Amanda Kirane

Title(s)Assistant Professor, Surgery
SchoolUniversity of California, Davis
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    1. Rewiring STAT signaling from the cell surface with Trikine immunotherapeutics. Science. 2026 Feb 19; eadx9954. Rodriguez GE, Zhao Y, Nishiga Y, Peprah F, Shen J, Abhiraman GC, Ogishi M, Zhang C, Saco J, Waghray D, Serasanambati M, Torres L, Simone BW, Su L, Wilson SC, Yang A, Sun Q, Picton L, Saxton RA, Bhandarkar V, Lee MJ, Andrews E, Jiang H, Obenaus M, Yen M, Atajanova T, Blish CA, Spranger S, Wherry EJ, Kirane A, Ribas A, Raulet DH, Kalbasi A, Dougan SK, Dougan M, Sage J, Garcia KC. PMID: 41712697; PMCID: PMC12963926.
      View in: PubMed   Mentions:
    2. Disruption of fibroblast MYD88 signaling promotes antitumor immunity in pancreatic ductal adenocarcinoma. Cell Rep. 2025 Oct 28; 44(10):116347. Korah M, Reveron-Thornton RF, Fallah M, Xie PY, Gonçalves A, Guo C, Agolia JP, Delitto AE, Flojo RAB, Reddy B, Yip KA, Lu JM, Tomasso A, Tabora AD, Guo JL, Bauer-Rowe KE, Pham B, Goyal L, Kirane AR, Charville GW, Chaudhuri O, Dua MM, Visser BC, Lee B, Poultsides GA, Wan DC, Norton JA, Foster DS, Longaker MT, Delitto D. PMID: 41004339.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Antibody-Free Immunopeptide Nanoconjugates for Brain-Targeted Drug Delivery in Glioblastoma Multiforme. Bioconjug Chem. 2025 Oct 15; 36(10):2132-2144. Sharma S, Lee D, Maity S, Singh P, Chadokiya J, Mohaghegh N, Hassani A, Kim H, Gangarade A, Ljubimova JY, Kirane A, Holler E. PMID: 40601862.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Antibody-Free Immunopeptide Nano-Conjugates for Brain-Targeted Drug Delivery in Glioblastoma Multiforme. bioRxiv. 2025 Mar 12. Sharma S, Lee D, Maity S, Singh P, Chadokiya J, Mohaghegh N, Hassani A, Kim H, Gangarade A, Ljubimova JY, Kirane A, Holler E. PMID: 40161747; PMCID: PMC11952356.
      View in: PubMed   Mentions:
    5. Surgical Considerations in Tumor-Infiltrating Lymphocyte Therapy: Challenges and Opportunities. Transplant Cell Ther. 2025 Mar; 31(3S):S591-S598. Kirane A, Lee D, Ariyan C. PMID: 40089328.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    6. Predictive Biomarkers for Immune Checkpoint Inhibitor Therapy in Advanced Melanomas. Surg Oncol Clin N Am. 2025 Jul; 34(3):437-451. Wagner E, Larijani B, Kirane AR. PMID: 40413009.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. SPP1hi macrophages, NKG7 T cells, CCL5hi fibroblasts, and IgM plasma cells are dominant features of necrobiosis. JCI Insight. 2025 Feb 24; 10(4). Le ST, Marusina AI, Merleev AA, Kirane A, Kruglinskaya O, Kunitsyn A, Kuzminykh NY, Xing X, Li SY, Liakos W, Kahlenberg JM, Gompers A, Downing L, Marella S, Billi AC, Harms PW, Tsoi LC, Brüggen MC, Adamopoulos IE, Gudjonsson JE, Maverakis E. PMID: 39989459; PMCID: PMC11949047.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. Advancing precision cancer immunotherapy drug development, administration, and response prediction with AI-enabled Raman spectroscopy. Front Immunol. 2024; 15:1520860. Chadokiya J, Chang K, Sharma S, Hu J, Lill JR, Dionne J, Kirane A. PMID: 39850874; PMCID: PMC11753970.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    9. Biochemical, Radiographic, or Pathologic Response to Neoadjuvant Chemotherapy in Resected Pancreatic Cancer: Which is Best? Ann Surg. 2024 Dec 16. Ahmad MU, Javadi CS, Chang JD, Forgó E, Delitto DJ, Dua MM, Fisher GA, Heestand GM, Chang DT, Pollom E, Vitzthum LK, Kirane A, Lee B, Visser BC, Norton JA, Poultsides GA. PMID: 39676639.
      View in: PubMed   Mentions: 1     Fields:    
    10. Are Palliative Interventions Worth the Risk in Advanced Gastric Cancer? A Systematic Review. J Clin Med. 2024 Sep 28; 13(19). Gingrich AA, Flojo RB, Walsh A, Olson J, Hanson D, Bateni SB, Gholami S, Kirane AR. PMID: 39407868; PMCID: PMC11478195.
      View in: PubMed   Mentions: 1  
    11. From Genotype to Phenotype: Raman Spectroscopy and Machine Learning for Label-Free Single-Cell Analysis. ACS Nano. 2024 07 16; 18(28):18101-18117. Zhang Y, Chang K, Ogunlade B, Herndon L, Tadesse LF, Kirane AR, Dionne JA. PMID: 38950145.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    12. Review of Role of Surgery with Electroporation in Melanoma: Chemotherapy, Immunotherapy, and Gene Delivery. J Clin Med. 2024 Jun 29; 13(13). Ahmad MU, Walsh A, Kirane A. PMID: 38999394; PMCID: PMC11242408.
      View in: PubMed   Mentions: 2  
    13. Natural history of undifferentiated pleomorphic sarcoma: Experience from the US Sarcoma Collaborative. J Surg Oncol. 2024 Jun; 129(7):1354-1363. Makris EA, Tran TB, Delitto DJ, Lee B, Ethun CG, Grignol V, Harrison Howard J, Bedi M, Clark Gamblin T, Tseng J, Roggin KK, Chouliaras K, Votanopoulos K, Cullinan D, Fields RC, Cardona K, Poultsides G, Kirane A. PMID: 38562002.
      View in: PubMed   Mentions: 4     Fields:    
    14. Multiregional Sequencing Analysis Reveals Extensive Genetic Heterogeneity in Gastric Tumors from Latinos. Cancer Res Commun. 2022 11; 2(11):1487-1496. Toal TW, Estrada-Florez AP, Polanco-Echeverry GM, Sahasrabudhe RM, Lott PC, Suarez-Olaya JJ, Guevara-Tique AA, Rocha S, Morales-Arana A, Castro-Valencia F, Urayama S, Kirane A, Wei D, Rios-Sarabia N, Medrano R, Mantilla A, Echeverry de Polanco M, Torres J, Bohorquez-Lozano ME, Carvajal-Carmona LG. PMID: 36970058; PMCID: PMC10035402.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    15. Intralesional interleukin-2 augmentation therapy in treatment-refractory melanoma. Dermatol Ther. 2022 11; 35(11):e15853. Le ST, Ji-Xu A, Liakos W, Toussi AM, Cheng MY, Ma C, Wang EA, Wilken R, Boddu S, Downing L, Kao J, Davis JR, Monjazeb AM, Fung MA, Konia TH, Maverakis E, Kirane AR. PMID: 36151592.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. Proprotein convertase subtilisin/kexin type 9 is a psoriasis-susceptibility locus that is negatively related to IL36G. JCI Insight. 2022 08 22; 7(16). Merleev A, Ji-Xu A, Toussi A, Tsoi LC, Le ST, Luxardi G, Xing X, Wasikowski R, Liakos W, Brüggen MC, Elder JT, Adamopoulos IE, Izumiya Y, Leal AR, Li Q, Kuzminykh NY, Kirane A, Marusina AI, Gudjonsson JE, Maverakis E. PMID: 35862195; PMCID: PMC9462487.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    17. Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes. JCI Insight. 2022 08 22; 7(16). Merleev AA, Le ST, Alexanian C, Toussi A, Xie Y, Marusina AI, Watkins SM, Patel F, Billi AC, Wiedemann J, Izumiya Y, Kumar A, Uppala R, Kahlenberg JM, Liu FT, Adamopoulos IE, Wang EA, Ma C, Cheng MY, Xiong H, Kirane A, Luxardi G, Andersen B, Tsoi LC, Lebrilla CB, Gudjonsson JE, Maverakis E. PMID: 35900871; PMCID: PMC9462509.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    18. Chemotherapy After Diagnosis of Malignant Bowel Obstruction is Associated with Superior Survival for Medicare Patients with Advanced Malignancy. Ann Surg Oncol. 2021 Nov; 28(12):7555-7563. Bateni SB, Gingrich AA, Kirane AR, Sauder CAM, Gholami S, Bold RJ, Meyers FJ, Canter RJ. PMID: 33829359; PMCID: PMC8519893.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    19. Advances in Modeling the Immune Microenvironment of Colorectal Cancer. Front Immunol. 2020; 11:614300. Yoon PS, Del Piccolo N, Shirure VS, Peng Y, Kirane A, Canter RJ, Fields RC, George SC, Gholami S. PMID: 33643296; PMCID: PMC7902698.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    20. Novel Targets in Melanoma: Intralesional and Combination Therapy to Manipulate the Immune Response. Surg Oncol Clin N Am. 2020 Jul; 29(3):467-483. Gingrich AA, Kirane AR. PMID: 32482321.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    21. Elderly Age Is Associated With More Conservative Treatment of Invasive Melanoma. Anticancer Res. 2020 May; 40(5):2895-2903. Bateni SB, Johns AJ, Gingrich AA, Gholami S, Bold RJ, Canter RJ, Kirane AR. PMID: 32366440.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    22. The Role of Palliative Surgery for Malignant Bowel Obstruction and Perforation in Advanced Microsatellite Instability-High Colorectal Carcinoma in the Era of Immunotherapy: Case Report. Front Oncol. 2020; 10:581. Judge SJ, Ji J, Liu J, Kaur M, Kim E, Gong J, Tam KW, Kirane AR, Gholami S, Canter RJ, Bold RJ, Gangi A, Fakih M, Cho M. PMID: 32373540; PMCID: PMC7186327.
      View in: PubMed   Mentions: 1  
    23. Association of MRI T2 Signal Intensity With Desmoid Tumor Progression During Active Observation: A Retrospective Cohort Study. Ann Surg. 2020 04; 271(4):748-755. Cassidy MR, Lefkowitz RA, Long N, Qin LX, Kirane A, Sbaity E, Hameed M, Coit DG, Brennan MF, Singer S, Crago AM. PMID: 30418203; PMCID: PMC6736761.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    24. Non-surgical management of primary invasive melanoma. J Dermatolog Treat. 2021 Sep; 32(6):631-634. Wang EA, Kao J, Ma C, Cheng MY, Barton VR, Petukhova TA, Kiuru M, Maverakis E, Kirane AR. PMID: 31747810; PMCID: PMC10186989.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Morbidity, mortality and temporal trends in the surgical management of retroperitoneal sarcoma: An ACS-NSQIP follow up analysis. J Surg Oncol. 2019 Sep; 120(4):753-760. Judge SJ, Lata-Arias K, Yanagisawa M, Darrow MA, Monjazeb AM, Kirane AR, Bold RJ, Canter RJ, Canter DJ. PMID: 31355444.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    26. Role of Radiation Therapy in Adult Extraskeletal Ewing's Sarcoma Patients Treated with Chemotherapy and Surgery. Sarcoma. 2019; 2019:5413527. Saiz AM, Gingrich AA, Canter RJ, Kirane AR, Monjazeb AM, Randall RL, Thorpe SW. PMID: 31178655; PMCID: PMC6507246.
      View in: PubMed   Mentions: 3  
    27. Extremity soft tissue sarcoma in the elderly: Are we overtreating or undertreating this potentially vulnerable patient population? J Surg Oncol. 2019 Jun; 119(8):1087-1098. Gingrich AA, Bateni SB, Monjazeb AM, Thorpe SW, Kirane AR, Bold RJ, Canter RJ. PMID: 30977916.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    28. Clinical Outcomes and Costs Following Unplanned Excisions of Soft Tissue Sarcomas in the Elderly. J Surg Res. 2019 07; 239:125-135. Bateni SB, Gingrich AA, Jeon SY, Hoch JS, Thorpe SW, Kirane AR, Bold RJ, Canter RJ. PMID: 30825757; PMCID: PMC6488355.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    29. Cyclooxygenase-2 Inhibition Potentiates the Efficacy of Vascular Endothelial Growth Factor Blockade and Promotes an Immune Stimulatory Microenvironment in Preclinical Models of Pancreatic Cancer. Mol Cancer Res. 2019 02; 17(2):348-355. Zhang Y, Kirane A, Huang H, Sorrelle NB, Burrows FJ, Dellinger MT, Brekken RA. PMID: 30333153; PMCID: PMC6359969.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    30. Tumor Symbiosis: Gastrointestinal Stromal Tumor as a Host for Primary Peritoneal Mesothelioma. J Gastrointest Surg. 2019 04; 23(4):879-881. de la Torre J, Banerjee S, Baumgartner J, Lin GY, Burgoyne AM, Kirane A, Sicklick J. PMID: 30132292; PMCID: PMC6384158.
      View in: PubMed   Mentions: 4     Fields:    
    31. Serum C-reactive Protein and Neutrophil/Lymphocyte Ratio After Neoadjuvant Radiotherapy in Soft Tissue Sarcoma. Anticancer Res. 2018 03; 38(3):1491-1497. Yanagisawa M, Gingrich AA, Judge S, Li CS, Wang N, Thorpe SW, Kirane AR, Bold RJ, Monjazeb AM, Canter RJ. PMID: 29491077; PMCID: PMC5836802.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    32. T Cells Dominate the Local Immune Response Induced by Intralesional IL-2 in Combination with Imiquimod and Retinoid for In-Transit Metastatic Melanoma. J Invest Dermatol. 2018 06; 138(6):1442-1445. Ogawa H, Luxardi G, Kirane A, Kulkarni R, Monjazeb AM, Cheng MY, Ma C, Maverakis E. PMID: 29291382.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    33. Size and Location are the Most Important Risk Factors for Malignant Behavior in Resected Solitary Fibrous Tumors. Ann Surg Oncol. 2017 Dec; 24(13):3865-3871. Gholami S, Cassidy MR, Kirane A, Kuk D, Zanchelli B, Antonescu CR, Singer S, Brennan M. PMID: 29039030.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCTClinical Trials
    34. Neoadjuvant Radiotherapy is Associated with R0 Resection and Improved Survival for Patients with Extremity Soft Tissue Sarcoma Undergoing Surgery: A National Cancer Database Analysis. Ann Surg Oncol. 2017 Oct; 24(11):3252-3263. Gingrich AA, Bateni SB, Monjazeb AM, Darrow MA, Thorpe SW, Kirane AR, Bold RJ, Canter RJ. PMID: 28741123; PMCID: PMC5693726.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    35. The modified frailty index to predict morbidity and mortality for retroperitoneal sarcoma resections. J Surg Res. 2017 09; 217:191-197. Park JS, Bateni SB, Bold RJ, Kirane AR, Canter DJ, Canter RJ. PMID: 28587892; PMCID: PMC5603411.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    36. The importance of surgical margins in retroperitoneal sarcoma. J Surg Oncol. 2016 Mar; 113(3):270-6. Kirane A, Crago AM. PMID: 26707028.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    37. Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis. Cancer Res. 2015 Sep 15; 75(18):3699-705. Kirane A, Ludwig KF, Sorrelle N, Haaland G, Sandal T, Ranaweera R, Toombs JE, Wang M, Dineen SP, Micklem D, Dellinger MT, Lorens JB, Brekken RA. PMID: 26206560; PMCID: PMC4572915.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    38. Apricoxib, a novel inhibitor of COX-2, markedly improves standard therapy response in molecularly defined models of pancreatic cancer. Clin Cancer Res. 2012 Sep 15; 18(18):5031-42. Kirane A, Toombs JE, Ostapoff K, Carbon JG, Zaknoen S, Braunfeld J, Schwarz RE, Burrows FJ, Brekken RA. PMID: 22829202; PMCID: PMC3777527.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    39. Epithelial-mesenchymal transition increases tumor sensitivity to COX-2 inhibition by apricoxib. Carcinogenesis. 2012 Sep; 33(9):1639-46. Kirane A, Toombs JE, Larsen JE, Ostapoff KT, Meshaw KR, Zaknoen S, Brekken RA, Burrows FJ. PMID: 22678114; PMCID: PMC3514897.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    40. Intraduodenal sarcoma recurrence of retroperitoneal origin: an unusual cause for a duodenal obstruction. World J Surg Oncol. 2012 Apr 20; 10:59. Bao JJ, Mansour JC, Timmerman RD, Kirane A, Ewing GE, Schwarz RE. PMID: 22520024; PMCID: PMC3478974.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    41. Smac mimetic-derived augmentation of chemotherapeutic response in experimental pancreatic cancer. BMC Cancer. 2011 Jan 12; 11:15. Awasthi N, Kirane A, Schwarz MA, Toombs JE, Brekken RA, Schwarz RE. PMID: 21226944; PMCID: PMC3034706.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
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