Aldrin Verno Gomes

InstitutionUniversity of California Davis
DepartmentPhysiology and Membrane Biology
Address191 Briggs Hall
CA 95616
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    The Role of the Proteasome in Troponin related Cardiomyopathies
    NIH/NHLBI R01HL096819May 1, 2010 - Apr 30, 2015
    Role: Principal Investigator
    UC Davis MARC Scholar Program
    NIH/NIGMS T34GM083894Jun 1, 2008 - May 31, 2020
    Role: Principal Investigator
    UC Davis Biology Program
    NIH/NIGMS R25GM056765Feb 1, 1998 - May 31, 2019
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yuan CC, Kazmierczak K, Liang J, Zhou Z, Yadav S, Gomes AV, Irving TC, Szczesna-Cordary D. Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modified MYL2 mice. Proc Natl Acad Sci U S A. 2018 Mar 06; 115(10):E2338-E2347. PMID: 29463717.
      View in: PubMed
    2. Inceoglu B, Bettaieb A, Haj FG, Gomes AV, Hammock BD. Modulation of mitochondrial dysfunction and endoplasmic reticulum stress are key mechanisms for the wide-ranging actions of epoxy fatty acids and soluble epoxide hydrolase inhibitors. Prostaglandins Other Lipid Mediat. 2017 Nov; 133:68-78. PMID: 28847566.
      View in: PubMed
    3. Yuan CC, Kazmierczak K, Liang J, Kanashiro-Takeuchi R, Irving TC, Gomes AV, Wang Y, Burghardt TP, Szczesna-Cordary D. Hypercontractile mutant of ventricular myosin essential light chain leads to disruption of sarcomeric structure and function and results in restrictive cardiomyopathy in mice. Cardiovasc Res. 2017 Aug 01; 113(10):1124-1136. PMID: 28371863.
      View in: PubMed
    4. Gilda JE, Gomes AV. Proteasome dysfunction in cardiomyopathies. J Physiol. 2017 Jun 15; 595(12):4051-4071. PMID: 28181243.
      View in: PubMed
    5. Wagner K, Gilda J, Yang J, Wan D, Morisseau C, Gomes AV, Hammock BD. Soluble epoxide hydrolase inhibition alleviates neuropathy in Akita (Ins2 Akita) mice. Behav Brain Res. 2017 05 30; 326:69-76. PMID: 28259677.
      View in: PubMed
    6. Nguyen S, Siu R, Dewey S, Cui Z, Gomes AV. Amino Acid Changes at Arginine 204 of Troponin I Result in Increased Calcium Sensitivity of Force Development. Front Physiol. 2016; 7:520. PMID: 27895589.
      View in: PubMed
    7. Ghosh R, Goswami SK, Feitoza LF, Hammock B, Gomes AV. Diclofenac induces proteasome and mitochondrial dysfunction in murine cardiomyocytes and hearts. Int J Cardiol. 2016 Nov 15; 223:923-935. PMID: 27589040.
      View in: PubMed
    8. Ghosh R, Hwang SM, Cui Z, Gilda JE, Gomes AV. Different effects of the nonsteroidal anti-inflammatory drugs meclofenamate sodium and naproxen sodium on proteasome activity in cardiac cells. J Mol Cell Cardiol. 2016 05; 94:131-144. PMID: 27049794.
      View in: PubMed
    9. Gilda JE, Lai X, Witzmann FA, Gomes AV. Delineation of Molecular Pathways Involved in Cardiomyopathies Caused by Troponin T Mutations. Mol Cell Proteomics. 2016 06; 15(6):1962-81. PMID: 27022107.
      View in: PubMed
    10. Gilda JE, Xu Q, Martinez ME, Nguyen ST, Chase PB, Gomes AV. The functional significance of the last 5 residues of the C-terminus of cardiac troponin I. Arch Biochem Biophys. 2016 07 01; 601:88-96. PMID: 26919894; PMCID: PMC4899223 [Available on 07/01/17].
    11. West DW, Baehr LM, Marcotte GR, Chason CM, Tolento L, Gomes AV, Bodine SC, Baar K. Acute resistance exercise activates rapamycin-sensitive and -insensitive mechanisms that control translational activity and capacity in skeletal muscle. J Physiol. 2016 Jan 15; 594(2):453-68. PMID: 26548696; PMCID: PMC4713726 [Available on 01/15/17].
    12. Gomes AV, Kazmierczak K, Cheah JX, Gilda JE, Yuan CC, Zhou Z, Szczesna-Cordary D. Proteomic analysis of physiological versus pathological cardiac remodeling in animal models expressing mutations in myosin essential light chains. J Muscle Res Cell Motil. 2015 Dec; 36(6):447-61. PMID: 26668058; PMCID: PMC4847725 [Available on 12/14/16].
    13. Gomes AV, Rajasekaran NS, Pi X. Redox Signaling and the Cardiovascular and Skeletal Muscle System. Oxid Med Cell Longev. 2015; 2015:849095. PMID: 26523200; PMCID: PMC4617440.
    14. Ghosh R, Alajbegovic A, Gomes AV. NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species. Oxid Med Cell Longev. 2015; 2015:536962. PMID: 26457127; PMCID: PMC4592725.
    15. Gilda JE, Ghosh R, Cheah JX, West TM, Bodine SC, Gomes AV. Western Blotting Inaccuracies with Unverified Antibodies: Need for a Western Blotting Minimal Reporting Standard (WBMRS). PLoS One. 2015; 10(8):e0135392. PMID: 26287535.
      View in: PubMed
    16. Gilda JE, Gomes AV. Western blotting using in-gel protein labeling as a normalization control: stain-free technology. Methods Mol Biol. 2015; 1295:381-91. PMID: 25820735.
      View in: PubMed
    17. Ghosh R, Gilda JE, Gomes AV. The necessity of and strategies for improving confidence in the accuracy of western blots. Expert Rev Proteomics. 2014 Oct; 11(5):549-60. PMID: 25059473; PMCID: PMC4791038.
    18. Wecksler AT, Hwang SH, Wettersten HI, Gilda JE, Patton A, Leon LJ, Carraway KL, Gomes AV, Baar K, Weiss RH, Hammock BD. Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB. Anticancer Drugs. 2014 Apr; 25(4):433-46. PMID: 24525589; PMCID: PMC3947856.
    19. Puglisi JL, Goldspink PH, Gomes AV, Utter MS, Bers DM, Solaro RJ. Influence of a constitutive increase in myofilament Ca(2+)-sensitivity on Ca(2+)-fluxes and contraction of mouse heart ventricular myocytes. Arch Biochem Biophys. 2014 Jun 15; 552-553:50-9. PMID: 24480308; PMCID: PMC4043955.
    20. Gomes AV. Genetics of proteasome diseases. Scientifica (Cairo). 2013; 2013:637629. PMID: 24490108; PMCID: PMC3892944.
    21. Cui Z, Hwang SM, Gomes AV. Identification of the immunoproteasome as a novel regulator of skeletal muscle differentiation. Mol Cell Biol. 2014 Jan; 34(1):96-109. PMID: 24164898; PMCID: PMC3911280.
    22. Cui Z, Scruggs SB, Gilda JE, Ping P, Gomes AV. Regulation of cardiac proteasomes by ubiquitination, SUMOylation, and beyond. J Mol Cell Cardiol. 2014 Jun; 71:32-42. PMID: 24140722.
      View in: PubMed
    23. Cui Z, Gilda JE, Gomes AV. Crude and purified proteasome activity assays are affected by type of microplate. Anal Biochem. 2014 Feb 01; 446:44-52. PMID: 24141075; PMCID: PMC3901411.
    24. Dewey S, Lai X, Witzmann FA, Sohal M, Gomes AV. Proteomic analysis of hearts from Akita mice suggests that increases in soluble epoxide hydrolase and antioxidative programming are key changes in early stages of diabetic cardiomyopathy. J Proteome Res. 2013 Sep 06; 12(9):3920-33. PMID: 23848590.
      View in: PubMed
    25. Gilda JE, Gomes AV. Stain-Free total protein staining is a superior loading control to ß-actin for Western blots. Anal Biochem. 2013 Sep 15; 440(2):186-8. PMID: 23747530; PMCID: PMC3809032.
    26. Rajagopalan V, Zhao M, Reddy S, Fajardo G, Wang X, Dewey S, Gomes AV, Bernstein D. Altered ubiquitin-proteasome signaling in right ventricular hypertrophy and failure. Am J Physiol Heart Circ Physiol. 2013 Aug 15; 305(4):H551-62. PMID: 23729213; PMCID: PMC3891246.
    27. Gilda JE, Gomes AV. How phosphorylated can it get? Cardiac myosin binding protein C phosphorylation in heart failure. J Mol Cell Cardiol. 2013 Sep; 62:108-10. PMID: 23732927.
      View in: PubMed
    28. Szczesna-Cordary D, Morimoto S, Gomes AV, Moore JR. Cardiomyopathies: classification, clinical characterization, and functional phenotypes. Biochem Res Int. 2012; 2012:870942. PMID: 23304510; PMCID: PMC3529434.
    29. Iorga A, Dewey S, Partow-Navid R, Gomes AV, Eghbali M. Pregnancy is associated with decreased cardiac proteasome activity and oxidative stress in mice. PLoS One. 2012; 7(11):e48601. PMID: 23166589; PMCID: PMC3499532.
    30. Gomes AV, Waddell DS, Siu R, Stein M, Dewey S, Furlow JD, Bodine SC. Upregulation of proteasome activity in muscle RING finger 1-null mice following denervation. FASEB J. 2012 Jul; 26(7):2986-99. PMID: 22508689; PMCID: PMC3382096.
    31. Xu Q, Cui Z, Venkatraman G, Gomes AV. The use of biophysical proteomic techniques in advancing our understanding of diseases. Biophys Rev. 2012 Jun; 4(2):125-135. PMID: 28510094.
      View in: PubMed
    32. Hwee DT, Gomes AV, Bodine SC. Cardiac proteasome activity in muscle ring finger-1 null mice at rest and following synthetic glucocorticoid treatment. Am J Physiol Endocrinol Metab. 2011 Nov; 301(5):E967-77. PMID: 21828340; PMCID: PMC3214003.
    33. Xu Q, Dewey S, Nguyen S, Gomes AV. Malignant and benign mutations in familial cardiomyopathies: insights into mutations linked to complex cardiovascular phenotypes. J Mol Cell Cardiol. 2010 May; 48(5):899-909. PMID: 20298698.
      View in: PubMed
    34. Gomes AV, Young GW, Wang Y, Zong C, Eghbali M, Drews O, Lu H, Stefani E, Ping P. Contrasting proteome biology and functional heterogeneity of the 20 S proteasome complexes in mammalian tissues. Mol Cell Proteomics. 2009 Feb; 8(2):302-15. PMID: 18931337; PMCID: PMC2634581.
    35. Wen Y, Pinto JR, Gomes AV, Xu Y, Wang Y, Wang Y, Potter JD, Kerrick WG. Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic mice. J Biol Chem. 2008 Jul 18; 283(29):20484-94. PMID: 18430738; PMCID: PMC2459290.
    36. Gomes AV, Potter JD. Cellular and molecular aspects of familial hypertrophic cardiomyopathy caused by mutations in the cardiac troponin I gene. Mol Cell Biochem. 2004 08; 263(1-2):99-114. PMID: 15524171.
      View in: PubMed
    37. Venkatraman G, Harada K, Gomes AV, Kerrick WG, Potter JD. Different functional properties of troponin T mutants that cause dilated cardiomyopathy. J Biol Chem. 2003 Oct 24; 278(43):41670-6. PMID: 12923187.
      View in: PubMed
    38. Gomes AV, Potter JD, Szczesna-Cordary D. The role of troponins in muscle contraction. IUBMB Life. 2002 Dec; 54(6):323-33. PMID: 12665242.
      View in: PubMed
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