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Eleonora Grandi

TitleASST PROF-HCOMP
InstitutionUniversity of California Davis
DepartmentPharmacology
AddressTupper Hall 2427
CA 95616
Phone530-752-4780
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ni H, Morotti S, Grandi E. A Heart for Diversity: Simulating Variability in Cardiac Arrhythmia Research. Front Physiol. 2018; 9:958. PMID: 30079031.
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    2. Morotti S, Grandi E. Quantitative systems models illuminate arrhythmia mechanisms in heart failure: Role of the Na+ -Ca2+ -Ca2+ /calmodulin-dependent protein kinase II-reactive oxygen species feedback. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul 17; e1434. PMID: 30015404.
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    3. Grandi E, Morotti S, Pueyo E, Rodriguez B. Editorial: Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond. Front Physiol. 2018; 9:678. PMID: 29937733.
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    4. Grandi E. Keeping it short and (not so) simple: characterizing hERG kinetics with sinusoidal waves. J Physiol. 2018 May 15; 596(10):1783-1784. PMID: 29521425.
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    5. Ortega FA, Grandi E, Krogh-Madsen T, Christini DJ. Applications of Dynamic Clamp to Cardiac Arrhythmia Research: Role in Drug Target Discovery and Safety Pharmacology Testing. Front Physiol. 2017; 8:1099. PMID: 29354069.
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    6. Vaidyanathan R, Van Ert H, Haq KT, Morotti S, Esch S, McCune EC, Grandi E, Eckhardt LL. Inward Rectifier Potassium Channels (Kir2.x) and Caveolin-3 Domain-Specific Interaction: Implications for Purkinje Cell-Dependent Ventricular Arrhythmias. Circ Arrhythm Electrophysiol. 2018 Jan; 11(1):e005800. PMID: 29326130.
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    7. Ellinwood N, Dobrev D, Morotti S, Grandi E. In Silico Assessment of Efficacy and Safety of IKur Inhibitors in Chronic Atrial Fibrillation: Role of Kinetics and State-Dependence of Drug Binding. Front Pharmacol. 2017; 8:799. PMID: 29163179.
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    8. Grandi E, Dobrev D. Non-ion channel therapeutics for heart failure and atrial fibrillation: Are CaMKII inhibitors ready for clinical use? J Mol Cell Cardiol. 2017 Oct 25. PMID: 29079077.
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    9. Lombardi C, Artuso E, Grandi E, Lolli M, Spyrakis F, Priola E, Prandi C. Correction: Recent advances in the synthesis of analogues of phytohormones strigolactones with ring-closing metathesis as a key step. Org Biomol Chem. 2017 Oct 04; 15(38):8232. PMID: 28932861.
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    10. Lombardi C, Artuso E, Grandi E, Lolli M, Spirakys F, Priola E, Prandi C. Recent advances in the synthesis of analogues of phytohormones strigolactones with ring-closing metathesis as a key step. Org Biomol Chem. 2017 Oct 04; 15(38):8218-8231. PMID: 28880031.
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    11. Ellinwood N, Dobrev D, Morotti S, Grandi E. Erratum: "Revealing kinetics and state-dependent binding properties of IKur-targeting drugs that maximize atrial fibrillation selectivity" [Chaos 27, 093918 (2017)]. Chaos. 2017 Oct; 27(10):109902. PMID: 29092428.
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    12. Ellinwood N, Dobrev D, Morotti S, Grandi E. Revealing kinetics and state-dependent binding properties of IKur-targeting drugs that maximize atrial fibrillation selectivity. Chaos. 2017 Sep; 27(9):093918. PMID: 28964116.
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    13. Surdo NC, Berrera M, Koschinski A, Brescia M, Machado MR, Carr C, Wright P, Gorelik J, Morotti S, Grandi E, Bers DM, Pantano S, Zaccolo M. FRET biosensor uncovers cAMP nano-domains at ß-adrenergic targets that dictate precise tuning of cardiac contractility. Nat Commun. 2017 Apr 20; 8:15031. PMID: 28425435.
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    14. Bartos DC, Morotti S, Ginsburg KS, Grandi E, Bers DM. Quantitative analysis of the Ca2+ -dependent regulation of delayed rectifier K+ current IKs in rabbit ventricular myocytes. J Physiol. 2017 Apr 01; 595(7):2253-2268. PMID: 28008618.
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    15. Morotti S, Nieves-Cintrón M, Nystoriak MA, Navedo MF, Grandi E. Predominant contribution of L-type Cav1.2 channel stimulation to impaired intracellular calcium and cerebral artery vasoconstriction in diabetic hyperglycemia. Channels (Austin). 2017 Jul 04; 11(4):340-346. PMID: 28631947.
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    16. Nystoriak MA, Nieves-Cintrón M, Patriarchi T, Buonarati OR, Prada MP, Morotti S, Grandi E, Fernandes JD, Forbush K, Hofmann F, Sasse KC, Scott JD, Ward SM, Hell JW, Navedo MF. Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes. Sci Signal. 2017 Jan 24; 10(463). PMID: 28119464.
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    17. Grandi E. Size matters, proportion too: coupling of experiments and theory reveals relative roles of K+ channels in action potential stability. J Physiol. 2017 Apr 01; 595(7):2319-2320. PMID: 28004403.
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    18. Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, Bers DM, Nerbonne JM. Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics. J Physiol. 2017 Apr 01; 595(7):2229-2252. PMID: 27808412.
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    19. Morotti S, Grandi E. Logistic regression analysis of populations of electrophysiological models to assess proarrythmic risk. MethodsX. 2017; 4:25-34. PMID: 28116246.
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    20. Grandi E, Sanguinetti MC, Bartos DC, Bers DM, Chen-Izu Y, Chiamvimonvat N, Colecraft HM, Delisle BP, Heijman J, Navedo MF, Noskov S, Proenza C, Vandenberg JI, Yarov-Yarovoy V. Potassium channels in the heart: structure, function and regulation. J Physiol. 2017 Apr 01; 595(7):2209-2228. PMID: 27861921.
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    21. Grandi E, Maleckar MM. Anti-arrhythmic strategies for atrial fibrillation: The role of computational modeling in discovery, development, and optimization. Pharmacol Ther. 2016 Dec; 168:126-142. PMID: 27612549.
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    22. Yang PC, Moreno JD, Miyake CY, Vaughn-Behrens SB, Jeng MT, Grandi E, Wehrens XH, Noskov SY, Clancy CE. In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia. J Physiol. 2016 Feb 01; 594(3):567-93. PMID: 26515697; PMCID: PMC4784170.
    23. Xie Y, Liao Z, Grandi E, Shiferaw Y, Bers DM. Slow [Na]i Changes and Positive Feedback Between Membrane Potential and [Ca]i Underlie Intermittent Early Afterdepolarizations and Arrhythmias. Circ Arrhythm Electrophysiol. 2015 Dec; 8(6):1472-80. PMID: 26407967.
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    24. Morotti S, McCulloch AD, Bers DM, Edwards AG, Grandi E. Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes. J Mol Cell Cardiol. 2016 07; 96:63-71. PMID: 26241847.
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    25. Bartos DC, Grandi E, Ripplinger CM. Ion Channels in the Heart. Compr Physiol. 2015 Jul 01; 5(3):1423-64. PMID: 26140724; PMCID: PMC4516287.
    26. Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM. Na+ channel function, regulation, structure, trafficking and sequestration. J Physiol. 2015 Mar 15; 593(6):1347-60. PMID: 25772290.
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    27. Negroni JA, Morotti S, Lascano EC, Gomes AV, Grandi E, Puglisi JL, Bers DM. ß-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model. J Mol Cell Cardiol. 2015 Apr; 81:162-75. PMID: 25724724; PMCID: PMC4380575.
    28. Edwards AG, Grandi E, Hake JE, Patel S, Li P, Miyamoto S, Omens JH, Heller Brown J, Bers DM, McCulloch AD. Nonequilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1205-13. PMID: 25236710; PMCID: PMC4301603.
    29. Grandi E, Edwards AG, Herren AW, Bers DM. CaMKII comes of age in cardiac health and disease. Front Pharmacol. 2014; 5:154. PMID: 25071573; PMCID: PMC4080132.
    30. Grandi E, Herren AW. CaMKII-dependent regulation of cardiac Na(+) homeostasis. Front Pharmacol. 2014; 5:41. PMID: 24653702; PMCID: PMC3948048.
    31. Xie Y, Grandi E, Bers DM, Sato D. How does ß-adrenergic signalling affect the transitions from ventricular tachycardia to ventricular fibrillation? Europace. 2014 Mar; 16(3):452-7. PMID: 24569900; PMCID: PMC3934848.
    32. Moreno JD, Yang PC, Bankston JR, Grandi E, Bers DM, Kass RS, Clancy CE. Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening. Circ Res. 2013 Sep 13; 113(7):e50-e61. PMID: 23897695; PMCID: PMC3896218.
    33. Herren AW, Bers DM, Grandi E. Post-translational modifications of the cardiac Na channel: contribution of CaMKII-dependent phosphorylation to acquired arrhythmias. Am J Physiol Heart Circ Physiol. 2013 Aug 15; 305(4):H431-45. PMID: 23771687; PMCID: PMC3891248.
    34. Xie Y, Grandi E, Puglisi JL, Sato D, Bers DM. ß-adrenergic stimulation activates early afterdepolarizations transiently via kinetic mismatch of PKA targets. J Mol Cell Cardiol. 2013 May; 58:153-61. PMID: 23481579; PMCID: PMC3628092.
    35. Morotti S, Grandi E, Summa A, Ginsburg KS, Bers DM. Theoretical study of L-type Ca(2+) current inactivation kinetics during action potential repolarization and early afterdepolarizations. J Physiol. 2012 Sep 15; 590(18):4465-81. PMID: 22586219; PMCID: PMC3477752.
    36. Grandi E, Workman AJ, Pandit SV. Altered Excitation-Contraction Coupling in Human Chronic Atrial Fibrillation. J Atr Fibrillation. 2012 Apr-May; 4(6):495. PMID: 28496736.
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    37. Grandi E, Pandit SV, Voigt N, Workman AJ, Dobrev D, Jalife J, Bers DM. Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation. Circ Res. 2011 Oct 14; 109(9):1055-66. PMID: 21921263; PMCID: PMC3208665.
    38. Bers DM, Grandi E. Human atrial fibrillation: insights from computational electrophysiological models. Trends Cardiovasc Med. 2011 Jul; 21(5):145-50. PMID: 22732550; PMCID: PMC3384487.
    39. Wu L, Ma J, Li H, Wang C, Grandi E, Zhang P, Luo A, Bers DM, Shryock JC, Belardinelli L. Late sodium current contributes to the reverse rate-dependent effect of IKr inhibition on ventricular repolarization. Circulation. 2011 Apr 26; 123(16):1713-20. PMID: 21482963; PMCID: PMC4028960.
    40. Wagner S, Ruff HM, Weber SL, Bellmann S, Sowa T, Schulte T, Anderson ME, Grandi E, Bers DM, Backs J, Belardinelli L, Maier LS. Reactive oxygen species-activated Ca/calmodulin kinase IId is required for late I(Na) augmentation leading to cellular Na and Ca overload. Circ Res. 2011 Mar 04; 108(5):555-65. PMID: 21252154; PMCID: PMC3065330.
    41. Grandi E, Morotti S, Ginsburg KS, Severi S, Bers DM. Interplay of voltage and Ca-dependent inactivation of L-type Ca current. Prog Biophys Mol Biol. 2010 Sep; 103(1):44-50. PMID: 20184915; PMCID: PMC2907421.
    42. Grandi E, Pasqualini FS, Bers DM. A novel computational model of the human ventricular action potential and Ca transient. J Mol Cell Cardiol. 2010 Jan; 48(1):112-21. PMID: 19835882; PMCID: PMC2813400.
    43. Bers DM, Grandi E. Calcium/calmodulin-dependent kinase II regulation of cardiac ion channels. J Cardiovasc Pharmacol. 2009 Sep; 54(3):180-7. PMID: 19333131; PMCID: PMC2784004.
    44. Wagner S, Hacker E, Grandi E, Weber SL, Dybkova N, Sossalla S, Sowa T, Fabritz L, Kirchhof P, Bers DM, Maier LS. Ca/calmodulin kinase II differentially modulates potassium currents. Circ Arrhythm Electrophysiol. 2009 Jun; 2(3):285-94. PMID: 19808479; PMCID: PMC2734104.
    45. Grandi E, Pasqualini FS, Pes C, Corsi C, Zaza A, Severi S. Theoretical investigation of action potential duration dependence on extracellular Ca2+ in human cardiomyocytes. J Mol Cell Cardiol. 2009 Mar; 46(3):332-42. PMID: 19121322.
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    46. Grandi E, Govoni M, Furini S, Severi S, Giordano E, Santoro A, Cavalcanti S. Induction of NO synthase 2 in ventricular cardiomyocytes incubated with a conventional bicarbonate dialysis bath. Nephrol Dial Transplant. 2008 Jul; 23(7):2192-7. PMID: 18281316.
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    47. Santoro A, Mancini E, London G, Mercadal L, Fessy H, Perrone B, Cagnoli L, Grandi E, Severi S, Cavalcanti S. Patients with complex arrhythmias during and after haemodialysis suffer from different regimens of potassium removal. Nephrol Dial Transplant. 2008 Apr; 23(4):1415-21. PMID: 18065796.
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    48. Severi S, Grandi E, Pes C, Badiali F, Grandi F, Santoro A. Calcium and potassium changes during haemodialysis alter ventricular repolarization duration: in vivo and in silico analysis. Nephrol Dial Transplant. 2008 Apr; 23(4):1378-86. PMID: 18045821.
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    49. Grandi E, Puglisi JL, Wagner S, Maier LS, Severi S, Bers DM. Simulation of Ca-calmodulin-dependent protein kinase II on rabbit ventricular myocyte ion currents and action potentials. Biophys J. 2007 Dec 01; 93(11):3835-47. PMID: 17704163; PMCID: PMC2084250.
    50. Vecchietti S, Grandi E, Severi S, Rivolta I, Napolitano C, Priori SG, Cavalcanti S. In silico assessment of Y1795C and Y1795H SCN5A mutations: implication for inherited arrhythmogenic syndromes. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1):H56-65. PMID: 16980337.
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    51. Severi S, Ciandrini A, Grandi E, Cavalcanti S, Bini S, Badiali F, Gattiani A, Cagnoli L. Cardiac response to hemodialysis with different cardiovascular tolerance: heart rate variability and QT interval analysis. Hemodial Int. 2006 Jul; 10(3):287-93. PMID: 16805891.
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