Sean James O'Day Judge

Title(s)Assistant Professor in Residence, Med: Surgery
SchoolSchool of Medicine
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    1. Single cell atlas of canine natural killer cells identifies distinct circulating and tissue resident gene profiles. Front Immunol. 2025; 16:1571085. Razmara AM, Lammers M, Judge SJ, Murphy WJ, Gaskill CE, Culp WTN, Gingrich AA, Morris ZS, Rebhun RB, Brown CT, Vail DM, Kent MS, Canter RJ. PMID: 40443661; PMCID: PMC12119461.
      View in: PubMed   Mentions:
    2. What's in a name? Memory NK cells for cancer immunotherapy. J Immunother Cancer. 2025 Jan 31; 13(1). Judge SJ, Purl MC, Murphy WJ, Canter RJ. PMID: 39890423; PMCID: PMC11792271.
      View in: PubMed   Mentions:    Fields:    
    3. Watch and wait in rectal cancer patients with residual mucin on magnetic resonance imaging following neoadjuvant therapy. J Natl Cancer Inst. 2024 Nov 01; 116(11):1761-1766. Judge SJ, Malekzadeh P, Corines MJ, Gollub MJ, Horvat N, Gonen M, Saltz L, Cercek A, Romesser P, Crane C, Shia J, Wei I, Widmar M, Pappou E, Nash GM, Smith JJ, Paty PB, Garcia-Aguilar J, Weiser MR. PMID: 38937278; PMCID: PMC11542991.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    4. Visceral fat area and subcutaneous fat area as measures of body composition in soft tissue sarcoma. J Surg Oncol. 2024 Sep; 130(3):543-551. Garibay ER, Cruz SM, Judge SJ, Monjazeb AM, Thorpe SW, Murphy WJ, Lyu J, Chen S, Bateni CP, Canter RJ. PMID: 39402905; PMCID: PMC11753180.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Consideration of a Novel Surgical Approach in the Management of Gastric Adenocarcinoma and Proximal Polyposis Syndrome. JCO Precis Oncol. 2024 Jun; 8:e2400175. Judge SJ, Gearty SV, Catchings A, Ranganathan M, Roehrl MH, Vardhana SA, Tang L, Stadler ZK, Strong VE. PMID: 38976808; PMCID: PMC11232921.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Preclinical evaluation and first-in-dog clinical trials of PBMC-expanded natural killer cells for adoptive immunotherapy in dogs with cancer. J Immunother Cancer. 2024 Apr 16; 12(4). Razmara AM, Farley LE, Harris RM, Judge SJ, Lammers M, Iranpur KR, Johnson EG, Dunai C, Murphy WJ, Brown CT, Rebhun RB, Kent MS, Canter RJ. PMID: 38631708; PMCID: PMC11029326.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    7. Low-Dose Sorafenib Promotes Cancer Stem Cell Expansion and Accelerated Tumor Progression in Soft Tissue Sarcomas. Int J Mol Sci. 2024 Mar 15; 25(6). Cruz SM, Iranpur KR, Judge SJ, Ames E, Sturgill IR, Farley LE, Darrow MA, Crowley JS, Monjazeb AM, Murphy WJ, Canter RJ. PMID: 38542325; PMCID: PMC10969893.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. Suppressive effects of obesity on NK cells: is it time to incorporate obesity as a clinical variable for NK cell-based cancer immunotherapy regimens? J Immunother Cancer. 2024 Mar 13; 12(3). Canter RJ, Judge SJ, Collins CP, Yoon DJ, Murphy WJ. PMID: 38485185; PMCID: PMC10941146.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    9. Effect of ALDH1A1 and CD44 on Survival and Disease Recurrence in Patients With Osteosarcoma. Cureus. 2024 Jan; 16(1):e52404. Haffner MR, Saiz AM, Darrow MA, Judge SJ, Laun T, Arora A, Taylor SL, Randall RL, Alvarez EM, Thorpe SW. PMID: 38371078; PMCID: PMC10869251.
      View in: PubMed   Mentions:
    10. Characterization of natural killer and cytotoxic T-cell immune infiltrates in pancreatic ductal adenocarcinoma. J Surg Oncol. 2024 Apr; 129(5):885-892. Persky J, Cruz SM, Darrow MA, Judge SJ, Li Y, Bold RJ, Karnezis AN, Matsukuma KE, Qi L, Canter RJ. PMID: 38196111; PMCID: PMC10980567.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    11. Regulation of human and mouse bystander T cell activation responses by PD-1. JCI Insight. 2023 09 22; 8(18). Le CT, Vick LV, Collins C, Dunai C, Sheng MK, Khuat LT, Barao I, Judge SJ, Aguilar EG, Curti B, Dave M, Longo DL, Blazar BR, Canter RJ, Monjazeb AM, Murphy WJ. PMID: 37737264; PMCID: PMC10561715.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    12. Current Practices in Hepatic Artery Infusion (HAI) Chemotherapy: An International Survey of the HAI Consortium Research Network. Ann Surg Oncol. 2023 Nov; 30(12):7362-7370. Judge SJ, Ghalambor T, Cavnar MJ, Lidsky ME, Merkow RP, Cho M, Dominguez-Rosado I, Karanicolas PJ, Mayo SC, Rocha FG, Fields RC, Patel RA, Kennecke HF, Koerkamp BG, Yopp AC, Petrowsky H, Mahalingam D, Kemeny N, D'Angelica M, Gholami S. PMID: 37702903; PMCID: PMC11108096.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    13. Intratumoral NKp46+ natural killer cells are spatially distanced from T and MHC-I+ cells with prognostic implications in soft tissue sarcoma. Front Immunol. 2023; 14:1230534. Cruz SM, Sholevar CJ, Judge SJ, Darrow MA, Iranpur KR, Farley LE, Lammers M, Razmara AM, Dunai C, Gingrich AA, Persky J, Mori H, Thorpe SW, Monjazeb AM, Murphy WJ, Canter RJ. PMID: 37545516; PMCID: PMC10401426.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    14. Sarcopenia and frailty as predictors of surgical morbidity and oncologic outcomes in retroperitoneal sarcoma. J Surg Oncol. 2023 Apr; 127(5):855-861. Nasirishargh A, Grova M, Bateni CP, Judge SJ, Nuno MA, Basmaci UN, Canter RJ, Bateni SB. PMID: 36621854.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    15. Human soft tissue sarcomas harbor an intratumoral viral microbiome which is linked with natural killer cell infiltrate and prognosis. J Immunother Cancer. 2023 01; 11(1). Perry LM, Cruz SM, Kleber KT, Judge SJ, Darrow MA, Jones LB, Basmaci UN, Joshi N, Settles ML, Durbin-Johnson BP, Gingrich AA, Monjazeb AM, Carr-Ascher J, Thorpe SW, Murphy WJ, Eisen JA, Canter RJ. PMID: 36599469; PMCID: PMC9815021.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    16. Genomic Predictors of Recurrence Patterns After Complete Resection of Colorectal Liver Metastases and Adjuvant Hepatic Artery Infusion Chemotherapy by Narayan et al. Ann Surg Oncol. 2022 11; 29(12):7246-7247. Judge SJ, Cho M, Gholami S. PMID: 35829800.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Transcriptome Analysis of Tumor-Infiltrating Lymphocytes Identifies NK Cell Gene Signatures Associated With Lymphocyte Infiltration and Survival in Soft Tissue Sarcomas. Front Immunol. 2022; 13:893177. Judge SJ, Bloomstein JD, Sholevar CJ, Darrow MA, Stoffel KM, Vick LV, Dunai C, Cruz SM, Razmara AM, Monjazeb AM, Rebhun RB, Murphy WJ, Canter RJ. PMID: 35874727; PMCID: PMC9300876.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    18. Inhaled recombinant human IL-15 in dogs with naturally occurring pulmonary metastases from osteosarcoma or melanoma: a phase 1 study of clinical activity and correlates of response. J Immunother Cancer. 2022 06; 10(6). Rebhun RB, York D, Cruz SM, Judge SJ, Razmara AM, Farley LE, Brady RV, Johnson EG, Burton JH, Willcox J, Wittenburg LA, Woolard K, Dunai C, Stewart SL, Sparger EE, Withers SS, Gingrich AA, Skorupski KA, Al-Nadaf S, LeJeune AT, Culp WT, Murphy WJ, Kent MS, Canter RJ. PMID: 35680383; PMCID: PMC9174838.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    19. Natural Killer and T Cell Infiltration in Canine Osteosarcoma: Clinical Implications and Translational Relevance. Front Vet Sci. 2021; 8:771737. Razmara AM, Judge SJ, Gingrich AA, Cruz SM, Culp WTN, Kent MS, Rebhun RB, Canter RJ. PMID: 34869744; PMCID: PMC8635198.
      View in: PubMed   Mentions: 4  
    20. Activation status dictates the function of unlicensed natural killer cells in mice and humans. Blood Adv. 2021 10 26; 5(20):4219-4232. Aguilar EG, Dunai C, Judge SJ, Zamora AE, Khuat LT, Vick LV, Collins CP, Stoffel KM, Alvarez M, Barao I, Miller JS, Blazar BR, Chevallier P, Retiere C, Canter RJ, Murphy WJ. PMID: 34496010; PMCID: PMC8945636.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    21. Comparative Immunogenomics of Canine Natural Killer Cells as Immunotherapy Target. Front Immunol. 2021; 12:670309. Gingrich AA, Reiter TE, Judge SJ, York D, Yanagisawa M, Razmara A, Sturgill I, Basmaci UN, Brady RV, Stoffel K, Murphy WJ, Rebhun RB, Brown CT, Canter RJ. PMID: 34594320; PMCID: PMC8476892.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    22. Surgical and oncologic outcomes following arterial resection and reconstruction for advanced solid tumors. J Surg Oncol. 2021 Dec; 124(8):1251-1260. Cruz SM, Basmaci UN, Bateni CP, Darrow MA, Judge SJ, Monjazeb AM, Thorpe SW, Humphries MD, Canter RJ. PMID: 34495553.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    23. Analysis of tumor-infiltrating NK and T cells highlights IL-15 stimulation and TIGIT blockade as a combination immunotherapy strategy for soft tissue sarcomas. J Immunother Cancer. 2020 11; 8(2). Judge SJ, Darrow MA, Thorpe SW, Gingrich AA, O'Donnell EF, Bellini AR, Sturgill IR, Vick LV, Dunai C, Stoffel KM, Lyu Y, Chen S, Cho M, Rebhun RB, Monjazeb AM, Murphy WJ, Canter RJ. PMID: 33158916; PMCID: PMC7651745.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    24. Is minimally invasive surgery of lesions in the right superior segments of the liver justified? A multi-institutional study of 245 patients. J Surg Oncol. 2020 Dec; 122(7):1428-1434. Gholami S, Judge SJ, Lee SY, Mashayekhi K, Goh BKP, Chan CY, Nuño MA, Gönen M, Balachandran VP, Allen PJ, Drebin JA, Jarnagin WR, D' Angelica MI, Kingham TP. PMID: 33459363; PMCID: PMC7978501.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    25. Minimal PD-1 expression in mouse and human NK cells under diverse conditions. J Clin Invest. 2020 06 01; 130(6):3051-3068. Judge SJ, Dunai C, Aguilar EG, Vick SC, Sturgill IR, Khuat LT, Stoffel KM, Van Dyke J, Longo DL, Darrow MA, Anderson SK, Blazar BR, Monjazeb AM, Serody JS, Canter RJ, Murphy WJ. PMID: 32134744; PMCID: PMC7260004.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    26. The Role of Palliative Surgery for Malignant Bowel Obstruction and Perforation in Advanced Microsatellite Instability-High Colorectal Carcinoma in the Era of Immunotherapy: Case Report. Front Oncol. 2020; 10:581. Judge SJ, Ji J, Liu J, Kaur M, Kim E, Gong J, Tam KW, Kirane AR, Gholami S, Canter RJ, Bold RJ, Gangi A, Fakih M, Cho M. PMID: 32373540; PMCID: PMC7186327.
      View in: PubMed   Mentions: 1  
    27. Blood and tissue biomarker analysis in dogs with osteosarcoma treated with palliative radiation and intra-tumoral autologous natural killer cell transfer. PLoS One. 2020; 15(2):e0224775. Judge SJ, Yanagisawa M, Sturgill IR, Bateni SB, Gingrich AA, Foltz JA, Lee DA, Modiano JF, Monjazeb AM, Culp WTN, Rebhun RB, Murphy WJ, Kent MS, Canter RJ. PMID: 32084139; PMCID: PMC7034869.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCellsCTClinical Trials
    28. Characterizing the Dysfunctional NK Cell: Assessing the Clinical Relevance of Exhaustion, Anergy, and Senescence. Front Cell Infect Microbiol. 2020; 10:49. Judge SJ, Murphy WJ, Canter RJ. PMID: 32117816; PMCID: PMC7031155.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    29. Morbidity, mortality and temporal trends in the surgical management of retroperitoneal sarcoma: An ACS-NSQIP follow up analysis. J Surg Oncol. 2019 Sep; 120(4):753-760. Judge SJ, Lata-Arias K, Yanagisawa M, Darrow MA, Monjazeb AM, Kirane AR, Bold RJ, Canter RJ, Canter DJ. PMID: 31355444.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    30. Bortezomib Augments Natural Killer Cell Targeting of Stem-Like Tumor Cells. Cancers (Basel). 2019 Jan 14; 11(1). Luna JI, Grossenbacher SK, Sturgill IR, Ames E, Judge SJ, Bouzid LA, Darrow MA, Murphy WJ, Canter RJ. PMID: 30646520; PMCID: PMC6356940.
      View in: PubMed   Mentions: 12  
    31. Retroperitoneal extramedullary hematopoietic pseudotumor in ataxia-telangiectasia. Rare Tumors. 2018; 10:2036361318789724. Judge SJ, Plescia TA, Bateni CP, Darrow MA, Evans CP, Canter RJ. PMID: 30046399; PMCID: PMC6056779.
      View in: PubMed   Mentions: 1  
    32. Serum C-reactive Protein and Neutrophil/Lymphocyte Ratio After Neoadjuvant Radiotherapy in Soft Tissue Sarcoma. Anticancer Res. 2018 03; 38(3):1491-1497. Yanagisawa M, Gingrich AA, Judge S, Li CS, Wang N, Thorpe SW, Kirane AR, Bold RJ, Monjazeb AM, Canter RJ. PMID: 29491077; PMCID: PMC5836802.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    33. Malignant Peritoneal Mesothelioma: Characterization of the Inflammatory Response in the Tumor Microenvironment. Ann Surg Oncol. 2016 May; 23(5):1496-500. Judge S, Thomas P, Govindarajan V, Sharma P, Loggie B. PMID: 26545374.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans