Jon T Sack

Title(s)Associate Professor, Physiology and Membrane Biology
SchoolSchool of Medicine
Address4153 Tupper Hall
CA 95616
Phone530-752-4131
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    Collapse Research 
    Collapse Research Activities and Funding
    Visualizing endogenous ion channel activation
    NIH/NINDS R01NS096317Sep 30, 2016 - Jun 30, 2020
    Role: Principal Investigator
    Neuronal voltage tracers for photoacoustic imaging in the deep brain
    NIH/NEI R21EY026449Sep 30, 2015 - Aug 31, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. KvS regulatory subunits confer drug resistance to Kv2 channels. bioRxiv. 2024 Feb 02. Stewart RG, Marquis MJ, Jo S, Ferns M, Sack JT. PMID: 38352561; PMCID: PMC10862871.
      View in: PubMed   Mentions:
    2. Distinct cellular expression and subcellular localization of Kv2 voltage-gated K+ channel subtypes in dorsal root ganglion neurons conserved between mice and humans. J Comp Neurol. 2024 Feb; 532(2):e25575. Stewart RG, Camacena M, Copits BA, Sack JT. PMID: 38335058; PMCID: PMC10861167.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Electrically silent KvS subunits associate with native Kv2 channels in brain and impact diverse properties of channel function. bioRxiv. 2024 Jan 25. Ferns M, van der List D, Vierra NC, Lacey T, Murray K, Kirmiz M, Stewart RG, Sack JT, Trimmer JS. PMID: 38328147; PMCID: PMC10849721.
      View in: PubMed   Mentions:
    4. Distinct cellular expression and subcellular localization of Kv2 voltage-gated K+ channel subtypes in dorsal root ganglion neurons conserved between mice and humans. bioRxiv. 2023 Dec 24. Stewart RG, Camacena M, Copits BA, Sack JT. PMID: 38187582; PMCID: PMC10769185.
      View in: PubMed   Mentions:
    5. Structural modeling of hERG channel-drug interactions using Rosetta. Front Pharmacol. 2023; 14:1244166. Emigh Cortez AM, DeMarco KR, Furutani K, Bekker S, Sack JT, Wulff H, Clancy CE, Vorobyov I, Yarov-Yarovoy V. PMID: 38035013; PMCID: PMC10682396.
      View in: PubMed   Mentions: 1  
    6. Molecular determinants of μ-conotoxin KIIIA interaction with the human voltage-gated sodium channel NaV1.7. Front Pharmacol. 2023; 14:1156855. Kimball IH, Nguyen PT, Olivera BM, Sack JT, Yarov-Yarovoy V. PMID: 37007002; PMCID: PMC10060530.
      View in: PubMed   Mentions: 1  
    7. Computational design of peptides to target NaV1.7 channel with high potency and selectivity for the treatment of pain. Elife. 2022 12 28; 11. Nguyen PT, Nguyen HM, Wagner KM, Stewart RG, Singh V, Thapa P, Chen YJ, Lillya MW, Ton AT, Kondo R, Ghetti A, Pennington MW, Hammock B, Griffith TN, Sack JT, Wulff H, Yarov-Yarovoy V. PMID: 36576241; PMCID: PMC9831606.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    8. Structural modeling of the hERG potassium channel and associated drug interactions. Front Pharmacol. 2022; 13:966463. Maly J, Emigh AM, DeMarco KR, Furutani K, Sack JT, Clancy CE, Vorobyov I, Yarov-Yarovoy V. PMID: 36188564; PMCID: PMC9523588.
      View in: PubMed   Mentions: 6  
    9. Pore opening, not voltage sensor movement, underpins the voltage-dependence of facilitation by a hERG blocker. Mol Pharmacol. 2022 Aug 30. Furutani K, Kawano R, Ichiwara M, Adachi R, Clancy CE, Sack JT, Kita S. PMID: 36041862; PMCID: PMC9595204.
      View in: PubMed   Mentions: 2     Fields:    
    10. Mechanism of use-dependent Kv2 channel inhibition by RY785. J Gen Physiol. 2022 06 06; 154(6). Marquis MJ, Sack JT. PMID: 35435946; PMCID: PMC9195051.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    11. The AMIGO1 adhesion protein activates Kv2.1 voltage sensors. Biophys J. 2022 04 19; 121(8):1395-1416. Sepela RJ, Stewart RG, Valencia LA, Thapa P, Wang Z, Cohen BE, Sack JT. PMID: 35314141; PMCID: PMC9072587.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    12. K+ takes the crown: Selective activation of non-selective crown ether channels. Biophys J. 2022 03 15; 121(6):863-864. Sack JT. PMID: 35219397; PMCID: PMC8943808.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    13. EVAP: A two-photon imaging tool to study conformational changes in endogenous Kv2 channels in live tissues. J Gen Physiol. 2021 11 01; 153(11). Thapa P, Stewart R, Sepela RJ, Vivas O, Parajuli LK, Lillya M, Fletcher-Taylor S, Cohen BE, Zito K, Sack JT. PMID: 34581724; PMCID: PMC8480965.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    14. Molecular determinants of pro-arrhythmia proclivity of d- and l-sotalol via a multi-scale modeling pipeline. J Mol Cell Cardiol. 2021 09; 158:163-177. DeMarco KR, Yang PC, Singh V, Furutani K, Dawson JRD, Jeng MT, Fettinger JC, Bekker S, Ngo VA, Noskov SY, Yarov-Yarovoy V, Sack JT, Wulff H, Clancy CE, Vorobyov I. PMID: 34062207; PMCID: PMC8906354.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    15. Fluorescent toxins as ion channel activity sensors. Methods Enzymol. 2021; 653:295-318. Stewart R, Cohen BE, Sack JT. PMID: 34099176.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    16. Distinguishing Potassium Channel Resting State Conformations in Live Cells with Environment-Sensitive Fluorescence. ACS Chem Neurosci. 2020 08 05; 11(15):2316-2326. Fletcher-Taylor S, Thapa P, Sepela RJ, Kaakati R, Yarov-Yarovoy V, Sack JT, Cohen BE. PMID: 32579336; PMCID: PMC7894042.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    17. Facilitation of IKr current by some hERG channel blockers suppresses early afterdepolarizations. J Gen Physiol. 2019 02 04; 151(2):214-230. Furutani K, Tsumoto K, Chen IS, Handa K, Yamakawa Y, Sack JT, Kurachi Y. PMID: 30674563; PMCID: PMC6363420.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    18. The tarantula toxin GxTx detains K+ channel gating charges in their resting conformation. J Gen Physiol. 2019 03 04; 151(3):292-315. Tilley DC, Angueyra JM, Eum KS, Kim H, Chao LH, Peng AW, Sack JT. PMID: 30397012; PMCID: PMC6400525.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    19. Remodeling neuronal ER-PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels. Mol Biol Cell. 2018 10 01; 29(20):2410-2432. Kirmiz M, Palacio S, Thapa P, King AN, Sack JT, Trimmer JS. PMID: 30091655; PMCID: PMC6233057.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    20. Taming unruly chloride channel inhibitors with rational design. Proc Natl Acad Sci U S A. 2018 05 22; 115(21):5311-5313. Sepela RJ, Sack JT. PMID: 29735705; PMCID: PMC6003517.
      View in: PubMed   Mentions: 2     Fields:    
    21. Synthetic Analogues of the Snail Toxin 6-Bromo-2-mercaptotryptamine Dimer (BrMT) Reveal That Lipid Bilayer Perturbation Does Not Underlie Its Modulation of Voltage-Gated Potassium Channels. Biochemistry. 2018 05 08; 57(18):2733-2743. Dockendorff C, Gandhi DM, Kimball IH, Eum KS, Rusinova R, Ingólfsson HI, Kapoor R, Peyear T, Dodge MW, Martin SF, Aldrich RW, Andersen OS, Sack JT. PMID: 29616558; PMCID: PMC6007853.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    22. Azide-Alkyne Click Conjugation on Quantum Dots by Selective Copper Coordination. ACS Nano. 2018 05 22; 12(5):4469-4477. Mann VR, Powers AS, Tilley DC, Sack JT, Cohen BE. PMID: 29608274; PMCID: PMC5966341.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    23. The envenomation of general physiology throughout the last century. J Gen Physiol. 2017 Nov 06; 149(11):975-983. Sack JT. PMID: 29021149; PMCID: PMC5675992.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    24. Cell cycle-dependent changes in localization and phosphorylation of the plasma membrane Kv2.1 K+ channel impact endoplasmic reticulum membrane contact sites in COS-1 cells. J Biol Chem. 2016 Mar 11; 291(11):5527. Cobb MM, Austin DC, Sack JT, Trimmer JS. PMID: 26969737; PMCID: PMC4786694.
      View in: PubMed   Mentions: 2     Fields:    
    25. A novel epileptic encephalopathy mutation in KCNB1 disrupts Kv2.1 ion selectivity, expression, and localization. J Gen Physiol. 2015 Nov; 146(5):399-410. Thiffault I, Speca DJ, Austin DC, Cobb MM, Eum KS, Safina NP, Grote L, Farrow EG, Miller N, Soden S, Kingsmore SF, Trimmer JS, Saunders CJ, Sack JT. PMID: 26503721; PMCID: PMC4621747.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    26. Cell Cycle-dependent Changes in Localization and Phosphorylation of the Plasma Membrane Kv2.1 K+ Channel Impact Endoplasmic Reticulum Membrane Contact Sites in COS-1 Cells. J Biol Chem. 2015 Dec 04; 290(49):29189-201. Cobb MM, Austin DC, Sack JT, Trimmer JS. PMID: 26442584; PMCID: PMC4705925.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    27. What keeps Kv channels small? The molecular physiology of modesty. J Gen Physiol. 2015 Aug; 146(2):123-7. Sack JT, Tilley DC. PMID: 26216857; PMCID: PMC4516784.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    28. Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels. Elife. 2015 May 07; 4:e06774. Gupta K, Zamanian M, Bae C, Milescu M, Krepkiy D, Tilley DC, Sack JT, Yarov-Yarovoy V, Kim JI, Swartz KJ. PMID: 25948544; PMCID: PMC4423116.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    29. Na+ channel function, regulation, structure, trafficking and sequestration. J Physiol. 2015 Mar 15; 593(6):1347-60. Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM. PMID: 25772290; PMCID: PMC4376415.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    30. Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cells. Proc Natl Acad Sci U S A. 2014 Nov 04; 111(44):E4789-96. Tilley DC, Eum KS, Fletcher-Taylor S, Austin DC, Dupré C, Patrón LA, Garcia RL, Lam K, Yarov-Yarovoy V, Cohen BE, Sack JT. PMID: 25331865; PMCID: PMC4226076.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    31. Phytochemicals perturb membranes and promiscuously alter protein function. ACS Chem Biol. 2014 Aug 15; 9(8):1788-98. Ingólfsson HI, Thakur P, Herold KF, Hobart EA, Ramsey NB, Periole X, de Jong DH, Zwama M, Yilmaz D, Hall K, Maretzky T, Hemmings HC, Blobel C, Marrink SJ, Koçer A, Sack JT, Andersen OS. PMID: 24901212; PMCID: PMC4136704.
      View in: PubMed   Mentions: 107     Fields:    Translation:Cells
    32. Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability. Genes Brain Behav. 2014 Apr; 13(4):394-408. Speca DJ, Ogata G, Mandikian D, Bishop HI, Wiler SW, Eum K, Wenzel HJ, Doisy ET, Matt L, Campi KL, Golub MS, Nerbonne JM, Hell JW, Trainor BC, Sack JT, Schwartzkroin PA, Trimmer JS. PMID: 24494598; PMCID: PMC4077602.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    33. Antibody-guided photoablation of voltage-gated potassium currents. J Gen Physiol. 2013 Sep; 142(3):315-24. Sack JT, Stephanopoulos N, Austin DC, Francis MB, Trimmer JS. PMID: 23940262; PMCID: PMC3753605.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    34. A SUMO-Phospho tag team for wrestling with potassium channel gating. J Gen Physiol. 2011 May; 137(5):435-9. Mandikian D, Cerda O, Sack JT, Trimmer JS. PMID: 21518832; PMCID: PMC3082924.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    35. Arrangement of Kv1 alpha subunits dictates sensitivity to tetraethylammonium. J Gen Physiol. 2010 Sep; 136(3):273-82. Al-Sabi A, Shamotienko O, Dhochartaigh SN, Muniyappa N, Le Berre M, Shaban H, Wang J, Sack JT, Dolly JO. PMID: 20805574; PMCID: PMC2931144.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    36. How to validate a heteromeric ion channel drug target: assessing proper expression of concatenated subunits. J Gen Physiol. 2008 May; 131(5):415-20. Sack JT, Shamotienko O, Dolly JO. PMID: 18411330; PMCID: PMC2346572.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    37. Concatemers of brain Kv1 channel alpha subunits that give similar K+ currents yield pharmacologically distinguishable heteromers. Neuropharmacology. 2007 Aug; 53(2):272-82. Sokolov MV, Shamotienko O, Dhochartaigh SN, Sack JT, Dolly JO. PMID: 17637465.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    38. Binding of a gating modifier toxin induces intersubunit cooperativity early in the Shaker K channel's activation pathway. J Gen Physiol. 2006 Jul; 128(1):119-32. Sack JT, Aldrich RW. PMID: 16801385; PMCID: PMC2151558.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    39. A gastropod toxin selectively slows early transitions in the Shaker K channel's activation pathway. J Gen Physiol. 2004 Jun; 123(6):685-96. Sack JT, Aldrich RW, Gilly WF. PMID: 15148327; PMCID: PMC2234574.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    40. Characterization of a novel gastropod toxin (6-bromo-2-mercaptotryptamine) that inhibits shaker K channel activity. J Biol Chem. 2003 Sep 12; 278(37):34934-42. Kelley WP, Wolters AM, Sack JT, Jockusch RA, Jurchen JC, Williams ER, Sweedler JV, Gilly WF. PMID: 12815055.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
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