Jawdat M Al-Bassam

Title(s)Associate Professor, Molecular and Cellular Biology
SchoolCollege of Biological Sciences
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    Mechanisms of Tubulin dimer Regulatory Pathways and their impact on Microtubule Function.
    NIH R01GM110283Jan 1, 2015 - May 31, 2024
    Role: Principal Investigator
    Microtubule Polymerization and Depolymerization Mechanisms by Conserved Proteins
    NIH R00GM084292Apr 1, 2008 - Aug 31, 2014
    Role: Principal Investigator
    Microtubule Polymerization and Depolymerization Mechanisms by Conserved Proteins
    NIH K99GM084292Apr 1, 2008 - Mar 31, 2011
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cryo-EM structures of the tubulin cofactors reveal the molecular basis for the biogenesis of alpha/beta-tubulin. bioRxiv. 2024 Jan 31. Taheri A, Wang Z, Singal B, Guo F, Al-Bassam J. PMID: 38405852; PMCID: PMC10889022.
      View in: PubMed   Mentions:
    2. The kinesin-5 tail and bipolar minifilament domains are the origin of its microtubule crosslinking and sliding activity. Mol Biol Cell. 2023 10 01; 34(11):ar111. Nithianantham S, Iwanski MK, Gaska I, Pandey H, Bodrug T, Inagaki S, Major J, Brouhard GJ, Gheber L, Rosenfeld SS, Forth S, Hendricks AG, Al-Bassam J. PMID: 37610838; PMCID: PMC10559304.
      View in: PubMed   Mentions:    Fields:    
    3. Flexible microtubule anchoring modulates the bi-directional motility of the kinesin-5 Cin8. Cell Mol Life Sci. 2021 Aug; 78(16):6051-6068. Pandey H, Singh SK, Sadan M, Popov M, Singh M, Davidov G, Inagaki S, Al-Bassam J, Zarivach R, Rosenfeld SS, Gheber L. PMID: 34274977.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    4. Drag-induced directionality switching of kinesin-5 Cin8 revealed by cluster-motility analysis. Sci Adv. 2021 02; 7(6). Pandey H, Reithmann E, Goldstein-Levitin A, Al-Bassam J, Frey E, Gheber L. PMID: 33547070; PMCID: PMC7864582.
      View in: PubMed   Mentions: 5     Fields:    
    5. The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding. Elife. 2020 01 20; 9. Bodrug T, Wilson-Kubalek EM, Nithianantham S, Thompson AF, Alfieri A, Gaska I, Major J, Debs G, Inagaki S, Gutierrez P, Gheber L, McKenney RJ, Sindelar CV, Milligan R, Stumpff J, Rosenfeld SS, Forth ST, Al-Bassam J. PMID: 31958056; PMCID: PMC7015671.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    6. Microtubule polymerase and processive plus-end tracking functions originate from distinct features within TOG domain arrays. Mol Biol Cell. 2019 06 01; 30(12):1490-1504. Cook BD, Chang F, Flor-Parra I, Al-Bassam J. PMID: 30969896; PMCID: PMC6724690.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    7. Malleable folding of coiled-coils regulates kinesin-3 dimerization. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):12845-12847. Al-Bassam J, Nithianantham S. PMID: 30530652; PMCID: PMC6304974.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    8. Structural basis of tubulin recruitment and assembly by microtubule polymerases with tumor overexpressed gene (TOG) domain arrays. Elife. 2018 11 13; 7. Nithianantham S, Cook BD, Beans M, Guo F, Chang F, Al-Bassam J. PMID: 30422110; PMCID: PMC6251626.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    9. Structural basis for disassembly of katanin heterododecamers. J Biol Chem. 2018 07 06; 293(27):10590-10605. Nithianantham S, McNally FJ, Al-Bassam J. PMID: 29752405; PMCID: PMC6036222.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    10. Bidirectional motility of kinesin-5 motor proteins: structural determinants, cumulative functions and physiological roles. Cell Mol Life Sci. 2018 05; 75(10):1757-1771. Singh SK, Pandey H, Al-Bassam J, Gheber L. PMID: 29397398.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    11. Revisiting the tubulin cofactors and Arl2 in the regulation of soluble αβ-tubulin pools and their effect on microtubule dynamics. Mol Biol Cell. 2017 Feb 01; 28(3):359-363. Al-Bassam J. PMID: 28137948; PMCID: PMC5341719.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    12. A potential physiological role for bi-directional motility and motor clustering of mitotic kinesin-5 Cin8 in yeast mitosis. J Cell Sci. 2017 02 15; 130(4):725-734. Shapira O, Goldstein A, Al-Bassam J, Gheber L. PMID: 28069834; PMCID: PMC5339886.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    13. Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble αβ-tubulin pool for microtubule dynamics. Elife. 2015 Jul 24; 4. Nithianantham S, Le S, Seto E, Jia W, Leary J, Corbett KD, Moore JK, Al-Bassam J. PMID: 26208336; PMCID: PMC4574351.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    14. Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers. Elife. 2014 Apr 08; 3:e02217. Scholey JE, Nithianantham S, Scholey JM, Al-Bassam J. PMID: 24714498; PMCID: PMC3978770.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    15. Reconstituting dynamic microtubule polymerization regulation by TOG domain proteins. Methods Enzymol. 2014; 540:131-48. Al-Bassam J. PMID: 24630105.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    16. α-Tubulin acetylation from the inside out. Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48):19515-6. Al-Bassam J, Corbett KD. PMID: 23150594; PMCID: PMC3511746.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    17. Fission yeast Alp14 is a dose-dependent plus end-tracking microtubule polymerase. Mol Biol Cell. 2012 Aug; 23(15):2878-90. Al-Bassam J, Kim H, Flor-Parra I, Lal N, Velji H, Chang F. PMID: 22696680; PMCID: PMC3408415.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    18. Regulation of microtubule dynamics by TOG-domain proteins XMAP215/Dis1 and CLASP. Trends Cell Biol. 2011 Oct; 21(10):604-14. Al-Bassam J, Chang F. PMID: 21782439; PMCID: PMC3202638.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    19. Molecular structures and interactions in the yeast kinetochore. Cold Spring Harb Symp Quant Biol. 2010; 75:395-401. Cho US, Corbett KD, Al-Bassam J, Bellizzi JJ, De Wulf P, Espelin CW, Miranda JJ, Simons K, Wei RR, Sorger PK, Harrison SC. PMID: 21467141; PMCID: PMC3207249.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    20. CLASP promotes microtubule rescue by recruiting tubulin dimers to the microtubule. Dev Cell. 2010 Aug 17; 19(2):245-58. Al-Bassam J, Kim H, Brouhard G, van Oijen A, Harrison SC, Chang F. PMID: 20708587; PMCID: PMC3156696.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    21. XMAP215 is a processive microtubule polymerase. Cell. 2008 Jan 11; 132(1):79-88. Brouhard GJ, Stear JH, Noetzel TL, Al-Bassam J, Kinoshita K, Harrison SC, Howard J, Hyman AA. PMID: 18191222; PMCID: PMC2311386.
      View in: PubMed   Mentions: 288     Fields:    Translation:AnimalsCells
    22. Analysis of the weak interactions of ADP-Unc104 and ADP-kinesin with microtubules and their inhibition by MAP2c. Cell Motil Cytoskeleton. 2007 May; 64(5):377-89. Al-Bassam J, Roger B, Halpain S, Milligan RA. PMID: 17326138.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    23. Crystal structure of a TOG domain: conserved features of XMAP215/Dis1-family TOG domains and implications for tubulin binding. Structure. 2007 Mar; 15(3):355-62. Al-Bassam J, Larsen NA, Hyman AA, Harrison SC. PMID: 17355870.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    24. Structural analysis of Bub3 interactions in the mitotic spindle checkpoint. Proc Natl Acad Sci U S A. 2007 Jan 23; 104(4):1201-6. Larsen NA, Al-Bassam J, Wei RR, Harrison SC. PMID: 17227844; PMCID: PMC1770893.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    25. The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment. Nat Struct Mol Biol. 2007 Jan; 14(1):54-9. Wei RR, Al-Bassam J, Harrison SC. PMID: 17195848.
      View in: PubMed   Mentions: 195     Fields:    Translation:HumansCells
    26. Binding-induced stabilization and assembly of the phage P22 tail accessory factor gp4. J Mol Biol. 2006 Oct 20; 363(2):558-76. Olia AS, Al-Bassam J, Winn-Stapley DA, Joss L, Casjens SR, Cingolani G. PMID: 16970964.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    27. Stu2p binds tubulin and undergoes an open-to-closed conformational change. J Cell Biol. 2006 Mar 27; 172(7):1009-22. Al-Bassam J, van Breugel M, Harrison SC, Hyman A. PMID: 16567500; PMCID: PMC2063759.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    28. Bacteriophage P22 tail accessory factor GP26 is a long triple-stranded coiled-coil. J Biol Chem. 2005 Feb 18; 280(7):5929-33. Andrews D, Butler JS, Al-Bassam J, Joss L, Winn-Stapley DA, Casjens S, Cingolani G. PMID: 15591072.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    29. MAP2c, but not tau, binds and bundles F-actin via its microtubule binding domain. Curr Biol. 2004 Mar 09; 14(5):363-71. Roger B, Al-Bassam J, Dehmelt L, Milligan RA, Halpain S. PMID: 15028210.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    30. Distinct conformations of the kinesin Unc104 neck regulate a monomer to dimer motor transition. J Cell Biol. 2003 Nov 24; 163(4):743-53. Al-Bassam J, Cui Y, Klopfenstein D, Carragher BO, Vale RD, Milligan RA. PMID: 14638858; PMCID: PMC2173678.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    31. MAP2 and tau bind longitudinally along the outer ridges of microtubule protofilaments. J Cell Biol. 2002 Jun 24; 157(7):1187-96. Al-Bassam J, Ozer RS, Safer D, Halpain S, Milligan RA. PMID: 12082079; PMCID: PMC2173547.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansAnimalsCells
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