Richard James McKenney

Title(s)Assistant Professor, Molecular and Cellular Biology
SchoolCollege of Biological Sciences
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    Collapse Research 
    Collapse Research Activities and Funding
    Coordination of molecular motor activity in intracellular transport and assembly of cytoskeletal architecture.
    NIH R35GM124889Sep 30, 2017 - Jun 30, 2022
    Role: Principal Investigator
    Regulation of Cytoplasmic Dynein Motility in Neuronal Transport
    NIH R00NS089428Aug 15, 2016 - May 31, 2019
    Role: Principal Investigator
    Regulation of Cytoplasmic Dynein Motility in Neuronal Transport
    NIH K99NS089428Mar 1, 2015 - Feb 29, 2016
    Role: Principal Investigator
    Tuning the Biophysical Properties of Dynein 2 for Intraflagellar Transport
    NIH F32GM096484Feb 1, 2011 - Jan 31, 2014
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tau oligomerization on microtubules in health and disease. Cytoskeleton (Hoboken). 2024 Jan; 81(1):35-40. Ori-McKenney KM, McKenney RJ. PMID: 37747123; PMCID: PMC10841430.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    2. Conserved roles for the dynein intermediate chain and Ndel1 in assembly and activation of dynein. Nat Commun. 2023 09 20; 14(1):5833. Okada K, Iyer BR, Lammers LG, Gutierrez PA, Li W, Markus SM, McKenney RJ. PMID: 37730751; PMCID: PMC10511499.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    3. Control of motor landing and processivity by the CAP-Gly domain in the KIF13B tail. Nat Commun. 2023 08 05; 14(1):4715. Fan X, McKenney RJ. PMID: 37543636; PMCID: PMC10404244.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    4. The Ndc80-Cdt1-Ska1 complex is a central processive kinetochore-microtubule coupling unit. J Cell Biol. 2023 08 07; 222(8). Rahi A, Chakraborty M, Agarwal S, Vosberg KM, Agarwal S, Wang AY, McKenney RJ, Varma D. PMID: 37265445; PMCID: PMC10238862.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    5. Differential requirement for BRCA1-BARD1 E3 ubiquitin ligase activity in DNA damage repair and meiosis in the Caenorhabditis elegans germ line. PLoS Genet. 2023 01; 19(1):e1010457. Li Q, Kaur A, Okada K, McKenney RJ, Engebrecht J. PMID: 36716349; PMCID: PMC9910797.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    6. Conserved Roles for the Dynein Intermediate Chain and Ndel1 in Assembly and Activation of Dynein. bioRxiv. 2023 Jan 14. Okada K, Iyer BR, Lammers LG, Gutierrez P, Li W, Markus SM, McKenney RJ. PMID: 36711700; PMCID: PMC9882231.
      View in: PubMed   Mentions:
    7. Microtubule lattice spacing governs cohesive envelope formation of tau family proteins. Nat Chem Biol. 2022 11; 18(11):1224-1235. Siahaan V, Tan R, Humhalova T, Libusova L, Lacey SE, Tan T, Dacy M, Ori-McKenney KM, McKenney RJ, Braun M, Lansky Z. PMID: 35996000; PMCID: PMC9613621.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    8. Synergistic autoinhibition and activation mechanisms control kinesin-1 motor activity. Cell Rep. 2022 Jun 28; 39(13):111016. Chiba K, Ori-McKenney KM, Niwa S, McKenney RJ. PMID: 35767955; PMCID: PMC9475850.
      View in: PubMed   Mentions: 3     Fields:    
    9. Synergistic autoinhibition and activation mechanisms control kinesin-1 motor activity. Cell Rep. 2022 05 31; 39(9):110900. Chiba K, Ori-McKenney KM, Niwa S, McKenney RJ. PMID: 35649356; PMCID: PMC9365671.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    10. In Vitro and In Vivo Approaches to Study Kinetochore-Microtubule Attachments During Mitosis. Methods Mol Biol. 2022; 2415:123-138. Afreen S, Rahi A, Landeros AG, Chakraborty M, McKenney RJ, Varma D. PMID: 34972950.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    11. A highly conserved 310 helix within the kinesin motor domain is critical for kinesin function and human health. Sci Adv. 2021 04; 7(18). Lam AJ, Rao L, Anazawa Y, Okada K, Chiba K, Dacy M, Niwa S, Gennerich A, Nowakowski DW, McKenney RJ. PMID: 33931448; PMCID: PMC8087401.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    12. Structural stability of SARS-CoV-2 virus like particles degrades with temperature. Biochem Biophys Res Commun. 2021 01 01; 534:343-346. Sharma A, Preece B, Swann H, Fan X, McKenney RJ, Ori-McKenney KM, Saffarian S, Vershinin MD. PMID: 33272571; PMCID: PMC7699159.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCellsPHPublic Health
    13. Structural stability of SARS-CoV-2 degrades with temperature. bioRxiv. 2020 Oct 14. Sharma A, Preece B, Swann H, Fan X, McKenney RJ, Ori-McKenney KM, Saffarian S, Vershinin MD. PMID: 33083798; PMCID: PMC7574253.
      View in: PubMed   Mentions:
    14. New insights into the mechanism of dynein motor regulation by lissencephaly-1. Elife. 2020 07 21; 9. Markus SM, Marzo MG, McKenney RJ. PMID: 32692650; PMCID: PMC7373426.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    15. Absence of SCAPER causes male infertility in humans and Drosophila by modulating microtubule dynamics during meiosis. J Med Genet. 2021 04; 58(4):254-263. Wormser O, Levy Y, Bakhrat A, Bonaccorsi S, Graziadio L, Gatti M, AbuMadighem A, McKenney RJ, Okada K, El Riati S, Har-Vardi I, Huleihel M, Levitas E, Birk OS, Abdu U. PMID: 32527956; PMCID: PMC10405349.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    16. Temperature-dependent activity of kinesins is regulable. Biochem Biophys Res Commun. 2020 07 30; 528(3):528-530. Doval F, Chiba K, McKenney RJ, Ori-McKenney KM, Vershinin MD. PMID: 32507595; PMCID: PMC7366363.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    17. LIS1 cracks open dynein. Nat Cell Biol. 2020 05; 22(5):515-517. McKenney RJ. PMID: 32341546.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    18. A Combinatorial MAP Code Dictates Polarized Microtubule Transport. Dev Cell. 2020 04 06; 53(1):60-72.e4. Monroy BY, Tan TC, Oclaman JM, Han JS, Simó S, Niwa S, Nowakowski DW, McKenney RJ, Ori-McKenney KM. PMID: 32109385; PMCID: PMC7181406.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    19. The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding. Elife. 2020 01 20; 9. Bodrug T, Wilson-Kubalek EM, Nithianantham S, Thompson AF, Alfieri A, Gaska I, Major J, Debs G, Inagaki S, Gutierrez P, Gheber L, McKenney RJ, Sindelar CV, Milligan R, Stumpff J, Rosenfeld SS, Forth ST, Al-Bassam J. PMID: 31958056; PMCID: PMC7015671.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    20. The tail wags the motor. Nat Chem Biol. 2019 11; 15(11):1033-1034. McKenney RJ. PMID: 31501591.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    21. Microtubules gate tau condensation to spatially regulate microtubule functions. Nat Cell Biol. 2019 09; 21(9):1078-1085. Tan R, Lam AJ, Tan T, Han J, Nowakowski DW, Vershinin M, Simó S, Ori-McKenney KM, McKenney RJ. PMID: 31481790; PMCID: PMC6748660.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    22. Disease-associated mutations hyperactivate KIF1A motility and anterograde axonal transport of synaptic vesicle precursors. Proc Natl Acad Sci U S A. 2019 09 10; 116(37):18429-18434. Chiba K, Takahashi H, Chen M, Obinata H, Arai S, Hashimoto K, Oda T, McKenney RJ, Niwa S. PMID: 31455732; PMCID: PMC6744892.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    23. Tau repeat regions contain conserved histidine residues that modulate microtubule-binding in response to changes in pH. J Biol Chem. 2019 05 31; 294(22):8779-8790. Charafeddine RA, Cortopassi WA, Lak P, Tan R, McKenney RJ, Jacobson MP, Barber DL, Wittmann T. PMID: 30992364; PMCID: PMC6552421.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    24. Cdt1 stabilizes kinetochore-microtubule attachments via an Aurora B kinase-dependent mechanism. J Cell Biol. 2018 10 01; 217(10):3446-3463. Agarwal S, Smith KP, Zhou Y, Suzuki A, McKenney RJ, Varma D. PMID: 30154187; PMCID: PMC6168275.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    25. Polarity of Neuronal Membrane Traffic Requires Sorting of Kinesin Motor Cargo during Entry into Dendrites by a Microtubule-Associated Septin. Dev Cell. 2018 08 20; 46(4):518-524. Karasmanis EP, Phan CT, Angelis D, Kesisova IA, Hoogenraad CC, McKenney RJ, Spiliotis ET. PMID: 30130532.
      View in: PubMed   Mentions: 7     Fields:    
    26. Polarity of Neuronal Membrane Traffic Requires Sorting of Kinesin Motor Cargo during Entry into Dendrites by a Microtubule-Associated Septin. Dev Cell. 2018 07 16; 46(2):204-218.e7. Karasmanis EP, Phan CT, Angelis D, Kesisova IA, Hoogenraad CC, McKenney RJ, Spiliotis ET. PMID: 30016622; PMCID: PMC6396981.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    27. Antagonism between the dynein and Ndc80 complexes at kinetochores controls the stability of kinetochore-microtubule attachments during mitosis. J Biol Chem. 2018 07 06; 293(27):10825. Amin MA, McKenney RJ, Varma D. PMID: 29980652; PMCID: PMC6036196.
      View in: PubMed   Mentions: 1     Fields:    
    28. Magnetic Cytoskeleton Affinity Purification of Microtubule Motors Conjugated to Quantum Dots. Bioconjug Chem. 2018 07 18; 29(7):2278-2286. Tjioe M, Ryoo H, Ishitsuka Y, Ge P, Bookwalter C, Huynh W, McKenney RJ, Trybus KM, Selvin PR. PMID: 29932650; PMCID: PMC6452869.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    29. Author Correction: Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility. Nat Struct Mol Biol. 2018 04; 25(4):355. Grotjahn DA, Chowdhury S, Xu Y, McKenney RJ, Schroer TA, Lander GC. PMID: 29476122.
      View in: PubMed   Mentions: 1     Fields:    
    30. Antagonism between the dynein and Ndc80 complexes at kinetochores controls the stability of kinetochore-microtubule attachments during mitosis. J Biol Chem. 2018 04 20; 293(16):5755-5765. Amin MA, McKenney RJ, Varma D. PMID: 29475948; PMCID: PMC5912454.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    31. Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility. Nat Struct Mol Biol. 2018 03; 25(3):203-207. Grotjahn DA, Chowdhury S, Xu Y, McKenney RJ, Schroer TA, Lander GC. PMID: 29416113; PMCID: PMC5969528.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    32. Cooperative Accumulation of Dynein-Dynactin at Microtubule Minus-Ends Drives Microtubule Network Reorganization. Dev Cell. 2018 01 22; 44(2):233-247.e4. Tan R, Foster PJ, Needleman DJ, McKenney RJ. PMID: 29401420; PMCID: PMC6082141.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    33. 15 Regulation of cytoplasmic dynein motility. . 2018 Jan 1; 450-469. McKenney MR. .
      View in: Publisher Site   Mentions:
    34. Differential effects of the dynein-regulatory factor Lissencephaly-1 on processive dynein-dynactin motility. J Biol Chem. 2017 07 21; 292(29):12245-12255. Gutierrez PA, Ackermann BE, Vershinin M, McKenney RJ. PMID: 28576829; PMCID: PMC5519373.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    35. Phosphorylation of β-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis. Neuron. 2016 05 04; 90(3):551-63. Ori-McKenney KM, McKenney RJ, Huang HH, Li T, Meltzer S, Jan LY, Vale RD, Wiita AP, Jan YN. PMID: 27112495; PMCID: PMC4860041.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    36. Tyrosination of α-tubulin controls the initiation of processive dynein-dynactin motility. EMBO J. 2016 06 01; 35(11):1175-85. McKenney RJ, Huynh W, Vale RD, Sirajuddin M. PMID: 26968983; PMCID: PMC4888239.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    37. Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes. Science. 2014 Jul 18; 345(6194):337-41. McKenney RJ, Huynh W, Tanenbaum ME, Bhabha G, Vale RD. PMID: 25035494; PMCID: PMC4224444.
      View in: PubMed   Mentions: 273     Fields:    Translation:HumansAnimalsCells
    38. Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains. Elife. 2013 Sep 03; 2:e00943. Tanenbaum ME, Vale RD, McKenney RJ. PMID: 24015359; PMCID: PMC3762337.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    39. Multiple modes of cytoplasmic dynein regulation. Nat Cell Biol. 2012 Feb 29; 14(3):224-30. Vallee RB, McKenney RJ, Ori-McKenney KM. PMID: 22373868.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    40. 16 Studies of Lissencephaly and Neurodegenerative Disease Reveal Novel Aspects of Cytoplasmic Dynein Regulation. . 2012 Jan 1; 440-453. Ori-McKenney OK, McKenney MR, Vallee VR. .
      View in: Publisher Site   Mentions:
    41. Mechanical stochastic tug-of-war models cannot explain bidirectional lipid-droplet transport. Proc Natl Acad Sci U S A. 2011 Nov 22; 108(47):18960-5. Kunwar A, Tripathy SK, Xu J, Mattson MK, Anand P, Sigua R, Vershinin M, McKenney RJ, Yu CC, Mogilner A, Gross SP. PMID: 22084076; PMCID: PMC3223464.
      View in: PubMed   Mentions: 77     Fields:    
    42. High-resolution imaging reveals indirect coordination of opposite motors and a role for LIS1 in high-load axonal transport. J Cell Biol. 2011 Oct 17; 195(2):193-201. Yi JY, Ori-McKenney KM, McKenney RJ, Vershinin M, Gross SP, Vallee RB. PMID: 22006948; PMCID: PMC3198168.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    43. Mutually exclusive cytoplasmic dynein regulation by NudE-Lis1 and dynactin. J Biol Chem. 2011 Nov 11; 286(45):39615-22. McKenney RJ, Weil SJ, Scherer J, Vallee RB. PMID: 21911489; PMCID: PMC3234784.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    44. LIS1 and NudE induce a persistent dynein force-producing state. Cell. 2010 Apr 16; 141(2):304-14. McKenney RJ, Vershinin M, Kunwar A, Vallee RB, Gross SP. PMID: 20403325; PMCID: PMC2881166.
      View in: PubMed   Mentions: 195     Fields:    Translation:HumansAnimals
    45. NudE and NudEL are required for mitotic progression and are involved in dynein recruitment to kinetochores. J Cell Biol. 2007 Aug 13; 178(4):583-94. Stehman SA, Chen Y, McKenney RJ, Vallee RB. PMID: 17682047; PMCID: PMC2064466.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    46. Expression patterns of LIS1, dynein and their interaction partners dynactin, NudE, NudEL and NudC in human gliomas suggest roles in invasion and proliferation. Acta Neuropathol. 2007 May; 113(5):591-9. Suzuki SO, McKenney RJ, Mawatari SY, Mizuguchi M, Mikami A, Iwaki T, Goldman JE, Canoll P, Vallee RB. PMID: 17221205.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    47. Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage. Mutat Res. 2006 Apr 11; 596(1-2):166-76. Bahassi el M, Myer DL, McKenney RJ, Hennigan RF, Stambrook PJ. PMID: 16481012.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
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