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Jon T Sack

Title(s)Associate Professor, Physiology and Membrane Biology
SchoolUniversity of California, Davis
Phone530-752-4131
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    Collapse Research 
    Collapse Research Activities and Funding
    Visualizing endogenous ion channel activation
    NIH/NINDS R01NS096317Sep 30, 2016 - Jun 30, 2020
    Role: Principal Investigator
    Neuronal voltage tracers for photoacoustic imaging in the deep brain
    NIH/NEI R21EY026449Sep 30, 2015 - Aug 31, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Furutani K, Tsumoto K, Chen IS, Handa K, Yamakawa Y, Sack JT, Kurachi Y. Facilitation of IKr current by some hERG channel blockers suppresses early afterdepolarizations. J Gen Physiol. 2019 02 04; 151(2):214-230. PMID: 30674563.
      View in: PubMed
    2. Tilley DC, Angueyra JM, Eum KS, Kim H, Chao LH, Peng AW, Sack JT. The tarantula toxin GxTx detains K+ channel gating charges in their resting conformation. J Gen Physiol. 2019 03 04; 151(3):292-315. PMID: 30397012.
      View in: PubMed
    3. Kirmiz M, Palacio S, Thapa P, King AN, Sack JT, Trimmer JS. Remodeling neuronal ER-PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels. Mol Biol Cell. 2018 10 01; 29(20):2410-2432. PMID: 30091655.
      View in: PubMed
    4. Sepela RJ, Sack JT. Taming unruly chloride channel inhibitors with rational design. Proc Natl Acad Sci U S A. 2018 05 22; 115(21):5311-5313. PMID: 29735705.
      View in: PubMed
    5. Dockendorff C, Gandhi DM, Kimball IH, Eum KS, Rusinova R, Ingólfsson HI, Kapoor R, Peyear T, Dodge MW, Martin SF, Aldrich RW, Andersen OS, Sack JT. Synthetic Analogues of the Snail Toxin 6-Bromo-2-mercaptotryptamine Dimer (BrMT) Reveal That Lipid Bilayer Perturbation Does Not Underlie Its Modulation of Voltage-Gated Potassium Channels. Biochemistry. 2018 05 08; 57(18):2733-2743. PMID: 29616558.
      View in: PubMed
    6. Mann VR, Powers AS, Tilley DC, Sack JT, Cohen BE. Azide-Alkyne Click Conjugation on Quantum Dots by Selective Copper Coordination. ACS Nano. 2018 05 22; 12(5):4469-4477. PMID: 29608274.
      View in: PubMed
    7. Sack JT. The envenomation of general physiology throughout the last century. J Gen Physiol. 2017 Nov 06; 149(11):975-983. PMID: 29021149.
      View in: PubMed
    8. Cobb MM, Austin DC, Sack JT, Trimmer JS. Cell cycle-dependent changes in localization and phosphorylation of the plasma membrane Kv2.1 K+ channel impact endoplasmic reticulum membrane contact sites in COS-1 cells. J Biol Chem. 2016 Mar 11; 291(11):5527. PMID: 26969737.
      View in: PubMed
    9. Thiffault I, Speca DJ, Austin DC, Cobb MM, Eum KS, Safina NP, Grote L, Farrow EG, Miller N, Soden S, Kingsmore SF, Trimmer JS, Saunders CJ, Sack JT. A novel epileptic encephalopathy mutation in KCNB1 disrupts Kv2.1 ion selectivity, expression, and localization. J Gen Physiol. 2015 Nov; 146(5):399-410. PMID: 26503721.
      View in: PubMed
    10. Cobb MM, Austin DC, Sack JT, Trimmer JS. Cell Cycle-dependent Changes in Localization and Phosphorylation of the Plasma Membrane Kv2.1 K+ Channel Impact Endoplasmic Reticulum Membrane Contact Sites in COS-1 Cells. J Biol Chem. 2015 Dec 04; 290(49):29189-201. PMID: 26442584.
      View in: PubMed
    11. Sack JT, Tilley DC. What keeps Kv channels small? The molecular physiology of modesty. J Gen Physiol. 2015 Aug; 146(2):123-7. PMID: 26216857.
      View in: PubMed
    12. Gupta K, Zamanian M, Bae C, Milescu M, Krepkiy D, Tilley DC, Sack JT, Yarov-Yarovoy V, Kim JI, Swartz KJ. Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels. Elife. 2015 May 07; 4:e06774. PMID: 25948544.
      View in: PubMed
    13. Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM. Na+ channel function, regulation, structure, trafficking and sequestration. J Physiol. 2015 Mar 15; 593(6):1347-60. PMID: 25772290.
      View in: PubMed
    14. Tilley DC, Eum KS, Fletcher-Taylor S, Austin DC, Dupré C, Patrón LA, Garcia RL, Lam K, Yarov-Yarovoy V, Cohen BE, Sack JT. Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cells. Proc Natl Acad Sci U S A. 2014 Nov 04; 111(44):E4789-96. PMID: 25331865.
      View in: PubMed
    15. Ingólfsson HI, Thakur P, Herold KF, Hobart EA, Ramsey NB, Periole X, de Jong DH, Zwama M, Yilmaz D, Hall K, Maretzky T, Hemmings HC, Blobel C, Marrink SJ, Koçer A, Sack JT, Andersen OS. Phytochemicals perturb membranes and promiscuously alter protein function. ACS Chem Biol. 2014 Aug 15; 9(8):1788-98. PMID: 24901212.
      View in: PubMed
    16. Speca DJ, Ogata G, Mandikian D, Bishop HI, Wiler SW, Eum K, Wenzel HJ, Doisy ET, Matt L, Campi KL, Golub MS, Nerbonne JM, Hell JW, Trainor BC, Sack JT, Schwartzkroin PA, Trimmer JS. Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability. Genes Brain Behav. 2014 Apr; 13(4):394-408. PMID: 24494598.
      View in: PubMed
    17. Sack JT, Stephanopoulos N, Austin DC, Francis MB, Trimmer JS. Antibody-guided photoablation of voltage-gated potassium currents. J Gen Physiol. 2013 Sep; 142(3):315-24. PMID: 23940262.
      View in: PubMed
    18. Mandikian D, Cerda O, Sack JT, Trimmer JS. A SUMO-Phospho tag team for wrestling with potassium channel gating. J Gen Physiol. 2011 May; 137(5):435-9. PMID: 21518832.
      View in: PubMed
    19. Al-Sabi A, Shamotienko O, Dhochartaigh SN, Muniyappa N, Le Berre M, Shaban H, Wang J, Sack JT, Dolly JO. Arrangement of Kv1 alpha subunits dictates sensitivity to tetraethylammonium. J Gen Physiol. 2010 Sep; 136(3):273-82. PMID: 20805574.
      View in: PubMed
    20. Sack JT, Shamotienko O, Dolly JO. How to validate a heteromeric ion channel drug target: assessing proper expression of concatenated subunits. J Gen Physiol. 2008 May; 131(5):415-20. PMID: 18411330.
      View in: PubMed
    21. Sokolov MV, Shamotienko O, Dhochartaigh SN, Sack JT, Dolly JO. Concatemers of brain Kv1 channel alpha subunits that give similar K+ currents yield pharmacologically distinguishable heteromers. Neuropharmacology. 2007 Aug; 53(2):272-82. PMID: 17637465.
      View in: PubMed
    22. Sack JT, Aldrich RW. Binding of a gating modifier toxin induces intersubunit cooperativity early in the Shaker K channel's activation pathway. J Gen Physiol. 2006 Jul; 128(1):119-32. PMID: 16801385.
      View in: PubMed
    23. Sack JT, Aldrich RW, Gilly WF. A gastropod toxin selectively slows early transitions in the Shaker K channel's activation pathway. J Gen Physiol. 2004 Jun; 123(6):685-96. PMID: 15148327.
      View in: PubMed
    24. Kelley WP, Wolters AM, Sack JT, Jockusch RA, Jurchen JC, Williams ER, Sweedler JV, Gilly WF. Characterization of a novel gastropod toxin (6-bromo-2-mercaptotryptamine) that inhibits shaker K channel activity. J Biol Chem. 2003 Sep 12; 278(37):34934-42. PMID: 12815055.
      View in: PubMed