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Charles L Bevins

Title(s)Professor, Medical Microbiology and Immunology
SchoolUniversity of California, Davis
Phone530-754-6889
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    Collapse Research 
    Collapse Research Activities and Funding
    2019 Antimicrobial Peptides GRC/GRS
    NIH/NIAID R13AI142722Dec 10, 2018 - Mar 31, 2019
    Role: Principal Investigator
    Paneth Cell Secreted Effectors in Mucosal Innate Immunity
    NIH/NIAID U01AI125956Jun 15, 2016 - May 31, 2021
    Role: Principal Investigator
    2015 Antimicrobial Peptides Gordon Research Conference &Gordon Research Seminar
    NIH/NIAID R13AI117912Apr 15, 2015 - Aug 31, 2015
    Role: Principal Investigator
    New Mouse Models of Paneth Cell Defensin Function
    NIH/NIAID R21AI099519Feb 7, 2012 - Jan 31, 2015
    Role: Principal Investigator
    Defensin gene copy number and mucosal innate immunity
    NIH/NIAID RC1AI086597Jun 14, 2010 - May 31, 2012
    Role: Principal Investigator
    Host Interactions of Salmonella typhimurium
    NIH/NIAID R01AI076246Mar 1, 2009 - Feb 28, 2014
    Role: Co-Principal Investigator
    In vivo Models of Defensin Activity
    NIH/NIAID R01AI050843Feb 1, 2002 - Jan 31, 2008
    Role: Principal Investigator
    2001 Antimicrobial Peptides Gordon Conference
    NIH/NIAID R13AI050109Mar 15, 2001 - Feb 28, 2002
    Role: Principal Investigator
    Novel Defensins in Human Epithelial Tissues
    NIH/NIAID R01AI032738Jul 1, 1993 - Jan 31, 2020
    Role: Principal Investigator
    Novel Defensins in Human Epithelial Tissues
    NIH/NIAID R37AI032738Jul 1, 1993 - Jan 31, 2020
    Role: Principal Investigator
    TAP--A NOVEL ANTIMICROBIAL PEPTIDE FROM THE TRACHEA
    NIH/NIAID R21AI032234Feb 1, 1992 - Sep 29, 1998
    Role: Principal Investigator
    TAP--A NOVEL ANTIMICROBIAL PEPTIDE FROM THE TRACHEA
    NIH/NIAID R01AI032234Feb 1, 1992 - Jan 31, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Castillo PA, Nonnecke EB, Ossorio DT, Tran MTN, Goley SM, Lönnerdal B, Underwood MA, Bevins CL. An Experimental Approach to Rigorously Assess Paneth Cell a-Defensin (Defa) mRNA Expression in C57BL/6 Mice. Sci Rep. 2019 Sep 11; 9(1):13115. PMID: 31511628.
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    2. Lee DC, Kananurak A, Tran MT, Connolly PA, Polage CR, Iwase T, Bevins CL, Underwood MA. Bacterial Colonization of the Hospitalized Newborn: Competition Between Staphylococcus aureus and Staphylococcus epidermidis. Pediatr Infect Dis J. 2019 Jul; 38(7):682-686. PMID: 30985510.
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    3. Ramirez VT, Godinez DR, Brust-Mascher I, Nonnecke EB, Castillo PA, Gardner MB, Tu D, Sladek JA, Miller EN, Lebrilla CB, Bevins CL, Gareau MG, Reardon C. T-cell derived acetylcholine aids host defenses during enteric bacterial infection with Citrobacter rodentium. PLoS Pathog. 2019 04; 15(4):e1007719. PMID: 30973939.
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    4. Xu D, Liao C, Zhang B, Tolbert WD, He W, Dai Z, Zhang W, Yuan W, Pazgier M, Liu J, Yu J, Sansonetti PJ, Bevins CL, Shao Y, Lu W. Human Enteric a-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion. Immunity. 2018 06 19; 48(6):1233-1244.e6. PMID: 29858013.
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    5. Chang C, Lleo A, Kananurak A, Grizzi F, Tsuneyama K, Invernizzi P, Bevins CL, Bowlus CL. Human ß-Defensin 2 in Primary Sclerosing Cholangitis. Clin Transl Gastroenterol. 2017 Mar 16; 8(3):e80. PMID: 28300822.
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    6. Nguyen TT, Kläsener K, Zürn C, Castillo PA, Brust-Mascher I, Imai DM, Bevins CL, Reardon C, Reth M, Baumgarth N. The IgM receptor FcµR limits tonic BCR signaling by regulating expression of the IgM BCR. Nat Immunol. 2017 03; 18(3):321-333. PMID: 28135254.
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    7. Bergman P, Roan NR, Römling U, Bevins CL, Münch J. Amyloid formation: functional friend or fearful foe? J Intern Med. 2016 Aug; 280(2):139-52. PMID: 27151743.
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    8. Chairatana P, Chu H, Castillo PA, Shen B, Bevins CL, Nolan EM. Proteolysis Triggers Self-Assembly and Unmasks Innate Immune Function of a Human a-Defensin Peptide. Chem Sci. 2016 Mar 01; 7(3):1738-1752. PMID: 27076903.
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    9. Bevins CL, Bäumler AJ. What's one phosphate between friends (and foe)? Cell Host Microbe. 2015 Jan 14; 17(1):1-3. PMID: 25590752.
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    10. Ottolini B, Hornsby MJ, Abujaber R, MacArthur JA, Badge RM, Schwarzacher T, Albertson DG, Bevins CL, Solnick JV, Hollox EJ. Evidence of convergent evolution in humans and macaques supports an adaptive role for copy number variation of the ß-defensin-2 gene. Genome Biol Evol. 2014 Oct 27; 6(11):3025-38. PMID: 25349268.
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    11. Underwood MA, Arriola J, Gerber CW, Kaveti A, Kalanetra KM, Kananurak A, Bevins CL, Mills DA, Dvorak B. Bifidobacterium longum subsp. infantis in experimental necrotizing enterocolitis: alterations in inflammation, innate immune response, and the microbiota. Pediatr Res. 2014 Oct; 76(4):326-33. PMID: 25000347.
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    12. Jones EA, Kananurak A, Bevins CL, Hollox EJ, Bakaletz LO. Copy number variation of the beta defensin gene cluster on chromosome 8p influences the bacterial microbiota within the nasopharynx of otitis-prone children. PLoS One. 2014; 9(5):e98269. PMID: 24867293.
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    13. Salzman NH, Bevins CL. Dysbiosis--a consequence of Paneth cell dysfunction. Semin Immunol. 2013 Nov 30; 25(5):334-41. PMID: 24239045.
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    14. Bevins CL. Innate immune functions of a-defensins in the small intestine. Dig Dis. 2013; 31(3-4):299-304. PMID: 24246978.
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    15. Dallas DC, Guerrero A, Khaldi N, Castillo PA, Martin WF, Smilowitz JT, Bevins CL, Barile D, German JB, Lebrilla CB. Extensive in vivo human milk peptidomics reveals specific proteolysis yielding protective antimicrobial peptides. J Proteome Res. 2013 May 03; 12(5):2295-304. PMID: 23586814.
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    16. Rivera-Chávez F, Winter SE, Lopez CA, Xavier MN, Winter MG, Nuccio SP, Russell JM, Laughlin RC, Lawhon SD, Sterzenbach T, Bevins CL, Tsolis RM, Harshey R, Adams LG, Bäumler AJ. Salmonella uses energy taxis to benefit from intestinal inflammation. PLoS Pathog. 2013; 9(4):e1003267. PMID: 23637594.
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    17. McSorley SJ, Bevins CL. Paneth cells: targets of friendly fire. Nat Immunol. 2013 Feb; 14(2):114-6. PMID: 23334825.
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    18. Clevers HC, Bevins CL. Paneth cells: maestros of the small intestinal crypts. Annu Rev Physiol. 2013; 75:289-311. PMID: 23398152.
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    19. Ma BW, Bokulich NA, Castillo PA, Kananurak A, Underwood MA, Mills DA, Bevins CL. Routine habitat change: a source of unrecognized transient alteration of intestinal microbiota in laboratory mice. PLoS One. 2012; 7(10):e47416. PMID: 23082164.
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    20. Schunter M, Chu H, Hayes TL, McConnell D, Crawford SS, Luciw PA, Bengmark S, Asmuth DM, Brown J, Bevins CL, Shacklett BL, Critchfield JW. Randomized pilot trial of a synbiotic dietary supplement in chronic HIV-1 infection. BMC Complement Altern Med. 2012 Jun 29; 12:84. PMID: 22747752.
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    21. Chu H, Pazgier M, Jung G, Nuccio SP, Castillo PA, de Jong MF, Winter MG, Winter SE, Wehkamp J, Shen B, Salzman NH, Underwood MA, Tsolis RM, Young GM, Lu W, Lehrer RI, Bäumler AJ, Bevins CL. Human a-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets. Science. 2012 Jul 27; 337(6093):477-81. PMID: 22722251.
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    22. Tollner TL, Bevins CL, Cherr GN. Multifunctional glycoprotein DEFB126--a curious story of defensin-clad spermatozoa. Nat Rev Urol. 2012 Jun 19; 9(7):365-75. PMID: 22710670.
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    23. Gardner MB, Baumgarth N, Fell A, McSorley SJ, Solnick JV, Bevins CL. Meeting report: a symposium on the evolution of common molecular pathways underlying innate immunity. Microbes Infect. 2012 Aug; 14(9):667-71. PMID: 22580093.
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    24. Leonard BC, Affolter VK, Bevins CL. Antimicrobial peptides: agents of border protection for companion animals. Vet Dermatol. 2012 Jun; 23(3):177-e36. PMID: 22409270.
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    25. Zhao X, Bu DX, Hayfron K, Pinkerton KE, Bevins CL, Lichtman A, Wiedeman J. A combination of secondhand cigarette smoke and Chlamydia pneumoniae accelerates atherosclerosis. Atherosclerosis. 2012 May; 222(1):59-66. PMID: 22410122.
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    26. Spencer JD, Hains DS, Porter E, Bevins CL, DiRosario J, Becknell B, Wang H, Schwaderer AL. Human alpha defensin 5 expression in the human kidney and urinary tract. PLoS One. 2012; 7(2):e31712. PMID: 22359618.
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    27. Teltschik Z, Wiest R, Beisner J, Nuding S, Hofmann C, Schoelmerich J, Bevins CL, Stange EF, Wehkamp J. Intestinal bacterial translocation in rats with cirrhosis is related to compromised Paneth cell antimicrobial host defense. Hepatology. 2012 Apr; 55(4):1154-63. PMID: 22095436.
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    28. Underwood MA, Kananurak A, Coursodon CF, Adkins-Reick CK, Chu H, Bennett SH, Wehkamp J, Castillo PA, Leonard BC, Tancredi DJ, Sherman MP, Dvorak B, Bevins CL. Bifidobacterium bifidum in a rat model of necrotizing enterocolitis: antimicrobial peptide and protein responses. Pediatr Res. 2012 May; 71(5):546-51. PMID: 22322385.
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    29. Leonard BC, Marks SL, Outerbridge CA, Affolter VK, Kananurak A, Young A, Moore PF, Bannasch DL, Bevins CL. Activity, expression and genetic variation of canine ß-defensin 103: a multifunctional antimicrobial peptide in the skin of domestic dogs. J Innate Immun. 2012; 4(3):248-59. PMID: 22261569.
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    30. Bevins CL, Salzman NH. The potter's wheel: the host's role in sculpting its microbiota. Cell Mol Life Sci. 2011 Nov; 68(22):3675-85. PMID: 21968920.
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    31. Tollner TL, Venners SA, Hollox EJ, Yudin AI, Liu X, Tang G, Xing H, Kays RJ, Lau T, Overstreet JW, Xu X, Bevins CL, Cherr GN. A common mutation in the defensin DEFB126 causes impaired sperm function and subfertility. Sci Transl Med. 2011 Jul 20; 3(92):92ra65. PMID: 21775668.
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    32. Leonard BC, Chu H, Johns JL, Gallo RL, Moore PF, Marks SL, Bevins CL. Expression and activity of a novel cathelicidin from domestic cats. PLoS One. 2011 Apr 12; 6(4):e18756. PMID: 21533281.
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    33. Bevins CL, Salzman NH. Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Nat Rev Microbiol. 2011 May; 9(5):356-68. PMID: 21423246.
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    34. Winter SE, Thiennimitr P, Winter MG, Butler BP, Huseby DL, Crawford RW, Russell JM, Bevins CL, Adams LG, Tsolis RM, Roth JR, Bäumler AJ. Gut inflammation provides a respiratory electron acceptor for Salmonella. Nature. 2010 Sep 23; 467(7314):426-9. PMID: 20864996.
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    35. Dhaliwal W, Shawa T, Khanam M, Jagatiya P, Simuyandi M, Ndulo N, Bevins CL, Sanderson IR, Kelly P. Intestinal antimicrobial gene expression: impact of micronutrients in malnourished adults during a randomized trial. J Infect Dis. 2010 Sep 15; 202(6):971-8. PMID: 20695797.
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    36. Biswas A, Liu YJ, Hao L, Mizoguchi A, Salzman NH, Bevins CL, Kobayashi KS. Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum. Proc Natl Acad Sci U S A. 2010 Aug 17; 107(33):14739-44. PMID: 20679225.
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    37. Underwood MA, Bevins CL. Defensin-barbed innate immunity: clinical associations in the pediatric population. Pediatrics. 2010 Jun; 125(6):1237-47. PMID: 20478936.
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    38. Liu FT, Bevins CL. A sweet target for innate immunity. Nat Med. 2010 Mar; 16(3):263-4. PMID: 20208507.
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    39. Untersmayr E, Bises G, Starkl P, Bevins CL, Scheiner O, Boltz-Nitulescu G, Wrba F, Jensen-Jarolim E. The high affinity IgE receptor Fc epsilonRI is expressed by human intestinal epithelial cells. PLoS One. 2010 Feb 02; 5(2):e9023. PMID: 20126404.
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    40. Wolfs TG, Derikx JP, Hodin CM, Vanderlocht J, Driessen A, de Bruïne AP, Bevins CL, Lasitschka F, Gassler N, van Gemert WG, Buurman WA. Localization of the lipopolysaccharide recognition complex in the human healthy and inflamed premature and adult gut. Inflamm Bowel Dis. 2010 Jan; 16(1):68-75. PMID: 20014022.
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    41. Salzman NH, Hung K, Haribhai D, Chu H, Karlsson-Sjöberg J, Amir E, Teggatz P, Barman M, Hayward M, Eastwood D, Stoel M, Zhou Y, Sodergren E, Weinstock GM, Bevins CL, Williams CB, Bos NA. Enteric defensins are essential regulators of intestinal microbial ecology. Nat Immunol. 2010 Jan; 11(1):76-83. PMID: 19855381.
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    42. Santos RL, Raffatellu M, Bevins CL, Adams LG, Tükel C, Tsolis RM, Bäumler AJ. Life in the inflamed intestine, Salmonella style. Trends Microbiol. 2009 Nov; 17(11):498-506. PMID: 19819699.
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    43. Bevins CL, Stange EF, Wehkamp J. Decreased Paneth cell defensin expression in ileal Crohn's disease is independent of inflammation, but linked to the NOD2 1007fs genotype. Gut. 2009 Jun; 58(6):882-3; discussion 883-4. PMID: 19433600.
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    44. Raffatellu M, George MD, Akiyama Y, Hornsby MJ, Nuccio SP, Paixao TA, Butler BP, Chu H, Santos RL, Berger T, Mak TW, Tsolis RM, Bevins CL, Solnick JV, Dandekar S, Bäumler AJ. Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine. Cell Host Microbe. 2009 May 08; 5(5):476-86. PMID: 19454351.
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    45. Winter SE, Thiennimitr P, Nuccio SP, Haneda T, Winter MG, Wilson RP, Russell JM, Henry T, Tran QT, Lawhon SD, Gomez G, Bevins CL, Rüssmann H, Monack DM, Adams LG, Bäumler AJ. Contribution of flagellin pattern recognition to intestinal inflammation during Salmonella enterica serotype typhimurium infection. Infect Immun. 2009 May; 77(5):1904-16. PMID: 19237529.
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    46. Koslowski MJ, Kübler I, Chamaillard M, Schaeffeler E, Reinisch W, Wang G, Beisner J, Teml A, Peyrin-Biroulet L, Winter S, Herrlinger KR, Rutgeerts P, Vermeire S, Cooney R, Fellermann K, Jewell D, Bevins CL, Schwab M, Stange EF, Wehkamp J. Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease. PLoS One. 2009; 4(2):e4496. PMID: 19221600.
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    47. Underwood MA, Salzman NH, Bennett SH, Barman M, Mills DA, Marcobal A, Tancredi DJ, Bevins CL, Sherman MP. A randomized placebo-controlled comparison of 2 prebiotic/probiotic combinations in preterm infants: impact on weight gain, intestinal microbiota, and fecal short-chain fatty acids. J Pediatr Gastroenterol Nutr. 2009 Feb; 48(2):216-25. PMID: 19179885.
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    48. Shen B, Remzi FH, Hammel JP, Lashner BA, Bevins CL, Lavery IC, Wehkamp J, Fazio VW. Family history of Crohn's disease is associated with an increased risk for Crohn's disease of the pouch. Inflamm Bowel Dis. 2009 Feb; 15(2):163-70. PMID: 18798573.
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    49. Mukherjee S, Partch CL, Lehotzky RE, Whitham CV, Chu H, Bevins CL, Gardner KH, Hooper LV. Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegment. J Biol Chem. 2009 Feb 20; 284(8):4881-8. PMID: 19095652.
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    50. Godinez I, Raffatellu M, Chu H, Paixão TA, Haneda T, Santos RL, Bevins CL, Tsolis RM, Bäumler AJ. Interleukin-23 orchestrates mucosal responses to Salmonella enterica serotype Typhimurium in the intestine. Infect Immun. 2009 Jan; 77(1):387-98. PMID: 18955477.
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    51. Yudin AI, Tollner TL, Treece CA, Kays R, Cherr GN, Overstreet JW, Bevins CL. Beta-defensin 22 is a major component of the mouse sperm glycocalyx. Reproduction. 2008 Dec; 136(6):753-65. PMID: 18787081.
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    52. Karlsson J, Pütsep K, Chu H, Kays RJ, Bevins CL, Andersson M. Regional variations in Paneth cell antimicrobial peptide expression along the mouse intestinal tract. BMC Immunol. 2008 Jul 17; 9:37. PMID: 18637162.
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    53. George MD, Wehkamp J, Kays RJ, Leutenegger CM, Sabir S, Grishina I, Dandekar S, Bevins CL. In vivo gene expression profiling of human intestinal epithelial cells: analysis by laser microdissection of formalin fixed tissues. BMC Genomics. 2008 May 05; 9:209. PMID: 18457593.
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    54. Bevins CL. Paneth cells, defensins, and IBD. J Pediatr Gastroenterol Nutr. 2008 Apr; 46 Suppl 1:E14-5. PMID: 18354317.
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    55. Hornsby MJ, Huff JL, Kays RJ, Canfield DR, Bevins CL, Solnick JV. Helicobacter pylori induces an antimicrobial response in rhesus macaques in a cag pathogenicity island-dependent manner. Gastroenterology. 2008 Apr; 134(4):1049-57. PMID: 18395086.
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    56. Salzman NH, Bevins CL. Negative interactions with the microbiota: IBD. Adv Exp Med Biol. 2008; 635:67-78. PMID: 18841704.
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    57. Baumgarth N, Bevins CL. Autoimmune disease: skin deep but complex. Nature. 2007 Oct 04; 449(7162):551-3. PMID: 17873861.
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    58. Wehkamp J, Wang G, Kübler I, Nuding S, Gregorieff A, Schnabel A, Kays RJ, Fellermann K, Burk O, Schwab M, Clevers H, Bevins CL, Stange EF. The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4. J Immunol. 2007 Sep 01; 179(5):3109-18. PMID: 17709525.
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    59. Bevins CL, Liu FT. Rosacea: skin innate immunity gone awry? Nat Med. 2007 Aug; 13(8):904-6. PMID: 17680001.
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    60. Raffatellu M, Santos RL, Chessa D, Wilson RP, Winter SE, Rossetti CA, Lawhon SD, Chu H, Lau T, Bevins CL, Adams LG, Bäumler AJ. The capsule encoding the viaB locus reduces interleukin-17 expression and mucosal innate responses in the bovine intestinal mucosa during infection with Salmonella enterica serotype Typhi. Infect Immun. 2007 Sep; 75(9):4342-50. PMID: 17591794.
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    61. Salzman NH, Underwood MA, Bevins CL. Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa. Semin Immunol. 2007 Apr; 19(2):70-83. PMID: 17485224.
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    62. McGillivary G, Ray WC, Bevins CL, Munson RS, Bakaletz LO. A member of the cathelicidin family of antimicrobial peptides is produced in the upper airway of the chinchilla and its mRNA expression is altered by common viral and bacterial co-pathogens of otitis media. Mol Immunol. 2007 Mar; 44(9):2446-58. PMID: 17113647.
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    63. Wehkamp J, Chu H, Shen B, Feathers RW, Kays RJ, Lee SK, Bevins CL. Paneth cell antimicrobial peptides: topographical distribution and quantification in human gastrointestinal tissues. FEBS Lett. 2006 Oct 02; 580(22):5344-50. PMID: 16989824.
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    64. Fellermann K, Stange DE, Schaeffeler E, Schmalzl H, Wehkamp J, Bevins CL, Reinisch W, Teml A, Schwab M, Lichter P, Radlwimmer B, Stange EF. A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon. Am J Hum Genet. 2006 Sep; 79(3):439-48. PMID: 16909382.
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    65. Kelly P, Bajaj-Elliott M, Katubulushi M, Zulu I, Poulsom R, Feldman RA, Bevins CL, Dhaliwal W. Reduced gene expression of intestinal alpha-defensins predicts diarrhea in a cohort of African adults. J Infect Dis. 2006 May 15; 193(10):1464-70. PMID: 16619196.
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    66. Bevins CL. Paneth cell defensins: key effector molecules of innate immunity. Biochem Soc Trans. 2006 Apr; 34(Pt 2):263-6. PMID: 16545089.
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    67. Shen B, Fazio VW, Remzi FH, Brzezinski A, Bennett AE, Lopez R, Hammel JP, Achkar JP, Bevins CL, Lavery IC, Strong SA, Delaney CP, Liu W, Bambrick ML, Sherman KK, Lashner BA. Risk factors for diseases of ileal pouch-anal anastomosis after restorative proctocolectomy for ulcerative colitis. Clin Gastroenterol Hepatol. 2006 Jan; 4(1):81-9; quiz 2-3. PMID: 16431309.
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    68. Wehkamp J, Salzman NH, Porter E, Nuding S, Weichenthal M, Petras RE, Shen B, Schaeffeler E, Schwab M, Linzmeier R, Feathers RW, Chu H, Lima H, Fellermann K, Ganz T, Stange EF, Bevins CL. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):18129-34. PMID: 16330776.
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    69. Wehkamp J, Fellermann K, Herrlinger KR, Bevins CL, Stange EF. Mechanisms of disease: defensins in gastrointestinal diseases. Nat Clin Pract Gastroenterol Hepatol. 2005 Sep; 2(9):406-15. PMID: 16265431.
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    70. Sherman MP, Bennett SH, Hwang FF, Sherman J, Bevins CL. Paneth cells and antibacterial host defense in neonatal small intestine. Infect Immun. 2005 Sep; 73(9):6143-6. PMID: 16113336.
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    71. Bevins CL. Events at the host-microbial interface of the gastrointestinal tract. V. Paneth cell alpha-defensins in intestinal host defense. Am J Physiol Gastrointest Liver Physiol. 2005 Aug; 289(2):G173-6. PMID: 16014978.
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    72. Shen B, Porter EM, Reynoso E, Shen C, Ghosh D, Connor JT, Drazba J, Rho HK, Gramlich TL, Li R, Ormsby AH, Sy MS, Ganz T, Bevins CL. Human defensin 5 expression in intestinal metaplasia of the upper gastrointestinal tract. J Clin Pathol. 2005 Jul; 58(7):687-94. PMID: 15976333.
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    73. Bevins CL. An important clue: fingerprints point to psoriasin in defense against E. coli. Nat Immunol. 2005 Jan; 6(1):12-3. PMID: 15611775.
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    74. Shen B, Zuccaro G, Gramlich TL, Gladkova N, Trolli P, Kareta M, Delaney CP, Connor JT, Lashner BA, Bevins CL, Feldchtein F, Remzi FH, Bambrick ML, Fazio VW. In vivo colonoscopic optical coherence tomography for transmural inflammation in inflammatory bowel disease. Clin Gastroenterol Hepatol. 2004 Dec; 2(12):1080-7. PMID: 15625653.
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    75. Bevins CL. The Paneth cell and the innate immune response. Curr Opin Gastroenterol. 2004 Nov; 20(6):572-80. PMID: 15703685.
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    76. Wehkamp J, Harder J, Weichenthal M, Schwab M, Schäffeler E, Schlee M, Herrlinger KR, Stallmach A, Noack F, Fritz P, Schröder JM, Bevins CL, Fellermann K, Stange EF. NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Gut. 2004 Nov; 53(11):1658-64. PMID: 15479689.
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    77. Shen B, Zuccaro G, Gramlich TL, Gladkova N, Lashner BA, Delaney CP, Connor JT, Remzi FH, Kareta M, Bevins CL, Feldchtein F, Strong SA, Bambrick ML, Trolli P, Fazio VW. Ex vivo histology-correlated optical coherence tomography in the detection of transmural inflammation in Crohn's disease. Clin Gastroenterol Hepatol. 2004 Sep; 2(9):754-60. PMID: 15354275.
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    78. Harris RH, Wilk D, Bevins CL, Munson RS, Bakaletz LO. Identification and characterization of a mucosal antimicrobial peptide expressed by the chinchilla (Chinchilla lanigera) airway. J Biol Chem. 2004 May 07; 279(19):20250-6. PMID: 14996845.
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    79. Kelly P, Feakins R, Domizio P, Murphy J, Bevins C, Wilson J, McPhail G, Poulsom R, Dhaliwal W. Paneth cell granule depletion in the human small intestine under infective and nutritional stress. Clin Exp Immunol. 2004 Feb; 135(2):303-9. PMID: 14738460.
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    80. Shen B, Shermock KM, Fazio VW, Achkar JP, Brzezinski A, Bevins CL, Bambrick ML, Remzi FH, Lashner BA. A cost-effectiveness analysis of diagnostic strategies for symptomatic patients with ileal pouch-anal anastomosis. Am J Gastroenterol. 2003 Nov; 98(11):2460-7. PMID: 14638349.
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    81. Howell SJ, Wilk D, Yadav SP, Bevins CL. Antimicrobial polypeptides of the human colonic epithelium. Peptides. 2003 Nov; 24(11):1763-70. PMID: 15019208.
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    82. Shen B, Achkar JP, Connor JT, Ormsby AH, Remzi FH, Bevins CL, Brzezinski A, Bambrick ML, Fazio VW, Lashner BA. Modified pouchitis disease activity index: a simplified approach to the diagnosis of pouchitis. Dis Colon Rectum. 2003 Jun; 46(6):748-53. PMID: 12794576.
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    83. Salzman NH, Ghosh D, Huttner KM, Paterson Y, Bevins CL. Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature. 2003 Apr 03; 422(6931):522-6. PMID: 12660734.
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    84. Bevins CL. Antimicrobial peptides as effector molecules of mammalian host defense. Contrib Microbiol. 2003; 10:106-48. PMID: 12530324.
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    85. Ghosh D, Porter E, Shen B, Lee SK, Wilk D, Drazba J, Yadav SP, Crabb JW, Ganz T, Bevins CL. Paneth cell trypsin is the processing enzyme for human defensin-5. Nat Immunol. 2002 Jun; 3(6):583-90. PMID: 12021776.
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    86. Shen B, Achkar JP, Lashner BA, Ormsby AH, Brzezinski A, Soffer EE, Remzi FH, Bevins CL, Fazio VW. Irritable pouch syndrome: a new category of diagnosis for symptomatic patients with ileal pouch-anal anastomosis. Am J Gastroenterol. 2002 Apr; 97(4):972-7. PMID: 12003434.
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    87. Shen B, Ormsby AH, Shen C, Dumot JA, Shao YW, Bevins CL, Gramlich TL. Cytokeratin expression patterns in noncardia, intestinal metaplasia-associated gastric adenocarcinoma: implication for the evaluation of intestinal metaplasia and tumors at the esophagogastric junction. Cancer. 2002 Feb 01; 94(3):820-31. PMID: 11857318.
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    88. Porter EM, Bevins CL, Ghosh D, Ganz T. The multifaceted Paneth cell. Cell Mol Life Sci. 2002 Jan; 59(1):156-70. PMID: 11846026.
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    89. Shen B, Achkar JP, Lashner BA, Ormsby AH, Remzi FH, Brzezinski A, Bevins CL, Bambrick ML, Seidner DL, Fazio VW. A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis. Inflamm Bowel Dis. 2001 Nov; 7(4):301-5. PMID: 11720319.
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    90. Shen B, Achkar JP, Lashner BA, Ormsby AH, Remzi FH, Bevins CL, Brzezinski A, Petras RE, Fazio VW. Endoscopic and histologic evaluation together with symptom assessment are required to diagnose pouchitis. Gastroenterology. 2001 Aug; 121(2):261-7. PMID: 11487535.
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    91. Robertson DJ, Sandler RS. Measles virus and Crohn's disease: a critical appraisal of the current literature. Inflamm Bowel Dis. 2001 Feb; 7(1):51-7. PMID: 11233661.
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    92. Jia HP, Wowk SA, Schutte BC, Lee SK, Vivado A, Tack BF, Bevins CL, McCray PB. A novel murine beta -defensin expressed in tongue, esophagus, and trachea. J Biol Chem. 2000 Oct 27; 275(43):33314-20. PMID: 10922379.
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    93. Diamond G, Kaiser V, Rhodes J, Russell JP, Bevins CL. Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells. Infect Immun. 2000 Jan; 68(1):113-9. PMID: 10603376.
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    94. Bevins CL, Martin-Porter E, Ganz T. Defensins and innate host defence of the gastrointestinal tract. Gut. 1999 Dec; 45(6):911-5. PMID: 10562592.
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    95. Yount NY, Yuan J, Tarver A, Castro T, Diamond G, Tran PA, Levy JN, McCullough C, Cullor JS, Bevins CL, Selsted ME. Cloning and expression of bovine neutrophil beta-defensins. Biosynthetic profile during neutrophilic maturation and localization of mature peptide to novel cytoplasmic dense granules. J Biol Chem. 1999 Sep 10; 274(37):26249-58. PMID: 10473579.
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    96. Jia HP, Mills JN, Barahmand-Pour F, Nishimura D, Mallampali RK, Wang G, Wiles K, Tack BF, Bevins CL, McCray PB. Molecular cloning and characterization of rat genes encoding homologues of human beta-defensins. Infect Immun. 1999 Sep; 67(9):4827-33. PMID: 10456937.
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    97. Huttner KM, Bevins CL. Antimicrobial peptides as mediators of epithelial host defense. Pediatr Res. 1999 Jun; 45(6):785-94. PMID: 10367766.
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    98. Bevins CL. Scratching the surface: inroads to a better understanding of airway host defense. Am J Respir Cell Mol Biol. 1999 May; 20(5):861-3. PMID: 10226055.
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    99. Porter EM, Poles MA, Lee JS, Naitoh J, Bevins CL, Ganz T. Isolation of human intestinal defensins from ileal neobladder urine. FEBS Lett. 1998 Sep 04; 434(3):272-6. PMID: 9742937.
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    100. Diamond G, Bevins CL. beta-Defensins: endogenous antibiotics of the innate host defense response. Clin Immunol Immunopathol. 1998 Sep; 88(3):221-5. PMID: 9743607.
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    101. Salzman NH, Polin RA, Harris MC, Ruchelli E, Hebra A, Zirin-Butler S, Jawad A, Martin Porter E, Bevins CL. Enteric defensin expression in necrotizing enterocolitis. Pediatr Res. 1998 Jul; 44(1):20-6. PMID: 9667365.
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    102. Tarver AP, Clark DP, Diamond G, Russell JP, Erdjument-Bromage H, Tempst P, Cohen KS, Jones DE, Sweeney RW, Wines M, Hwang S, Bevins CL. Enteric beta-defensin: molecular cloning and characterization of a gene with inducible intestinal epithelial cell expression associated with Cryptosporidium parvum infection. Infect Immun. 1998 Mar; 66(3):1045-56. PMID: 9488394.
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    103. Huttner KM, Kozak CA, Bevins CL. The mouse genome encodes a single homolog of the antimicrobial peptide human beta-defensin 1. FEBS Lett. 1997 Aug 11; 413(1):45-9. PMID: 9287114.
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    104. Bevins CL, Lashner BA. Searching for the ulcerative colitis genes. Am J Gastroenterol. 1997 May; 92(5):733-4. PMID: 9149178.
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    105. Bevins CL, Diamond G. Molecular biological strategies in the analysis of antibiotic peptide gene families. The use oligonucleotides as hybridization probes. Methods Mol Biol. 1997; 78:151-66. PMID: 9276303.
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    106. Wei X, Eisman R, Xu J, Harsch AD, Mulberg AE, Bevins CL, Glick MC, Scanlin TF. Turnover of the cystic fibrosis transmembrane conductance regulator (CFTR): slow degradation of wild-type and delta F508 CFTR in surface membrane preparations of immortalized airway epithelial cells. J Cell Physiol. 1996 Aug; 168(2):373-84. PMID: 8707873.
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    107. Diamond G, Russell JP, Bevins CL. Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):5156-60. PMID: 8643545.
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    108. Russell JP, Diamond G, Tarver AP, Scanlin TF, Bevins CL. Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha. Infect Immun. 1996 May; 64(5):1565-8. PMID: 8613361.
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    109. Mallow EB, Harris A, Salzman N, Russell JP, DeBerardinis RJ, Ruchelli E, Bevins CL. Human enteric defensins. Gene structure and developmental expression. J Biol Chem. 1996 Feb 23; 271(8):4038-45. PMID: 8626737.
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    110. Bevins CL, Jones DE, Dutra A, Schaffzin J, Muenke M. Human enteric defensin genes: chromosomal map position and a model for possible evolutionary relationships. Genomics. 1996 Jan 01; 31(1):95-106. PMID: 8808285.
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    111. Iannuzzi L, Gallagher DS, Di Meo GP, Diamond G, Bevins CL, Womack JE. High-resolution FISH mapping of beta-defensin genes to river buffalo and sheep chromosomes suggests a chromosome discrepancy in ffttle standard karyotypes. Cytogenet Cell Genet. 1996; 75(1):10-3. PMID: 8995479.
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    112. Gallagher DS, Ryan AM, Diamond G, Bevins CL, Womack JE. Somatic cell mapping of beta-defensin genes to cattle syntenic group U25 and fluorescence in situ localization to chromosome 27. Mamm Genome. 1995 Aug; 6(8):554-6. PMID: 8589529.
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    113. Godfrey M, Raghunath M, Cisler J, Bevins CL, DePaepe A, Di Rocco M, Gregoritch J, Imaizumi K, Kaplan P, Kuroki Y. Abnormal morphology of fibrillin microfibrils in fibroblast cultures from patients with neonatal Marfan syndrome. Am J Pathol. 1995 Jun; 146(6):1414-21. PMID: 7778680.
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    114. Reilly DS, Tomassini N, Bevins CL, Zasloff M. A Paneth cell analogue in Xenopus small intestine expresses antimicrobial peptide genes: conservation of an intestinal host-defense system. J Histochem Cytochem. 1994 Jun; 42(6):697-704. PMID: 8189032.
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    115. Diamond G, Bevins CL. Endotoxin upregulates expression of an antimicrobial peptide gene in mammalian airway epithelial cells. Chest. 1994 Mar; 105(3 Suppl):51S-52S. PMID: 8131611.
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    116. Bevins CL. Antimicrobial peptides as agents of mucosal immunity. Ciba Found Symp. 1994; 186:250-60; discussion 261-9. PMID: 7768155.
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    117. Diamond G, Jones DE, Bevins CL. Airway epithelial cells are the site of expression of a mammalian antimicrobial peptide gene. Proc Natl Acad Sci U S A. 1993 May 15; 90(10):4596-600. PMID: 8506305.
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    118. Jones DE, Bevins CL. Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel. FEBS Lett. 1993 Jan 04; 315(2):187-92. PMID: 8417977.
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    119. Jones DE, Bevins CL. Paneth cells of the human small intestine express an antimicrobial peptide gene. J Biol Chem. 1992 Nov 15; 267(32):23216-25. PMID: 1429669.
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    120. Sadler KC, Bevins CL, Kaltenbach JC. Localization of xenopsin and xenopsin precursor fragment immunoreactivities in the skin and gastrointestinal tract of Xenopus laevis. Cell Tissue Res. 1992 Nov; 270(2):257-63. PMID: 1451171.
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    121. Diamond G, Zasloff M, Eck H, Brasseur M, Maloy W, Bevins C. A novel antimicrobial peptide from mammalian tracheal mucosa. Chest. 1992 Mar; 101(3 Suppl):47S. PMID: 1541202.
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    122. Harsch AD, Xu J, Bevins CL, Glick MC, Scanlin TF. Preparation of isolated surface membranes from cystic fibrosis airway epithelial cells. Chest. 1992 Mar; 101(3 Suppl):58S-60S. PMID: 1371735.
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    123. Moore KS, Bevins CL, Tomassini N, Huttner KM, Sadler K, Moreira JE, Reynolds J, Zasloff M. A novel peptide-producing cell in Xenopus: multinucleated gastric mucosal cell strikingly similar to the granular gland of the skin. J Histochem Cytochem. 1992 Mar; 40(3):367-78. PMID: 1552176.
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    124. Diamond G, Scanlin TF, Zasloff MA, Bevins CL. A cross-species analysis of the cystic fibrosis transmembrane conductance regulator. Potential functional domains and regulatory sites. J Biol Chem. 1991 Nov 25; 266(33):22761-9. PMID: 1719001.
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    125. Moore KS, Bevins CL, Brasseur MM, Tomassini N, Turner K, Eck H, Zasloff M. Antimicrobial peptides in the stomach of Xenopus laevis. J Biol Chem. 1991 Oct 15; 266(29):19851-7. PMID: 1717472.
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    126. Diamond G, Zasloff M, Eck H, Brasseur M, Maloy WL, Bevins CL. Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA. Proc Natl Acad Sci U S A. 1991 May 01; 88(9):3952-6. PMID: 2023943.
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    127. Kadowaki H, Kadowaki T, Cama A, Marcus-Samuels B, Rovira A, Bevins CL, Taylor SI. Mutagenesis of lysine 460 in the human insulin receptor. Effects upon receptor recycling and cooperative interactions among binding sites. J Biol Chem. 1990 Dec 05; 265(34):21285-96. PMID: 2123490.
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    128. Wolff A, Moreira JE, Bevins CL, Hand AR, Fox PC. Magainin-like immunoreactivity in human submandibular and labial salivary glands. J Histochem Cytochem. 1990 Nov; 38(11):1531-4. PMID: 2212614.
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    129. Berkowitz BA, Bevins CL, Zasloff MA. Magainins: a new family of membrane-active host defense peptides. Biochem Pharmacol. 1990 Feb 15; 39(4):625-9. PMID: 1689576.
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    130. Taylor SI, Kadowaki T, Accili D, Cama A, Kadowaki H, McKeon C, Moncada V, Marcus-Samuels B, Bevins C, Ojamaa K. Mutations in the insulin receptor gene in genetic forms of insulin resistance. Recent Prog Horm Res. 1990; 46:185-213; discussion 213-7. PMID: 2177906.
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    131. Bevins CL, Zasloff M. Peptides from frog skin. Annu Rev Biochem. 1990; 59:395-414. PMID: 2197979.
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    132. Odawara M, Kadowaki T, Yamamoto R, Shibasaki Y, Tobe K, Accili D, Bevins C, Mikami Y, Matsuura N, Akanuma Y. Human diabetes associated with a mutation in the tyrosine kinase domain of the insulin receptor. Science. 1989 Jul 07; 245(4913):66-8. PMID: 2544998.
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    133. Serrano J, Bevins CL, Young SW, de Pablo F. Insulin gene expression in chicken ontogeny: pancreatic, extrapancreatic, and prepancreatic. Dev Biol. 1989 Apr; 132(2):410-8. PMID: 2647543.
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    134. Kadowaki T, Bevins CL, Cama A, Ojamaa K, Marcus-Samuels B, Kadowaki H, Beitz L, McKeon C, Taylor SI. Two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance. Science. 1988 May 06; 240(4853):787-90. PMID: 2834824.
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    135. Bevins CL, Pollack RM, Kayser RH, Bounds PL. Detection of a transient enzyme-steroid complex during active-site-directed irreversible inhibition of 3-oxo-delta 5-steroid isomerase. Biochemistry. 1986 Sep 09; 25(18):5159-64. PMID: 3768338.
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    136. Bantia S, Bevins CL, Pollack RM. Mechanism of inactivation of 3-oxosteroid delta 5-isomerase by 17 beta-oxiranes. Biochemistry. 1985 May 21; 24(11):2606-9. PMID: 4027215.
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    137. Kayser RH, Bounds PL, Bevins CL, Pollack RM. Affinity alkylation of bacterial delta 5-3-ketosteroid isomerase. Identification of the amino acid modified by steroidal 17 beta-oxiranes. J Biol Chem. 1983 Jan 25; 258(2):909-15. PMID: 6822514.
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    138. Bevins CL, Kayser RH, Pollack RM, Ekiko DB, Sadoff S. Irreversible active-site-directed inhibition of delta 5-3-ketosteroid isomerase by steroidal 17-beta-oxiranes. Evidence for two modes of binding in steroid-enzyme complexes. Biochem Biophys Res Commun. 1980 Aug 14; 95(3):1131-7. PMID: 7417304.
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    139. Bevins CL, Bashirelahi N. Stabilization of 8S progesterone receptor from human prostate in the presence of molybdate ion. Cancer Res. 1980 Jul; 40(7):2234-9. PMID: 7190061.
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    140. Pollack RM, Kayser RH, Bevins CL. An active-site-directed irreversible inhibitor of delta 5-3-ketosteroid isomerase. Biochem Biophys Res Commun. 1979 Dec 14; 91(3):783-90. PMID: 526282.
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