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Gerardo G Mackenzie

Title(s)Assistant Professor, NUTRITION
SchoolUniversity of California, Davis
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    Collapse Research 
    Collapse Research Activities and Funding
    Reprogramming Tumor-Associated Macrophages in PDAC with MicroRNA Nano-Vectors
    NIH/NCI R21CA213114Aug 1, 2017 - Jul 31, 2019
    Role: Co-Principal Investigator
    A novel combination approach for pancreatic cancer prevention
    NIH/NCI R03CA181727Aug 1, 2015 - Jul 31, 2017
    Role: Principal Investigator
    Two phospho-compounds for pancreatic cancer prevention
    NIH/NCI R21CA185209Mar 26, 2015 - Feb 28, 2017
    Role: Principal Investigator
    Pancreatic cancer control by a novel combination treatment
    NIH/NCI R21CA175699Dec 5, 2014 - Nov 30, 2016
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hossian AKMN, Mackenzie GG, Mattheolabakis G. miRNAs in gastrointestinal diseases: can we effectively deliver RNA-based therapeutics orally? Nanomedicine (Lond). 2019 Nov 18. PMID: 31735124.
      View in: PubMed
    2. Wei R, Hackman RM, Wang Y, Mackenzie GG. Targeting Glycolysis with Epigallocatechin-3-Gallate Enhances the Efficacy of Chemotherapeutics in Pancreatic Cancer Cells and Xenografts. Cancers (Basel). 2019 Oct 05; 11(10). PMID: 31590367.
      View in: PubMed
    3. Luo D, DiGiovanni MG, Wei R, LaComb JF, Williams JL, Rigas B, Mackenzie GG. Phospho-valproic acid (MDC-1112) reduces pancreatic cancer growth in patient-derived tumor xenografts and KPC mice: enhanced efficacy when combined with gemcitabine. Carcinogenesis. 2019 Oct 04. PMID: 31584613.
      View in: PubMed
    4. Ahmad G, Mackenzie GG, Egan J, Amiji MM. DHA-SBT-1214 Taxoid Nanoemulsion and Anti-PD-L1 Antibody Combination Therapy Enhances Antitumor Efficacy in a Syngeneic Pancreatic Adenocarcinoma Model. Mol Cancer Ther. 2019 Nov; 18(11):1961-1972. PMID: 31439714.
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    5. Wei R, Penso NEC, Hackman RM, Wang Y, Mackenzie GG. Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial-Mesenchymal Transition: Enhanced Efficacy when Combined with Gemcitabine. Nutrients. 2019 Aug 09; 11(8). PMID: 31405071.
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    6. Luo D, Fraga-Lauhirat M, Millings J, Ho C, Villarreal EM, Fletchinger TC, Bonfiglio JV, Mata L, Nemesure MD, Bartels LE, Wang R, Rigas B, Mackenzie GG. Phospho-valproic acid (MDC-1112) suppresses glioblastoma growth in preclinical models through the inhibition of STAT3 phosphorylation. Carcinogenesis. 2019 Apr 17. PMID: 30994173.
      View in: PubMed
    7. Trabert B, Poole EM, White E, Visvanathan K, Adami HO, Anderson GL, Brasky TM, Brinton LA, Fortner RT, Gaudet M, Hartge P, Hoffman-Bolton J, Jones M, Lacey JV, Larsson SC, Mackenzie GG, Schouten LJ, Sandler DP, O'Brien K, Patel AV, Peters U, Prizment A, Robien K, Setiawan VW, Swerdlow A, van den Brandt PA, Weiderpass E, Wilkens LR, Wolk A, Wentzensen N, Tworoger SS. Analgesic Use and Ovarian Cancer Risk: An Analysis in the Ovarian Cancer Cohort Consortium. J Natl Cancer Inst. 2019 Feb 01; 111(2):137-145. PMID: 29860330.
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    8. Luo D, Liu Y, Lin S, Tan L, Du Z, Long M, Zhu Y, Peng X, Zong W, Mackenzie GG, Li H, Ouyang N. Oncogenic Ras/squamous cell carcinoma antigen signaling pathway activation promotes invasiveness and lymph node metastases in papillary thyroid carcinoma. Oncol Rep. 2019 Feb; 41(2):1253-1263. PMID: 30535496.
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    9. Wei R, Mao L, Xu P, Zheng X, Hackman RM, Mackenzie GG, Wang Y. Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models. Food Funct. 2018 Nov 14; 9(11):5682-5696. PMID: 30310905.
      View in: PubMed
    10. Mattheolabakis G, Wang R, Rigas B, Mackenzie GG. [Corrigendum] Phospho-valproic acid inhibits pancreatic cancer growth in mice: Enhanced efficacy by its formulation in poly-(L)-lactic acid-poly(ethylene glycol) nanoparticles. Int J Oncol. 2018 12; 53(6):2800. PMID: 30320367.
      View in: PubMed
    11. Mallangada NA, Vargas JM, Thomas S, DiGiovanni MG, Vaeth BM, Nemesure MD, Wang R, LaComb JF, Williams JL, Golub LM, Johnson F, Mackenzie GG. A novel tricarbonylmethane agent (CMC2.24) reduces human pancreatic tumor growth in mice by targeting Ras. Mol Carcinog. 2018 09; 57(9):1130-1143. PMID: 29683208.
      View in: PubMed
    12. Guorgui J, Wang R, Mattheolabakis G, Mackenzie GG. Curcumin formulated in solid lipid nanoparticles has enhanced efficacy in Hodgkin's lymphoma in mice. Arch Biochem Biophys. 2018 06 15; 648:12-19. PMID: 29679536.
      View in: PubMed
    13. Salem AA, Mackenzie GG. Pancreatic cancer: A critical review of dietary risk. Nutr Res. 2018 04; 52:1-13. PMID: 29764623.
      View in: PubMed
    14. Mattheolabakis G, Wang R, Rigas B, Mackenzie GG. Phospho-valproic acid inhibits pancreatic cancer growth in mice: enhanced efficacy by its formulation in poly-(L)-lactic acid-poly(ethylene glycol) nanoparticles. Int J Oncol. 2017 Oct; 51(4):1035-1044. PMID: 28849098.
      View in: PubMed
    15. Queisser N, Schupp N, Schwarz E, Hartmann C, Mackenzie GG, Oteiza PI. Aldosterone activates the oncogenic signals ERK1/2 and STAT3 via redox-regulated mechanisms. Mol Carcinog. 2017 08; 56(8):1868-1883. PMID: 28272757.
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    16. Supasai S, Aimo L, Adamo AM, Mackenzie GG, Oteiza PI. Zinc deficiency affects the STAT1/3 signaling pathways in part through redox-mediated mechanisms. Redox Biol. 2017 04; 11:469-481. PMID: 28086195.
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    17. Mattheolabakis G, Papayannis I, Yang J, Vaeth BM, Wang R, Bandovic J, Ouyang N, Rigas B, Mackenzie GG. Phospho-Aspirin (MDC-22) Prevents Pancreatic Carcinogenesis in Mice. Cancer Prev Res (Phila). 2016 Jul; 9(7):624-34. PMID: 27138793.
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    18. Bartels LE, Mattheolabakis G, Vaeth BM, LaComb JF, Wang R, Zhi J, Komninou D, Rigas B, Mackenzie GG. The novel agent phospho-glycerol-ibuprofen-amide (MDC-330) inhibits glioblastoma growth in mice: an effect mediated by cyclin D1. Carcinogenesis. 2016 Apr; 37(4):420-429. PMID: 26905586.
      View in: PubMed
    19. Choy YY, Fraga M, Mackenzie GG, Waterhouse AL, Cremonini E, Oteiza PI. The PI3K/Akt pathway is involved in procyanidin-mediated suppression of human colorectal cancer cell growth. Mol Carcinog. 2016 12; 55(12):2196-2209. PMID: 26774105.
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    20. Bien H, Mackenzie GG, Choi M. Liposomal Irinotecan in the Treatment of Refractory Pancreatic Cancer. Recent Pat Anticancer Drug Discov. 2016; 11(4):376-383. PMID: 27480831.
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    21. Son JS, Khair S, Pettet DW, Ouyang N, Tian X, Zhang Y, Zhu W, Mackenzie GG, Robertson CE, Ir D, Frank DN, Rigas B, Li E. Altered Interactions between the Gut Microbiome and Colonic Mucosa Precede Polyposis in APCMin/+ Mice. PLoS One. 2015; 10(6):e0127985. PMID: 26121046.
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    22. Nuttall JR, Supasai S, Kha J, Vaeth BM, Mackenzie GG, Adamo AM, Oteiza PI. Gestational marginal zinc deficiency impaired fetal neural progenitor cell proliferation by disrupting the ERK1/2 signaling pathway. J Nutr Biochem. 2015 Nov; 26(11):1116-23. PMID: 26153680.
      View in: PubMed
    23. Huang L, Wong CC, Mackenzie GG, Sun Y, Cheng KW, Vrankova K, Alston N, Ouyang N, Rigas B. Phospho-aspirin (MDC-22) inhibits breast cancer in preclinical animal models: an effect mediated by EGFR inhibition, p53 acetylation and oxidative stress. BMC Cancer. 2014 Feb 28; 14:141. PMID: 24575839.
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    24. Mackenzie GG, Bartels LE, Xie G, Papayannis I, Alston N, Vrankova K, Ouyang N, Rigas B. A novel Ras inhibitor (MDC-1016) reduces human pancreatic tumor growth in mice. Neoplasia. 2013 Oct; 15(10):1184-95. PMID: 24204197.
      View in: PubMed
    25. Cheng KW, Wong CC, Alston N, Mackenzie GG, Huang L, Ouyang N, Xie G, Wiedmann T, Rigas B. Aerosol administration of phospho-sulindac inhibits lung tumorigenesis. Mol Cancer Ther. 2013 Aug; 12(8):1417-28. PMID: 23645590.
      View in: PubMed
    26. Mackenzie GG, Huang L, Alston N, Ouyang N, Vrankova K, Mattheolabakis G, Constantinides PP, Rigas B. Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice. PLoS One. 2013; 8(5):e61532. PMID: 23650499.
      View in: PubMed
    27. Mattheolabakis G, Mackenzie GG, Huang L, Ouyang N, Cheng KW, Rigas B. Topically applied phospho-sulindac hydrogel is efficacious and safe in the treatment of experimental arthritis in rats. Pharm Res. 2013 Jun; 30(6):1471-82. PMID: 23483440.
      View in: PubMed
    28. Zhou D, Papayannis I, Mackenzie GG, Alston N, Ouyang N, Huang L, Nie T, Wong CC, Rigas B. The anticancer effect of phospho-tyrosol-indomethacin (MPI-621), a novel phosphoderivative of indomethacin: in vitro and in vivo studies. Carcinogenesis. 2013 Apr; 34(4):943-51. PMID: 23338686.
      View in: PubMed
    29. Zhu R, Cheng KW, Mackenzie G, Huang L, Sun Y, Xie G, Vrankova K, Constantinides PP, Rigas B. Phospho-sulindac (OXT-328) inhibits the growth of human lung cancer xenografts in mice: enhanced efficacy and mitochondria targeting by its formulation in solid lipid nanoparticles. Pharm Res. 2012 Nov; 29(11):3090-101. PMID: 22723123.
      View in: PubMed
    30. Xie G, Nie T, Mackenzie GG, Sun Y, Huang L, Ouyang N, Alston N, Zhu C, Murray OT, Constantinides PP, Kopelovich L, Rigas B. The metabolism and pharmacokinetics of phospho-sulindac (OXT-328) and the effect of difluoromethylornithine. Br J Pharmacol. 2012 Apr; 165(7):2152-66. PMID: 21955327.
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    31. Sun Y, Rowehl LM, Huang L, Mackenzie GG, Vrankova K, Komninou D, Rigas B. Phospho-ibuprofen (MDC-917) suppresses breast cancer growth: an effect controlled by the thioredoxin system. Breast Cancer Res. 2012 Jan 31; 14(1):R20. PMID: 22293394.
      View in: PubMed
    32. Huang L, Mackenzie GG, Sun Y, Ouyang N, Xie G, Vrankova K, Komninou D, Rigas B. Chemotherapeutic properties of phospho-nonsteroidal anti-inflammatory drugs, a new class of anticancer compounds. Cancer Res. 2011 Dec 15; 71(24):7617-27. PMID: 22025561.
      View in: PubMed
    33. Sun Y, Huang L, Mackenzie GG, Rigas B. Oxidative stress mediates through apoptosis the anticancer effect of phospho-nonsteroidal anti-inflammatory drugs: implications for the role of oxidative stress in the action of anticancer agents. J Pharmacol Exp Ther. 2011 Sep; 338(3):775-83. PMID: 21646387.
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    34. Mackenzie GG, Salvador GA, Romero C, Keen CL, Oteiza PI. A deficit in zinc availability can cause alterations in tubulin thiol redox status in cultured neurons and in the developing fetal rat brain. Free Radic Biol Med. 2011 Jul 15; 51(2):480-9. PMID: 21600978.
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    35. Mackenzie GG, Ouyang N, Xie G, Vrankova K, Huang L, Sun Y, Komninou D, Kopelovich L, Rigas B. Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice. Cancer Prev Res (Phila). 2011 Jul; 4(7):1052-60. PMID: 21464038.
      View in: PubMed
    36. Huang L, Mackenzie G, Ouyang N, Sun Y, Xie G, Johnson F, Komninou D, Rigas B. The novel phospho-non-steroidal anti-inflammatory drugs, OXT-328, MDC-22 and MDC-917, inhibit adjuvant-induced arthritis in rats. Br J Pharmacol. 2011 Apr; 162(7):1521-33. PMID: 21175575.
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    37. Xie G, Sun Y, Nie T, Mackenzie GG, Huang L, Kopelovich L, Komninou D, Rigas B. Phospho-ibuprofen (MDC-917) is a novel agent against colon cancer: efficacy, metabolism, and pharmacokinetics in mouse models. J Pharmacol Exp Ther. 2011 Jun; 337(3):876-86. PMID: 21422165.
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    38. Huang L, Zhu C, Sun Y, Xie G, Mackenzie GG, Qiao G, Komninou D, Rigas B. Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: a redox/polyamine-dependent effect. Carcinogenesis. 2010 Nov; 31(11):1982-90. PMID: 20627873.
      View in: PubMed
    39. Mackenzie GG, Sun Y, Huang L, Xie G, Ouyang N, Gupta RC, Johnson F, Komninou D, Kopelovich L, Rigas B. Phospho-sulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice. Gastroenterology. 2010 Oct; 139(4):1320-32. PMID: 20600034.
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    40. Verstraeten SV, Mackenzie GG, Oteiza PI. The plasma membrane plays a central role in cells response to mechanical stress. Biochim Biophys Acta. 2010 Sep; 1798(9):1739-49. PMID: 20599684.
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    41. Aimo L, Mackenzie GG, Keenan AH, Oteiza PI. Gestational zinc deficiency affects the regulation of transcription factors AP-1, NF-?B and NFAT in fetal brain. J Nutr Biochem. 2010 Nov; 21(11):1069-75. PMID: 20092996.
      View in: PubMed
    42. Adamo AM, Zago MP, Mackenzie GG, Aimo L, Keen CL, Keenan A, Oteiza PI. The role of zinc in the modulation of neuronal proliferation and apoptosis. Neurotox Res. 2010 Jan; 17(1):1-14. PMID: 19784710.
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    43. Hua A, Mackenzie GG, Rigas B. The differential cell signaling effects of two positional isomers of the anticancer NO-donating aspirin. Int J Oncol. 2009 Oct; 35(4):837-44. PMID: 19724920.
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    44. Mackenzie GG, Delfino JM, Keen CL, Fraga CG, Oteiza PI. Dimeric procyanidins are inhibitors of NF-kappaB-DNA binding. Biochem Pharmacol. 2009 Nov 01; 78(9):1252-62. PMID: 19591805.
      View in: PubMed
    45. Zhao W, Mackenzie GG, Murray OT, Zhang Z, Rigas B. Phosphoaspirin (MDC-43), a novel benzyl ester of aspirin, inhibits the growth of human cancer cell lines more potently than aspirin: a redox-dependent effect. Carcinogenesis. 2009 Mar; 30(3):512-9. PMID: 19136474.
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    46. Verstraeten SV, Mackenzie GG, Oteiza PI, Fraga CG. (-)-Epicatechin and related procyanidins modulate intracellular calcium and prevent oxidation in Jurkat T cells. Free Radic Res. 2008 Oct; 42(10):864-72. PMID: 18946795.
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    47. Mackenzie GG, Queisser N, Wolfson ML, Fraga CG, Adamo AM, Oteiza PI. Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells. Int J Cancer. 2008 Jul 01; 123(1):56-65. PMID: 18386790.
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    48. Mackenzie GG, Adamo AM, Decker NP, Oteiza PI. Dimeric procyanidin B2 inhibits constitutively active NF-kappaB in Hodgkin's lymphoma cells independently of the presence of IkappaB mutations. Biochem Pharmacol. 2008 Apr 01; 75(7):1461-71. PMID: 18275936.
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    49. Mackenzie GG, Rasheed S, Wertheim W, Rigas B. NO-Donating NSAIDs, PPARdelta, and Cancer: Does PPARdelta Contribute to Colon Carcinogenesis? PPAR Res. 2008; 2008:919572. PMID: 18528523.
      View in: PubMed
    50. Mackenzie GG, Zago MP, Aimo L, Oteiza PI. Zinc deficiency in neuronal biology. IUBMB Life. 2007 Apr-May; 59(4-5):299-307. PMID: 17505969.
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    51. Mackenzie GG, Oteiza PI. Zinc and the cytoskeleton in the neuronal modulation of transcription factor NFAT. J Cell Physiol. 2007 Jan; 210(1):246-56. PMID: 17044076.
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    52. Mackenzie GG, Oteiza PI. Modulation of transcription factor NF-kappaB in Hodgkin's lymphoma cell lines: effect of (-)-epicatechin. Free Radic Res. 2006 Oct; 40(10):1086-94. PMID: 17015253.
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    53. Mackenzie GG, Keen CL, Oteiza PI. Microtubules are required for NF-kappaB nuclear translocation in neuroblastoma IMR-32 cells: modulation by zinc. J Neurochem. 2006 Oct; 99(2):402-15. PMID: 17029595.
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    54. Mackenzie GG, Zago MP, Erlejman AG, Aimo L, Keen CL, Oteiza PI. alpha-Lipoic acid and N-acetyl cysteine prevent zinc deficiency-induced activation of NF-kappaB and AP-1 transcription factors in human neuroblastoma IMR-32 cells. Free Radic Res. 2006 Jan; 40(1):75-84. PMID: 16298762.
      View in: PubMed
    55. Zago MP, Mackenzie GG, Adamo AM, Keen CL, Oteiza PI. Differential modulation of MAP kinases by zinc deficiency in IMR-32 cells: role of H(2)O(2). Antioxid Redox Signal. 2005 Nov-Dec; 7(11-12):1773-82. PMID: 16356139.
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    56. Oteiza PI, Mackenzie GG. Zinc, oxidant-triggered cell signaling, and human health. Mol Aspects Med. 2005 Aug-Oct; 26(4-5):245-55. PMID: 16115673.
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    57. Verstraeten SV, Zago MP, MacKenzie GG, Keen CL, Oteiza PI. Influence of zinc deficiency on cell-membrane fluidity in Jurkat, 3T3 and IMR-32 cells. Biochem J. 2004 Mar 01; 378(Pt 2):579-87. PMID: 14629198.
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    58. Oteiza PI, Mackenzie GG, Verstraeten SV. Metals in neurodegeneration: involvement of oxidants and oxidant-sensitive transcription factors. Mol Aspects Med. 2004 Feb-Apr; 25(1-2):103-15. PMID: 15051320.
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    59. Mackenzie GG, Carrasquedo F, Delfino JM, Keen CL, Fraga CG, Oteiza PI. Epicatechin, catechin, and dimeric procyanidins inhibit PMA-induced NF-kappaB activation at multiple steps in Jurkat T cells. FASEB J. 2004 Jan; 18(1):167-9. PMID: 14630700.
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    60. Mackenzie GG, Zago MP, Keen CL, Oteiza PI. Low intracellular zinc impairs the translocation of activated NF-kappa B to the nuclei in human neuroblastoma IMR-32 cells. J Biol Chem. 2002 Sep 13; 277(37):34610-7. PMID: 12089148.
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    61. Actis-Goretta L, Mackenzie GG, Oteiza PI, Fraga CG. Comparative study on the antioxidant capacity of wines and other plant-derived beverages. Ann N Y Acad Sci. 2002 May; 957:279-83. PMID: 12074981.
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    62. Mackenzie GG, Keen CL, Oteiza PI. Zinc status of human IMR-32 neuroblastoma cells influences their susceptibility to iron-induced oxidative stress. Dev Neurosci. 2002; 24(2-3):125-33. PMID: 12401950.
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