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Richard James Mckenney

Title(s)Assistant Professor, Molecular and Cellular Biology
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    Collapse Research 
    Collapse Research Activities and Funding
    Coordination of molecular motor activity in intracellular transport and assembly of cytoskeletal architecture.
    NIH/NIGMS R35GM124889Sep 30, 2017 - Jun 30, 2022
    Role: Principal Investigator
    Regulation of Cytoplasmic Dynein Motility in Neuronal Transport
    NIH/NINDS R00NS089428Aug 15, 2016 - May 31, 2019
    Role: Principal Investigator
    Regulation of Cytoplasmic Dynein Motility in Neuronal Transport
    NIH/NINDS K99NS089428Mar 1, 2015 - Feb 28, 2017
    Role: Principal Investigator
    Tuning the Biophysical Properties of Dynein 2 for Intraflagellar Transport
    NIH/NIGMS F32GM096484Feb 1, 2011 - Jan 31, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ori-McKenney KM, McKenney RJ, Huang HH, Li T, Meltzer S, Jan LY, Vale RD, Wiita AP, Jan YN. Phosphorylation of ß-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis. Neuron. 2016 05 04; 90(3):551-63. PMID: 27112495; PMCID: PMC4860041 [Available on 05/04/17].
    2. McKenney RJ, Huynh W, Vale RD, Sirajuddin M. Tyrosination of a-tubulin controls the initiation of processive dynein-dynactin motility. EMBO J. 2016 06 01; 35(11):1175-85. PMID: 26968983.
      View in: PubMed
    3. McKenney RJ, Huynh W, Tanenbaum ME, Bhabha G, Vale RD. Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes. Science. 2014 Jul 18; 345(6194):337-41. PMID: 25035494; PMCID: PMC4224444.
    4. Tanenbaum ME, Vale RD, McKenney RJ. Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains. Elife. 2013 Sep 03; 2:e00943. PMID: 24015359; PMCID: PMC3762337.
    5. Vallee RB, McKenney RJ, Ori-McKenney KM. Multiple modes of cytoplasmic dynein regulation. Nat Cell Biol. 2012 Feb 29; 14(3):224-30. PMID: 22373868.
      View in: PubMed
    6. Kunwar A, Tripathy SK, Xu J, Mattson MK, Anand P, Sigua R, Vershinin M, McKenney RJ, Yu CC, Mogilner A, Gross SP. Mechanical stochastic tug-of-war models cannot explain bidirectional lipid-droplet transport. Proc Natl Acad Sci U S A. 2011 Nov 22; 108(47):18960-5. PMID: 22084076; PMCID: PMC3223464.
    7. Yi JY, Ori-McKenney KM, McKenney RJ, Vershinin M, Gross SP, Vallee RB. High-resolution imaging reveals indirect coordination of opposite motors and a role for LIS1 in high-load axonal transport. J Cell Biol. 2011 Oct 17; 195(2):193-201. PMID: 22006948; PMCID: PMC3198168.
    8. McKenney RJ, Weil SJ, Scherer J, Vallee RB. Mutually exclusive cytoplasmic dynein regulation by NudE-Lis1 and dynactin. J Biol Chem. 2011 Nov 11; 286(45):39615-22. PMID: 21911489; PMCID: PMC3234784.
    9. McKenney RJ, Vershinin M, Kunwar A, Vallee RB, Gross SP. LIS1 and NudE induce a persistent dynein force-producing state. Cell. 2010 Apr 16; 141(2):304-14. PMID: 20403325; PMCID: PMC2881166.
    10. Stehman SA, Chen Y, McKenney RJ, Vallee RB. NudE and NudEL are required for mitotic progression and are involved in dynein recruitment to kinetochores. J Cell Biol. 2007 Aug 13; 178(4):583-94. PMID: 17682047; PMCID: PMC2064466.
    11. Suzuki SO, McKenney RJ, Mawatari SY, Mizuguchi M, Mikami A, Iwaki T, Goldman JE, Canoll P, Vallee RB. Expression patterns of LIS1, dynein and their interaction partners dynactin, NudE, NudEL and NudC in human gliomas suggest roles in invasion and proliferation. Acta Neuropathol. 2007 May; 113(5):591-9. PMID: 17221205.
      View in: PubMed
    12. Bahassi el M, Myer DL, McKenney RJ, Hennigan RF, Stambrook PJ. Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage. Mutat Res. 2006 Apr 11; 596(1-2):166-76. PMID: 16481012.
      View in: PubMed