheng HW, Murray KD, Isackson PJ, McNeill TH, Salton SR. PMID: 9483499.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    39. Attenuation of the seizure-induced expression of BDNF mRNA in adult rat brain by an inhibitor of calcium/calmodulin-dependent protein kinases. Eur J Neurosci. 1998 Jan; 10(1):377-87. Murray KD, Hayes VY, Gall CM, Isackson PJ. PMID: 9753146.
      View in: PubMed   Mentions: 6  Translation:AnimalsCells
    40. Seizure-induced alterations of plasma membrane calcium ATPase isoforms 1, 2 and 3 mRNA and protein in rat hippocampus. Brain Res Mol Brain Res. 1997 May; 45(2):230-8. Garcia ML, Murray KD, Garcia VB, Strehler EE, Isackson PJ. PMID: 9149097.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    41. Optimization of liposome mediated transfection of a neuronal cell line. Neuroreport. 1997 Apr 14; 8(6):1481-4. McQuillin A, Murray KD, Etheridge CJ, Stewart L, Cooper RG, Brett PM, Miller AD, Gurling HM. PMID: 9172158.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    42. A metabotropic glutamate receptor agonist regulates neurotrophin messenger RNA in rat forebrain. Neuroscience. 1996 Feb; 70(3):617-30. Murray KD, Wood PL, Rosasco C, Isackson PJ. PMID: 9045076.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    43. Decreased expression of the alpha subunit of Ca2+/ calmodulin-dependent protein kinase type II mRNA in the adult rat CNS following recurrent limbic seizures. Brain Res Mol Brain Res. 1995 Sep; 32(2):221-32. Murray KD, Gall CM, Benson DL, Jones EG, Isackson PJ. PMID: 7500833.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    44. Differential regulation of brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase messenger RNA expression in Alzheimer's disease. Neuroscience. 1994 May; 60(1):37-48. Murray KD, Gall CM, Jones EG, Isackson PJ. PMID: 8052419.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    45. Haloperidol but not clozapine increases neurotensin receptor mRNA levels in rat substantia nigra. J Neurochem. 1993 Sep; 61(3):1141-3. Bolden-Watson C, Watson MA, Murray KD, Isackson PJ, Richelson E. PMID: 8395560.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    46. BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: temporal patterns of induction distinct from NGF. Neuron. 1991 Jun; 6(6):937-48. Isackson PJ, Huntsman MM, Murray KD, Gall CM. PMID: 2054188.
      View in: PubMed   Mentions: 153     Fields:    Translation:AnimalsCells
    47. Seizures and the regulation of neurotrophic factor and neuropeptide gene expression in brain. Epilepsy Res Suppl. 1991; 4:225-45. Gall C, Lauterborn J, Bundman M, Murray K, Isackson P. PMID: 1815605.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    48. Kainic acid-induced seizures stimulate increased expression of nerve growth factor mRNA in rat hippocampus. Brain Res Mol Brain Res. 1991 Jan; 9(1-2):113-23. Gall C, Murray K, Isackson PJ. PMID: 1708074.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells