Hongwu Chen

Title(s)Professor, Biochemistry and Molecular Medicine
SchoolSchool of Medicine
AddressUCDMC Research 3 bldg, 4645 2nd Ave
CA 95817
Phone916-734-7743
ORCID ORCID Icon0000-0003-0177-6989 Additional info
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    Collapse Research 
    Collapse Research Activities and Funding
    Therapeutic targeting of tumor metabolism in advanced prostate cancer
    NIH I01BX004271Jan 1, 2019 - Dec 31, 2022
    Role: Principal Investigator
    Therapeutic targeting of orphan NR in ER-negative breast cancer
    NIH R01CA224900Dec 1, 2018 - Nov 30, 2023
    Role: Principal Investigator
    Targeting key orphan nuclear receptor in lethal prostate cancer
    NIH R01CA206222Mar 9, 2016 - Feb 28, 2021
    Role: Principal Investigator
    Novel Epigenetic regulators in cancer therapeutic resistance and as new targets
    NIH I01BX002237Apr 1, 2014 - Mar 31, 2018
    Role: Principal Investigator
    AR signal mediators in prostate cancer
    NIH R01CA134766Jul 20, 2009 - Jun 30, 2012
    Role: Principal Investigator
    Role of coactivators in cell growth and tumorigenesis
    NIH R01CA113860Feb 1, 2006 - Dec 31, 2011
    Role: Principal Investigator
    Nuclear cofactors in hormone signaling
    NIH R01DK060019Jul 1, 2001 - Feb 28, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Student Projects

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Targeting bromodomain protein ANCCA/ATAD2 enhances the efficacy of DNA‑damaging chemotherapy agents and radiation. Oncol Rep. 2020 01; 43(1):318-327. Duan Z, Andrews NP, Chen CZ, Fan M, Wang J, Shen J, Li JJ, Chen HW. PMID: 31789405.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    2. RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype. Nat Commun. 2019 10 11; 10(1):4621. Cai D, Wang J, Gao B, Li J, Wu F, Zou JX, Xu J, Jiang Y, Zou H, Huang Z, Borowsky AD, Bold RJ, Lara PN, Li JJ, Chen X, Lam KS, To KF, Kung HJ, Fiehn O, Zhao R, Evans RM, Chen HW. PMID: 31604910; PMCID: PMC6789042.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    3. Overexpressed ABCB1 Induces Olaparib-Taxane Cross-Resistance in Advanced Prostate Cancer. Transl Oncol. 2019 Jul; 12(7):871-878. Lombard AP, Liu C, Armstrong CM, D'Abronzo LS, Lou W, Chen H, Dall'Era M, Ghosh PM, Evans CP, Gao AC. PMID: 31075528; PMCID: PMC6510951.
      View in: PubMed   Mentions: 9  
    4. Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORγ Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer. J Med Chem. 2019 05 09; 62(9):4716-4730. Zhang Y, Wu X, Xue X, Li C, Wang J, Wang R, Zhang C, Wang C, Shi Y, Zou L, Li Q, Huang Z, Hao X, Loomes K, Wu D, Chen HW, Xu J, Xu Y. PMID: 30964293.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    5. Histone methyltransferase NSD2 mediates the survival and invasion of triple-negative breast cancer cells via stimulating ADAM9-EGFR-AKT signaling. Acta Pharmacol Sin. 2019 Aug; 40(8):1067-1075. Wang JJ, Zou JX, Wang H, Duan ZJ, Wang HB, Chen P, Liu PQ, Xu JZ, Chen HW. PMID: 30670815; PMCID: PMC6786427.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    6. Proteostasis by STUB1/HSP70 complex controls sensitivity to androgen receptor targeted therapy in advanced prostate cancer. Nat Commun. 2018 11 16; 9(1):4700. Liu C, Lou W, Yang JC, Liu L, Armstrong CM, Lombard AP, Zhao R, Noel ODV, Tepper CG, Chen HW, Dall'Era M, Evans CP, Gao AC. PMID: 30446660; PMCID: PMC6240084.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    7. KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC. Oncogene. 2019 01; 38(1):17-32. Wang HJ, Pochampalli M, Wang LY, Zou JX, Li PS, Hsu SC, Wang BJ, Huang SH, Yang P, Yang JC, Chu CY, Hsieh CL, Sung SY, Li CF, Tepper CG, Ann DK, Gao AC, Evans CP, Izumiya Y, Chuu CP, Wang WC, Chen HW, Kung HJ. PMID: 30072740; PMCID: PMC6755995.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    8. Benzoxazinone-containing 3,5-dimethylisoxazole derivatives as BET bromodomain inhibitors for treatment of castration-resistant prostate cancer. Eur J Med Chem. 2018 May 25; 152:542-559. Xue X, Zhang Y, Wang C, Zhang M, Xiang Q, Wang J, Wang A, Li C, Zhang C, Zou L, Wang R, Wu S, Lu Y, Chen H, Ding K, Li G, Xu Y. PMID: 29758518.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    9. Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC). J Med Chem. 2018 04 12; 61(7):3037-3058. Zhang M, Zhang Y, Song M, Xue X, Wang J, Wang C, Zhang C, Li C, Xiang Q, Zou L, Wu X, Wu C, Dong B, Xue W, Zhou Y, Chen H, Wu D, Ding K, Xu Y. PMID: 29566488.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    10. Bioengineered Noncoding RNAs Selectively Change Cellular miRNome Profiles for Cancer Therapy. J Pharmacol Exp Ther. 2018 06; 365(3):494-506. Ho PY, Duan Z, Batra N, Jilek JL, Tu MJ, Qiu JX, Hu Z, Wun T, Lara PN, DeVere White RW, Chen HW, Yu AM. PMID: 29602831; PMCID: PMC5931433.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    11. KDM4A Coactivates E2F1 to Regulate the PDK-Dependent Metabolic Switch between Mitochondrial Oxidation and Glycolysis. Cell Rep. 2016 09 13; 16(11):3016-3027. Wang LY, Hung CL, Chen YR, Yang JC, Wang J, Campbell M, Izumiya Y, Chen HW, Wang WC, Ann DK, Kung HJ. PMID: 27626669; PMCID: PMC5024724.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    12. Silencing the epigenetic silencer KDM4A for TRAIL and DR5 simultaneous induction and antitumor therapy. Cell Death Differ. 2016 11 01; 23(11):1886-1896. Wang J, Wang H, Wang LY, Cai D, Duan Z, Zhang Y, Chen P, Zou JX, Xu J, Chen X, Kung HJ, Chen HW. PMID: 27612013; PMCID: PMC5071577.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    13. Curcumin Promotes Osteosarcoma Cell Death by Activating miR-125a/ERRα Signal Pathway. J Cell Biochem. 2017 01; 118(1):74-81. Chen P, Wang H, Yang F, Chen H, He W, Wang J. PMID: 27231954.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    14. Reprogramming metabolism by histone methyltransferase NSD2 drives endocrine resistance via coordinated activation of pentose phosphate pathway enzymes. Cancer Lett. 2016 08 10; 378(2):69-79. Wang J, Duan Z, Nugent Z, Zou JX, Borowsky AD, Zhang Y, Tepper CG, Li JJ, Fiehn O, Xu J, Kung HJ, Murphy LC, Chen HW. PMID: 27164560; PMCID: PMC7505026.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    15. ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. Nat Med. 2016 05; 22(5):488-96. Wang J, Zou JX, Xue X, Cai D, Zhang Y, Duan Z, Xiang Q, Yang JC, Louie MC, Borowsky AD, Gao AC, Evans CP, Lam KS, Xu J, Kung HJ, Evans RM, Xu Y, Chen HW. PMID: 27019329; PMCID: PMC5030109.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    16. ATAD2 overexpression links to enrichment of B-MYB-translational signatures and development of aggressive endometrial carcinoma. Oncotarget. 2015 Sep 29; 6(29):28440-52. Krakstad C, Tangen IL, Hoivik EA, Halle MK, Berg A, Werner HM, Ræder MB, Kusonmano K, Zou JX, Øyan AM, Stefansson I, Trovik J, Kalland KH, Chen HW, Salvesen HB. PMID: 26308378; PMCID: PMC4695070.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    17. Transporting Cells in Semi-Solid Gel Condition and at Ambient Temperature. PLoS One. 2015; 10(6):e0128229. Wang J, Chen P, Xu J, Zou JX, Wang H, Chen HW. PMID: 26098554; PMCID: PMC4476595.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    18. LDL Receptor-Related Protein 6 Modulates Ret Proto-Oncogene Signaling in Renal Development and Cystic Dysplasia. J Am Soc Nephrol. 2016 Feb; 27(2):417-27. Wang Y, Stokes A, Duan Z, Hui J, Xu Y, Chen Y, Chen HW, Lam K, Zhou CJ. PMID: 26047795; PMCID: PMC4731110.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    19. JMJD5 interacts with p53 and negatively regulates p53 function in control of cell cycle and proliferation. Biochim Biophys Acta. 2015 Oct; 1853(10 Pt A):2286-95. Huang X, Zhang S, Qi H, Wang Z, Chen HW, Shao J, Shen J. PMID: 26025680.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    20. A long noncoding RNA connects c-Myc to tumor metabolism. Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52):18697-702. Hung CL, Wang LY, Yu YL, Chen HW, Srivastava S, Petrovics G, Kung HJ. PMID: 25512540; PMCID: PMC4284533.
      View in: PubMed   Mentions: 166     Fields:    Translation:HumansCells
    21. Estrogen-related receptor alpha confers methotrexate resistance via attenuation of reactive oxygen species production and P53 mediated apoptosis in osteosarcoma cells. Biomed Res Int. 2014; 2014:616025. Chen P, Wang H, Duan Z, Zou JX, Chen H, He W, Wang J. PMID: 24967384; PMCID: PMC4055217.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    22. Kinesin family deregulation coordinated by bromodomain protein ANCCA and histone methyltransferase MLL for breast cancer cell growth, survival, and tamoxifen resistance. Mol Cancer Res. 2014 Apr; 12(4):539-49. Zou JX, Duan Z, Wang J, Sokolov A, Xu J, Chen CZ, Li JJ, Chen HW. PMID: 24391143; PMCID: PMC4139106.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansCells
    23. Pax6 mediates ß-catenin signaling for self-renewal and neurogenesis by neocortical radial glial stem cells. Stem Cells. 2014 Jan; 32(1):45-58. Gan Q, Lee A, Suzuki R, Yamagami T, Stokes A, Nguyen BC, Pleasure D, Wang J, Chen HW, Zhou CJ. PMID: 24115331; PMCID: PMC3963407.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    24. Lin28 promotes growth of prostate cancer cells and activates the androgen receptor. Am J Pathol. 2013 Jul; 183(1):288-95. Tummala R, Nadiminty N, Lou W, Zhu Y, Gandour-Edwards R, Chen HW, Evans CP, Gao AC. PMID: 23790802; PMCID: PMC3702743.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    25. Phylogenetic analysis, expression patterns, and transcriptional regulation of human CTEN gene. Gene. 2013 May 15; 520(2):90-7. Chen NT, Kuwabara Y, Conley C, Liao YC, Hong SY, Chen M, Shih YP, Chen HW, Hsieh F, Lo SH. PMID: 23500447; PMCID: PMC3627739.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    26. Developmental and androgenic regulation of chromatin regulators EZH2 and ANCCA/ATAD2 in the prostate Via MLL histone methylase complex. Prostate. 2013 Apr; 73(5):455-66. Duan Z, Zou JX, Yang P, Wang Y, Borowsky AD, Gao AC, Chen HW. PMID: 23038103.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    27. p53, a target of estrogen receptor (ER) α, modulates DNA damage-induced growth suppression in ER-positive breast cancer cells. J Biol Chem. 2012 Aug 31; 287(36):30117-27. Berger CE, Qian Y, Liu G, Chen H, Chen X. PMID: 22787161; PMCID: PMC3436267.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    28. Histone methyltransferase NSD2/MMSET mediates constitutive NF-κB signaling for cancer cell proliferation, survival, and tumor growth via a feed-forward loop. Mol Cell Biol. 2012 Aug; 32(15):3121-31. Yang P, Guo L, Duan ZJ, Tepper CG, Xue L, Chen X, Kung HJ, Gao AC, Zou JX, Chen HW. PMID: 22645312; PMCID: PMC3434505.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    29. MicroRNA let-7c is downregulated in prostate cancer and suppresses prostate cancer growth. PLoS One. 2012; 7(3):e32832. Nadiminty N, Tummala R, Lou W, Zhu Y, Shi XB, Zou JX, Chen H, Zhang J, Chen X, Luo J, deVere White RW, Kung HJ, Evans CP, Gao AC. PMID: 22479342; PMCID: PMC3316551.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsCells
    30. Translational repression of p53 by RNPC1, a p53 target overexpressed in lymphomas. Genes Dev. 2011 Jul 15; 25(14):1528-43. Zhang J, Cho SJ, Shu L, Yan W, Guerrero T, Kent M, Skorupski K, Chen H, Chen X. PMID: 21764855; PMCID: PMC3143942.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    31. Nuclear receptor coregulators as a new paradigm for therapeutic targeting. Adv Drug Deliv Rev. 2010 Oct 30; 62(13):1227-37. Hsia EY, Goodson ML, Zou JX, Privalsky ML, Chen HW. PMID: 20933027; PMCID: PMC5004779.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    32. ANCCA/ATAD2 overexpression identifies breast cancer patients with poor prognosis, acting to drive proliferation and survival of triple-negative cells through control of B-Myb and EZH2. Cancer Res. 2010 Nov 15; 70(22):9402-12. Kalashnikova EV, Revenko AS, Gemo AT, Andrews NP, Tepper CG, Zou JX, Cardiff RD, Borowsky AD, Chen HW. PMID: 20864510; PMCID: PMC2982862.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    33. Chromatin loading of E2F-MLL complex by cancer-associated coregulator ANCCA via reading a specific histone mark. Mol Cell Biol. 2010 Nov; 30(22):5260-72. Revenko AS, Kalashnikova EV, Gemo AT, Zou JX, Chen HW. PMID: 20855524; PMCID: PMC2976367.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    34. KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9671-6. Hsia DA, Tepper CG, Pochampalli MR, Hsia EY, Izumiya C, Huerta SB, Wright ME, Chen HW, Kung HJ, Izumiya Y. PMID: 20457893; PMCID: PMC2906833.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansCells
    35. Deregulated E2F and the AAA+ coregulator ANCCA drive proto-oncogene ACTR/AIB1 overexpression in breast cancer. Mol Cancer Res. 2010 Feb; 8(2):183-93. Hsia EY, Kalashnikova EV, Revenko AS, Zou JX, Borowsky AD, Chen HW. PMID: 20124470.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    36. The roles and action mechanisms of p160/SRC coactivators and the ANCCA coregulator in cancer. Prog Mol Biol Transl Sci. 2009; 87:261-98. Hsia EY, Zou JX, Chen HW. PMID: 20374707.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    37. The steroid receptor coactivator-1 regulates twist expression and promotes breast cancer metastasis. Cancer Res. 2009 May 01; 69(9):3819-27. Qin L, Liu Z, Chen H, Xu J. PMID: 19383905; PMCID: PMC2911143.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    38. Androgen-induced coactivator ANCCA mediates specific androgen receptor signaling in prostate cancer. Cancer Res. 2009 Apr 15; 69(8):3339-46. Zou JX, Guo L, Revenko AS, Tepper CG, Gemo AT, Kung HJ, Chen HW. PMID: 19318566.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    39. Prolonged androgen receptor loading onto chromatin and the efficient recruitment of p160 coactivators contribute to androgen-independent growth of prostate cancer cells. Prostate. 2008 Dec 01; 68(16):1816-26. Shi XB, Xue L, Zou JX, Gandour-Edwards R, Chen H, deVere White RW. PMID: 18780293.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    40. The AIB1 oncogene promotes breast cancer metastasis by activation of PEA3-mediated matrix metalloproteinase 2 (MMP2) and MMP9 expression. Mol Cell Biol. 2008 Oct; 28(19):5937-50. Qin L, Liao L, Redmond A, Young L, Yuan Y, Chen H, O'Malley BW, Xu J. PMID: 18644862; PMCID: PMC2547002.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansAnimalsCells
    41. Proto-oncogene ACTR/AIB1 promotes cancer cell invasion by up-regulating specific matrix metalloproteinase expression. Cancer Lett. 2008 Mar 08; 261(1):64-73. Li LB, Louie MC, Chen HW, Zou JX. PMID: 18162290.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    42. ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18067-72. Zou JX, Revenko AS, Li LB, Gemo AT, Chen HW. PMID: 17998543; PMCID: PMC2084297.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    43. Inappropriate activation of the androgen receptor by nonsteroids: involvement of the Src kinase pathway and its therapeutic implications. Cancer Res. 2006 Nov 01; 66(21):10449-59. Desai SJ, Ma AH, Tepper CG, Chen HW, Kung HJ. PMID: 17079466.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    44. ACTR/AIB1/SRC-3 and androgen receptor control prostate cancer cell proliferation and tumor growth through direct control of cell cycle genes. Prostate. 2006 Oct 01; 66(14):1474-86. Zou JX, Zhong Z, Shi XB, Tepper CG, deVere White RW, Kung HJ, Chen H. PMID: 16921507.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    45. Male germ cell-associated kinase, a male-specific kinase regulated by androgen, is a coactivator of androgen receptor in prostate cancer cells. Cancer Res. 2006 Sep 01; 66(17):8439-47. Ma AH, Xia L, Desai SJ, Boucher DL, Guan Y, Shih HM, Shi XB, deVere White RW, Chen HW, Tepper CG, Kung HJ. PMID: 16951154.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    46. Direct control of cell cycle gene expression by proto-oncogene product ACTR, and its autoregulation underlies its transforming activity. Mol Cell Biol. 2006 May; 26(10):3810-23. Louie MC, Revenko AS, Zou JX, Yao J, Chen HW. PMID: 16648476; PMCID: PMC1489001.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    47. Genome-wide analysis of chromosomal features repressing human immunodeficiency virus transcription. J Virol. 2005 Jun; 79(11):6610-9. Lewinski MK, Bisgrove D, Shinn P, Chen H, Hoffmann C, Hannenhalli S, Verdin E, Berry CC, Ecker JR, Bushman FD. PMID: 15890899; PMCID: PMC1112149.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansCells
    48. ACTR/AIB1 functions as an E2F1 coactivator to promote breast cancer cell proliferation and antiestrogen resistance. Mol Cell Biol. 2004 Jun; 24(12):5157-71. Louie MC, Zou JX, Rabinovich A, Chen HW. PMID: 15169882; PMCID: PMC419858.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansCells
    49. Interleukin-8 confers androgen-independent growth and migration of LNCaP: differential effects of tyrosine kinases Src and FAK. Oncogene. 2004 Mar 18; 23(12):2197-205. Lee LF, Louie MC, Desai SJ, Yang J, Chen HW, Evans CP, Kung HJ. PMID: 14767470.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    50. Characterization of the chromosomal binding sites and dimerization partners of the viral oncoprotein Meq in Marek's disease virus-transformed T cells. J Virol. 2003 Dec; 77(23):12841-51. Levy AM, Izumiya Y, Brunovskis P, Xia L, Parcells MS, Reddy SM, Lee L, Chen HW, Kung HJ. PMID: 14610205; PMCID: PMC262596.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    51. Androgen-induced recruitment of RNA polymerase II to a nuclear receptor-p160 coactivator complex. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2226-30. Louie MC, Yang HQ, Ma AH, Xu W, Zou JX, Kung HJ, Chen HW. PMID: 12589022; PMCID: PMC151322.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    52. Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. J Biol Chem. 2003 Feb 14; 278(7):5255-63. Xia Y, Pao GM, Chen HW, Verma IM, Hunter T. PMID: 12431996.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansCells
    53. Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators. Nature. 2002 Jan 31; 415(6871):549-53. Demarest SJ, Martinez-Yamout M, Chung J, Chen H, Xu W, Dyson HJ, Evans RM, Wright PE. PMID: 11823864.
      View in: PubMed   Mentions: 178     Fields:    Translation:AnimalsCells
    54. A transcriptional switch mediated by cofactor methylation. Science. 2001 Dec 21; 294(5551):2507-11. Xu W, Chen H, Du K, Asahara H, Tini M, Emerson BM, Montminy M, Evans RM. PMID: 11701890.
      View in: PubMed   Mentions: 152     Fields:    Translation:AnimalsCells
    55. HATs on and beyond chromatin. Curr Opin Cell Biol. 2001 Apr; 13(2):218-24. Chen H, Tini M, Evans RM. PMID: 11248556.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    56. Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. Cell. 1999 Sep 03; 98(5):675-86. Chen H, Lin RJ, Xie W, Wilpitz D, Evans RM. PMID: 10490106.
      View in: PubMed   Mentions: 184     Fields:    Translation:HumansCells
    57. A viral mechanism for inhibition of p300 and PCAF acetyltransferase activity. Cell. 1999 Feb 05; 96(3):393-403. Chakravarti D, Ogryzko V, Kao HY, Nash A, Chen H, Nakatani Y, Evans RM. PMID: 10025405.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansAnimalsCells
    58. The histone acetylase PCAF is a nuclear receptor coactivator. Genes Dev. 1998 Jun 01; 12(11):1638-51. Blanco JC, Minucci S, Lu J, Yang XJ, Walker KK, Chen H, Evans RM, Nakatani Y, Ozato K. PMID: 9620851; PMCID: PMC316869.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    59. BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites. Genes Dev. 1998 May 01; 12(9):1269-77. Blumberg B, Kang H, Bolado J, Chen H, Craig AG, Moreno TA, Umesono K, Perlmann T, De Robertis EM, Evans RM. PMID: 9573044; PMCID: PMC316771.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    60. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. Cell. 1998 Apr 17; 93(2):229-40. Nagy L, Tontonoz P, Alvarez JG, Chen H, Evans RM. PMID: 9568715.
      View in: PubMed   Mentions: 440     Fields:    Translation:HumansAnimalsCells
    61. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell. 1997 Aug 08; 90(3):569-80. Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM. PMID: 9267036.
      View in: PubMed   Mentions: 413     Fields:    Translation:HumansAnimalsCells
    62. Retinoid X and retinoic acid receptors interact with transcription factor II-B by distinct mechanisms. Mol Cell Endocrinol. 1997 Apr 25; 129(1):55-61. Chen HW, Privalsky ML. PMID: 9175629.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    63. Plasticity of tetramer formation by retinoid X receptors. An alternative paradigm for DNA recognition. J Biol Chem. 1997 Apr 11; 272(15):9860-7. Lin BC, Wong CW, Chen HW, Privalsky ML. PMID: 9092522.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    64. Cooperative formation of high-order oligomers by retinoid X receptors: an unexpected mode of DNA recognition. Proc Natl Acad Sci U S A. 1995 Jan 17; 92(2):422-6. Chen H, Privalsky ML. PMID: 7831303; PMCID: PMC42752.
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    65. A physical map of the Myxococcus xanthus chromosome. Proc Natl Acad Sci U S A. 1994 Sep 27; 91(20):9584-7. He Q, Chen H, Kuspa A, Cheng Y, Kaiser D, Shimkets LJ. PMID: 7937810; PMCID: PMC44857.
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    66. The erbA oncogene represses the actions of both retinoid X and retinoid A receptors but does so by distinct mechanisms. Mol Cell Biol. 1993 Oct; 13(10):5970-80. Chen HW, Privalsky ML. PMID: 8105369; PMCID: PMC364641.
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    67. Nuclear hormone receptors involved in neoplasia: erb A exhibits a novel DNA sequence specificity determined by amino acids outside of the zinc-finger domain. Mol Cell Biol. 1993 Apr; 13(4):2366-76. Chen H, Smit-McBride Z, Lewis S, Sharif M, Privalsky ML. PMID: 8096060; PMCID: PMC359557.
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    68. v-erbA acts on retinoic acid receptors in immature avian erythroid cells. J Virol. 1993 Feb; 67(2):1067-74. Sande S, Sharif M, Chen H, Privalsky M. PMID: 8093487; PMCID: PMC237462.
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    69. Physical map of the Myxococcus xanthus chromosome. J Bacteriol. 1991 Mar; 173(6):2109-15. Chen HW, Kuspa A, Keseler IM, Shimkets LJ. PMID: 1848221; PMCID: PMC207747.
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    70. Genome size of Myxococcus xanthus determined by pulsed-field gel electrophoresis. J Bacteriol. 1990 Aug; 172(8):4206-13. Chen H, Keseler IM, Shimkets LJ. PMID: 2165472; PMCID: PMC213243.
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