Melanie Gareau

Title(s)Associate Professor, School of Veterinary Medicine
SchoolSchool of Veterinary Medicine
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    McMaster University, Hamilton, ON, CanadaPhD10/2006Gastrointestinal Physiology
    Hospital for Sick Children, Toronto, ON, CanadaPost-doc10/2011Microbiology

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    Probiotics and the microbiota-gut-brain axis
    NIH R01AT009365Dec 1, 2016 - Nov 30, 2021
    Role: Principal Investigator
    Early microbial colonization and development of the microbiota-gut-brain axis
    NIH R21MH108154Aug 15, 2015 - May 31, 2018
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Milk and Lacticaseibacillus casei BL23 effects on intestinal responses in a murine model of colitis. Am J Physiol Gastrointest Liver Physiol. 2024 Apr 09. Bui G, Torres-Fuentes C, Pusceddu MM, Gareau MG, Marco ML. PMID: 38591132.
      View in: PubMed   Mentions:
    2. PrestoCell: A persistence-based clustering approach for rapid and robust segmentation of cellular morphology in three-dimensional data. PLoS One. 2024; 19(2):e0299006. Wu Y, Brust-Mascher I, Gareau MG, De Loera JA, Reardon C. PMID: 38422108; PMCID: PMC10903871.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    3. In response to the letter by BOSTANCIKLIOGLU. Brain Behav Immun. 2022 03; 101:59. Gareau MG. PMID: 34968717.
      View in: PubMed   Mentions:    Fields:    
    4. Region-Specific Cell Membrane N-Glycome of Functional Mouse Brain Areas Revealed by nanoLC-MS Analysis. Mol Cell Proteomics. 2021; 20:100130. Barboza M, Solakyildirim K, Knotts TA, Luke J, Gareau MG, Raybould HE, Lebrilla CB. PMID: 34358619; PMCID: PMC8426282.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    5. Skin-brain axis signaling mediates behavioral changes after skin wounding. Brain Behav Immun Health. 2021 Aug; 15:100279. Fregoso DR, Hadian Y, Gallegos AC, Degovics D, Maaga J, Keogh CE, Kletenik I, Gareau MG, Isseroff RR. PMID: 34589779; PMCID: PMC8474598.
      View in: PubMed   Mentions: 4  
    6. Shaping the future of physiology. J Physiol. 2020 07; 598(13):2511-2512. Ferdek P, Gareau MG, Gonzalez J, Wilson C. PMID: 32608047; PMCID: PMC7584148.
      View in: PubMed   Mentions:    Fields:    
    7. Enteropathogenic Escherichia coli Infection Inhibits Intestinal Ascorbic Acid Uptake via Dysregulation of Its Transporter Expression. Dig Dis Sci. 2021 07; 66(7):2250-2260. Heskett CW, Teafatiller T, Hennessey C, Gareau MG, Marchant JS, Said HM, Subramanian VS. PMID: 32556816; PMCID: PMC7744340.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    8. Sensory Nociceptive Neurons Contribute to Host Protection During Enteric Infection With Citrobacter rodentium. J Infect Dis. 2020 06 11; 221(12):1978-1988. Ramirez VT, Sladek J, Godinez DR, Rude KM, Chicco P, Murray K, Brust-Mascher I, Gareau MG, Reardon C. PMID: 31960920; PMCID: PMC7289549.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    9. Microbiome-skin-brain axis: A novel paradigm for cutaneous wounds. Wound Repair Regen. 2020 05; 28(3):282-292. Hadian Y, Fregoso D, Nguyen C, Bagood MD, Dahle SE, Gareau MG, Isseroff RR. PMID: 32034844.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    10. The role of the gut microbiome in mediating neurotoxic outcomes to PCB exposure. Neurotoxicology. 2019 12; 75:30-40. Rude KM, Keogh CE, Gareau MG. PMID: 31454514; PMCID: PMC6842122.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    11. Sexually Dimorphic Influence of Neonatal Antibiotics on Bone. J Orthop Res. 2019 10; 37(10):2122-2129. Pusceddu MM, Stokes PJ, Wong A, Gareau MG, Genetos DC. PMID: 31228216; PMCID: PMC6886746.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    12. Developmental exposure to polychlorinated biphenyls (PCBs) in the maternal diet causes host-microbe defects in weanling offspring mice. Environ Pollut. 2019 Oct; 253:708-721. Rude KM, Pusceddu MM, Keogh CE, Sladek JA, Rabasa G, Miller EN, Sethi S, Keil KP, Pessah IN, Lein PJ, Gareau MG. PMID: 31336350; PMCID: PMC6719698.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    13. Topical Fluoxetine as a Novel Therapeutic That Improves Wound Healing in Diabetic Mice. Diabetes. 2019 07; 68(7):1499-1507. Nguyen CM, Tartar DM, Bagood MD, So M, Nguyen AV, Gallegos A, Fregoso D, Serrano J, Nguyen D, Degovics D, Adams A, Harouni B, Fuentes JJ, Gareau MG, Crawford RW, Soulika AM, Isseroff RR. PMID: 31048368; PMCID: PMC6609984.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    14. T-cell derived acetylcholine aids host defenses during enteric bacterial infection with Citrobacter rodentium. PLoS Pathog. 2019 04; 15(4):e1007719. Ramirez VT, Godinez DR, Brust-Mascher I, Nonnecke EB, Castillo PA, Gardner MB, Tu D, Sladek JA, Miller EN, Lebrilla CB, Bevins CL, Gareau MG, Reardon C. PMID: 30973939; PMCID: PMC6478367.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    15. Visceral pain: gut microbiota, a new hope? J Biomed Sci. 2018 Oct 11; 25(1):73. Pusceddu MM, Gareau MG. PMID: 30309367; PMCID: PMC6182804.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    16. Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera. PLoS Pathog. 2018 06; 14(6):e1007133. Alisson-Silva F, Liu JZ, Diaz SL, Deng L, Gareau MG, Marchelletta R, Chen X, Nizet V, Varki N, Barrett KE, Varki A. PMID: 29912959; PMCID: PMC6023241.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    17. Targeting the Microbiota, from Irritable Bowel Syndrome to Mood Disorders: Focus on Probiotics and Prebiotics. Curr Pathobiol Rep. 2018 Mar; 6(1):1-13. Pusceddu MM, Murray K, Gareau MG. PMID: 29785336; PMCID: PMC5958897.
      View in: PubMed   Mentions: 11  
    18. Intestinal Lactobacillus in health and disease, a driver or just along for the ride? Curr Opin Biotechnol. 2018 02; 49:140-147. Heeney DD, Gareau MG, Marco ML. PMID: 28866243; PMCID: PMC5808898.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansAnimalsCells
    19. Neuroanatomy of the spleen: Mapping the relationship between sympathetic neurons and lymphocytes. PLoS One. 2017; 12(7):e0182416. Murray K, Godinez DR, Brust-Mascher I, Miller EN, Gareau MG, Reardon C. PMID: 28753658; PMCID: PMC5533443.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    20. Cognitive Function and the Microbiome. Int Rev Neurobiol. 2016; 131:227-246. Gareau MG. PMID: 27793221.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    21. Modulation of the microbiota-gut-brain axis by probiotics in a murine model of inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol. 2016 06 01; 310(11):G989-98. Emge JR, Huynh K, Miller EN, Kaur M, Reardon C, Barrett KE, Gareau MG. PMID: 27056723.
      View in: PubMed   Mentions: 57     Fields:    Translation:Animals
    22. High fat diet causes depletion of intestinal eosinophils associated with intestinal permeability. PLoS One. 2015; 10(4):e0122195. Johnson AM, Costanzo A, Gareau MG, Armando AM, Quehenberger O, Jameson JM, Olefsky JM. PMID: 25837594; PMCID: PMC4383570.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    23. Salmonella-induced Diarrhea Occurs in the Absence of IL-8 Receptor (CXCR2)-Dependent Neutrophilic Inflammation. J Infect Dis. 2015 Jul 01; 212(1):128-36. Marchelletta RR, Gareau MG, Okamoto S, Guiney DG, Barrett KE, Fierer J. PMID: 25538271; PMCID: PMC4542593.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    24. TRPM8 on mucosal sensory nerves regulates colitogenic responses by innate immune cells via CGRP. Mucosal Immunol. 2015 May; 8(3):491-504. de Jong PR, Takahashi N, Peiris M, Bertin S, Lee J, Gareau MG, Paniagua A, Harris AR, Herdman DS, Corr M, Blackshaw LA, Raz E. PMID: 25269705; PMCID: PMC4382463.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    25. Probiotics normalize the gut-brain-microbiota axis in immunodeficient mice. Am J Physiol Gastrointest Liver Physiol. 2014 Oct 15; 307(8):G793-802. Smith CJ, Emge JR, Berzins K, Lung L, Khamishon R, Shah P, Rodrigues DM, Sousa AJ, Reardon C, Sherman PM, Barrett KE, Gareau MG. PMID: 25190473; PMCID: PMC4200314.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    26. Microbiota-gut-brain axis and cognitive function. Adv Exp Med Biol. 2014; 817:357-71. Gareau MG. PMID: 24997042.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimals
    27. Fluid and electrolyte secretion in the inflamed gut: novel targets for treatment of inflammation-induced diarrhea. Curr Opin Pharmacol. 2013 Dec; 13(6):895-9. Gareau MG, Barrett KE. PMID: 24054811.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    28. Altered expression and localization of ion transporters contribute to diarrhea in mice with Salmonella-induced enteritis. Gastroenterology. 2013 Dec; 145(6):1358-1368.e1-4. Marchelletta RR, Gareau MG, McCole DF, Okamoto S, Roel E, Klinkenberg R, Guiney DG, Fierer J, Barrett KE. PMID: 24001788; PMCID: PMC3899031.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    29. Rac2-deficiency leads to exacerbated and protracted colitis in response to Citrobacter rodentium infection. PLoS One. 2013; 8(4):e61629. Fattouh R, Guo CH, Lam GY, Gareau MG, Ngan BY, Glogauer M, Muise AM, Brumell JH. PMID: 23613889; PMCID: PMC3628927.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    30. TLR3, TRIF, and caspase 8 determine double-stranded RNA-induced epithelial cell death and survival in vivo. J Immunol. 2013 Jan 01; 190(1):418-27. McAllister CS, Lakhdari O, Pineton de Chambrun G, Gareau MG, Broquet A, Lee GH, Shenouda S, Eckmann L, Kagnoff MF. PMID: 23209324; PMCID: PMC3551582.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    31. Matrix metalloproteinase 9 contributes to gut microbe homeostasis in a model of infectious colitis. BMC Microbiol. 2012 Jun 13; 12:105. Rodrigues DM, Sousa AJ, Hawley SP, Vong L, Gareau MG, Kumar SA, Johnson-Henry KC, Sherman PM. PMID: 22694805; PMCID: PMC3676156.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    32. Probiotics are effective for the prevention and treatment of Citrobacter rodentium-induced colitis in mice. J Infect Dis. 2012 Jul 01; 206(1):99-109. Rodrigues DM, Sousa AJ, Johnson-Henry KC, Sherman PM, Gareau MG. PMID: 22430833.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    33. Diet and nerves: the impact of maternal feeding on newborn intestinal permeability. J Physiol. 2011 Sep 01; 589(17):4091. Gareau MG. PMID: 21885444; PMCID: PMC3180567.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. Thymic stromal lymphopoetin-induced expression of the endogenous inhibitory enzyme SLPI mediates recovery from colonic inflammation. Immunity. 2011 Aug 26; 35(2):223-35. Reardon C, Lechmann M, Brüstle A, Gareau MG, Shuman N, Philpott D, Ziegler SF, Mak TW. PMID: 21820333; PMCID: PMC3169330.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    35. Enterohaemorrhagic, but not enteropathogenic, Escherichia coli infection of epithelial cells disrupts signalling responses to tumour necrosis factor-alpha. Microbiology (Reading). 2011 Oct; 157(Pt 10):2963-2973. Gareau MG, Ho NK, Brenner D, Sousa AJ, LeBourhis L, Mak TW, Girardin SE, Philpott DJ, Sherman PM. PMID: 21798984.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    36. Bacterial infection causes stress-induced memory dysfunction in mice. Gut. 2011 Mar; 60(3):307-17. Gareau MG, Wine E, Rodrigues DM, Cho JH, Whary MT, Philpott DJ, Macqueen G, Sherman PM. PMID: 20966022.
      View in: PubMed   Mentions: 341     Fields:    Translation:AnimalsCells
    37. Probiotics and the gut microbiota in intestinal health and disease. Nat Rev Gastroenterol Hepatol. 2010 Sep; 7(9):503-14. Gareau MG, Sherman PM, Walker WA. PMID: 20664519; PMCID: PMC4748966.
      View in: PubMed   Mentions: 318     Fields:    Translation:Humans
    38. Lactobacillus rhamnosus GG attenuates interferon-{gamma} and tumour necrosis factor-alpha-induced barrier dysfunction and pro-inflammatory signalling. Microbiology (Reading). 2010 Nov; 156(Pt 11):3288-3297. Donato KA, Gareau MG, Wang YJJ, Sherman PM. PMID: 20656777.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    39. Osteopontin mediates Citrobacter rodentium-induced colonic epithelial cell hyperplasia and attaching-effacing lesions. Am J Pathol. 2010 Sep; 177(3):1320-32. Wine E, Shen-Tu G, Gareau MG, Goldberg HA, Licht C, Ngan BY, Sorensen ES, Greenaway J, Sodek J, Zohar R, Sherman PM. PMID: 20651246; PMCID: PMC2928965.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    40. Probiotics prevent death caused by Citrobacter rodentium infection in neonatal mice. J Infect Dis. 2010 Jan 01; 201(1):81-91. Gareau MG, Wine E, Reardon C, Sherman PM. PMID: 19961304.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    41. Prokineticin-1 evokes secretory and contractile activity in rat small intestine. Neurogastroenterol Motil. 2010 May; 22(5):e152-61. Wade PR, Palmer JM, Mabus J, Saunders PR, Prouty S, Chevalier K, Gareau MG, McKenney S, Hornby PJ. PMID: 19930539.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    42. Strain-specific probiotic (Lactobacillus helveticus) inhibition of Campylobacter jejuni invasion of human intestinal epithelial cells. FEMS Microbiol Lett. 2009 Nov; 300(1):146-52. Wine E, Gareau MG, Johnson-Henry K, Sherman PM. PMID: 19765084.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    43. Early Life Stress Induces Both Acute and Chronic Colonic Barrier Dysfunction. NeoReviews. 2009 Apr 1; 10(4):e191-e197. Gareau GM, Wine WE, Sherman SP. .
      View in: Publisher Site   Mentions:
    44. Chronic peripheral administration of corticotropin-releasing factor causes colonic barrier dysfunction similar to psychological stress. Am J Physiol Gastrointest Liver Physiol. 2008 Sep; 295(3):G452-9. Teitelbaum AA, Gareau MG, Jury J, Yang PC, Perdue MH. PMID: 18635602.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    45. Pathophysiological mechanisms of stress-induced intestinal damage. Curr Mol Med. 2008 Jun; 8(4):274-81. Gareau MG, Silva MA, Perdue MH. PMID: 18537635.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimals
    46. Neonatal maternal separation of rat pups results in abnormal cholinergic regulation of epithelial permeability. Am J Physiol Gastrointest Liver Physiol. 2007 Jul; 293(1):G198-203. Gareau MG, Jury J, Perdue MH. PMID: 17510196.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    47. Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation. Gut. 2007 Nov; 56(11):1522-8. Gareau MG, Jury J, MacQueen G, Sherman PM, Perdue MH. PMID: 17339238; PMCID: PMC2095679.
      View in: PubMed   Mentions: 166     Fields:    Translation:AnimalsCells
    48. Neonatal maternal separation causes colonic dysfunction in rat pups including impaired host resistance. Pediatr Res. 2006 Jan; 59(1):83-8. Gareau MG, Jury J, Yang PC, MacQueen G, Perdue MH. PMID: 16326990.
      View in: PubMed   Mentions: 56     Fields:    Translation:Animals
    49. Neonatal maternal separation predisposes adult rats to colonic barrier dysfunction in response to mild stress. Am J Physiol Gastrointest Liver Physiol. 2002 Dec; 283(6):G1257-63. Söderholm JD, Yates DA, Gareau MG, Yang PC, MacQueen G, Perdue MH. PMID: 12388189.
      View in: PubMed   Mentions: 80     Fields:    Translation:Animals