-
H3K4me1 recruits DNA repair proteins in plants. Plant Cell. 2024 Mar 26.
Quiroz D, Oya S, Lopez-Mateos D, Zhao K, Pierce A, Ortega L, Ali A, Carbonell-Bejerano P, Yarov-Yarovoy V, Suzuki S, Hayashi G, Osakabe A, Monroe JG. PMID: 38531669.
View in:
PubMed Mentions: Fields:
Translation:
AnimalsCells
-
Structural modeling of ion channels using AlphaFold2, RoseTTAFold2, and ESMFold. Channels (Austin). 2024 12; 18(1):2325032.
Nguyen PT, Harris BJ, Mateos DL, González AH, Murray AM, Yarov-Yarovoy V. PMID: 38445990; PMCID: PMC10936637.
View in:
PubMed Mentions: Fields:
Translation:
Humans
-
Harnessing AlphaFold to reveal state secrets: Prediction of hERG closed and inactivated states. bioRxiv. 2024 Jan 30.
Ngo K, Yarov-Yarovoy V, Clancy CE, Vorobyov I. PMID: 38352360; PMCID: PMC10862728.
View in:
PubMed Mentions:
-
Elucidating molecular mechanisms of protoxin-II state-specific binding to the human NaV1.7 channel. J Gen Physiol. 2024 Feb 05; 156(2).
Ngo K, Lopez Mateos D, Han Y, Rouen KC, Ahn SH, Wulff H, Clancy CE, Yarov-Yarovoy V, Vorobyov I. PMID: 38127314; PMCID: PMC10737443.
View in:
PubMed Mentions: Fields:
Translation:
HumansCells
-
Toward Digital Twin Technology for Precision Pharmacology. JACC Clin Electrophysiol. 2024 Feb; 10(2):359-364.
Yang PC, Jeng MT, Yarov-Yarovoy V, Santana LF, Vorobyov I, Clancy CE. PMID: 38069976.
View in:
PubMed Mentions: Fields:
Translation:
HumansCells
-
Structural modeling of hERG channel-drug interactions using Rosetta. Front Pharmacol. 2023; 14:1244166.
Emigh Cortez AM, DeMarco KR, Furutani K, Bekker S, Sack JT, Wulff H, Clancy CE, Vorobyov I, Yarov-Yarovoy V. PMID: 38035013; PMCID: PMC10682396.
View in:
PubMed Mentions:
1
-
A Novel Peptide Prevents Enterotoxin- and Inflammation-Induced Intestinal Fluid Secretion by Stimulating Sodium-Hydrogen Exchanger 3 Activity. Gastroenterology. 2023 10; 165(4):986-998.e11.
Zachos NC, Vaughan H, Sarker R, Est-Witte S, Chakraborty M, Baetz NW, Yu H, Yarov-Yarovoy V, McNamara G, Green JJ, Tse CM, Donowitz M. PMID: 37429363.
View in:
PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
-
Elucidating Molecular Mechanisms of Protoxin-2 State-specific Binding to the Human NaV1.7 Channel. bioRxiv. 2023 Jun 15.
Ngo K, Mateos DL, Han Y, Rouen KC, Ahn SH, Wulff H, Clancy CE, Yarov-Yarovoy V, Vorobyov I. PMID: 36909474; PMCID: PMC10002706.
View in:
PubMed Mentions:
-
Opening of capsaicin receptor TRPV1 is stabilized equally by its four subunits. J Biol Chem. 2023 06; 299(6):104828.
Li S, Nguyen PT, Vu S, Yarov-Yarovoy V, Zheng J. PMID: 37196769; PMCID: PMC10318505.
View in:
PubMed Mentions:
2 Fields:
Translation:
Animals
-
Energetic landscape of polycystin channel gating. EMBO Rep. 2023 Jul 05; 24(7):e56783.
Ng LC, Harris BJ, Larmore M, Ta MC, Vien TN, Tokars VL, Yarov-Yarovoy V, DeCaen PG. PMID: 37158562; PMCID: PMC10328073.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
-
Molecular determinants of μ-conotoxin KIIIA interaction with the human voltage-gated sodium channel NaV1.7. Front Pharmacol. 2023; 14:1156855.
Kimball IH, Nguyen PT, Olivera BM, Sack JT, Yarov-Yarovoy V. PMID: 37007002; PMCID: PMC10060530.
View in:
PubMed Mentions:
1
-
Elucidation of a dynamic interplay between a beta-2 adrenergic receptor, its agonist, and stimulatory G protein. Proc Natl Acad Sci U S A. 2023 03 07; 120(10):e2215916120.
Han Y, Dawson JRD, DeMarco KR, Rouen KC, Bekker S, Yarov-Yarovoy V, Clancy CE, Xiang YK, Vorobyov I. PMID: 36853938; PMCID: PMC10013855.
View in:
PubMed Mentions:
2 Fields:
Translation:
Cells
-
Structural modeling of peptide toxin-ion channel interactions using RosettaDock. Proteins. 2023 07; 91(7):872-889.
Mateos DL, Yarov-Yarovoy V. PMID: 36729043.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
-
TRPV1 Opening is Stabilized Equally by Its Four Subunits. bioRxiv. 2023 Jan 27.
Li S, Nguyen PT, Vu S, Yarov-Yarovoy V, Zheng J. PMID: 36747729; PMCID: PMC9900918.
View in:
PubMed Mentions:
-
Computational design of peptides to target NaV1.7 channel with high potency and selectivity for the treatment of pain. Elife. 2022 12 28; 11.
Nguyen PT, Nguyen HM, Wagner KM, Stewart RG, Singh V, Thapa P, Chen YJ, Lillya MW, Ton AT, Kondo R, Ghetti A, Pennington MW, Hammock B, Griffith TN, Sack JT, Wulff H, Yarov-Yarovoy V. PMID: 36576241; PMCID: PMC9831606.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
-
Single amino acid residue mediates reciprocal specificity in two mosquito odorant receptors. Elife. 2022 Dec 13; 11.
Franco FP, Xu P, Harris BJ, Yarov-Yarovoy V, Leal WS. PMID: 36511779.
View in:
PubMed Mentions:
1 Fields:
Translation:
Animals
-
Adenylyl cyclase isoform 1 contributes to sinoatrial node automaticity via functional microdomains. JCI Insight. 2022 11 22; 7(22).
Ren L, Thai PN, Gopireddy RR, Timofeyev V, Ledford HA, Woltz RL, Park S, Puglisi JL, Moreno CM, Santana LF, Conti AC, Kotlikoff MI, Xiang YK, Yarov-Yarovoy V, Zaccolo M, Zhang XD, Yamoah EN, Navedo MF, Chiamvimonvat N. PMID: 36509290; PMCID: PMC9746826.
View in:
PubMed Mentions:
3 Fields:
Translation:
Animals
-
Structural modeling of the hERG potassium channel and associated drug interactions. Front Pharmacol. 2022; 13:966463.
Maly J, Emigh AM, DeMarco KR, Furutani K, Sack JT, Clancy CE, Vorobyov I, Yarov-Yarovoy V. PMID: 36188564; PMCID: PMC9523588.
View in:
PubMed Mentions:
7
-
Common Structural Pattern for Flecainide Binding in Atrial-Selective Kv1.5 and Nav1.5 Channels: A Computational Approach. Pharmaceutics. 2022 Jun 27; 14(7).
Mazola Y, Márquez Montesinos JCE, Ramírez D, Zúñiga L, Decher N, Ravens U, Yarov-Yarovoy V, González W. PMID: 35890252; PMCID: PMC9318806.
View in:
PubMed Mentions:
2
-
Structural and Functional Characterization of a Novel Scorpion Toxin that Inhibits NaV1.8 via Interactions With the DI Voltage Sensor and DII Pore Module. Front Pharmacol. 2022; 13:846992.
George K, Lopez-Mateos D, Abd El-Aziz TM, Xiao Y, Kline J, Bao H, Raza S, Stockand JD, Cummins TR, Fornelli L, Rowe MP, Yarov-Yarovoy V, Rowe AH. PMID: 35662692; PMCID: PMC9160825.
View in:
PubMed Mentions:
-
Structural insights into TRPV2 activation by small molecules. Nat Commun. 2022 04 28; 13(1):2334.
Pumroy RA, Protopopova AD, Fricke TC, Lange IU, Haug FM, Nguyen PT, Gallo PN, Sousa BB, Bernardes GJL, Yarov-Yarovoy V, Leffler A, Moiseenkova-Bell VY. PMID: 35484159; PMCID: PMC9051106.
View in:
PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
-
Towards Structure-Guided Development of Pain Therapeutics Targeting Voltage-Gated Sodium Channels. Front Pharmacol. 2022; 13:842032.
Nguyen PT, Yarov-Yarovoy V. PMID: 35153801; PMCID: PMC8830516.
View in:
PubMed Mentions:
9
-
Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks. Nat Commun. 2021 11 29; 12(1):6947.
Koehler Leman J, Lyskov S, Lewis SM, Adolf-Bryfogle J, Alford RF, Barlow K, Ben-Aharon Z, Farrell D, Fell J, Hansen WA, Harmalkar A, Jeliazkov J, Kuenze G, Krys JD, Ljubetic A, Loshbaugh AL, Maguire J, Moretti R, Mulligan VK, Nance ML, Nguyen PT, Ó Conchúir S, Roy Burman SS, Samanta R, Smith ST, Teets F, Tiemann JKS, Watkins A, Woods H, Yachnin BJ, Bahl CD, Bailey-Kellogg C, Baker D, Das R, DiMaio F, Khare SD, Kortemme T, Labonte JW, Lindorff-Larsen K, Meiler J, Schief W, Schueler-Furman O, Siegel JB, Stein A, Yarov-Yarovoy V, Kuhlman B, Leaver-Fay A, Gront D, Gray JJ, Bonneau R. PMID: 34845212; PMCID: PMC8630030.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
-
Disruption of protein quality control of the human ether-à-go-go related gene K+ channel results in profound long QT syndrome. Heart Rhythm. 2022 02; 19(2):281-292.
Ledford HA, Ren L, Thai PN, Park S, Timofeyev V, Sirish P, Xu W, Emigh AM, Priest JR, Perez MV, Ashley EA, Yarov-Yarovoy V, Yamoah EN, Zhang XD, Chiamvimonvat N. PMID: 34634443; PMCID: PMC8810706.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
-
De Novo Design of Peptidic Positive Allosteric Modulators Targeting TRPV1 with Analgesic Effects. Adv Sci (Weinh). 2021 09; 8(17):e2101716.
Xu L, Zhang H, Wang Y, Lu X, Zhao Z, Ma C, Yang S, Yarov-Yarovoy V, Tian Y, Zheng J, Yang F. PMID: 34247451; PMCID: PMC8425881.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
-
Molecular determinants of pro-arrhythmia proclivity of d- and l-sotalol via a multi-scale modeling pipeline. J Mol Cell Cardiol. 2021 09; 158:163-177.
DeMarco KR, Yang PC, Singh V, Furutani K, Dawson JRD, Jeng MT, Fettinger JC, Bekker S, Ngo VA, Noskov SY, Yarov-Yarovoy V, Sack JT, Wulff H, Clancy CE, Vorobyov I. PMID: 34062207; PMCID: PMC8906354.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
-
Toggle switch residues control allosteric transitions in bacterial adhesins by participating in a concerted repacking of the protein core. PLoS Pathog. 2021 04; 17(4):e1009440.
Kisiela DI, Magala P, Interlandi G, Carlucci LA, Ramos A, Tchesnokova V, Basanta B, Yarov-Yarovoy V, Avagyan H, Hovhannisyan A, Thomas WE, Stenkamp RE, Klevit RE, Sokurenko EV. PMID: 33826682; PMCID: PMC8064603.
View in:
PubMed Mentions:
6 Fields:
Translation:
Cells
-
Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning. Cell. 2020 12 23; 183(7):1986-2002.e26.
Unger EK, Keller JP, Altermatt M, Liang R, Matsui A, Dong C, Hon OJ, Yao Z, Sun J, Banala S, Flanigan ME, Jaffe DA, Hartanto S, Carlen J, Mizuno GO, Borden PM, Shivange AV, Cameron LP, Sinning S, Underhill SM, Olson DE, Amara SG, Temple Lang D, Rudnick G, Marvin JS, Lavis LD, Lester HA, Alvarez VA, Fisher AJ, Prescher JA, Kash TL, Yarov-Yarovoy V, Gradinaru V, Looger LL, Tian L. PMID: 33333022; PMCID: PMC8025677.
View in:
PubMed Mentions:
61 Fields:
Translation:
HumansAnimalsCells
-
Different arrhythmia-associated calmodulin mutations have distinct effects on cardiac SK channel regulation. J Gen Physiol. 2020 12 07; 152(12).
Ledford HA, Park S, Muir D, Woltz RL, Ren L, Nguyen PT, Sirish P, Wang W, Sihn CR, George AL, Knollmann BC, Yamoah EN, Yarov-Yarovoy V, Zhang XD, Chiamvimonvat N. PMID: 33211795; PMCID: PMC7681919.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansCells
-
New capsaicin analogs as molecular rulers to define the permissive conformation of the mouse TRPV1 ligand-binding pocket. Elife. 2020 11 09; 9.
Vu S, Singh V, Wulff H, Yarov-Yarovoy V, Zheng J. PMID: 33164749; PMCID: PMC7671684.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
-
An Unorthodox Mechanism Underlying Voltage Sensitivity of TRPV1 Ion Channel. Adv Sci (Weinh). 2020 Oct; 7(20):2000575.
Yang F, Xu L, Lee BH, Xiao X, Yarov-Yarovoy V, Zheng J. PMID: 33101845; PMCID: PMC7578911.
View in:
PubMed Mentions:
14 Fields:
-
α-Actinin-1 promotes activity of the L-type Ca2+ channel Cav1.2. EMBO J. 2020 Sep 15; 39(18):e106171.
Turner M, Anderson DE, Bartels P, Nieves-Cintron M, Coleman AM, Henderson PB, Man KNM, Tseng PY, Yarov-Yarovoy V, Bers DM, Navedo MF, Horne MC, Ames JB, Hell JW. PMID: 33433005; PMCID: PMC7507692.
View in:
PubMed Mentions:
2 Fields:
-
Gating Properties of Mutant Sodium Channels and Responses to Sodium Current Inhibitors Predict Mexiletine-Sensitive Mutations of Long QT Syndrome 3. Front Pharmacol. 2020; 11:1182.
Li G, Woltz RL, Wang CY, Ren L, He PX, Yu SD, Liu XQ, Yarov-Yarovoy V, Hu D, Chiamvimonvat N, Wu L. PMID: 32848785; PMCID: PMC7417866.
View in:
PubMed Mentions:
5
-
Distinguishing Potassium Channel Resting State Conformations in Live Cells with Environment-Sensitive Fluorescence. ACS Chem Neurosci. 2020 08 05; 11(15):2316-2326.
Fletcher-Taylor S, Thapa P, Sepela RJ, Kaakati R, Yarov-Yarovoy V, Sack JT, Cohen BE. PMID: 32579336; PMCID: PMC7894042.
View in:
PubMed Mentions:
4 Fields:
Translation:
Cells
-
Cooperativity of Kv7.4 channels confers ultrafast electromechanical sensitivity and emergent properties in cochlear outer hair cells. Sci Adv. 2020 04; 6(15):eaba1104.
Perez-Flores MC, Lee JH, Park S, Zhang XD, Sihn CR, Ledford HA, Wang W, Kim HJ, Timofeyev V, Yarov-Yarovoy V, Chiamvimonvat N, Rabbitt RD, Yamoah EN. PMID: 32285007; PMCID: PMC7141818.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
-
The MX-Helix of Muscle nAChR Subunits Regulates Receptor Assembly and Surface Trafficking. Front Mol Neurosci. 2020; 13:48.
Rudell JC, Borges LS, Yarov-Yarovoy V, Ferns M. PMID: 32265653; PMCID: PMC7105636.
View in:
PubMed Mentions:
4
-
A Computational Pipeline to Predict Cardiotoxicity: From the Atom to the Rhythm. Circ Res. 2020 04 10; 126(8):947-964.
Yang PC, DeMarco KR, Aghasafari P, Jeng MT, Dawson JRD, Bekker S, Noskov SY, Yarov-Yarovoy V, Vorobyov I, Clancy CE. PMID: 32091972; PMCID: PMC7155920.
View in:
PubMed Mentions:
31 Fields:
Translation:
HumansCells
-
α-Actinin-1 promotes activity of the L-type Ca2+ channel Cav 1.2. EMBO J. 2020 03 02; 39(5):e102622.
Turner M, Anderson DE, Bartels P, Nieves-Cintron M, Coleman AM, Henderson PB, Man KNM, Tseng PY, Yarov-Yarovoy V, Bers DM, Navedo MF, Horne MC, Ames JB, Hell JW. PMID: 31985069; PMCID: PMC7049811.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansCells
-
Veratridine: A Janus-Faced Modulator of Voltage-Gated Sodium Ion Channels. ACS Chem Neurosci. 2020 02 05; 11(3):418-426.
Craig RA, Garrison CE, Nguyen PT, Yarov-Yarovoy V, Du Bois J. PMID: 31951114.
View in:
PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
-
The Trials and Tribulations of Structure Assisted Design of KCa Channel Activators. Front Pharmacol. 2019; 10:972.
Shim H, Brown BM, Singh L, Singh V, Fettinger JC, Yarov-Yarovoy V, Wulff H. PMID: 31616290; PMCID: PMC6764326.
View in:
PubMed Mentions:
12
-
The Sodium Channel Voltage Sensor Slides to Rest. Trends Pharmacol Sci. 2019 10; 40(10):718-720.
Yarov-Yarovoy V, DeCaen P. PMID: 31495454; PMCID: PMC7373202.
View in:
PubMed Mentions:
1 Fields:
Translation:
Cells
-
Pathogenic effects of agrin V1727F mutation are isoform specific and decrease its expression and affinity for HSPGs and LRP4. Hum Mol Genet. 2019 08 15; 28(16):2648-2658.
Rudell JB, Maselli RA, Yarov-Yarovoy V, Ferns MJ. PMID: 30994901; PMCID: PMC6687949.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansCells
-
Structural mechanisms underlying activation of TRPV1 channels by pungent compounds in gingers. Br J Pharmacol. 2019 Sep; 176(17):3364-3377.
Yin Y, Dong Y, Vu S, Yang F, Yarov-Yarovoy V, Tian Y, Zheng J. PMID: 31207668; PMCID: PMC6692589.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
-
Opening TRPP2 (PKD2L1) requires the transfer of gating charges. Proc Natl Acad Sci U S A. 2019 07 30; 116(31):15540-15549.
Ng LCT, Vien TN, Yarov-Yarovoy V, DeCaen PG. PMID: 31315976; PMCID: PMC6681712.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansCells
-
A distinct structural mechanism underlies TRPV1 activation by piperine. Biochem Biophys Res Commun. 2019 08 20; 516(2):365-372.
Dong Y, Yin Y, Vu S, Yang F, Yarov-Yarovoy V, Tian Y, Zheng J. PMID: 31213294; PMCID: PMC6626684.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
-
Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 05; 18(5):339-357.
Wulff H, Christophersen P, Colussi P, Chandy KG, Yarov-Yarovoy V. PMID: 30728472; PMCID: PMC6499689.
View in:
PubMed Mentions:
63 Fields:
Translation:
HumansAnimals
-
Sensitivity to the two peptide bacteriocin plantaricin EF is dependent on CorC, a membrane-bound, magnesium/cobalt efflux protein. Microbiologyopen. 2019 11; 8(11):e827.
Heeney DD, Yarov-Yarovoy V, Marco ML. PMID: 30891921; PMCID: PMC6854853.
View in:
PubMed Mentions:
12 Fields:
Translation:
Cells
-
Editorial. Neurosci Lett. 2019 05 01; 700:1-2.
Noskov SY, Yarov-Yarovoy V. PMID: 30822438.
View in:
PubMed Mentions: Fields:
Translation:
Cells
-
Structural basis for antiarrhythmic drug interactions with the human cardiac sodium channel. Proc Natl Acad Sci U S A. 2019 02 19; 116(8):2945-2954.
Nguyen PT, DeMarco KR, Vorobyov I, Clancy CE, Yarov-Yarovoy V. PMID: 30728299; PMCID: PMC6386684.
View in:
PubMed Mentions:
38 Fields:
Translation:
HumansCells
-
The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel. Nat Commun. 2018 07 23; 9(1):2879.
Yang F, Xiao X, Lee BH, Vu S, Yang W, Yarov-Yarovoy V, Zheng J. PMID: 30038260; PMCID: PMC6056546.
View in:
PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
-
Structural Determinants for the Selectivity of the Positive KCa3.1 Gating Modulator 5-Methylnaphtho[2,1-d]oxazol-2-amine (SKA-121). Mol Pharmacol. 2017 10; 92(4):469-480.
Brown BM, Shim H, Zhang M, Yarov-Yarovoy V, Wulff H. PMID: 28760780; PMCID: PMC5588545.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
-
A novel tarantula toxin stabilizes the deactivated voltage sensor of bacterial sodium channel. FASEB J. 2017 07; 31(7):3167-3178.
Tang C, Zhou X, Nguyen PT, Zhang Y, Hu Z, Zhang C, Yarov-Yarovoy V, DeCaen PG, Liang S, Liu Z. PMID: 28400471.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
-
Gain-of-function mutation of a voltage-gated sodium channel NaV1.7 associated with peripheral pain and impaired limb development. J Biol Chem. 2017 06 02; 292(22):9262-9272.
Tanaka BS, Nguyen PT, Zhou EY, Yang Y, Yarov-Yarovoy V, Dib-Hajj SD, Waxman SG. PMID: 28381558; PMCID: PMC5454107.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCells
-
In vivo optophysiology reveals that G-protein activation triggers osmotic swelling and increased light scattering of rod photoreceptors. Proc Natl Acad Sci U S A. 2017 04 04; 114(14):E2937-E2946.
Zhang P, Zawadzki RJ, Goswami M, Nguyen PT, Yarov-Yarovoy V, Burns ME, Pugh EN. PMID: 28320964; PMCID: PMC5389324.
View in:
PubMed Mentions:
74 Fields:
Translation:
AnimalsCells
-
Structural Insights into the Atomistic Mechanisms of Action of Small Molecule Inhibitors Targeting the KCa3.1 Channel Pore. Mol Pharmacol. 2017 04; 91(4):392-402.
Nguyen HM, Singh V, Pressly B, Jenkins DP, Wulff H, Yarov-Yarovoy V. PMID: 28126850; PMCID: PMC5363711.
View in:
PubMed Mentions:
22 Fields:
Translation:
HumansCells
-
Potassium channels in the heart: structure, function and regulation. J Physiol. 2017 04 01; 595(7):2209-2228.
Grandi E, Sanguinetti MC, Bartos DC, Bers DM, Chen-Izu Y, Chiamvimonvat N, Colecraft HM, Delisle BP, Heijman J, Navedo MF, Noskov S, Proenza C, Vandenberg JI, Yarov-Yarovoy V. PMID: 27861921; PMCID: PMC5374109.
View in:
PubMed Mentions:
42 Fields:
Translation:
HumansAnimals
-
Activity-Dependent Palmitoylation Controls SynDIG1 Stability, Localization, and Function. J Neurosci. 2016 07 20; 36(29):7562-8.
Kaur I, Yarov-Yarovoy V, Kirk LM, Plambeck KE, Barragan EV, Ontiveros ES, Díaz E. PMID: 27445135; PMCID: PMC4951570.
View in:
PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
-
A Large and Phylogenetically Diverse Class of Type 1 Opsins Lacking a Canonical Retinal Binding Site. PLoS One. 2016; 11(6):e0156543.
Becker EA, Yao AI, Seitzer PM, Kind T, Wang T, Eigenheer R, Shao KS, Yarov-Yarovoy V, Facciotti MT. PMID: 27327432; PMCID: PMC4915679.
View in:
PubMed Mentions:
6 Fields:
Translation:
Cells
-
Rational design and validation of a vanilloid-sensitive TRPV2 ion channel. Proc Natl Acad Sci U S A. 2016 06 28; 113(26):E3657-66.
Yang F, Vu S, Yarov-Yarovoy V, Zheng J. PMID: 27298359; PMCID: PMC4932969.
View in:
PubMed Mentions:
33 Fields:
Translation:
HumansCells
-
Molecular Interactions in the Voltage Sensor Controlling Gating Properties of CaV Calcium Channels. Structure. 2016 Feb 02; 24(2):261-71.
Tuluc P, Yarov-Yarovoy V, Benedetti B, Flucher BE. PMID: 26749449; PMCID: PMC7360434.
View in:
PubMed Mentions:
24 Fields:
Translation:
Cells
-
Mechanisms of Calmodulin Regulation of Different Isoforms of Kv7.4 K+ Channels. J Biol Chem. 2016 Jan 29; 291(5):2499-509.
Sihn CR, Kim HJ, Woltz RL, Yarov-Yarovoy V, Yang PC, Xu J, Clancy CE, Zhang XD, Chiamvimonvat N, Yamoah EN. PMID: 26515070; PMCID: PMC4732230.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
-
A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1. Nat Commun. 2015 Sep 30; 6:8297.
Yang S, Yang F, Wei N, Hong J, Li B, Luo L, Rong M, Yarov-Yarovoy V, Zheng J, Wang K, Lai R. PMID: 26420335; PMCID: PMC4589873.
View in:
PubMed Mentions:
61 Fields:
Translation:
HumansAnimalsCells
-
Characterization of an Additional Splice Acceptor Site Introduced into CYP4B1 in Hominoidae during Evolution. PLoS One. 2015; 10(9):e0137110.
Schmidt EM, Wiek C, Parkinson OT, Roellecke K, Freund M, Gombert M, Lottmann N, Steward CA, Kramm CM, Yarov-Yarovoy V, Rettie AE, Hanenberg H. PMID: 26355749; PMCID: PMC4565547.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
-
A Polybasic Plasma Membrane Binding Motif in the I-II Linker Stabilizes Voltage-gated CaV1.2 Calcium Channel Function. J Biol Chem. 2015 Aug 21; 290(34):21086-21100.
Kaur G, Pinggera A, Ortner NJ, Lieb A, Sinnegger-Brauns MJ, Yarov-Yarovoy V, Obermair GJ, Flucher BE, Striessnig J. PMID: 26100638; PMCID: PMC4543666.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansCells
-
Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel. Nat Chem Biol. 2015 Jul; 11(7):518-524.
Yang F, Xiao X, Cheng W, Yang W, Yu P, Song Z, Yarov-Yarovoy V, Zheng J. PMID: 26053297; PMCID: PMC4472570.
View in:
PubMed Mentions:
122 Fields:
Translation:
HumansAnimalsCells
-
Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels. Elife. 2015 May 07; 4:e06774.
Gupta K, Zamanian M, Bae C, Milescu M, Krepkiy D, Tilley DC, Sack JT, Yarov-Yarovoy V, Kim JI, Swartz KJ. PMID: 25948544; PMCID: PMC4423116.
View in:
PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
-
Na+ channel function, regulation, structure, trafficking and sequestration. J Physiol. 2015 Mar 15; 593(6):1347-60.
Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM. PMID: 25772290; PMCID: PMC4376415.
View in:
PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
-
Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol. Biochem J. 2015 Jan 01; 465(1):103-14.
Wiek C, Schmidt EM, Roellecke K, Freund M, Nakano M, Kelly EJ, Kaisers W, Yarov-Yarovoy V, Kramm CM, Rettie AE, Hanenberg H. PMID: 25247810; PMCID: PMC4312185.
View in:
PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
-
Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cells. Proc Natl Acad Sci U S A. 2014 Nov 04; 111(44):E4789-96.
Tilley DC, Eum KS, Fletcher-Taylor S, Austin DC, Dupré C, Patrón LA, Garcia RL, Lam K, Yarov-Yarovoy V, Cohen BE, Sack JT. PMID: 25331865; PMCID: PMC4226076.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
-
Local anesthetic and antiepileptic drug access and binding to a bacterial voltage-gated sodium channel. Proc Natl Acad Sci U S A. 2014 Sep 09; 111(36):13057-62.
Boiteux C, Vorobyov I, French RJ, French C, Yarov-Yarovoy V, Allen TW. PMID: 25136136; PMCID: PMC4246943.
View in:
PubMed Mentions:
49 Fields:
Translation:
Cells
-
Computational Models for Predictive Cardiac Ion Channel Pharmacology. Drug Discov Today Dis Models. 2014; 14:3-10.
Yarov-Yarovoy V, Allen TW, Clancy CE. PMID: 26635886; PMCID: PMC4665638.
View in:
PubMed Mentions:
7
-
Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca2+-activated K+ (SK2) channel. Proc Natl Acad Sci U S A. 2014 Jul 08; 111(27):9989-94.
Rafizadeh S, Zhang Z, Woltz RL, Kim HJ, Myers RE, Lu L, Tuteja D, Singapuri A, Bigdeli AA, Harchache SB, Knowlton AA, Yarov-Yarovoy V, Yamoah EN, Chiamvimonvat N. PMID: 24951510; PMCID: PMC4103345.
View in:
PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
-
Channels: Sticking to nooks and crannies. Nat Chem Biol. 2013 Aug; 9(8):473-4.
Wulff H, Yarov-Yarovoy V. PMID: 23868316.
View in:
PubMed Mentions:
3 Fields:
-
Adenylyl cyclase subtype-specific compartmentalization: differential regulation of L-type Ca2+ current in ventricular myocytes. Circ Res. 2013 Jun 07; 112(12):1567-76.
Timofeyev V, Myers RE, Kim HJ, Woltz RL, Sirish P, Heiserman JP, Li N, Singapuri A, Tang T, Yarov-Yarovoy V, Yamoah EN, Hammond HK, Chiamvimonvat N. PMID: 23609114; PMCID: PMC3751398.
View in:
PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
-
The bipolar assembly domain of the mitotic motor kinesin-5. Nat Commun. 2013; 4:1343.
Acar S, Carlson DB, Budamagunta MS, Yarov-Yarovoy V, Correia JJ, Niñonuevo MR, Jia W, Tao L, Leary JA, Voss JC, Evans JE, Scholey JM. PMID: 23299893; PMCID: PMC3562449.
View in:
PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
-
First insights into structure-function relationships of alkylglycerol monooxygenase. Pteridines. 2013 Jan 1; 24(1):99-103.
Watschinger WK, Fuchs FJ, Yarov-Yarovoy YV, Keller KM, Golderer GG, Hermetter HA, Werner-Felmayer WG, Hulo HN, Werner WE. .
View in:
Publisher Site Mentions:
-
An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations. J Gen Physiol. 2012 Dec; 140(6):587-94.
Vargas E, Yarov-Yarovoy V, Khalili-Araghi F, Catterall WA, Klein ML, Tarek M, Lindahl E, Schulten K, Perozo E, Bezanilla F, Roux B. PMID: 23183694; PMCID: PMC3514734.
View in:
PubMed Mentions:
111 Fields:
Translation:
Cells
-
Na⁺/K⁺-ATPase E960 and phospholemman F28 are critical for their functional interaction. Proc Natl Acad Sci U S A. 2012 Dec 11; 109(50):20756-61.
Khafaga M, Bossuyt J, Mamikonian L, Li JC, Lee LL, Yarov-Yarovoy V, Despa S, Bers DM. PMID: 23185013; PMCID: PMC3528502.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
-
Mapping the interaction site for a β-scorpion toxin in the pore module of domain III of voltage-gated Na(+) channels. J Biol Chem. 2012 Aug 31; 287(36):30719-28.
Zhang JZ, Yarov-Yarovoy V, Scheuer T, Karbat I, Cohen L, Gordon D, Gurevitz M, Catterall WA. PMID: 22761417; PMCID: PMC3436316.
View in:
PubMed Mentions:
36 Fields:
Translation:
AnimalsCells
-
Catalytic residues and a predicted structure of tetrahydrobiopterin-dependent alkylglycerol mono-oxygenase. Biochem J. 2012 Apr 01; 443(1):279-86.
Watschinger K, Fuchs JE, Yarov-Yarovoy V, Keller MA, Golderer G, Hermetter A, Werner-Felmayer G, Hulo N, Werner ER. PMID: 22220568; PMCID: PMC3304488.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
-
Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations. J Gen Physiol. 2012 Apr; 139(4):273-83.
Cui Y, Yang F, Cao X, Yarov-Yarovoy V, Wang K, Zheng J. PMID: 22412190; PMCID: PMC3315147.
View in:
PubMed Mentions:
65 Fields:
Translation:
HumansAnimalsCells
-
LG2 agrin mutation causing severe congenital myasthenic syndrome mimics functional characteristics of non-neural (z-) agrin. Hum Genet. 2012 Jul; 131(7):1123-35.
Maselli RA, Fernandez JM, Arredondo J, Navarro C, Ngo M, Beeson D, Cagney O, Williams DC, Wollmann RL, Yarov-Yarovoy V, Ferns MJ. PMID: 22205389; PMCID: PMC4795461.
View in:
PubMed Mentions:
44 Fields:
Translation:
HumansCells
-
Structural basis for gating charge movement in the voltage sensor of a sodium channel. Proc Natl Acad Sci U S A. 2012 Jan 10; 109(2):E93-102.
Yarov-Yarovoy V, DeCaen PG, Westenbroek RE, Pan CY, Scheuer T, Baker D, Catterall WA. PMID: 22160714; PMCID: PMC3258622.
View in:
PubMed Mentions:
159 Fields:
Translation:
Cells
-
Constitutive coupling of a naturally occurring human alpha1a-adrenergic receptor genetic variant to EGFR transactivation pathway. Proc Natl Acad Sci U S A. 2011 Dec 06; 108(49):19796-801.
Oganesian A, Yarov-Yarovoy V, Parks WC, Schwinn DA. PMID: 22089237; PMCID: PMC3241756.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
-
Gating charge interactions with the S1 segment during activation of a Na+ channel voltage sensor. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18825-30.
DeCaen PG, Yarov-Yarovoy V, Scheuer T, Catterall WA. PMID: 22042870; PMCID: PMC3219111.
View in:
PubMed Mentions:
53 Fields:
Translation:
HumansCells
-
Mapping the receptor site for alpha-scorpion toxins on a Na+ channel voltage sensor. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15426-31.
Wang J, Yarov-Yarovoy V, Kahn R, Gordon D, Gurevitz M, Scheuer T, Catterall WA. PMID: 21876146; PMCID: PMC3174582.
View in:
PubMed Mentions:
66 Fields:
Translation:
Cells
-
Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment. Structure. 2011 Aug 10; 19(8):1108-26.
Kufareva I, Rueda M, Katritch V, Stevens RC, Abagyan R, GPCR Dock 2010 participants. PMID: 21827947; PMCID: PMC3154726.
View in:
PubMed Mentions:
115 Fields:
Translation:
HumansCells
-
Structure-function map of the receptor site for β-scorpion toxins in domain II of voltage-gated sodium channels. J Biol Chem. 2011 Sep 23; 286(38):33641-51.
Zhang JZ, Yarov-Yarovoy V, Scheuer T, Karbat I, Cohen L, Gordon D, Gurevitz M, Catterall WA. PMID: 21795675; PMCID: PMC3190924.
View in:
PubMed Mentions:
40 Fields:
Translation:
AnimalsCells
-
Allosteric catch bond properties of the FimH adhesin from Salmonella enterica serovar Typhimurium. J Biol Chem. 2011 Nov 04; 286(44):38136-38147.
Kisiela DI, Kramer JJ, Tchesnokova V, Aprikian P, Yarov-Yarovoy V, Clegg S, Sokurenko EV. PMID: 21795699; PMCID: PMC3207454.
View in:
PubMed Mentions:
17 Fields:
Translation:
Cells
-
Finding homes for orphan cytochrome P450s: CYP4V2 and CYP4F22 in disease states. Mol Interv. 2011 Apr; 11(2):124-32.
Kelly EJ, Nakano M, Rohatgi P, Yarov-Yarovoy V, Rettie AE. PMID: 21540472; PMCID: PMC3109859.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansAnimals
-
Structural refinement of the hERG1 pore and voltage-sensing domains with ROSETTA-membrane and molecular dynamics simulations. Proteins. 2010 Nov 01; 78(14):2922-34.
Subbotina J, Yarov-Yarovoy V, Lees-Miller J, Durdagi S, Guo J, Duff HJ, Noskov SY. PMID: 20740484; PMCID: PMC2939218.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansCells
-
Calculation of the gating charge for the Kv1.2 voltage-activated potassium channel. Biophys J. 2010 May 19; 98(10):2189-98.
Khalili-Araghi F, Jogini V, Yarov-Yarovoy V, Tajkhorshid E, Roux B, Schulten K. PMID: 20483327; PMCID: PMC2872222.
View in:
PubMed Mentions:
94 Fields:
Translation:
AnimalsCells
-
Helical motion of an S4 voltage sensor revealed by gating pore currents. Channels (Austin). 2010 Mar-Apr; 4(2):75-7.
Catterall WA, Yarov-Yarovoy V. PMID: 20139706.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
-
Sequential formation of ion pairs during activation of a sodium channel voltage sensor. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22498-503.
DeCaen PG, Yarov-Yarovoy V, Sharp EM, Scheuer T, Catterall WA. PMID: 20007787; PMCID: PMC2799717.
View in:
PubMed Mentions:
84 Fields:
Translation:
Cells
-
Interactions of H562 in the S5 helix with T618 and S621 in the pore helix are important determinants of hERG1 potassium channel structure and function. Biophys J. 2009 May 06; 96(9):3600-10.
Lees-Miller JP, Subbotina JO, Guo J, Yarov-Yarovoy V, Noskov SY, Duff HJ. PMID: 19413965; PMCID: PMC2711401.
View in:
PubMed Mentions:
21 Fields:
Translation:
HumansCells
-
Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation. Proc Natl Acad Sci U S A. 2008 Sep 30; 105(39):15142-7.
DeCaen PG, Yarov-Yarovoy V, Zhao Y, Scheuer T, Catterall WA. PMID: 18809926; PMCID: PMC2567506.
View in:
PubMed Mentions:
79 Fields:
Translation:
Cells
-
Closing in on the resting state of the Shaker K(+) channel. Neuron. 2007 Oct 04; 56(1):124-40.
Pathak MM, Yarov-Yarovoy V, Agarwal G, Roux B, Barth P, Kohout S, Tombola F, Isacoff EY. PMID: 17920020.
View in:
PubMed Mentions:
187 Fields:
Translation:
AnimalsCells
-
Interdomain interaction in the FimH adhesin of Escherichia coli regulates the affinity to mannose. J Biol Chem. 2007 Aug 10; 282(32):23437-46.
Aprikian P, Tchesnokova V, Kidd B, Yakovenko O, Yarov-Yarovoy V, Trinchina E, Vogel V, Thomas W, Sokurenko E. PMID: 17567583.
View in:
PubMed Mentions:
59 Fields:
Translation:
AnimalsCells
-
Voltage-gated ion channels and gating modifier toxins. Toxicon. 2007 Feb; 49(2):124-41.
Catterall WA, Cestèle S, Yarov-Yarovoy V, Yu FH, Konoki K, Scheuer T. PMID: 17239913.
View in:
PubMed Mentions:
221 Fields:
Translation:
HumansAnimalsCells
-
Autoinhibitory control of the CaV1.2 channel by its proteolytically processed distal C-terminal domain. J Physiol. 2006 Oct 01; 576(Pt 1):87-102.
Hulme JT, Yarov-Yarovoy V, Lin TW, Scheuer T, Catterall WA. PMID: 16809371; PMCID: PMC1995633.
View in:
PubMed Mentions:
102 Fields:
Translation:
AnimalsCells
-
Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin. J Biol Chem. 2006 Jul 28; 281(30):21332-21344.
Cestèle S, Yarov-Yarovoy V, Qu Y, Sampieri F, Scheuer T, Catterall WA. PMID: 16679310; PMCID: PMC1551974.
View in:
PubMed Mentions:
57 Fields:
Translation:
HumansCells
-
Voltage sensor conformations in the open and closed states in ROSETTA structural models of K(+) channels. Proc Natl Acad Sci U S A. 2006 May 09; 103(19):7292-7.
Yarov-Yarovoy V, Baker D, Catterall WA. PMID: 16648251; PMCID: PMC1464335.
View in:
PubMed Mentions:
135 Fields:
Translation:
Cells
-
Multipass membrane protein structure prediction using Rosetta. Proteins. 2006 Mar 01; 62(4):1010-25.
Yarov-Yarovoy V, Schonbrun J, Baker D. PMID: 16372357; PMCID: PMC1479309.
View in:
PubMed Mentions:
177 Fields:
Translation:
Cells
-
Overview of molecular relationships in the voltage-gated ion channel superfamily. Pharmacol Rev. 2005 Dec; 57(4):387-95.
Yu FH, Yarov-Yarovoy V, Gutman GA, Catterall WA. PMID: 16382097.
View in:
PubMed Mentions:
207 Fields:
Translation:
HumansAnimalsCells
-
A gating hinge in Na+ channels; a molecular switch for electrical signaling. Neuron. 2004 Mar 25; 41(6):859-65.
Zhao Y, Yarov-Yarovoy V, Scheuer T, Catterall WA. PMID: 15046719.
View in:
PubMed Mentions:
63 Fields:
Translation:
HumansCells
-
Differential interactions of lamotrigine and related drugs with transmembrane segment IVS6 of voltage-gated sodium channels. Neuropharmacology. 2003 Mar; 44(3):413-22.
Liu G, Yarov-Yarovoy V, Nobbs M, Clare JJ, Scheuer T, Catterall WA. PMID: 12604088.
View in:
PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
-
Role of amino acid residues in transmembrane segments IS6 and IIS6 of the Na+ channel alpha subunit in voltage-dependent gating and drug block. J Biol Chem. 2002 Sep 20; 277(38):35393-401.
Yarov-Yarovoy V, McPhee JC, Idsvoog D, Pate C, Scheuer T, Catterall WA. PMID: 12130650.
View in:
PubMed Mentions:
103 Fields:
Translation:
AnimalsCells
-
Molecular determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na(+) channel alpha subunit. J Biol Chem. 2001 Jan 05; 276(1):20-7.
Yarov-Yarovoy V, Brown J, Sharp EM, Clare JJ, Scheuer T, Catterall WA. PMID: 11024055.
View in:
PubMed Mentions:
97 Fields:
Translation:
AnimalsCells
-
State-dependent inhibition of the mitochondrial KATP channel by glyburide and 5-hydroxydecanoate. J Biol Chem. 1998 May 29; 273(22):13578-82.
Jaburek M, Yarov-Yarovoy V, Paucek P, Garlid KD. PMID: 9593694.
View in:
PubMed Mentions:
67 Fields:
Translation:
AnimalsCells
-
Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+ channels. Possible mechanism of cardioprotection. Circ Res. 1997 Dec; 81(6):1072-82.
Garlid KD, Paucek P, Yarov-Yarovoy V, Murray HN, Darbenzio RB, D'Alonzo AJ, Lodge NJ, Smith MA, Grover GJ. PMID: 9400389.
View in:
PubMed Mentions:
225 Fields:
Translation:
AnimalsCells
-
The nucleotide regulatory sites on the mitochondrial KATP channel face the cytosol. Biochim Biophys Acta. 1997 Aug 22; 1321(2):128-36.
Yarov-Yarovoy V, Paucek P, Jaburek M, Garlid KD. PMID: 9332501.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
-
Inhibition of the mitochondrial KATP channel by long-chain acyl-CoA esters and activation by guanine nucleotides. J Biol Chem. 1996 Dec 13; 271(50):32084-8.
Paucek P, Yarov-Yarovoy V, Sun X, Garlid KD. PMID: 8943260.
View in:
PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
-
The mitochondrial KATP channel as a receptor for potassium channel openers. J Biol Chem. 1996 Apr 12; 271(15):8796-9.
Garlid KD, Paucek P, Yarov-Yarovoy V, Sun X, Schindler PA. PMID: 8621517.
View in:
PubMed Mentions:
92 Fields:
Translation:
AnimalsCells