Loading...

Johannes W Hell

TitleProfessor
InstitutionUniversity of California Davis
DepartmentPharmacology
Address1275 Med Sci Drive
CA 95616
Phone530-752-6540
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Role of a-actinin in Cav1.2 Function
    NIH/NIA R01AG055357Aug 15, 2016 - Apr 30, 2021
    Role: Principal Investigator
    Molecular Mechanisms of Postsynaptic AMPA Receptor Localization
    NIH/NIMH R01MH097887Sep 26, 2014 - Jun 30, 2019
    Role: Principal Investigator
    Signaling by cAMP within Postsynaptic Nanodomains
    NIH/NINDS R01NS078792Aug 15, 2012 - Jun 30, 2017
    Role: Principal Investigator
    Predoctoral Training in Pharmacological Sciences
    NIH/NIGMS T32GM099608Jul 1, 2012 - Jun 30, 2022
    Role: Principal Investigator
    Predoctoral Training in the Pharmacological Sciences
    NIH/NIGMS T32GM067795Jul 1, 2003 - Jun 30, 2022
    Role: Co-Principal Investigator
    The NMDA Receptor Interaction with CaMKII
    NIH/NINDS R01NS046450May 20, 2003 - Apr 30, 2008
    Role: Principal Investigator
    Subcellular Localization of Cav1.2 by a-actinin
    NIH/NIA R56AG017502Dec 1, 1999 - Aug 31, 2016
    Role: Principal Investigator
    Subcellular Localization of Cav1.2 by alpha-actinin
    NIH/NIA R01AG017502Dec 1, 1999 - Sep 30, 2013
    Role: Principal Investigator
    Postsynaptic Signaling Pathways
    NIH/NINDS R01NS035563May 1, 1997 - Jun 30, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Patriarchi T, Buonarati OR, Hell JW. Postsynaptic localization and regulation of AMPA receptors and Cav1.2 by ß2 adrenergic receptor/PKA and Ca2+/CaMKII signaling. EMBO J. 2018 Sep 24. PMID: 30249603.
      View in: PubMed
    2. Ghosh D, Nieves-Cintrón M, Tajada S, Brust-Mascher I, Horne MC, Hell JW, Dixon RE, Santana LF, Navedo MF. Dynamic L-type CaV1.2 channel trafficking facilitates CaV1.2 clustering and cooperative gating. Biochim Biophys Acta. 2018 Jun 27. PMID: 29959960.
      View in: PubMed
    3. Zhang L, Zhang P, Wang G, Zhang H, Zhang Y, Yu Y, Zhang M, Xiao J, Crespo P, Hell JW, Lin L, Huganir RL, Zhu JJ. Ras and Rap Signal Bidirectional Synaptic Plasticity via Distinct Subcellular Microdomains. Neuron. 2018 Apr 24. PMID: 29706584.
      View in: PubMed
    4. Shen A, Nieves-Cintron M, Deng Y, Shi Q, Chowdhury D, Qi J, Hell JW, Navedo MF, Xiang YK. Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell. Nat Commun. 2018 03 13; 9(1):1050. PMID: 29535304.
      View in: PubMed
    5. Chowdhury D, Hell JW. Homeostatic synaptic scaling: molecular regulators of synaptic AMPA-type glutamate receptors. F1000Res. 2018; 7:234. PMID: 29560257.
      View in: PubMed
    6. Matt L, Kim K, Hergarden AC, Patriarchi T, Malik ZA, Park DK, Chowdhury D, Buonarati OR, Henderson PB, Gökçek Saraç Ç, Zhang Y, Mohapatra D, Horne MC, Ames JB, Hell JW. a-Actinin Anchors PSD-95 at Postsynaptic Sites. Neuron. 2018 Mar 07; 97(5):1094-1109.e9. PMID: 29429936.
      View in: PubMed
    7. Sacktor TC, Hell JW. The genetics of PKM? and memory maintenance. Sci Signal. 2017 Nov 14; 10(505). PMID: 29138296.
      View in: PubMed
    8. Chowdhury D, Turner M, Patriarchi T, Hergarden AC, Anderson D, Zhang Y, Sun J, Chen CY, Ames JB, Hell JW. Ca2+/calmodulin binding to PSD-95 mediates homeostatic synaptic scaling down. EMBO J. 2018 Jan 04; 37(1):122-138. PMID: 29118000.
      View in: PubMed
    9. Nieves-Cintrón M, Syed AU, Buonarati OR, Rigor RR, Nystoriak MA, Ghosh D, Sasse KC, Ward SM, Santana LF, Hell JW, Navedo MF. Impaired BKCa channel function in native vascular smooth muscle from humans with type 2 diabetes. Sci Rep. 2017 Oct 25; 7(1):14058. PMID: 29070899.
      View in: PubMed
    10. Buonarati OR, Henderson PB, Murphy GG, Horne MC, Hell JW. Proteolytic processing of the L-type Ca 2+ channel alpha 11.2 subunit in neurons. F1000Res. 2017; 6:1166. PMID: 28781760.
      View in: PubMed
    11. Tseng PY, Henderson PB, Hergarden AC, Patriarchi T, Coleman AM, Lillya MW, Montagut-Bordas C, Lee B, Hell JW, Horne MC. a-Actinin Promotes Surface Localization and Current Density of the Ca2+ Channel CaV1.2 by Binding to the IQ Region of the a1 Subunit. Biochemistry. 2017 07 18; 56(28):3669-3681. PMID: 28613835.
      View in: PubMed
    12. Goodell DJ, Zaegel V, Coultrap SJ, Hell JW, Bayer KU. DAPK1 Mediates LTD by Making CaMKII/GluN2B Binding LTP Specific. Cell Rep. 2017 Jun 13; 19(11):2231-2243. PMID: 28614711.
      View in: PubMed
    13. Horne MC, Hell JW. Angiotensin II signalling kicks out p27Kip1 : casein kinase 2 augmentation of Cav 1.2 L-type Ca2+ channel activity in immature ventricular cardiomyocytes. J Physiol. 2017 Jul 01; 595(13):4131-4132. PMID: 28488737.
      View in: PubMed
    14. Qian H, Patriarchi T, Price JL, Matt L, Lee B, Nieves-Cintrón M, Buonarati OR, Chowdhury D, Nanou E, Nystoriak MA, Catterall WA, Poomvanicha M, Hofmann F, Navedo MF, Hell JW. Phosphorylation of Ser1928 mediates the enhanced activity of the L-type Ca2+ channel Cav1.2 by the ß2-adrenergic receptor in neurons. Sci Signal. 2017 Jan 24; 10(463). PMID: 28119465.
      View in: PubMed
    15. Hell JW, Navedo MF, VanHook AM. Science Signaling Podcast for 24 January 2017: Tissue-specific regulation of L-type calcium channels. Sci Signal. 2017 Jan 24; 10(463). PMID: 28119457.
      View in: PubMed
    16. Nystoriak MA, Nieves-Cintrón M, Patriarchi T, Buonarati OR, Prada MP, Morotti S, Grandi E, Fernandes JD, Forbush K, Hofmann F, Sasse KC, Scott JD, Ward SM, Hell JW, Navedo MF. Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes. Sci Signal. 2017 Jan 24; 10(463). PMID: 28119464.
      View in: PubMed
    17. Chenaux G, Matt L, Hill TC, Kaur I, Liu XB, Kirk LM, Speca DJ, McMahon SA, Zito K, Hell JW, Díaz E. Loss of SynDIG1 Reduces Excitatory Synapse Maturation But Not Formation In Vivo. eNeuro. 2016 Sep-Oct; 3(5). PMID: 27800545.
      View in: PubMed
    18. Barcomb K, Hell JW, Benke TA, Bayer KU. The CaMKII/GluN2B Protein Interaction Maintains Synaptic Strength. J Biol Chem. 2016 07 29; 291(31):16082-9. PMID: 27246855; PMCID: PMC4965558 [Available on 07/29/17].
    19. Gray JA, Zito K, Hell JW. Non-ionotropic signaling by the NMDA receptor: controversy and opportunity. F1000Res. 2016; 5. PMID: 27303637; PMCID: PMC4882754.
    20. Hell JW. How Ca2+-permeable AMPA receptors, the kinase PKA, and the phosphatase PP2B are intertwined in synaptic LTP and LTD. Sci Signal. 2016 04 26; 9(425):e2. PMID: 27117250.
      View in: PubMed
    21. Patriarchi T, Qian H, Di Biase V, Malik ZA, Chowdhury D, Price JL, Hammes EA, Buonarati OR, Westenbroek RE, Catterall WA, Hofmann F, Xiang YK, Murphy GG, Chen CY, Navedo MF, Hell JW. Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the ß2 adrenergic receptor. EMBO J. 2016 06 15; 35(12):1330-45. PMID: 27103070.
      View in: PubMed
    22. Turner M, Anderson DE, Rajan S, Hell JW, Ames JB. Chemical shift assignments of the C-terminal EF-hand domain of a-actinin-1. Biomol NMR Assign. 2016 Apr; 10(1):219-22. PMID: 26861220; PMCID: PMC4789133 [Available on 04/01/17].
    23. He K, Huertas M, Hong SZ, Tie X, Hell JW, Shouval H, Kirkwood A. Distinct Eligibility Traces for LTP and LTD in Cortical Synapses. Neuron. 2015 Nov 04; 88(3):528-38. PMID: 26593091; PMCID: PMC4660261 [Available on 11/04/16].
    24. Atkin G, Moore S, Lu Y, Nelson RF, Tipper N, Rajpal G, Hunt J, Tennant W, Hell JW, Murphy GG, Paulson H. Loss of F-box only protein 2 (Fbxo2) disrupts levels and localization of select NMDA receptor subunits, and promotes aberrant synaptic connectivity. J Neurosci. 2015 Apr 15; 35(15):6165-78. PMID: 25878288; PMCID: PMC4397610.
    25. Malik ZA, Stein IS, Navedo MF, Hell JW. Mission CaMKII?: shuttle calmodulin from membrane to nucleus. Cell. 2014 Oct 09; 159(2):235-7. PMID: 25303520.
      View in: PubMed
    26. Chen CY, Matt L, Hell JW, Rogawski MA. Perampanel inhibition of AMPA receptor currents in cultured hippocampal neurons. PLoS One. 2014; 9(9):e108021. PMID: 25229608; PMCID: PMC4168215.
    27. Stein IS, Donaldson MS, Hell JW. CaMKII binding to GluN2B is important for massed spatial learning in the Morris water maze. F1000Res. 2014; 3:193. PMID: 25187880; PMCID: PMC4149248.
    28. Navedo MF, Hell JW. AKAP5 keeps L-type channels and NFAT on their toes. Cell Rep. 2014 Jun 12; 7(5):1341-1342. PMID: 24926793.
      View in: PubMed
    29. Zhang Y, Matt L, Patriarchi T, Malik ZA, Chowdhury D, Park DK, Renieri A, Ames JB, Hell JW. Capping of the N-terminus of PSD-95 by calmodulin triggers its postsynaptic release. EMBO J. 2014 Jun 17; 33(12):1341-53. PMID: 24705785; PMCID: PMC4194123.
    30. Matt L, Hell JW. LTP: GluN2B on the go. EMBO J. 2014 Apr 16; 33(8):781-2. PMID: 24599308; PMCID: PMC4194105.
    31. Hell JW. CaMKII: claiming center stage in postsynaptic function and organization. Neuron. 2014 Jan 22; 81(2):249-65. PMID: 24462093; PMCID: PMC4570830.
    32. Murphy JA, Stein IS, Lau CG, Peixoto RT, Aman TK, Kaneko N, Aromolaran K, Saulnier JL, Popescu GK, Sabatini BL, Hell JW, Zukin RS. Phosphorylation of Ser1166 on GluN2B by PKA is critical to synaptic NMDA receptor function and Ca2+ signaling in spines. J Neurosci. 2014 Jan 15; 34(3):869-79. PMID: 24431445; PMCID: PMC3891964.
    33. Núñez-Santana FL, Oh MM, Antion MD, Lee A, Hell JW, Disterhoft JF. Surface L-type Ca2+ channel expression levels are increased in aged hippocampus. Aging Cell. 2014 Feb; 13(1):111-20. PMID: 24033980; PMCID: PMC3947046.
    34. Hall DD, Dai S, Tseng PY, Malik Z, Nguyen M, Matt L, Schnizler K, Shephard A, Mohapatra DP, Tsuruta F, Dolmetsch RE, Christel CJ, Lee A, Burette A, Weinberg RJ, Hell JW. Competition between a-actinin and Ca²?-calmodulin controls surface retention of the L-type Ca²? channel Ca(V)1.2. Neuron. 2013 May 08; 78(3):483-97. PMID: 23664615; PMCID: PMC4570828.
    35. Zhang M, Patriarchi T, Stein IS, Qian H, Matt L, Nguyen M, Xiang YK, Hell JW. Adenylyl cyclase anchoring by a kinase anchor protein AKAP5 (AKAP79/150) is important for postsynaptic ß-adrenergic signaling. J Biol Chem. 2013 Jun 14; 288(24):17918-31. PMID: 23649627; PMCID: PMC3682589.
    36. Matt L, Hell JW. PKC?: a new player in LTP coming to the rescue of PKC?'s faltering role in LTP? EMBO J. 2013 May 15; 32(10):1348-9. PMID: 23563118; PMCID: PMC3655469.
    37. Wang D, Fu Q, Zhou Y, Xu B, Shi Q, Igwe B, Matt L, Hell JW, Wisely EV, Oddo S, Xiang YK. ß2 adrenergic receptor, protein kinase A (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in Alzheimer disease models. J Biol Chem. 2013 Apr 12; 288(15):10298-307. PMID: 23430246; PMCID: PMC3624413.
    38. Harvey RD, Hell JW. CaV1.2 signaling complexes in the heart. J Mol Cell Cardiol. 2013 May; 58:143-52. PMID: 23266596; PMCID: PMC3628296.
    39. Hamilton AM, Oh WC, Vega-Ramirez H, Stein IS, Hell JW, Patrick GN, Zito K. Activity-dependent growth of new dendritic spines is regulated by the proteasome. Neuron. 2012 Jun 21; 74(6):1023-30. PMID: 22726833; PMCID: PMC3500563.
    40. Qian H, Matt L, Zhang M, Nguyen M, Patriarchi T, Koval OM, Anderson ME, He K, Lee HK, Hell JW. ß2-Adrenergic receptor supports prolonged theta tetanus-induced LTP. J Neurophysiol. 2012 May; 107(10):2703-12. PMID: 22338020; PMCID: PMC3362273.
    41. Evans TI, Hell JW, Shea MA. Thermodynamic linkage between calmodulin domains binding calcium and contiguous sites in the C-terminal tail of Ca(V)1.2. Biophys Chem. 2011 Nov; 159(1):172-87. PMID: 21757287; PMCID: PMC3340011.
    42. Sanhueza M, Fernandez-Villalobos G, Stein IS, Kasumova G, Zhang P, Bayer KU, Otmakhov N, Hell JW, Lisman J. Role of the CaMKII/NMDA receptor complex in the maintenance of synaptic strength. J Neurosci. 2011 Jun 22; 31(25):9170-8. PMID: 21697368; PMCID: PMC3138556.
    43. Xu H, Ginsburg KS, Hall DD, Zimmermann M, Stein IS, Zhang M, Tandan S, Hill JA, Horne MC, Bers D, Hell JW. Targeting of protein phosphatases PP2A and PP2B to the C-terminus of the L-type calcium channel Ca v1.2. Biochemistry. 2010 Dec 07; 49(48):10298-307. PMID: 21053940; PMCID: PMC3075818.
    44. Hell JW. Beta-adrenergic regulation of the L-type Ca2+ channel Ca(V)1.2 by PKA rekindles excitement. Sci Signal. 2010 Sep 28; 3(141):pe33. PMID: 20876870.
      View in: PubMed
    45. Stein IS, Hell JW. CaMKII hunkers down on the muscarinic M4 receptor to help curb cocaine-induced hyperlocomotion. EMBO J. 2010 Jun 16; 29(12):1943-5. PMID: 20551968; PMCID: PMC2892364.
    46. Joiner ML, Lisé MF, Yuen EY, Kam AY, Zhang M, Hall DD, Malik ZA, Qian H, Chen Y, Ulrich JD, Burette AC, Weinberg RJ, Law PY, El-Husseini A, Yan Z, Hell JW. Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling. EMBO J. 2010 Jan 20; 29(2):482-95. PMID: 19942860; PMCID: PMC2824466.
    47. Tandan S, Wang Y, Wang TT, Jiang N, Hall DD, Hell JW, Luo X, Rothermel BA, Hill JA. Physical and functional interaction between calcineurin and the cardiac L-type Ca2+ channel. Circ Res. 2009 Jul 02; 105(1):51-60. PMID: 19478199; PMCID: PMC3038593.
    48. Hell JW. Hooked on the D3 receptor: CaMKII's new addiction. Neuron. 2009 Feb 12; 61(3):335-6. PMID: 19217370.
      View in: PubMed
    49. Lu Y, Zhang M, Lim IA, Hall DD, Allen M, Medvedeva Y, McKnight GS, Usachev YM, Hell JW. AKAP150-anchored PKA activity is important for LTD during its induction phase. J Physiol. 2008 Sep 01; 586(17):4155-64. PMID: 18617570; PMCID: PMC2652176.
    50. Schnizler K, Shutov LP, Van Kanegan MJ, Merrill MA, Nichols B, McKnight GS, Strack S, Hell JW, Usachev YM. Protein kinase A anchoring via AKAP150 is essential for TRPV1 modulation by forskolin and prostaglandin E2 in mouse sensory neurons. J Neurosci. 2008 May 07; 28(19):4904-17. PMID: 18463244; PMCID: PMC2641040.
    51. Zhou Y, Takahashi E, Li W, Halt A, Wiltgen B, Ehninger D, Li GD, Hell JW, Kennedy MB, Silva AJ. Interactions between the NR2B receptor and CaMKII modulate synaptic plasticity and spatial learning. J Neurosci. 2007 Dec 12; 27(50):13843-53. PMID: 18077696.
      View in: PubMed
    52. Lu Y, Allen M, Halt AR, Weisenhaus M, Dallapiazza RF, Hall DD, Usachev YM, McKnight GS, Hell JW. Age-dependent requirement of AKAP150-anchored PKA and GluR2-lacking AMPA receptors in LTP. EMBO J. 2007 Nov 28; 26(23):4879-90. PMID: 17972919.
      View in: PubMed
    53. Hall DD, Davare MA, Shi M, Allen ML, Weisenhaus M, McKnight GS, Hell JW. Critical role of cAMP-dependent protein kinase anchoring to the L-type calcium channel Cav1.2 via A-kinase anchor protein 150 in neurons. Biochemistry. 2007 Feb 13; 46(6):1635-46. PMID: 17279627.
      View in: PubMed
    54. Murphy GG, Shah V, Hell JW, Silva AJ. Investigation of age-related cognitive decline using mice as a model system: neurophysiological correlates. Am J Geriatr Psychiatry. 2006 Dec; 14(12):1012-21. PMID: 17138808.
      View in: PubMed
    55. Li J, Marionneau C, Zhang R, Shah V, Hell JW, Nerbonne JM, Anderson ME. Calmodulin kinase II inhibition shortens action potential duration by upregulation of K+ currents. Circ Res. 2006 Nov 10; 99(10):1092-9. PMID: 17038644.
      View in: PubMed
    56. Balijepalli RC, Foell JD, Hall DD, Hell JW, Kamp TJ. Localization of cardiac L-type Ca(2+) channels to a caveolar macromolecular signaling complex is required for beta(2)-adrenergic regulation. Proc Natl Acad Sci U S A. 2006 May 09; 103(19):7500-5. PMID: 16648270; PMCID: PMC1564282.
    57. Hall DD, Feekes JA, Arachchige Don AS, Shi M, Hamid J, Chen L, Strack S, Zamponi GW, Horne MC, Hell JW. Binding of protein phosphatase 2A to the L-type calcium channel Cav1.2 next to Ser1928, its main PKA site, is critical for Ser1928 dephosphorylation. Biochemistry. 2006 Mar 14; 45(10):3448-59. PMID: 16519540.
      View in: PubMed
    58. Merrill MA, Chen Y, Strack S, Hell JW. Activity-driven postsynaptic translocation of CaMKII. Trends Pharmacol Sci. 2005 Dec; 26(12):645-53. PMID: 16253351.
      View in: PubMed
    59. Cohen RM, Foell JD, Balijepalli RC, Shah V, Hell JW, Kamp TJ. Unique modulation of L-type Ca2+ channels by short auxiliary beta1d subunit present in cardiac muscle. Am J Physiol Heart Circ Physiol. 2005 May; 288(5):H2363-74. PMID: 15615847.
      View in: PubMed
    60. Davare MA, Hell JW. Increased phosphorylation of the neuronal L-type Ca(2+) channel Ca(v)1.2 during aging. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):16018-23. PMID: 14665691; PMCID: PMC307685.
    61. Lim IA, Merrill MA, Chen Y, Hell JW. Disruption of the NMDA receptor-PSD-95 interaction in hippocampal neurons with no obvious physiological short-term effect. Neuropharmacology. 2003 Nov; 45(6):738-54. PMID: 14529713.
      View in: PubMed
    62. Cottom J, Salvador LM, Maizels ET, Reierstad S, Park Y, Carr DW, Davare MA, Hell JW, Palmer SS, Dent P, Kawakatsu H, Ogata M, Hunzicker-Dunn M. Follicle-stimulating hormone activates extracellular signal-regulated kinase but not extracellular signal-regulated kinase kinase through a 100-kDa phosphotyrosine phosphatase. J Biol Chem. 2003 Feb 28; 278(9):7167-79. PMID: 12493768; PMCID: PMC1564188.
    63. Tavalin SJ, Colledge M, Hell JW, Langeberg LK, Huganir RL, Scott JD. Regulation of GluR1 by the A-kinase anchoring protein 79 (AKAP79) signaling complex shares properties with long-term depression. J Neurosci. 2002 Apr 15; 22(8):3044-51. PMID: 11943807.
      View in: PubMed