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Dominik R Haudenschild, PhD

Title(s)Professor, Orthopaedic Surgery
SchoolUniversity of California, Davis
AddressResearch I/UCDMC
CA 95817
Phone916-734-5015
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    Collapse Research 
    Collapse Research Activities and Funding
    Multivalent Presentation of Growth Factors Regulates Cellular Responses
    NIH/NIAMS R01AR070239Apr 10, 2017 - Jan 31, 2022
    Role: Principal Investigator
    Novel Early Intervention to Prevent Post-Traumatic Osteoarthritis
    NIH/NIAMS R21AR063348Aug 1, 2012 - May 31, 2014
    Role: Principal Investigator
    Identification of Mechanoresponsive Promoter Elements in Chondrogenesis
    NIH/NIAMS R03AR061038Apr 1, 2011 - Mar 31, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. NADPH oxidases in bone and cartilage homeostasis and disease: A promising therapeutic target. J Orthop Res. 2020 Apr 14. Wegner AM, Haudenschild DR. PMID: 32285964.
      View in: PubMed   Mentions:    Fields:    
    2. Acute Changes in NADPH Oxidase 4 in Early Post-Traumatic Osteoarthritis. J Orthop Res. 2019 11; 37(11):2429-2436. Wegner AM, Campos NR, Robbins MA, Haddad AF, Cunningham HC, Yik JHN, Christiansen BA, Haudenschild DR. PMID: 31304988.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Label-Free and Direct Visualization of Multivalent Binding of Bone Morphogenetic Protein-2 with Cartilage Oligomeric Matrix Protein. J Phys Chem B. 2019 01 10; 123(1):39-46. Tran V, Karsai A, Fong MC, Cai W, Yik JHN, Klineberg E, Haudenschild DR, Liu GY. PMID: 30554512.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Inhibition of early response genes prevents changes in global joint metabolomic profiles in mouse post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2019 03; 27(3):504-512. Haudenschild DR, Carlson AK, Zignego DL, Yik JHN, Hilmer JK, June RK. PMID: 30572121.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Effects of Micronized Cartilage Matrix on Cartilage Repair in Osteochondral Lesions of the Talus. Cartilage. 2020 Jul; 11(3):316-322. Shieh AK, Singh SG, Nathe C, Lian E, Haudenschild DR, Nolta JA, Lee CA, Giza E, Kreulen CD. PMID: 30156865.
      View in: PubMed   Mentions:    Fields:    
    6. Flavopiridol Protects Bone Tissue by Attenuating RANKL Induced Osteoclast Formation. Front Pharmacol. 2018; 9:174. Hu Z, Chen Y, Song L, Yik JHN, Haudenschild DR, Fan S. PMID: 29773986.
      View in: PubMed   Mentions:
    7. Ca2+-Dependent Regulation of NFATc1 via KCa3.1 in Inflammatory Osteoclastogenesis. J Immunol. 2018 01 15; 200(2):749-757. Grössinger EM, Kang M, Bouchareychas L, Sarin R, Haudenschild DR, Borodinsky LN, Adamopoulos IE. PMID: 29246953.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    8. Stem Cells in Spinal Fusion. Global Spine J. 2017 Dec; 7(8):801-810. Robbins MA, Haudenschild DR, Wegner AM, Klineberg EO. PMID: 29238646.
      View in: PubMed   Mentions:
    9. Binding to COMP Reduces the BMP2 Dose for Spinal Fusion in a Rat Model. Spine (Phila Pa 1976). 2016 Jul 15; 41(14):E829-36. Refaat M, Klineberg EO, Fong MC, Garcia TC, Leach JK, Haudenschild DR. PMID: 26679888.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    10. Inhibition of CDK9 prevents mechanical injury-induced inflammation, apoptosis and matrix degradation in cartilage explants. Eur Cell Mater. 2016; 30:200-9. Hu Z, Yik JH, Cissell DD, Michelier PV, Athanasiou KA, Haudenschild DR. PMID: 26859911.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    11. Articular Cartilage Injury and Potential Remedies. J Orthop Trauma. 2015 Dec; 29 Suppl 12:S47-52. Chubinskaya S, Haudenschild D, Gasser S, Stannard J, Krettek C, Borrelli J. PMID: 26584267.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    12. Non-invasive mouse models of post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2015 Oct; 23(10):1627-38. Christiansen BA, Guilak F, Lockwood KA, Olson SA, Pitsillides AA, Sandell LJ, Silva MJ, van der Meulen MC, Haudenschild DR. PMID: 26003950.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    13. In-vitro and in-vivo imaging of MMP activity in cartilage and joint injury. Biochem Biophys Res Commun. 2015 May 08; 460(3):741-6. Fukui T, Tenborg E, Yik JH, Haudenschild DR. PMID: 25817731.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    14. Effect of alendronate on post-traumatic osteoarthritis induced by anterior cruciate ligament rupture in mice. Arthritis Res Ther. 2015 Feb 16; 17:30. Khorasani MS, Diko S, Hsia AW, Anderson MJ, Genetos DC, Haudenschild DR, Christiansen BA. PMID: 25888819.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    15. Closed Joint ACL Disruption Murine Model of PTA. . 2015 Jan 1; 75-85. Blaine A. Christiansen, Jasper H. N. Yik, Dominik R. Haudenschild. .
      View in: Publisher Site   Mentions:
    16. High abundant protein removal from rodent blood for biomarker discovery. Biochem Biophys Res Commun. 2014 Dec 05; 455(1-2):84-9. Haudenschild DR, Eldridge A, Lein PJ, Chromy BA. PMID: 25445603.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    17. Reply: To PMID 24470357. Arthritis Rheumatol. 2014 Dec; 66(12):3526. Haudenschild DR, Yik JH. PMID: 25154864.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    18. In vivo fluorescence reflectance imaging of protease activity in a mouse model of post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2014 Oct; 22(10):1461-9. Satkunananthan PB, Anderson MJ, De Jesus NM, Haudenschild DR, Ripplinger CM, Christiansen BA. PMID: 25278057.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    19. Cartilage oligomeric matrix protein and its binding partners in the cartilage extracellular matrix: interaction, regulation and role in chondrogenesis. Matrix Biol. 2014 Jul; 37:102-11. Acharya C, Yik JH, Kishore A, Van Dinh V, Di Cesare PE, Haudenschild DR. PMID: 24997222.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    20. Cyclin-dependent kinase 9 inhibition protects cartilage from the catabolic effects of proinflammatory cytokines. Arthritis Rheumatol. 2014 Jun; 66(6):1537-46. Yik JH, Hu Z, Kumari R, Christiansen BA, Haudenschild DR. PMID: 24470357.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    21. The effect of noggin interference in a rabbit posterolateral spinal fusion model. Eur Spine J. 2014 Nov; 23(11):2385-92. Klineberg E, Haudenschild DR, Snow KD, Garitty S, Christiansen BA, Acharya C, Maitra S, Gupta MC. PMID: 24740279.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    22. The Oncogene LRF Stimulates Proliferation of Mesenchymal Stem Cells and Inhibits Their Chondrogenic Differentiation. Cartilage. 2013 Oct; 4(4):329-38. Yik JH, Li H, Acharya C, Kumari R, Fierro F, Haudenschild DR, Nolta J, Di Cesare PE. PMID: 26069677.
      View in: PubMed   Mentions:    Fields:    
    23. Comparison of loading rate-dependent injury modes in a murine model of post-traumatic osteoarthritis. J Orthop Res. 2014 Jan; 32(1):79-88. Lockwood KA, Chu BT, Anderson MJ, Haudenschild DR, Christiansen BA. PMID: 24019199.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    24. Effect of age and cytoskeletal elements on the indentation-dependent mechanical properties of chondrocytes. PLoS One. 2013; 8(4):e61651. Chahine NO, Blanchette C, Thomas CB, Lu J, Haudenschild D, Loots GG. PMID: 23613892.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    25. c-Maf Transcription Factor Regulates ADAMTS-12 Expression in Human Chondrogenic Cells. Cartilage. 2013 Apr; 4(2):177-86. Hong E, Yik J, Amanatullah DF, Di Cesare PE, Haudenschild DR. PMID: 26069660.
      View in: PubMed   Mentions: 1     Fields:    
    26. Cartilage oligomeric matrix protein enhances osteogenesis by directly binding and activating bone morphogenetic protein-2. Bone. 2013 Jul; 55(1):23-35. Ishida K, Acharya C, Christiansen BA, Yik JH, DiCesare PE, Haudenschild DR. PMID: 23528838.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    27. Interactions between FGF21 and BMP-2 in osteogenesis. Biochem Biophys Res Commun. 2013 Mar 22; 432(4):677-82. Ishida K, Haudenschild DR. PMID: 23416071.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    28. Identification of a 3Kbp mechanoresponsive promoter region in the human cartilage oligomeric matrix protein gene. Tissue Eng Part A. 2012 Sep; 18(17-18):1882-9. Amanatullah DF, Lu J, Hecht J, Posey K, Yik J, Di Cesare PE, Haudenschild DR. PMID: 22764748.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    29. The oncogene LRF is a survival factor in chondrosarcoma and contributes to tumor malignancy and drug resistance. Carcinogenesis. 2012 Nov; 33(11):2076-83. Kumari R, Li H, Haudenschild DR, Fierro F, Carlson CS, Overn P, Gupta L, Gupta K, Nolta J, Yik JH, Di Cesare PE. PMID: 22847180.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    30. Musculoskeletal changes following non-invasive knee injury using a novel mouse model of post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2012 Jul; 20(7):773-82. Christiansen BA, Anderson MJ, Lee CA, Williams JC, Yik JH, Haudenschild DR. PMID: 22531459.
      View in: PubMed   Mentions: 53     Fields:    Translation:Animals
    31. Chondrogenic potential and homogeneity of cell populations of donor and recipient cells in a fresh osteochondral allograft: a case report. J Bone Joint Surg Am. 2012 Feb 01; 94(3):e17. Haudenschild DR, Hong E, Hatcher S, Jamali AA. PMID: 22298063.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    32. Enhanced activity of transforming growth factor ß1 (TGF-ß1) bound to cartilage oligomeric matrix protein. J Biol Chem. 2011 Dec 16; 286(50):43250-8. Haudenschild DR, Hong E, Yik JH, Chromy B, Mörgelin M, Snow KD, Acharya C, Takada Y, Di Cesare PE. PMID: 21940632.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    33. Comparative analysis with collagen type II distinguishes cartilage oligomeric matrix protein as a primary TGFß-responsive gene. Osteoarthritis Cartilage. 2011 Oct; 19(10):1246-53. Li H, Haudenschild DR, Posey KL, Hecht JT, Di Cesare PE, Yik JH. PMID: 21843649.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    34. Vimentin contributes to changes in chondrocyte stiffness in osteoarthritis. J Orthop Res. 2011 Jan; 29(1):20-5. Haudenschild DR, Chen J, Pang N, Steklov N, Grogan SP, Lotz MK, D'Lima DD. PMID: 20602472.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    35. Role of c-Maf in Chondrocyte Differentiation: A Review. Cartilage. 2011 Jan; 2(1):27-35. Hong E, Di Cesare PE, Haudenschild DR. PMID: 26069566.
      View in: PubMed   Mentions: 3     Fields:    
    36. Rho kinase-dependent activation of SOX9 in chondrocytes. Arthritis Rheum. 2010 Jan; 62(1):191-200. Haudenschild DR, Chen J, Pang N, Lotz MK, D'Lima DD. PMID: 20039424.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    37. Characterization of the chondrocyte actin cytoskeleton in living three-dimensional culture: response to anabolic and catabolic stimuli. Mol Cell Biomech. 2009 Sep; 6(3):135-44. Haudenschild DR, Chen J, Steklov N, Lotz MK, D'Lima DD. PMID: 19670824.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    38. Rho kinase-dependent CCL20 induced by dynamic compression of human chondrocytes. Arthritis Rheum. 2008 Sep; 58(9):2735-42. Haudenschild DR, Nguyen B, Chen J, D'Lima DD, Lotz MK. PMID: 18759278.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    39. Dynamic compression of chondrocytes induces a Rho kinase-dependent reorganization of the actin cytoskeleton. Biorheology. 2008; 45(3-4):219-28. Haudenschild DR, D'Lima DD, Lotz MK. PMID: 18836226.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    40. Immunolocalization of IL-17A, IL-17B, and their receptors in chondrocytes during fracture healing. J Histochem Cytochem. 2008 Feb; 56(2):89-95. Kokubu T, Haudenschild DR, Moseley TA, Rose L, Reddi AH. PMID: 17827167.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    41. Generation of interleukin-17 receptor-like protein (IL-17RL) in prostate by alternative splicing of RNA. Prostate. 2006 Sep 01; 66(12):1268-74. Haudenschild DR, Curtiss SB, Moseley TA, Reddi AH. PMID: 16688746.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    42. Interleukin-17 receptor-like gene is a novel antiapoptotic gene highly expressed in androgen-independent prostate cancer. Cancer Res. 2006 Jan 01; 66(1):175-83. You Z, Shi XB, DuRaine G, Haudenschild D, Tepper CG, Lo SH, Gandour-Edwards R, de Vere White RW, Reddi AH. PMID: 16397230.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    43. Bone morphogenetic protein (BMP)-6 signaling and BMP antagonist noggin in prostate cancer. Cancer Res. 2004 Nov 15; 64(22):8276-84. Haudenschild DR, Palmer SM, Moseley TA, You Z, Reddi AH. PMID: 15548695.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    44. Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev. 2003 Apr; 14(2):155-74. Moseley TA, Haudenschild DR, Rose L, Reddi AH. PMID: 12651226.
      View in: PubMed   Mentions: 243     Fields:    Translation:Cells
    45. Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer. J Biol Chem. 2002 Feb 08; 277(6):4309-16. Haudenschild D, Moseley T, Rose L, Reddi AH. PMID: 11706037.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    46. Intracranial distribution of the sympathetic system in mice: DiI tracing and immunocytochemical labeling. Anat Rec. 2001 05 01; 263(1):99-111. Maklad A, Quinn T, Fritzsch B. PMID: 11331976.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    47. Expression of a stable articular cartilage phenotype without evidence of hypertrophy by adult human articular chondrocytes in vitro. J Orthop Res. 1998 Mar; 16(2):207-16. Binette F, McQuaid DP, Haudenschild DR, Yaeger PC, McPherson JM, Tubo R. PMID: 9621895.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    48. Cartilage matrix protein: expression patterns in chicken, mouse, and human. Ann N Y Acad Sci. 1996 Jun 08; 785:238-40. Chen Q, Johnson DM, Haudenschild DR, Goetinck PF. PMID: 8702140.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    49. Cartilage matrix protein forms a type II collagen-independent filamentous network: analysis in primary cell cultures with a retrovirus expression system. Mol Biol Cell. 1995 Dec; 6(12):1743-53. Chen Q, Johnson DM, Haudenschild DR, Tondravi MM, Goetinck PF. PMID: 8590802.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    50. Progression and recapitulation of the chondrocyte differentiation program: cartilage matrix protein is a marker for cartilage maturation. Dev Biol. 1995 Nov; 172(1):293-306. Chen Q, Johnson DM, Haudenschild DR, Goetinck PF. PMID: 7589809.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    51. The role of coiled-coil alpha-helices and disulfide bonds in the assembly and stabilization of cartilage matrix protein subunits. A mutational analysis. J Biol Chem. 1995 Sep 29; 270(39):23150-4. Haudenschild DR, Tondravi MM, Hofer U, Chen Q, Goetinck PF. PMID: 7559460.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    52. Link protein is ubiquitously expressed in non-cartilaginous tissues where it enhances and stabilizes the interaction of proteoglycans with hyaluronic acid. J Biol Chem. 1994 Jul 22; 269(29):19116-22. Binette F, Cravens J, Kahoussi B, Haudenschild DR, Goetinck PF. PMID: 8034670.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    53. Cartilage matrix protein binds to collagen and plays a role in collagen fibrillogenesis. Prog Clin Biol Res. 1993; 383B:515-22. Tondravi MM, Winterbottom N, Haudenschild DR, Goetinck PF. PMID: 8115368.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells