June X Zou

Title(s)Professional Researcher, Biochemistry and Molecular Medicine
SchoolSchool of Medicine
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tumor mitochondrial oxidative phosphorylation stimulated by the nuclear receptor RORγ represents an effective therapeutic opportunity in osteosarcoma. Cell Rep Med. 2024 May 21; 5(5):101519. Zheng J, Wang Q, Chen J, Cai G, Zhang Z, Zou H, Zou JX, Liu Q, Ji S, Shao G, Li H, Li S, Chen HW, Lu L, Yuan Y, Liu P, Wang J. PMID: 38692271; PMCID: PMC11148566.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Application of machine learning methods to pathogen safety evaluation in biological manufacturing processes. Biotechnol Prog. 2021 05; 37(3):e3135. Panjwani S, Cui I, Spetsieris K, Mleczko M, Wang W, Zou JX, Anwaruzzaman M, Liu S, Canales R, Hesse O. PMID: 33527773; PMCID: PMC8365771.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    3. S-adenosylhomocysteine (AdoHcy)-dependent methyltransferase inhibitor DZNep overcomes breast cancer tamoxifen resistance via induction of NSD2 degradation and suppression of NSD2-driven redox homeostasis. Chem Biol Interact. 2020 Feb 01; 317:108965. Wang Q, Zheng J, Zou JX, Xu J, Han F, Xiang S, Liu P, Chen HW, Wang J. PMID: 32001260.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    4. RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype. Nat Commun. 2019 10 11; 10(1):4621. Cai D, Wang J, Gao B, Li J, Wu F, Zou JX, Xu J, Jiang Y, Zou H, Huang Z, Borowsky AD, Bold RJ, Lara PN, Li JJ, Chen X, Lam KS, To KF, Kung HJ, Fiehn O, Zhao R, Evans RM, Chen HW. PMID: 31604910; PMCID: PMC6789042.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    5. Histone methyltransferase NSD2 mediates the survival and invasion of triple-negative breast cancer cells via stimulating ADAM9-EGFR-AKT signaling. Acta Pharmacol Sin. 2019 Aug; 40(8):1067-1075. Wang JJ, Zou JX, Wang H, Duan ZJ, Wang HB, Chen P, Liu PQ, Xu JZ, Chen HW. PMID: 30670815; PMCID: PMC6786427.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    6. KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC. Oncogene. 2019 01; 38(1):17-32. Wang HJ, Pochampalli M, Wang LY, Zou JX, Li PS, Hsu SC, Wang BJ, Huang SH, Yang P, Yang JC, Chu CY, Hsieh CL, Sung SY, Li CF, Tepper CG, Ann DK, Gao AC, Evans CP, Izumiya Y, Chuu CP, Wang WC, Chen HW, Kung HJ. PMID: 30072740; PMCID: PMC6755995.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    7. Silencing the epigenetic silencer KDM4A for TRAIL and DR5 simultaneous induction and antitumor therapy. Cell Death Differ. 2016 11 01; 23(11):1886-1896. Wang J, Wang H, Wang LY, Cai D, Duan Z, Zhang Y, Chen P, Zou JX, Xu J, Chen X, Kung HJ, Chen HW. PMID: 27612013; PMCID: PMC5071577.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    8. Corrigendum: ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. Nat Med. 2016 06 07; 22(6):692. Wang J, Zou JX, Xue X, Cai D, Zhang Y, Duan Z, Xiang Q, Yang JC, Louie MC, Borowsky AD, Gao AC, Evans CP, Lam KS, Xu J, Kung HJ, Evans RM, Xu Y, Chen HW. PMID: 27270780.
      View in: PubMed   Mentions: 5     Fields:    
    9. Reprogramming metabolism by histone methyltransferase NSD2 drives endocrine resistance via coordinated activation of pentose phosphate pathway enzymes. Cancer Lett. 2016 08 10; 378(2):69-79. Wang J, Duan Z, Nugent Z, Zou JX, Borowsky AD, Zhang Y, Tepper CG, Li JJ, Fiehn O, Xu J, Kung HJ, Murphy LC, Chen HW. PMID: 27164560; PMCID: PMC7505026.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    10. ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. Nat Med. 2016 05; 22(5):488-96. Wang J, Zou JX, Xue X, Cai D, Zhang Y, Duan Z, Xiang Q, Yang JC, Louie MC, Borowsky AD, Gao AC, Evans CP, Lam KS, Xu J, Kung HJ, Evans RM, Xu Y, Chen HW. PMID: 27019329; PMCID: PMC5030109.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    11. ATAD2 overexpression links to enrichment of B-MYB-translational signatures and development of aggressive endometrial carcinoma. Oncotarget. 2015 Sep 29; 6(29):28440-52. Krakstad C, Tangen IL, Hoivik EA, Halle MK, Berg A, Werner HM, Ræder MB, Kusonmano K, Zou JX, Øyan AM, Stefansson I, Trovik J, Kalland KH, Chen HW, Salvesen HB. PMID: 26308378; PMCID: PMC4695070.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    12. CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance. Mol Cancer Ther. 2015 Sep; 14(9):2090-102. Liu R, Fan M, Candas D, Qin L, Zhang X, Eldridge A, Zou JX, Zhang T, Juma S, Jin C, Li RF, Perks J, Sun LQ, Vaughan AT, Hai CX, Gius DR, Li JJ. PMID: 26141949; PMCID: PMC4560959.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    13. Transporting Cells in Semi-Solid Gel Condition and at Ambient Temperature. PLoS One. 2015; 10(6):e0128229. Wang J, Chen P, Xu J, Zou JX, Wang H, Chen HW. PMID: 26098554; PMCID: PMC4476595.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    14. Estrogen-related receptor alpha confers methotrexate resistance via attenuation of reactive oxygen species production and P53 mediated apoptosis in osteosarcoma cells. Biomed Res Int. 2014; 2014:616025. Chen P, Wang H, Duan Z, Zou JX, Chen H, He W, Wang J. PMID: 24967384; PMCID: PMC4055217.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    15. Kinesin family deregulation coordinated by bromodomain protein ANCCA and histone methyltransferase MLL for breast cancer cell growth, survival, and tamoxifen resistance. Mol Cancer Res. 2014 Apr; 12(4):539-49. Zou JX, Duan Z, Wang J, Sokolov A, Xu J, Chen CZ, Li JJ, Chen HW. PMID: 24391143; PMCID: PMC4139106.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCells
    16. Developmental and androgenic regulation of chromatin regulators EZH2 and ANCCA/ATAD2 in the prostate Via MLL histone methylase complex. Prostate. 2013 Apr; 73(5):455-66. Duan Z, Zou JX, Yang P, Wang Y, Borowsky AD, Gao AC, Chen HW. PMID: 23038103.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    17. Histone methyltransferase NSD2/MMSET mediates constitutive NF-κB signaling for cancer cell proliferation, survival, and tumor growth via a feed-forward loop. Mol Cell Biol. 2012 Aug; 32(15):3121-31. Yang P, Guo L, Duan ZJ, Tepper CG, Xue L, Chen X, Kung HJ, Gao AC, Zou JX, Chen HW. PMID: 22645312; PMCID: PMC3434505.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    18. MicroRNA let-7c is downregulated in prostate cancer and suppresses prostate cancer growth. PLoS One. 2012; 7(3):e32832. Nadiminty N, Tummala R, Lou W, Zhu Y, Shi XB, Zou JX, Chen H, Zhang J, Chen X, Luo J, deVere White RW, Kung HJ, Evans CP, Gao AC. PMID: 22479342; PMCID: PMC3316551.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    19. Nuclear receptor coregulators as a new paradigm for therapeutic targeting. Adv Drug Deliv Rev. 2010 Oct 30; 62(13):1227-37. Hsia EY, Goodson ML, Zou JX, Privalsky ML, Chen HW. PMID: 20933027; PMCID: PMC5004779.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    20. ANCCA/ATAD2 overexpression identifies breast cancer patients with poor prognosis, acting to drive proliferation and survival of triple-negative cells through control of B-Myb and EZH2. Cancer Res. 2010 Nov 15; 70(22):9402-12. Kalashnikova EV, Revenko AS, Gemo AT, Andrews NP, Tepper CG, Zou JX, Cardiff RD, Borowsky AD, Chen HW. PMID: 20864510; PMCID: PMC2982862.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansCells
    21. Chromatin loading of E2F-MLL complex by cancer-associated coregulator ANCCA via reading a specific histone mark. Mol Cell Biol. 2010 Nov; 30(22):5260-72. Revenko AS, Kalashnikova EV, Gemo AT, Zou JX, Chen HW. PMID: 20855524; PMCID: PMC2976367.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    22. Deregulated E2F and the AAA+ coregulator ANCCA drive proto-oncogene ACTR/AIB1 overexpression in breast cancer. Mol Cancer Res. 2010 Feb; 8(2):183-93. Hsia EY, Kalashnikova EV, Revenko AS, Zou JX, Borowsky AD, Chen HW. PMID: 20124470.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    23. The roles and action mechanisms of p160/SRC coactivators and the ANCCA coregulator in cancer. Prog Mol Biol Transl Sci. 2009; 87:261-98. Hsia EY, Zou JX, Chen HW. PMID: 20374707.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    24. Androgen-induced coactivator ANCCA mediates specific androgen receptor signaling in prostate cancer. Cancer Res. 2009 Apr 15; 69(8):3339-46. Zou JX, Guo L, Revenko AS, Tepper CG, Gemo AT, Kung HJ, Chen HW. PMID: 19318566.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    25. Prolonged androgen receptor loading onto chromatin and the efficient recruitment of p160 coactivators contribute to androgen-independent growth of prostate cancer cells. Prostate. 2008 Dec 01; 68(16):1816-26. Shi XB, Xue L, Zou JX, Gandour-Edwards R, Chen H, deVere White RW. PMID: 18780293.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    26. Proto-oncogene ACTR/AIB1 promotes cancer cell invasion by up-regulating specific matrix metalloproteinase expression. Cancer Lett. 2008 Mar 08; 261(1):64-73. Li LB, Louie MC, Chen HW, Zou JX. PMID: 18162290.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    27. ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18067-72. Zou JX, Revenko AS, Li LB, Gemo AT, Chen HW. PMID: 17998543; PMCID: PMC2084297.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    28. ACTR/AIB1/SRC-3 and androgen receptor control prostate cancer cell proliferation and tumor growth through direct control of cell cycle genes. Prostate. 2006 Oct 01; 66(14):1474-86. Zou JX, Zhong Z, Shi XB, Tepper CG, deVere White RW, Kung HJ, Chen H. PMID: 16921507.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    29. Direct control of cell cycle gene expression by proto-oncogene product ACTR, and its autoregulation underlies its transforming activity. Mol Cell Biol. 2006 May; 26(10):3810-23. Louie MC, Revenko AS, Zou JX, Yao J, Chen HW. PMID: 16648476; PMCID: PMC1489001.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    30. ACTR/AIB1 functions as an E2F1 coactivator to promote breast cancer cell proliferation and antiestrogen resistance. Mol Cell Biol. 2004 Jun; 24(12):5157-71. Louie MC, Zou JX, Rabinovich A, Chen HW. PMID: 15169882; PMCID: PMC419858.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansCells
    31. Androgen-induced recruitment of RNA polymerase II to a nuclear receptor-p160 coactivator complex. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2226-30. Louie MC, Yang HQ, Ma AH, Xu W, Zou JX, Kung HJ, Chen HW. PMID: 12589022; PMCID: PMC151322.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    32. Activated SRC oncogene phosphorylates R-ras and suppresses integrin activity. J Biol Chem. 2002 Jan 18; 277(3):1824-7. Zou JX, Liu Y, Pasquale EB, Ruoslahti E. PMID: 11682467.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    33. R-Ras contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-Ras. J Biol Chem. 2000 Feb 18; 275(7):5222-7. Wang B, Zou JX, Ek-Rylander B, Ruoslahti E. PMID: 10671570.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    34. An Eph receptor regulates integrin activity through R-Ras. Proc Natl Acad Sci U S A. 1999 Nov 23; 96(24):13813-8. Zou JX, Wang B, Kalo MS, Zisch AH, Pasquale EB, Ruoslahti E. PMID: 10570155; PMCID: PMC24147.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    35. The requirement for Vif of SIVmac is cell-type dependent. J Gen Virol. 1996 Mar; 77 ( Pt 3):427-34. Zou JX, Luciw PA. PMID: 8601777.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    36. The transcriptional transactivator of simian foamy virus 1 binds to a DNA target element in the viral internal promoter. Proc Natl Acad Sci U S A. 1996 Jan 09; 93(1):326-30. Zou JX, Luciw PA. PMID: 8552631; PMCID: PMC40231.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells