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Crystal M Ripplinger

Title(s)Associate Professor, Pharmacology
SchoolUniversity of California, Davis
Phone530-752-1569
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    Collapse Research 
    Collapse Research Activities and Funding
    Sympathetic remodeling and ventricular arrhythmia
    NIH/NHLBI R01HL111600Apr 16, 2012 - Nov 30, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wang L, Morotti S, Tapa S, Francis Stuart SD, Jiang Y, Wang Z, Myles RC, Brack KE, Ng GA, Bers DM, Grandi E, Ripplinger CM. Different paths, same destination: divergent action potential responses produce conserved cardiac fight-or-flight response in mouse and rabbit hearts. J Physiol. 2019 Jun 19. PMID: 31215643.
      View in: PubMed
    2. Grandi E, Ripplinger CM. Antiarrhythmic mechanisms of beta blocker therapy. Pharmacol Res. 2019 May 14; 146:104274. PMID: 31100336.
      View in: PubMed
    3. Wang L, Ripplinger CM. Putting the pieces together using in vivo optical mapping. Cardiovasc Res. 2019 Mar 29. PMID: 30924872.
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    4. Lindsey ML, Jung M, Yabluchanskiy A, Cannon PL, Iyer RP, Flynn ER, DeLeon-Pennell KY, Valerio FM, Harrison CL, Ripplinger CM, Hall ME, Ma Y. Exogenous CXCL4 infusion inhibits macrophage phagocytosis by limiting CD36 signalling to enhance post-myocardial infarction cardiac dilation and mortality. Cardiovasc Res. 2019 Feb 01; 115(2):395-408. PMID: 30169632.
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    5. Wang Z, Wang L, Tapa S, Pinkerton KE, Chen CY, Ripplinger CM. Exposure to Secondhand Smoke and Arrhythmogenic Cardiac Alternans in a Mouse Model. Environ Health Perspect. 2018 12; 126(12):127001. PMID: 30675795.
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    6. Francis Stuart SD, Wang L, Woodard WR, Ng GA, Habecker BA, Ripplinger CM. Age-related changes in cardiac electrophysiology and calcium handling in response to sympathetic nerve stimulation. J Physiol. 2018 09; 596(17):3977-3991. PMID: 29938794.
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    7. Ripplinger CM. The best thing since sliced bread? Optical mapping of transverse cardiac slices in the mouse heart. J Physiol. 2018 09; 596(17):3825-3826. PMID: 29974471.
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    8. Lindsey ML, Bolli R, Canty JM, Du XJ, Frangogiannis NG, Frantz S, Gourdie RG, Holmes JW, Jones SP, Kloner RA, Lefer DJ, Liao R, Murphy E, Ping P, Przyklenk K, Recchia FA, Schwartz Longacre L, Ripplinger CM, Van Eyk JE, Heusch G. Guidelines for experimental models of myocardial ischemia and infarction. Am J Physiol Heart Circ Physiol. 2018 04 01; 314(4):H812-H838. PMID: 29351451.
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    9. Parrish DC, Francis Stuart SD, Olivas A, Wang L, Nykjaer A, Ripplinger CM, Habecker BA. Transient denervation of viable myocardium after myocardial infarction does not alter arrhythmia susceptibility. Am J Physiol Heart Circ Physiol. 2018 03 01; 314(3):H415-H423. PMID: 29101167.
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    10. Lang D, Sato D, Jiang Y, Ginsburg KS, Ripplinger CM, Bers DM. Calcium-Dependent Arrhythmogenic Foci Created by Weakly Coupled Myocytes in the Failing Heart. Circ Res. 2017 Dec 08; 121(12):1379-1391. PMID: 28970285.
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    11. Ripplinger CM. From drugs to devices and back again: chemical vagal nerve stimulation for the treatment of heart failure. Cardiovasc Res. 2017 09 01; 113(11):1270-1272. PMID: 28859301.
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    12. Murphy SR, Wang L, Wang Z, Domondon P, Lang D, Habecker BA, Myles RC, Ripplinger CM. ß-Adrenergic Inhibition Prevents Action Potential and Calcium Handling Changes during Regional Myocardial Ischemia. Front Physiol. 2017; 8:630. PMID: 28894423.
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    13. Zucker IH, Lindsey ML, Delmar M, De Windt LJ, Des Rosiers C, Diz DI, Hester RL, Jones SP, Kanagy NL, Kitakaze M, Liao R, Lopaschuk GD, Patel KP, Recchia FA, Sadoshima J, Shah AM, Ungvari Z, Benjamin IJ, Blaustein MP, Charkoudian N, Efimov IR, Gutterman D, Kass DA, Liao Y, O'Leary DS, Ripplinger CM, Wolin MS. Why publish in the American Journal of Physiology-Heart and Circulatory Physiology? Am J Physiol Heart Circ Physiol. 2017 08 01; 313(2):H221-H223. PMID: 28626081.
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    14. De Jesus NM, Wang L, Lai J, Rigor RR, Francis Stuart SD, Bers DM, Lindsey ML, Ripplinger CM. Antiarrhythmic effects of interleukin 1 inhibition after myocardial infarction. Heart Rhythm. 2017 05; 14(5):727-736. PMID: 28111350.
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    15. Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, Bers DM, Nerbonne JM. Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics. J Physiol. 2017 04 01; 595(7):2229-2252. PMID: 27808412.
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    16. Habecker BA, Anderson ME, Birren SJ, Fukuda K, Herring N, Hoover DB, Kanazawa H, Paterson DJ, Ripplinger CM. Molecular and cellular neurocardiology: development, and cellular and molecular adaptations to heart disease. J Physiol. 2016 07 15; 594(14):3853-75. PMID: 27060296.
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    17. Sirish P, Li N, Timofeyev V, Zhang XD, Wang L, Yang J, Lee KS, Bettaieb A, Ma SM, Lee JH, Su D, Lau VC, Myers RE, Lieu DK, López JE, Young JN, Yamoah EN, Haj F, Ripplinger CM, Hammock BD, Chiamvimonvat N. Molecular Mechanisms and New Treatment Paradigm for Atrial Fibrillation. Circ Arrhythm Electrophysiol. 2016 May; 9(5). PMID: 27162031.
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    18. Gardner RT, Ripplinger CM, Myles RC, Habecker BA. Molecular Mechanisms of Sympathetic Remodeling and Arrhythmias. Circ Arrhythm Electrophysiol. 2016 Feb; 9(2):e001359. PMID: 26810594.
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    19. Olivas A, Gardner RT, Wang L, Ripplinger CM, Woodward WR, Habecker BA. Myocardial Infarction Causes Transient Cholinergic Transdifferentiation of Cardiac Sympathetic Nerves via gp130. J Neurosci. 2016 Jan 13; 36(2):479-88. PMID: 26758839.
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    20. Ripplinger CM, Noujaim SF, Linz D. The nervous heart. Prog Biophys Mol Biol. 2016 Jan; 120(1-3):199-209. PMID: 26780507.
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    21. Quinn TA, Ripplinger CM. Recent developments in biophysics & molecular biology of heart rhythm. Prog Biophys Mol Biol. 2016 Jan; 120(1-3):1-2. PMID: 26777585.
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    22. Francis Stuart SD, De Jesus NM, Lindsey ML, Ripplinger CM. The crossroads of inflammation, fibrosis, and arrhythmia following myocardial infarction. J Mol Cell Cardiol. 2016 Feb; 91:114-22. PMID: 26739214.
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    23. Wang L, De Jesus NM, Ripplinger CM. Optical Mapping of Intra-Sarcoplasmic Reticulum Ca2+ and Transmembrane Potential in the Langendorff-perfused Rabbit Heart. J Vis Exp. 2015 Sep 10; (103). PMID: 26382577.
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    24. Bartos DC, Grandi E, Ripplinger CM. Ion Channels in the Heart. Compr Physiol. 2015 Jul 01; 5(3):1423-64. PMID: 26140724.
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    25. Ripplinger CM, Efimov IR. Dual Vm/Ca imaging of premature ventricular contractions: bridging the gap of anatomical scales. Circ Arrhythm Electrophysiol. 2015 Jun; 8(3):529-30. PMID: 26082526.
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    26. Hammer KP, Ljubojevic S, Ripplinger CM, Pieske BM, Bers DM. Cardiac myocyte alternans in intact heart: Influence of cell-cell coupling and ß-adrenergic stimulation. J Mol Cell Cardiol. 2015 Jul; 84:1-9. PMID: 25828762.
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    27. Ripplinger CM. A leap(frog) forward in understanding focal arrhythmia. J Physiol. 2015 Mar 15; 593(6):1383-4. PMID: 25772292.
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    28. Gardner RT, Wang L, Lang BT, Cregg JM, Dunbar CL, Woodward WR, Silver J, Ripplinger CM, Habecker BA. Targeting protein tyrosine phosphatase s after myocardial infarction restores cardiac sympathetic innervation and prevents arrhythmias. Nat Commun. 2015 Feb 02; 6:6235. PMID: 25639594.
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    29. Ripplinger CM. Mouse models of cardiac conduction system markers: revealing the past, present, and future of pacemaking and conduction. Trends Cardiovasc Med. 2015 Jan; 25(1):10-1. PMID: 25446050.
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    30. De Jesus NM, Wang L, Herren AW, Wang J, Shenasa F, Bers DM, Lindsey ML, Ripplinger CM. Atherosclerosis exacerbates arrhythmia following myocardial infarction: Role of myocardial inflammation. Heart Rhythm. 2015 Jan; 12(1):169-78. PMID: 25304682.
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    31. Myles RC, Wang L, Bers DM, Ripplinger CM. Decreased inward rectifying K+ current and increased ryanodine receptor sensitivity synergistically contribute to sustained focal arrhythmia in the intact rabbit heart. J Physiol. 2015 Mar 15; 593(6):1479-93. PMID: 25772297.
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    32. Satkunananthan PB, Anderson MJ, De Jesus NM, Haudenschild DR, Ripplinger CM, Christiansen BA. In vivo fluorescence reflectance imaging of protease activity in a mouse model of post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2014 Oct; 22(10):1461-9. PMID: 25278057.
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    33. DeLeon-Pennell KY, de Castro Brás LE, Iyer RP, Bratton DR, Jin YF, Ripplinger CM, Lindsey ML. P. gingivalis lipopolysaccharide intensifies inflammation post-myocardial infarction through matrix metalloproteinase-9. J Mol Cell Cardiol. 2014 Nov; 76:218-26. PMID: 25240641.
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    34. Wang L, Myles RC, De Jesus NM, Ohlendorf AK, Bers DM, Ripplinger CM. Optical mapping of sarcoplasmic reticulum Ca2+ in the intact heart: ryanodine receptor refractoriness during alternans and fibrillation. Circ Res. 2014 Apr 25; 114(9):1410-21. PMID: 24568740.
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    35. Feinberg AW, Ripplinger CM, van der Meer P, Sheehy SP, Domian I, Chien KR, Parker KK. Functional differences in engineered myocardium from embryonic stem cell-derived versus neonatal cardiomyocytes. Stem Cell Reports. 2013; 1(5):387-96. PMID: 24286027.
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    36. Erickson JR, Pereira L, Wang L, Han G, Ferguson A, Dao K, Copeland RJ, Despa F, Hart GW, Ripplinger CM, Bers DM. Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation. Nature. 2013 Oct 17; 502(7471):372-6. PMID: 24077098.
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    37. Ripplinger CM, Kessinger CW, Li C, Kim JW, McCarthy JR, Weissleder R, Henke PK, Lin CP, Jaffer FA. Inflammation modulates murine venous thrombosis resolution in vivo: assessment by multimodal fluorescence molecular imaging. Arterioscler Thromb Vasc Biol. 2012 Nov; 32(11):2616-24. PMID: 22995524.
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    38. Nawroth JC, Lee H, Feinberg AW, Ripplinger CM, McCain ML, Grosberg A, Dabiri JO, Parker KK. A tissue-engineered jellyfish with biomimetic propulsion. Nat Biotechnol. 2012 Aug; 30(8):792-7. PMID: 22820316.
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    39. Sondergaard CS, Mathews G, Wang L, Jeffreys A, Sahota A, Wood M, Ripplinger CM, Si MS. Contractile and electrophysiologic characterization of optimized self-organizing engineered heart tissue. Ann Thorac Surg. 2012 Oct; 94(4):1241-8; discussion 1249. PMID: 22795054.
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    40. Feinberg AW, Alford PW, Jin H, Ripplinger CM, Werdich AA, Sheehy SP, Grosberg A, Parker KK. Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture. Biomaterials. 2012 Aug; 33(23):5732-41. PMID: 22594976.
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    41. Myles RC, Wang L, Kang C, Bers DM, Ripplinger CM. Local ß-adrenergic stimulation overcomes source-sink mismatch to generate focal arrhythmia. Circ Res. 2012 May 25; 110(11):1454-64. PMID: 22539768.
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    42. Ripplinger CM, Bers DM. Human biological pacemakers: intrinsic variability and stability. Circulation. 2012 Feb 21; 125(7):856-8. PMID: 22261197.
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    43. Moreno JD, Zhu ZI, Yang PC, Bankston JR, Jeng MT, Kang C, Wang L, Bayer JD, Christini DJ, Trayanova NA, Ripplinger CM, Kass RS, Clancy CE. A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms. Sci Transl Med. 2011 Aug 31; 3(98):98ra83. PMID: 21885405.
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    44. Ambrosi CM, Ripplinger CM, Efimov IR, Fedorov VV. Termination of sustained atrial flutter and fibrillation using low-voltage multiple-shock therapy. Heart Rhythm. 2011 Jan; 8(1):101-8. PMID: 20969974.
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    45. Li W, Ripplinger CM, Lou Q, Efimov IR. Multiple monophasic shocks improve electrotherapy of ventricular tachycardia in a rabbit model of chronic infarction. Heart Rhythm. 2009 Jul; 6(7):1020-7. PMID: 19560090.
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    46. Lombardi R, Rodriguez G, Chen SN, Ripplinger CM, Li W, Chen J, Willerson JT, Betocchi S, Wickline SA, Efimov IR, Marian AJ. Resolution of established cardiac hypertrophy and fibrosis and prevention of systolic dysfunction in a transgenic rabbit model of human cardiomyopathy through thiol-sensitive mechanisms. Circulation. 2009 Mar 17; 119(10):1398-407. PMID: 19255346.
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    47. Ripplinger CM, Lou Q, Li W, Hadley J, Efimov IR. Panoramic imaging reveals basic mechanisms of induction and termination of ventricular tachycardia in rabbit heart with chronic infarction: implications for low-voltage cardioversion. Heart Rhythm. 2009 Jan; 6(1):87-97. PMID: 18996057.
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    48. Hucker WJ, Ripplinger CM, Fleming CP, Fedorov VV, Rollins AM, Efimov IR. Bimodal biophotonic imaging of the structure-function relationship in cardiac tissue. J Biomed Opt. 2008 Sep-Oct; 13(5):054012. PMID: 19021392.
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    49. Lou Q, Ripplinger CM, Bayly PV, Efimov IR. Quantitative panoramic imaging of epicardial electrical activity. Ann Biomed Eng. 2008 Oct; 36(10):1649-58. PMID: 18654852.
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    50. Fleming CP, Ripplinger CM, Webb B, Efimov IR, Rollins AM. Quantification of cardiac fiber orientation using optical coherence tomography. J Biomed Opt. 2008 May-Jun; 13(3):030505. PMID: 18601522.
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    51. Ripplinger CM, Li W, Hadley J, Chen J, Rothenberg F, Lombardi R, Wickline SA, Marian AJ, Efimov IR. Enhanced transmural fiber rotation and connexin 43 heterogeneity are associated with an increased upper limit of vulnerability in a transgenic rabbit model of human hypertrophic cardiomyopathy. Circ Res. 2007 Nov 09; 101(10):1049-57. PMID: 17885214.
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    52. Qu F, Ripplinger CM, Nikolski VP, Grimm C, Efimov IR. Three-dimensional panoramic imaging of cardiac arrhythmias in rabbit heart. J Biomed Opt. 2007 Jul-Aug; 12(4):044019. PMID: 17867823.
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    53. Ahlberg SE, Ripplinger CM, Skadsberg ND, Iaizzo PA, Mulligan LJ. Effects of pacing rate on mechanical restitution within the in vivo canine heart: study of the force-frequency relationship. J Cardiovasc Electrophysiol. 2007 Feb; 18(2):212-7. PMID: 17239141.
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    54. Efimov I, Ripplinger CM. Virtual electrode hypothesis of defibrillation. Heart Rhythm. 2006 Sep; 3(9):1100-2. PMID: 16945810.
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    55. Ripplinger CM, Krinsky VI, Nikolski VP, Efimov IR. Mechanisms of unpinning and termination of ventricular tachycardia. Am J Physiol Heart Circ Physiol. 2006 Jul; 291(1):H184-92. PMID: 16501014.
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    56. Efimov IR, Ripplinger CM. Tornado in a dish: revealing the mechanisms of ventricular arrhythmias in engineered cardiac tissues. Cardiovasc Res. 2006 Feb 01; 69(2):307-8. PMID: 16325163.
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    57. Byrd GD, Prasad SM, Ripplinger CM, Cassilly TR, Schuessler RB, Boineau JP, Damiano RJ. Importance of geometry and refractory period in sustaining atrial fibrillation: testing the critical mass hypothesis. Circulation. 2005 Aug 30; 112(9 Suppl):I7-13. PMID: 16159868.
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    58. Ripplinger CM, Ewert DL, Koenig SC. Toward a new method of analyzing cardiac performance. Biomed Sci Instrum. 2001; 37:313-8. PMID: 11347409.
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