Gerardo G Mackenzie

Title(s)Associate Professor, Nutrition
SchoolSchool of Veterinary Medicine
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    Collapse Research 
    Collapse Research Activities and Funding
    Phospholipase D1 and pancreatic cancer
    NIH R21CA227416Sep 1, 2020 - Aug 31, 2022
    Role: Principal Investigator
    Reprogramming Tumor-Associated Macrophages in PDAC with MicroRNA Nano-Vectors
    NIH R21CA213114Aug 1, 2017 - Jul 31, 2020
    Role: Co-Principal Investigator
    A novel combination approach for pancreatic cancer prevention
    NIH R03CA181727Aug 1, 2015 - Jul 31, 2018
    Role: Principal Investigator
    Two phospho-compounds for pancreatic cancer prevention
    NIH R21CA185209Mar 26, 2015 - Feb 28, 2018
    Role: Principal Investigator
    Pancreatic cancer control by a novel combination treatment
    NIH R21CA175699Dec 5, 2014 - Nov 30, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A high-fat diet induces changes in mesenteric adipose tissue accelerating early-stage pancreatic carcinogenesis in mice. J Nutr Biochem. 2024 Jun 12; 109690. Ead AS, Wirkus J, Matsukuma K, Mackenzie GG. PMID: 38876394.
      View in: PubMed   Mentions:    Fields:    
    2. Hepatic safety profile of pancreatic cancer‑bearing mice fed a ketogenic diet in combination with gemcitabine. Oncol Lett. 2023 Nov; 26(5):479. Cortez NE, Lanzi CR, Vahmani P, Matsukuma K, Mackenzie GG. PMID: 37818128; PMCID: PMC10561147.
      View in: PubMed   Mentions:
    3. A Ketogenic Diet in Combination with Gemcitabine Mitigates Pancreatic Cancer-Associated Cachexia in Male and Female KPC Mice. Int J Mol Sci. 2023 Jun 28; 24(13). Cortez NE, Pathak S, Rodriguez Lanzi C, Hong BV, Crone R, Sule R, Wang F, Chen S, Gomes AV, Baar K, Mackenzie GG. PMID: 37445930; PMCID: PMC10341838.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    4. Chlorogenic acid combined with epigallocatechin-3-gallate mitigates D-galactose-induced gut aging in mice. Food Funct. 2023 Mar 20; 14(6):2684-2697. Wei R, Su Z, Mackenzie GG. PMID: 36752162.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    5. Correction: A Ketogenic Diet in Combination with Gemcitabine Increases Survival in Pancreatic Cancer KPC Mice. Cancer Res Commun. 2022 Dec; 2(12):1668. Cortez NE, Lanzi CR, Hong BV, Xu J, Wang F, Chen S, Ramsey JJ, Pontifex MG, Müller M, Vauzour D, Vahmani P, Hwang CI, Matsukuma K, Mackenzie GG. PMID: 36970724; PMCID: PMC10035528.
      View in: PubMed   Mentions:    Fields:    
    6. A ketogenic diet in combination with gemcitabine increases survival in pancreatic cancer KPC mice. Cancer Res Commun. 2022 09; 2(9):951-965. Cortez NE, Rodriguez Lanzi C, Hong BV, Xu J, Wang F, Chen S, Ramsey JJ, Pontifex MG, Müller M, Vauzour D, Vahmani P, Hwang CI, Matsukuma K, Mackenzie GG. PMID: 36382086; PMCID: PMC9648418.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    7. Phospho-Aspirin (MDC-22) inhibits pancreatic cancer growth in patient-derived tumor xenografts and KPC mice by targeting EGFR: Enhanced efficacy in combination with irinotecan. Neoplasia. 2022 02; 24(2):133-144. Rodriguez Lanzi C, Wei R, Luo D, Mackenzie GG. PMID: 34968866; PMCID: PMC8717147.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    8. (-)-Epigallocatechin-3-gallate mitigates cyclophosphamide-induced intestinal injury by modulating the tight junctions, inflammation and dysbiosis in mice. Food Funct. 2021 Nov 15; 12(22):11671-11685. Wei R, Liu X, Wang Y, Dong J, Wu F, Mackenzie GG, Su Z. PMID: 34730149.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    9. Hyaluronic acid nanoparticle-encapsulated microRNA-125b repolarizes tumor-associated macrophages in pancreatic cancer. Nanomedicine (Lond). 2021 10; 16(25):2291-2303. Parayath NN, Hong BV, Mackenzie GG, Amiji MM. PMID: 34579548; PMCID: PMC8493533.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    10. Ketogenic Diets in Pancreatic Cancer and Associated Cachexia: Cellular Mechanisms and Clinical Perspectives. Nutrients. 2021 Sep 15; 13(9). Cortez NE, Mackenzie GG. PMID: 34579079; PMCID: PMC8471358.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    11. Combination of miR‑143 and miR‑506 reduces lung and pancreatic cancer cell growth through the downregulation of cyclin‑dependent kinases. Oncol Rep. 2021 04; 45(4). Hossian AKMN, Mackenzie GG, Mattheolabakis G. PMID: 33649787; PMCID: PMC7876997.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    12. Impact of dietary fat composition and quantity in pancreatic carcinogenesis: Recent advances and controversies. Nutr Res. 2021 04; 88:1-18. Wirkus J, Ead AS, Mackenzie GG. PMID: 33607535.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    13. EGCG sensitizes chemotherapeutic-induced cytotoxicity by targeting the ERK pathway in multiple cancer cell lines. Arch Biochem Biophys. 2020 10 15; 692:108546. Wei R, Wirkus J, Yang Z, Machuca J, Esparza Y, Mackenzie GG. PMID: 32818507; PMCID: PMC7494570.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    14. Phospho-valproic acid (MDC-1112) reduces pancreatic cancer growth in patient-derived tumor xenografts and KPC mice: enhanced efficacy when combined with gemcitabine. Carcinogenesis. 2020 07 14; 41(7):927-939. Luo D, Digiovanni MG, Wei R, Lacomb JF, Williams JL, Rigas B, Mackenzie GG. PMID: 31584613; PMCID: PMC7951062.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    15. The inhibitory effect of ECG and EGCG dimeric procyanidins on colorectal cancer cells growth is associated with their actions at lipid rafts and the inhibition of the epidermal growth factor receptor signaling. Biochem Pharmacol. 2020 05; 175:113923. Zhu W, Li MC, Wang FR, Mackenzie GG, Oteiza PI. PMID: 32217102; PMCID: PMC7489796.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    16. Phospho-valproic acid (MDC-1112) suppresses glioblastoma growth in preclinical models through the inhibition of STAT3 phosphorylation. Carcinogenesis. 2019 12 31; 40(12):1480-1491. Luo D, Fraga-Lauhirat M, Millings J, Ho C, Villarreal EM, Fletchinger TC, Bonfiglio JV, Mata L, Nemesure MD, Bartels LE, Wang R, Rigas B, Mackenzie GG. PMID: 30994173; PMCID: PMC7967702.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    17. miRNAs in gastrointestinal diseases: can we effectively deliver RNA-based therapeutics orally? Nanomedicine (Lond). 2019 11; 14(21):2873-2889. Hossian AKMN, Mackenzie GG, Mattheolabakis G. PMID: 31735124; PMCID: PMC7026766.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    18. Targeting Glycolysis with Epigallocatechin-3-Gallate Enhances the Efficacy of Chemotherapeutics in Pancreatic Cancer Cells and Xenografts. Cancers (Basel). 2019 Oct 05; 11(10). Wei R, Hackman RM, Wang Y, Mackenzie GG. PMID: 31590367; PMCID: PMC6826788.
      View in: PubMed   Mentions: 18  
    19. DHA-SBT-1214 Taxoid Nanoemulsion and Anti-PD-L1 Antibody Combination Therapy Enhances Antitumor Efficacy in a Syngeneic Pancreatic Adenocarcinoma Model. Mol Cancer Ther. 2019 11; 18(11):1961-1972. Ahmad G, Mackenzie GG, Egan J, Amiji MM. PMID: 31439714; PMCID: PMC6825580.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    20. Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial-Mesenchymal Transition: Enhanced Efficacy when Combined with Gemcitabine. Nutrients. 2019 Aug 09; 11(8). Wei R, Penso NEC, Hackman RM, Wang Y, Mackenzie GG. PMID: 31405071; PMCID: PMC6722696.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    21. Analgesic Use and Ovarian Cancer Risk: An Analysis in the Ovarian Cancer Cohort Consortium. J Natl Cancer Inst. 2019 02 01; 111(2):137-145. Trabert B, Poole EM, White E, Visvanathan K, Adami HO, Anderson GL, Brasky TM, Brinton LA, Fortner RT, Gaudet M, Hartge P, Hoffman-Bolton J, Jones M, Lacey JV, Larsson SC, Mackenzie GG, Schouten LJ, Sandler DP, O'Brien K, Patel AV, Peters U, Prizment A, Robien K, Setiawan VW, Swerdlow A, van den Brandt PA, Weiderpass E, Wilkens LR, Wolk A, Wentzensen N, Tworoger SS, Ovarian Cancer Cohort Consortium (OC3). PMID: 29860330; PMCID: PMC6376910.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    22. Oncogenic Ras/squamous cell carcinoma antigen signaling pathway activation promotes invasiveness and lymph node metastases in papillary thyroid carcinoma. Oncol Rep. 2019 Feb; 41(2):1253-1263. Luo D, Liu Y, Lin S, Tan L, Du Z, Long M, Zhu Y, Peng X, Zong W, Mackenzie GG, Li H, Ouyang N. PMID: 30535496.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    23. Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models. Food Funct. 2018 Nov 14; 9(11):5682-5696. Wei R, Mao L, Xu P, Zheng X, Hackman RM, Mackenzie GG, Wang Y. PMID: 30310905; PMCID: PMC7480214.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    24. [Corrigendum] Phospho‑valproic acid inhibits pancreatic cancer growth in mice: Enhanced efficacy by its formulation in poly‑(L)‑lactic acid‑poly(ethylene glycol) nanoparticles. Int J Oncol. 2018 12; 53(6):2800. Mattheolabakis G, Wang R, Rigas B, Mackenzie GG. PMID: 30320367; PMCID: PMC6203162.
      View in: PubMed   Mentions:    Fields:    
    25. Analgesic Use and Ovarian Cancer Risk. Obstetrical & Gynecological Survey. 2018 Oct 1; 73(10):576-578. Trabert TB, Poole PE, White WE, Visvanathan VK, Adami AH, Anderson AG, Brasky BT, Brinton BL, Fortner FR, Gaudet GM, Hartge HP, Hoffman-Bolton HJ, Jones JM, Lacey LJ, Larsson LS, Mackenzie MG, Schouten SL, Sandler SD, O'Brien OK, Patel PA, Peters PU, Prizment PA, Robien RK, Setiawan SW, Swerdlow SA, van den Brandt vP, Weiderpass WE, Wilkens WL, Wolk WA, Wentzensen WN, Tworoger TS. .
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    26. A novel tricarbonylmethane agent (CMC2.24) reduces human pancreatic tumor growth in mice by targeting Ras. Mol Carcinog. 2018 09; 57(9):1130-1143. Mallangada NA, Vargas JM, Thomas S, DiGiovanni MG, Vaeth BM, Nemesure MD, Wang R, LaComb JF, Williams JL, Golub LM, Johnson F, Mackenzie GG. PMID: 29683208; PMCID: PMC6461215.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    27. Curcumin formulated in solid lipid nanoparticles has enhanced efficacy in Hodgkin's lymphoma in mice. Arch Biochem Biophys. 2018 06 15; 648:12-19. Guorgui J, Wang R, Mattheolabakis G, Mackenzie GG. PMID: 29679536.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    28. Pancreatic cancer: A critical review of dietary risk. Nutr Res. 2018 04; 52:1-13. Salem AA, Mackenzie GG. PMID: 29764623.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    29. Phospho-valproic acid inhibits pancreatic cancer growth in mice: enhanced efficacy by its formulation in poly-(L)-lactic acid-poly(ethylene glycol) nanoparticles. Int J Oncol. 2017 Oct; 51(4):1035-1044. Mattheolabakis G, Wang R, Rigas B, Mackenzie GG. PMID: 28849098; PMCID: PMC5592851.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    30. Aldosterone activates the oncogenic signals ERK1/2 and STAT3 via redox-regulated mechanisms. Mol Carcinog. 2017 08; 56(8):1868-1883. Queisser N, Schupp N, Schwarz E, Hartmann C, Mackenzie GG, Oteiza PI. PMID: 28272757.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    31. Zinc deficiency affects the STAT1/3 signaling pathways in part through redox-mediated mechanisms. Redox Biol. 2017 04; 11:469-481. Supasai S, Aimo L, Adamo AM, Mackenzie GG, Oteiza PI. PMID: 28086195; PMCID: PMC5228099.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    32. Phospho-Aspirin (MDC-22) Prevents Pancreatic Carcinogenesis in Mice. Cancer Prev Res (Phila). 2016 Jul; 9(7):624-34. Mattheolabakis G, Papayannis I, Yang J, Vaeth BM, Wang R, Bandovic J, Ouyang N, Rigas B, Mackenzie GG. PMID: 27138793; PMCID: PMC4930743.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    33. The novel agent phospho-glycerol-ibuprofen-amide (MDC-330) inhibits glioblastoma growth in mice: an effect mediated by cyclin D1. Carcinogenesis. 2016 Apr; 37(4):420-429. Bartels LE, Mattheolabakis G, Vaeth BM, LaComb JF, Wang R, Zhi J, Komninou D, Rigas B, Mackenzie GG. PMID: 26905586; PMCID: PMC5006213.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    34. The PI3K/Akt pathway is involved in procyanidin-mediated suppression of human colorectal cancer cell growth. Mol Carcinog. 2016 12; 55(12):2196-2209. Choy YY, Fraga M, Mackenzie GG, Waterhouse AL, Cremonini E, Oteiza PI. PMID: 26774105.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    35. Liposomal Irinotecan in the Treatment of Refractory Pancreatic Cancer. Recent Pat Anticancer Drug Discov. 2016; 11(4):376-383. Bien H, Mackenzie GG, Choi M. PMID: 27480831.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    36. Altered Interactions between the Gut Microbiome and Colonic Mucosa Precede Polyposis in APCMin/+ Mice. PLoS One. 2015; 10(6):e0127985. Son JS, Khair S, Pettet DW, Ouyang N, Tian X, Zhang Y, Zhu W, Mackenzie GG, Robertson CE, Ir D, Frank DN, Rigas B, Li E. PMID: 26121046; PMCID: PMC4485894.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    37. Gestational marginal zinc deficiency impaired fetal neural progenitor cell proliferation by disrupting the ERK1/2 signaling pathway. J Nutr Biochem. 2015 Nov; 26(11):1116-23. Nuttall JR, Supasai S, Kha J, Vaeth BM, Mackenzie GG, Adamo AM, Oteiza PI. PMID: 26153680.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    38. Phospho-aspirin (MDC-22) inhibits breast cancer in preclinical animal models: an effect mediated by EGFR inhibition, p53 acetylation and oxidative stress. BMC Cancer. 2014 Feb 28; 14:141. Huang L, Wong CC, Mackenzie GG, Sun Y, Cheng KW, Vrankova K, Alston N, Ouyang N, Rigas B. PMID: 24575839; PMCID: PMC3941604.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    39. A novel Ras inhibitor (MDC-1016) reduces human pancreatic tumor growth in mice. Neoplasia. 2013 Oct; 15(10):1184-95. Mackenzie GG, Bartels LE, Xie G, Papayannis I, Alston N, Vrankova K, Ouyang N, Rigas B. PMID: 24204197; PMCID: PMC3819634.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    40. Aerosol administration of phospho-sulindac inhibits lung tumorigenesis. Mol Cancer Ther. 2013 Aug; 12(8):1417-28. Cheng KW, Wong CC, Alston N, Mackenzie GG, Huang L, Ouyang N, Xie G, Wiedmann T, Rigas B. PMID: 23645590; PMCID: PMC3780561.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    41. Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice. PLoS One. 2013; 8(5):e61532. Mackenzie GG, Huang L, Alston N, Ouyang N, Vrankova K, Mattheolabakis G, Constantinides PP, Rigas B. PMID: 23650499; PMCID: PMC3641121.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    42. Topically applied phospho-sulindac hydrogel is efficacious and safe in the treatment of experimental arthritis in rats. Pharm Res. 2013 Jun; 30(6):1471-82. Mattheolabakis G, Mackenzie GG, Huang L, Ouyang N, Cheng KW, Rigas B. PMID: 23483440; PMCID: PMC4395004.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    43. The anticancer effect of phospho-tyrosol-indomethacin (MPI-621), a novel phosphoderivative of indomethacin: in vitro and in vivo studies. Carcinogenesis. 2013 Apr; 34(4):943-51. Zhou D, Papayannis I, Mackenzie GG, Alston N, Ouyang N, Huang L, Nie T, Wong CC, Rigas B. PMID: 23338686; PMCID: PMC3616666.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    44. Phospho-sulindac (OXT-328) inhibits the growth of human lung cancer xenografts in mice: enhanced efficacy and mitochondria targeting by its formulation in solid lipid nanoparticles. Pharm Res. 2012 Nov; 29(11):3090-101. Zhu R, Cheng KW, Mackenzie G, Huang L, Sun Y, Xie G, Vrankova K, Constantinides PP, Rigas B. PMID: 22723123; PMCID: PMC3584452.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    45. The metabolism and pharmacokinetics of phospho-sulindac (OXT-328) and the effect of difluoromethylornithine. Br J Pharmacol. 2012 Apr; 165(7):2152-66. Xie G, Nie T, Mackenzie GG, Sun Y, Huang L, Ouyang N, Alston N, Zhu C, Murray OT, Constantinides PP, Kopelovich L, Rigas B. PMID: 21955327; PMCID: PMC3413853.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    46. Phospho-ibuprofen (MDC-917) suppresses breast cancer growth: an effect controlled by the thioredoxin system. Breast Cancer Res. 2012 Jan 31; 14(1):R20. Sun Y, Rowehl LM, Huang L, Mackenzie GG, Vrankova K, Komninou D, Rigas B. PMID: 22293394; PMCID: PMC3496138.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    47. Chemotherapeutic properties of phospho-nonsteroidal anti-inflammatory drugs, a new class of anticancer compounds. Cancer Res. 2011 Dec 15; 71(24):7617-27. Huang L, Mackenzie GG, Sun Y, Ouyang N, Xie G, Vrankova K, Komninou D, Rigas B. PMID: 22025561; PMCID: PMC3242900.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    48. Oxidative stress mediates through apoptosis the anticancer effect of phospho-nonsteroidal anti-inflammatory drugs: implications for the role of oxidative stress in the action of anticancer agents. J Pharmacol Exp Ther. 2011 Sep; 338(3):775-83. Sun Y, Huang L, Mackenzie GG, Rigas B. PMID: 21646387; PMCID: PMC3164348.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    49. A deficit in zinc availability can cause alterations in tubulin thiol redox status in cultured neurons and in the developing fetal rat brain. Free Radic Biol Med. 2011 Jul 15; 51(2):480-9. Mackenzie GG, Salvador GA, Romero C, Keen CL, Oteiza PI. PMID: 21600978; PMCID: PMC3506427.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    50. Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice. Cancer Prev Res (Phila). 2011 Jul; 4(7):1052-60. Mackenzie GG, Ouyang N, Xie G, Vrankova K, Huang L, Sun Y, Komninou D, Kopelovich L, Rigas B. PMID: 21464038; PMCID: PMC3131469.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    51. The novel phospho-non-steroidal anti-inflammatory drugs, OXT-328, MDC-22 and MDC-917, inhibit adjuvant-induced arthritis in rats. Br J Pharmacol. 2011 Apr; 162(7):1521-33. Huang L, Mackenzie G, Ouyang N, Sun Y, Xie G, Johnson F, Komninou D, Rigas B. PMID: 21175575; PMCID: PMC3057290.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    52. Phospho-ibuprofen (MDC-917) is a novel agent against colon cancer: efficacy, metabolism, and pharmacokinetics in mouse models. J Pharmacol Exp Ther. 2011 Jun; 337(3):876-86. Xie G, Sun Y, Nie T, Mackenzie GG, Huang L, Kopelovich L, Komninou D, Rigas B. PMID: 21422165; PMCID: PMC3101013.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    53. Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: a redox/polyamine-dependent effect. Carcinogenesis. 2010 Nov; 31(11):1982-90. Huang L, Zhu C, Sun Y, Xie G, Mackenzie GG, Qiao G, Komninou D, Rigas B. PMID: 20627873; PMCID: PMC2966552.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    54. Phospho-sulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice. Gastroenterology. 2010 Oct; 139(4):1320-32. Mackenzie GG, Sun Y, Huang L, Xie G, Ouyang N, Gupta RC, Johnson F, Komninou D, Kopelovich L, Rigas B. PMID: 20600034; PMCID: PMC2949489.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    55. The plasma membrane plays a central role in cells response to mechanical stress. Biochim Biophys Acta. 2010 Sep; 1798(9):1739-49. Verstraeten SV, Mackenzie GG, Oteiza PI. PMID: 20599684.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    56. Gestational zinc deficiency affects the regulation of transcription factors AP-1, NF-κB and NFAT in fetal brain. J Nutr Biochem. 2010 Nov; 21(11):1069-75. Aimo L, Mackenzie GG, Keenan AH, Oteiza PI. PMID: 20092996; PMCID: PMC3506428.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    57. The role of zinc in the modulation of neuronal proliferation and apoptosis. Neurotox Res. 2010 Jan; 17(1):1-14. Adamo AM, Zago MP, Mackenzie GG, Aimo L, Keen CL, Keenan A, Oteiza PI. PMID: 19784710; PMCID: PMC2797425.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    58. The differential cell signaling effects of two positional isomers of the anticancer NO-donating aspirin. Int J Oncol. 2009 Oct; 35(4):837-44. Hua A, Mackenzie GG, Rigas B. PMID: 19724920; PMCID: PMC3565755.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    59. Dimeric procyanidins are inhibitors of NF-kappaB-DNA binding. Biochem Pharmacol. 2009 Nov 01; 78(9):1252-62. Mackenzie GG, Delfino JM, Keen CL, Fraga CG, Oteiza PI. PMID: 19591805.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    60. Phosphoaspirin (MDC-43), a novel benzyl ester of aspirin, inhibits the growth of human cancer cell lines more potently than aspirin: a redox-dependent effect. Carcinogenesis. 2009 Mar; 30(3):512-9. Zhao W, Mackenzie GG, Murray OT, Zhang Z, Rigas B. PMID: 19136474; PMCID: PMC2650796.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    61. (-)-Epicatechin and related procyanidins modulate intracellular calcium and prevent oxidation in Jurkat T cells. Free Radic Res. 2008 Oct; 42(10):864-72. Verstraeten SV, Mackenzie GG, Oteiza PI, Fraga CG. PMID: 18946795.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    62. Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells. Int J Cancer. 2008 Jul 01; 123(1):56-65. Mackenzie GG, Queisser N, Wolfson ML, Fraga CG, Adamo AM, Oteiza PI. PMID: 18386790.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    63. Dimeric procyanidin B2 inhibits constitutively active NF-kappaB in Hodgkin's lymphoma cells independently of the presence of IkappaB mutations. Biochem Pharmacol. 2008 Apr 01; 75(7):1461-71. Mackenzie GG, Adamo AM, Decker NP, Oteiza PI. PMID: 18275936.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    64. NO-Donating NSAIDs, PPARdelta, and Cancer: Does PPARdelta Contribute to Colon Carcinogenesis? PPAR Res. 2008; 2008:919572. Mackenzie GG, Rasheed S, Wertheim W, Rigas B. PMID: 18528523; PMCID: PMC2408682.
      View in: PubMed   Mentions: 4  
    65. Zinc deficiency in neuronal biology. IUBMB Life. 2007 Apr-May; 59(4-5):299-307. Mackenzie GG, Zago MP, Aimo L, Oteiza PI. PMID: 17505969.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    66. Zinc and the cytoskeleton in the neuronal modulation of transcription factor NFAT. J Cell Physiol. 2007 Jan; 210(1):246-56. Mackenzie GG, Oteiza PI. PMID: 17044076.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    67. Modulation of transcription factor NF-kappaB in Hodgkin's lymphoma cell lines: effect of (-)-epicatechin. Free Radic Res. 2006 Oct; 40(10):1086-94. Mackenzie GG, Oteiza PI. PMID: 17015253.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    68. Microtubules are required for NF-kappaB nuclear translocation in neuroblastoma IMR-32 cells: modulation by zinc. J Neurochem. 2006 Oct; 99(2):402-15. Mackenzie GG, Keen CL, Oteiza PI. PMID: 17029595.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    69. alpha-Lipoic acid and N-acetyl cysteine prevent zinc deficiency-induced activation of NF-kappaB and AP-1 transcription factors in human neuroblastoma IMR-32 cells. Free Radic Res. 2006 Jan; 40(1):75-84. Mackenzie GG, Zago MP, Erlejman AG, Aimo L, Keen CL, Oteiza PI. PMID: 16298762.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    70. Differential modulation of MAP kinases by zinc deficiency in IMR-32 cells: role of H(2)O(2). Antioxid Redox Signal. 2005 Nov-Dec; 7(11-12):1773-82. Zago MP, Mackenzie GG, Adamo AM, Keen CL, Oteiza PI. PMID: 16356139.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    71. Zinc, oxidant-triggered cell signaling, and human health. Mol Aspects Med. 2005 Aug-Oct; 26(4-5):245-55. Oteiza PI, Mackenzie GG. PMID: 16115673.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    72. Influence of zinc deficiency on cell-membrane fluidity in Jurkat, 3T3 and IMR-32 cells. Biochem J. 2004 Mar 01; 378(Pt 2):579-87. Verstraeten SV, Zago MP, MacKenzie GG, Keen CL, Oteiza PI. PMID: 14629198; PMCID: PMC1223981.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    73. Metals in neurodegeneration: involvement of oxidants and oxidant-sensitive transcription factors. Mol Aspects Med. 2004 Feb-Apr; 25(1-2):103-15. Oteiza PI, Mackenzie GG, Verstraeten SV. PMID: 15051320.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    74. Epicatechin, catechin, and dimeric procyanidins inhibit PMA-induced NF-kappaB activation at multiple steps in Jurkat T cells. FASEB J. 2004 Jan; 18(1):167-9. Mackenzie GG, Carrasquedo F, Delfino JM, Keen CL, Fraga CG, Oteiza PI. PMID: 14630700.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    75. Low intracellular zinc impairs the translocation of activated NF-kappa B to the nuclei in human neuroblastoma IMR-32 cells. J Biol Chem. 2002 Sep 13; 277(37):34610-7. Mackenzie GG, Zago MP, Keen CL, Oteiza PI. PMID: 12089148.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    76. Comparative study on the antioxidant capacity of wines and other plant-derived beverages. Ann N Y Acad Sci. 2002 May; 957:279-83. Actis-Goretta L, Mackenzie GG, Oteiza PI, Fraga CG. PMID: 12074981.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    77. Zinc status of human IMR-32 neuroblastoma cells influences their susceptibility to iron-induced oxidative stress. Dev Neurosci. 2002; 24(2-3):125-33. Mackenzie GG, Keen CL, Oteiza PI. PMID: 12401950.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
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