Dominik R Haudenschild, PhD

Title(s)Professor, Orthopaedic Surgery
SchoolUniversity of California, Davis
AddressResearch I/UCDMC
CA 95817
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    Collapse Research 
    Collapse Research Activities and Funding
    Multivalent Presentation of Growth Factors Regulates Cellular Responses
    NIH/NIAMS R01AR070239Apr 10, 2017 - Jan 31, 2022
    Role: Principal Investigator
    Novel Early Intervention to Prevent Post-Traumatic Osteoarthritis
    NIH/NIAMS R21AR063348Aug 1, 2012 - May 31, 2014
    Role: Principal Investigator
    Identification of Mechanoresponsive Promoter Elements in Chondrogenesis
    NIH/NIAMS R03AR061038Apr 1, 2011 - Mar 31, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. NADPH oxidases in bone and cartilage homeostasis and disease: A promising therapeutic target. J Orthop Res. 2020 Apr 14. Wegner AM, Haudenschild DR. PMID: 32285964.
      View in: PubMed   Mentions:    Fields:    
    2. Acute Changes in NADPH Oxidase 4 in Early Post-Traumatic Osteoarthritis. J Orthop Res. 2019 11; 37(11):2429-2436. Wegner AM, Campos NR, Robbins MA, Haddad AF, Cunningham HC, Yik JHN, Christiansen BA, Haudenschild DR. PMID: 31304988.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Label-Free and Direct Visualization of Multivalent Binding of Bone Morphogenetic Protein-2 with Cartilage Oligomeric Matrix Protein. J Phys Chem B. 2019 01 10; 123(1):39-46. Tran V, Karsai A, Fong MC, Cai W, Yik JHN, Klineberg E, Haudenschild DR, Liu GY. PMID: 30554512.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Inhibition of early response genes prevents changes in global joint metabolomic profiles in mouse post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2019 03; 27(3):504-512. Haudenschild DR, Carlson AK, Zignego DL, Yik JHN, Hilmer JK, June RK. PMID: 30572121.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Effects of Micronized Cartilage Matrix on Cartilage Repair in Osteochondral Lesions of the Talus. Cartilage. 2020 Jul; 11(3):316-322. Shieh AK, Singh SG, Nathe C, Lian E, Haudenschild DR, Nolta JA, Lee CA, Giza E, Kreulen CD. PMID: 30156865.
      View in: PubMed   Mentions:    Fields:    
    6. Flavopiridol Protects Bone Tissue by Attenuating RANKL Induced Osteoclast Formation. Front Pharmacol. 2018; 9:174. Hu Z, Chen Y, Song L, Yik JHN, Haudenschild DR, Fan S. PMID: 29773986.
      View in: PubMed   Mentions:
    7. Ca2+-Dependent Regulation of NFATc1 via KCa3.1 in Inflammatory Osteoclastogenesis. J Immunol. 2018 01 15; 200(2):749-757. Grössinger EM, Kang M, Bouchareychas L, Sarin R, Haudenschild DR, Borodinsky LN, Adamopoulos IE. PMID: 29246953.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    8. Stem Cells in Spinal Fusion. Global Spine J. 2017 Dec; 7(8):801-810. Robbins MA, Haudenschild DR, Wegner AM, Klineberg EO. PMID: 29238646.
      View in: PubMed   Mentions:
    9. Binding to COMP Reduces the BMP2 Dose for Spinal Fusion in a Rat Model. Spine (Phila Pa 1976). 2016 Jul 15; 41(14):E829-36. Refaat M, Klineberg EO, Fong MC, Garcia TC, Leach JK, Haudenschild DR. PMID: 26679888.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    10. Inhibition of CDK9 prevents mechanical injury-induced inflammation, apoptosis and matrix degradation in cartilage explants. Eur Cell Mater. 2016; 30:200-9. Hu Z, Yik JH, Cissell DD, Michelier PV, Athanasiou KA, Haudenschild DR. PMID: 26859911.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    11. Articular Cartilage Injury and Potential Remedies. J Orthop Trauma. 2015 Dec; 29 Suppl 12:S47-52. Chubinskaya S, Haudenschild D, Gasser S, Stannard J, Krettek C, Borrelli J. PMID: 26584267.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    12. Non-invasive mouse models of post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2015 Oct; 23(10):1627-38. Christiansen BA, Guilak F, Lockwood KA, Olson SA, Pitsillides AA, Sandell LJ, Silva MJ, van der Meulen MC, Haudenschild DR. PMID: 26003950.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    13. In-vitro and in-vivo imaging of MMP activity in cartilage and joint injury. Biochem Biophys Res Commun. 2015 May 08; 460(3):741-6. Fukui T, Tenborg E, Yik JH, Haudenschild DR. PMID: 25817731.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    14. Effect of alendronate on post-traumatic osteoarthritis induced by anterior cruciate ligament rupture in mice. Arthritis Res Ther. 2015 Feb 16; 17:30. Khorasani MS, Diko S, Hsia AW, Anderson MJ, Genetos DC, Haudenschild DR, Christiansen BA. PMID: 25888819.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    15. Closed Joint ACL Disruption Murine Model of PTA. . 2015 Jan 1; 75-85. Blaine A. Christiansen, Jasper H. N. Yik, Dominik R. Haudenschild. .
      View in: Publisher Site   Mentions:
    16. High abundant protein removal from rodent blood for biomarker discovery. Biochem Biophys Res Commun. 2014 Dec 05; 455(1-2):84-9. Haudenschild DR, Eldridge A, Lein PJ, Chromy BA. PMID: 25445603.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    17. Reply: To PMID 24470357. Arthritis Rheumatol. 2014 Dec; 66(12):3526. Haudenschild DR, Yik JH. PMID: 25154864.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    18. In vivo fluorescence reflectance imaging of protease activity in a mouse model of post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2014 Oct; 22(10):1461-9. Satkunananthan PB, Anderson MJ, De Jesus NM, Haudenschild DR, Ripplinger CM, Christiansen BA. PMID: 25278057.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    19. Cartilage oligomeric matrix protein and its binding partners in the cartilage extracellular matrix: interaction, regulation and role in chondrogenesis. Matrix Biol. 2014 Jul; 37:102-11. Acharya C, Yik JH, Kishore A, Van Dinh V, Di Cesare PE, Haudenschild DR. PMID: 24997222.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    20. Cyclin-dependent kinase 9 inhibition protects cartilage from the catabolic effects of proinflammatory cytokines. Arthritis Rheumatol. 2014 Jun; 66(6):1537-46. Yik JH, Hu Z, Kumari R, Christiansen BA, Haudenschild DR. PMID: 24470357.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    21. The effect of noggin interference in a rabbit posterolateral spinal fusion model. Eur Spine J. 2014 Nov; 23(11):2385-92. Klineberg E, Haudenschild DR, Snow KD, Garitty S, Christiansen BA, Acharya C, Maitra S, Gupta MC. PMID: 24740279.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    22. The Oncogene LRF Stimulates Proliferation of Mesenchymal Stem Cells and Inhibits Their Chondrogenic Differentiation. Cartilage. 2013 Oct; 4(4):329-38. Yik JH, Li H, Acharya C, Kumari R, Fierro F, Haudenschild DR, Nolta J, Di Cesare PE. PMID: 26069677.
      View in: PubMed   Mentions:    Fields:    
    23. Comparison of loading rate-dependent injury modes in a murine model of post-traumatic osteoarthritis. J Orthop Res. 2014 Jan; 32(1):79-88. Lockwood KA, Chu BT, Anderson MJ, Haudenschild DR, Christiansen BA. PMID: 24019199.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    24. Effect of age and cytoskeletal elements on the indentation-dependent mechanical properties of chondrocytes. PLoS One. 2013; 8(4):e61651. Chahine NO, Blanchette C, Thomas CB, Lu J, Haudenschild D, Loots GG. PMID: 23613892.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    25. c-Maf Transcription Factor Regulates ADAMTS-12 Expression in Human Chondrogenic Cells. Cartilage. 2013 Apr; 4(2):177-86. Hong E, Yik J, Amanatullah DF, Di Cesare PE, Haudenschild DR. PMID: 26069660.
      View in: PubMed   Mentions: 1     Fields:    
    26. Cartilage oligomeric matrix protein enhances osteogenesis by directly binding and activating bone morphogenetic protein-2. Bone. 2013 Jul; 55(1):23-35. Ishida K, Acharya C, Christiansen BA, Yik JH, DiCesare PE, Haudenschild DR. PMID: 23528838.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    27. Interactions between FGF21 and BMP-2 in osteogenesis. Biochem Biophys Res Commun. 2013 Mar 22; 432(4):677-82. Ishida K, Haudenschild DR. PMID: 23416071.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    28. Identification of a 3Kbp mechanoresponsive promoter region in the human cartilage oligomeric matrix protein gene. Tissue Eng Part A. 2012 Sep; 18(17-18):1882-9. Amanatullah DF, Lu J, Hecht J, Posey K, Yik J, Di Cesare PE, Haudenschild DR. PMID: 22764748.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    29. The oncogene LRF is a survival factor in chondrosarcoma and contributes to tumor malignancy and drug resistance. Carcinogenesis. 2012 Nov; 33(11):2076-83. Kumari R, Li H, Haudenschild DR, Fierro F, Carlson CS, Overn P, Gupta L, Gupta K, Nolta J, Yik JH, Di Cesare PE. PMID: 22847180.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    30. Musculoskeletal changes following non-invasive knee injury using a novel mouse model of post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2012 Jul; 20(7):773-82. Christiansen BA, Anderson MJ, Lee CA, Williams JC, Yik JH, Haudenschild DR. PMID: 22531459.
      View in: PubMed   Mentions: 53     Fields:    Translation:Animals
    31. Chondrogenic potential and homogeneity of cell populations of donor and recipient cells in a fresh osteochondral allograft: a case report. J Bone Joint Surg Am. 2012 Feb 01; 94(3):e17. Haudenschild DR, Hong E, Hatcher S, Jamali AA. PMID: 22298063.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    32. Enhanced activity of transforming growth factor ß1 (TGF-ß1) bound to cartilage oligomeric matrix protein. J Biol Chem. 2011 Dec 16; 286(50):43250-8. Haudenschild DR, Hong E, Yik JH, Chromy B, Mörgelin M, Snow KD, Acharya C, Takada Y, Di Cesare PE. PMID: 21940632.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    33. Comparative analysis with collagen type II distinguishes cartilage oligomeric matrix protein as a primary TGFß-responsive gene. Osteoarthritis Cartilage. 2011 Oct; 19(10):1246-53. Li H, Haudenschild DR, Posey KL, Hecht JT, Di Cesare PE, Yik JH. PMID: 21843649.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    34. Vimentin contributes to changes in chondrocyte stiffness in osteoarthritis. J Orthop Res. 2011 Jan; 29(1):20-5. Haudenschild DR, Chen J, Pang N, Steklov N, Grogan SP, Lotz MK, D'Lima DD. PMID: 20602472.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    35. Role of c-Maf in Chondrocyte Differentiation: A Review. Cartilage. 2011 Jan; 2(1):27-35. Hong E, Di Cesare PE, Haudenschild DR. PMID: 26069566.
      View in: PubMed   Mentions: 3     Fields:    
    36. Rho kinase-dependent activation of SOX9 in chondrocytes. Arthritis Rheum. 2010 Jan; 62(1):191-200. Haudenschild DR, Chen J, Pang N, Lotz MK, D'Lima DD. PMID: 20039424.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    37. Characterization of the chondrocyte actin cytoskeleton in living three-dimensional culture: response to anabolic and catabolic stimuli. Mol Cell Biomech. 2009 Sep; 6(3):135-44. Haudenschild DR, Chen J, Steklov N, Lotz MK, D'Lima DD. PMID: 19670824.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    38. Rho kinase-dependent CCL20 induced by dynamic compression of human chondrocytes. Arthritis Rheum. 2008 Sep; 58(9):2735-42. Haudenschild DR, Nguyen B, Chen J, D'Lima DD, Lotz MK. PMID: 18759278.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    39. Dynamic compression of chondrocytes induces a Rho kinase-dependent reorganization of the actin cytoskeleton. Biorheology. 2008; 45(3-4):219-28. Haudenschild DR, D'Lima DD, Lotz MK. PMID: 18836226.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    40. Immunolocalization of IL-17A, IL-17B, and their receptors in chondrocytes during fracture healing. J Histochem Cytochem. 2008 Feb; 56(2):89-95. Kokubu T, Haudenschild DR, Moseley TA, Rose L, Reddi AH. PMID: 17827167.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    41. Generation of interleukin-17 receptor-like protein (IL-17RL) in prostate by alternative splicing of RNA. Prostate. 2006 Sep 01; 66(12):1268-74. Haudenschild DR, Curtiss SB, Moseley TA, Reddi AH. PMID: 16688746.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    42. Interleukin-17 receptor-like gene is a novel antiapoptotic gene highly expressed in androgen-independent prostate cancer. Cancer Res. 2006 Jan 01; 66(1):175-83. You Z, Shi XB, DuRaine G, Haudenschild D, Tepper CG, Lo SH, Gandour-Edwards R, de Vere White RW, Reddi AH. PMID: 16397230.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    43. Bone morphogenetic protein (BMP)-6 signaling and BMP antagonist noggin in prostate cancer. Cancer Res. 2004 Nov 15; 64(22):8276-84. Haudenschild DR, Palmer SM, Moseley TA, You Z, Reddi AH. PMID: 15548695.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    44. Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev. 2003 Apr; 14(2):155-74. Moseley TA, Haudenschild DR, Rose L, Reddi AH. PMID: 12651226.
      View in: PubMed   Mentions: 243     Fields:    Translation:Cells
    45. Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer. J Biol Chem. 2002 Feb 08; 277(6):4309-16. Haudenschild D, Moseley T, Rose L, Reddi AH. PMID: 11706037.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    46. Intracranial distribution of the sympathetic system in mice: DiI tracing and immunocytochemical labeling. Anat Rec. 2001 05 01; 263(1):99-111. Maklad A, Quinn T, Fritzsch B. PMID: 11331976.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    47. Expression of a stable articular cartilage phenotype without evidence of hypertrophy by adult human articular chondrocytes in vitro. J Orthop Res. 1998 Mar; 16(2):207-16. Binette F, McQuaid DP, Haudenschild DR, Yaeger PC, McPherson JM, Tubo R. PMID: 9621895.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    48. Cartilage matrix protein: expression patterns in chicken, mouse, and human. Ann N Y Acad Sci. 1996 Jun 08; 785:238-40. Chen Q, Johnson DM, Haudenschild DR, Goetinck PF. PMID: 8702140.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    49. Cartilage matrix protein forms a type II collagen-independent filamentous network: analysis in primary cell cultures with a retrovirus expression system. Mol Biol Cell. 1995 Dec; 6(12):1743-53. Chen Q, Johnson DM, Haudenschild DR, Tondravi MM, Goetinck PF. PMID: 8590802.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    50. Progression and recapitulation of the chondrocyte differentiation program: cartilage matrix protein is a marker for cartilage maturation. Dev Biol. 1995 Nov; 172(1):293-306. Chen Q, Johnson DM, Haudenschild DR, Goetinck PF. PMID: 7589809.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    51. The role of coiled-coil alpha-helices and disulfide bonds in the assembly and stabilization of cartilage matrix protein subunits. A mutational analysis. J Biol Chem. 1995 Sep 29; 270(39):23150-4. Haudenschild DR, Tondravi MM, Hofer U, Chen Q, Goetinck PF. PMID: 7559460.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    52. Link protein is ubiquitously expressed in non-cartilaginous tissues where it enhances and stabilizes the interaction of proteoglycans with hyaluronic acid. J Biol Chem. 1994 Jul 22; 269(29):19116-22. Binette F, Cravens J, Kahoussi B, Haudenschild DR, Goetinck PF. PMID: 8034670.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    53. Cartilage matrix protein binds to collagen and plays a role in collagen fibrillogenesis. Prog Clin Biol Res. 1993; 383B:515-22. Tondravi MM, Winterbottom N, Haudenschild DR, Goetinck PF. PMID: 8115368.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells