Eleonora Grandi

Title(s)Associate Professor, Pharmacology
SchoolUniversity of California, Davis
AddressTupper Hall 2427
CA 95616
Phone530-752-4780
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    Collapse Research 
    Collapse Research Activities and Funding
    Development of the Predictive NeuroCardiovascular Simulator
    NIH OT2OD026580Aug 1, 2018 - Jul 31, 2022
    Role: Co-Principal Investigator
    Perturbed Sodium and Calcium Fluxes in Atrial Fibrillation
    NIH R01HL131517Jun 1, 2016 - Jul 31, 2025
    Role: Principal Investigator
    Systems Approach to understanding Excitation-Coupling and Cardiac Arrhythmias
    NIH R13HL132515Mar 2, 2016 - Feb 28, 2017
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Enhancing the Peroxygenase Activity of a Cofactor-Independent Peroxyzyme by Directed Evolution Enabling Gram-Scale Epoxide Synthesis. Chemistry. 2022 Jul 21. Sigmund MC, Xu G, Grandi E, Poelarends GJ. PMID: 35861144.
      View in: PubMed   Mentions:    Fields:    
    2. TGF-β1-induced endothelial-mesenchymal transition: a potential contributor to fibrotic remodeling in atrial fibrillation? J Clin Invest. 2022 Jul 01; 132(13). Saljic A, Grandi E, Dobrev D. PMID: 35775488; PMCID: PMC9246376.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Quantitative cross-species translators of cardiac myocyte electrophysiology: Model training, experimental validation, and applications. Sci Adv. 2021 Nov 19; 7(47):eabg0927. Morotti S, Liu C, Hegyi B, Ni H, Fogli Iseppe A, Wang L, Pritoni M, Ripplinger CM, Bers DM, Edwards AG, Grandi E. PMID: 34788089; PMCID: PMC8598003.
      View in: PubMed   Mentions: 2     Fields:    
    4. Bidirectional flow of the funny current (If) during the pacemaking cycle in murine sinoatrial node myocytes. Proc Natl Acad Sci U S A. 2021 07 13; 118(28). Peters CH, Liu PW, Morotti S, Gantz SC, Grandi E, Bean BP, Proenza C. PMID: 34260402; PMCID: PMC8285948.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    5. Intracellular Na+ Modulates Pacemaking Activity in Murine Sinoatrial Node Myocytes: An In Silico Analysis. Int J Mol Sci. 2021 May 26; 22(11). Morotti S, Ni H, Peters CH, Rickert C, Asgari-Targhi A, Sato D, Glukhov AV, Proenza C, Grandi E. PMID: 34073281; PMCID: PMC8198068.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    6. Sex-Specific Classification of Drug-Induced Torsade de Pointes Susceptibility Using Cardiac Simulations and Machine Learning. Clin Pharmacol Ther. 2021 08; 110(2):380-391. Fogli Iseppe A, Ni H, Zhu S, Zhang X, Coppini R, Yang PC, Srivatsa U, Clancy CE, Edwards AG, Morotti S, Grandi E. PMID: 33772748; PMCID: PMC8316283.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    7. Computational models of cardiovascular regulatory mechanisms. J Mol Cell Cardiol. 2021 06; 155:111. McCulloch AD, Grandi E, Saucerman JJ. PMID: 33647311.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Populations of in silico myocytes and tissues reveal synergy of multiatrial-predominant K+ -current block in atrial fibrillation. Br J Pharmacol. 2020 10; 177(19):4497-4515. Ni H, Fogli Iseppe A, Giles WR, Narayan SM, Zhang H, Edwards AG, Morotti S, Grandi E. PMID: 32667679; PMCID: PMC7484508.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    9. Mechanisms of Cav3-associated arrhythmia: Protein or microdomain dysfunction? Int J Cardiol. 2020 12 01; 320:97-99. Zaza A, Grandi E. PMID: 32634502; PMCID: PMC7577955.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. GRK5 Controls SAP97-Dependent Cardiotoxic β1 Adrenergic Receptor-CaMKII Signaling in Heart Failure. Circ Res. 2020 08 28; 127(6):796-810. Xu B, Li M, Wang Y, Zhao M, Morotti S, Shi Q, Wang Q, Barbagallo F, Teoh JP, Reddy GR, Bayne EF, Liu Y, Shen A, Puglisi JL, Ge Y, Li J, Grandi E, Nieves-Cintron M, Xiang YK. PMID: 32507058; PMCID: PMC7484403.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    11. Atrial fibrillation in a dish: insights into atrial arrhythmogenesis from induced pluripotent stem cell-derived cardiomyocytes. Cardiovasc Res. 2020 05 01; 116(6):1089-1091. Grandi E, Dobrev D. PMID: 31860074; PMCID: PMC7177502.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    12. Hypokalemia Promotes Arrhythmia by Distinct Mechanisms in Atrial and Ventricular Myocytes. Circ Res. 2020 03 27; 126(7):889-906. Tazmini K, Frisk M, Lewalle A, Laasmaa M, Morotti S, Lipsett DB, Manfra O, Skogestad J, Aronsen JM, Sejersted OM, Sjaastad I, Edwards AG, Grandi E, Niederer SA, Øie E, Louch WE. PMID: 32070187; PMCID: PMC7098435.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    13. Engineered C-N Lyase: Enantioselective Synthesis of Chiral Synthons for Artificial Dipeptide Sweeteners. Angew Chem Int Ed Engl. 2020 01 02; 59(1):429-435. Zhang J, Grandi E, Fu H, Saravanan T, Bothof L, Tepper PG, Thunnissen AWH, Poelarends GJ. PMID: 31625664; PMCID: PMC6973171.
      View in: PubMed   Mentions: 4     Fields:    
    14. General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy. Clin Pharmacol Ther. 2020 01; 107(1):102-111. Li Z, Mirams GR, Yoshinaga T, Ridder BJ, Han X, Chen JE, Stockbridge NL, Wisialowski TA, Damiano B, Severi S, Morissette P, Kowey PR, Holbrook M, Smith G, Rasmusson RL, Liu M, Song Z, Qu Z, Leishman DJ, Steidl-Nichols J, Rodriguez B, Bueno-Orovio A, Zhou X, Passini E, Edwards AG, Morotti S, Ni H, Grandi E, Clancy CE, Vandenberg J, Hill A, Nakamura M, Singer T, Polonchuk L, Greiter-Wilke A, Wang K, Nave S, Fullerton A, Sobie EA, Paci M, Musuamba Tshinanu F, Strauss DG. PMID: 31709525; PMCID: PMC6977398.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    15. A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources. J Physiol. 2019 09; 597(17):4533-4564. Kernik DC, Morotti S, Wu H, Garg P, Duff HJ, Kurokawa J, Jalife J, Wu JC, Grandi E, Clancy CE. PMID: 31278749; PMCID: PMC6767694.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    16. Different paths, same destination: divergent action potential responses produce conserved cardiac fight-or-flight response in mouse and rabbit hearts. J Physiol. 2019 08; 597(15):3867-3883. Wang L, Morotti S, Tapa S, Francis Stuart SD, Jiang Y, Wang Z, Myles RC, Brack KE, Ng GA, Bers DM, Grandi E, Ripplinger CM. PMID: 31215643; PMCID: PMC6675632.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    17. Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia. J Clin Invest. 2019 06 04; 129(8):3140-3152. Syed AU, Reddy GR, Ghosh D, Prada MP, Nystoriak MA, Morotti S, Grandi E, Sirish P, Chiamvimonvat N, Hell JW, Santana LF, Xiang YK, Nieves-Cintrón M, Navedo MF. PMID: 31162142; PMCID: PMC6668679.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    18. Antiarrhythmic mechanisms of beta blocker therapy. Pharmacol Res. 2019 08; 146:104274. Grandi E, Ripplinger CM. PMID: 31100336; PMCID: PMC6679787.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    19. Enhanced Depolarization Drive in Failing Rabbit Ventricular Myocytes: Calcium-Dependent and β-Adrenergic Effects on Late Sodium, L-Type Calcium, and Sodium-Calcium Exchange Currents. Circ Arrhythm Electrophysiol. 2019 03; 12(3):e007061. Hegyi B, Morotti S, Liu C, Ginsburg KS, Bossuyt J, Belardinelli L, Izu LT, Chen-Izu Y, Bányász T, Grandi E, Bers DM. PMID: 30879336; PMCID: PMC6720130.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    20. Computational modeling: What does it tell us about atrial fibrillation therapy? Int J Cardiol. 2019 07 15; 287:155-161. Grandi E, Dobrev D, Heijman J. PMID: 30803891; PMCID: PMC6984666.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    21. Transient outward K+ current can strongly modulate action potential duration and initiate alternans in the human atrium. Am J Physiol Heart Circ Physiol. 2019 03 01; 316(3):H527-H542. Ni H, Zhang H, Grandi E, Narayan SM, Giles WR. PMID: 30576220; PMCID: PMC6415821.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    22. A Heart for Diversity: Simulating Variability in Cardiac Arrhythmia Research. Front Physiol. 2018; 9:958. Ni H, Morotti S, Grandi E. PMID: 30079031; PMCID: PMC6062641.
      View in: PubMed   Mentions: 25  
    23. Quantitative systems models illuminate arrhythmia mechanisms in heart failure: Role of the Na+ -Ca2+ -Ca2+ /calmodulin-dependent protein kinase II-reactive oxygen species feedback. Wiley Interdiscip Rev Syst Biol Med. 2019 03; 11(2):e1434. Morotti S, Grandi E. PMID: 30015404; PMCID: PMC6336536.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    24. Editorial: Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond. Front Physiol. 2018; 9:678. Grandi E, Morotti S, Pueyo E, Rodriguez B. PMID: 29937733; PMCID: PMC6003136.
      View in: PubMed   Mentions: 5  
    25. Keeping it short and (not so) simple: characterizing hERG kinetics with sinusoidal waves. J Physiol. 2018 05 15; 596(10):1783-1784. Grandi E. PMID: 29521425; PMCID: PMC5978317.
      View in: PubMed   Mentions:    Fields:    
    26. Applications of Dynamic Clamp to Cardiac Arrhythmia Research: Role in Drug Target Discovery and Safety Pharmacology Testing. Front Physiol. 2017; 8:1099. Ortega FA, Grandi E, Krogh-Madsen T, Christini DJ. PMID: 29354069; PMCID: PMC5758594.
      View in: PubMed   Mentions: 11  
    27. Inward Rectifier Potassium Channels (Kir2.x) and Caveolin-3 Domain-Specific Interaction: Implications for Purkinje Cell-Dependent Ventricular Arrhythmias. Circ Arrhythm Electrophysiol. 2018 01; 11(1):e005800. Vaidyanathan R, Van Ert H, Haq KT, Morotti S, Esch S, McCune EC, Grandi E, Eckhardt LL. PMID: 29326130; PMCID: PMC5771420.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    28. In Silico Assessment of Efficacy and Safety of IKur Inhibitors in Chronic Atrial Fibrillation: Role of Kinetics and State-Dependence of Drug Binding. Front Pharmacol. 2017; 8:799. Ellinwood N, Dobrev D, Morotti S, Grandi E. PMID: 29163179; PMCID: PMC5681918.
      View in: PubMed   Mentions: 13  
    29. Non-ion channel therapeutics for heart failure and atrial fibrillation: Are CaMKII inhibitors ready for clinical use? J Mol Cell Cardiol. 2018 08; 121:300-303. Grandi E, Dobrev D. PMID: 29079077; PMCID: PMC6358017.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    30. Recent advances in the synthesis of analogues of phytohormones strigolactones with ring-closing metathesis as a key step. Org Biomol Chem. 2017 10 04; 15(38):8218-8231. Lombardi C, Artuso E, Grandi E, Lolli M, Priola E, Prandi C. PMID: 28880031.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    31. Correction: Recent advances in the synthesis of analogues of phytohormones strigolactones with ring-closing metathesis as a key step. Org Biomol Chem. 2017 10 04; 15(38):8232. Lombardi C, Artuso E, Grandi E, Lolli M, Spyrakis F, Priola E, Prandi C. PMID: 28932861.
      View in: PubMed   Mentions:    Fields:    
    32. Erratum: "Revealing kinetics and state-dependent binding properties of IKur-targeting drugs that maximize atrial fibrillation selectivity" [Chaos 27, 093918 (2017)]. Chaos. 2017 10; 27(10):109902. Ellinwood N, Dobrev D, Morotti S, Grandi E. PMID: 29092428; PMCID: PMC6910595.
      View in: PubMed   Mentions: 3     Fields:    
    33. Revealing kinetics and state-dependent binding properties of IKur-targeting drugs that maximize atrial fibrillation selectivity. Chaos. 2017 Sep; 27(9):093918. Ellinwood N, Dobrev D, Morotti S, Grandi E. PMID: 28964116; PMCID: PMC5573366.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    34. FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility. Nat Commun. 2017 04 20; 8:15031. Surdo NC, Berrera M, Koschinski A, Brescia M, Machado MR, Carr C, Wright P, Gorelik J, Morotti S, Grandi E, Bers DM, Pantano S, Zaccolo M. PMID: 28425435; PMCID: PMC5411486.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    35. Quantitative analysis of the Ca2+ -dependent regulation of delayed rectifier K+ current IKs in rabbit ventricular myocytes. J Physiol. 2017 04 01; 595(7):2253-2268. Bartos DC, Morotti S, Ginsburg KS, Grandi E, Bers DM. PMID: 28008618; PMCID: PMC5374113.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    36. Predominant contribution of L-type Cav1.2 channel stimulation to impaired intracellular calcium and cerebral artery vasoconstriction in diabetic hyperglycemia. Channels (Austin). 2017 Jul 04; 11(4):340-346. Morotti S, Nieves-Cintrón M, Nystoriak MA, Navedo MF, Grandi E. PMID: 28631947; PMCID: PMC5555263.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    37. Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes. Sci Signal. 2017 01 24; 10(463). Nystoriak MA, Nieves-Cintrón M, Patriarchi T, Buonarati OR, Prada MP, Morotti S, Grandi E, Fernandes JD, Forbush K, Hofmann F, Sasse KC, Scott JD, Ward SM, Hell JW, Navedo MF. PMID: 28119464; PMCID: PMC5297430.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    38. Size matters, proportion too: coupling of experiments and theory reveals relative roles of K+ channels in action potential stability. J Physiol. 2017 04 01; 595(7):2319-2320. Grandi E. PMID: 28004403; PMCID: PMC5374115.
      View in: PubMed   Mentions: 1     Fields:    
    39. Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics. J Physiol. 2017 04 01; 595(7):2229-2252. Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, Bers DM, Nerbonne JM. PMID: 27808412; PMCID: PMC5374105.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimals
    40. Logistic regression analysis of populations of electrophysiological models to assess proarrythmic risk. MethodsX. 2017; 4:25-34. Morotti S, Grandi E. PMID: 28116246; PMCID: PMC5225282.
      View in: PubMed   Mentions: 26  
    41. Potassium channels in the heart: structure, function and regulation. J Physiol. 2017 04 01; 595(7):2209-2228. Grandi E, Sanguinetti MC, Bartos DC, Bers DM, Chen-Izu Y, Chiamvimonvat N, Colecraft HM, Delisle BP, Heijman J, Navedo MF, Noskov S, Proenza C, Vandenberg JI, Yarov-Yarovoy V. PMID: 27861921; PMCID: PMC5374109.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    42. Anti-arrhythmic strategies for atrial fibrillation: The role of computational modeling in discovery, development, and optimization. Pharmacol Ther. 2016 12; 168:126-142. Grandi E, Maleckar MM. PMID: 27612549; PMCID: PMC5140742.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    43. In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia. J Physiol. 2016 Feb 01; 594(3):567-93. Yang PC, Moreno JD, Miyake CY, Vaughn-Behrens SB, Jeng MT, Grandi E, Wehrens XH, Noskov SY, Clancy CE. PMID: 26515697; PMCID: PMC4784170.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    44. Slow [Na]i Changes and Positive Feedback Between Membrane Potential and [Ca]i Underlie Intermittent Early Afterdepolarizations and Arrhythmias. Circ Arrhythm Electrophysiol. 2015 Dec; 8(6):1472-80. Xie Y, Liao Z, Grandi E, Shiferaw Y, Bers DM. PMID: 26407967; PMCID: PMC4681658.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    45. Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes. J Mol Cell Cardiol. 2016 07; 96:63-71. Morotti S, McCulloch AD, Bers DM, Edwards AG, Grandi E. PMID: 26241847; PMCID: PMC4734906.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    46. Ion Channels in the Heart. Compr Physiol. 2015 Jul 01; 5(3):1423-64. Bartos DC, Grandi E, Ripplinger CM. PMID: 26140724; PMCID: PMC4516287.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimals
    47. Na+ channel function, regulation, structure, trafficking and sequestration. J Physiol. 2015 Mar 15; 593(6):1347-60. Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM. PMID: 25772290; PMCID: PMC4376415.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    48. β-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model. J Mol Cell Cardiol. 2015 Apr; 81:162-75. Negroni JA, Morotti S, Lascano EC, Gomes AV, Grandi E, Puglisi JL, Bers DM. PMID: 25724724; PMCID: PMC4380575.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    49. Nonequilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1205-13. Edwards AG, Grandi E, Hake JE, Patel S, Li P, Miyamoto S, Omens JH, Heller Brown J, Bers DM, McCulloch AD. PMID: 25236710; PMCID: PMC4301603.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    50. CaMKII comes of age in cardiac health and disease. Front Pharmacol. 2014; 5:154. Grandi E, Edwards AG, Herren AW, Bers DM. PMID: 25071573; PMCID: PMC4080132.
      View in: PubMed   Mentions: 6  
    51. CaMKII-dependent regulation of cardiac Na(+) homeostasis. Front Pharmacol. 2014; 5:41. Grandi E, Herren AW. PMID: 24653702; PMCID: PMC3948048.
      View in: PubMed   Mentions: 25  
    52. How does β-adrenergic signalling affect the transitions from ventricular tachycardia to ventricular fibrillation? Europace. 2014 Mar; 16(3):452-7. Xie Y, Grandi E, Bers DM, Sato D. PMID: 24569900; PMCID: PMC3934848.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    53. A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII. J Physiol. 2014 Mar 15; 592(6):1181-97. Morotti S, Edwards AG, McCulloch AD, Bers DM, Grandi E. PMID: 24421356; PMCID: PMC3961080.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    54. 32 Models of the Ventricular Action Potential in Health and Disease. . 2014 Jan 1; 319-330. Grandi GE, Bers BD. .
      View in: Publisher Site   Mentions:
    55. Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening. Circ Res. 2013 Sep 13; 113(7):e50-e61. Moreno JD, Yang PC, Bankston JR, Grandi E, Bers DM, Kass RS, Clancy CE. PMID: 23897695; PMCID: PMC3896218.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    56. Post-translational modifications of the cardiac Na channel: contribution of CaMKII-dependent phosphorylation to acquired arrhythmias. Am J Physiol Heart Circ Physiol. 2013 Aug 15; 305(4):H431-45. Herren AW, Bers DM, Grandi E. PMID: 23771687; PMCID: PMC3891248.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    57. β-adrenergic stimulation activates early afterdepolarizations transiently via kinetic mismatch of PKA targets. J Mol Cell Cardiol. 2013 May; 58:153-61. Xie Y, Grandi E, Puglisi JL, Sato D, Bers DM. PMID: 23481579; PMCID: PMC3628092.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    58. Theoretical study of L-type Ca(2+) current inactivation kinetics during action potential repolarization and early afterdepolarizations. J Physiol. 2012 Sep 15; 590(18):4465-81. Morotti S, Grandi E, Summa A, Ginsburg KS, Bers DM. PMID: 22586219; PMCID: PMC3477752.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    59. Altered Excitation-Contraction Coupling in Human Chronic Atrial Fibrillation. J Atr Fibrillation. 2012 Apr-May; 4(6):495. Grandi E, Workman AJ, Pandit SV. PMID: 28496736; PMCID: PMC5153202.
      View in: PubMed   Mentions: 3  
    60. Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation. Circ Res. 2011 Oct 14; 109(9):1055-66. Grandi E, Pandit SV, Voigt N, Workman AJ, Dobrev D, Jalife J, Bers DM. PMID: 21921263; PMCID: PMC3208665.
      View in: PubMed   Mentions: 164     Fields:    Translation:HumansCells
    61. Human atrial fibrillation: insights from computational electrophysiological models. Trends Cardiovasc Med. 2011 Jul; 21(5):145-50. Bers DM, Grandi E. PMID: 22732550; PMCID: PMC3384487.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    62. Late sodium current contributes to the reverse rate-dependent effect of IKr inhibition on ventricular repolarization. Circulation. 2011 Apr 26; 123(16):1713-20. Wu L, Ma J, Li H, Wang C, Grandi E, Zhang P, Luo A, Bers DM, Shryock JC, Belardinelli L. PMID: 21482963; PMCID: PMC4028960.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    63. Reactive oxygen species-activated Ca/calmodulin kinase IIδ is required for late I(Na) augmentation leading to cellular Na and Ca overload. Circ Res. 2011 Mar 04; 108(5):555-65. Wagner S, Ruff HM, Weber SL, Bellmann S, Sowa T, Schulte T, Anderson ME, Grandi E, Bers DM, Backs J, Belardinelli L, Maier LS. PMID: 21252154; PMCID: PMC3065330.
      View in: PubMed   Mentions: 148     Fields:    Translation:AnimalsCells
    64. Interplay of voltage and Ca-dependent inactivation of L-type Ca current. Prog Biophys Mol Biol. 2010 Sep; 103(1):44-50. Grandi E, Morotti S, Ginsburg KS, Severi S, Bers DM. PMID: 20184915; PMCID: PMC2907421.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    65. A novel computational model of the human ventricular action potential and Ca transient. J Mol Cell Cardiol. 2010 Jan; 48(1):112-21. Grandi E, Pasqualini FS, Bers DM. PMID: 19835882; PMCID: PMC2813400.
      View in: PubMed   Mentions: 200     Fields:    Translation:HumansAnimalsCells
    66. Calcium/calmodulin-dependent kinase II regulation of cardiac ion channels. J Cardiovasc Pharmacol. 2009 Sep; 54(3):180-7. Bers DM, Grandi E. PMID: 19333131; PMCID: PMC2784004.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    67. Ca/calmodulin kinase II differentially modulates potassium currents. Circ Arrhythm Electrophysiol. 2009 Jun; 2(3):285-94. Wagner S, Hacker E, Grandi E, Weber SL, Dybkova N, Sossalla S, Sowa T, Fabritz L, Kirchhof P, Bers DM, Maier LS. PMID: 19808479; PMCID: PMC2734104.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
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