Damian C Genetos

Title(s)Associate Professor, SCHOOL OF VETERINARY MEDICINE
SchoolUniversity of California, Davis
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    Collapse Research 
    Collapse Research Activities and Funding
    HIFs in osteocytes
    NIH/NIAMS R01AR073772Apr 1, 2019 - Feb 29, 2024
    Role: Co-Principal Investigator
    Integration of TGFb-ALK5 on Wnt signaling and mechanotransduction in bone
    NIH/NIAMS R01AR064255Jul 1, 2013 - Jun 30, 2018
    Role: Principal Investigator
    Regulation of sclerostin expression by hypoxia: A proposed mechanism to explain h
    NIH/NIAMS R03AR057547Apr 1, 2010 - Nov 30, 2013
    Role: Principal Investigator
    Mechanisms of Cystic Fibrosis-induced Osteoporosis
    NIH/NIAMS F32AR054226Oct 1, 2008 - Sep 30, 2011
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Pusceddu MM, Stokes PJ, Wong A, Gareau MG, Genetos DC. Sexually-dimorphic influence of neonatal antibiotics on bone. J Orthop Res. 2019 Jun 22. PMID: 31228216.
      View in: PubMed
    2. Yellowley CE, Genetos DC. Hypoxia Signaling in the Skeleton: Implications for Bone Health. Curr Osteoporos Rep. 2019 Feb; 17(1):26-35. PMID: 30725321.
      View in: PubMed
    3. Loots GG, Robling AG, Chang JC, Murugesh DK, Bajwa J, Carlisle C, Manilay JO, Wong A, Yellowley CE, Genetos DC. Vhl deficiency in osteocytes produces high bone mass and hematopoietic defects. Bone. 2018 11; 116:307-314. PMID: 30172741.
      View in: PubMed
    4. Donahue HJ, Qu RW, Genetos DC. Joint diseases: from connexins to gap junctions. Nat Rev Rheumatol. 2017 Dec 19; 14(1):42-51. PMID: 29255213.
      View in: PubMed
    5. Heffner MA, Genetos DC, Christiansen BA. Bone adaptation to mechanical loading in a mouse model of reduced peripheral sensory nerve function. PLoS One. 2017; 12(10):e0187354. PMID: 29088267.
      View in: PubMed
    6. Murphy KC, Hung BP, Browne-Bourne S, Zhou D, Yeung J, Genetos DC, Leach JK. Measurement of oxygen tension within mesenchymal stem cell spheroids. J R Soc Interface. 2017 02; 14(127). PMID: 28179546.
      View in: PubMed
    7. Robling AG, Kang KS, Bullock WA, Foster WH, Murugesh D, Loots GG, Genetos DC. Sost, independent of the non-coding enhancer ECR5, is required for bone mechanoadaptation. Bone. 2016 11; 92:180-188. PMID: 27601226.
      View in: PubMed
    8. Wong A, Loots GG, Yellowley CE, Dosé AC, Genetos DC. Parathyroid hormone regulation of hypoxia-inducible factor signaling in osteoblastic cells. Bone. 2015 Dec; 81:97-103. PMID: 26151122.
      View in: PubMed
    9. Genetos DC, Wong A, Weber TJ, Karin NJ, Yellowley CE. Impaired osteoblast differentiation in annexin A2- and -A5-deficient cells. PLoS One. 2014; 9(9):e107482. PMID: 25222280.
      View in: PubMed
    10. Chahine NO, Collette NM, Thomas CB, Genetos DC, Loots GG. Nanocomposite scaffold for chondrocyte growth and cartilage tissue engineering: effects of carbon nanotube surface functionalization. Tissue Eng Part A. 2014 Sep; 20(17-18):2305-15. PMID: 24593020; PMCID: PMC4172384.
    11. Binder BY, Genetos DC, Leach JK. Lysophosphatidic acid protects human mesenchymal stromal cells from differentiation-dependent vulnerability to apoptosis. Tissue Eng Part A. 2014 Apr; 20(7-8):1156-64. PMID: 24131310; PMCID: PMC3993074.
    12. Donahue HJ, Genetos DC. Genomic approaches in breast cancer research. Brief Funct Genomics. 2013 Sep; 12(5):391-6. PMID: 23788797; PMCID: PMC3776566.
    13. Collette NM, Genetos DC, Economides AN, Xie L, Shahnazari M, Yao W, Lane NE, Harland RM, Loots GG. Targeted deletion of Sost distal enhancer increases bone formation and bone mass. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14092-7. PMID: 22886088; PMCID: PMC3435175.
    14. Genetos DC, Zhou Z, Li Z, Donahue HJ. Age-related changes in gap junctional intercellular communication in osteoblastic cells. J Orthop Res. 2012 Dec; 30(12):1979-84. PMID: 22696456; PMCID: PMC3640546.
    15. Morales-Hernandez DG, Genetos DC, Working DM, Murphy KC, Leach JK. Ceramic identity contributes to mechanical properties and osteoblast behavior on macroporous composite scaffolds. J Funct Biomater. 2012 May 23; 3(2):382-97. PMID: 24955539; PMCID: PMC4047943.
    16. Toupadakis CA, Wong A, Genetos DC, Chung DJ, Murugesh D, Anderson MJ, Loots GG, Christiansen BA, Kapatkin AS, Yellowley CE. Long-term administration of AMD3100, an antagonist of SDF-1/CXCR4 signaling, alters fracture repair. J Orthop Res. 2012 Nov; 30(11):1853-9. PMID: 22592891.
      View in: PubMed
    17. Hoch AI, Binder BY, Genetos DC, Leach JK. Differentiation-dependent secretion of proangiogenic factors by mesenchymal stem cells. PLoS One. 2012; 7(4):e35579. PMID: 22536411; PMCID: PMC3334972.
    18. Loots GG, Keller H, Leupin O, Murugesh D, Collette NM, Genetos DC. TGF-ß regulates sclerostin expression via the ECR5 enhancer. Bone. 2012 Mar; 50(3):663-9. PMID: 22155511; PMCID: PMC3278543.
    19. Morgan JM, Wong A, Yellowley CE, Genetos DC. Regulation of tenascin expression in bone. J Cell Biochem. 2011 Nov; 112(11):3354-63. PMID: 21751239; PMCID: PMC3196820.
    20. Watari S, Hayashi K, Wood JA, Russell P, Nealey PF, Murphy CJ, Genetos DC. Modulation of osteogenic differentiation in hMSCs cells by submicron topographically-patterned ridges and grooves. Biomaterials. 2012 Jan; 33(1):128-36. PMID: 21982295; PMCID: PMC3208761.
    21. Raheja LF, Genetos DC, Wong A, Yellowley CE. Hypoxic regulation of mesenchymal stem cell migration: the role of RhoA and HIF-1a. Cell Biol Int. 2011 Oct; 35(10):981-9. PMID: 21574962.
      View in: PubMed
    22. Davis HE, Case EM, Miller SL, Genetos DC, Leach JK. Osteogenic response to BMP-2 of hMSCs grown on apatite-coated scaffolds. Biotechnol Bioeng. 2011 Nov; 108(11):2727-35. PMID: 21656707; PMCID: PMC3178749.
    23. Genetos DC, Yellowley CE, Loots GG. Prostaglandin E2 signals through PTGER2 to regulate sclerostin expression. PLoS One. 2011 Mar 16; 6(3):e17772. PMID: 21436889; PMCID: PMC3059227.
    24. Genetos DC, Karin NJ, Geist DJ, Donahue HJ, Duncan RL. Purinergic signaling is required for fluid shear stress-induced NF-?B translocation in osteoblasts. Exp Cell Res. 2011 Apr 01; 317(6):737-44. PMID: 21237152; PMCID: PMC3049820.
    25. Morgan JM, Wong A, Genetos DC, Yellowley CE. Src is sufficient, but not necessary, for osteopontin induction in osteoblasts. Biorheology. 2011; 48(1):65-74. PMID: 21515937.
      View in: PubMed
    26. Toupadakis CA, Wong A, Genetos DC, Cheung WK, Borjesson DL, Ferraro GL, Galuppo LD, Leach JK, Owens SD, Yellowley CE. Comparison of the osteogenic potential of equine mesenchymal stem cells from bone marrow, adipose tissue, umbilical cord blood, and umbilical cord tissue. Am J Vet Res. 2010 Oct; 71(10):1237-45. PMID: 20919913.
      View in: PubMed
    27. Genetos DC, Wong A, Watari S, Yellowley CE. Hypoxia increases Annexin A2 expression in osteoblastic cells via VEGF and ERK. Bone. 2010 Dec; 47(6):1013-9. PMID: 20817051; PMCID: PMC4420171.
    28. Genetos DC, Toupadakis CA, Raheja LF, Wong A, Papanicolaou SE, Fyhrie DP, Loots GG, Yellowley CE. Hypoxia decreases sclerostin expression and increases Wnt signaling in osteoblasts. J Cell Biochem. 2010 May 15; 110(2):457-67. PMID: 20336693; PMCID: PMC2881162.
    29. He J, Genetos DC, Yellowley CE, Leach JK. Oxygen tension differentially influences osteogenic differentiation of human adipose stem cells in 2D and 3D cultures. J Cell Biochem. 2010 May; 110(1):87-96. PMID: 20213746.
      View in: PubMed
    30. Collette NM, Genetos DC, Murugesh D, Harland RM, Loots GG. Genetic evidence that SOST inhibits WNT signaling in the limb. Dev Biol. 2010 Jun 15; 342(2):169-79. PMID: 20359476; PMCID: PMC2896299.
    31. Genetos DC, Rao RR, Vidal MA. Betacellulin inhibits osteogenic differentiation and stimulates proliferation through HIF-1alpha. Cell Tissue Res. 2010 Apr; 340(1):81-9. PMID: 20165885; PMCID: PMC2847694.
    32. Genetos DC, Cheung WK, Decaris ML, Leach JK. Oxygen tension modulates neurite outgrowth in PC12 cells through a mechanism involving HIF and VEGF. J Mol Neurosci. 2010 Mar; 40(3):360-6. PMID: 20107925; PMCID: PMC2825316.
    33. He J, Genetos DC, Leach JK. Osteogenesis and trophic factor secretion are influenced by the composition of hydroxyapatite/poly(lactide-co-glycolide) composite scaffolds. Tissue Eng Part A. 2010 Jan; 16(1):127-37. PMID: 19642853; PMCID: PMC2811060.
    34. Raheja LF, Genetos DC, Yellowley CE. The effect of oxygen tension on the long-term osteogenic differentiation and MMP/TIMP expression of human mesenchymal stem cells. Cells Tissues Organs. 2010; 191(3):175-84. PMID: 19690399.
      View in: PubMed
    35. Lee CM, Genetos DC, Wong A, Yellowley CE. Prostaglandin expression profile in hypoxic osteoblastic cells. J Bone Miner Metab. 2010; 28(1):8-16. PMID: 19471853.
      View in: PubMed
    36. Genetos DC, Lee CM, Wong A, Yellowley CE. HIF-1alpha regulates hypoxia-induced EP1 expression in osteoblastic cells. J Cell Biochem. 2009 May 15; 107(2):233-9. PMID: 19277991; PMCID: PMC4410710.
    37. Papanicolaou SE, Phipps RJ, Fyhrie DP, Genetos DC. Modulation of sclerostin expression by mechanical loading and bone morphogenetic proteins in osteogenic cells. Biorheology. 2009; 46(5):389-99. PMID: 19940355.
      View in: PubMed
    38. Raheja LF, Genetos DC, Yellowley CE. Hypoxic osteocytes recruit human MSCs through an OPN/CD44-mediated pathway. Biochem Biophys Res Commun. 2008 Feb 22; 366(4):1061-6. PMID: 18155656.
      View in: PubMed
    39. Liu D, Genetos DC, Shao Y, Geist DJ, Li J, Ke HZ, Turner CH, Duncan RL. Activation of extracellular-signal regulated kinase (ERK1/2) by fluid shear is Ca(2+)- and ATP-dependent in MC3T3-E1 osteoblasts. Bone. 2008 Apr; 42(4):644-52. PMID: 18291742; PMCID: PMC2937351.
    40. Waters KM, Tan R, Genetos DC, Verma S, Yellowley CE, Karin NJ. DNA microarray analysis reveals a role for lysophosphatidic acid in the regulation of anti-inflammatory genes in MC3T3-E1 cells. Bone. 2007 Nov; 41(5):833-41. PMID: 17719864.
      View in: PubMed
    41. Genetos DC, Kephart CJ, Zhang Y, Yellowley CE, Donahue HJ. Oscillating fluid flow activation of gap junction hemichannels induces ATP release from MLO-Y4 osteocytes. J Cell Physiol. 2007 Jul; 212(1):207-14. PMID: 17301958; PMCID: PMC2929812.
    42. Lee CM, Genetos DC, You Z, Yellowley CE. Hypoxia regulates PGE(2) release and EP1 receptor expression in osteoblastic cells. J Cell Physiol. 2007 Jul; 212(1):182-8. PMID: 17370287; PMCID: PMC2929130.
    43. Riddle RC, Taylor AF, Genetos DC, Donahue HJ. MAP kinase and calcium signaling mediate fluid flow-induced human mesenchymal stem cell proliferation. Am J Physiol Cell Physiol. 2006 Mar; 290(3):C776-84. PMID: 16267109.
      View in: PubMed
    44. Genetos DC, Geist DJ, Liu D, Donahue HJ, Duncan RL. Fluid shear-induced ATP secretion mediates prostaglandin release in MC3T3-E1 osteoblasts. J Bone Miner Res. 2005 Jan; 20(1):41-9. PMID: 15619668; PMCID: PMC2929123.
    45. Chen NX, Geist DJ, Genetos DC, Pavalko FM, Duncan RL. Fluid shear-induced NFkappaB translocation in osteoblasts is mediated by intracellular calcium release. Bone. 2003 Sep; 33(3):399-410. PMID: 13678782.
      View in: PubMed