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Dominik R Haudenschild

Title(s)Professor, Orthopaedic Surgery
SchoolUniversity of California, Davis
Phone916-734-5015
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    Collapse Research 
    Collapse Research Activities and Funding
    Multivalent Presentation of Growth Factors Regulates Cellular Responses
    NIH/NIAMS R01AR070239Apr 10, 2017 - Jan 31, 2022
    Role: Principal Investigator
    Novel Early Intervention to Prevent Post-Traumatic Osteoarthritis
    NIH/NIAMS R21AR063348Aug 1, 2012 - May 31, 2014
    Role: Principal Investigator
    Identification of Mechanoresponsive Promoter Elements in Chondrogenesis
    NIH/NIAMS R03AR061038Apr 1, 2011 - Mar 31, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wegner AM, Campos NR, Robbins MA, Haddad AF, Cunningham HC, Yik JHN, Christiansen BA, Haudenschild DR. Acute Changes in NADPH Oxidase 4 in Early Post-Traumatic Osteoarthritis. J Orthop Res. 2019 Nov; 37(11):2429-2436. PMID: 31304988.
      View in: PubMed
    2. Tran V, Karsai A, Fong MC, Cai W, Yik JHN, Klineberg E, Haudenschild DR, Liu GY. Label-Free and Direct Visualization of Multivalent Binding of Bone Morphogenetic Protein-2 with Cartilage Oligomeric Matrix Protein. J Phys Chem B. 2019 Jan 10; 123(1):39-46. PMID: 30554512.
      View in: PubMed
    3. Haudenschild DR, Carlson AK, Zignego DL, Yik JHN, Hilmer JK, June RK. Inhibition of early response genes prevents changes in global joint metabolomic profiles in mouse post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2019 Mar; 27(3):504-512. PMID: 30572121.
      View in: PubMed
    4. Shieh AK, Singh SG, Nathe C, Lian E, Haudenschild DR, Nolta JA, Lee CA, Giza E, Kreulen CD. Effects of Micronized Cartilage Matrix on Cartilage Repair in Osteochondral Lesions of the Talus. Cartilage. 2018 Aug 29; 1947603518796125. PMID: 30156865.
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    5. Hu Z, Chen Y, Song L, Yik JHN, Haudenschild DR, Fan S. Flavopiridol Protects Bone Tissue by Attenuating RANKL Induced Osteoclast Formation. Front Pharmacol. 2018; 9:174. PMID: 29773986.
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    6. Grössinger EM, Kang M, Bouchareychas L, Sarin R, Haudenschild DR, Borodinsky LN, Adamopoulos IE. Ca2+-Dependent Regulation of NFATc1 via KCa3.1 in Inflammatory Osteoclastogenesis. J Immunol. 2018 01 15; 200(2):749-757. PMID: 29246953.
      View in: PubMed
    7. Robbins MA, Haudenschild DR, Wegner AM, Klineberg EO. Stem Cells in Spinal Fusion. Global Spine J. 2017 Dec; 7(8):801-810. PMID: 29238646.
      View in: PubMed
    8. Refaat M, Klineberg EO, Fong MC, Garcia TC, Leach JK, Haudenschild DR. Binding to COMP Reduces the BMP2 Dose for Spinal Fusion in a Rat Model. Spine (Phila Pa 1976). 2016 Jul 15; 41(14):E829-36. PMID: 26679888.
      View in: PubMed
    9. Hu Z, Yik JH, Cissell DD, Michelier PV, Athanasiou KA, Haudenschild DR. Inhibition of CDK9 prevents mechanical injury-induced inflammation, apoptosis and matrix degradation in cartilage explants. Eur Cell Mater. 2016; 30:200-9. PMID: 26859911.
      View in: PubMed
    10. Chubinskaya S, Haudenschild D, Gasser S, Stannard J, Krettek C, Borrelli J. Articular Cartilage Injury and Potential Remedies. J Orthop Trauma. 2015 Dec; 29 Suppl 12:S47-52. PMID: 26584267.
      View in: PubMed
    11. Christiansen BA, Guilak F, Lockwood KA, Olson SA, Pitsillides AA, Sandell LJ, Silva MJ, van der Meulen MC, Haudenschild DR. Non-invasive mouse models of post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2015 Oct; 23(10):1627-38. PMID: 26003950.
      View in: PubMed
    12. Fukui T, Tenborg E, Yik JH, Haudenschild DR. In-vitro and in-vivo imaging of MMP activity in cartilage and joint injury. Biochem Biophys Res Commun. 2015 May 08; 460(3):741-6. PMID: 25817731.
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    13. Khorasani MS, Diko S, Hsia AW, Anderson MJ, Genetos DC, Haudenschild DR, Christiansen BA. Effect of alendronate on post-traumatic osteoarthritis induced by anterior cruciate ligament rupture in mice. Arthritis Res Ther. 2015 Feb 16; 17:30. PMID: 25888819.
      View in: PubMed
    14. Haudenschild DR, Eldridge A, Lein PJ, Chromy BA. High abundant protein removal from rodent blood for biomarker discovery. Biochem Biophys Res Commun. 2014 Dec 05; 455(1-2):84-9. PMID: 25445603.
      View in: PubMed
    15. Haudenschild DR, Yik JH. Reply: To PMID 24470357. Arthritis Rheumatol. 2014 Dec; 66(12):3526. PMID: 25154864.
      View in: PubMed
    16. Satkunananthan PB, Anderson MJ, De Jesus NM, Haudenschild DR, Ripplinger CM, Christiansen BA. In vivo fluorescence reflectance imaging of protease activity in a mouse model of post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2014 Oct; 22(10):1461-9. PMID: 25278057.
      View in: PubMed
    17. Acharya C, Yik JH, Kishore A, Van Dinh V, Di Cesare PE, Haudenschild DR. Cartilage oligomeric matrix protein and its binding partners in the cartilage extracellular matrix: interaction, regulation and role in chondrogenesis. Matrix Biol. 2014 Jul; 37:102-11. PMID: 24997222.
      View in: PubMed
    18. Yik JH, Hu Z, Kumari R, Christiansen BA, Haudenschild DR. Cyclin-dependent kinase 9 inhibition protects cartilage from the catabolic effects of proinflammatory cytokines. Arthritis Rheumatol. 2014 Jun; 66(6):1537-46. PMID: 24470357.
      View in: PubMed
    19. Klineberg E, Haudenschild DR, Snow KD, Garitty S, Christiansen BA, Acharya C, Maitra S, Gupta MC. The effect of noggin interference in a rabbit posterolateral spinal fusion model. Eur Spine J. 2014 Nov; 23(11):2385-92. PMID: 24740279.
      View in: PubMed
    20. Yik JH, Li H, Acharya C, Kumari R, Fierro F, Haudenschild DR, Nolta J, Di Cesare PE. The Oncogene LRF Stimulates Proliferation of Mesenchymal Stem Cells and Inhibits Their Chondrogenic Differentiation. Cartilage. 2013 Oct; 4(4):329-38. PMID: 26069677.
      View in: PubMed
    21. Lockwood KA, Chu BT, Anderson MJ, Haudenschild DR, Christiansen BA. Comparison of loading rate-dependent injury modes in a murine model of post-traumatic osteoarthritis. J Orthop Res. 2014 Jan; 32(1):79-88. PMID: 24019199.
      View in: PubMed
    22. Chahine NO, Blanchette C, Thomas CB, Lu J, Haudenschild D, Loots GG. Effect of age and cytoskeletal elements on the indentation-dependent mechanical properties of chondrocytes. PLoS One. 2013; 8(4):e61651. PMID: 23613892.
      View in: PubMed
    23. Hong E, Yik J, Amanatullah DF, Di Cesare PE, Haudenschild DR. c-Maf Transcription Factor Regulates ADAMTS-12 Expression in Human Chondrogenic Cells. Cartilage. 2013 Apr; 4(2):177-86. PMID: 26069660.
      View in: PubMed
    24. Ishida K, Acharya C, Christiansen BA, Yik JH, DiCesare PE, Haudenschild DR. Cartilage oligomeric matrix protein enhances osteogenesis by directly binding and activating bone morphogenetic protein-2. Bone. 2013 Jul; 55(1):23-35. PMID: 23528838.
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    25. Ishida K, Haudenschild DR. Interactions between FGF21 and BMP-2 in osteogenesis. Biochem Biophys Res Commun. 2013 Mar 22; 432(4):677-82. PMID: 23416071.
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    26. Amanatullah DF, Lu J, Hecht J, Posey K, Yik J, Di Cesare PE, Haudenschild DR. Identification of a 3Kbp mechanoresponsive promoter region in the human cartilage oligomeric matrix protein gene. Tissue Eng Part A. 2012 Sep; 18(17-18):1882-9. PMID: 22764748.
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    27. Kumari R, Li H, Haudenschild DR, Fierro F, Carlson CS, Overn P, Gupta L, Gupta K, Nolta J, Yik JH, Di Cesare PE. The oncogene LRF is a survival factor in chondrosarcoma and contributes to tumor malignancy and drug resistance. Carcinogenesis. 2012 Nov; 33(11):2076-83. PMID: 22847180.
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    28. Christiansen BA, Anderson MJ, Lee CA, Williams JC, Yik JH, Haudenschild DR. Musculoskeletal changes following non-invasive knee injury using a novel mouse model of post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2012 Jul; 20(7):773-82. PMID: 22531459.
      View in: PubMed
    29. Haudenschild DR, Hong E, Hatcher S, Jamali AA. Chondrogenic potential and homogeneity of cell populations of donor and recipient cells in a fresh osteochondral allograft: a case report. J Bone Joint Surg Am. 2012 Feb 01; 94(3):e17. PMID: 22298063.
      View in: PubMed
    30. Haudenschild DR, Hong E, Yik JH, Chromy B, Mörgelin M, Snow KD, Acharya C, Takada Y, Di Cesare PE. Enhanced activity of transforming growth factor ß1 (TGF-ß1) bound to cartilage oligomeric matrix protein. J Biol Chem. 2011 Dec 16; 286(50):43250-8. PMID: 21940632.
      View in: PubMed
    31. Li H, Haudenschild DR, Posey KL, Hecht JT, Di Cesare PE, Yik JH. Comparative analysis with collagen type II distinguishes cartilage oligomeric matrix protein as a primary TGFß-responsive gene. Osteoarthritis Cartilage. 2011 Oct; 19(10):1246-53. PMID: 21843649.
      View in: PubMed
    32. Haudenschild DR, Chen J, Pang N, Steklov N, Grogan SP, Lotz MK, D'Lima DD. Vimentin contributes to changes in chondrocyte stiffness in osteoarthritis. J Orthop Res. 2011 Jan; 29(1):20-5. PMID: 20602472.
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    33. Hong E, Di Cesare PE, Haudenschild DR. Role of c-Maf in Chondrocyte Differentiation: A Review. Cartilage. 2011 Jan; 2(1):27-35. PMID: 26069566.
      View in: PubMed
    34. Haudenschild DR, Chen J, Pang N, Lotz MK, D'Lima DD. Rho kinase-dependent activation of SOX9 in chondrocytes. Arthritis Rheum. 2010 Jan; 62(1):191-200. PMID: 20039424.
      View in: PubMed
    35. Haudenschild DR, Chen J, Steklov N, Lotz MK, D'Lima DD. Characterization of the chondrocyte actin cytoskeleton in living three-dimensional culture: response to anabolic and catabolic stimuli. Mol Cell Biomech. 2009 Sep; 6(3):135-44. PMID: 19670824.
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    36. Haudenschild DR, Nguyen B, Chen J, D'Lima DD, Lotz MK. Rho kinase-dependent CCL20 induced by dynamic compression of human chondrocytes. Arthritis Rheum. 2008 Sep; 58(9):2735-42. PMID: 18759278.
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    37. Haudenschild DR, D'Lima DD, Lotz MK. Dynamic compression of chondrocytes induces a Rho kinase-dependent reorganization of the actin cytoskeleton. Biorheology. 2008; 45(3-4):219-28. PMID: 18836226.
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    38. Kokubu T, Haudenschild DR, Moseley TA, Rose L, Reddi AH. Immunolocalization of IL-17A, IL-17B, and their receptors in chondrocytes during fracture healing. J Histochem Cytochem. 2008 Feb; 56(2):89-95. PMID: 17827167.
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    39. Haudenschild DR, Curtiss SB, Moseley TA, Reddi AH. Generation of interleukin-17 receptor-like protein (IL-17RL) in prostate by alternative splicing of RNA. Prostate. 2006 Sep 01; 66(12):1268-74. PMID: 16688746.
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    40. You Z, Shi XB, DuRaine G, Haudenschild D, Tepper CG, Lo SH, Gandour-Edwards R, de Vere White RW, Reddi AH. Interleukin-17 receptor-like gene is a novel antiapoptotic gene highly expressed in androgen-independent prostate cancer. Cancer Res. 2006 Jan 01; 66(1):175-83. PMID: 16397230.
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    41. Haudenschild DR, Palmer SM, Moseley TA, You Z, Reddi AH. Bone morphogenetic protein (BMP)-6 signaling and BMP antagonist noggin in prostate cancer. Cancer Res. 2004 Nov 15; 64(22):8276-84. PMID: 15548695.
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    42. Moseley TA, Haudenschild DR, Rose L, Reddi AH. Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev. 2003 Apr; 14(2):155-74. PMID: 12651226.
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    43. Haudenschild D, Moseley T, Rose L, Reddi AH. Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer. J Biol Chem. 2002 Feb 08; 277(6):4309-16. PMID: 11706037.
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    44. Maklad A, Quinn T, Fritzsch B. Intracranial distribution of the sympathetic system in mice: DiI tracing and immunocytochemical labeling. Anat Rec. 2001 05 01; 263(1):99-111. PMID: 11331976.
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    45. Binette F, McQuaid DP, Haudenschild DR, Yaeger PC, McPherson JM, Tubo R. Expression of a stable articular cartilage phenotype without evidence of hypertrophy by adult human articular chondrocytes in vitro. J Orthop Res. 1998 Mar; 16(2):207-16. PMID: 9621895.
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    46. Chen Q, Johnson DM, Haudenschild DR, Goetinck PF. Cartilage matrix protein: expression patterns in chicken, mouse, and human. Ann N Y Acad Sci. 1996 Jun 08; 785:238-40. PMID: 8702140.
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    47. Chen Q, Johnson DM, Haudenschild DR, Tondravi MM, Goetinck PF. Cartilage matrix protein forms a type II collagen-independent filamentous network: analysis in primary cell cultures with a retrovirus expression system. Mol Biol Cell. 1995 Dec; 6(12):1743-53. PMID: 8590802.
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    48. Chen Q, Johnson DM, Haudenschild DR, Goetinck PF. Progression and recapitulation of the chondrocyte differentiation program: cartilage matrix protein is a marker for cartilage maturation. Dev Biol. 1995 Nov; 172(1):293-306. PMID: 7589809.
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    49. Haudenschild DR, Tondravi MM, Hofer U, Chen Q, Goetinck PF. The role of coiled-coil alpha-helices and disulfide bonds in the assembly and stabilization of cartilage matrix protein subunits. A mutational analysis. J Biol Chem. 1995 Sep 29; 270(39):23150-4. PMID: 7559460.
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    50. Binette F, Cravens J, Kahoussi B, Haudenschild DR, Goetinck PF. Link protein is ubiquitously expressed in non-cartilaginous tissues where it enhances and stabilizes the interaction of proteoglycans with hyaluronic acid. J Biol Chem. 1994 Jul 22; 269(29):19116-22. PMID: 8034670.
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    51. Tondravi MM, Winterbottom N, Haudenschild DR, Goetinck PF. Cartilage matrix protein binds to collagen and plays a role in collagen fibrillogenesis. Prog Clin Biol Res. 1993; 383B:515-22. PMID: 8115368.
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