Paul A Luciw

Title(s)Professor Emeritus, Pathology and Laboratory Medicine
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    Collapse Research 
    Collapse Research Activities and Funding
    Novel Immunoassays for Mycobacteria Detection in Non-human Primates
    NIH/NCRR R24RR022907Sep 1, 2006 - Jul 31, 2010
    Role: Principal Investigator
    Multiplex Analysis of AIDS by Laser Scanning Cytometry
    NIH/NIAID R03AI054202Sep 15, 2002 - Sep 14, 2004
    Role: Principal Investigator
    NIH/NCRR S10RR012964Apr 1, 1998 - Mar 31, 1999
    Role: Principal Investigator
    NIH/NIAID R21AI042608Sep 30, 1997 - Sep 29, 1999
    Role: Principal Investigator
    NIH/NIAID R01AI041907Jul 15, 1997 - Jun 30, 2001
    Role: Principal Investigator
    NIH/NIAID R01AI038532Aug 1, 1995 - Jul 31, 2004
    Role: Principal Investigator
    NIH/NIAID R01AI034772Jun 30, 1993 - Jun 30, 1997
    Role: Principal Investigator
    NIH/NIAID R01AI030525Jul 1, 1992 - Apr 30, 1997
    Role: Principal Investigator
    NIH/NIAID R01AI028580Jul 1, 1989 - Jun 30, 1994
    Role: Principal Investigator
    NIH/NHLBI R01HL043609Jul 1, 1989 - Jun 30, 1994
    Role: Principal Investigator
    NIH/NIAID R01AI025109Sep 15, 1987 - Aug 31, 1990
    Role: Principal Investigator
    NIH/NIAID R43AI022778Aug 1, 1985 - Jan 31, 1986
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Srinivas N, Joseph SB, Robertson K, Kincer LP, Menezes P, Adamson L, Schauer AP, Blake KH, White N, Sykes C, Luciw P, Eron JJ, Forrest A, Price R, Spudich S, Swanstrom R, Kashuba AD. Predicting efavirenz concentrations in the brain tissue of HIV-infected individuals and exploring their relationship to neurocognitive impairment. Clin Transl Sci. 2019 Jan 24. PMID: 30675981.
      View in: PubMed
    2. Srinivas N, Rosen EP, Gilliland WM, Kovarova M, Remling-Mulder L, De La Cruz G, White N, Adamson L, Schauer AP, Sykes C, Luciw P, Garcia JV, Akkina R, Kashuba ADM. Antiretroviral concentrations and surrogate measures of efficacy in the brain tissue and CSF of preclinical species. Xenobiotica. 2018 Dec 17; 1-10. PMID: 30346892.
      View in: PubMed
    3. Almodovar S, Swanson J, Giavedoni LD, Kanthaswamy S, Long CS, Voelkel NF, Edwards MG, Folkvord JM, Connick E, Westmoreland SV, Luciw PA, Flores SC. Lung Vascular Remodeling, Cardiac Hypertrophy, and Inflammatory Cytokines in SHIVnef-Infected Macaques. Viral Immunol. 2018 04; 31(3):206-222. PMID: 29256819.
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    4. Shete PB, Ravindran R, Chang E, Worodria W, Chaisson LH, Andama A, Davis JL, Luciw PA, Huang L, Khan IH, Cattamanchi A. Evaluation of antibody responses to panels of M. tuberculosis antigens as a screening tool for active tuberculosis in Uganda. PLoS One. 2017; 12(8):e0180122. PMID: 28767658.
      View in: PubMed
    5. Thompson CG, Fallon JK, Mathews M, Charlins P, Remling-Mulder L, Kovarova M, Adamson L, Srinivas N, Schauer A, Sykes C, Luciw P, Garcia JV, Akkina R, Smith PC, Kashuba ADM. Multimodal analysis of drug transporter expression in gastrointestinal tissue. AIDS. 2017 07 31; 31(12):1669-1678. PMID: 28590331.
      View in: PubMed
    6. Keestra-Gounder AM, Byndloss MX, Seyffert N, Young BM, Chávez-Arroyo A, Tsai AY, Cevallos SA, Winter MG, Pham OH, Tiffany CR, de Jong MF, Kerrinnes T, Ravindran R, Luciw PA, McSorley SJ, Bäumler AJ, Tsolis RM. NOD1 and NOD2 signalling links ER stress with inflammation. Nature. 2016 Apr 21; 532(7599):394-7. PMID: 27007849.
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    7. Thompson CG, Bokhart MT, Sykes C, Adamson L, Fedoriw Y, Luciw PA, Muddiman DC, Kashuba AD, Rosen EP. Mass spectrometry imaging reveals heterogeneous efavirenz distribution within putative HIV reservoirs. Antimicrob Agents Chemother. 2015 May; 59(5):2944-8. PMID: 25733502.
      View in: PubMed
    8. Mani A, Ravindran R, Mannepalli S, Vang D, Luciw PA, Hogarth M, Khan IH, Krishnan VV. Data mining strategies to improve multiplex microbead immunoassay tolerance in a mouse model of infectious diseases. PLoS One. 2015; 10(1):e0116262. PMID: 25614982; PMCID: PMC4304816.
    9. North TW, Villalobos A, Hurwitz SJ, Deere JD, Higgins J, Chatterjee P, Tao S, Kauffman RC, Luciw PA, Kohler JJ, Schinazi RF. Enhanced antiretroviral therapy in rhesus macaques improves RT-SHIV viral decay kinetics. Antimicrob Agents Chemother. 2014 Jul; 58(7):3927-33. PMID: 24777106.
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    10. Krishnan VV, Ravindran R, Wun T, Luciw PA, Khan IH, Janatpour K. Multiplexed measurements of immunomodulator levels in peripheral blood of healthy subjects: Effects of analytical variables based on anticoagulants, age, and gender. Cytometry B Clin Cytom. 2014 Nov; 86(6):426-35. PMID: 24574151.
      View in: PubMed
    11. Chromy BA, Eldridge A, Forsberg JA, Brown TS, Kirkup BC, Elster E, Luciw P. Proteomic sample preparation for blast wound characterization. Proteome Sci. 2014 Feb 14; 12(1):10. PMID: 24529238; PMCID: PMC3943455.
    12. Deere JD, Kauffman RC, Cannavo E, Higgins J, Villalobos A, Adamson L, Schinazi RF, Luciw PA, North TW. Analysis of multiply spliced transcripts in lymphoid tissue reservoirs of rhesus macaques infected with RT-SHIV during HAART. PLoS One. 2014; 9(2):e87914. PMID: 24505331; PMCID: PMC3914874.
    13. Ravindran R, Krishnan VV, Dhawan R, Wunderlich ML, Lerche NW, Flynn JL, Luciw PA, Khan IH. Plasma antibody profiles in non-human primate tuberculosis. J Med Primatol. 2014 Apr; 43(2):59-71. PMID: 24446897.
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    14. Chromy BA, Eldridge A, Forsberg JA, Brown TS, Kirkup BC, Jaing C, Be NA, Elster E, Luciw PA. Wound outcome in combat injuries is associated with a unique set of protein biomarkers. J Transl Med. 2013 Nov 06; 11:281. PMID: 24192341; PMCID: PMC3827499.
    15. Xavier MN, Winter MG, Spees AM, den Hartigh AB, Nguyen K, Roux CM, Silva TM, Atluri VL, Kerrinnes T, Keestra AM, Monack DM, Luciw PA, Eigenheer RA, Bäumler AJ, Santos RL, Tsolis RM. PPAR?-mediated increase in glucose availability sustains chronic Brucella abortus infection in alternatively activated macrophages. Cell Host Microbe. 2013 Aug 14; 14(2):159-70. PMID: 23954155; PMCID: PMC3777723.
    16. Ravindran R, Krishnan VV, Khanum A, Luciw PA, Khan IH. Exploratory study on plasma immunomodulator and antibody profiles in tuberculosis patients. Clin Vaccine Immunol. 2013 Aug; 20(8):1283-90. PMID: 23761664; PMCID: PMC3754529.
    17. McDonnel SJ, Sparger EE, Luciw PA, Murphy BG. Pharmacologic reactivation of latent feline immunodeficiency virus ex vivo in peripheral CD4+ T-lymphocytes. Virus Res. 2012 Dec; 170(1-2):174-9. PMID: 23073179; PMCID: PMC3513637.
    18. Schunter M, Chu H, Hayes TL, McConnell D, Crawford SS, Luciw PA, Bengmark S, Asmuth DM, Brown J, Bevins CL, Shacklett BL, Critchfield JW. Randomized pilot trial of a synbiotic dietary supplement in chronic HIV-1 infection. BMC Complement Altern Med. 2012 Jun 29; 12:84. PMID: 22747752; PMCID: PMC3414771.
    19. Jensen K, Ranganathan UD, Van Rompay KK, Canfield DR, Khan I, Ravindran R, Luciw PA, Jacobs WR, Fennelly G, Larsen MH, Abel K. A recombinant attenuated Mycobacterium tuberculosis vaccine strain is safe in immunosuppressed simian immunodeficiency virus-infected infant macaques. Clin Vaccine Immunol. 2012 Aug; 19(8):1170-81. PMID: 22695156; PMCID: PMC3416096.
    20. McDonnel SJ, Sparger EE, Luciw PA, Murphy BG. Transcriptional regulation of latent feline immunodeficiency virus in peripheral CD4+ T-lymphocytes. Viruses. 2012 05; 4(5):878-88. PMID: 22754653; PMCID: PMC3386631.
    21. Murphy B, Vapniarsky N, Hillman C, Castillo D, McDonnel S, Moore P, Luciw PA, Sparger EE. FIV establishes a latent infection in feline peripheral blood CD4+ T lymphocytes in vivo during the asymptomatic phase of infection. Retrovirology. 2012 Feb 07; 9:12. PMID: 22314004; PMCID: PMC3292463.
    22. Campbell M, Chang PC, Huerta S, Izumiya C, Davis R, Tepper CG, Kim KY, Shevchenko B, Wang DH, Jung JU, Luciw PA, Kung HJ, Izumiya Y. Protein arginine methyltransferase 1-directed methylation of Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen. J Biol Chem. 2012 Feb 17; 287(8):5806-18. PMID: 22179613; PMCID: PMC3285351.
    23. Khan IH, Ravindran R, Krishnan VV, Awan IN, Rizvi SK, Saqib MA, Shahzad MI, Tahseen S, Ireton G, Goulding CW, Felgner P, DeRiemer K, Khanum A, Luciw PA. Plasma antibody profiles as diagnostic biomarkers for tuberculosis. Clin Vaccine Immunol. 2011 Dec; 18(12):2148-53. PMID: 21976221; PMCID: PMC3232686.
    24. Luciw PA, Oslund KL, Yang XW, Adamson L, Ravindran R, Canfield DR, Tarara R, Hirst L, Christensen M, Lerche NW, Offenstein H, Lewinsohn D, Ventimiglia F, Brignolo L, Wisner ER, Hyde DM. Stereological analysis of bacterial load and lung lesions in nonhuman primates (rhesus macaques) experimentally infected with Mycobacterium tuberculosis. Am J Physiol Lung Cell Mol Physiol. 2011 Nov; 301(5):L731-8. PMID: 21873450; PMCID: PMC3213984.
    25. Chen CI, Clark DC, Pesavento P, Lerche NW, Luciw PA, Reisen WK, Brault AC. Comparative pathogenesis of epidemic and enzootic Chikungunya viruses in a pregnant Rhesus macaque model. Am J Trop Med Hyg. 2010 Dec; 83(6):1249-58. PMID: 21118930; PMCID: PMC2990040.
    26. Ravindran R, Khan IH, Krishnan VV, Ziman M, Kendall LV, Frasier JM, Bates R, Griffey SM, Fahey JR, Luciw PA. Validation of multiplex microbead immunoassay for simultaneous serodetection of multiple infectious agents in laboratory mouse. J Immunol Methods. 2010 Dec 15; 363(1):51-9. PMID: 20965193.
      View in: PubMed
    27. Campbell M, Lie WR, Zhao J, Hayes D, Mistry J, Kung HJ, Luciw PA, Khan IH. Multiplex analysis of Src family kinase signaling by microbead suspension arrays. Assay Drug Dev Technol. 2010 Aug; 8(4):488-96. PMID: 20482378.
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    28. Deere JD, Higgins J, Cannavo E, Villalobos A, Adamson L, Fromentin E, Schinazi RF, Luciw PA, North TW. Viral decay kinetics in the highly active antiretroviral therapy-treated rhesus macaque model of AIDS. PLoS One. 2010 Jul 23; 5(7):e11640. PMID: 20668516; PMCID: PMC2909142.
    29. Khan IH, Zhao J, Ghosh P, Ziman M, Sweeney C, Kung HJ, Luciw PA. Microbead arrays for the analysis of ErbB receptor tyrosine kinase activation and dimerization in breast cancer cells. Assay Drug Dev Technol. 2010 Feb; 8(1):27-36. PMID: 20035613; PMCID: PMC3196214.
    30. Chang PC, Izumiya Y, Wu CY, Fitzgerald LD, Campbell M, Ellison TJ, Lam KS, Luciw PA, Kung HJ. Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a SUMO E3 ligase that is SIM-dependent and SUMO-2/3-specific. J Biol Chem. 2010 Feb 19; 285(8):5266-73. PMID: 20034935; PMCID: PMC2820755.
    31. North TW, Higgins J, Deere JD, Hayes TL, Villalobos A, Adamson L, Shacklett BL, Schinazi RF, Luciw PA. Viral sanctuaries during highly active antiretroviral therapy in a nonhuman primate model for AIDS. J Virol. 2010 Mar; 84(6):2913-22. PMID: 20032180; PMCID: PMC2826073.
    32. Jesus da Costa L, Lopes Dos Santos A, Mandic R, Shaw K, Santana de Aguiar R, Tanuri A, Luciw PA, Peterlin BM. Interactions between SIVNef, SIVGagPol and Alix correlate with viral replication and progression to AIDS in rhesus macaques. Virology. 2009 Nov 10; 394(1):47-56. PMID: 19748111; PMCID: PMC2767429.
    33. Khan IH, Krishnan VV, Ziman M, Janatpour K, Wun T, Luciw PA, Tuscano J. A comparison of multiplex suspension array large-panel kits for profiling cytokines and chemokines in rheumatoid arthritis patients. Cytometry B Clin Cytom. 2009 May; 76(3):159-68. PMID: 18823005; PMCID: PMC4425447.
    34. Ellison TJ, Izumiya Y, Izumiya C, Luciw PA, Kung HJ. A comprehensive analysis of recruitment and transactivation potential of K-Rta and K-bZIP during reactivation of Kaposi's sarcoma-associated herpesvirus. Virology. 2009 Apr 25; 387(1):76-88. PMID: 19269659; PMCID: PMC4327937.
    35. Dubie RA, Maksaereekul S, Shacklett BL, Lemongello D, Cole KS, Villinger F, Blozis SA, Luciw PA, Sparger EE. Co-immunization with IL-15 enhances cellular immune responses induced by a vif-deleted simian immunodeficiency virus proviral DNA vaccine and confers partial protection against vaginal challenge with SIVmac251. Virology. 2009 Mar 30; 386(1):109-21. PMID: 19193388; PMCID: PMC3640844.
    36. Sparger EE, Dubie RA, Shacklett BL, Cole KS, Chang WL, Luciw PA. Vaccination of rhesus macaques with a vif-deleted simian immunodeficiency virus proviral DNA vaccine. Virology. 2008 May 10; 374(2):261-72. PMID: 18261756; PMCID: PMC2519864.
    37. Gardner MB, Luciw PA. Macaque models of human infectious disease. ILAR J. 2008; 49(2):220-55. PMID: 18323583.
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    38. Khan IH, Ravindran R, Yee J, Ziman M, Lewinsohn DM, Gennaro ML, Flynn JL, Goulding CW, DeRiemer K, Lerche NW, Luciw PA. Profiling antibodies to Mycobacterium tuberculosis by multiplex microbead suspension arrays for serodiagnosis of tuberculosis. Clin Vaccine Immunol. 2008 Mar; 15(3):433-8. PMID: 18077619; PMCID: PMC2268277.
    39. Gupta S, Zhou F, Greer CE, Legg H, Tang T, Luciw P, zur Megede J, Barnett SW, Donnelly JJ, O'Hagan DT, Polo JM, Vajdy M. Antibody responses against HIV in rhesus macaques following combinations of mucosal and systemic immunizations with chimeric alphavirus-based replicon particles. AIDS Res Hum Retroviruses. 2006 Oct; 22(10):993-7. PMID: 17067269.
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    40. Marecki JC, Cool CD, Parr JE, Beckey VE, Luciw PA, Tarantal AF, Carville A, Shannon RP, Cota-Gomez A, Tuder RM, Voelkel NF, Flores SC. HIV-1 Nef is associated with complex pulmonary vascular lesions in SHIV-nef-infected macaques. Am J Respir Crit Care Med. 2006 Aug 15; 174(4):437-45. PMID: 16728715; PMCID: PMC2648120.
    41. Khan IH, Mendoza S, Yee J, Deane M, Venkateswaran K, Zhou SS, Barry PA, Lerche NW, Luciw PA. Simultaneous detection of antibodies to six nonhuman-primate viruses by multiplex microbead immunoassay. Clin Vaccine Immunol. 2006 Jan; 13(1):45-52. PMID: 16425999; PMCID: PMC1356626.
    42. Khan IH, Mendoza S, Rhyne P, Ziman M, Tuscano J, Eisinger D, Kung HJ, Luciw PA. Multiplex analysis of intracellular signaling pathways in lymphoid cells by microbead suspension arrays. Mol Cell Proteomics. 2006 Apr; 5(4):758-68. PMID: 16369048.
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    43. Marecki J, Cool C, Voelkel N, Luciw P, Flores S. Evidence for vascular remodeling in the lungs of macaques infected with simian immunodeficiency virus/HIV NEF recombinant virus. Chest. 2005 Dec; 128(6 Suppl):621S-622S. PMID: 16373878.
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    44. Lian Y, Srivastava I, Gómez-Román VR, Zur Megede J, Sun Y, Kan E, Hilt S, Engelbrecht S, Himathongkham S, Luciw PA, Otten G, Ulmer JB, Donnelly JJ, Rabussay D, Montefiori D, van Rensburg EJ, Barnett SW. Evaluation of envelope vaccines derived from the South African subtype C human immunodeficiency virus type 1 TV1 strain. J Virol. 2005 Nov; 79(21):13338-49. PMID: 16227256; PMCID: PMC1262580.
    45. Gupta S, Janani R, Bin Q, Luciw P, Greer C, Perri S, Legg H, Donnelly J, Barnett S, O'Hagan D, Polo JM, Vajdy M. Characterization of human immunodeficiency virus Gag-specific gamma interferon-expressing cells following protective mucosal immunization with alphavirus replicon particles. J Virol. 2005 Jun; 79(11):7135-45. PMID: 15890953; PMCID: PMC1112144.
    46. Khan IH, Kendall LV, Ziman M, Wong S, Mendoza S, Fahey J, Griffey SM, Barthold SW, Luciw PA. Simultaneous serodetection of 10 highly prevalent mouse infectious pathogens in a single reaction by multiplex analysis. Clin Diagn Lab Immunol. 2005 Apr; 12(4):513-9. PMID: 15817759; PMCID: PMC1074384.
    47. Feng S, Kendall LV, Hodzic E, Wong S, Lorenzana E, Freet K, Ku KS, Luciw PA, Barthold SW, Khan IH. Recombinant Helicobacter bilis protein P167 for mouse serodiagnosis in a multiplex microbead assay. Clin Diagn Lab Immunol. 2004 Nov; 11(6):1094-9. PMID: 15539512; PMCID: PMC524761.
    48. Vajdy M, Singh M, Kazzaz J, Soenawan E, Ugozzoli M, Zhou F, Srivastava I, Bin Q, Barnett S, Donnelly J, Luciw P, Adamson L, Montefiori D, O'Hagan DT. Mucosal and systemic anti-HIV responses in rhesus macaques following combinations of intranasal and parenteral immunizations. AIDS Res Hum Retroviruses. 2004 Nov; 20(11):1269-81. PMID: 15588349.
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    49. Hamza MS, Reyes RA, Izumiya Y, Wisdom R, Kung HJ, Luciw PA. ORF36 protein kinase of Kaposi's sarcoma herpesvirus activates the c-Jun N-terminal kinase signaling pathway. J Biol Chem. 2004 Sep 10; 279(37):38325-30. PMID: 15247271.
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    50. Dunn SJ, Khan IH, Chan UA, Scearce RL, Melara CL, Paul AM, Sharma V, Bih FY, Holzmayer TA, Luciw PA, Abo A. Identification of cell surface targets for HIV-1 therapeutics using genetic screens. Virology. 2004 Apr 10; 321(2):260-73. PMID: 15051386.
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    51. Reyes RA, Canfield DR, Esser U, Adamson LA, Brown CR, Cheng-Mayer C, Gardner MB, Harouse JM, Luciw PA. Induction of simian AIDS in infant rhesus macaques infected with CCR5- or CXCR4-utilizing simian-human immunodeficiency viruses is associated with distinct lesions of the thymus. J Virol. 2004 Feb; 78(4):2121-30. PMID: 14747577; PMCID: PMC369416.
    52. Shacklett BL, Shaw KE, Adamson LA, Wilkens DT, Cox CA, Montefiori DC, Gardner MB, Sonigo P, Luciw PA. Live, attenuated simian immunodeficiency virus SIVmac-M4, with point mutations in the Env transmembrane protein intracytoplasmic domain, provides partial protection from mucosal challenge with pathogenic SIVmac251. J Virol. 2002 Nov; 76(22):11365-78. PMID: 12388697; PMCID: PMC136751.
    53. Lin SF, Robinson DR, Oh J, Jung JU, Luciw PA, Kung HJ. Identification of the bZIP and Rta homologues in the genome of rhesus monkey rhadinovirus. Virology. 2002 Jul 05; 298(2):181-8. PMID: 12127781.
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    54. Himathongkham S, Douglas GC, Fang A, Yu E, Barnett SW, Luciw PA. Species tropism of chimeric SHIV clones containing HIV-1 subtype-A and subtype-E envelope genes. Virology. 2002 Jul 05; 298(2):189-99. PMID: 12127782.
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    55. Luciw PA, Mandell CP, Himathongkham S, Li J, Low TA, Schmidt KA, Shaw KE, Cheng-Mayer C. Fatal immunopathogenesis by SIV/HIV-1 (SHIV) containing a variant form of the HIV-1SF33 env gene in juvenile and newborn rhesus macaques. Virology. 1999 Oct 10; 263(1):112-27. PMID: 10544087.
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