Jonathan M Scholey

InstitutionUniversity of California Davis
DepartmentMolecular and Cellular Biology
CA 95616
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    Collapse Research 
    Collapse Research Activities and Funding
    Dynamics and Mechanics of Mitosis in Drosophila: Mechanisms of Anaphase B
    NIH/NIGMS R01GM055507Jul 1, 1997 - Jun 30, 2014
    Role: Principal Investigator
    NIH/NIAMS R13AR044448Jul 1, 1996 - Jun 30, 1997
    Role: Principal Investigator
    Intraflagellar Transport Motors in C. elegans neurons
    NIH/NIGMS R01GM050718May 1, 1994 - Mar 31, 2011
    Role: Principal Investigator
    NIH/NIGMS R01GM046376Jul 1, 1991 - Jun 30, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Khan S, Scholey JM. Assembly, Functions and Evolution of Archaella, Flagella and Cilia. Curr Biol. 2018 Mar 19; 28(6):R278-R292. PMID: 29558648.
      View in: PubMed
    2. Prevo B, Scholey JM, Peterman EJG. Intraflagellar transport: mechanisms of motor action, cooperation, and cargo delivery. FEBS J. 2017 09; 284(18):2905-2931. PMID: 28342295.
      View in: PubMed
    3. Scholey JM, Civelekoglu-Scholey G, Brust-Mascher I. Anaphase B. Biology (Basel). 2016 Dec 08; 5(4). PMID: 27941648.
      View in: PubMed
    4. Prevo B, Mangeol P, Oswald F, Scholey JM, Peterman EJ. Functional differentiation of cooperating kinesin-2 motors orchestrates cargo import and transport in C. elegans cilia. Nat Cell Biol. 2015 Dec; 17(12):1536-45. PMID: 26523365.
      View in: PubMed
    5. Brust-Mascher I, Civelekoglu-Scholey G, Scholey JM. Mechanism for Anaphase B: Evaluation of "Slide-and-Cluster" versus "Slide-and-Flux-or-Elongate" Models. Biophys J. 2015 Apr 21; 108(8):2007-18. PMID: 25902440; PMCID: PMC4407247.
    6. Wang H, Brust-Mascher I, Scholey JM. The microtubule cross-linker Feo controls the midzone stability, motor composition, and elongation of the anaphase B spindle in Drosophila embryos. Mol Biol Cell. 2015 Apr 15; 26(8):1452-62. PMID: 25694445; PMCID: PMC4395126.
    7. Wang H, Brust-Mascher I, Scholey JM. Sliding filaments and mitotic spindle organization. Nat Cell Biol. 2014 Aug; 16(8):737-9. PMID: 25082196.
      View in: PubMed
    8. Scholey JE, Nithianantham S, Scholey JM, Al-Bassam J. Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers. Elife. 2014 Apr 08; 3:e02217. PMID: 24714498; PMCID: PMC3978770.
    9. Brust-Mascher I, Civelekoglu-Scholey G, Scholey JM. Analysis of mitotic protein dynamics and function in Drosophila embryos by live cell imaging and quantitative modeling. Methods Mol Biol. 2014; 1136:3-30. PMID: 24633790.
      View in: PubMed
    10. Scholey JM. Cilium assembly: delivery of tubulin by kinesin-2-powered trains. Curr Biol. 2013 Nov 04; 23(21):R956-9. PMID: 24200322.
      View in: PubMed
    11. Wang H, Brust-Mascher I, Civelekoglu-Scholey G, Scholey JM. Patronin mediates a switch from kinesin-13-dependent poleward flux to anaphase B spindle elongation. J Cell Biol. 2013 Oct 14; 203(1):35-46. PMID: 24100293; PMCID: PMC3798244.
    12. Scholey JM. Kinesin-2: a family of heterotrimeric and homodimeric motors with diverse intracellular transport functions. Annu Rev Cell Dev Biol. 2013; 29:443-69. PMID: 23750925.
      View in: PubMed
    13. Scholey JM. Compare and contrast the reaction coordinate diagrams for chemical reactions and cytoskeletal force generators. Mol Biol Cell. 2013 Feb; 24(4):433-9. PMID: 23408787; PMCID: PMC3571866.
    14. Brust-Mascher I, Ou G, Scholey JM. Measuring rates of intraflagellar transport along Caenorhabditis elegans sensory cilia using fluorescence microscopy. Methods Enzymol. 2013; 524:285-304. PMID: 23498746.
      View in: PubMed
    15. Acar S, Carlson DB, Budamagunta MS, Yarov-Yarovoy V, Correia JJ, NiƱonuevo MR, Jia W, Tao L, Leary JA, Voss JC, Evans JE, Scholey JM. The bipolar assembly domain of the mitotic motor kinesin-5. Nat Commun. 2013; 4:1343. PMID: 23299893; PMCID: PMC3562449.
    16. Scholey JM. Kinesin-2 motors transport IFT-particles, dyneins and tubulin subunits to the tips of Caenorhabditis elegans sensory cilia: relevance to vision research? Vision Res. 2012 Dec 15; 75:44-52. PMID: 22772029; PMCID: PMC3488156.
    17. Brust-Mascher I, Scholey JM. Mitotic motors and chromosome segregation: the mechanism of anaphase B. Biochem Soc Trans. 2011 Oct; 39(5):1149-53. PMID: 21936780.
      View in: PubMed
    18. Hao L, Efimenko E, Swoboda P, Scholey JM. The retrograde IFT machinery of C. elegans cilia: two IFT dynein complexes? PLoS One. 2011; 6(6):e20995. PMID: 21695221; PMCID: PMC3112216.
    19. Hao L, Thein M, Brust-Mascher I, Civelekoglu-Scholey G, Lu Y, Acar S, Prevo B, Shaham S, Scholey JM. Intraflagellar transport delivers tubulin isotypes to sensory cilium middle and distal segments. Nat Cell Biol. 2011 Jun 05; 13(7):790-8. PMID: 21642982; PMCID: PMC3129367.
    20. de Lartigue J, Brust-Mascher I, Scholey JM. Anaphase B spindle dynamics in Drosophila S2 cells: Comparison with embryo spindles. Cell Div. 2011 Apr 08; 6(1):8. PMID: 21477279; PMCID: PMC3080273.
    21. Wang H, Brust-Mascher I, Cheerambathur D, Scholey JM. Coupling between microtubule sliding, plus-end growth and spindle length revealed by kinesin-8 depletion. Cytoskeleton (Hoboken). 2010 Nov; 67(11):715-28. PMID: 20814910; PMCID: PMC2998535.
    22. Pan X, Acar S, Scholey JM. Torque generation by one of the motor subunits of heterotrimeric kinesin-2. Biochem Biophys Res Commun. 2010 Oct 08; 401(1):53-7. PMID: 20833139; PMCID: PMC3787135.
    23. Civelekoglu-Scholey G, Scholey JM. Mitotic force generators and chromosome segregation. Cell Mol Life Sci. 2010 Jul; 67(13):2231-50. PMID: 20221784; PMCID: PMC2883081.
    24. Tao L, Scholey JM. Purification and assay of mitotic motors. Methods. 2010 Jun; 51(2):233-41. PMID: 20096785; PMCID: PMC3715878.
    25. Civelekoglu-Scholey G, Tao L, Brust-Mascher I, Wollman R, Scholey JM. Prometaphase spindle maintenance by an antagonistic motor-dependent force balance made robust by a disassembling lamin-B envelope. J Cell Biol. 2010 Jan 11; 188(1):49-68. PMID: 20065089; PMCID: PMC2812851.
    26. Goshima G, Scholey JM. Control of mitotic spindle length. Annu Rev Cell Dev Biol. 2010; 26:21-57. PMID: 20604709.
      View in: PubMed
    27. Peterman EJ, Scholey JM. Mitotic microtubule crosslinkers: insights from mechanistic studies. Curr Biol. 2009 Dec 15; 19(23):R1089-94. PMID: 20064413.
      View in: PubMed
    28. Hao L, Acar S, Evans J, Ou G, Scholey JM. Analysis of intraflagellar transport in C. elegans sensory cilia. Methods Cell Biol. 2009; 93:235-66. PMID: 20409821.
      View in: PubMed
    29. Brust-Mascher I, Scholey JM. Microinjection techniques for studying mitosis in the Drosophila melanogaster syncytial embryo. J Vis Exp. 2009 Sep 15; (31). PMID: 19755959; PMCID: PMC3150050.
    30. Scholey JM. Kinesin-5 in Drosophila embryo mitosis: sliding filament or spindle matrix mechanism? Cell Motil Cytoskeleton. 2009 Aug; 66(8):500-8. PMID: 19291760; PMCID: PMC2778298.
    31. Hao L, Scholey JM. Intraflagellar transport at a glance. J Cell Sci. 2009 Apr 01; 122(Pt 7):889-92. PMID: 19295122; PMCID: PMC2720924.
    32. Brust-Mascher I, Sommi P, Cheerambathur DK, Scholey JM. Kinesin-5-dependent poleward flux and spindle length control in Drosophila embryo mitosis. Mol Biol Cell. 2009 Mar; 20(6):1749-62. PMID: 19158379; PMCID: PMC2655252.
    33. van den Wildenberg SM, Tao L, Kapitein LC, Schmidt CF, Scholey JM, Peterman EJ. The homotetrameric kinesin-5 KLP61F preferentially crosslinks microtubules into antiparallel orientations. Curr Biol. 2008 Dec 09; 18(23):1860-4. PMID: 19062285; PMCID: PMC2657206.
    34. Cheerambathur DK, Brust-Mascher I, Civelekoglu-Scholey G, Scholey JM. Dynamic partitioning of mitotic kinesin-5 cross-linkers between microtubule-bound and freely diffusing states. J Cell Biol. 2008 Aug 11; 182(3):429-36. PMID: 18678711; PMCID: PMC2500124.
    35. Wollman R, Civelekoglu-Scholey G, Scholey JM, Mogilner A. Reverse engineering of force integration during mitosis in the Drosophila embryo. Mol Syst Biol. 2008; 4:195. PMID: 18463619; PMCID: PMC2424291.
    36. Scholey JM. Intraflagellar transport motors in cilia: moving along the cell's antenna. J Cell Biol. 2008 Jan 14; 180(1):23-9. PMID: 18180368; PMCID: PMC2213603.
    37. Civelekoglu-Scholey G, Scholey JM. Mitotic motors: kinesin-5 takes a brake. Curr Biol. 2007 Jul 17; 17(14):R544-7. PMID: 17637353.
      View in: PubMed
    38. Cheerambathur DK, Civelekoglu-Scholey G, Brust-Mascher I, Sommi P, Mogilner A, Scholey JM. Quantitative analysis of an anaphase B switch: predicted role for a microtubule catastrophe gradient. J Cell Biol. 2007 Jun 18; 177(6):995-1004. PMID: 17576796; PMCID: PMC2064360.
    39. Goshima G, Wollman R, Goodwin SS, Zhang N, Scholey JM, Vale RD, Stuurman N. Genes required for mitotic spindle assembly in Drosophila S2 cells. Science. 2007 Apr 20; 316(5823):417-21. PMID: 17412918; PMCID: PMC2837481.
    40. Inglis PN, Ou G, Leroux MR, Scholey JM. The sensory cilia of Caenorhabditis elegans. WormBook. 2007 Mar 08; 1-22. PMID: 18050505.
      View in: PubMed
    41. Ou G, Koga M, Blacque OE, Murayama T, Ohshima Y, Schafer JC, Li C, Yoder BK, Leroux MR, Scholey JM. Sensory ciliogenesis in Caenorhabditis elegans: assignment of IFT components into distinct modules based on transport and phenotypic profiles. Mol Biol Cell. 2007 May; 18(5):1554-69. PMID: 17314406; PMCID: PMC1855012.
    42. Brust-Mascher I, Scholey JM. Mitotic spindle dynamics in Drosophila. Int Rev Cytol. 2007; 259:139-72. PMID: 17425941.
      View in: PubMed
    43. Tao L, Mogilner A, Civelekoglu-Scholey G, Wollman R, Evans J, Stahlberg H, Scholey JM. A homotetrameric kinesin-5, KLP61F, bundles microtubules and antagonizes Ncd in motility assays. Curr Biol. 2006 Dec 05; 16(23):2293-302. PMID: 17141610.
      View in: PubMed
    44. Blacque OE, Li C, Inglis PN, Esmail MA, Ou G, Mah AK, Baillie DL, Scholey JM, Leroux MR. The WD repeat-containing protein IFTA-1 is required for retrograde intraflagellar transport. Mol Biol Cell. 2006 Dec; 17(12):5053-62. PMID: 17021254; PMCID: PMC1679672.
    45. Pan X, Ou G, Civelekoglu-Scholey G, Blacque OE, Endres NF, Tao L, Mogilner A, Leroux MR, Vale RD, Scholey JM. Mechanism of transport of IFT particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motors. J Cell Biol. 2006 Sep 25; 174(7):1035-45. PMID: 17000880; PMCID: PMC2064394.
    46. Efimenko E, Blacque OE, Ou G, Haycraft CJ, Yoder BK, Scholey JM, Leroux MR, Swoboda P. Caenorhabditis elegans DYF-2, an orthologue of human WDR19, is a component of the intraflagellar transport machinery in sensory cilia. Mol Biol Cell. 2006 Nov; 17(11):4801-11. PMID: 16957054; PMCID: PMC1635379.
    47. Scholey J. Q & A. Curr Biol. 2006 May 09; 16(9):R306-7. PMID: 16721934.
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    48. Scholey JM, Anderson KV. Intraflagellar transport and cilium-based signaling. Cell. 2006 May 05; 125(3):439-42. PMID: 16678091.
      View in: PubMed
    49. Evans JE, Snow JJ, Gunnarson AL, Ou G, Stahlberg H, McDonald KL, Scholey JM. Functional modulation of IFT kinesins extends the sensory repertoire of ciliated neurons in Caenorhabditis elegans. J Cell Biol. 2006 Feb 27; 172(5):663-9. PMID: 16492809; PMCID: PMC2063699.
    50. Mogilner A, Wollman R, Civelekoglu-Scholey G, Scholey J. Modeling mitosis. Trends Cell Biol. 2006 Feb; 16(2):88-96. PMID: 16406522.
      View in: PubMed
    51. Goshima G, Wollman R, Stuurman N, Scholey JM, Vale RD. Length control of the metaphase spindle. Curr Biol. 2005 Nov 22; 15(22):1979-88. PMID: 16303556.
      View in: PubMed
    52. Ou G, Blacque OE, Snow JJ, Leroux MR, Scholey JM. Functional coordination of intraflagellar transport motors. Nature. 2005 Jul 28; 436(7050):583-7. PMID: 16049494.
      View in: PubMed
    53. Morales-Mulia S, Scholey JM. Spindle pole organization in Drosophila S2 cells by dynein, abnormal spindle protein (Asp), and KLP10A. Mol Biol Cell. 2005 Jul; 16(7):3176-86. PMID: 15888542; PMCID: PMC1165402.
    54. Scholey JM, Ou G, Snow J, Gunnarson A. Intraflagellar transport motors in Caenorhabditis elegans neurons. Biochem Soc Trans. 2004 Nov; 32(Pt 5):682-4. PMID: 15493987.
      View in: PubMed
    55. Snow JJ, Ou G, Gunnarson AL, Walker MR, Zhou HM, Brust-Mascher I, Scholey JM. Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons. Nat Cell Biol. 2004 Nov; 6(11):1109-13. PMID: 15489852.
      View in: PubMed
    56. Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale RD, Walczak CE, Wordeman L. A standardized kinesin nomenclature. J Cell Biol. 2004 Oct 11; 167(1):19-22. PMID: 15479732; PMCID: PMC2041940.
    57. Kwon M, Scholey JM. Spindle mechanics and dynamics during mitosis in Drosophila. Trends Cell Biol. 2004 Apr; 14(4):194-205. PMID: 15066637.
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    58. Rogers GC, Rogers SL, Schwimmer TA, Ems-McClung SC, Walczak CE, Vale RD, Scholey JM, Sharp DJ. Two mitotic kinesins cooperate to drive sister chromatid separation during anaphase. Nature. 2004 Jan 22; 427(6972):364-70. PMID: 14681690.
      View in: PubMed
    59. Kwon M, Morales-Mulia S, Brust-Mascher I, Rogers GC, Sharp DJ, Scholey JM. The chromokinesin, KLP3A, dives mitotic spindle pole separation during prometaphase and anaphase and facilitates chromatid motility. Mol Biol Cell. 2004 Jan; 15(1):219-33. PMID: 14528012; PMCID: PMC307542.
    60. Scholey JM, Brust-Mascher I, Mogilner A. Cell division. Nature. 2003 Apr 17; 422(6933):746-52. PMID: 12700768.
      View in: PubMed
    61. Scholey JM. Intraflagellar transport. Annu Rev Cell Dev Biol. 2003; 19:423-43. PMID: 14570576.
      View in: PubMed
    62. Brust-Mascher I, Scholey JM. Microtubule flux and sliding in mitotic spindles of Drosophila embryos. Mol Biol Cell. 2002 Nov; 13(11):3967-75. PMID: 12429839; PMCID: PMC133607.
    63. Scholey JM. Rafting along the axon on Unc104 motors. Dev Cell. 2002 May; 2(5):515-6. PMID: 12015956.
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    64. Scholey JM, Rogers GC, Sharp DJ. Mitosis, microtubules, and the matrix. J Cell Biol. 2001 Jul 23; 154(2):261-6. PMID: 11470815; PMCID: PMC2150769.
    65. Scholey JM. Functions of motor proteins in echinoderm embryos: an argument in support of antibody inhibition experiments. Cell Motil Cytoskeleton. 1998; 39(4):257-60. PMID: 9556327.
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