Loading...

Johannes W Hell

Title(s)Professor, Pharmacology
SchoolUniversity of California, Davis
Phone530-752-6540
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Role of a-actinin in Cav1.2 Function
    NIH/NIA R01AG055357Aug 15, 2016 - Apr 30, 2021
    Role: Principal Investigator
    Molecular Mechanisms of Postsynaptic AMPA Receptor Localization
    NIH/NIMH R01MH097887Sep 26, 2014 - Jun 30, 2019
    Role: Principal Investigator
    Signaling by cAMP within Postsynaptic Nanodomains
    NIH/NINDS R01NS078792Aug 15, 2012 - Jun 30, 2017
    Role: Principal Investigator
    Predoctoral Training in Pharmacological Sciences
    NIH/NIGMS T32GM099608Jul 1, 2012 - Jun 30, 2022
    Role: Principal Investigator
    Predoctoral Training in the Pharmacological Sciences
    NIH/NIGMS T32GM067795Jul 1, 2003 - Jun 30, 2022
    Role: Co-Principal Investigator
    The NMDA Receptor Interaction with CaMKII
    NIH/NINDS R01NS046450May 20, 2003 - Apr 30, 2008
    Role: Principal Investigator
    Subcellular Localization of Cav1.2 by a-actinin
    NIH/NIA R56AG017502Dec 1, 1999 - Aug 31, 2016
    Role: Principal Investigator
    Subcellular Localization of Cav1.2 by alpha-actinin
    NIH/NIA R01AG017502Dec 1, 1999 - Sep 30, 2013
    Role: Principal Investigator
    Postsynaptic Signaling Pathways
    NIH/NINDS R01NS035563May 1, 1997 - Jun 30, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Shen A, Chen D, Kaur M, Bartels P, Xu B, Shi Q, Martinez JM, Man KM, Nieves-Cintron M, Hell JW, Navedo MF, Yu XY, Xiang YK. ß-blockers augment L-type Ca2+ channel activity by targeting spatially restricted ß2AR signaling in neurons. Elife. 2019 Oct 14; 8. PMID: 31609201.
      View in: PubMed
    2. Man KNM, Navedo MF, Horne MC, Hell JW. ß2 Adrenergic Receptor Complexes with the L-Type Ca2+ Channel CaV1.2 and AMPA-Type Glutamate Receptors: Paradigms for Pharmacological Targeting of Protein Interactions. Annu Rev Pharmacol Toxicol. 2019 Sep 27. PMID: 31561738.
      View in: PubMed
    3. Syed AU, Reddy GR, Ghosh D, Prada MP, Nystoriak MA, Morotti S, Grandi E, Sirish P, Chiamvimonvat N, Hell JW, Santana LF, Xiang YK, Nieves-Cintrón M, Navedo MF. Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia. J Clin Invest. 2019 06 04; 129(8):3140-3152. PMID: 31162142.
      View in: PubMed
    4. Chowdhury D, Hell JW. Ca2+/Calmodulin Binding to PSD-95 Downregulates Its Palmitoylation and AMPARs in Long-Term Depression. Front Synaptic Neurosci. 2019; 11:6. PMID: 30914943.
      View in: PubMed
    5. Prada MP, Syed AU, Buonarati OR, Reddy GR, Nystoriak MA, Ghosh D, Simó S, Sato D, Sasse KC, Ward SM, Santana LF, Xiang YK, Hell JW, Nieves-Cintrón M, Navedo MF. A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia. Elife. 2019 Mar 01; 8. PMID: 30821687.
      View in: PubMed
    6. Lipsett DB, Frisk M, Aronsen JM, Nordén ES, Buonarati OR, Cataliotti A, Hell JW, Sjaastad I, Christensen G, Louch WE. Cardiomyocyte substructure reverts to an immature phenotype during heart failure. J Physiol. 2019 Apr; 597(7):1833-1853. PMID: 30707448.
      View in: PubMed
    7. Salveson I, Anderson DE, Hell JW, Ames JB. Chemical shift assignments of a calmodulin intermediate with two Ca2+ bound in complex with the IQ-motif of voltage-gated Ca2+ channels (CaV1.2). Biomol NMR Assign. 2019 04; 13(1):233-237. PMID: 30788773.
      View in: PubMed
    8. Matt L, Kim K, Chowdhury D, Hell JW. Role of Palmitoylation of Postsynaptic Proteins in Promoting Synaptic Plasticity. Front Mol Neurosci. 2019; 12:8. PMID: 30766476.
      View in: PubMed
    9. Buonarati OR, Hammes EA, Watson JF, Greger IH, Hell JW. Mechanisms of postsynaptic localization of AMPA-type glutamate receptors and their regulation during long-term potentiation. Sci Signal. 2019 Jan 01; 12(562). PMID: 30600260.
      View in: PubMed
    10. Patriarchi T, Buonarati OR, Hell JW. Postsynaptic localization and regulation of AMPA receptors and Cav1.2 by ß2 adrenergic receptor/PKA and Ca2+/CaMKII signaling. EMBO J. 2018 10 15; 37(20). PMID: 30249603.
      View in: PubMed
    11. Ghosh D, Nieves-Cintrón M, Tajada S, Brust-Mascher I, Horne MC, Hell JW, Dixon RE, Santana LF, Navedo MF. Dynamic L-type CaV1.2 channel trafficking facilitates CaV1.2 clustering and cooperative gating. Biochim Biophys Acta Mol Cell Res. 2018 09; 1865(9):1341-1355. PMID: 29959960.
      View in: PubMed
    12. Zhang L, Zhang P, Wang G, Zhang H, Zhang Y, Yu Y, Zhang M, Xiao J, Crespo P, Hell JW, Lin L, Huganir RL, Zhu JJ. Ras and Rap Signal Bidirectional Synaptic Plasticity via Distinct Subcellular Microdomains. Neuron. 2018 05 16; 98(4):783-800.e4. PMID: 29706584.
      View in: PubMed
    13. Wang J, Ishikawa M, Yang Y, Otaka M, Kim JY, Gardner GR, Stefanik MT, Milovanovic M, Huang YH, Hell JW, Wolf ME, Schlüter OM, Dong Y. Cascades of Homeostatic Dysregulation Promote Incubation of Cocaine Craving. J Neurosci. 2018 05 02; 38(18):4316-4328. PMID: 29626166.
      View in: PubMed
    14. Shen A, Nieves-Cintron M, Deng Y, Shi Q, Chowdhury D, Qi J, Hell JW, Navedo MF, Xiang YK. Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell. Nat Commun. 2018 03 13; 9(1):1050. PMID: 29535304.
      View in: PubMed
    15. Chowdhury D, Hell JW. Homeostatic synaptic scaling: molecular regulators of synaptic AMPA-type glutamate receptors. F1000Res. 2018; 7:234. PMID: 29560257.
      View in: PubMed
    16. Matt L, Kirk LM, Chenaux G, Speca DJ, Puhger KR, Pride MC, Qneibi M, Haham T, Plambeck KE, Stern-Bach Y, Silverman JL, Crawley JN, Hell JW, Díaz E. SynDIG4/Prrt1 Is Required for Excitatory Synapse Development and Plasticity Underlying Cognitive Function. Cell Rep. 2018 02 27; 22(9):2246-2253. PMID: 29490264.
      View in: PubMed
    17. Matt L, Kim K, Hergarden AC, Patriarchi T, Malik ZA, Park DK, Chowdhury D, Buonarati OR, Henderson PB, Gökçek Saraç Ç, Zhang Y, Mohapatra D, Horne MC, Ames JB, Hell JW. a-Actinin Anchors PSD-95 at Postsynaptic Sites. Neuron. 2018 03 07; 97(5):1094-1109.e9. PMID: 29429936.
      View in: PubMed
    18. Folci A, Steinberger A, Lee B, Stanika R, Scheruebel S, Campiglio M, Ramprecht C, Pelzmann B, Hell JW, Obermair GJ, Heine M, Di Biase V. Molecular mimicking of C-terminal phosphorylation tunes the surface dynamics of CaV1.2 calcium channels in hippocampal neurons. J Biol Chem. 2018 01 19; 293(3):1040-1053. PMID: 29180451.
      View in: PubMed
    19. Sacktor TC, Hell JW. The genetics of PKM? and memory maintenance. Sci Signal. 2017 Nov 14; 10(505). PMID: 29138296.
      View in: PubMed
    20. Chowdhury D, Turner M, Patriarchi T, Hergarden AC, Anderson D, Zhang Y, Sun J, Chen CY, Ames JB, Hell JW. Ca2+/calmodulin binding to PSD-95 mediates homeostatic synaptic scaling down. EMBO J. 2018 01 04; 37(1):122-138. PMID: 29118000.
      View in: PubMed
    21. Nieves-Cintrón M, Syed AU, Buonarati OR, Rigor RR, Nystoriak MA, Ghosh D, Sasse KC, Ward SM, Santana LF, Hell JW, Navedo MF. Impaired BKCa channel function in native vascular smooth muscle from humans with type 2 diabetes. Sci Rep. 2017 10 25; 7(1):14058. PMID: 29070899.
      View in: PubMed
    22. Buonarati OR, Henderson PB, Murphy GG, Horne MC, Hell JW. Proteolytic processing of the L-type Ca 2+ channel alpha 11.2 subunit in neurons. F1000Res. 2017; 6:1166. PMID: 28781760.
      View in: PubMed
    23. Tseng PY, Henderson PB, Hergarden AC, Patriarchi T, Coleman AM, Lillya MW, Montagut-Bordas C, Lee B, Hell JW, Horne MC. a-Actinin Promotes Surface Localization and Current Density of the Ca2+ Channel CaV1.2 by Binding to the IQ Region of the a1 Subunit. Biochemistry. 2017 07 18; 56(28):3669-3681. PMID: 28613835.
      View in: PubMed
    24. Goodell DJ, Zaegel V, Coultrap SJ, Hell JW, Bayer KU. DAPK1 Mediates LTD by Making CaMKII/GluN2B Binding LTP Specific. Cell Rep. 2017 06 13; 19(11):2231-2243. PMID: 28614711.
      View in: PubMed
    25. Horne MC, Hell JW. Angiotensin II signalling kicks out p27Kip1 : casein kinase 2 augmentation of Cav 1.2 L-type Ca2+ channel activity in immature ventricular cardiomyocytes. J Physiol. 2017 07 01; 595(13):4131-4132. PMID: 28488737.
      View in: PubMed
    26. Schampel A, Volovitch O, Koeniger T, Scholz CJ, Jörg S, Linker RA, Wischmeyer E, Wunsch M, Hell JW, Ergün S, Kuerten S. Nimodipine fosters remyelination in a mouse model of multiple sclerosis and induces microglia-specific apoptosis. Proc Natl Acad Sci U S A. 2017 04 18; 114(16):E3295-E3304. PMID: 28381594.
      View in: PubMed
    27. Qian H, Patriarchi T, Price JL, Matt L, Lee B, Nieves-Cintrón M, Buonarati OR, Chowdhury D, Nanou E, Nystoriak MA, Catterall WA, Poomvanicha M, Hofmann F, Navedo MF, Hell JW. Phosphorylation of Ser1928 mediates the enhanced activity of the L-type Ca2+ channel Cav1.2 by the ß2-adrenergic receptor in neurons. Sci Signal. 2017 01 24; 10(463). PMID: 28119465.
      View in: PubMed
    28. Hell JW, Navedo MF, VanHook AM. Science Signaling Podcast for 24 January 2017: Tissue-specific regulation of L-type calcium channels. Sci Signal. 2017 01 24; 10(463). PMID: 28119457.
      View in: PubMed
    29. Nystoriak MA, Nieves-Cintrón M, Patriarchi T, Buonarati OR, Prada MP, Morotti S, Grandi E, Fernandes JD, Forbush K, Hofmann F, Sasse KC, Scott JD, Ward SM, Hell JW, Navedo MF. Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes. Sci Signal. 2017 01 24; 10(463). PMID: 28119464.
      View in: PubMed
    30. Chenaux G, Matt L, Hill TC, Kaur I, Liu XB, Kirk LM, Speca DJ, McMahon SA, Zito K, Hell JW, Díaz E. Loss of SynDIG1 Reduces Excitatory Synapse Maturation But Not Formation In Vivo. eNeuro. 2016 Sep-Oct; 3(5). PMID: 27800545.
      View in: PubMed
    31. Barcomb K, Hell JW, Benke TA, Bayer KU. The CaMKII/GluN2B Protein Interaction Maintains Synaptic Strength. J Biol Chem. 2016 07 29; 291(31):16082-9. PMID: 27246855.
      View in: PubMed
    32. Gray JA, Zito K, Hell JW. Non-ionotropic signaling by the NMDA receptor: controversy and opportunity. F1000Res. 2016; 5. PMID: 27303637.
      View in: PubMed
    33. Hell JW. How Ca2+-permeable AMPA receptors, the kinase PKA, and the phosphatase PP2B are intertwined in synaptic LTP and LTD. Sci Signal. 2016 04 26; 9(425):e2. PMID: 27117250.
      View in: PubMed
    34. Patriarchi T, Qian H, Di Biase V, Malik ZA, Chowdhury D, Price JL, Hammes EA, Buonarati OR, Westenbroek RE, Catterall WA, Hofmann F, Xiang YK, Murphy GG, Chen CY, Navedo MF, Hell JW. Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the ß2 adrenergic receptor. EMBO J. 2016 06 15; 35(12):1330-45. PMID: 27103070.
      View in: PubMed
    35. Turner M, Anderson DE, Rajan S, Hell JW, Ames JB. Chemical shift assignments of the C-terminal EF-hand domain of a-actinin-1. Biomol NMR Assign. 2016 Apr; 10(1):219-22. PMID: 26861220.
      View in: PubMed
    36. He K, Huertas M, Hong SZ, Tie X, Hell JW, Shouval H, Kirkwood A. Distinct Eligibility Traces for LTP and LTD in Cortical Synapses. Neuron. 2015 Nov 04; 88(3):528-38. PMID: 26593091.
      View in: PubMed
    37. Patriarchi T, Amabile S, Frullanti E, Landucci E, Lo Rizzo C, Ariani F, Costa M, Olimpico F, W Hell J, M Vaccarino F, Renieri A, Meloni I. Imbalance of excitatory/inhibitory synaptic protein expression in iPSC-derived neurons from FOXG1(+/-) patients and in foxg1(+/-) mice. Eur J Hum Genet. 2016 06; 24(6):871-80. PMID: 26443267.
      View in: PubMed
    38. Atkin G, Moore S, Lu Y, Nelson RF, Tipper N, Rajpal G, Hunt J, Tennant W, Hell JW, Murphy GG, Paulson H. Loss of F-box only protein 2 (Fbxo2) disrupts levels and localization of select NMDA receptor subunits, and promotes aberrant synaptic connectivity. J Neurosci. 2015 Apr 15; 35(15):6165-78. PMID: 25878288.
      View in: PubMed
    39. Malik ZA, Stein IS, Navedo MF, Hell JW. Mission CaMKII?: shuttle calmodulin from membrane to nucleus. Cell. 2014 Oct 09; 159(2):235-7. PMID: 25303520.
      View in: PubMed
    40. Chen CY, Matt L, Hell JW, Rogawski MA. Perampanel inhibition of AMPA receptor currents in cultured hippocampal neurons. PLoS One. 2014; 9(9):e108021. PMID: 25229608.
      View in: PubMed
    41. Stein IS, Donaldson MS, Hell JW. CaMKII binding to GluN2B is important for massed spatial learning in the Morris water maze. F1000Res. 2014; 3:193. PMID: 25187880.
      View in: PubMed
    42. Navedo MF, Hell JW. AKAP5 keeps L-type channels and NFAT on their toes. Cell Rep. 2014 Jun 12; 7(5):1341-1342. PMID: 24926793.
      View in: PubMed
    43. Livide G, Patriarchi T, Amenduni M, Amabile S, Yasui D, Calcagno E, Lo Rizzo C, De Falco G, Ulivieri C, Ariani F, Mari F, Mencarelli MA, Hell JW, Renieri A, Meloni I. GluD1 is a common altered player in neuronal differentiation from both MECP2-mutated and CDKL5-mutated iPS cells. Eur J Hum Genet. 2015 Feb; 23(2):195-201. PMID: 24916645.
      View in: PubMed
    44. Zhang Y, Matt L, Patriarchi T, Malik ZA, Chowdhury D, Park DK, Renieri A, Ames JB, Hell JW. Capping of the N-terminus of PSD-95 by calmodulin triggers its postsynaptic release. EMBO J. 2014 Jun 17; 33(12):1341-53. PMID: 24705785.
      View in: PubMed
    45. Speca DJ, Ogata G, Mandikian D, Bishop HI, Wiler SW, Eum K, Wenzel HJ, Doisy ET, Matt L, Campi KL, Golub MS, Nerbonne JM, Hell JW, Trainor BC, Sack JT, Schwartzkroin PA, Trimmer JS. Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability. Genes Brain Behav. 2014 Apr; 13(4):394-408. PMID: 24494598.
      View in: PubMed
    46. Matt L, Hell JW. LTP: GluN2B on the go. EMBO J. 2014 Apr 16; 33(8):781-2. PMID: 24599308.
      View in: PubMed
    47. Hell JW. CaMKII: claiming center stage in postsynaptic function and organization. Neuron. 2014 Jan 22; 81(2):249-65. PMID: 24462093.
      View in: PubMed
    48. Murphy JA, Stein IS, Lau CG, Peixoto RT, Aman TK, Kaneko N, Aromolaran K, Saulnier JL, Popescu GK, Sabatini BL, Hell JW, Zukin RS. Phosphorylation of Ser1166 on GluN2B by PKA is critical to synaptic NMDA receptor function and Ca2+ signaling in spines. J Neurosci. 2014 Jan 15; 34(3):869-79. PMID: 24431445.
      View in: PubMed
    49. Núñez-Santana FL, Oh MM, Antion MD, Lee A, Hell JW, Disterhoft JF. Surface L-type Ca2+ channel expression levels are increased in aged hippocampus. Aging Cell. 2014 Feb; 13(1):111-20. PMID: 24033980.
      View in: PubMed
    50. Zuccotti A, Lee SC, Campanelli D, Singer W, Satheesh SV, Patriarchi T, Geisler HS, Köpschall I, Rohbock K, Nothwang HG, Hu J, Hell JW, Schimmang T, Rüttiger L, Knipper M. L-type CaV1.2 deletion in the cochlea but not in the brainstem reduces noise vulnerability: implication for CaV1.2-mediated control of cochlear BDNF expression. Front Mol Neurosci. 2013; 6:20. PMID: 23950737.
      View in: PubMed
    51. Hall DD, Dai S, Tseng PY, Malik Z, Nguyen M, Matt L, Schnizler K, Shephard A, Mohapatra DP, Tsuruta F, Dolmetsch RE, Christel CJ, Lee A, Burette A, Weinberg RJ, Hell JW. Competition between a-actinin and Ca²?-calmodulin controls surface retention of the L-type Ca²? channel Ca(V)1.2. Neuron. 2013 May 08; 78(3):483-97. PMID: 23664615.
      View in: PubMed
    52. Zhang M, Patriarchi T, Stein IS, Qian H, Matt L, Nguyen M, Xiang YK, Hell JW. Adenylyl cyclase anchoring by a kinase anchor protein AKAP5 (AKAP79/150) is important for postsynaptic ß-adrenergic signaling. J Biol Chem. 2013 Jun 14; 288(24):17918-31. PMID: 23649627.
      View in: PubMed
    53. Matt L, Hell JW. PKC?: a new player in LTP coming to the rescue of PKC?'s faltering role in LTP? EMBO J. 2013 May 15; 32(10):1348-9. PMID: 23563118.
      View in: PubMed
    54. Wang D, Fu Q, Zhou Y, Xu B, Shi Q, Igwe B, Matt L, Hell JW, Wisely EV, Oddo S, Xiang YK. ß2 adrenergic receptor, protein kinase A (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in Alzheimer disease models. J Biol Chem. 2013 Apr 12; 288(15):10298-307. PMID: 23430246.
      View in: PubMed
    55. Harvey RD, Hell JW. CaV1.2 signaling complexes in the heart. J Mol Cell Cardiol. 2013 May; 58:143-52. PMID: 23266596.
      View in: PubMed
    56. Hamilton AM, Oh WC, Vega-Ramirez H, Stein IS, Hell JW, Patrick GN, Zito K. Activity-dependent growth of new dendritic spines is regulated by the proteasome. Neuron. 2012 Jun 21; 74(6):1023-30. PMID: 22726833.
      View in: PubMed
    57. Xu J, Kurup P, Bartos JA, Patriarchi T, Hell JW, Lombroso PJ. Striatal-enriched protein-tyrosine phosphatase (STEP) regulates Pyk2 kinase activity. J Biol Chem. 2012 Jun 15; 287(25):20942-56. PMID: 22544749.
      View in: PubMed
    58. Qian H, Matt L, Zhang M, Nguyen M, Patriarchi T, Koval OM, Anderson ME, He K, Lee HK, Hell JW. ß2-Adrenergic receptor supports prolonged theta tetanus-induced LTP. J Neurophysiol. 2012 May; 107(10):2703-12. PMID: 22338020.
      View in: PubMed
    59. Halt AR, Dallapiazza RF, Zhou Y, Stein IS, Qian H, Juntti S, Wojcik S, Brose N, Silva AJ, Hell JW. CaMKII binding to GluN2B is critical during memory consolidation. EMBO J. 2012 Mar 07; 31(5):1203-16. PMID: 22234183.
      View in: PubMed
    60. Evans TI, Hell JW, Shea MA. Thermodynamic linkage between calmodulin domains binding calcium and contiguous sites in the C-terminal tail of Ca(V)1.2. Biophys Chem. 2011 Nov; 159(1):172-87. PMID: 21757287.
      View in: PubMed
    61. Sanhueza M, Fernandez-Villalobos G, Stein IS, Kasumova G, Zhang P, Bayer KU, Otmakhov N, Hell JW, Lisman J. Role of the CaMKII/NMDA receptor complex in the maintenance of synaptic strength. J Neurosci. 2011 Jun 22; 31(25):9170-8. PMID: 21697368.
      View in: PubMed
    62. Lu Y, Zha XM, Kim EY, Schachtele S, Dailey ME, Hall DD, Strack S, Green SH, Hoffman DA, Hell JW. A kinase anchor protein 150 (AKAP150)-associated protein kinase A limits dendritic spine density. J Biol Chem. 2011 Jul 29; 286(30):26496-506. PMID: 21652711.
      View in: PubMed
    63. Xu H, Ginsburg KS, Hall DD, Zimmermann M, Stein IS, Zhang M, Tandan S, Hill JA, Horne MC, Bers D, Hell JW. Targeting of protein phosphatases PP2A and PP2B to the C-terminus of the L-type calcium channel Ca v1.2. Biochemistry. 2010 Dec 07; 49(48):10298-307. PMID: 21053940.
      View in: PubMed
    64. Hell JW. Beta-adrenergic regulation of the L-type Ca2+ channel Ca(V)1.2 by PKA rekindles excitement. Sci Signal. 2010 Sep 28; 3(141):pe33. PMID: 20876870.
      View in: PubMed
    65. Stein IS, Hell JW. CaMKII hunkers down on the muscarinic M4 receptor to help curb cocaine-induced hyperlocomotion. EMBO J. 2010 Jun 16; 29(12):1943-5. PMID: 20551968.
      View in: PubMed
    66. Weisenhaus M, Allen ML, Yang L, Lu Y, Nichols CB, Su T, Hell JW, McKnight GS. Mutations in AKAP5 disrupt dendritic signaling complexes and lead to electrophysiological and behavioral phenotypes in mice. PLoS One. 2010 Apr 23; 5(4):e10325. PMID: 20428246.
      View in: PubMed
    67. Bartos JA, Ulrich JD, Li H, Beazely MA, Chen Y, Macdonald JF, Hell JW. Postsynaptic clustering and activation of Pyk2 by PSD-95. J Neurosci. 2010 Jan 13; 30(2):449-63. PMID: 20071509.
      View in: PubMed
    68. Joiner ML, Lisé MF, Yuen EY, Kam AY, Zhang M, Hall DD, Malik ZA, Qian H, Chen Y, Ulrich JD, Burette AC, Weinberg RJ, Law PY, El-Husseini A, Yan Z, Hell JW. Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling. EMBO J. 2010 Jan 20; 29(2):482-95. PMID: 19942860.
      View in: PubMed
    69. van Gemert NG, Carvalho DM, Karst H, van der Laan S, Zhang M, Meijer OC, Hell JW, Joëls M. Dissociation between rat hippocampal CA1 and dentate gyrus cells in their response to corticosterone: effects on calcium channel protein and current. Endocrinology. 2009 Oct; 150(10):4615-24. PMID: 19589863.
      View in: PubMed
    70. Tandan S, Wang Y, Wang TT, Jiang N, Hall DD, Hell JW, Luo X, Rothermel BA, Hill JA. Physical and functional interaction between calcineurin and the cardiac L-type Ca2+ channel. Circ Res. 2009 Jul 02; 105(1):51-60. PMID: 19478199.
      View in: PubMed
    71. Dai S, Hall DD, Hell JW. Supramolecular assemblies and localized regulation of voltage-gated ion channels. Physiol Rev. 2009 Apr; 89(2):411-52. PMID: 19342611.
      View in: PubMed
    72. Hell JW. Hooked on the D3 receptor: CaMKII's new addiction. Neuron. 2009 Feb 12; 61(3):335-6. PMID: 19217370.
      View in: PubMed
    73. Schnizler MK, Schnizler K, Zha XM, Hall DD, Wemmie JA, Hell JW, Welsh MJ. The cytoskeletal protein alpha-actinin regulates acid-sensing ion channel 1a through a C-terminal interaction. J Biol Chem. 2009 Jan 30; 284(5):2697-705. PMID: 19028690.
      View in: PubMed
    74. Dagda RK, Merrill RA, Cribbs JT, Chen Y, Hell JW, Usachev YM, Strack S. The spinocerebellar ataxia 12 gene product and protein phosphatase 2A regulatory subunit Bbeta2 antagonizes neuronal survival by promoting mitochondrial fission. J Biol Chem. 2008 Dec 26; 283(52):36241-8. PMID: 18940801.
      View in: PubMed
    75. Lu Y, Zhang M, Lim IA, Hall DD, Allen M, Medvedeva Y, McKnight GS, Usachev YM, Hell JW. AKAP150-anchored PKA activity is important for LTD during its induction phase. J Physiol. 2008 Sep 01; 586(17):4155-64. PMID: 18617570.
      View in: PubMed
    76. Schnizler K, Shutov LP, Van Kanegan MJ, Merrill MA, Nichols B, McKnight GS, Strack S, Hell JW, Usachev YM. Protein kinase A anchoring via AKAP150 is essential for TRPV1 modulation by forskolin and prostaglandin E2 in mouse sensory neurons. J Neurosci. 2008 May 07; 28(19):4904-17. PMID: 18463244.
      View in: PubMed
    77. Chen Y, Stevens B, Chang J, Milbrandt J, Barres BA, Hell JW. NS21: re-defined and modified supplement B27 for neuronal cultures. J Neurosci Methods. 2008 Jun 30; 171(2):239-47. PMID: 18471889.
      View in: PubMed
    78. Kaduce TL, Chen Y, Hell JW, Spector AA. Docosahexaenoic acid synthesis from n-3 fatty acid precursors in rat hippocampal neurons. J Neurochem. 2008 May; 105(4):1525-35. PMID: 18248613.
      View in: PubMed
    79. Zhou Y, Takahashi E, Li W, Halt A, Wiltgen B, Ehninger D, Li GD, Hell JW, Kennedy MB, Silva AJ. Interactions between the NR2B receptor and CaMKII modulate synaptic plasticity and spatial learning. J Neurosci. 2007 Dec 12; 27(50):13843-53. PMID: 18077696.
      View in: PubMed
    80. Ataman ZA, Gakhar L, Sorensen BR, Hell JW, Shea MA. The NMDA receptor NR1 C1 region bound to calmodulin: structural insights into functional differences between homologous domains. Structure. 2007 Dec; 15(12):1603-17. PMID: 18073110.
      View in: PubMed
    81. Lu Y, Allen M, Halt AR, Weisenhaus M, Dallapiazza RF, Hall DD, Usachev YM, McKnight GS, Hell JW. Age-dependent requirement of AKAP150-anchored PKA and GluR2-lacking AMPA receptors in LTP. EMBO J. 2007 Nov 28; 26(23):4879-90. PMID: 17972919.
      View in: PubMed
    82. Merrill MA, Malik Z, Akyol Z, Bartos JA, Leonard AS, Hudmon A, Shea MA, Hell JW. Displacement of alpha-actinin from the NMDA receptor NR1 C0 domain By Ca2+/calmodulin promotes CaMKII binding. Biochemistry. 2007 Jul 24; 46(29):8485-97. PMID: 17602661.
      View in: PubMed
    83. Hall DD, Davare MA, Shi M, Allen ML, Weisenhaus M, McKnight GS, Hell JW. Critical role of cAMP-dependent protein kinase anchoring to the L-type calcium channel Cav1.2 via A-kinase anchor protein 150 in neurons. Biochemistry. 2007 Feb 13; 46(6):1635-46. PMID: 17279627.
      View in: PubMed
    84. Murphy GG, Shah V, Hell JW, Silva AJ. Investigation of age-related cognitive decline using mice as a model system: neurophysiological correlates. Am J Geriatr Psychiatry. 2006 Dec; 14(12):1012-21. PMID: 17138808.
      View in: PubMed
    85. Li J, Marionneau C, Zhang R, Shah V, Hell JW, Nerbonne JM, Anderson ME. Calmodulin kinase II inhibition shortens action potential duration by upregulation of K+ currents. Circ Res. 2006 Nov 10; 99(10):1092-9. PMID: 17038644.
      View in: PubMed
    86. Balijepalli RC, Foell JD, Hall DD, Hell JW, Kamp TJ. Localization of cardiac L-type Ca(2+) channels to a caveolar macromolecular signaling complex is required for beta(2)-adrenergic regulation. Proc Natl Acad Sci U S A. 2006 May 09; 103(19):7500-5. PMID: 16648270.
      View in: PubMed
    87. Hall DD, Feekes JA, Arachchige Don AS, Shi M, Hamid J, Chen L, Strack S, Zamponi GW, Horne MC, Hell JW. Binding of protein phosphatase 2A to the L-type calcium channel Cav1.2 next to Ser1928, its main PKA site, is critical for Ser1928 dephosphorylation. Biochemistry. 2006 Mar 14; 45(10):3448-59. PMID: 16519540.
      View in: PubMed
    88. Merrill MA, Chen Y, Strack S, Hell JW. Activity-driven postsynaptic translocation of CaMKII. Trends Pharmacol Sci. 2005 Dec; 26(12):645-53. PMID: 16253351.
      View in: PubMed
    89. Christopherson KS, Ullian EM, Stokes CC, Mullowney CE, Hell JW, Agah A, Lawler J, Mosher DF, Bornstein P, Barres BA. Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis. Cell. 2005 Feb 11; 120(3):421-33. PMID: 15707899.
      View in: PubMed
    90. Cohen RM, Foell JD, Balijepalli RC, Shah V, Hell JW, Kamp TJ. Unique modulation of L-type Ca2+ channels by short auxiliary beta1d subunit present in cardiac muscle. Am J Physiol Heart Circ Physiol. 2005 May; 288(5):H2363-74. PMID: 15615847.
      View in: PubMed
    91. Davare MA, Hell JW. Increased phosphorylation of the neuronal L-type Ca(2+) channel Ca(v)1.2 during aging. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):16018-23. PMID: 14665691.
      View in: PubMed
    92. Lim IA, Merrill MA, Chen Y, Hell JW. Disruption of the NMDA receptor-PSD-95 interaction in hippocampal neurons with no obvious physiological short-term effect. Neuropharmacology. 2003 Nov; 45(6):738-54. PMID: 14529713.
      View in: PubMed
    93. Akyol Z, Bartos JA, Merrill MA, Faga LA, Jaren OR, Shea MA, Hell JW. Apo-calmodulin binds with its C-terminal domain to the N-methyl-D-aspartate receptor NR1 C0 region. J Biol Chem. 2004 Jan 16; 279(3):2166-75. PMID: 14530275.
      View in: PubMed
    94. Seabold GK, Burette A, Lim IA, Weinberg RJ, Hell JW. Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 and SAP102. J Biol Chem. 2003 Apr 25; 278(17):15040-8. PMID: 12576483.
      View in: PubMed
    95. Cottom J, Salvador LM, Maizels ET, Reierstad S, Park Y, Carr DW, Davare MA, Hell JW, Palmer SS, Dent P, Kawakatsu H, Ogata M, Hunzicker-Dunn M. Follicle-stimulating hormone activates extracellular signal-regulated kinase but not extracellular signal-regulated kinase kinase through a 100-kDa phosphotyrosine phosphatase. J Biol Chem. 2003 Feb 28; 278(9):7167-79. PMID: 12493768.
      View in: PubMed
    96. Leonard AS, Bayer KU, Merrill MA, Lim IA, Shea MA, Schulman H, Hell JW. Regulation of calcium/calmodulin-dependent protein kinase II docking to N-methyl-D-aspartate receptors by calcium/calmodulin and alpha-actinin. J Biol Chem. 2002 Dec 13; 277(50):48441-8. PMID: 12379661.
      View in: PubMed
    97. Tavalin SJ, Colledge M, Hell JW, Langeberg LK, Huganir RL, Scott JD. Regulation of GluR1 by the A-kinase anchoring protein 79 (AKAP79) signaling complex shares properties with long-term depression. J Neurosci. 2002 Apr 15; 22(8):3044-51. PMID: 11943807.
      View in: PubMed
    98. Lim IA, Hall DD, Hell JW. Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102. J Biol Chem. 2002 Jun 14; 277(24):21697-711. PMID: 11937501.
      View in: PubMed
    99. Karpen JW, Rich TC. The fourth dimension in cellular signaling. Science. 2001 Sep 21; 293(5538):2204-5. PMID: 11569497.
      View in: PubMed
    100. Davare MA, Avdonin V, Hall DD, Peden EM, Burette A, Weinberg RJ, Horne MC, Hoshi T, Hell JW. A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2. Science. 2001 Jul 06; 293(5527):98-101. PMID: 11441182.
      View in: PubMed
    101. Bayer KU, De Koninck P, Leonard AS, Hell JW, Schulman H. Interaction with the NMDA receptor locks CaMKII in an active conformation. Nature. 2001 Jun 14; 411(6839):801-5. PMID: 11459059.
      View in: PubMed
    102. Davare MA, Horne MC, Hell JW. Protein phosphatase 2A is associated with class C L-type calcium channels (Cav1.2) and antagonizes channel phosphorylation by cAMP-dependent protein kinase. J Biol Chem. 2000 Dec 15; 275(50):39710-7. PMID: 10984483.
      View in: PubMed
    103. Kamp TJ, Hell JW. Regulation of cardiac L-type calcium channels by protein kinase A and protein kinase C. Circ Res. 2000 Dec 08; 87(12):1095-102. PMID: 11110765.
      View in: PubMed
    104. Valtschanoff JG, Burette A, Davare MA, Leonard AS, Hell JW, Weinberg RJ. SAP97 concentrates at the postsynaptic density in cerebral cortex. Eur J Neurosci. 2000 Oct; 12(10):3605-14. PMID: 11029631.
      View in: PubMed
    105. Sans N, Petralia RS, Wang YX, Blahos J, Hell JW, Wenthold RJ. A developmental change in NMDA receptor-associated proteins at hippocampal synapses. J Neurosci. 2000 Feb 01; 20(3):1260-71. PMID: 10648730.
      View in: PubMed
    106. Davare MA, Dong F, Rubin CS, Hell JW. The A-kinase anchor protein MAP2B and cAMP-dependent protein kinase are associated with class C L-type calcium channels in neurons. J Biol Chem. 1999 Oct 15; 274(42):30280-7. PMID: 10514522.
      View in: PubMed
    107. Leonard AS, Lim IA, Hemsworth DE, Horne MC, Hell JW. Calcium/calmodulin-dependent protein kinase II is associated with the N-methyl-D-aspartate receptor. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):3239-44. PMID: 10077668.
      View in: PubMed
    108. Leonard AS, Davare MA, Horne MC, Garner CC, Hell JW. SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit. J Biol Chem. 1998 Jul 31; 273(31):19518-24. PMID: 9677374.
      View in: PubMed
    109. Hell JW, Jahn R. Bioenergetic characterization of gamma-aminobutyric acid transporter of synaptic vesicles. Methods Enzymol. 1998; 296:116-24. PMID: 9779444.
      View in: PubMed
    110. Hell JW. Phosphorylation of receptors and ion channels and their interaction with structural proteins. Neurochem Int. 1997 Nov; 31(5):651-8. PMID: 9364451.
      View in: PubMed
    111. Horne MC, Donaldson KL, Goolsby GL, Tran D, Mulheisen M, Hell JW, Wahl AF. Cyclin G2 is up-regulated during growth inhibition and B cell antigen receptor-mediated cell cycle arrest. J Biol Chem. 1997 May 09; 272(19):12650-61. PMID: 9139721.
      View in: PubMed
    112. Leonard AS, Hell JW. Cyclic AMP-dependent protein kinase and protein kinase C phosphorylate N-methyl-D-aspartate receptors at different sites. J Biol Chem. 1997 May 02; 272(18):12107-15. PMID: 9115280.
      View in: PubMed
    113. De Jongh KS, Murphy BJ, Colvin AA, Hell JW, Takahashi M, Catterall WA. Specific phosphorylation of a site in the full-length form of the alpha 1 subunit of the cardiac L-type calcium channel by adenosine 3',5'-cyclic monophosphate-dependent protein kinase. Biochemistry. 1996 Aug 13; 35(32):10392-402. PMID: 8756695.
      View in: PubMed
    114. Sakurai T, Westenbroek RE, Rettig J, Hell J, Catterall WA. Biochemical properties and subcellular distribution of the BI and rbA isoforms of alpha 1A subunits of brain calcium channels. J Cell Biol. 1996 Jul; 134(2):511-28. PMID: 8707834.
      View in: PubMed
    115. Hell JW, Westenbroek RE, Breeze LJ, Wang KK, Chavkin C, Catterall WA. N-methyl-D-aspartate receptor-induced proteolytic conversion of postsynaptic class C L-type calcium channels in hippocampal neurons. Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8):3362-7. PMID: 8622942.
      View in: PubMed
    116. Yokoyama CT, Westenbroek RE, Hell JW, Soong TW, Snutch TP, Catterall WA. Biochemical properties and subcellular distribution of the neuronal class E calcium channel alpha 1 subunit. J Neurosci. 1995 Oct; 15(10):6419-32. PMID: 7472405.
      View in: PubMed
    117. Westenbroek RE, Sakurai T, Elliott EM, Hell JW, Starr TV, Snutch TP, Catterall WA. Immunochemical identification and subcellular distribution of the alpha 1A subunits of brain calcium channels. J Neurosci. 1995 Oct; 15(10):6403-18. PMID: 7472404.
      View in: PubMed
    118. Sakurai T, Hell JW, Woppmann A, Miljanich GP, Catterall WA. Immunochemical identification and differential phosphorylation of alternatively spliced forms of the alpha 1A subunit of brain calcium channels. J Biol Chem. 1995 Sep 08; 270(36):21234-42. PMID: 7673157.
      View in: PubMed
    119. Hell JW, Yokoyama CT, Breeze LJ, Chavkin C, Catterall WA. Phosphorylation of presynaptic and postsynaptic calcium channels by cAMP-dependent protein kinase in hippocampal neurons. EMBO J. 1995 Jul 03; 14(13):3036-44. PMID: 7621818.
      View in: PubMed
    120. Hell JW, Westenbroek RE, Elliott EM, Catterall WA. Differential phosphorylation, localization, and function of distinct alpha 1 subunits of neuronal calcium channels. Two size forms for class B, C, and D alpha 1 subunits with different COOH-termini. Ann N Y Acad Sci. 1994 Dec 15; 747:282-93. PMID: 7847677.
      View in: PubMed
    121. Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA. Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini. J Biol Chem. 1994 Mar 11; 269(10):7390-6. PMID: 8125957.
      View in: PubMed
    122. Hell JW, Westenbroek RE, Warner C, Ahlijanian MK, Prystay W, Gilbert MM, Snutch TP, Catterall WA. Identification and differential subcellular localization of the neuronal class C and class D L-type calcium channel alpha 1 subunits. J Cell Biol. 1993 Nov; 123(4):949-62. PMID: 8227151.
      View in: PubMed
    123. Hell JW, Yokoyama CT, Wong ST, Warner C, Snutch TP, Catterall WA. Differential phosphorylation of two size forms of the neuronal class C L-type calcium channel alpha 1 subunit. J Biol Chem. 1993 Sep 15; 268(26):19451-7. PMID: 8396138.
      View in: PubMed
    124. Catterall WA, de Jongh K, Rotman E, Hell J, Westenbroek R, Dubel SJ, Snutch TP. Molecular properties of calcium channels in skeletal muscle and neurons. Ann N Y Acad Sci. 1993 Jun 21; 681:342-55. PMID: 8395149.
      View in: PubMed
    125. Thomas-Reetz A, Hell JW, During MJ, Walch-Solimena C, Jahn R, De Camilli P. A gamma-aminobutyric acid transporter driven by a proton pump is present in synaptic-like microvesicles of pancreatic beta cells. Proc Natl Acad Sci U S A. 1993 Jun 01; 90(11):5317-21. PMID: 8506380.
      View in: PubMed
    126. Westenbroek RE, Hell JW, Warner C, Dubel SJ, Snutch TP, Catterall WA. Biochemical properties and subcellular distribution of an N-type calcium channel alpha 1 subunit. Neuron. 1992 Dec; 9(6):1099-115. PMID: 1334419.
      View in: PubMed
    127. Dubel SJ, Starr TV, Hell J, Ahlijanian MK, Enyeart JJ, Catterall WA, Snutch TP. Molecular cloning of the alpha-1 subunit of an omega-conotoxin-sensitive calcium channel. Proc Natl Acad Sci U S A. 1992 Jun 01; 89(11):5058-62. PMID: 1317580.
      View in: PubMed
    128. Hell JW, Edelmann L, Hartinger J, Jahn R. Functional reconstitution of the gamma-aminobutyric acid transporter from synaptic vesicles using artificial ion gradients. Biochemistry. 1991 Dec 24; 30(51):11795-800. PMID: 1684290.
      View in: PubMed
    129. Burger PM, Hell J, Mehl E, Krasel C, Lottspeich F, Jahn R. GABA and glycine in synaptic vesicles: storage and transport characteristics. Neuron. 1991 Aug; 7(2):287-93. PMID: 1678614.
      View in: PubMed
    130. Maycox PR, Hell JW, Jahn R. Amino acid neurotransmission: spotlight on synaptic vesicles. Trends Neurosci. 1990 Mar; 13(3):83-7. PMID: 1691873.
      View in: PubMed
    131. Hell JW, Maycox PR, Jahn R. Energy dependence and functional reconstitution of the gamma-aminobutyric acid carrier from synaptic vesicles. J Biol Chem. 1990 Feb 05; 265(4):2111-7. PMID: 1688846.
      View in: PubMed
    132. Jahn R, Hell J, Maycox PR. Synaptic vesicles: key organelles involved in neurotransmission. J Physiol (Paris). 1990; 84(1):128-33. PMID: 1972757.
      View in: PubMed
    133. Maycox PR, Deckwerth T, Hell JW, Jahn R. Glutamate uptake by brain synaptic vesicles. Energy dependence of transport and functional reconstitution in proteoliposomes. J Biol Chem. 1988 Oct 25; 263(30):15423-8. PMID: 2902091.
      View in: PubMed
    134. Hell JW, Maycox PR, Stadler H, Jahn R. Uptake of GABA by rat brain synaptic vesicles isolated by a new procedure. EMBO J. 1988 Oct; 7(10):3023-9. PMID: 2903047.
      View in: PubMed