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A Kv2 inhibitor combination reveals native neuronal conductances consistent with Kv2/KvS heteromers. bioRxiv. 2024 May 14.
Stewart RG, Marquis MJ, Jo S, Aberra A, Cook V, Whiddon Z, Ferns M, Sack JT. PMID: 38352561; PMCID: PMC10862871.
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Electrically silent KvS subunits associate with native Kv2 channels in brain and impact diverse properties of channel function. bioRxiv. 2024 Jan 25.
Ferns M, van der List D, Vierra NC, Lacey T, Murray K, Kirmiz M, Stewart RG, Sack JT, Trimmer JS. PMID: 38328147; PMCID: PMC10849721.
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Dominant and recessive congenital myasthenic syndromes caused by SYT2 mutations. Muscle Nerve. 2021 08; 64(2):219-224.
Maselli RA, Wei DT, Hodgson TS, Sampson JB, Vazquez J, Smith HL, Pytel P, Ferns M. PMID: 34037996.
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6 Fields:
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HumansCells
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An Inside Job: Molecular Determinants for Postsynaptic Localization of Nicotinic Acetylcholine Receptors. Molecules. 2021 May 21; 26(11).
Ferns M. PMID: 34063759; PMCID: PMC8196675.
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2 Fields:
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AnimalsCells
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Recessive congenital myasthenic syndrome caused by a homozygous mutation in SYT2 altering a highly conserved C-terminal amino acid sequence. Am J Med Genet A. 2020 07; 182(7):1744-1749.
Maselli RA, van der Linden H, Ferns M. PMID: 32250532.
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7 Fields:
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HumansCells
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The MX-Helix of Muscle nAChR Subunits Regulates Receptor Assembly and Surface Trafficking. Front Mol Neurosci. 2020; 13:48.
Rudell JC, Borges LS, Yarov-Yarovoy V, Ferns M. PMID: 32265653; PMCID: PMC7105636.
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7
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Pathogenic effects of agrin V1727F mutation are isoform specific and decrease its expression and affinity for HSPGs and LRP4. Hum Mol Genet. 2019 08 15; 28(16):2648-2658.
Rudell JB, Maselli RA, Yarov-Yarovoy V, Ferns MJ. PMID: 30994901; PMCID: PMC6687949.
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8 Fields:
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HumansCells
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Presynaptic congenital myasthenic syndrome with altered synaptic vesicle homeostasis linked to compound heterozygous sequence variants in RPH3A. Mol Genet Genomic Med. 2018 05; 6(3):434-440.
Maselli RA, Vázquez J, Schrumpf L, Arredondo J, Lara M, Strober JB, Pytel P, Wollmann RL, Ferns M. PMID: 29441694; PMCID: PMC6014458.
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PubMed Mentions:
5 Fields:
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HumansCells
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Determinants in the β and δ subunit cytoplasmic loop regulate Golgi trafficking and surface expression of the muscle acetylcholine receptor. J Biol Chem. 2014 Jan 03; 289(1):203-14.
Rudell JC, Borges LS, Rudell JB, Beck KA, Ferns MJ. PMID: 24240098; PMCID: PMC3879544.
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8 Fields:
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HumansAnimalsCells
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Regulation of muscle acetylcholine receptor turnover by β subunit tyrosine phosphorylation. Dev Neurobiol. 2013 May; 73(5):399-410.
Rudell JB, Ferns MJ. PMID: 23325468.
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7 Fields:
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AnimalsCells
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Animal models of antimuscle-specific kinase myasthenia. Ann N Y Acad Sci. 2012 Dec; 1274:140-7.
Richman DP, Nishi K, Ferns MJ, Schnier J, Pytel P, Maselli RA, Agius MA. PMID: 23252909; PMCID: PMC3915870.
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PubMed Mentions:
4 Fields:
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AnimalsCells
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Synaptic basal lamina-associated congenital myasthenic syndromes. Ann N Y Acad Sci. 2012 Dec; 1275:36-48.
Maselli RA, Arredondo J, Ferns MJ, Wollmann RL. PMID: 23278576.
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15 Fields:
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HumansAnimalsCells
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LG2 agrin mutation causing severe congenital myasthenic syndrome mimics functional characteristics of non-neural (z-) agrin. Hum Genet. 2012 Jul; 131(7):1123-35.
Maselli RA, Fernandez JM, Arredondo J, Navarro C, Ngo M, Beeson D, Cagney O, Williams DC, Wollmann RL, Yarov-Yarovoy V, Ferns MJ. PMID: 22205389; PMCID: PMC4795461.
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45 Fields:
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HumansCells
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Acute severe animal model of anti-muscle-specific kinase myasthenia: combined postsynaptic and presynaptic changes. Arch Neurol. 2012 Apr; 69(4):453-60.
Richman DP, Nishi K, Morell SW, Chang JM, Ferns MJ, Wollmann RL, Maselli RA, Schnier J, Agius MA. PMID: 22158720; PMCID: PMC3915865.
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16 Fields:
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AnimalsCells
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Rapsyn interacts with the muscle acetylcholine receptor via alpha-helical domains in the alpha, beta, and epsilon subunit intracellular loops. Neuroscience. 2009 Sep 29; 163(1):222-32.
Lee Y, Rudell J, Ferns M. PMID: 19482062; PMCID: PMC2728176.
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21 Fields:
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AnimalsCells
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Identification of a motif in the acetylcholine receptor beta subunit whose phosphorylation regulates rapsyn association and postsynaptic receptor localization. J Neurosci. 2008 Nov 05; 28(45):11468-76.
Borges LS, Yechikhov S, Lee YI, Rudell JB, Friese MB, Burden SJ, Ferns MJ. PMID: 18987183; PMCID: PMC2606670.
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34 Fields:
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AnimalsCells
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Rapsyn carboxyl terminal domains mediate muscle specific kinase-induced phosphorylation of the muscle acetylcholine receptor. Neuroscience. 2008 Jun 02; 153(4):997-1007.
Lee Y, Rudell J, Yechikhov S, Taylor R, Swope S, Ferns M. PMID: 18436384; PMCID: PMC2587422.
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9 Fields:
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AnimalsCells
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Synaptic transmission is impaired at neuronal autonomic synapses in agrin-null mice. Dev Neurobiol. 2007 Apr; 67(5):521-34.
Gingras J, Rassadi S, Cooper E, Ferns M. PMID: 17443806.
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10 Fields:
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AnimalsCells
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Erratum to “Identification of agrinSN isoform and muscle-specific receptor tyrosine kinase (MuSK) in sperm” [Biochem. Biophys. Res. Commun. 342 (2006) 522–528]. Biochemical and Biophysical Research Communications. 2006 May 1; 344(1):453.
Kumar KP, Ferns FM, Meizel MS. .
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Identification of agrinSN isoform and muscle-specific receptor tyrosine kinase (MuSK) [corrected] in sperm. Biochem Biophys Res Commun. 2006 Apr 07; 342(2):522-8.
Kumar P, Ferns MJ, Meizel S. PMID: 16487930.
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6 Fields:
Translation:
HumansAnimalsCells
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Agrin becomes concentrated at neuroeffector junctions in developing rodent urinary bladder. Cell Tissue Res. 2005 Apr; 320(1):115-25.
Gingras J, Spicer J, Altares M, Zhu Q, Kuchel GA, Ferns M. PMID: 15711988.
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5 Fields:
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AnimalsCells
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Agrin regulates rapsyn interaction with surface acetylcholine receptors, and this underlies cytoskeletal anchoring and clustering. J Biol Chem. 2003 Feb 28; 278(9):7350-9.
Moransard M, Borges LS, Willmann R, Marangi PA, Brenner HR, Ferns MJ, Fuhrer C. PMID: 12486121.
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42 Fields:
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AnimalsCells
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Agrin plays an organizing role in the formation of sympathetic synapses. J Cell Biol. 2002 Sep 16; 158(6):1109-18.
Gingras J, Rassadi S, Cooper E, Ferns M. PMID: 12221070; PMCID: PMC2173215.
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PubMed Mentions:
23 Fields:
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AnimalsCells
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Dual role for calcium in agrin signaling and acetylcholine receptor clustering. J Neurobiol. 2002 Jan; 50(1):69-79.
Borges LS, Lee Y, Ferns M. PMID: 11748634.
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PubMed Mentions:
5 Fields:
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AnimalsCells
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Expression and localization of agrin during sympathetic synapse formation in vitro. J Neurobiol. 2001 Sep 05; 48(3):228-42.
Gingras J, Ferns M. PMID: 11466709.
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7 Fields:
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AnimalsCells
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Challenging the neurocentric view of neuromuscular synapse formation. Neuron. 2001 May; 30(2):311-4.
Ferns M, Carbonetto S. PMID: 11394994.
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5 Fields:
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AnimalsCells
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Agrin-induced phosphorylation of the acetylcholine receptor regulates cytoskeletal anchoring and clustering. J Cell Biol. 2001 Apr 02; 153(1):1-12.
Borges LS, Ferns M. PMID: 11285269; PMCID: PMC2185523.
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40 Fields:
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AnimalsCells
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Agrin-independent activation of the agrin signal transduction pathway. J Neurobiol. 1999 Sep 05; 40(3):356-65.
Grow WA, Ferns M, Gordon H. PMID: 10440735.
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7 Fields:
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AnimalsCells
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A mechanism for acetylcholine receptor clustering distinct from agrin signaling. Dev Neurosci. 1999; 21(6):436-43.
Grow WA, Ferns M, Gordon H. PMID: 10640862.
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4 Fields:
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AnimalsCells
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alpha-Dystroglycan functions in acetylcholine receptor aggregation but is not a coreceptor for agrin-MuSK signaling. J Neurosci. 1998 Aug 15; 18(16):6340-8.
Jacobson C, Montanaro F, Lindenbaum M, Carbonetto S, Ferns M. PMID: 9698325; PMCID: PMC6793207.
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25 Fields:
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AnimalsCells
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Muscle and neural isoforms of agrin increase utrophin expression in cultured myotubes via a transcriptional regulatory mechanism. J Biol Chem. 1998 Jan 09; 273(2):736-43.
Gramolini AO, Burton EA, Tinsley JM, Ferns MJ, Cartaud A, Cartaud J, Davies KE, Lunde JA, Jasmin BJ. PMID: 9422725.
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PubMed Mentions:
24 Fields:
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AnimalsCells
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Neural agrin activates a high-affinity receptor in C2 muscle cells that is unresponsive to muscle agrin. J Neurosci. 1996 Jun 15; 16(12):3791-7.
Bowen DC, Sugiyama J, Ferns M, Hall ZW. PMID: 8656273; PMCID: PMC6578624.
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PubMed Mentions:
10 Fields:
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AnimalsCells
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Agrin-induced acetylcholine receptor clustering in mammalian muscle requires tyrosine phosphorylation. J Cell Biol. 1996 Mar; 132(5):937-44.
Ferns M, Deiner M, Hall Z. PMID: 8603924; PMCID: PMC2120739.
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42 Fields:
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AnimalsCells
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The nicotinic acetylcholine receptor at the neuromuscular junction: assembly and tyrosine phosphorylation. Cold Spring Harb Symp Quant Biol. 1996; 61:363-71.
Wang ZZ, Fuhrer C, Shtrom S, Sugiyama JE, Ferns MJ, Hall ZW. PMID: 9246465.
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1 Fields:
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HumansAnimalsCells
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Chick wing innervation. III. Formation of axon collaterals in developing peripheral nerves. J Comp Neurol. 1995 Jun 26; 357(2):272-80.
Ferns MJ, Hollyday M. PMID: 7665729.
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4 Fields:
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AnimalsCells
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The ability of agrin to cluster AChRs depends on alternative splicing and on cell surface proteoglycans. Neuron. 1993 Sep; 11(3):491-502.
Ferns MJ, Campanelli JT, Hoch W, Scheller RH, Hall Z. PMID: 8398142.
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93 Fields:
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AnimalsCells
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Developmental regulation of highly active alternatively spliced forms of agrin. Neuron. 1993 Sep; 11(3):479-90.
Hoch W, Ferns M, Campanelli JT, Hall ZW, Scheller RH. PMID: 8398141.
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53 Fields:
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AnimalsCells
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Motor innervation of dorsoventrally reversed wings in chick/quail chimeric embryos. J Neurosci. 1993 Jun; 13(6):2463-76.
Ferns MJ, Hollyday M. PMID: 8501518; PMCID: PMC6576488.
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PubMed Mentions:
7 Fields:
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AnimalsCells
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How many agrins does it take to make a synapse? Cell. 1992 Jul 10; 70(1):1-3.
Ferns MJ, Hall ZW. PMID: 1320460.
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20 Fields:
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AnimalsCells
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RNA splicing regulates agrin-mediated acetylcholine receptor clustering activity on cultured myotubes. Neuron. 1992 Jun; 8(6):1079-86.
Ferns M, Hoch W, Campanelli JT, Rupp F, Hall ZW, Scheller RH. PMID: 1319184.
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53 Fields:
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AnimalsCells
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Agrin: a synaptic basal lamina protein that regulates development of the neuromuscular junction. Cold Spring Harb Symp Quant Biol. 1992; 57:461-72.
Campanelli JT, Ferns M, Hoch W, Rupp F, von Zastrow M, Hall Z, Scheller RH. PMID: 1339682.
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6 Fields:
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AnimalsCells
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Peripheral competition in the control of sensory neuron numbers in Xenopus frogs reared with a single bilaterally innervated hindlimb. Brain Res Dev Brain Res. 1989 Jan 01; 45(1):149-53.
Lamb AH, Ferns MJ, Klose K. PMID: 2917408.
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AnimalsCells