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Jon T Sack

Title(s)Associate Professor, Physiology and Membrane Biology
SchoolUniversity of California, Davis
Phone530-752-4131
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    Collapse Research 
    Collapse Research Activities and Funding
    Visualizing endogenous ion channel activation
    NIH/NINDS R01NS096317Sep 30, 2016 - Jun 30, 2020
    Role: Principal Investigator
    Neuronal voltage tracers for photoacoustic imaging in the deep brain
    NIH/NEI R21EY026449Sep 30, 2015 - Aug 31, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Furutani K, Tsumoto K, Chen IS, Handa K, Yamakawa Y, Sack JT, Kurachi Y. Facilitation of IKr current by some hERG channel blockers suppresses early afterdepolarizations. J Gen Physiol. 2019 Feb 04; 151(2):214-230. PMID: 30674563.
      View in: PubMed
    2. Tilley DC, Angueyra JM, Eum KS, Kim H, Chao LH, Peng AW, Sack JT. The tarantula toxin GxTx detains K+ channel gating charges in their resting conformation. J Gen Physiol. 2019 Mar 04; 151(3):292-315. PMID: 30397012.
      View in: PubMed
    3. Kirmiz M, Palacio S, Thapa P, King AN, Sack JT, Trimmer JS. Remodeling neuronal ER-PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels. Mol Biol Cell. 2018 Oct 01; 29(20):2410-2432. PMID: 30091655.
      View in: PubMed
    4. Sepela RJ, Sack JT. Taming unruly chloride channel inhibitors with rational design. Proc Natl Acad Sci U S A. 2018 05 22; 115(21):5311-5313. PMID: 29735705.
      View in: PubMed
    5. Dockendorff C, Gandhi DM, Kimball IH, Eum KS, Rusinova R, Ingólfsson HI, Kapoor R, Peyear T, Dodge MW, Martin SF, Aldrich RW, Andersen OS, Sack JT. Synthetic Analogues of the Snail Toxin 6-Bromo-2-mercaptotryptamine Dimer (BrMT) Reveal That Lipid Bilayer Perturbation Does Not Underlie Its Modulation of Voltage-Gated Potassium Channels. Biochemistry. 2018 05 08; 57(18):2733-2743. PMID: 29616558.
      View in: PubMed
    6. Mann VR, Powers AS, Tilley DC, Sack JT, Cohen BE. Azide-Alkyne Click Conjugation on Quantum Dots by Selective Copper Coordination. ACS Nano. 2018 May 22; 12(5):4469-4477. PMID: 29608274.
      View in: PubMed
    7. Sack JT. The envenomation of general physiology throughout the last century. J Gen Physiol. 2017 Nov 06; 149(11):975-983. PMID: 29021149.
      View in: PubMed
    8. Cobb MM, Austin DC, Sack JT, Trimmer JS. Cell cycle-dependent changes in localization and phosphorylation of the plasma membrane Kv2.1 K+ channel impact endoplasmic reticulum membrane contact sites in COS-1 cells. J Biol Chem. 2016 Mar 11; 291(11):5527. PMID: 26969737; PMCID: PMC4786694.
    9. Thiffault I, Speca DJ, Austin DC, Cobb MM, Eum KS, Safina NP, Grote L, Farrow EG, Miller N, Soden S, Kingsmore SF, Trimmer JS, Saunders CJ, Sack JT. A novel epileptic encephalopathy mutation in KCNB1 disrupts Kv2.1 ion selectivity, expression, and localization. J Gen Physiol. 2015 Nov; 146(5):399-410. PMID: 26503721; PMCID: PMC4621747.
    10. Cobb MM, Austin DC, Sack JT, Trimmer JS. Cell Cycle-dependent Changes in Localization and Phosphorylation of the Plasma Membrane Kv2.1 K+ Channel Impact Endoplasmic Reticulum Membrane Contact Sites in COS-1 Cells. J Biol Chem. 2015 Dec 04; 290(49):29189-201. PMID: 26442584; PMCID: PMC4705925 [Available on 12/04/16].
    11. Sack JT, Tilley DC. What keeps Kv channels small? The molecular physiology of modesty. J Gen Physiol. 2015 Aug; 146(2):123-7. PMID: 26216857; PMCID: PMC4516784.
    12. Gupta K, Zamanian M, Bae C, Milescu M, Krepkiy D, Tilley DC, Sack JT, Yarov-Yarovoy V, Kim JI, Swartz KJ. Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels. Elife. 2015 May 07; 4:e06774. PMID: 25948544; PMCID: PMC4423116.
    13. Tilley DC, Eum KS, Fletcher-Taylor S, Austin DC, Dupré C, Patrón LA, Garcia RL, Lam K, Yarov-Yarovoy V, Cohen BE, Sack JT. Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cells. Proc Natl Acad Sci U S A. 2014 Nov 04; 111(44):E4789-96. PMID: 25331865; PMCID: PMC4226076.
    14. Sack JT, Stephanopoulos N, Austin DC, Francis MB, Trimmer JS. Antibody-guided photoablation of voltage-gated potassium currents. J Gen Physiol. 2013 Sep; 142(3):315-24. PMID: 23940262; PMCID: PMC3753605.
    15. Mandikian D, Cerda O, Sack JT, Trimmer JS. A SUMO-Phospho tag team for wrestling with potassium channel gating. J Gen Physiol. 2011 May; 137(5):435-9. PMID: 21518832; PMCID: PMC3082924.
    16. Al-Sabi A, Shamotienko O, Dhochartaigh SN, Muniyappa N, Le Berre M, Shaban H, Wang J, Sack JT, Dolly JO. Arrangement of Kv1 alpha subunits dictates sensitivity to tetraethylammonium. J Gen Physiol. 2010 Sep; 136(3):273-82. PMID: 20805574; PMCID: PMC2931144.
    17. Sack JT, Shamotienko O, Dolly JO. How to validate a heteromeric ion channel drug target: assessing proper expression of concatenated subunits. J Gen Physiol. 2008 May; 131(5):415-20. PMID: 18411330; PMCID: PMC2346572.
    18. Sack JT, Aldrich RW. Binding of a gating modifier toxin induces intersubunit cooperativity early in the Shaker K channel's activation pathway. J Gen Physiol. 2006 Jul; 128(1):119-32. PMID: 16801385; PMCID: PMC2151558.
    19. Sack JT, Aldrich RW, Gilly WF. A gastropod toxin selectively slows early transitions in the Shaker K channel's activation pathway. J Gen Physiol. 2004 Jun; 123(6):685-96. PMID: 15148327; PMCID: PMC2234574.