Karen E Matsukuma

Title(s)Associate Professor, Pathology and Laboratory Medicine
SchoolSchool of Medicine
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    1. Characterization of natural killer and cytotoxic T-cell immune infiltrates in pancreatic ductal adenocarcinoma. J Surg Oncol. 2024 Jan 09. Persky J, Cruz SM, Darrow MA, Judge SJ, Li Y, Bold RJ, Karnezis AN, Matsukuma KE, Qi L, Canter RJ. PMID: 38196111.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Lymphoglandular Complex-Like Colorectal Carcinoma-A Series of 20 Colorectal Cases, Including Newly Reported Features of Malignant Behavior. Am J Surg Pathol. 2024 Jan 01; 48(1):70-79. Yilmaz O, Westerhoff M, Panarelli N, Hart J, Groisman G, Ruz-Caracuel I, Loughrey M, Matsukuma K, Lee SH, Yilmaz O, Gonzalez RS, Deshpande V. PMID: 38054635.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Hepatic safety profile of pancreatic cancer‑bearing mice fed a ketogenic diet in combination with gemcitabine. Oncol Lett. 2023 Nov; 26(5):479. Cortez NE, Lanzi CR, Vahmani P, Matsukuma K, Mackenzie GG. PMID: 37818128; PMCID: PMC10561147.
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    4. Practical Guide, Challenges, and Pitfalls in Liver Fibrosis Staging. Surg Pathol Clin. 2023 Sep; 16(3):457-472. Matsukuma K, Yeh MM. PMID: 37536882.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Hirschsprung Disease for the Practicing Surgical Pathologist. Am J Clin Pathol. 2023 03 13; 159(3):228-241. Matsukuma K, Gui D, Saadai P. PMID: 36565211.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    6. Correction: A Ketogenic Diet in Combination with Gemcitabine Increases Survival in Pancreatic Cancer KPC Mice. Cancer Res Commun. 2022 Dec; 2(12):1668. Cortez NE, Lanzi CR, Hong BV, Xu J, Wang F, Chen S, Ramsey JJ, Pontifex MG, Müller M, Vauzour D, Vahmani P, Hwang CI, Matsukuma K, Mackenzie GG. PMID: 36970724; PMCID: PMC10035528.
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    7. A ketogenic diet in combination with gemcitabine increases survival in pancreatic cancer KPC mice. Cancer Res Commun. 2022 09; 2(9):951-965. Cortez NE, Rodriguez Lanzi C, Hong BV, Xu J, Wang F, Chen S, Ramsey JJ, Pontifex MG, Müller M, Vauzour D, Vahmani P, Hwang CI, Matsukuma K, Mackenzie GG. PMID: 36382086; PMCID: PMC9648418.
      View in: PubMed   Mentions: 3  Translation:Animals
    8. A phase I dose escalation, dose expansion and pharmacokinetic trial of gemcitabine and alisertib in advanced solid tumors and pancreatic cancer. Cancer Chemother Pharmacol. 2022 09; 90(3):217-228. Chen JA, Huynh JC, Wu CY, Yu AM, Matsukuma K, Semrad TJ, Gandara DR, Li T, Riess JW, Tam K, Mack PC, Martinez A, Mahaffey N, Kelly KL, Kim EJ. PMID: 35907014; PMCID: PMC9402746.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    9. Plasma Oxylipin Profile Discriminates Ethnicities in Subjects with Non-Alcoholic Steatohepatitis: An Exploratory Analysis. Metabolites. 2022 Feb 19; 12(2). Mazi TA, Borkowski K, Fiehn O, Bowlus CL, Sarkar S, Matsukuma K, Ali MR, Kieffer DA, Wan YY, Stanhope KL, Havel PJ, Newman JW, Medici V. PMID: 35208265; PMCID: PMC8875408.
      View in: PubMed   Mentions: 1  
    10. Supplementation with cyanidin and delphinidin mitigates high fat diet-induced endotoxemia and associated liver inflammation in mice. Food Funct. 2022 Jan 24; 13(2):781-794. Cremonini E, Iglesias DE, Matsukuma KE, Hester SN, Wood SM, Bartlett M, Fraga CG, Oteiza PI. PMID: 34981106.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    11. Early investigations into improving bowel and bladder function in fetal ovine myelomeningocele repair. J Pediatr Surg. 2022 May; 57(5):941-948. Theodorou CM, Jackson JE, Stokes SC, Pivetti CD, Kumar P, Paxton ZJ, Matsukuma KE, Yamashiro KJ, Reynaga L, Hyllen AA, de Lorimier AJ, Hassan M, Wang A, Farmer DL, Saadai P. PMID: 35093254; PMCID: PMC10372624.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    12. Analyzing Anatomic Pathology On-Call Summaries to Improve Resident Education. Arch Pathol Lab Med. 2022 01 01; 146(1):112-116. Liu Y, Payne-Uprichard D, Gui D, Darrow MA, Rashidi HH, Matsukuma K. PMID: 33836045.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Acute Appendicitis with Neuronal Hyperplasia and Swelling: A Novel Histologic Mimic of Appendiceal Goblet Cell Adenocarcinoma and Signet-Ring Cell Adenocarcinoma. Int J Surg Pathol. 2022 May; 30(3):278-281. Mitra A, Lee HS, Matsukuma K. PMID: 34617794.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    14. Wilson disease and the differential diagnosis of its hepatic manifestations: a narrative review of clinical, laboratory, and liver histological features. Ann Transl Med. 2021 Sep; 9(17):1394. Schroeder SM, Matsukuma KE, Medici V. PMID: 34733946; PMCID: PMC8506558.
      View in: PubMed   Mentions: 9  
    15. Non-Alcoholic Steatohepatitis Severity Associates with FGF21 Level and Kidney Glucose Uptake. Metab Syndr Relat Disord. 2021 11; 19(9):491-497. Sarkar S, Chen S, Spencer B, Situ X, Afkarian M, Matsukuma K, Corwin MT, Wang G. PMID: 34448598; PMCID: PMC10027339.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Ethnicity-specific alterations of plasma and hepatic lipidomic profiles are related to high NAFLD rate and severity in Hispanic Americans, a pilot study. Free Radic Biol Med. 2021 08 20; 172:490-502. Mazi TA, Borkowski K, Newman JW, Fiehn O, Bowlus CL, Sarkar S, Matsukuma K, Ali MR, Kieffer DA, Wan YY, Stanhope KL, Havel PJ, Medici V. PMID: 34182070; PMCID: PMC8712226.
      View in: PubMed   Mentions: 7     Fields:    
    17. Whole exome sequencing of a gut-associated lymphoid tissue neoplasm points to precursor or early form of sporadic colon carcinoma. Pathol Res Pract. 2021 Apr; 220:153406. Yaseen A, Ladenheim A, Olson KA, Libertini SJ, McPherson JD, Matsukuma K. PMID: 33740545.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Diagnosing Hirschsprung disease by detecting intestinal ganglion cells using label-free hyperspectral microscopy. Sci Rep. 2021 01 14; 11(1):1398. Soares de Oliveira MA, Galganski L, Stokes S, Chang C-, Pivetti CD, Zhang B, Matsukuma KE, Saadai P, Chan JW. PMID: 33446868; PMCID: PMC7809197.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    19. Dynamic Positron Emission Tomography/Computed Tomography Imaging Correlate of Nonalcoholic Steatohepatitis. Clin Gastroenterol Hepatol. 2021 11; 19(11):2441-2443. Sarkar S, Matsukuma KE, Spencer B, Chen S, Olson KA, Badawi RD, Corwin MT, Wang G. PMID: 33075553; PMCID: PMC10096050.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    20. Gastric Pyloric Gland Adenoma in MUTYH-Associated Polyposis. Clin Gastroenterol Hepatol. 2022 02; 20(2):A25-A26. Liu C, Matsukuma K, Tejaswi S. PMID: 33049409.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Improving the accuracy of gastrointestinal neuroendocrine tumor grading with deep learning. Sci Rep. 2020 07 06; 10(1):11064. Govind D, Jen KY, Matsukuma K, Gao G, Olson KA, Gui D, Wilding GE, Border SP, Sarder P. PMID: 32632119; PMCID: PMC7338406.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    22. MRI Radiomics for Prediction of Tumor Response and Downstaging in Rectal Cancer Patients after Preoperative Chemoradiation. Adv Radiat Oncol. 2020 Nov-Dec; 5(6):1286-1295. Chen H, Shi L, Nguyen KNB, Monjazeb AM, Matsukuma KE, Loehfelm TW, Huang H, Qiu J, Rong Y. PMID: 33305090; PMCID: PMC7718560.
      View in: PubMed   Mentions: 14  
    23. Primary Biliary Cholangitis: A Brief Overview. Clin Liver Dis (Hoboken). 2020 Mar; 15(3):100-104. Louie JS, Grandhe S, Matsukuma K, Bowlus CL. PMID: 32257120; PMCID: PMC7128028.
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    24. Eosinophilic cholangitis: A case report of diagnostically challenging eosinophilic infiltrative biliary obstruction. World J Gastrointest Endosc. 2019 Dec 16; 11(12):589-595. Dodda A, Matsukuma K, Urayama S. PMID: 31839877; PMCID: PMC6885728.
      View in: PubMed   Mentions: 4  
    25. Dual-mode emission and transmission microscopy for virtual histochemistry using hematoxylin- and eosin-stained tissue sections. Biomed Opt Express. 2019 Dec 01; 10(12):6516-6530. Fereidouni F, Todd A, Li Y, Chang CW, Luong K, Rosenberg A, Lee YJ, Chan JW, Borowsky A, Matsukuma K, Jen KY, Levenson R. PMID: 31853414; PMCID: PMC6913420.
      View in: PubMed   Mentions: 10  
    26. Colonic Angiosarcoma: A Rare Gastrointestinal Malignancy. Clin Gastroenterol Hepatol. 2020 06; 18(7):e75. Louie J, Tejaswi S, Matsukuma K. PMID: 30981006.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    27. Cholesterol crystal embolism to the gastrointestinal tract: a catastrophic case. Autops Case Rep. 2019 Apr-Jun; 9(2):e2018082. Tian M, Matsukuma KE. PMID: 31086777; PMCID: PMC6455701.
      View in: PubMed   Mentions: 2  
    28. Gastrointestinal Bleeding After Hemolytic Uremic Syndrome: A Report of Drug-associated Granulation Tissue Polyps. J Pediatr Gastroenterol Nutr. 2018 Nov; 67(5):e102-e104. Say DS, Starnes T, Matsukuma K, Nguyen S. PMID: 29851764.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    29. Update on the pathology of liver neoplasms. Ann Diagn Pathol. 2019 Feb; 38:126-137. Matsukuma KE, Yeh MM. PMID: 30597357.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    30. Precancerous neoplastic cells can move through the pancreatic ductal system. Nature. 2018 09; 561(7722):201-205. Makohon-Moore AP, Matsukuma K, Zhang M, Reiter JG, Gerold JM, Jiao Y, Sikkema L, Attiyeh MA, Yachida S, Sandone C, Hruban RH, Klimstra DS, Papadopoulos N, Nowak MA, Kinzler KW, Vogelstein B, Iacobuzio-Donahue CA. PMID: 30177826; PMCID: PMC6342205.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    31. Massive Epithelioid Hemangioendothelioma Causing Noncirrhotic Portal Hypertension. Clin Gastroenterol Hepatol. 2019 06; 17(7):A19. Taefi A, Matsukuma K, Chak E. PMID: 29609064.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    32. Synaptophysin-Ki67 double stain: a novel technique that improves interobserver agreement in the grading of well-differentiated gastrointestinal neuroendocrine tumors. Mod Pathol. 2017 04; 30(4):620-629. Matsukuma K, Olson KA, Gui D, Gandour-Edwards R, Li Y, Beckett L. PMID: 28084345; PMCID: PMC5380546.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    33. OsmoPrep-associated Gastritis: A Histopathologic Mimic of Iron Pill Gastritis and Mucosal Calcinosis. Am J Surg Pathol. 2016 11; 40(11):1550-1556. Matsukuma K, Gui D, Olson KA, Tejaswi S, Clayton EF, Thai A. PMID: 27454942; PMCID: PMC5156324.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    34. A Rare Cause of Pulmonary Nodules. Case Rep Gastroenterol. 2016 Sep-Dec; 10(3):633-639. Chew MT, Chak E, Matsukuma K. PMID: 27920654; PMCID: PMC5121564.
      View in: PubMed   Mentions: 1  
    35. Diagnosis and differential diagnosis of hepatic graft versus host disease (GVHD). J Gastrointest Oncol. 2016 Apr; 7(Suppl 1):S21-31. Matsukuma KE, Wei D, Sun K, Ramsamooj R, Chen M. PMID: 27034810; PMCID: PMC4783620.
      View in: PubMed   Mentions: 17  
    36. Predictors of Post-Operative Pain Relief in Patients with Chronic Pancreatitis Undergoing the Frey or Whipple Procedure. J Gastrointest Surg. 2016 Apr; 20(4):734-40. Sinha A, Patel YA, Cruise M, Matsukuma K, Zaheer A, Afghani E, Yadav D, Makary MA, Hirose K, Andersen DK, Singh VK. PMID: 26813017.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    37. Idelalisib-associated Enterocolitis: Clinicopathologic Features and Distinction From Other Enterocolitides. Am J Surg Pathol. 2015 Dec; 39(12):1653-60. Louie CY, DiMaio MA, Matsukuma KE, Coutre SE, Berry GJ, Longacre TA. PMID: 26426383.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    38. Abdominal CT predictors of fibrosis in patients with chronic pancreatitis undergoing surgery. Eur Radiol. 2015 May; 25(5):1339-46. Sinha A, Singh VK, Cruise M, Afghani E, Matsukuma K, Ali S, Andersen DK, Makary MA, Raman SP, Fishman EK, Zaheer A. PMID: 25471477.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    39. Extent of pancreatic fibrosis as a determinant of symptom resolution after the Frey procedure: a clinico-pathologic analysis. J Gastrointest Surg. 2013 Apr; 17(4):682-7. Cooper MA, Makary MA, Ng J, Cui Y, Singh VK, Matsukuma K, Andersen DK. PMID: 23345052.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    40. Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors. Mod Pathol. 2012 Jul; 25(7):1033-9. de Wilde RF, Heaphy CM, Maitra A, Meeker AK, Edil BH, Wolfgang CL, Ellison TA, Schulick RD, Molenaar IQ, Valk GD, Vriens MR, Borel Rinkes IH, Offerhaus GJ, Hruban RH, Matsukuma KE. PMID: 22575867; PMCID: PMC3547622.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    41. Tubular carcinoids of the appendix: the CK7/CK20 immunophenotype can be a diagnostic pitfall. J Clin Pathol. 2012 Jul; 65(7):666-8. Matsukuma KE, Montgomery EA. PMID: 22461652.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    42. Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):E252-9. Shain AH, Giacomini CP, Matsukuma K, Karikari CA, Bashyam MD, Hidalgo M, Maitra A, Pollack JR. PMID: 22233809; PMCID: PMC3277150.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansCells
    43. Hereditary diffuse gastric cancer due to a previously undescribed CDH1 splice site mutation. Hum Pathol. 2010 Aug; 41(8):1200-3. Matsukuma KE, Mullins FM, Dietz L, Zehnder JL, Ford JM, Chun NM, Schrijver I. PMID: 20624523.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    44. A key role for orphan nuclear receptor liver receptor homologue-1 in activation of fatty acid synthase promoter by liver X receptor. J Biol Chem. 2007 Jul 13; 282(28):20164-71. Matsukuma KE, Wang L, Bennett MK, Osborne TF. PMID: 17522048.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    45. Coordinated control of bile acids and lipogenesis through FXR-dependent regulation of fatty acid synthase. J Lipid Res. 2006 Dec; 47(12):2754-61. Matsukuma KE, Bennett MK, Huang J, Wang L, Gil G, Osborne TF. PMID: 16957179.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    46. Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors. J Biol Chem. 2002 Mar 29; 277(13):11019-25. Joseph SB, Laffitte BA, Patel PH, Watson MA, Matsukuma KE, Walczak R, Collins JL, Osborne TF, Tontonoz P. PMID: 11790787.
      View in: PubMed   Mentions: 225     Fields:    Translation:HumansAnimalsCells
    47. A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission. J Biol Chem. 2001 Mar 30; 276(13):10374-86. Bardwell AJ, Flatauer LJ, Matsukuma K, Thorner J, Bardwell L. PMID: 11134045; PMCID: PMC3021106.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    48. Frequent co-expression of the HOXA9 and MEIS1 homeobox genes in human myeloid leukemias. Leukemia. 1999 Dec; 13(12):1993-9. Lawrence HJ, Rozenfeld S, Cruz C, Matsukuma K, Kwong A, Kömüves L, Buchberg AM, Largman C. PMID: 10602420.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansCells
    49. Retinoic acid increases tyrosine phosphorylation of focal adhesion kinase and paxillin in MCF-7 human breast cancer cells. Cancer Res. 1999 Jan 01; 59(1):85-90. Zhu WY, Jones CS, Amin S, Matsukuma K, Haque M, Vuligonda V, Chandraratna RA, De Luca LM. PMID: 9892191.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    50. EGF-Receptor phosphorylation and signaling are targeted by H2O2 redox stress. Am J Respir Cell Mol Biol. 1998 Nov; 19(5):786-98. Goldkorn T, Balaban N, Matsukuma K, Chea V, Gould R, Last J, Chan C, Chavez C. PMID: 9806743.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    51. H2O2 acts on cellular membranes to generate ceramide signaling and initiate apoptosis in tracheobronchial epithelial cells. J Cell Sci. 1998 Nov; 111 ( Pt 21):3209-20. Goldkorn T, Balaban N, Shannon M, Chea V, Matsukuma K, Gilchrist D, Wang H, Chan C. PMID: 9763515.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    52. EGF receptor phosphorylation is affected by ionizing radiation. Biochim Biophys Acta. 1997 Oct 11; 1358(3):289-99. Goldkorn T, Balaban N, Shannon M, Matsukuma K. PMID: 9366260.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    53. Retinoic acid inhibition of cell cycle progression in MCF-7 human breast cancer cells. Exp Cell Res. 1997 Aug 01; 234(2):293-9. Zhu WY, Jones CS, Kiss A, Matsukuma K, Amin S, De Luca LM. PMID: 9260897.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    54. Induction of heat shock 70 mRNA by cadmium is mediated by glutathione suppressive and non-suppressive triggers. Biochim Biophys Acta. 1994 Sep 28; 1201(1):29-36. Abe T, Konishi T, Katoh T, Hirano H, Matsukuma K, Kashimura M, Higashi K. PMID: 7918579.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    55. [Evaluation of pre-radiotherapy staging laparotomy in cancer of the uterine cervix]. Nihon Sanka Fujinka Gakkai Zasshi. 1989 Mar; 41(3):280-6. Matsuyama T, Tsukamoto N, Matsukuma K, Kamura T, Saitou T, Kaku T, Nakano H. PMID: 2732561.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    56. [An evaluation of para-aortic and pelvic lymph node metastases in patients with endometrial carcinoma]. Gan No Rinsho. 1987 Oct; 33(13):1705-11. Tsukamoto N, Matsukuma K, Saito T, Matsuyama T, Kamura T, Kaku T, Suenaga T. PMID: 3694803.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    57. Modified VAB-3 combination chemotherapy of advanced and recurrent endodermal sinus tumors of the ovary. Gynecol Oncol. 1985 Mar; 20(3):336-45. Tsukamoto N, Imachi M, Uchino H, Ono M, Kamura T, Saito T, Matsukuma K. PMID: 2579009.
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