Joanne Engebrecht

Title(s)Professor, Molecular and Cellular Biology
SchoolCollege of Biological Sciences
Address139H Briggs Hall
CA 95616
Phone530-754-6034
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    Collapse Research 
    Collapse Research Activities and Funding
    Sex-specific regulation of meiosis
    NIH R01GM103860Aug 5, 2013 - Mar 31, 2022
    Role: Principal Investigator
    Analysis of checkpoint function in the germ line.
    NIH R01GM086505Sep 17, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Cell Signaling in Meiosis
    NIH R01GM066124Jul 1, 2002 - Jun 30, 2007
    Role: Principal Investigator
    GENETIC ANALYSIS OF MEIOTIC CHROMOSOME SEGREGATION
    NIH R29GM048639Jan 1, 1993 - Dec 31, 1998
    Role: Principal Investigator
    Training Program in Pharmacological Sciences
    NIH T32GM007518Jul 1, 1977 - Jun 30, 2022
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. 53bp1 mutation enhances brca1 and bard1 embryonic lethality in C. elegans. MicroPubl Biol. 2023; 2023. Hariri S, Li Q, Engebrecht J. PMID: 37581122; PMCID: PMC10423319.
      View in: PubMed   Mentions:
    2. Differential requirement for BRCA1-BARD1 E3 ubiquitin ligase activity in DNA damage repair and meiosis in the Caenorhabditis elegans germ line. PLoS Genet. 2023 01; 19(1):e1010457. Li Q, Kaur A, Okada K, McKenney RJ, Engebrecht J. PMID: 36716349; PMCID: PMC9910797.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    3. Human fasting modulates macrophage function and upregulates multiple bioactive metabolites that extend lifespan in Caenorhabditis elegans: a pilot clinical study. Am J Clin Nutr. 2023 02; 117(2):286-297. Rhodes CH, Zhu C, Agus J, Tang X, Li Q, Engebrecht J, Zivkovic AM. PMID: 36811567; PMCID: PMC10196604.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    4. Inducible degradation of dosage compensation protein DPY-27 facilitates isolation of Caenorhabditis elegans males for molecular and biochemical analyses. G3 (Bethesda). 2022 05 06; 12(5). Li Q, Kaur A, Mallory B, Hariri S, Engebrecht J. PMID: 35404452; PMCID: PMC9073673.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    5. DNA repair, recombination, and damage signaling. Genetics. 2022 02 04; 220(2). Gartner A, Engebrecht J. PMID: 35137093; PMCID: PMC9097270.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    6. BRCA1 and BRCA2 Tumor Suppressor Function in Meiosis. Front Cell Dev Biol. 2021; 9:668309. Li Q, Engebrecht J. PMID: 33996823; PMCID: PMC8121103.
      View in: PubMed   Mentions: 9  
    7. Meiotic Double-Strand Break Processing and Crossover Patterning Are Regulated in a Sex-Specific Manner by BRCA1-BARD1 in Caenorhabditis elegans. Genetics. 2020 10; 216(2):359-379. Li Q, Hariri S, Engebrecht J. PMID: 32796008; PMCID: PMC7536853.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    8. A toolbox of IgG subclass-switched recombinant monoclonal antibodies for enhanced multiplex immunolabeling of brain. Elife. 2019 01 22; 8. Andrews NP, Boeckman JX, Manning CF, Nguyen JT, Bechtold H, Dumitras C, Gong B, Nguyen K, van der List D, Murray KD, Engebrecht J, Trimmer JS. PMID: 30667360; PMCID: PMC6377228.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    9. The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombination under meiotic dysfunction in Caenorhabditis elegans. PLoS Genet. 2018 11; 14(11):e1007701. Li Q, Saito TT, Martinez-Garcia M, Deshong AJ, Nadarajan S, Lawrence KS, Checchi PM, Colaiacovo MP, Engebrecht J. PMID: 30383767; PMCID: PMC6211623.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    10. LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining. J Cell Biol. 2016 Dec 19; 215(6):801-821. Lawrence KS, Tapley EC, Cruz VE, Li Q, Aung K, Hart KC, Schwartz TU, Starr DA, Engebrecht J. PMID: 27956467; PMCID: PMC5166498.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    11. To Break or Not To Break: Sex Chromosome Hemizygosity During Meiosis in Caenorhabditis. Genetics. 2016 11; 204(3):999-1013. Van MV, Larson BJ, Engebrecht J. PMID: 27605052; PMCID: PMC5105874.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    12. Plasticity in the Meiotic Epigenetic Landscape of Sex Chromosomes in Caenorhabditis Species. Genetics. 2016 08; 203(4):1641-58. Larson BJ, Van MV, Nakayama T, Engebrecht J. PMID: 27280692; PMCID: PMC4981267.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    13. DNA damage response and spindle assembly checkpoint function throughout the cell cycle to ensure genomic integrity. PLoS Genet. 2015 Apr; 11(4):e1005150. Lawrence KS, Chau T, Engebrecht J. PMID: 25898113; PMCID: PMC4405263.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    14. The spindle assembly checkpoint: More than just keeping track of the spindle. Trends Cell Mol Biol. 2015; 10:141-150. Lawrence KS, Engebrecht J. PMID: 27667906; PMCID: PMC5033511.
      View in: PubMed   Mentions: 4  
    15. Pseudosynapsis and decreased stringency of meiotic repair pathway choice on the hemizygous sex chromosome of Caenorhabditis elegans males. Genetics. 2014 Jun; 197(2):543-60. Checchi PM, Lawrence KS, Van MV, Larson BJ, Engebrecht J. PMID: 24939994; PMCID: PMC4063914.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    16. Slowing replication in preparation for reduction. PLoS Genet. 2012; 8(5):e1002715. Lawrence KS, Engebrecht J. PMID: 22615580; PMCID: PMC3355076.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    17. Caenorhabditis elegans histone methyltransferase MET-2 shields the male X chromosome from checkpoint machinery and mediates meiotic sex chromosome inactivation. PLoS Genet. 2011 Sep; 7(9):e1002267. Checchi PM, Engebrecht J. PMID: 21909284; PMCID: PMC3164706.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    18. Heteromorphic sex chromosomes: navigating meiosis without a homologous partner. Mol Reprod Dev. 2011 Sep; 78(9):623-32. Checchi PM, Engebrecht J. PMID: 22113949; PMCID: PMC3223601.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    19. Meiotic errors activate checkpoints that improve gamete quality without triggering apoptosis in male germ cells. Curr Biol. 2010 Dec 07; 20(23):2078-89. Jaramillo-Lambert A, Harigaya Y, Vitt J, Villeneuve A, Engebrecht J. PMID: 20970339; PMCID: PMC3005853.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    20. A single unpaired and transcriptionally silenced X chromosome locally precludes checkpoint signaling in the Caenorhabditis elegans germ line. Genetics. 2010 Mar; 184(3):613-28. Jaramillo-Lambert A, Engebrecht J. PMID: 20008570; PMCID: PMC2845332.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    21. Phosphatidylinositol-4,5-bisphosphate and phospholipase D-generated phosphatidic acid specify SNARE-mediated vesicle fusion for prospore membrane formation. Eukaryot Cell. 2009 Aug; 8(8):1094-105. Mendonsa R, Engebrecht J. PMID: 19502581; PMCID: PMC2725554.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    22. Phospholipase D function in Saccharomyces cerevisiae. Biochim Biophys Acta. 2009 Sep; 1791(9):970-4. Mendonsa R, Engebrecht J. PMID: 19416650.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    23. Sorting signals within the Saccharomyces cerevisiae sporulation-specific dityrosine transporter, Dtr1p, C terminus promote Golgi-to-prospore membrane transport. Eukaryot Cell. 2008 Oct; 7(10):1674-84. Morishita M, Engebrecht J. PMID: 18676951; PMCID: PMC2568066.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    24. Snc1p v-SNARE transport to the prospore membrane during yeast sporulation is dependent on endosomal retrieval pathways. Traffic. 2007 Sep; 8(9):1231-45. Morishita M, Mendonsa R, Wright J, Engebrecht J. PMID: 17645731.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    25. SYP-3 restricts synaptonemal complex assembly to bridge paired chromosome axes during meiosis in Caenorhabditis elegans. Genetics. 2007 Aug; 176(4):2015-25. Smolikov S, Eizinger A, Schild-Prufert K, Hurlburt A, McDonald K, Engebrecht J, Villeneuve AM, Colaiácovo MP. PMID: 17565948; PMCID: PMC1950610.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    26. Differential timing of S phases, X chromosome replication, and meiotic prophase in the C. elegans germ line. Dev Biol. 2007 Aug 01; 308(1):206-21. Jaramillo-Lambert A, Ellefson M, Villeneuve AM, Engebrecht J. PMID: 17599823.
      View in: PubMed   Mentions: 132     Fields:    Translation:AnimalsCells
    27. Phospholipase D and the SNARE Sso1p are necessary for vesicle fusion during sporulation in yeast. J Cell Sci. 2006 Apr 01; 119(Pt 7):1406-15. Nakanishi H, Morishita M, Schwartz CL, Coluccio A, Engebrecht J, Neiman AM. PMID: 16554438.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    28. The Arf-GTPase-activating protein Gcs1p is essential for sporulation and regulates the phospholipase D Spo14p. Eukaryot Cell. 2006 Jan; 5(1):112-24. Connolly JE, Engebrecht J. PMID: 16400173; PMCID: PMC1360266.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    29. End3p-mediated endocytosis is required for spore wall formation in Saccharomyces cerevisiae. Genetics. 2005 Aug; 170(4):1561-74. Morishita M, Engebrecht J. PMID: 15944351; PMCID: PMC1237033.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    30. Saccharomyces cerevisiae Sps1p regulates trafficking of enzymes required for spore wall synthesis. Eukaryot Cell. 2005 Mar; 4(3):536-44. Iwamoto MA, Fairclough SR, Rudge SA, Engebrecht J. PMID: 15755916; PMCID: PMC1087804.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    31. Roles of phosphoinositides and of Spo14p (phospholipase D)-generated phosphatidic acid during yeast sporulation. Mol Biol Cell. 2004 Jan; 15(1):207-18. Rudge SA, Sciorra VA, Iwamoto M, Zhou C, Strahl T, Morris AJ, Thorner J, Engebrecht J. PMID: 14528019; PMCID: PMC307541.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    32. Cell signaling in yeast sporulation. Biochem Biophys Res Commun. 2003 Jun 27; 306(2):325-8. Engebrecht J. PMID: 12804565.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    33. Dual role for phosphoinositides in regulation of yeast and mammalian phospholipase D enzymes. J Cell Biol. 2002 Dec 23; 159(6):1039-49. Sciorra VA, Rudge SA, Wang J, McLaughlin S, Engebrecht J, Morris AJ. PMID: 12486109; PMCID: PMC2173982.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    34. Phospholipase D activity is required for suppression of yeast phosphatidylinositol transfer protein defects. Proc Natl Acad Sci U S A. 1998 Oct 13; 95(21):12346-51. Xie Z, Fang M, Rivas MP, Faulkner AJ, Sternweis PC, Engebrecht JA, Bankaitis VA. PMID: 9770489; PMCID: PMC22834.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    35. The yeast MER2 gene is required for chromosome synapsis and the initiation of meiotic recombination. Genetics. 1995 Sep; 141(1):49-59. Rockmill B, Engebrecht JA, Scherthan H, Loidl J, Roeder GS. PMID: 8536989; PMCID: PMC1206739.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    36. ZIP1 is a synaptonemal complex protein required for meiotic chromosome synapsis. Cell. 1993 Feb 12; 72(3):365-78. Sym M, Engebrecht JA, Roeder GS. PMID: 7916652.
      View in: PubMed   Mentions: 313     Fields:    Translation:AnimalsCells
    37. Meiosis-specific RNA splicing in yeast. Cell. 1991 Sep 20; 66(6):1257-68. Engebrecht JA, Voelkel-Meiman K, Roeder GS. PMID: 1840507.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
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