Eleonora Grandi

Title(s)Professor, Med: Pharmacology
SchoolSchool of Medicine
AddressTupper Hall 2427
CA 95616
Phone530-752-4780
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    Collapse Research 
    Collapse Research Activities and Funding
    Development of the Predictive NeuroCardiovascular Simulator
    NIH OT2OD026580Aug 1, 2018 - Jul 31, 2022
    Role: Co-Principal Investigator
    Perturbed Sodium and Calcium Fluxes in Atrial Fibrillation
    NIH R01HL131517Jun 1, 2016 - Jul 31, 2025
    Role: Principal Investigator
    Systems Approach to understanding Excitation-Coupling and Cardiac Arrhythmias
    NIH R13HL132515Mar 2, 2016 - Feb 28, 2017
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sex Differences in Electrophysiology and Calcium Handling in Atrial Health and Fibrillation. Annu Rev Physiol. 2024 Oct 23. Smith CER, Ni H, Grandi E. PMID: 39441881.
      View in: PubMed   Mentions:    Fields:    
    2. α1C S1928 Phosphorylation of CaV1.2 Channel Controls Vascular Reactivity and Blood Pressure. J Am Heart Assoc. 2024 Oct 15; 13(20):e035375. Flores-Tamez VA, Martín-Aragón Baudel M, Hong J, Taylor JL, Ren L, Le T, Syed AU, Moustafa Y, Singhrao N, Lemus-Martinez WR, Reddy GR, Ramer V, Man KNM, Bartels P, Chen-Izu Y, Chen CY, Simo S, Dickson EJ, Morotti S, Grandi E, Santana LF, Hell JW, Horne MC, Nieves-Cintrón M, Navedo MF. PMID: 39377203.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Enhanced Ca2+-Driven Arrhythmogenic Events in Female Patients With Atrial Fibrillation: Insights From Computational Modeling. JACC Clin Electrophysiol. 2024 Sep 09. Zhang X, Wu Y, Smith CER, Louch WE, Morotti S, Dobrev D, Grandi E, Ni H. PMID: 39340505.
      View in: PubMed   Mentions:    Fields:    
    4. Modeling Idiopathic Ventricular Fibrillation Using iPSC Cardiomyocytes and Computational Approaches: A Proof-of-Concept Study. JACC Clin Electrophysiol. 2024 Sep 03. Reilly L, Josvai M, Kalluri M, Anderson CL, Ni H, Orland KM, Lang D, Glukhov AV, Grandi E, Eckhardt LL. PMID: 39297840.
      View in: PubMed   Mentions:    Fields:    
    5. Caveolar Compartmentalization of Pacemaker Signaling is Required for Stable Rhythmicity of Sinus Nodal Cells and is Disrupted in Heart Failure. bioRxiv. 2024 Aug 27. Lang D, Ni H, Medvedev RY, Liu F, Alvarez-Baron CP, Tyan L, Turner DGP, Warden A, Morotti S, Schrauth TA, Chanda B, Kamp TJ, Robertson GA, Grandi E, Glukhov AV. PMID: 38659841; PMCID: PMC11042225.
      View in: PubMed   Mentions:
    6. Enhanced Ca2+-Driven Arrhythmias in Female Patients with Atrial Fibrillation: Insights from Computational Modeling. bioRxiv. 2024 Mar 13. Zhang X, Wu Y, Smith C, Louch WE, Morotti S, Dobrev D, Grandi E, Ni H. PMID: 38496584; PMCID: PMC10942295.
      View in: PubMed   Mentions:
    7. Computational Modeling of Cardiac Electrophysiology. Methods Mol Biol. 2024; 2735:63-103. Ni H, Grandi E. PMID: 38038844.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    8. Integrative human atrial modelling unravels interactive protein kinase A and Ca2+/calmodulin-dependent protein kinase II signalling as key determinants of atrial arrhythmogenesis. Cardiovasc Res. 2023 Oct 24; 119(13):2294-2311. Ni H, Morotti S, Zhang X, Dobrev D, Grandi E. PMID: 37523735; PMCID: PMC11318383.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    9. Predictive Male-to-Female Translation of Cardiac Electrophysiological Response to Drugs. JACC Clin Electrophysiol. 2023 12; 9(12):2642-2648. Hellgren KT, Ni H, Morotti S, Grandi E. PMID: 37768254; PMCID: PMC11390274.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Enzymatic Oxy- and Amino-Functionalization in Biocatalytic Cascade Synthesis: Recent Advances and Future Perspectives. Angew Chem Int Ed Engl. 2023 11 27; 62(48):e202309012. Grandi E, Feyza Özgen F, Schmidt S, Poelarends GJ. PMID: 37639631.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    11. Dual effects of the small-conductance Ca2+-activated K+ current on human atrial electrophysiology and Ca2+-driven arrhythmogenesis: an in silico study. Am J Physiol Heart Circ Physiol. 2023 10 01; 325(4):H896-H908. Herrera NT, Zhang X, Ni H, Maleckar MM, Heijman J, Dobrev D, Grandi E, Morotti S. PMID: 37624096; PMCID: PMC10659325.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Unveiling the intricacies of intracellular Ca2+ regulation in the heart. Biophys J. 2023 08 08; 122(15):3019-3021. Smith CER, Grandi E. PMID: 37478843; PMCID: PMC10432241.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    13. Multiplatform modeling of atrial fibrillation identifies phospholamban as a central regulator of cardiac rhythm. Dis Model Mech. 2023 07 01; 16(7). Kervadec A, Kezos J, Ni H, Yu M, Marchant J, Spiering S, Kannan S, Kwon C, Andersen P, Bodmer R, Grandi E, Ocorr K, Colas AR. PMID: 37293707; PMCID: PMC10387351.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    14. Cell diversity and signalling in the cardiovascular system. J Physiol. 2023 07; 601(13):2537-2539. Grandi E. PMID: 37211722; PMCID: PMC10364990.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    15. Biocatalytic Cascade Synthesis of Enantioenriched Epoxides and Triols from Biomass-Derived Synthons Driven by Specifically Designed Enzymes. Chemistry. 2023 Jun 02; 29(31):e202300697. Grandi E, Crotti M, Sigmund MC, Xu G, Tepper PG, Poelarends GJ. PMID: 36893219.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    16. Enhanced Ca2+-Dependent SK-Channel Gating and Membrane Trafficking in Human Atrial Fibrillation. Circ Res. 2023 04 28; 132(9):e116-e133. Heijman J, Zhou X, Morotti S, Molina CE, Abu-Taha IH, Tekook M, Jespersen T, Zhang Y, Dobrev S, Milting H, Gummert J, Karck M, Kamler M, El-Armouche A, Saljic A, Grandi E, Nattel S, Dobrev D. PMID: 36927079; PMCID: PMC10147588.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    17. Diversity of cells and signals in the cardiovascular system. J Physiol. 2023 07; 601(13):2547-2592. Grandi E, Navedo MF, Saucerman JJ, Bers DM, Chiamvimonvat N, Dixon RE, Dobrev D, Gomez AM, Harraz OF, Hegyi B, Jones DK, Krogh-Madsen T, Murfee WL, Nystoriak MA, Posnack NG, Ripplinger CM, Veeraraghavan R, Weinberg S. PMID: 36744541; PMCID: PMC10313794.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    18. The funny current If is essential for the fight-or-flight response in cardiac pacemaker cells. J Gen Physiol. 2022 12 05; 154(12). Peters CH, Rickert C, Morotti S, Grandi E, Aronow KA, Beam KG, Proenza C. PMID: 36305844; PMCID: PMC9812006.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    19. Mechanisms of spontaneous Ca2+ release-mediated arrhythmia in a novel 3D human atrial myocyte model: I. Transverse-axial tubule variation. J Physiol. 2023 Jul; 601(13):2655-2683. Zhang X, Ni H, Morotti S, Smith CER, Sato D, Louch WE, Edwards AG, Grandi E. PMID: 36094888; PMCID: PMC10008525.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    20. A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene. Elife. 2022 Oct 18; 11. Ding Y, Lang D, Yan J, Bu H, Li H, Jiao K, Yang J, Ni H, Morotti S, Le T, Clark KJ, Port J, Ekker SC, Cao H, Zhang Y, Wang J, Grandi E, Li Z, Shi Y, Li Y, Glukhov AV, Xu X. PMID: 36255053; PMCID: PMC9642998.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    21. Mechanisms of spontaneous Ca2+ release-mediated arrhythmia in a novel 3D human atrial myocyte model: II. Ca2+ -handling protein variation. J Physiol. 2023 Jul; 601(13):2685-2710. Zhang X, Smith CER, Morotti S, Edwards AG, Sato D, Louch WE, Ni H, Grandi E. PMID: 36114707; PMCID: PMC10017376.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    22. Enhancing the Peroxygenase Activity of a Cofactor-Independent Peroxyzyme by Directed Evolution Enabling Gram-Scale Epoxide Synthesis. Chemistry. 2022 Oct 21; 28(59):e202201651. Sigmund MC, Xu G, Grandi E, Poelarends GJ. PMID: 35861144; PMCID: PMC9804992.
      View in: PubMed   Mentions: 1     Fields:    
    23. TGF-β1-induced endothelial-mesenchymal transition: a potential contributor to fibrotic remodeling in atrial fibrillation? J Clin Invest. 2022 07 01; 132(13). Saljic A, Grandi E, Dobrev D. PMID: 35775488; PMCID: PMC9246376.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    24. Quantitative cross-species translators of cardiac myocyte electrophysiology: Model training, experimental validation, and applications. Sci Adv. 2021 Nov 19; 7(47):eabg0927. Morotti S, Liu C, Hegyi B, Ni H, Fogli Iseppe A, Wang L, Pritoni M, Ripplinger CM, Bers DM, Edwards AG, Grandi E. PMID: 34788089; PMCID: PMC8598003.
      View in: PubMed   Mentions: 18     Fields:    
    25. Bidirectional flow of the funny current (If) during the pacemaking cycle in murine sinoatrial node myocytes. Proc Natl Acad Sci U S A. 2021 07 13; 118(28). Peters CH, Liu PW, Morotti S, Gantz SC, Grandi E, Bean BP, Proenza C. PMID: 34260402; PMCID: PMC8285948.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    26. Intracellular Na+ Modulates Pacemaking Activity in Murine Sinoatrial Node Myocytes: An In Silico Analysis. Int J Mol Sci. 2021 May 26; 22(11). Morotti S, Ni H, Peters CH, Rickert C, Asgari-Targhi A, Sato D, Glukhov AV, Proenza C, Grandi E. PMID: 34073281; PMCID: PMC8198068.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    27. Sex-Specific Classification of Drug-Induced Torsade de Pointes Susceptibility Using Cardiac Simulations and Machine Learning. Clin Pharmacol Ther. 2021 08; 110(2):380-391. Fogli Iseppe A, Ni H, Zhu S, Zhang X, Coppini R, Yang PC, Srivatsa U, Clancy CE, Edwards AG, Morotti S, Grandi E. PMID: 33772748; PMCID: PMC8316283.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    28. Computational models of cardiovascular regulatory mechanisms. J Mol Cell Cardiol. 2021 06; 155:111. McCulloch AD, Grandi E, Saucerman JJ. PMID: 33647311.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    29. Populations of in silico myocytes and tissues reveal synergy of multiatrial-predominant K+ -current block in atrial fibrillation. Br J Pharmacol. 2020 10; 177(19):4497-4515. Ni H, Fogli Iseppe A, Giles WR, Narayan SM, Zhang H, Edwards AG, Morotti S, Grandi E. PMID: 32667679; PMCID: PMC7484508.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    30. Mechanisms of Cav3-associated arrhythmia: Protein or microdomain dysfunction? Int J Cardiol. 2020 12 01; 320:97-99. Zaza A, Grandi E. PMID: 32634502; PMCID: PMC7577955.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    31. GRK5 Controls SAP97-Dependent Cardiotoxic β1 Adrenergic Receptor-CaMKII Signaling in Heart Failure. Circ Res. 2020 08 28; 127(6):796-810. Xu B, Li M, Wang Y, Zhao M, Morotti S, Shi Q, Wang Q, Barbagallo F, Teoh JP, Reddy GR, Bayne EF, Liu Y, Shen A, Puglisi JL, Ge Y, Li J, Grandi E, Nieves-Cintron M, Xiang YK. PMID: 32507058; PMCID: PMC7484403.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    32. Atrial fibrillation in a dish: insights into atrial arrhythmogenesis from induced pluripotent stem cell-derived cardiomyocytes. Cardiovasc Res. 2020 05 01; 116(6):1089-1091. Grandi E, Dobrev D. PMID: 31860074; PMCID: PMC7177502.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    33. Hypokalemia Promotes Arrhythmia by Distinct Mechanisms in Atrial and Ventricular Myocytes. Circ Res. 2020 03 27; 126(7):889-906. Tazmini K, Frisk M, Lewalle A, Laasmaa M, Morotti S, Lipsett DB, Manfra O, Skogestad J, Aronsen JM, Sejersted OM, Sjaastad I, Edwards AG, Grandi E, Niederer SA, Øie E, Louch WE. PMID: 32070187; PMCID: PMC7098435.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    34. Engineered C-N Lyase: Enantioselective Synthesis of Chiral Synthons for Artificial Dipeptide Sweeteners. Angew Chem Int Ed Engl. 2020 01 02; 59(1):429-435. Zhang J, Grandi E, Fu H, Saravanan T, Bothof L, Tepper PG, Thunnissen AWH, Poelarends GJ. PMID: 31625664; PMCID: PMC6973171.
      View in: PubMed   Mentions: 4     Fields:    
    35. General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy. Clin Pharmacol Ther. 2020 01; 107(1):102-111. Li Z, Mirams GR, Yoshinaga T, Ridder BJ, Han X, Chen JE, Stockbridge NL, Wisialowski TA, Damiano B, Severi S, Morissette P, Kowey PR, Holbrook M, Smith G, Rasmusson RL, Liu M, Song Z, Qu Z, Leishman DJ, Steidl-Nichols J, Rodriguez B, Bueno-Orovio A, Zhou X, Passini E, Edwards AG, Morotti S, Ni H, Grandi E, Clancy CE, Vandenberg J, Hill A, Nakamura M, Singer T, Polonchuk L, Greiter-Wilke A, Wang K, Nave S, Fullerton A, Sobie EA, Paci M, Musuamba Tshinanu F, Strauss DG. PMID: 31709525; PMCID: PMC6977398.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    36. A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources. J Physiol. 2019 09; 597(17):4533-4564. Kernik DC, Morotti S, Wu H, Garg P, Duff HJ, Kurokawa J, Jalife J, Wu JC, Grandi E, Clancy CE. PMID: 31278749; PMCID: PMC6767694.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    37. Different paths, same destination: divergent action potential responses produce conserved cardiac fight-or-flight response in mouse and rabbit hearts. J Physiol. 2019 08; 597(15):3867-3883. Wang L, Morotti S, Tapa S, Francis Stuart SD, Jiang Y, Wang Z, Myles RC, Brack KE, Ng GA, Bers DM, Grandi E, Ripplinger CM. PMID: 31215643; PMCID: PMC6675632.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    38. Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia. J Clin Invest. 2019 06 04; 129(8):3140-3152. Syed AU, Reddy GR, Ghosh D, Prada MP, Nystoriak MA, Morotti S, Grandi E, Sirish P, Chiamvimonvat N, Hell JW, Santana LF, Xiang YK, Nieves-Cintrón M, Navedo MF. PMID: 31162142; PMCID: PMC6668679.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    39. Antiarrhythmic mechanisms of beta blocker therapy. Pharmacol Res. 2019 08; 146:104274. Grandi E, Ripplinger CM. PMID: 31100336; PMCID: PMC6679787.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimals
    40. Enhanced Depolarization Drive in Failing Rabbit Ventricular Myocytes: Calcium-Dependent and β-Adrenergic Effects on Late Sodium, L-Type Calcium, and Sodium-Calcium Exchange Currents. Circ Arrhythm Electrophysiol. 2019 03; 12(3):e007061. Hegyi B, Morotti S, Liu C, Ginsburg KS, Bossuyt J, Belardinelli L, Izu LT, Chen-Izu Y, Bányász T, Grandi E, Bers DM. PMID: 30879336; PMCID: PMC6720130.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    41. Computational modeling: What does it tell us about atrial fibrillation therapy? Int J Cardiol. 2019 07 15; 287:155-161. Grandi E, Dobrev D, Heijman J. PMID: 30803891; PMCID: PMC6984666.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    42. Transient outward K+ current can strongly modulate action potential duration and initiate alternans in the human atrium. Am J Physiol Heart Circ Physiol. 2019 03 01; 316(3):H527-H542. Ni H, Zhang H, Grandi E, Narayan SM, Giles WR. PMID: 30576220; PMCID: PMC6415821.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    43. A Heart for Diversity: Simulating Variability in Cardiac Arrhythmia Research. Front Physiol. 2018; 9:958. Ni H, Morotti S, Grandi E. PMID: 30079031; PMCID: PMC6062641.
      View in: PubMed   Mentions: 41  
    44. Quantitative systems models illuminate arrhythmia mechanisms in heart failure: Role of the Na+ -Ca2+ -Ca2+ /calmodulin-dependent protein kinase II-reactive oxygen species feedback. Wiley Interdiscip Rev Syst Biol Med. 2019 03; 11(2):e1434. Morotti S, Grandi E. PMID: 30015404; PMCID: PMC6336536.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    45. Editorial: Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond. Front Physiol. 2018; 9:678. Grandi E, Morotti S, Pueyo E, Rodriguez B. PMID: 29937733; PMCID: PMC6003136.
      View in: PubMed   Mentions: 6  
    46. Keeping it short and (not so) simple: characterizing hERG kinetics with sinusoidal waves. J Physiol. 2018 05 15; 596(10):1783-1784. Grandi E. PMID: 29521425; PMCID: PMC5978317.
      View in: PubMed   Mentions:    Fields:    
    47. Applications of Dynamic Clamp to Cardiac Arrhythmia Research: Role in Drug Target Discovery and Safety Pharmacology Testing. Front Physiol. 2017; 8:1099. Ortega FA, Grandi E, Krogh-Madsen T, Christini DJ. PMID: 29354069; PMCID: PMC5758594.
      View in: PubMed   Mentions: 14  
    48. Inward Rectifier Potassium Channels (Kir2.x) and Caveolin-3 Domain-Specific Interaction: Implications for Purkinje Cell-Dependent Ventricular Arrhythmias. Circ Arrhythm Electrophysiol. 2018 01; 11(1):e005800. Vaidyanathan R, Van Ert H, Haq KT, Morotti S, Esch S, McCune EC, Grandi E, Eckhardt LL. PMID: 29326130; PMCID: PMC5771420.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    49. In Silico Assessment of Efficacy and Safety of IKur Inhibitors in Chronic Atrial Fibrillation: Role of Kinetics and State-Dependence of Drug Binding. Front Pharmacol. 2017; 8:799. Ellinwood N, Dobrev D, Morotti S, Grandi E. PMID: 29163179; PMCID: PMC5681918.
      View in: PubMed   Mentions: 15  
    50. Non-ion channel therapeutics for heart failure and atrial fibrillation: Are CaMKII inhibitors ready for clinical use? J Mol Cell Cardiol. 2018 08; 121:300-303. Grandi E, Dobrev D. PMID: 29079077; PMCID: PMC6358017.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    51. Correction: Recent advances in the synthesis of analogues of phytohormones strigolactones with ring-closing metathesis as a key step. Org Biomol Chem. 2017 10 04; 15(38):8232. Lombardi C, Artuso E, Grandi E, Lolli M, Spyrakis F, Priola E, Prandi C. PMID: 28932861.
      View in: PubMed   Mentions:    Fields:    
    52. Recent advances in the synthesis of analogues of phytohormones strigolactones with ring-closing metathesis as a key step. Org Biomol Chem. 2017 10 04; 15(38):8218-8231. Lombardi C, Artuso E, Grandi E, Lolli M, Priola E, Prandi C. PMID: 28880031.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    53. Erratum: "Revealing kinetics and state-dependent binding properties of IKur-targeting drugs that maximize atrial fibrillation selectivity" [Chaos 27, 093918 (2017)]. Chaos. 2017 10; 27(10):109902. Ellinwood N, Dobrev D, Morotti S, Grandi E. PMID: 29092428; PMCID: PMC6910595.
      View in: PubMed   Mentions:    Fields:    
    54. Revealing kinetics and state-dependent binding properties of IKur-targeting drugs that maximize atrial fibrillation selectivity. Chaos. 2017 Sep; 27(9):093918. Ellinwood N, Dobrev D, Morotti S, Grandi E. PMID: 28964116; PMCID: PMC5573366.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    55. FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility. Nat Commun. 2017 04 20; 8:15031. Surdo NC, Berrera M, Koschinski A, Brescia M, Machado MR, Carr C, Wright P, Gorelik J, Morotti S, Grandi E, Bers DM, Pantano S, Zaccolo M. PMID: 28425435; PMCID: PMC5411486.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    56. Quantitative analysis of the Ca2+ -dependent regulation of delayed rectifier K+ current IKs in rabbit ventricular myocytes. J Physiol. 2017 04 01; 595(7):2253-2268. Bartos DC, Morotti S, Ginsburg KS, Grandi E, Bers DM. PMID: 28008618; PMCID: PMC5374113.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    57. Predominant contribution of L-type Cav1.2 channel stimulation to impaired intracellular calcium and cerebral artery vasoconstriction in diabetic hyperglycemia. Channels (Austin). 2017 Jul 04; 11(4):340-346. Morotti S, Nieves-Cintrón M, Nystoriak MA, Navedo MF, Grandi E. PMID: 28631947; PMCID: PMC5555263.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    58. Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes. Sci Signal. 2017 01 24; 10(463). Nystoriak MA, Nieves-Cintrón M, Patriarchi T, Buonarati OR, Prada MP, Morotti S, Grandi E, Fernandes JD, Forbush K, Hofmann F, Sasse KC, Scott JD, Ward SM, Hell JW, Navedo MF. PMID: 28119464; PMCID: PMC5297430.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    59. Size matters, proportion too: coupling of experiments and theory reveals relative roles of K+ channels in action potential stability. J Physiol. 2017 04 01; 595(7):2319-2320. Grandi E. PMID: 28004403; PMCID: PMC5374115.
      View in: PubMed   Mentions: 2     Fields:    
    60. Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics. J Physiol. 2017 04 01; 595(7):2229-2252. Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, Bers DM, Nerbonne JM. PMID: 27808412; PMCID: PMC5374105.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
    61. Logistic regression analysis of populations of electrophysiological models to assess proarrythmic risk. MethodsX. 2017; 4:25-34. Morotti S, Grandi E. PMID: 28116246; PMCID: PMC5225282.
      View in: PubMed   Mentions: 36  
    62. Potassium channels in the heart: structure, function and regulation. J Physiol. 2017 04 01; 595(7):2209-2228. Grandi E, Sanguinetti MC, Bartos DC, Bers DM, Chen-Izu Y, Chiamvimonvat N, Colecraft HM, Delisle BP, Heijman J, Navedo MF, Noskov S, Proenza C, Vandenberg JI, Yarov-Yarovoy V. PMID: 27861921; PMCID: PMC5374109.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimals
    63. Anti-arrhythmic strategies for atrial fibrillation: The role of computational modeling in discovery, development, and optimization. Pharmacol Ther. 2016 12; 168:126-142. Grandi E, Maleckar MM. PMID: 27612549; PMCID: PMC5140742.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    64. In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia. J Physiol. 2016 Feb 01; 594(3):567-93. Yang PC, Moreno JD, Miyake CY, Vaughn-Behrens SB, Jeng MT, Grandi E, Wehrens XH, Noskov SY, Clancy CE. PMID: 26515697; PMCID: PMC4784170.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    65. Slow [Na]i Changes and Positive Feedback Between Membrane Potential and [Ca]i Underlie Intermittent Early Afterdepolarizations and Arrhythmias. Circ Arrhythm Electrophysiol. 2015 Dec; 8(6):1472-80. Xie Y, Liao Z, Grandi E, Shiferaw Y, Bers DM. PMID: 26407967; PMCID: PMC4681658.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    66. Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes. J Mol Cell Cardiol. 2016 07; 96:63-71. Morotti S, McCulloch AD, Bers DM, Edwards AG, Grandi E. PMID: 26241847; PMCID: PMC4734906.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    67. Ion Channels in the Heart. Compr Physiol. 2015 Jul 01; 5(3):1423-64. Bartos DC, Grandi E, Ripplinger CM. PMID: 26140724; PMCID: PMC4516287.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimals
    68. Na+ channel function, regulation, structure, trafficking and sequestration. J Physiol. 2015 Mar 15; 593(6):1347-60. Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM. PMID: 25772290; PMCID: PMC4376415.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    69. β-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model. J Mol Cell Cardiol. 2015 Apr; 81:162-75. Negroni JA, Morotti S, Lascano EC, Gomes AV, Grandi E, Puglisi JL, Bers DM. PMID: 25724724; PMCID: PMC4380575.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    70. Nonequilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1205-13. Edwards AG, Grandi E, Hake JE, Patel S, Li P, Miyamoto S, Omens JH, Heller Brown J, Bers DM, McCulloch AD. PMID: 25236710; PMCID: PMC4301603.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    71. CaMKII comes of age in cardiac health and disease. Front Pharmacol. 2014; 5:154. Grandi E, Edwards AG, Herren AW, Bers DM. PMID: 25071573; PMCID: PMC4080132.
      View in: PubMed   Mentions: 5  
    72. CaMKII-dependent regulation of cardiac Na(+) homeostasis. Front Pharmacol. 2014; 5:41. Grandi E, Herren AW. PMID: 24653702; PMCID: PMC3948048.
      View in: PubMed   Mentions: 26  
    73. How does β-adrenergic signalling affect the transitions from ventricular tachycardia to ventricular fibrillation? Europace. 2014 Mar; 16(3):452-7. Xie Y, Grandi E, Bers DM, Sato D. PMID: 24569900; PMCID: PMC3934848.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    74. A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII. J Physiol. 2014 Mar 15; 592(6):1181-97. Morotti S, Edwards AG, McCulloch AD, Bers DM, Grandi E. PMID: 24421356; PMCID: PMC3961080.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    75. 32 Models of the Ventricular Action Potential in Health and Disease. . 2014 Jan 1; 319-330. Grandi GE, Bers BD. .
      View in: Publisher Site   Mentions:
    76. Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening. Circ Res. 2013 Sep 13; 113(7):e50-e61. Moreno JD, Yang PC, Bankston JR, Grandi E, Bers DM, Kass RS, Clancy CE. PMID: 23897695; PMCID: PMC3896218.
      View in: PubMed   Mentions: 54     Fields:    Translation:Humans
    77. Post-translational modifications of the cardiac Na channel: contribution of CaMKII-dependent phosphorylation to acquired arrhythmias. Am J Physiol Heart Circ Physiol. 2013 Aug 15; 305(4):H431-45. Herren AW, Bers DM, Grandi E. PMID: 23771687; PMCID: PMC3891248.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    78. β-adrenergic stimulation activates early afterdepolarizations transiently via kinetic mismatch of PKA targets. J Mol Cell Cardiol. 2013 May; 58:153-61. Xie Y, Grandi E, Puglisi JL, Sato D, Bers DM. PMID: 23481579; PMCID: PMC3628092.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    79. Theoretical study of L-type Ca(2+) current inactivation kinetics during action potential repolarization and early afterdepolarizations. J Physiol. 2012 Sep 15; 590(18):4465-81. Morotti S, Grandi E, Summa A, Ginsburg KS, Bers DM. PMID: 22586219; PMCID: PMC3477752.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    80. Altered Excitation-Contraction Coupling in Human Chronic Atrial Fibrillation. J Atr Fibrillation. 2012 Apr-May; 4(6):495. Grandi E, Workman AJ, Pandit SV. PMID: 28496736; PMCID: PMC5153202.
      View in: PubMed   Mentions: 4  
    81. Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation. Circ Res. 2011 Oct 14; 109(9):1055-66. Grandi E, Pandit SV, Voigt N, Workman AJ, Dobrev D, Jalife J, Bers DM. PMID: 21921263; PMCID: PMC3208665.
      View in: PubMed   Mentions: 185     Fields:    Translation:HumansCells
    82. Human atrial fibrillation: insights from computational electrophysiological models. Trends Cardiovasc Med. 2011 Jul; 21(5):145-50. Bers DM, Grandi E. PMID: 22732550; PMCID: PMC3384487.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    83. Late sodium current contributes to the reverse rate-dependent effect of IKr inhibition on ventricular repolarization. Circulation. 2011 Apr 26; 123(16):1713-20. Wu L, Ma J, Li H, Wang C, Grandi E, Zhang P, Luo A, Bers DM, Shryock JC, Belardinelli L. PMID: 21482963; PMCID: PMC4028960.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    84. Reactive oxygen species-activated Ca/calmodulin kinase IIδ is required for late I(Na) augmentation leading to cellular Na and Ca overload. Circ Res. 2011 Mar 04; 108(5):555-65. Wagner S, Ruff HM, Weber SL, Bellmann S, Sowa T, Schulte T, Anderson ME, Grandi E, Bers DM, Backs J, Belardinelli L, Maier LS. PMID: 21252154; PMCID: PMC3065330.
      View in: PubMed   Mentions: 163     Fields:    Translation:AnimalsCells
    85. Interplay of voltage and Ca-dependent inactivation of L-type Ca current. Prog Biophys Mol Biol. 2010 Sep; 103(1):44-50. Grandi E, Morotti S, Ginsburg KS, Severi S, Bers DM. PMID: 20184915; PMCID: PMC2907421.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    86. A novel computational model of the human ventricular action potential and Ca transient. J Mol Cell Cardiol. 2010 Jan; 48(1):112-21. Grandi E, Pasqualini FS, Bers DM. PMID: 19835882; PMCID: PMC2813400.
      View in: PubMed   Mentions: 227     Fields:    Translation:HumansAnimalsCells
    87. Calcium/calmodulin-dependent kinase II regulation of cardiac ion channels. J Cardiovasc Pharmacol. 2009 Sep; 54(3):180-7. Bers DM, Grandi E. PMID: 19333131; PMCID: PMC2784004.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsCells
    88. Ca/calmodulin kinase II differentially modulates potassium currents. Circ Arrhythm Electrophysiol. 2009 Jun; 2(3):285-94. Wagner S, Hacker E, Grandi E, Weber SL, Dybkova N, Sossalla S, Sowa T, Fabritz L, Kirchhof P, Bers DM, Maier LS. PMID: 19808479; PMCID: PMC2734104.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    89. Theoretical investigation of action potential duration dependence on extracellular Ca2+ in human cardiomyocytes. J Mol Cell Cardiol. 2009 Mar; 46(3):332-42. Grandi E, Pasqualini FS, Pes C, Corsi C, Zaza A, Severi S. PMID: 19121322.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    90. Induction of NO synthase 2 in ventricular cardiomyocytes incubated with a conventional bicarbonate dialysis bath. Nephrol Dial Transplant. 2008 Jul; 23(7):2192-7. Grandi E, Govoni M, Furini S, Severi S, Giordano E, Santoro A, Cavalcanti S. PMID: 18281316.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    91. Patients with complex arrhythmias during and after haemodialysis suffer from different regimens of potassium removal. Nephrol Dial Transplant. 2008 Apr; 23(4):1415-21. Santoro A, Mancini E, London G, Mercadal L, Fessy H, Perrone B, Cagnoli L, Grandi E, Severi S, Cavalcanti S. PMID: 18065796.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    92. Calcium and potassium changes during haemodialysis alter ventricular repolarization duration: in vivo and in silico analysis. Nephrol Dial Transplant. 2008 Apr; 23(4):1378-86. Severi S, Grandi E, Pes C, Badiali F, Grandi F, Santoro A. PMID: 18045821.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    93. Simulation of Ca-calmodulin-dependent protein kinase II on rabbit ventricular myocyte ion currents and action potentials. Biophys J. 2007 Dec 01; 93(11):3835-47. Grandi E, Puglisi JL, Wagner S, Maier LS, Severi S, Bers DM. PMID: 17704163; PMCID: PMC2084250.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    94. In silico assessment of Y1795C and Y1795H SCN5A mutations: implication for inherited arrhythmogenic syndromes. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1):H56-65. Vecchietti S, Grandi E, Severi S, Rivolta I, Napolitano C, Priori SG, Cavalcanti S. PMID: 16980337.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    95. Cardiac response to hemodialysis with different cardiovascular tolerance: heart rate variability and QT interval analysis. Hemodial Int. 2006 Jul; 10(3):287-93. Severi S, Ciandrini A, Grandi E, Cavalcanti S, Bini S, Badiali F, Gattiani A, Cagnoli L. PMID: 16805891.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    96. Relative role of major risk factors for Type 2 diabetes development in the historical cohort of the Brisighella Heart Study: an 8-year follow-up. Diabet Med. 2005 Sep; 22(9):1263-6. Cicero AF, Dormi A, Nascetti S, Panourgia MP, Grandi E, D'Addato S, Gaddi A. PMID: 16108859.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    97. Sudden death may show a circadian time of risk depending on its anatomo-clinical causes and age. Jpn Heart J. 1993 Nov; 34(6):729-39. Gallerani M, Manfredini R, Ricci L, Cappato R, Grandi E, Dal Monte D, Cugini P, Fersini C. PMID: 8164340.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    98. [Familial arrhythmogenic dysplasia of the right ventricle. Observation of 3 cases]. G Ital Cardiol. 1986 Jan; 16(1):4-14. Zanardi F, Occari G, Cavazzini L, Grandi E, Tomasi AM. PMID: 2940142.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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