Yoshihiro Izumiya

Title(s)Associate Professor, Dermatology
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wang HJ, Pochampalli M, Wang LY, Zou JX, Li PS, Hsu SC, Wang BJ, Huang SH, Yang P, Yang JC, Chu CY, Hsieh CL, Sung SY, Li CF, Tepper CG, Ann DK, Gao AC, Evans CP, Izumiya Y, Chuu CP, Wang WC, Chen HW, Kung HJ. KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC. Oncogene. 2019 Jan; 38(1):17-32. PMID: 30072740.
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    2. Chen CP, Chuang F, Izumiya Y. Functional Imaging of Viral Transcription Factories Using 3D Fluorescence Microscopy. J Vis Exp. 2018 01 18; (131). PMID: 29443057.
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    3. Campbell M, Watanabe T, Nakano K, Davis RR, Lyu Y, Tepper CG, Durbin-Johnson B, Fujimuro M, Izumiya Y. KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation. Nat Commun. 2018 01 04; 9(1):49. PMID: 29302027.
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    4. Zhou F, Shimoda M, Olney L, Lyu Y, Tran K, Jiang G, Nakano K, Davis RR, Tepper CG, Maverakis E, Campbell M, Li Y, Dandekar S, Izumiya Y. Oncolytic Reactivation of KSHV as a Therapeutic Approach for Primary Effusion Lymphoma. Mol Cancer Ther. 2017 11; 16(11):2627-2638. PMID: 28847988.
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    5. Lyu Y, Nakano K, Davis RR, Tepper CG, Campbell M, Izumiya Y. ZIC2 is Essential for Maintenance of Latency and is a Target of an Immediate-Early Protein during KSHV Lytic Reactivation. J Virol. 2017 Aug 23. PMID: 28835494.
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    6. Chen CP, Lyu Y, Chuang F, Nakano K, Izumiya C, Jin D, Campbell M, Izumiya Y. Kaposi's Sarcoma-Associated Herpesvirus Hijacks RNA Polymerase II To Create a Viral Transcriptional Factory. J Virol. 2017 06 01; 91(11). PMID: 28331082.
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    7. Wakeman BS, Izumiya Y, Speck SH. Identification of Novel Kaposi's Sarcoma-Associated Herpesvirus Orf50 Transcripts: Discovery of New RTA Isoforms with Variable Transactivation Potential. J Virol. 2017 Jan 01; 91(1). PMID: 27795414.
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    8. Wang LY, Hung CL, Chen YR, Yang JC, Wang J, Campbell M, Izumiya Y, Chen HW, Wang WC, Ann DK, Kung HJ. KDM4A Coactivates E2F1 to Regulate the PDK-Dependent Metabolic Switch between Mitochondrial Oxidation and Glycolysis. Cell Rep. 2016 09 13; 16(11):3016-3027. PMID: 27626669; PMCID: PMC5024724.
    9. Bhatt AP, Wong JP, Weinberg MS, Host KM, Giffin LC, Buijnink J, van Dijk E, Izumiya Y, Kung HJ, Temple BR, Damania B. A viral kinase mimics S6 kinase to enhance cell proliferation. Proc Natl Acad Sci U S A. 2016 07 12; 113(28):7876-81. PMID: 27342859.
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    10. Nakajima K, Zhu K, Sun YH, Hegyi B, Zeng Q, Murphy CJ, Small JV, Chen-Izu Y, Izumiya Y, Penninger JM, Zhao M. KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis. Nat Commun. 2015 Oct 09; 6:8532. PMID: 26449415; PMCID: PMC4603535.
    11. Schreiber CA, Sakuma T, Izumiya Y, Holditch SJ, Hickey RD, Bressin RK, Basu U, Koide K, Asokan A, Ikeda Y. An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses. PLoS Pathog. 2015 Aug; 11(8):e1005082. PMID: 26244496; PMCID: PMC4526370.
    12. Campbell M, Kung HJ, Izumiya Y. Long non-coding RNA and epigenetic gene regulation of KSHV. Viruses. 2014 Nov 04; 6(11):4165-77. PMID: 25375882; PMCID: PMC4246214.
    13. Kim KY, Wang DH, Campbell M, Huerta SB, Shevchenko B, Izumiya C, Izumiya Y. PRMT4-mediated arginine methylation negatively regulates retinoblastoma tumor suppressor protein and promotes E2F-1 dissociation. Mol Cell Biol. 2015 Jan; 35(1):238-48. PMID: 25348716; PMCID: PMC4295381.
    14. Fujita M, Takada YK, Izumiya Y, Takada Y. The binding of monomeric C-reactive protein (mCRP) to Integrins avß3 and a4ß1 is related to its pro-inflammatory action. PLoS One. 2014; 9(4):e93738. PMID: 24695572; PMCID: PMC3973595.
    15. Toth Z, Brulois K, Lee HR, Izumiya Y, Tepper C, Kung HJ, Jung JU. Biphasic euchromatin-to-heterochromatin transition on the KSHV genome following de novo infection. PLoS Pathog. 2013; 9(12):e1003813. PMID: 24367262; PMCID: PMC3868514.
    16. Wang HJ, Hsieh YJ, Cheng WC, Lin CP, Lin YS, Yang SF, Chen CC, Izumiya Y, Yu JS, Kung HJ, Wang WC. JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1a-mediated glucose metabolism. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):279-84. PMID: 24344305; PMCID: PMC3890888.
    17. Campbell M, Kim KY, Chang PC, Huerta S, Shevchenko B, Wang DH, Izumiya C, Kung HJ, Izumiya Y. A lytic viral long noncoding RNA modulates the function of a latent protein. J Virol. 2014 Feb; 88(3):1843-8. PMID: 24257619; PMCID: PMC3911622.
    18. Izumiya Y, Kobayashi K, Kim KY, Pochampalli M, Izumiya C, Shevchenko B, Wang DH, Huerta SB, Martinez A, Campbell M, Kung HJ. Kaposi's sarcoma-associated herpesvirus K-Rta exhibits SUMO-targeting ubiquitin ligase (STUbL) like activity and is essential for viral reactivation. PLoS Pathog. 2013; 9(8):e1003506. PMID: 23990779; PMCID: PMC3749962.
    19. Kim KY, Huerta SB, Izumiya C, Wang DH, Martinez A, Shevchenko B, Kung HJ, Campbell M, Izumiya Y. Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen regulates the KSHV epigenome by association with the histone demethylase KDM3A. J Virol. 2013 Jun; 87(12):6782-93. PMID: 23576503; PMCID: PMC3676133.
    20. Campbell M, Izumiya Y. Post-Translational Modifications of Kaposi's Sarcoma-Associated Herpesvirus Regulatory Proteins - SUMO and KSHV. Front Microbiol. 2012; 3:31. PMID: 22347876; PMCID: PMC3278983.
    21. Campbell M, Chang PC, Huerta S, Izumiya C, Davis R, Tepper CG, Kim KY, Shevchenko B, Wang DH, Jung JU, Luciw PA, Kung HJ, Izumiya Y. Protein arginine methyltransferase 1-directed methylation of Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen. J Biol Chem. 2012 Feb 17; 287(8):5806-18. PMID: 22179613; PMCID: PMC3285351.
    22. Chang PC, Fitzgerald LD, Hsia DA, Izumiya Y, Wu CY, Hsieh WP, Lin SF, Campbell M, Lam KS, Luciw PA, Tepper CG, Kung HJ. Histone demethylase JMJD2A regulates Kaposi's sarcoma-associated herpesvirus replication and is targeted by a viral transcriptional factor. J Virol. 2011 Apr; 85(7):3283-93. PMID: 21228229; PMCID: PMC3067885.
    23. Hsia DA, Tepper CG, Pochampalli MR, Hsia EY, Izumiya C, Huerta SB, Wright ME, Chen HW, Kung HJ, Izumiya Y. KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9671-6. PMID: 20457893; PMCID: PMC2906833.
    24. Suchodolski PF, Izumiya Y, Lupiani B, Ajithdoss DK, Lee LF, Kung HJ, Reddy SM. Both homo and heterodimers of Marek's disease virus encoded Meq protein contribute to transformation of lymphocytes in chickens. Virology. 2010 Apr 10; 399(2):312-21. PMID: 20137800.
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    25. Chang PC, Izumiya Y, Wu CY, Fitzgerald LD, Campbell M, Ellison TJ, Lam KS, Luciw PA, Kung HJ. Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a SUMO E3 ligase that is SIM-dependent and SUMO-2/3-specific. J Biol Chem. 2010 Feb 19; 285(8):5266-73. PMID: 20034935; PMCID: PMC2820755.
    26. Chang PC, Fitzgerald LD, Van Geelen A, Izumiya Y, Ellison TJ, Wang DH, Ann DK, Luciw PA, Kung HJ. Kruppel-associated box domain-associated protein-1 as a latency regulator for Kaposi's sarcoma-associated herpesvirus and its modulation by the viral protein kinase. Cancer Res. 2009 Jul 15; 69(14):5681-9. PMID: 19584288; PMCID: PMC2731626.
    27. Ellison TJ, Izumiya Y, Izumiya C, Luciw PA, Kung HJ. A comprehensive analysis of recruitment and transactivation potential of K-Rta and K-bZIP during reactivation of Kaposi's sarcoma-associated herpesvirus. Virology. 2009 Apr 25; 387(1):76-88. PMID: 19269659; PMCID: PMC4327937.
    28. Izumiya Y, Izumiya C, Hsia D, Ellison TJ, Luciw PA, Kung HJ. NF-kappaB serves as a cellular sensor of Kaposi's sarcoma-associated herpesvirus latency and negatively regulates K-Rta by antagonizing the RBP-Jkappa coactivator. J Virol. 2009 May; 83(9):4435-46. PMID: 19244329; PMCID: PMC2668470.
    29. Suchodolski PF, Izumiya Y, Lupiani B, Ajithdoss DK, Gilad O, Lee LF, Kung HJ, Reddy SM. Homodimerization of Marek's disease virus-encoded Meq protein is not sufficient for transformation of lymphocytes in chickens. J Virol. 2009 Jan; 83(2):859-69. PMID: 18971275; PMCID: PMC2612399.
    30. Gautschi O, Tepper CG, Purnell PR, Izumiya Y, Evans CP, Green TP, Desprez PY, Lara PN, Gandara DR, Mack PC, Kung HJ. Regulation of Id1 expression by SRC: implications for targeting of the bone morphogenetic protein pathway in cancer. Cancer Res. 2008 Apr 01; 68(7):2250-8. PMID: 18381431.
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    31. Izumiya Y, Izumiya C, Van Geelen A, Wang DH, Lam KS, Luciw PA, Kung HJ. Kaposi's sarcoma-associated herpesvirus-encoded protein kinase and its interaction with K-bZIP. J Virol. 2007 Feb; 81(3):1072-82. PMID: 17108053; PMCID: PMC1797516.
    32. Levy AM, Gilad O, Xia L, Izumiya Y, Choi J, Tsalenko A, Yakhini Z, Witter R, Lee L, Cardona CJ, Kung HJ. Marek's disease virus Meq transforms chicken cells via the v-Jun transcriptional cascade: a converging transforming pathway for avian oncoviruses. Proc Natl Acad Sci U S A. 2005 Oct 11; 102(41):14831-6. PMID: 16203997; PMCID: PMC1253582.
    33. Izumiya Y, Ellison TJ, Yeh ET, Jung JU, Luciw PA, Kung HJ. Kaposi's sarcoma-associated herpesvirus K-bZIP represses gene transcription via SUMO modification. J Virol. 2005 Aug; 79(15):9912-25. PMID: 16014952; PMCID: PMC1181544.
    34. Hamza MS, Reyes RA, Izumiya Y, Wisdom R, Kung HJ, Luciw PA. ORF36 protein kinase of Kaposi's sarcoma herpesvirus activates the c-Jun N-terminal kinase signaling pathway. J Biol Chem. 2004 Sep 10; 279(37):38325-30. PMID: 15247271.
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    35. Levy AM, Izumiya Y, Brunovskis P, Xia L, Parcells MS, Reddy SM, Lee L, Chen HW, Kung HJ. Characterization of the chromosomal binding sites and dimerization partners of the viral oncoprotein Meq in Marek's disease virus-transformed T cells. J Virol. 2003 Dec; 77(23):12841-51. PMID: 14610205; PMCID: PMC262596.
    36. Izumiya Y, Lin SF, Ellison TJ, Levy AM, Mayeur GL, Izumiya C, Kung HJ. Cell cycle regulation by Kaposi's sarcoma-associated herpesvirus K-bZIP: direct interaction with cyclin-CDK2 and induction of G1 growth arrest. J Virol. 2003 Sep; 77(17):9652-61. PMID: 12915577; PMCID: PMC187423.
    37. Izumiya Y, Lin SF, Ellison T, Chen LY, Izumiya C, Luciw P, Kung HJ. Kaposi's sarcoma-associated herpesvirus K-bZIP is a coregulator of K-Rta: physical association and promoter-dependent transcriptional repression. J Virol. 2003 Jan; 77(2):1441-51. PMID: 12502859; PMCID: PMC140808.
    38. Kato K, Izumiya Y, Tohya Y, Takahashi E, Hirai K, Kawaguchi Y. Identification and characterization of Marek's disease virus serotype 1 (MDV1) ICP22 gene product: MDV1 ICP22 transactivates the MDV1 ICP27 promoter synergistically with MDV1 ICP4. Vet Microbiol. 2002 Apr 02; 85(4):305-13. PMID: 11856580.
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