James Trimmer

InstitutionUniversity of California Davis
Address1163 Life Sciences
CA 95616
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    1. Kirmiz M, Palacio S, Thapa P, King AN, Sack JT, Trimmer J. Remodeling neuronal ER-PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels. Mol Biol Cell. 2018 Aug 09; mbcE18050337. PMID: 30091655.
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    2. Kirmiz M, Vierra NC, Palacio S, Trimmer J. Identification of VAPA and VAPB as Kv2 channel-interacting proteins defining endoplasmic reticulum-plasma membrane junctions in mammalian brain neurons. J Neurosci. 2018 Jul 16. PMID: 30012696.
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    3. Bishop HI, Cobb MM, Kirmiz M, Parajuli LK, Mandikian D, Philp AM, Melnik M, Kuja-Panula J, Rauvala H, Shigemoto R, Murray KD, Trimmer J. Kv2 Ion Channels Determine the Expression and Localization of the Associated AMIGO-1 Cell Adhesion Molecule in Adult Brain Neurons. Front Mol Neurosci. 2018; 11:1. PMID: 29403353.
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    4. Jensen CS, Watanabe S, Stas JI, Klaphaak J, Yamane A, Schmitt N, Olesen SP, Trimmer J, Rasmussen HB, Misonou H. Trafficking of Kv2.1 Channels to the Axon Initial Segment by a Novel Nonconventional Secretory Pathway. J Neurosci. 2017 Nov 29; 37(48):11523-11536. PMID: 29042434.
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    5. Speca DJ, Trimmer J, Peterson AS, Díaz E. Whole exome sequencing reveals a functional mutation in the GAIN domain of the Bai2 receptor underlying a forward mutagenesis hyperactivity QTL. Mamm Genome. 2017 Dec; 28(11-12):465-475. PMID: 28894906.
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    6. Palacio S, Chevaleyre V, Brann DH, Murray KD, Piskorowski RA, Trimmer J. Heterogeneity in Kv2 Channel Expression Shapes Action Potential Characteristics and Firing Patterns in CA1 versus CA2 Hippocampal Pyramidal Neurons. eNeuro. 2017 Jul-Aug; 4(4). PMID: 28856240.
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    7. Kirk LM, Ti SW, Bishop HI, Orozco-Llamas M, Pham M, Trimmer J, Díaz E. Distribution of the SynDIG4/proline-rich transmembrane protein 1 in rat brain. J Comp Neurol. 2016 Aug 01; 524(11):2266-80. PMID: 26660156; PMCID: PMC4892943 [Available on 08/01/17].
    8. Gong B, Murray KD, Trimmer J. Developing high-quality mouse monoclonal antibodies for neuroscience research - approaches, perspectives and opportunities. N Biotechnol. 2016 Sep 25; 33(5 Pt A):551-64. PMID: 26644354; PMCID: PMC4884554 [Available on 09/25/17].
    9. Bishop HI, Guan D, Bocksteins E, Parajuli LK, Murray KD, Cobb MM, Misonou H, Zito K, Foehring RC, Trimmer J. Distinct Cell- and Layer-Specific Expression Patterns and Independent Regulation of Kv2 Channel Subtypes in Cortical Pyramidal Neurons. J Neurosci. 2015 Nov 04; 35(44):14922-42. PMID: 26538660; PMCID: PMC4635138.
    10. Cobb MM, Austin DC, Sack JT, Trimmer J. Cell Cycle-dependent Changes in Localization and Phosphorylation of the Plasma Membrane Kv2.1 K+ Channel Impact Endoplasmic Reticulum Membrane Contact Sites in COS-1 Cells. J Biol Chem. 2015 Dec 04; 290(49):29189-201. PMID: 26442584; PMCID: PMC4705925 [Available on 12/04/16].
    11. Cáceres M, Ortiz L, Recabarren T, Romero A, Colombo A, Leiva-Salcedo E, Varela D, Rivas J, Silva I, Morales D, Campusano C, Almarza O, Simon F, Toledo H, Park KS, Trimmer J, Cerda O. TRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility. PLoS One. 2015; 10(6):e0130540. PMID: 26110647; PMCID: PMC4482413.
    12. Trimmer J. Subcellular localization of K+ channels in mammalian brain neurons: remarkable precision in the midst of extraordinary complexity. Neuron. 2015 Jan 21; 85(2):238-56. PMID: 25611506; PMCID: PMC4303806.
    13. Trimmer J. Clarification of previously published perspective. Epilepsia. 2014 Sep; 55(9):1469. PMID: 25223507.
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    14. King AN, Manning CF, Trimmer J. A unique ion channel clustering domain on the axon initial segment of mammalian neurons. J Comp Neurol. 2014 Aug 01; 522(11):2594-608. PMID: 24477962; PMCID: PMC4133991.
    15. Mandikian D, Bocksteins E, Parajuli LK, Bishop HI, Cerda O, Shigemoto R, Trimmer J. Cell type-specific spatial and functional coupling between mammalian brain Kv2.1 K+ channels and ryanodine receptors. J Comp Neurol. 2014 Oct 15; 522(15):3555-74. PMID: 24962901; PMCID: PMC4139460.
    16. Baek JH, Rubinstein M, Scheuer T, Trimmer J. Reciprocal changes in phosphorylation and methylation of mammalian brain sodium channels in response to seizures. J Biol Chem. 2014 May 30; 289(22):15363-73. PMID: 24737319; PMCID: PMC4140893.
    17. Trimmer J. Ion channels and pain: important steps towards validating a new therapeutic target for neuropathic pain. Exp Neurol. 2014 Apr; 254:190-4. PMID: 24508559; PMCID: PMC4118296.
    18. Sack JT, Stephanopoulos N, Austin DC, Francis MB, Trimmer J. Antibody-guided photoablation of voltage-gated potassium currents. J Gen Physiol. 2013 Sep; 142(3):315-24. PMID: 23940262; PMCID: PMC3753605.
    19. Vacher H, Trimmer J. Trafficking mechanisms underlying neuronal voltage-gated ion channel localization at the axon initial segment. Epilepsia. 2012 Dec; 53 Suppl 9:21-31. PMID: 23216576; PMCID: PMC3531813.
    20. Manning CF, Bundros AM, Trimmer J. Benefits and pitfalls of secondary antibodies: why choosing the right secondary is of primary importance. PLoS One. 2012; 7(6):e38313. PMID: 22675541; PMCID: PMC3365890.
    21. Menegola M, Clark E, Trimmer J. The importance of immunohistochemical analyses in evaluating the phenotype of Kv channel knockout mice. Epilepsia. 2012 Jun; 53 Suppl 1:142-9. PMID: 22612819; PMCID: PMC3369274.
    22. Vacher H, Trimmer J. Diverse roles for auxiliary subunits in phosphorylation-dependent regulation of mammalian brain voltage-gated potassium channels. Pflugers Arch. 2011 Nov; 462(5):631-43. PMID: 21822597; PMCID: PMC3371647.
    23. Cerda O, Trimmer J. Activity-dependent phosphorylation of neuronal Kv2.1 potassium channels by CDK5. J Biol Chem. 2011 Aug 19; 286(33):28738-48. PMID: 21712386; PMCID: PMC3190682.
    24. Mandikian D, Cerda O, Sack JT, Trimmer J. A SUMO-Phospho tag team for wrestling with potassium channel gating. J Gen Physiol. 2011 May; 137(5):435-9. PMID: 21518832; PMCID: PMC3082924.
    25. Vacher H, Yang JW, Cerda O, Autillo-Touati A, Dargent B, Trimmer J. Cdk-mediated phosphorylation of the Kvß2 auxiliary subunit regulates Kv1 channel axonal targeting. J Cell Biol. 2011 Mar 07; 192(5):813-24. PMID: 21357749; PMCID: PMC3051814.
    26. Cerda O, Baek JH, Trimmer J. Mining recent brain proteomic databases for ion channel phosphosite nuggets. J Gen Physiol. 2011 Jan; 137(1):3-16. PMID: 21149544; PMCID: PMC3010060.
    27. Baek JH, Cerda O, Trimmer J. Mass spectrometry-based phosphoproteomics reveals multisite phosphorylation on mammalian brain voltage-gated sodium and potassium channels. Semin Cell Dev Biol. 2011 Apr; 22(2):153-9. PMID: 20932926; PMCID: PMC3043121.
    28. Cerda O, Trimmer J. Analysis and functional implications of phosphorylation of neuronal voltage-gated potassium channels. Neurosci Lett. 2010 Dec 10; 486(2):60-7. PMID: 20600597; PMCID: PMC3365921.
    29. Berendt FJ, Park KS, Trimmer J. Multisite phosphorylation of voltage-gated sodium channel alpha subunits from rat brain. J Proteome Res. 2010 Apr 05; 9(4):1976-84. PMID: 20131913; PMCID: PMC2849892.
    30. Kalashnikova E, Lorca RA, Kaur I, Barisone GA, Li B, Ishimaru T, Trimmer J, Mohapatra DP, Díaz E. SynDIG1: an activity-regulated, AMPA- receptor-interacting transmembrane protein that regulates excitatory synapse development. Neuron. 2010 Jan 14; 65(1):80-93. PMID: 20152115; PMCID: PMC2822728.
    31. Seikel E, Trimmer J. Convergent modulation of Kv4.2 channel alpha subunits by structurally distinct DPPX and KChIP auxiliary subunits. Biochemistry. 2009 Jun 23; 48(24):5721-30. PMID: 19441798; PMCID: PMC2733230.
    32. Mohapatra DP, Misonou H, Pan SJ, Held JE, Surmeier DJ, Trimmer J. Regulation of intrinsic excitability in hippocampal neurons by activity-dependent modulation of the KV2.1 potassium channel. Channels (Austin). 2009 Jan-Feb; 3(1):46-56. PMID: 19276663; PMCID: PMC2743964.
    33. Vacher H, Mohapatra DP, Trimmer J. Localization and targeting of voltage-dependent ion channels in mammalian central neurons. Physiol Rev. 2008 Oct; 88(4):1407-47. PMID: 18923186; PMCID: PMC2587220.
    34. Martinez HD, Jasavala RJ, Hinkson I, Fitzgerald LD, Trimmer J, Kung HJ, Wright ME. RNA editing of androgen receptor gene transcripts in prostate cancer cells. J Biol Chem. 2008 Oct 31; 283(44):29938-49. PMID: 18708348; PMCID: PMC2662061.
    35. Yan J, Olsen JV, Park KS, Li W, Bildl W, Schulte U, Aldrich RW, Fakler B, Trimmer J. Profiling the phospho-status of the BKCa channel alpha subunit in rat brain reveals unexpected patterns and complexity. Mol Cell Proteomics. 2008 Nov; 7(11):2188-98. PMID: 18573811; PMCID: PMC2577206.
    36. Ogawa Y, Horresh I, Trimmer J, Bredt DS, Peles E, Rasband MN. Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2. J Neurosci. 2008 May 28; 28(22):5731-9. PMID: 18509034; PMCID: PMC2729199.
    37. Mohapatra DP, Siino DF, Trimmer J. Interdomain cytoplasmic interactions govern the intracellular trafficking, gating, and modulation of the Kv2.1 channel. J Neurosci. 2008 May 07; 28(19):4982-94. PMID: 18463252; PMCID: PMC3409667.
    38. Rhodes KJ, Trimmer J. Antibody-based validation of CNS ion channel drug targets. J Gen Physiol. 2008 May; 131(5):407-13. PMID: 18411328; PMCID: PMC2346570.
    39. Park KS, Yang JW, Seikel E, Trimmer J. Potassium channel phosphorylation in excitable cells: providing dynamic functional variability to a diverse family of ion channels. Physiology (Bethesda). 2008 Feb; 23:49-57. PMID: 18268365.
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    40. Yang JW, Vacher H, Park KS, Clark E, Trimmer J. Trafficking-dependent phosphorylation of Kv1.2 regulates voltage-gated potassium channel cell surface expression. Proc Natl Acad Sci U S A. 2007 Dec 11; 104(50):20055-60. PMID: 18056633; PMCID: PMC2148421.
    41. Wenzel HJ, Vacher H, Clark E, Trimmer J, Lee AL, Sapolsky RM, Tempel BL, Schwartzkroin PA. Structural consequences of Kcna1 gene deletion and transfer in the mouse hippocampus. Epilepsia. 2007 Nov; 48(11):2023-46. PMID: 17651419; PMCID: PMC2752664.
    42. Mohapatra DP, Vacher H, Trimmer J. The surprising catch of a voltage-gated potassium channel in a neuronal SNARE. Sci STKE. 2007 Jul 03; 2007(393):pe37. PMID: 17609479.
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    43. Park KS, Mohapatra DP, Trimmer J. Proteomic analyses of K(v)2.1 channel phosphorylation sites determining cell background specific differences in function. Channels (Austin). 2007 Mar-Apr; 1(2):59-61. PMID: 18690023.
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    44. Rasmussen HB, Frøkjaer-Jensen C, Jensen CS, Jensen HS, Jørgensen NK, Misonou H, Trimmer J, Olesen SP, Schmitt N. Requirement of subunit co-assembly and ankyrin-G for M-channel localization at the axon initial segment. J Cell Sci. 2007 Mar 15; 120(Pt 6):953-63. PMID: 17311847.
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    45. Van Wart A, Trimmer J, Matthews G. Polarized distribution of ion channels within microdomains of the axon initial segment. J Comp Neurol. 2007 Jan 10; 500(2):339-52. PMID: 17111377.
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    46. Misonou H, Menegola M, Mohapatra DP, Guy LK, Park KS, Trimmer J. Bidirectional activity-dependent regulation of neuronal ion channel phosphorylation. J Neurosci. 2006 Dec 27; 26(52):13505-14. PMID: 17192433.
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    47. Vacher H, Mohapatra DP, Misonou H, Trimmer J. Regulation of Kv1 channel trafficking by the mamba snake neurotoxin dendrotoxin K. FASEB J. 2007 Mar; 21(3):906-14. PMID: 17185748; PMCID: PMC2737685.
    48. Menegola M, Trimmer J. Unanticipated region- and cell-specific downregulation of individual KChIP auxiliary subunit isotypes in Kv4.2 knock-out mouse brain. J Neurosci. 2006 Nov 22; 26(47):12137-42. PMID: 17122038.
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    49. Clark E, Vacher H, Trimmer J. Kv1.1 takes a deTOR from the axon to the dendrite. Neuron. 2006 Nov 09; 52(3):399-401. PMID: 17088206.
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    50. Park KS, Mohapatra DP, Misonou H, Trimmer J. Graded regulation of the Kv2.1 potassium channel by variable phosphorylation. Science. 2006 Aug 18; 313(5789):976-9. PMID: 16917065.
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    51. Rhodes KJ, Trimmer J. Antibodies as valuable neuroscience research tools versus reagents of mass distraction. J Neurosci. 2006 Aug 02; 26(31):8017-20. PMID: 16885215.
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    52. Misonou H, Menegola M, Buchwalder L, Park EW, Meredith A, Rhodes KJ, Aldrich RW, Trimmer J. Immunolocalization of the Ca2+-activated K+ channel Slo1 in axons and nerve terminals of mammalian brain and cultured neurons. J Comp Neurol. 2006 May 20; 496(3):289-302. PMID: 16566008; PMCID: PMC2605666.
    53. Mohapatra DP, Trimmer J. The Kv2.1 C terminus can autonomously transfer Kv2.1-like phosphorylation-dependent localization, voltage-dependent gating, and muscarinic modulation to diverse Kv channels. J Neurosci. 2006 Jan 11; 26(2):685-95. PMID: 16407566.
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    54. Misonou H, Mohapatra DP, Menegola M, Trimmer J. Calcium- and metabolic state-dependent modulation of the voltage-dependent Kv2.1 channel regulates neuronal excitability in response to ischemia. J Neurosci. 2005 Nov 30; 25(48):11184-93. PMID: 16319318.
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    55. Misonou H, Mohapatra DP, Trimmer J. Kv2.1: a voltage-gated k+ channel critical to dynamic control of neuronal excitability. Neurotoxicology. 2005 Oct; 26(5):743-52. PMID: 15950285.
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    56. Strassle BW, Menegola M, Rhodes KJ, Trimmer J. Light and electron microscopic analysis of KChIP and Kv4 localization in rat cerebellar granule cells. J Comp Neurol. 2005 Apr 04; 484(2):144-55. PMID: 15736227.
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    57. Van Wart A, Boiko T, Trimmer J, Matthews G. Novel clustering of sodium channel Na(v)1.1 with ankyrin-G and neurofascin at discrete sites in the inner plexiform layer of the retina. Mol Cell Neurosci. 2005 Apr; 28(4):661-73. PMID: 15797713.
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    58. Misonou H, Trimmer J. A primary culture system for biochemical analyses of neuronal proteins. J Neurosci Methods. 2005 Jun 15; 144(2):165-73. PMID: 15910974.
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    59. Pyott SJ, Glowatzki E, Trimmer J, Aldrich RW. Extrasynaptic localization of inactivating calcium-activated potassium channels in mouse inner hair cells. J Neurosci. 2004 Oct 27; 24(43):9469-74. PMID: 15509733.
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    60. Trimmer J. Peering into the birth canal during ion channel parturition. Neuron. 2004 Oct 14; 44(2):214-6. PMID: 15473959.
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    61. Manganas LN, Trimmer J. Calnexin regulates mammalian Kv1 channel trafficking. Biochem Biophys Res Commun. 2004 Sep 17; 322(2):577-84. PMID: 15325269.
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    62. Rhodes KJ, Carroll KI, Sung MA, Doliveira LC, Monaghan MM, Burke SL, Strassle BW, Buchwalder L, Menegola M, Cao J, An WF, Trimmer J. KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain. J Neurosci. 2004 Sep 08; 24(36):7903-15. PMID: 15356203.
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    63. Misonou H, Mohapatra DP, Park EW, Leung V, Zhen D, Misonou K, Anderson AE, Trimmer J. Regulation of ion channel localization and phosphorylation by neuronal activity. Nat Neurosci. 2004 Jul; 7(7):711-8. PMID: 15195093.
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    64. Misonou H, Trimmer J. Determinants of voltage-gated potassium channel surface expression and localization in Mammalian neurons. Crit Rev Biochem Mol Biol. 2004 May-Jun; 39(3):125-45. PMID: 15596548.
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    65. Shibasaki K, Nakahira K, Trimmer J, Shibata R, Akita M, Watanabe S, Ikenaka K. Mossy fibre contact triggers the targeting of Kv4.2 potassium channels to dendrites and synapses in developing cerebellar granule neurons. J Neurochem. 2004 May; 89(4):897-907. PMID: 15140189.
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    66. Trimmer J, Rhodes KJ. Localization of voltage-gated ion channels in mammalian brain. Annu Rev Physiol. 2004; 66:477-519. PMID: 14977411.
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    67. Shibata R, Misonou H, Campomanes CR, Anderson AE, Schrader LA, Doliveira LC, Carroll KI, Sweatt JD, Rhodes KJ, Trimmer J. A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels. J Biol Chem. 2003 Sep 19; 278(38):36445-54. PMID: 12829703.
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    68. Boiko T, Van Wart A, Caldwell JH, Levinson SR, Trimmer J, Matthews G. Functional specialization of the axon initial segment by isoform-specific sodium channel targeting. J Neurosci. 2003 Mar 15; 23(6):2306-13. PMID: 12657689.
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    69. Rasband MN, Park EW, Zhen D, Arbuckle MI, Poliak S, Peles E, Grant SG, Trimmer J. Clustering of neuronal potassium channels is independent of their interaction with PSD-95. J Cell Biol. 2002 Nov 25; 159(4):663-72. PMID: 12438413; PMCID: PMC2173099.
    70. Guo W, Li H, Aimond F, Johns DC, Rhodes KJ, Trimmer J, Nerbonne JM. Role of heteromultimers in the generation of myocardial transient outward K+ currents. Circ Res. 2002 Mar 22; 90(5):586-93. PMID: 11909823.
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    71. Campomanes CR, Carroll KI, Manganas LN, Hershberger ME, Gong B, Antonucci DE, Rhodes KJ, Trimmer J. Kv beta subunit oxidoreductase activity and Kv1 potassium channel trafficking. J Biol Chem. 2002 Mar 08; 277(10):8298-305. PMID: 11748234.
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