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Charles L. Bevins

TitlePROF-HCOMP
InstitutionUniversity of California Davis
DepartmentMED:MEDICAL MICROBIOLOGY & IMM
AddressMail: 3146 Tupper Hall
CA 95616
Phone530-754-6889
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    Collapse Research 
    Collapse Research Activities and Funding
    Paneth Cell Secreted Effectors in Mucosal Innate Immunity
    NIH/NIAID U01AI125956Jun 15, 2016 - May 31, 2021
    Role: Principal Investigator
    2015 Antimicrobial Peptides Gordon Research Conference &Gordon Research Seminar
    NIH/NIAID R13AI117912Apr 15, 2015 - Aug 31, 2015
    Role: Principal Investigator
    New Mouse Models of Paneth Cell Defensin Function
    NIH/NIAID R21AI099519Feb 7, 2012 - Jan 31, 2015
    Role: Principal Investigator
    Defensin gene copy number and mucosal innate immunity
    NIH/NIAID RC1AI086597Jun 14, 2010 - May 31, 2012
    Role: Principal Investigator
    Host Interactions of Salmonella typhimurium
    NIH/NIAID R01AI076246Mar 1, 2009 - Feb 28, 2014
    Role: Co-Principal Investigator
    In vivo Models of Defensin Activity
    NIH/NIAID R01AI050843Feb 1, 2002 - Jan 31, 2008
    Role: Principal Investigator
    2001 Antimicrobial Peptides Gordon Conference
    NIH/NIAID R13AI050109Mar 15, 2001 - Feb 28, 2002
    Role: Principal Investigator
    Novel Defensins in Human Epithelial Tissues
    NIH/NIAID R01AI032738Jul 1, 1993 - Jan 31, 2020
    Role: Principal Investigator
    Novel Defensins in Human Epithelial Tissues
    NIH/NIAID R37AI032738Jul 1, 1993 - Jan 31, 2020
    Role: Principal Investigator
    TAP--A NOVEL ANTIMICROBIAL PEPTIDE FROM THE TRACHEA
    NIH/NIAID R21AI032234Feb 1, 1992 - Sep 29, 1998
    Role: Principal Investigator
    TAP--A NOVEL ANTIMICROBIAL PEPTIDE FROM THE TRACHEA
    NIH/NIAID R01AI032234Feb 1, 1992 - Jan 31, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bevins C, Bäumler AJ. What's one phosphate between friends (and foe)? Cell Host Microbe. 2015 Jan 14; 17(1):1-3. PMID: 25590752.
      View in: PubMed
    2. Underwood MA, Arriola J, Gerber CW, Kaveti A, Kalanetra KM, Kananurak A, Bevins C, Mills DA, Dvorak B. Bifidobacterium longum subsp. infantis in experimental necrotizing enterocolitis: alterations in inflammation, innate immune response, and the microbiota. Pediatr Res. 2014 Oct; 76(4):326-33. PMID: 25000347; PMCID: PMC4167942.
    3. Bevins C. Innate immune functions of a-defensins in the small intestine. Dig Dis. 2013; 31(3-4):299-304. PMID: 24246978.
      View in: PubMed
    4. Dallas DC, Guerrero A, Khaldi N, Castillo PA, Martin WF, Smilowitz JT, Bevins C, Barile D, German JB, Lebrilla CB. Extensive in vivo human milk peptidomics reveals specific proteolysis yielding protective antimicrobial peptides. J Proteome Res. 2013 May 03; 12(5):2295-304. PMID: 23586814; PMCID: PMC3662810.
    5. Rivera-Chávez F, Winter SE, Lopez CA, Xavier MN, Winter MG, Nuccio SP, Russell JM, Laughlin RC, Lawhon SD, Sterzenbach T, Bevins C, Tsolis RM, Harshey R, Adams LG, Bäumler AJ. Salmonella uses energy taxis to benefit from intestinal inflammation. PLoS Pathog. 2013; 9(4):e1003267. PMID: 23637594; PMCID: PMC3630101.
    6. Clevers HC, Bevins C. Paneth cells: maestros of the small intestinal crypts. Annu Rev Physiol. 2013; 75:289-311. PMID: 23398152.
      View in: PubMed
    7. Schunter M, Chu H, Hayes TL, McConnell D, Crawford SS, Luciw PA, Bengmark S, Asmuth DM, Brown J, Bevins C, Shacklett BL, Critchfield JW. Randomized pilot trial of a synbiotic dietary supplement in chronic HIV-1 infection. BMC Complement Altern Med. 2012 Jun 29; 12:84. PMID: 22747752; PMCID: PMC3414771.
    8. Chu H, Pazgier M, Jung G, Nuccio SP, Castillo PA, de Jong MF, Winter MG, Winter SE, Wehkamp J, Shen B, Salzman NH, Underwood MA, Tsolis RM, Young GM, Lu W, Lehrer RI, Bäumler AJ, Bevins C. Human a-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets. Science. 2012 Jul 27; 337(6093):477-81. PMID: 22722251; PMCID: PMC4332406.
    9. Tollner TL, Bevins C, Cherr GN. Multifunctional glycoprotein DEFB126--a curious story of defensin-clad spermatozoa. Nat Rev Urol. 2012 Jun 19; 9(7):365-75. PMID: 22710670.
      View in: PubMed
    10. Gardner MB, Baumgarth N, Fell A, McSorley SJ, Solnick JV, Bevins C. Meeting report: a symposium on the evolution of common molecular pathways underlying innate immunity. Microbes Infect. 2012 Aug; 14(9):667-71. PMID: 22580093.
      View in: PubMed
    11. Leonard BC, Affolter VK, Bevins C. Antimicrobial peptides: agents of border protection for companion animals. Vet Dermatol. 2012 Jun; 23(3):177-e36. PMID: 22409270; PMCID: PMC3467306.
    12. Leonard BC, Marks SL, Outerbridge CA, Affolter VK, Kananurak A, Young A, Moore PF, Bannasch DL, Bevins C. Activity, expression and genetic variation of canine ß-defensin 103: a multifunctional antimicrobial peptide in the skin of domestic dogs. J Innate Immun. 2012; 4(3):248-59. PMID: 22261569; PMCID: PMC3357142.
    13. Bevins C, Salzman NH. The potter's wheel: the host's role in sculpting its microbiota. Cell Mol Life Sci. 2011 Nov; 68(22):3675-85. PMID: 21968920; PMCID: PMC3222938.
    14. Tollner TL, Venners SA, Hollox EJ, Yudin AI, Liu X, Tang G, Xing H, Kays RJ, Lau T, Overstreet JW, Xu X, Bevins C, Cherr GN. A common mutation in the defensin DEFB126 causes impaired sperm function and subfertility. Sci Transl Med. 2011 Jul 20; 3(92):92ra65. PMID: 21775668; PMCID: PMC3736313.
    15. Leonard BC, Chu H, Johns JL, Gallo RL, Moore PF, Marks SL, Bevins C. Expression and activity of a novel cathelicidin from domestic cats. PLoS One. 2011 Apr 12; 6(4):e18756. PMID: 21533281; PMCID: PMC3075274.
    16. Bevins C, Salzman NH. Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Nat Rev Microbiol. 2011 May; 9(5):356-68. PMID: 21423246.
      View in: PubMed
    17. Winter SE, Thiennimitr P, Winter MG, Butler BP, Huseby DL, Crawford RW, Russell JM, Bevins C, Adams LG, Tsolis RM, Roth JR, Bäumler AJ. Gut inflammation provides a respiratory electron acceptor for Salmonella. Nature. 2010 Sep 23; 467(7314):426-9. PMID: 20864996; PMCID: PMC2946174.
    18. Underwood MA, Bevins C. Defensin-barbed innate immunity: clinical associations in the pediatric population. Pediatrics. 2010 Jun; 125(6):1237-47. PMID: 20478936.
      View in: PubMed
    19. Liu FT, Bevins C. A sweet target for innate immunity. Nat Med. 2010 Mar; 16(3):263-4. PMID: 20208507.
      View in: PubMed
    20. Santos RL, Raffatellu M, Bevins C, Adams LG, Tükel C, Tsolis RM, Bäumler AJ. Life in the inflamed intestine, Salmonella style. Trends Microbiol. 2009 Nov; 17(11):498-506. PMID: 19819699; PMCID: PMC3235402.
    21. Raffatellu M, George MD, Akiyama Y, Hornsby MJ, Nuccio SP, Paixao TA, Butler BP, Chu H, Santos RL, Berger T, Mak TW, Tsolis RM, Bevins C, Solnick JV, Dandekar S, Bäumler AJ. Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine. Cell Host Microbe. 2009 May 08; 5(5):476-86. PMID: 19454351; PMCID: PMC2768556.
    22. Winter SE, Thiennimitr P, Nuccio SP, Haneda T, Winter MG, Wilson RP, Russell JM, Henry T, Tran QT, Lawhon SD, Gomez G, Bevins C, Rüssmann H, Monack DM, Adams LG, Bäumler AJ. Contribution of flagellin pattern recognition to intestinal inflammation during Salmonella enterica serotype typhimurium infection. Infect Immun. 2009 May; 77(5):1904-16. PMID: 19237529; PMCID: PMC2681779.
    23. Koslowski MJ, Kübler I, Chamaillard M, Schaeffeler E, Reinisch W, Wang G, Beisner J, Teml A, Peyrin-Biroulet L, Winter S, Herrlinger KR, Rutgeerts P, Vermeire S, Cooney R, Fellermann K, Jewell D, Bevins C, Schwab M, Stange EF, Wehkamp J. Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease. PLoS One. 2009; 4(2):e4496. PMID: 19221600; PMCID: PMC2637978.
    24. Underwood MA, Salzman NH, Bennett SH, Barman M, Mills DA, Marcobal A, Tancredi DJ, Bevins C, Sherman MP. A randomized placebo-controlled comparison of 2 prebiotic/probiotic combinations in preterm infants: impact on weight gain, intestinal microbiota, and fecal short-chain fatty acids. J Pediatr Gastroenterol Nutr. 2009 Feb; 48(2):216-25. PMID: 19179885; PMCID: PMC2743418.
    25. Godinez I, Raffatellu M, Chu H, Paixão TA, Haneda T, Santos RL, Bevins C, Tsolis RM, Bäumler AJ. Interleukin-23 orchestrates mucosal responses to Salmonella enterica serotype Typhimurium in the intestine. Infect Immun. 2009 Jan; 77(1):387-98. PMID: 18955477; PMCID: PMC2612270.
    26. Yudin AI, Tollner TL, Treece CA, Kays R, Cherr GN, Overstreet JW, Bevins C. Beta-defensin 22 is a major component of the mouse sperm glycocalyx. Reproduction. 2008 Dec; 136(6):753-65. PMID: 18787081; PMCID: PMC3467304.
    27. Karlsson J, Pütsep K, Chu H, Kays RJ, Bevins C, Andersson M. Regional variations in Paneth cell antimicrobial peptide expression along the mouse intestinal tract. BMC Immunol. 2008 Jul 17; 9:37. PMID: 18637162; PMCID: PMC2488317.
    28. George MD, Wehkamp J, Kays RJ, Leutenegger CM, Sabir S, Grishina I, Dandekar S, Bevins C. In vivo gene expression profiling of human intestinal epithelial cells: analysis by laser microdissection of formalin fixed tissues. BMC Genomics. 2008 May 05; 9:209. PMID: 18457593; PMCID: PMC2394537.
    29. Bevins C. Paneth cells, defensins, and IBD. J Pediatr Gastroenterol Nutr. 2008 Apr; 46 Suppl 1:E14-5. PMID: 18354317.
      View in: PubMed
    30. Hornsby MJ, Huff JL, Kays RJ, Canfield DR, Bevins C, Solnick JV. Helicobacter pylori induces an antimicrobial response in rhesus macaques in a cag pathogenicity island-dependent manner. Gastroenterology. 2008 Apr; 134(4):1049-57. PMID: 18395086; PMCID: PMC2386437.
    31. Wehkamp J, Wang G, Kübler I, Nuding S, Gregorieff A, Schnabel A, Kays RJ, Fellermann K, Burk O, Schwab M, Clevers H, Bevins C, Stange EF. The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4. J Immunol. 2007 Sep 01; 179(5):3109-18. PMID: 17709525.
      View in: PubMed
    32. Raffatellu M, Santos RL, Chessa D, Wilson RP, Winter SE, Rossetti CA, Lawhon SD, Chu H, Lau T, Bevins C, Adams LG, Bäumler AJ. The capsule encoding the viaB locus reduces interleukin-17 expression and mucosal innate responses in the bovine intestinal mucosa during infection with Salmonella enterica serotype Typhi. Infect Immun. 2007 Sep; 75(9):4342-50. PMID: 17591794; PMCID: PMC1951168.
    33. Salzman NH, Underwood MA, Bevins C. Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa. Semin Immunol. 2007 Apr; 19(2):70-83. PMID: 17485224.
      View in: PubMed
    34. Wehkamp J, Chu H, Shen B, Feathers RW, Kays RJ, Lee SK, Bevins C. Paneth cell antimicrobial peptides: topographical distribution and quantification in human gastrointestinal tissues. FEBS Lett. 2006 Oct 02; 580(22):5344-50. PMID: 16989824.
      View in: PubMed
    35. Bevins C. Paneth cell defensins: key effector molecules of innate immunity. Biochem Soc Trans. 2006 Apr; 34(Pt 2):263-6. PMID: 16545089.
      View in: PubMed
    36. Wehkamp J, Salzman NH, Porter E, Nuding S, Weichenthal M, Petras RE, Shen B, Schaeffeler E, Schwab M, Linzmeier R, Feathers RW, Chu H, Lima H, Fellermann K, Ganz T, Stange EF, Bevins C. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):18129-34. PMID: 16330776; PMCID: PMC1306791.
    37. Wehkamp J, Fellermann K, Herrlinger KR, Bevins C, Stange EF. Mechanisms of disease: defensins in gastrointestinal diseases. Nat Clin Pract Gastroenterol Hepatol. 2005 Sep; 2(9):406-15. PMID: 16265431.
      View in: PubMed
    38. Sherman MP, Bennett SH, Hwang FF, Sherman J, Bevins C. Paneth cells and antibacterial host defense in neonatal small intestine. Infect Immun. 2005 Sep; 73(9):6143-6. PMID: 16113336; PMCID: PMC1231051.
    39. Bevins C. Events at the host-microbial interface of the gastrointestinal tract. V. Paneth cell alpha-defensins in intestinal host defense. Am J Physiol Gastrointest Liver Physiol. 2005 Aug; 289(2):G173-6. PMID: 16014978.
      View in: PubMed
    40. Bevins C. The Paneth cell and the innate immune response. Curr Opin Gastroenterol. 2004 Nov; 20(6):572-80. PMID: 15703685.
      View in: PubMed
    41. Salzman NH, Ghosh D, Huttner KM, Paterson Y, Bevins C. Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature. 2003 Apr 03; 422(6931):522-6. PMID: 12660734.
      View in: PubMed