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Hypoxia-Inducible Factor-2a Signaling in the Skeletal System. JBMR Plus. 2023 Apr; 7(4):e10733.
Mendoza SV, Genetos DC, Yellowley CE. PMID: 37065626; PMCID: PMC10097641.
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PubMed Mentions:
1
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Degradation-Resistant Hypoxia Inducible Factor-2a in Murine Osteocytes Promotes a High Bone Mass Phenotype. JBMR Plus. 2023 Apr; 7(4):e10724.
Mendoza SV, Murugesh DK, Christiansen BA, Genetos ZO, Loots GG, Genetos DC, Yellowley CE. PMID: 37065633; PMCID: PMC10097640.
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PubMed Mentions:
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Improving Bone Health by Optimizing the Anabolic Action of Wnt Inhibitor Multitargeting. JBMR Plus. 2021 May; 5(5):e10462.
Choi RB, Bullock WA, Hoggatt AM, Loots GG, Genetos DC, Robling AG. PMID: 33977198; PMCID: PMC8101614.
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PubMed Mentions:
2
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The Role of Nerves in Skeletal Development, Adaptation, and Aging. Front Endocrinol (Lausanne). 2020; 11:646.
Tomlinson RE, Christiansen BA, Giannone AA, Genetos DC. PMID: 33071963; PMCID: PMC7538664.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimals
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Osteogenic preconditioning in perfusion bioreactors improves vascularization and bone formation by human bone marrow aspirates. Sci Adv. 2020 02; 6(7):eaay2387.
Harvestine JN, Gonzalez-Fernandez T, Sebastian A, Hum NR, Genetos DC, Loots GG, Leach JK. PMID: 32095526; PMCID: PMC7015678.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Sexually Dimorphic Influence of Neonatal Antibiotics on Bone. J Orthop Res. 2019 10; 37(10):2122-2129.
Pusceddu MM, Stokes PJ, Wong A, Gareau MG, Genetos DC. PMID: 31228216; PMCID: PMC6886746.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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Hypoxia Signaling in the Skeleton: Implications for Bone Health. Curr Osteoporos Rep. 2019 02; 17(1):26-35.
Yellowley CE, Genetos DC. PMID: 30725321; PMCID: PMC6653634.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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Vhl deficiency in osteocytes produces high bone mass and hematopoietic defects. Bone. 2018 11; 116:307-314.
Loots GG, Robling AG, Chang JC, Murugesh DK, Bajwa J, Carlisle C, Manilay JO, Wong A, Yellowley CE, Genetos DC. PMID: 30172741.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Joint diseases: from connexins to gap junctions. Nat Rev Rheumatol. 2017 Dec 19; 14(1):42-51.
Donahue HJ, Qu RW, Genetos DC. PMID: 29255213.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Bone adaptation to mechanical loading in a mouse model of reduced peripheral sensory nerve function. PLoS One. 2017; 12(10):e0187354.
Heffner MA, Genetos DC, Christiansen BA. PMID: 29088267; PMCID: PMC5663494.
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PubMed Mentions:
10 Fields:
Translation:
Animals
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Measurement of oxygen tension within mesenchymal stem cell spheroids. J R Soc Interface. 2017 02; 14(127).
Murphy KC, Hung BP, Browne-Bourne S, Zhou D, Yeung J, Genetos DC, Leach JK. PMID: 28179546; PMCID: PMC5332570.
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PubMed Mentions:
40 Fields:
Translation:
HumansCells
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Sost, independent of the non-coding enhancer ECR5, is required for bone mechanoadaptation. Bone. 2016 11; 92:180-188.
Robling AG, Kang KS, Bullock WA, Foster WH, Murugesh D, Loots GG, Genetos DC. PMID: 27601226; PMCID: PMC6673653.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Parathyroid hormone regulation of hypoxia-inducible factor signaling in osteoblastic cells. Bone. 2015 Dec; 81:97-103.
Wong A, Loots GG, Yellowley CE, Dosé AC, Genetos DC. PMID: 26151122; PMCID: PMC4641015.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Effect of alendronate on post-traumatic osteoarthritis induced by anterior cruciate ligament rupture in mice. Arthritis Res Ther. 2015 Feb 16; 17:30.
Khorasani MS, Diko S, Hsia AW, Anderson MJ, Genetos DC, Haudenschild DR, Christiansen BA. PMID: 25888819; PMCID: PMC4355375.
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PubMed Mentions:
34 Fields:
Translation:
Animals
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Impaired osteoblast differentiation in annexin A2- and -A5-deficient cells. PLoS One. 2014; 9(9):e107482.
Genetos DC, Wong A, Weber TJ, Karin NJ, Yellowley CE. PMID: 25222280; PMCID: PMC4164658.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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Nanocomposite scaffold for chondrocyte growth and cartilage tissue engineering: effects of carbon nanotube surface functionalization. Tissue Eng Part A. 2014 Sep; 20(17-18):2305-15.
Chahine NO, Collette NM, Thomas CB, Genetos DC, Loots GG. PMID: 24593020; PMCID: PMC4172384.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Altered bone development in a mouse model of peripheral sensory nerve inactivation. J Musculoskelet Neuronal Interact. 2014 Mar; 14(1):1-9.
Heffner MA, Anderson MJ, Yeh GC, Genetos DC, Christiansen BA. PMID: 24583535; PMCID: PMC4123540.
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PubMed Mentions:
14 Fields:
Translation:
Animals
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Lysophosphatidic acid protects human mesenchymal stromal cells from differentiation-dependent vulnerability to apoptosis. Tissue Eng Part A. 2014 Apr; 20(7-8):1156-64.
Binder BY, Genetos DC, Leach JK. PMID: 24131310; PMCID: PMC3993074.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Genomic approaches in breast cancer research. Brief Funct Genomics. 2013 Sep; 12(5):391-6.
Donahue HJ, Genetos DC. PMID: 23788797; PMCID: PMC3776566.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Targeted deletion of Sost distal enhancer increases bone formation and bone mass. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14092-7.
Collette NM, Genetos DC, Economides AN, Xie L, Shahnazari M, Yao W, Lane NE, Harland RM, Loots GG. PMID: 22886088; PMCID: PMC3435175.
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PubMed Mentions:
69 Fields:
Translation:
AnimalsCells
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Age-related changes in gap junctional intercellular communication in osteoblastic cells. J Orthop Res. 2012 Dec; 30(12):1979-84.
Genetos DC, Zhou Z, Li Z, Donahue HJ. PMID: 22696456; PMCID: PMC3640546.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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Ceramic identity contributes to mechanical properties and osteoblast behavior on macroporous composite scaffolds. J Funct Biomater. 2012 May 23; 3(2):382-97.
Morales-Hernandez DG, Genetos DC, Working DM, Murphy KC, Leach JK. PMID: 24955539; PMCID: PMC4047943.
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PubMed Mentions:
3
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Long-term administration of AMD3100, an antagonist of SDF-1/CXCR4 signaling, alters fracture repair. J Orthop Res. 2012 Nov; 30(11):1853-9.
Toupadakis CA, Wong A, Genetos DC, Chung DJ, Murugesh D, Anderson MJ, Loots GG, Christiansen BA, Kapatkin AS, Yellowley CE. PMID: 22592891; PMCID: PMC3704138.
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PubMed Mentions:
37 Fields:
Translation:
Animals
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Differentiation-dependent secretion of proangiogenic factors by mesenchymal stem cells. PLoS One. 2012; 7(4):e35579.
Hoch AI, Binder BY, Genetos DC, Leach JK. PMID: 22536411; PMCID: PMC3334972.
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PubMed Mentions:
66 Fields:
Translation:
HumansCells
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TGF-β regulates sclerostin expression via the ECR5 enhancer. Bone. 2012 Mar; 50(3):663-9.
Loots GG, Keller H, Leupin O, Murugesh D, Collette NM, Genetos DC. PMID: 22155511; PMCID: PMC3278543.
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PubMed Mentions:
35 Fields:
Translation:
AnimalsCells
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Regulation of tenascin expression in bone. J Cell Biochem. 2011 Nov; 112(11):3354-63.
Morgan JM, Wong A, Yellowley CE, Genetos DC. PMID: 21751239; PMCID: PMC3196820.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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Modulation of osteogenic differentiation in hMSCs cells by submicron topographically-patterned ridges and grooves. Biomaterials. 2012 Jan; 33(1):128-36.
Watari S, Hayashi K, Wood JA, Russell P, Nealey PF, Murphy CJ, Genetos DC. PMID: 21982295; PMCID: PMC3208761.
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PubMed Mentions:
45 Fields:
Translation:
HumansCells
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Hypoxic regulation of mesenchymal stem cell migration: the role of RhoA and HIF-1α. Cell Biol Int. 2011 Oct; 35(10):981-9.
Raheja LF, Genetos DC, Wong A, Yellowley CE. PMID: 21574962.
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PubMed Mentions:
32 Fields:
Translation:
HumansCells
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Osteogenic response to BMP-2 of hMSCs grown on apatite-coated scaffolds. Biotechnol Bioeng. 2011 Nov; 108(11):2727-35.
Davis HE, Case EM, Miller SL, Genetos DC, Leach JK. PMID: 21656707; PMCID: PMC3178749.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Prostaglandin E2 signals through PTGER2 to regulate sclerostin expression. PLoS One. 2011 Mar 16; 6(3):e17772.
Genetos DC, Yellowley CE, Loots GG. PMID: 21436889; PMCID: PMC3059227.
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PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
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Purinergic signaling is required for fluid shear stress-induced NF-κB translocation in osteoblasts. Exp Cell Res. 2011 Apr 01; 317(6):737-44.
Genetos DC, Karin NJ, Geist DJ, Donahue HJ, Duncan RL. PMID: 21237152; PMCID: PMC3049820.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Src is sufficient, but not necessary, for osteopontin induction in osteoblasts. Biorheology. 2011; 48(1):65-74.
Morgan JM, Wong A, Genetos DC, Yellowley CE. PMID: 21515937.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Comparison of the osteogenic potential of equine mesenchymal stem cells from bone marrow, adipose tissue, umbilical cord blood, and umbilical cord tissue. Am J Vet Res. 2010 Oct; 71(10):1237-45.
Toupadakis CA, Wong A, Genetos DC, Cheung WK, Borjesson DL, Ferraro GL, Galuppo LD, Leach JK, Owens SD, Yellowley CE. PMID: 20919913.
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PubMed Mentions:
54 Fields:
Translation:
AnimalsCells
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Hypoxia increases Annexin A2 expression in osteoblastic cells via VEGF and ERK. Bone. 2010 Dec; 47(6):1013-9.
Genetos DC, Wong A, Watari S, Yellowley CE. PMID: 20817051; PMCID: PMC4420171.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Hypoxia decreases sclerostin expression and increases Wnt signaling in osteoblasts. J Cell Biochem. 2010 May 15; 110(2):457-67.
Genetos DC, Toupadakis CA, Raheja LF, Wong A, Papanicolaou SE, Fyhrie DP, Loots GG, Yellowley CE. PMID: 20336693; PMCID: PMC2881162.
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PubMed Mentions:
62 Fields:
Translation:
HumansCells
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Oxygen tension differentially influences osteogenic differentiation of human adipose stem cells in 2D and 3D cultures. J Cell Biochem. 2010 May; 110(1):87-96.
He J, Genetos DC, Yellowley CE, Leach JK. PMID: 20213746.
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PubMed Mentions:
28 Fields:
Translation:
HumansCells
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Neutrophils exposed to A. phagocytophilum under shear stress fail to fully activate, polarize, and transmigrate across inflamed endothelium. Am J Physiol Cell Physiol. 2010 Jul; 299(1):C87-96.
Schaff UY, Trott KA, Chase S, Tam K, Johns JL, Carlyon JA, Genetos DC, Walker NJ, Simon SI, Borjesson DL. PMID: 20392928; PMCID: PMC2904253.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Genetic evidence that SOST inhibits WNT signaling in the limb. Dev Biol. 2010 Jun 15; 342(2):169-79.
Collette NM, Genetos DC, Murugesh D, Harland RM, Loots GG. PMID: 20359476; PMCID: PMC2896299.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimals
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Betacellulin inhibits osteogenic differentiation and stimulates proliferation through HIF-1alpha. Cell Tissue Res. 2010 Apr; 340(1):81-9.
Genetos DC, Rao RR, Vidal MA. PMID: 20165885; PMCID: PMC2847694.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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Oxygen tension modulates neurite outgrowth in PC12 cells through a mechanism involving HIF and VEGF. J Mol Neurosci. 2010 Mar; 40(3):360-6.
Genetos DC, Cheung WK, Decaris ML, Leach JK. PMID: 20107925; PMCID: PMC2825316.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Osteogenesis and trophic factor secretion are influenced by the composition of hydroxyapatite/poly(lactide-co-glycolide) composite scaffolds. Tissue Eng Part A. 2010 Jan; 16(1):127-37.
He J, Genetos DC, Leach JK. PMID: 19642853; PMCID: PMC2811060.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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The effect of oxygen tension on the long-term osteogenic differentiation and MMP/TIMP expression of human mesenchymal stem cells. Cells Tissues Organs. 2010; 191(3):175-84.
Raheja LF, Genetos DC, Yellowley CE. PMID: 19690399.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Prostaglandin expression profile in hypoxic osteoblastic cells. J Bone Miner Metab. 2010; 28(1):8-16.
Lee CM, Genetos DC, Wong A, Yellowley CE. PMID: 19471853.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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HIF-1alpha regulates hypoxia-induced EP1 expression in osteoblastic cells. J Cell Biochem. 2009 May 15; 107(2):233-9.
Genetos DC, Lee CM, Wong A, Yellowley CE. PMID: 19277991; PMCID: PMC4410710.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Modulation of sclerostin expression by mechanical loading and bone morphogenetic proteins in osteogenic cells. Biorheology. 2009; 46(5):389-99.
Papanicolaou SE, Phipps RJ, Fyhrie DP, Genetos DC. PMID: 19940355.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Hypoxic osteocytes recruit human MSCs through an OPN/CD44-mediated pathway. Biochem Biophys Res Commun. 2008 Feb 22; 366(4):1061-6.
Raheja LF, Genetos DC, Yellowley CE. PMID: 18155656.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Activation of extracellular-signal regulated kinase (ERK1/2) by fluid shear is Ca(2+)- and ATP-dependent in MC3T3-E1 osteoblasts. Bone. 2008 Apr; 42(4):644-52.
Liu D, Genetos DC, Shao Y, Geist DJ, Li J, Ke HZ, Turner CH, Duncan RL. PMID: 18291742; PMCID: PMC2937351.
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PubMed Mentions:
61 Fields:
Translation:
AnimalsCells
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DNA microarray analysis reveals a role for lysophosphatidic acid in the regulation of anti-inflammatory genes in MC3T3-E1 cells. Bone. 2007 Nov; 41(5):833-41.
Waters KM, Tan R, Genetos DC, Verma S, Yellowley CE, Karin NJ. PMID: 17719864.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Oscillating fluid flow activation of gap junction hemichannels induces ATP release from MLO-Y4 osteocytes. J Cell Physiol. 2007 Jul; 212(1):207-14.
Genetos DC, Kephart CJ, Zhang Y, Yellowley CE, Donahue HJ. PMID: 17301958; PMCID: PMC2929812.
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PubMed Mentions:
167 Fields:
Translation:
AnimalsCells
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Hypoxia regulates PGE(2) release and EP1 receptor expression in osteoblastic cells. J Cell Physiol. 2007 Jul; 212(1):182-8.
Lee CM, Genetos DC, You Z, Yellowley CE. PMID: 17370287; PMCID: PMC2929130.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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MAP kinase and calcium signaling mediate fluid flow-induced human mesenchymal stem cell proliferation. Am J Physiol Cell Physiol. 2006 Mar; 290(3):C776-84.
Riddle RC, Taylor AF, Genetos DC, Donahue HJ. PMID: 16267109.
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PubMed Mentions:
65 Fields:
Translation:
HumansCells
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Intercellular communication and mechanotransduction in bone. Current Orthopaedic Practice. 2005 Oct 1; 16(5):311-315.
Genetos GD, Donahue DH. .
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Publisher Site Mentions:
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Fluid shear-induced ATP secretion mediates prostaglandin release in MC3T3-E1 osteoblasts. J Bone Miner Res. 2005 Jan; 20(1):41-9.
Genetos DC, Geist DJ, Liu D, Donahue HJ, Duncan RL. PMID: 15619668; PMCID: PMC2929123.
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PubMed Mentions:
104 Fields:
Translation:
AnimalsCells
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Annexin V disruption impairs mechanically induced calcium signaling in osteoblastic cells. Bone. 2004 Sep; 35(3):656-63.
Haut Donahue TL, Genetos DC, Jacobs CR, Donahue HJ, Yellowley CE. PMID: 15336601.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Fluid shear-induced NFkappaB translocation in osteoblasts is mediated by intracellular calcium release. Bone. 2003 Sep; 33(3):399-410.
Chen NX, Geist DJ, Genetos DC, Pavalko FM, Duncan RL. PMID: 13678782.
View in:
PubMed Mentions:
28 Fields:
Translation:
AnimalsCells