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Richard Mckenney

Title(s)Assistant Professor, Molecular and Cellular Biology
SchoolUniversity of California, Davis
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    Coordination of molecular motor activity in intracellular transport and assembly of cytoskeletal architecture.
    NIH/NIGMS R35GM124889Sep 30, 2017 - Jun 30, 2022
    Role: Principal Investigator
    Regulation of Cytoplasmic Dynein Motility in Neuronal Transport
    NIH/NINDS R00NS089428Aug 15, 2016 - May 31, 2019
    Role: Principal Investigator
    Regulation of Cytoplasmic Dynein Motility in Neuronal Transport
    NIH/NINDS K99NS089428Mar 1, 2015 - Feb 28, 2017
    Role: Principal Investigator
    Tuning the Biophysical Properties of Dynein 2 for Intraflagellar Transport
    NIH/NIGMS F32GM096484Feb 1, 2011 - Jan 31, 2014
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. New insights into the mechanism of dynein motor regulation by lissencephaly-1. Elife. 2020 Jul 21; 9. Markus SM, Marzo MG, McKenney RJ. PMID: 32692650.
      View in: PubMed   Mentions:    Fields:    
    2. Absence of SCAPER causes male infertility in humans and Drosophila by modulating microtubule dynamics during meiosis. J Med Genet. 2020 Jun 11. Wormser O, Levy Y, Bakhrat A, Bonaccorsi S, Graziadio L, Gatti M, AbuMadighem A, McKenney RJ, Okada K, El Riati S, Har-Vardi I, Huleihel M, Levitas E, Birk OS, Abdu U. PMID: 32527956.
      View in: PubMed   Mentions:    Fields:    
    3. Temperature-dependent activity of kinesins is regulable. Biochem Biophys Res Commun. 2020 Jul 30; 528(3):528-530. Doval F, Chiba K, McKenney RJ, Ori-McKenney KM, Vershinin MD. PMID: 32507595.
      View in: PubMed   Mentions:    Fields:    
    4. LIS1 cracks open dynein. Nat Cell Biol. 2020 05; 22(5):515-517. McKenney RJ. PMID: 32341546.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    5. A Combinatorial MAP Code Dictates Polarized Microtubule Transport. Dev Cell. 2020 Apr 06; 53(1):60-72.e4. Monroy BY, Tan TC, Oclaman JM, Han JS, Simó S, Niwa S, Nowakowski DW, McKenney RJ, Ori-McKenney KM. PMID: 32109385.
      View in: PubMed   Mentions: 2     Fields:    
    6. The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding. Elife. 2020 Jan 20; 9. Bodrug T, Wilson-Kubalek EM, Nithianantham S, Thompson AF, Alfieri A, Gaska I, Major J, Debs G, Inagaki S, Gutierrez P, Gheber L, McKenney RJ, Sindelar CV, Milligan R, Stumpff J, Rosenfeld SS, Forth ST, Al-Bassam J. PMID: 31958056.
      View in: PubMed   Mentions:    Fields:    
    7. The tail wags the motor. Nat Chem Biol. 2019 11; 15(11):1033-1034. McKenney RJ. PMID: 31501591.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    8. Microtubules gate tau condensation to spatially regulate microtubule functions. Nat Cell Biol. 2019 09; 21(9):1078-1085. Tan R, Lam AJ, Tan T, Han J, Nowakowski DW, Vershinin M, Simó S, Ori-McKenney KM, McKenney RJ. PMID: 31481790.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    9. Disease-associated mutations hyperactivate KIF1A motility and anterograde axonal transport of synaptic vesicle precursors. Proc Natl Acad Sci U S A. 2019 09 10; 116(37):18429-18434. Chiba K, Takahashi H, Chen M, Obinata H, Arai S, Hashimoto K, Oda T, McKenney RJ, Niwa S. PMID: 31455732.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. Tau repeat regions contain conserved histidine residues that modulate microtubule-binding in response to changes in pH. J Biol Chem. 2019 05 31; 294(22):8779-8790. Charafeddine RA, Cortopassi WA, Lak P, Tan R, McKenney RJ, Jacobson MP, Barber DL, Wittmann T. PMID: 30992364.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. Cdt1 stabilizes kinetochore-microtubule attachments via an Aurora B kinase-dependent mechanism. J Cell Biol. 2018 10 01; 217(10):3446-3463. Agarwal S, Smith KP, Zhou Y, Suzuki A, McKenney RJ, Varma D. PMID: 30154187.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    12. Polarity of Neuronal Membrane Traffic Requires Sorting of Kinesin Motor Cargo during Entry into Dendrites by a Microtubule-Associated Septin. Dev Cell. 2018 08 20; 46(4):518-524. Karasmanis EP, Phan CT, Angelis D, Kesisova IA, Hoogenraad CC, McKenney RJ, Spiliotis ET. PMID: 30130532.
      View in: PubMed   Mentions:    Fields:    
    13. Polarity of Neuronal Membrane Traffic Requires Sorting of Kinesin Motor Cargo during Entry into Dendrites by a Microtubule-Associated Septin. Dev Cell. 2018 07 16; 46(2):204-218.e7. Karasmanis EP, Phan CT, Angelis D, Kesisova IA, Hoogenraad CC, McKenney RJ, Spiliotis ET. PMID: 30016622.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    14. Antagonism between the dynein and Ndc80 complexes at kinetochores controls the stability of kinetochore-microtubule attachments during mitosis. J Biol Chem. 2018 07 06; 293(27):10825. Amin MA, McKenney RJ, Varma D. PMID: 29980652.
      View in: PubMed   Mentions:    Fields:    
    15. Magnetic Cytoskeleton Affinity Purification of Microtubule Motors Conjugated to Quantum Dots. Bioconjug Chem. 2018 07 18; 29(7):2278-2286. Tjioe M, Ryoo H, Ishitsuka Y, Ge P, Bookwalter C, Huynh W, McKenney RJ, Trybus KM, Selvin PR. PMID: 29932650.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    16. Author Correction: Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility. Nat Struct Mol Biol. 2018 04; 25(4):355. Grotjahn DA, Chowdhury S, Xu Y, McKenney RJ, Schroer TA, Lander GC. PMID: 29476122.
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    17. Antagonism between the dynein and Ndc80 complexes at kinetochores controls the stability of kinetochore-microtubule attachments during mitosis. J Biol Chem. 2018 04 20; 293(16):5755-5765. Amin MA, McKenney RJ, Varma D. PMID: 29475948.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    18. Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility. Nat Struct Mol Biol. 2018 03; 25(3):203-207. Grotjahn DA, Chowdhury S, Xu Y, McKenney RJ, Schroer TA, Lander GC. PMID: 29416113.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    19. Cooperative Accumulation of Dynein-Dynactin at Microtubule Minus-Ends Drives Microtubule Network Reorganization. Dev Cell. 2018 01 22; 44(2):233-247.e4. Tan R, Foster PJ, Needleman DJ, McKenney RJ. PMID: 29401420.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    20. 15 Regulation of cytoplasmic dynein motility. . 2018 Jan 1; 450-469. Richard J. McKenney. .
      View in: Publisher Site   Mentions:
    21. Differential effects of the dynein-regulatory factor Lissencephaly-1 on processive dynein-dynactin motility. J Biol Chem. 2017 07 21; 292(29):12245-12255. Gutierrez PA, Ackermann BE, Vershinin M, McKenney RJ. PMID: 28576829.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    22. Phosphorylation of ß-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis. Neuron. 2016 05 04; 90(3):551-63. Ori-McKenney KM, McKenney RJ, Huang HH, Li T, Meltzer S, Jan LY, Vale RD, Wiita AP, Jan YN. PMID: 27112495.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    23. Tyrosination of a-tubulin controls the initiation of processive dynein-dynactin motility. EMBO J. 2016 06 01; 35(11):1175-85. McKenney RJ, Huynh W, Vale RD, Sirajuddin M. PMID: 26968983.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    24. Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes. Science. 2014 Jul 18; 345(6194):337-41. McKenney RJ, Huynh W, Tanenbaum ME, Bhabha G, Vale RD. PMID: 25035494.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    25. Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains. Elife. 2013 Sep 03; 2:e00943. Tanenbaum ME, Vale RD, McKenney RJ. PMID: 24015359.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    26. Multiple modes of cytoplasmic dynein regulation. Nat Cell Biol. 2012 Feb 29; 14(3):224-30. Vallee RB, McKenney RJ, Ori-McKenney KM. PMID: 22373868.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    27. 16 Studies of Lissencephaly and Neurodegenerative Disease Reveal Novel Aspects of Cytoplasmic Dynein Regulation. . 2012 Jan 1; 440-453. Kassandra M. Ori-McKenney, Richard J. McKenney, Richard B. Vallee. .
      View in: Publisher Site   Mentions:
    28. Mechanical stochastic tug-of-war models cannot explain bidirectional lipid-droplet transport. Proc Natl Acad Sci U S A. 2011 Nov 22; 108(47):18960-5. Kunwar A, Tripathy SK, Xu J, Mattson MK, Anand P, Sigua R, Vershinin M, McKenney RJ, Yu CC, Mogilner A, Gross SP. PMID: 22084076.
      View in: PubMed   Mentions: 46     Fields:    
    29. High-resolution imaging reveals indirect coordination of opposite motors and a role for LIS1 in high-load axonal transport. J Cell Biol. 2011 Oct 17; 195(2):193-201. Yi JY, Ori-McKenney KM, McKenney RJ, Vershinin M, Gross SP, Vallee RB. PMID: 22006948.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    30. Mutually exclusive cytoplasmic dynein regulation by NudE-Lis1 and dynactin. J Biol Chem. 2011 Nov 11; 286(45):39615-22. McKenney RJ, Weil SJ, Scherer J, Vallee RB. PMID: 21911489.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    31. LIS1 and NudE induce a persistent dynein force-producing state. Cell. 2010 Apr 16; 141(2):304-14. McKenney RJ, Vershinin M, Kunwar A, Vallee RB, Gross SP. PMID: 20403325.
      View in: PubMed   Mentions: 156     Fields:    Translation:HumansAnimals
    32. NudE and NudEL are required for mitotic progression and are involved in dynein recruitment to kinetochores. J Cell Biol. 2007 Aug 13; 178(4):583-94. Stehman SA, Chen Y, McKenney RJ, Vallee RB. PMID: 17682047.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    33. Expression patterns of LIS1, dynein and their interaction partners dynactin, NudE, NudEL and NudC in human gliomas suggest roles in invasion and proliferation. Acta Neuropathol. 2007 May; 113(5):591-9. Suzuki SO, McKenney RJ, Mawatari SY, Mizuguchi M, Mikami A, Iwaki T, Goldman JE, Canoll P, Vallee RB. PMID: 17221205.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    34. Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage. Mutat Res. 2006 Apr 11; 596(1-2):166-76. Bahassi el M, Myer DL, McKenney RJ, Hennigan RF, Stambrook PJ. PMID: 16481012.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
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