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Igor Vorobyov

Title(s)Assistant Professor, Physiology and Membrane Biology
SchoolUniversity of California, Davis
Phone530-752-3932
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Flood E, Boiteux C, Lev B, Vorobyov I, Allen TW. Atomistic Simulations of Membrane Ion Channel Conduction, Gating, and Modulation. Chem Rev. 2019 Jul 10; 119(13):7737-7832. PMID: 31246417.
      View in: PubMed
    2. Yang PC, Purawat S, Ieong PU, Jeng MT, DeMarco KR, Vorobyov I, McCulloch AD, Altintas I, Amaro RE, Clancy CE. A demonstration of modularity, reuse, reproducibility, portability and scalability for modeling and simulation of cardiac electrophysiology using Kepler Workflows. PLoS Comput Biol. 2019 03; 15(3):e1006856. PMID: 30849072.
      View in: PubMed
    3. Nguyen PT, DeMarco KR, Vorobyov I, Clancy CE, Yarov-Yarovoy V. Structural basis for antiarrhythmic drug interactions with the human cardiac sodium channel. Proc Natl Acad Sci U S A. 2019 02 19; 116(8):2945-2954. PMID: 30728299.
      View in: PubMed
    4. DeMarco KR, Bekker S, Vorobyov I. Challenges and advances in atomistic simulations of potassium and sodium ion channel gating and permeation. J Physiol. 2019 02; 597(3):679-698. PMID: 30471114.
      View in: PubMed
    5. Alhadeff R, Vorobyov I, Yoon HW, Warshel A. Exploring the free-energy landscape of GPCR activation. Proc Natl Acad Sci U S A. 2018 10 09; 115(41):10327-10332. PMID: 30257944.
      View in: PubMed
    6. Vorobyov I, Clancy CE. Sex, drugs, and funky rhythms. Heart Rhythm. 2018 04; 15(4):485-486. PMID: 29605014.
      View in: PubMed
    7. DeMarco KR, Bekker S, Clancy CE, Noskov SY, Vorobyov I. Digging into Lipid Membrane Permeation for Cardiac Ion Channel Blocker d-Sotalol with All-Atom Simulations. Front Pharmacol. 2018; 9:26. PMID: 29449809.
      View in: PubMed
    8. Yang PC, Perissinotti LL, López-Redondo F, Wang Y, DeMarco KR, Jeng MT, Vorobyov I, Harvey RD, Kurokawa J, Noskov SY, Clancy CE. A multiscale computational modelling approach predicts mechanisms of female sex risk in the setting of arousal-induced arrhythmias. J Physiol. 2017 07 15; 595(14):4695-4723. PMID: 28516454.
      View in: PubMed
    9. Vorobyov I, Kim I, Chu ZT, Warshel A. Refining the treatment of membrane proteins by coarse-grained models. Proteins. 2016 Jan; 84(1):92-117. PMID: 26531155.
      View in: PubMed
    10. Boiteux C, Vorobyov I, French RJ, French C, Yarov-Yarovoy V, Allen TW. Local anesthetic and antiepileptic drug access and binding to a bacterial voltage-gated sodium channel. Proc Natl Acad Sci U S A. 2014 Sep 09; 111(36):13057-62. PMID: 25136136.
      View in: PubMed
    11. Boiteux C, Vorobyov I, Allen TW. Ion conduction and conformational flexibility of a bacterial voltage-gated sodium channel. Proc Natl Acad Sci U S A. 2014 Mar 04; 111(9):3454-9. PMID: 24550503.
      View in: PubMed
    12. Vorobyov I, Olson TE, Kim JH, Koeppe RE, Andersen OS, Allen TW. Ion-induced defect permeation of lipid membranes. Biophys J. 2014 Feb 04; 106(3):586-97. PMID: 24507599.
      View in: PubMed
    13. Li L, Vorobyov I, Allen TW. The different interactions of lysine and arginine side chains with lipid membranes. J Phys Chem B. 2013 Oct 10; 117(40):11906-20. PMID: 24007457.
      View in: PubMed
    14. Vorobyov I, Bennett WF, Tieleman DP, Allen TW, Noskov S. The Role of Atomic Polarization in the Thermodynamics of Chloroform Partitioning to Lipid Bilayers. J Chem Theory Comput. 2012 Feb 14; 8(2):618-28. PMID: 26596610.
      View in: PubMed
    15. Li LB, Vorobyov I, Allen TW. The role of membrane thickness in charged protein-lipid interactions. Biochim Biophys Acta. 2012 Feb; 1818(2):135-45. PMID: 22063722.
      View in: PubMed
    16. Vorobyov I, Allen TW. On the role of anionic lipids in charged protein interactions with membranes. Biochim Biophys Acta. 2011 Jun; 1808(6):1673-83. PMID: 21073855.
      View in: PubMed
    17. Klauda JB, Venable RM, Freites JA, O'Connor JW, Tobias DJ, Mondragon-Ramirez C, Vorobyov I, MacKerell AD, Pastor RW. Update of the CHARMM all-atom additive force field for lipids: validation on six lipid types. J Phys Chem B. 2010 Jun 17; 114(23):7830-43. PMID: 20496934.
      View in: PubMed
    18. Vorobyov I, Bekker B, Allen TW. Electrostatics of deformable lipid membranes. Biophys J. 2010 Jun 16; 98(12):2904-13. PMID: 20550903.
      View in: PubMed
    19. Vanommeslaeghe K, Hatcher E, Acharya C, Kundu S, Zhong S, Shim J, Darian E, Guvench O, Lopes P, Vorobyov I, Mackerell AD. CHARMM general force field: A force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields. J Comput Chem. 2010 Mar; 31(4):671-90. PMID: 19575467.
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    20. Yu H, Whitfield TW, Harder E, Lamoureux G, Vorobyov I, Anisimov VM, Mackerell AD, Roux B. Simulating Monovalent and Divalent Ions in Aqueous Solution Using a Drude Polarizable Force Field. J Chem Theory Comput. 2010; 6(3):774-786. PMID: 20300554.
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    21. Li L, Vorobyov I, Allen TW. Potential of mean force and pKa profile calculation for a lipid membrane-exposed arginine side chain. J Phys Chem B. 2008 Aug 14; 112(32):9574-87. PMID: 18636765.
      View in: PubMed
    22. Vorobyov I, Li L, Allen TW. Assessing atomistic and coarse-grained force fields for protein-lipid interactions: the formidable challenge of an ionizable side chain in a membrane. J Phys Chem B. 2008 Aug 14; 112(32):9588-602. PMID: 18636764.
      View in: PubMed
    23. Li L, Vorobyov I, MacKerell AD, Allen TW. Is arginine charged in a membrane? Biophys J. 2008 Jan 15; 94(2):L11-3. PMID: 17981901.
      View in: PubMed
    24. Vorobyov I, Anisimov VM, Greene S, Venable RM, Moser A, Pastor RW, MacKerell AD. Additive and Classical Drude Polarizable Force Fields for Linear and Cyclic Ethers. J Chem Theory Comput. 2007 May; 3(3):1120-33. PMID: 26627431.
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    25. Anisimov VM, Vorobyov IV, Roux B, Mackerell AD. Polarizable empirical force field for the primary and secondary alcohol series based on the classical Drude model. J Chem Theory Comput. 2007; 3(6):1927-1946. PMID: 18802495.
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    26. Harder E, Anisimov VM, Vorobyov IV, Lopes PE, Noskov SY, MacKerell AD, Roux B. Atomic Level Anisotropy in the Electrostatic Modeling of Lone Pairs for a Polarizable Force Field Based on the Classical Drude Oscillator. J Chem Theory Comput. 2006 Nov; 2(6):1587-97. PMID: 26627029.
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    27. Vorobyov IV, Anisimov VM, MacKerell AD. Polarizable empirical force field for alkanes based on the classical Drude oscillator model. J Phys Chem B. 2005 Oct 13; 109(40):18988-99. PMID: 16853445.
      View in: PubMed
    28. Anisimov VM, Lamoureux G, Vorobyov IV, Huang N, Roux B, MacKerell AD. Determination of Electrostatic Parameters for a Polarizable Force Field Based on the Classical Drude Oscillator. J Chem Theory Comput. 2005 Jan; 1(1):153-68. PMID: 26641126.
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    29. Yappert MC, Rujoi M, Borchman D, Vorobyov I, Estrada R. Glycero- versus sphingo-phospholipids: correlations with human and non-human mammalian lens growth. Exp Eye Res. 2003 Jun; 76(6):725-34. PMID: 12742355.
      View in: PubMed
    30. Talbott CM, Vorobyov I, Borchman D, Taylor KG, DuPré DB, Yappert MC. Conformational studies of sphingolipids by NMR spectroscopy. II. Sphingomyelin. Biochim Biophys Acta. 2000 Aug 25; 1467(2):326-37. PMID: 11030591.
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