Heike Wulff

Title(s)Professor, Pharmacology
SchoolSchool of Medicine
Address3513 GBSF
CA 95616
Phone530-754-6135
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    Collapse Research 
    Collapse Research Activities and Funding
    The Role of KCa3.1 in Microglial function and in Parkinsons disease pathogenesis
    NIH R01NS124226Jul 15, 2021 - Apr 30, 2026
    Role: Co-Principal Investigator
    Optimization of non-addictive biologics to target sodium channels involved in pain signaling
    NIH UG3NS114956Sep 30, 2019 - Aug 31, 2021
    Role: Co-Principal Investigator
    Identifying Molecular Targets for the Proconvulsant Activity of TETS
    NIH R21NS110647Jul 1, 2019 - Jun 30, 2021
    Role: Co-Principal Investigator
    Microglial K+ Channels in Ischemic Stroke
    NIH R01NS100294May 1, 2017 - Feb 28, 2021
    Role: Principal Investigator
    Structure Assisted Design of SK Channel Selective Activators
    NIH R21NS101876Feb 1, 2017 - Jul 31, 2020
    Role: Principal Investigator
    Optimization of KCa2 Channel Activators as Neuroscience Tools and Potential Drugs
    NIH R21NS072585Aug 1, 2011 - May 31, 2014
    Role: Principal Investigator
    The Microglial Kv1.3 Channel in Alzheimer's Disease
    NIH R21AG038910Aug 1, 2011 - Jun 30, 2013
    Role: Co-Principal Investigator
    Design of Slack Channel Activators
    NIH R21NS073943Apr 1, 2011 - Mar 31, 2013
    Role: Co-Principal Investigator
    Microglial Potassium Channels in Ischemic Stroke
    NIH R56NS098328Jul 1, 2006 - Jul 31, 2018
    Role: Principal Investigator
    The microglial potassium channels Kv1.3 and KCa3.1 as therapeutic targets for neu
    NIH R01GM076063Jul 1, 2006 - Jun 30, 2016
    Role: Principal Investigator
    Small Molecule Kv1.3 Blockers as New Therapeutics for Multiple Sclerosis
    NIH R21NS053426Jan 1, 2006 - Jun 30, 2008
    Role: Principal Investigator
    SK Channel Openers as Therapeutics for Cerebellar Ataxia
    NIH R21NS052165Jul 15, 2005 - Apr 30, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Reduction of inflammation and mitochondrial degeneration in mutant SOD1 mice through inhibition of voltage-gated potassium channel Kv1.3. Front Mol Neurosci. 2023; 16:1333745. Ratano P, Cocozza G, Pinchera C, Busdraghi LM, Cantando I, Martinello K, Scioli M, Rosito M, Bezzi P, Fucile S, Wulff H, Limatola C, D'Alessandro G. PMID: 38292023; PMCID: PMC10824952.
      View in: PubMed   Mentions:
    2. Elucidating molecular mechanisms of protoxin-II state-specific binding to the human NaV1.7 channel. J Gen Physiol. 2024 Feb 05; 156(2). Ngo K, Lopez Mateos D, Han Y, Rouen KC, Ahn SH, Wulff H, Clancy CE, Yarov-Yarovoy V, Vorobyov I. PMID: 38127314; PMCID: PMC10737443.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Structural modeling of hERG channel-drug interactions using Rosetta. Front Pharmacol. 2023; 14:1244166. Emigh Cortez AM, DeMarco KR, Furutani K, Bekker S, Sack JT, Wulff H, Clancy CE, Vorobyov I, Yarov-Yarovoy V. PMID: 38035013; PMCID: PMC10682396.
      View in: PubMed   Mentions: 1  
    4. Ca2+-regulated expression of high affinity methylaminoisobutryic acid transport in hippocampal neurons inhibited by riluzole and novel neuroprotective aminothiazoles. Curr Res Physiol. 2023; 6:100109. Erickson JD, Kyllo T, Wulff H. PMID: 38107787; PMCID: PMC10724208.
      View in: PubMed   Mentions:
    5. The Concise Guide to PHARMACOLOGY 2023/24: Ion channels. Br J Pharmacol. 2023 Oct; 180 Suppl 2:S145-S222. Alexander SPH, Mathie AA, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Davies JA, Aldrich RW, Attali B, Baggetta AM, Becirovic E, Biel M, Bill RM, Caceres AI, Catterall WA, Conner AC, Davies P, De Clerq K, Delling M, Di Virgilio F, Falzoni S, Fenske S, Fortuny-Gomez A, Fountain S, George C, Goldstein SAN, Grimm C, Grissmer S, Ha K, Hammelmann V, Hanukoglu I, Hu M, Ijzerman AP, Jabba SV, Jarvis M, Jensen AA, Jordt SE, Kaczmarek LK, Kellenberger S, Kennedy C, King B, Kitchen P, Liu Q, Lynch JW, Meades J, Mehlfeld V, Nicke A, Offermanns S, Perez-Reyes E, Plant LD, Rash L, Ren D, Salman MM, Sieghart W, Sivilotti LG, Smart TG, Snutch TP, Tian J, Trimmer JS, Van den Eynde C, Vriens J, Wei AD, Winn BT, Wulff H, Xu H, Yang F, Fang W, Yue L, Zhang X, Zhu M. PMID: 38123150.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Elucidating Molecular Mechanisms of Protoxin-2 State-specific Binding to the Human NaV1.7 Channel. bioRxiv. 2023 Jun 15. Ngo K, Mateos DL, Han Y, Rouen KC, Ahn SH, Wulff H, Clancy CE, Yarov-Yarovoy V, Vorobyov I. PMID: 36909474; PMCID: PMC10002706.
      View in: PubMed   Mentions:
    7. Aflatoxin B1 Increases Soluble Epoxide Hydrolase in the Brain and Induces Neuroinflammation and Dopaminergic Neurotoxicity. Int J Mol Sci. 2023 Jun 09; 24(12). Wang W, Wang Y, Wagner KM, Lee RD, Hwang SH, Morisseau C, Wulff H, Hammock BD. PMID: 37373086; PMCID: PMC10298596.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    8. Immunocytoprotection after reperfusion with Kv1.3 inhibitors has an extended treatment window for ischemic stroke. Front Pharmacol. 2023; 14:1190476. Lee RD, Chen YJ, Singh L, Nguyen HM, Wulff H. PMID: 37180699; PMCID: PMC10166874.
      View in: PubMed   Mentions:
    9. Repurposing the KCa3.1 Blocker Senicapoc for Ischemic Stroke. Transl Stroke Res. 2023 Apr 24. Lee RD, Chen YJ, Nguyen HM, Singh L, Dietrich CJ, Pyles BR, Cui Y, Weinstein JR, Wulff H. PMID: 37088858.
      View in: PubMed   Mentions: 1     Fields:    
    10. Endothelial KCa channels: Novel targets to reduce atherosclerosis-driven vascular dysfunction. Front Pharmacol. 2023; 14:1151244. Vera OD, Wulff H, Braun AP. PMID: 37063294; PMCID: PMC10102451.
      View in: PubMed   Mentions: 2  
    11. Involvement of KCa3.1 channel activity in immediate perioperative cognitive and neuroinflammatory outcomes. BMC Anesthesiol. 2023 03 16; 23(1):80. Saxena S, Nuyens V, Rodts C, Jamar K, Albert A, Seidel L, Cherkaoui-Malki M, Boogaerts JG, Wulff H, Maze M, Kruys V, Vamecq J. PMID: 36927341; PMCID: PMC10018926.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    12. Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) causes seizure activity in larval zebrafish via antagonism of γ-aminobutyric acid type A receptor α1β2γ2. Arch Toxicol. 2023 05; 97(5):1355-1365. Mundy PC, Werner A, Singh L, Singh V, Mendieta R, Patullo CE, Wulff H, Lein PJ. PMID: 36912926; PMCID: PMC10110628.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    13. Computational design of peptides to target NaV1.7 channel with high potency and selectivity for the treatment of pain. Elife. 2022 12 28; 11. Nguyen PT, Nguyen HM, Wagner KM, Stewart RG, Singh V, Thapa P, Chen YJ, Lillya MW, Ton AT, Kondo R, Ghetti A, Pennington MW, Hammock B, Griffith TN, Sack JT, Wulff H, Yarov-Yarovoy V. PMID: 36576241; PMCID: PMC9831606.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    14. Riluzole and novel naphthalenyl substituted aminothiazole derivatives prevent acute neural excitotoxic injury in a rat model of temporal lobe epilepsy. Neuropharmacology. 2023 02 15; 224:109349. Kyllo T, Singh V, Shim H, Latika S, Nguyen HM, Chen YJ, Terry E, Wulff H, Erickson JD. PMID: 36436594; PMCID: PMC9843824.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    15. Can KCa3.1 channel activators serve as novel inhibitors of platelet aggregation? J Thromb Haemost. 2022 11; 20(11):2488-2490. Wulff H, Braun AP, Alper SL. PMID: 36271464.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Apamin structure and pharmacology revisited. Front Pharmacol. 2022; 13:977440. Kuzmenkov AI, Peigneur S, Nasburg JA, Mineev KS, Nikolaev MV, Pinheiro-Junior EL, Arseniev AS, Wulff H, Tytgat J, Vassilevski AA. PMID: 36188602; PMCID: PMC9523135.
      View in: PubMed   Mentions: 6  
    17. Editorial: Venoms, animal and microbial toxins, volume II. Front Pharmacol. 2022; 13:973628. Cao Z, Shahbazzadeh D, Kovacic H, McNutt PM, Wang JL, Wulff H, Utkin Y, Sabatier JM. PMID: 36059944; PMCID: PMC9439662.
      View in: PubMed   Mentions:
    18. The erythroid K-Cl cotransport inhibitor [(dihydroindenyl)oxy]acetic acid blocks erythroid Ca2+-activated K+ channel KCNN4. Am J Physiol Cell Physiol. 2022 09 01; 323(3):C694-C705. Rivera A, Nasburg JA, Shim H, Shmukler BE, Kitten J, Wohlgemuth JG, Dlott JS, Snyder LM, Brugnara C, Wulff H, Alper SL. PMID: 35848620; PMCID: PMC9448282.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    19. Editorial: Ion Channels and Transporters in Ca2+ -Dependent Functions of Lymphocytes. Front Physiol. 2022; 13:962110. Hajdu P, Wulff H, Niemeyer BA, Szabó I. PMID: 35874512; PMCID: PMC9301300.
      View in: PubMed   Mentions:
    20. Effects of TRAM-34 and minocycline on neuroinflammation caused by diabetic ketoacidosis in a rat model. BMJ Open Diabetes Res Care. 2022 05; 10(3). Glaser N, Chu S, Weiner J, Zdepski L, Wulff H, Tancredi D, ODonnell ME. PMID: 35584854; PMCID: PMC9119135.
      View in: PubMed   Mentions: 1  Translation:HumansAnimals
    21. Discovery of Novel Activators of Large-Conductance Calcium-Activated Potassium Channels for the Treatment of Cerebellar Ataxia. Mol Pharmacol. 2022 07; 102(1):438-449. Srinivasan SR, Huang H, Chang WC, Nasburg JA, Nguyen HM, Strassmaier T, Wulff H, Shakkottai VG. PMID: 35489717; PMCID: PMC9341255.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    22. Pose Classification Using Three-Dimensional Atomic Structure-Based Neural Networks Applied to Ion Channel-Ligand Docking. J Chem Inf Model. 2022 05 23; 62(10):2301-2315. Shim H, Kim H, Allen JE, Wulff H. PMID: 35447030; PMCID: PMC9131459.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    23. Muscle Damage in Dystrophic mdx Mice Is Influenced by the Activity of Ca2+-Activated KCa3.1 Channels. Life (Basel). 2022 Apr 05; 12(4). Morotti M, Garofalo S, Cocozza G, Antonangeli F, Bianconi V, Mozzetta C, De Stefano ME, Capitani R, Wulff H, Limatola C, Catalano M, Grassi F. PMID: 35455028; PMCID: PMC9025295.
      View in: PubMed   Mentions: 1  
    24. The seizure-inducing plastic explosive RDX inhibits the α1β2γ2 GABAA receptor. Ann Clin Transl Neurol. 2022 05; 9(5):600-609. Pressly B, Lee RD, Singh V, Pessah IN, Wulff H. PMID: 35324073; PMCID: PMC9082378.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    25. Channelopathy-causing mutations in the S45A/S45B and HA/HB helices of KCa2.3 and KCa3.1 channels alter their apparent Ca2+ sensitivity. Cell Calcium. 2022 03; 102:102538. Orfali R, Nam YW, Nguyen HM, Rahman MA, Yang G, Cui M, Wulff H, Zhang M. PMID: 35030515; PMCID: PMC8844225.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    26. Structure-Activity Relationship Study of Subtype-Selective Positive Modulators of KCa2 Channels. J Med Chem. 2022 01 13; 65(1):303-322. El-Sayed NS, Nam YW, Egorova PA, Nguyen HM, Orfali R, Rahman MA, Yang G, Wulff H, Bezprozvanny I, Parang K, Zhang M. PMID: 34962403; PMCID: PMC8758555.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    27. Kv1.3 inhibition attenuates neuroinflammation through disruption of microglial calcium signaling. Channels (Austin). 2021 12; 15(1):67-78. Fomina AF, Nguyen HM, Wulff H. PMID: 33356832; PMCID: PMC7781540.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    28. The potassium channel Kv1.3 as a therapeutic target for immunocytoprotection after reperfusion. Ann Clin Transl Neurol. 2021 10; 8(10):2070-2082. Chen YJ, Cui Y, Singh L, Wulff H. PMID: 34617690; PMCID: PMC8528456.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    29. The feeding behaviour of Amyotrophic Lateral Sclerosis mouse models is modulated by the Ca2+ -activated KCa 3.1 channels. Br J Pharmacol. 2021 12; 178(24):4891-4906. Cocozza G, Garofalo S, Morotti M, Chece G, Grimaldi A, Lecce M, Scavizzi F, Menghini R, Casagrande V, Federici M, Raspa M, Wulff H, Limatola C. PMID: 34411281; PMCID: PMC9293222.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    30. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels. Br J Pharmacol. 2021 Oct; 178 Suppl 1:S157-S245. Alexander SP, Mathie A, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Aldrich RW, Attali B, Baggetta AM, Becirovic E, Biel M, Bill RM, Catterall WA, Conner AC, Davies P, Delling M, Virgilio FD, Falzoni S, Fenske S, George C, Goldstein SAN, Grissmer S, Ha K, Hammelmann V, Hanukoglu I, Jarvis M, Jensen AA, Kaczmarek LK, Kellenberger S, Kennedy C, King B, Kitchen P, Lynch JW, Perez-Reyes E, Plant LD, Rash L, Ren D, Salman MM, Sivilotti LG, Smart TG, Snutch TP, Tian J, Trimmer JS, Van den Eynde C, Vriens J, Wei AD, Winn BT, Wulff H, Xu H, Yue L, Zhang X, Zhu M. PMID: 34529831.
      View in: PubMed   Mentions: 69     Fields:    Translation:Humans
    31. The efficacy of γ-aminobutyric acid type A receptor (GABA AR) subtype-selective positive allosteric modulators in blocking tetramethylenedisulfotetramine (TETS)-induced seizure-like behavior in larval zebrafish with minimal sedation. Toxicol Appl Pharmacol. 2021 09 01; 426:115643. Mundy PC, Pressly B, Carty DR, Yaghoobi B, Wulff H, Lein PJ. PMID: 34265354; PMCID: PMC8514104.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    32. Molecular determinants of pro-arrhythmia proclivity of d- and l-sotalol via a multi-scale modeling pipeline. J Mol Cell Cardiol. 2021 09; 158:163-177. DeMarco KR, Yang PC, Singh V, Furutani K, Dawson JRD, Jeng MT, Fettinger JC, Bekker S, Ngo VA, Noskov SY, Yarov-Yarovoy V, Sack JT, Wulff H, Clancy CE, Vorobyov I. PMID: 34062207; PMCID: PMC8906354.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    33. Editorial: Venoms, Animal and Microbial Toxins. Front Pharmacol. 2021; 12:706573. Cao Z, Wang JL, McNutt PM, Utkin YN, Shahbazzadeh D, Wulff H, Kovacic H, Sabatier JM. PMID: 34122121; PMCID: PMC8188234.
      View in: PubMed   Mentions:
    34. Structure-Activity Relationship of Neuroactive Steroids, Midazolam, and Perampanel Toward Mitigating Tetramine-Triggered Activity in Murine Hippocampal Neuronal Networks. Toxicol Sci. 2021 04 12; 180(2):325-341. Antrobus S, Pressly B, Nik AM, Wulff H, Pessah IN. PMID: 33483729; PMCID: PMC8599726.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    35. Unique molecular characteristics and microglial origin of Kv1.3 channel-positive brain myeloid cells in Alzheimer's disease. Proc Natl Acad Sci U S A. 2021 03 16; 118(11). Ramesha S, Rayaprolu S, Bowen CA, Giver CR, Bitarafan S, Nguyen HM, Gao T, Chen MJ, Nwabueze N, Dammer EB, Engstrom AK, Xiao H, Pennati A, Seyfried NT, Katz DJ, Galipeau J, Wulff H, Waller EK, Wood LB, Levey AI, Rangaraju S. PMID: 33649184; PMCID: PMC7980378.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    36. ATP-evoked intracellular Ca2+ transients shape the ionic permeability of human microglia from epileptic temporal cortex. J Neuroinflammation. 2021 Feb 15; 18(1):44. Palomba NP, Martinello K, Cocozza G, Casciato S, Mascia A, Di Gennaro G, Morace R, Esposito V, Wulff H, Limatola C, Fucile S. PMID: 33588880; PMCID: PMC7883449.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    37. A non-hallucinogenic psychedelic analogue with therapeutic potential. Nature. 2021 01; 589(7842):474-479. Cameron LP, Tombari RJ, Lu J, Pell AJ, Hurley ZQ, Ehinger Y, Vargas MV, McCarroll MN, Taylor JC, Myers-Turnbull D, Liu T, Yaghoobi B, Laskowski LJ, Anderson EI, Zhang G, Viswanathan J, Brown BM, Tjia M, Dunlap LE, Rabow ZT, Fiehn O, Wulff H, McCorvy JD, Lein PJ, Kokel D, Ron D, Peters J, Zuo Y, Olson DE. PMID: 33299186; PMCID: PMC7874389.
      View in: PubMed   Mentions: 110     Fields:    Translation:Animals
    38. Acute and chronic neuroinflammation is triggered by diabetic ketoacidosis in a rat model. BMJ Open Diabetes Res Care. 2020 12; 8(2). Glaser N, Chu S, Hung B, Fernandez L, Wulff H, Tancredi D, ODonnell ME. PMID: 33318070; PMCID: PMC7737057.
      View in: PubMed   Mentions: 7  Translation:HumansAnimals
    39. New capsaicin analogs as molecular rulers to define the permissive conformation of the mouse TRPV1 ligand-binding pocket. Elife. 2020 11 09; 9. Vu S, Singh V, Wulff H, Yarov-Yarovoy V, Zheng J. PMID: 33164749; PMCID: PMC7671684.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    40. Identification of the Functional Binding Site for the Convulsant Tetramethylenedisulfotetramine in the Pore of the α2β3γ2 GABAA Receptor. Mol Pharmacol. 2021 01; 99(1):78-91. Pressly B, Lee RD, Barnych B, Hammock BD, Wulff H. PMID: 33109687; PMCID: PMC7746976.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    41. KCa channel activation normalizes endothelial function in Type 2 Diabetic resistance arteries by improving intracellular Ca2+ mobilization. Metabolism. 2021 01; 114:154390. Mishra RC, Kyle BD, Kendrick DJ, Svystonyuk D, Kieser TM, Fedak PWM, Wulff H, Braun AP. PMID: 33039407; PMCID: PMC7736096.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    42. Acute administration of diazepam or midazolam minimally alters long-term neuropathological effects in the rat brain following acute intoxication with diisopropylfluorophosphate. Eur J Pharmacol. 2020 Nov 05; 886:173538. Supasai S, González EA, Rowland DJ, Hobson B, Bruun DA, Guignet MA, Soares S, Singh V, Wulff H, Saito N, Harvey DJ, Lein PJ. PMID: 32898549; PMCID: PMC7572820.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    43. Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease. J Clin Invest. 2020 08 03; 130(8):4195-4212. Sarkar S, Nguyen HM, Malovic E, Luo J, Langley M, Palanisamy BN, Singh N, Manne S, Neal M, Gabrielle M, Abdalla A, Anantharam P, Rokad D, Panicker N, Singh V, Ay M, Charli A, Harischandra D, Jin LW, Jin H, Rangaraju S, Anantharam V, Wulff H, Kanthasamy AG. PMID: 32597830; PMCID: PMC7410064.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    44. Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice. Br J Anaesth. 2020 09; 125(3):298-307. Lai IK, Valdearcos M, Morioka K, Saxena S, Feng X, Li R, Uchida Y, Lijun A, Li W, Pan J, Koliwad S, Marcucio R, Wulff H, Maze M. PMID: 32624183; PMCID: PMC7497028.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    45. Biophysical basis for Kv1.3 regulation of membrane potential changes induced by P2X4-mediated calcium entry in microglia. Glia. 2020 11; 68(11):2377-2394. Nguyen HM, di Lucente J, Chen YJ, Cui Y, Ibrahim RH, Pennington MW, Jin LW, Maezawa I, Wulff H. PMID: 32525239; PMCID: PMC7540709.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    46. Modulation of Lymphocyte Potassium Channel KV1.3 by Membrane-Penetrating, Joint-Targeting Immunomodulatory Plant Defensin. ACS Pharmacol Transl Sci. 2020 Aug 14; 3(4):720-736. Ong ST, Bajaj S, Tanner MR, Chang SC, Krishnarjuna B, Ng XR, Morales RAV, Chen MW, Luo D, Patel D, Yasmin S, Ng JJH, Zhuang Z, Nguyen HM, El Sahili A, Lescar J, Patil R, Charman SA, Robins EG, Goggi JL, Tan PW, Sadasivam P, Ramasamy B, Hartimath SV, Dhawan V, Bednenko J, Colussi P, Wulff H, Pennington MW, Kuyucak S, Norton RS, Beeton C, Chandy KG. PMID: 32832873; PMCID: PMC7432667.
      View in: PubMed   Mentions: 11  
    47. Comparison of the toxicokinetics of the convulsants picrotoxinin and tetramethylenedisulfotetramine (TETS) in mice. Arch Toxicol. 2020 06; 94(6):1995-2007. Pressly B, Vasylieva N, Barnych B, Singh V, Singh L, Bruun DA, Hwang SH, Chen YJ, Fettinger JC, Johnnides S, Lein PJ, Yang J, Hammock BD, Wulff H. PMID: 32239239; PMCID: PMC7303059.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    48. Conditional KCa3.1-transgene induction in murine skin produces pruritic eczematous dermatitis with severe epidermal hyperplasia and hyperkeratosis. PLoS One. 2020; 15(3):e0222619. Lozano-Gerona J, Oliván-Viguera A, Delgado-Wicke P, Singh V, Brown BM, Tapia-Casellas E, Pueyo E, Valero MS, Garcia-Otín ÁL, Giraldo P, Abarca-Lachen E, Surra JC, Osada J, Hamilton KL, Raychaudhuri SP, Marigil M, Juarranz Á, Wulff H, Miura H, Gilaberte Y, Köhler R. PMID: 32150577; PMCID: PMC7062274.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    49. Susceptibility of larval zebrafish to the seizurogenic activity of GABA type A receptor antagonists. Neurotoxicology. 2020 01; 76:220-234. Bandara SB, Carty DR, Singh V, Harvey DJ, Vasylieva N, Pressly B, Wulff H, Lein PJ. PMID: 31811871; PMCID: PMC6957304.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    50. SKA-31, an activator of Ca2+-activated K+ channels, improves cardiovascular function in aging. Pharmacol Res. 2020 01; 151:104539. John CM, Khaddaj Mallat R, Mishra RC, George G, Singh V, Turnbull JD, Umeshappa CS, Kendrick DJ, Kim T, Fauzi FM, Visser F, Fedak PWM, Wulff H, Braun AP. PMID: 31707036; PMCID: PMC6956598.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    51. The Trials and Tribulations of Structure Assisted Design of KCa Channel Activators. Front Pharmacol. 2019; 10:972. Shim H, Brown BM, Singh L, Singh V, Fettinger JC, Yarov-Yarovoy V, Wulff H. PMID: 31616290; PMCID: PMC6764326.
      View in: PubMed   Mentions: 10  
    52. Extracellular K+ Dampens T Cell Functions: Implications for Immune Suppression in the Tumor Microenvironment. Bioelectricity. 2019 Sep 01; 1(3):169-179. Ong ST, Ng AS, Ng XR, Zhuang Z, Wong BHS, Prasannan P, Kok YJ, Bi X, Shim H, Wulff H, Chandy KG, Verma NK. PMID: 34471819; PMCID: PMC8370284.
      View in: PubMed   Mentions: 13  
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    59. Ca2+-activated K+ channels modulate microglia affecting motor neuron survival in hSOD1G93A mice. Brain Behav Immun. 2018 10; 73:584-595. Cocozza G, di Castro MA, Carbonari L, Grimaldi A, Antonangeli F, Garofalo S, Porzia A, Madonna M, Mainiero F, Santoni A, Grassi F, Wulff H, D'Alessandro G, Limatola C. PMID: 29981425; PMCID: PMC6129409.
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    63. Correction to Optimized Inhibitors of Soluble Epoxide Hydrolase Improve in Vitro Target Residence Time and in Vivo Efficacy. J Med Chem. 2018 05 10; 61(9):4271. Lee KSS, Liu JY, Wagner KM, Pakhomova S, Dong H, Morisseau C, Fu SH, Yang J, Wang P, Ulu A, Mate CA, Nguyen LV, Hwang SH, Edin ML, Mara AA, Wulff H, Newcomer ME, Zeldin DC, Hammock BD. PMID: 29701466; PMCID: PMC5949719.
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    66. Targeting potassium channels to treat cerebellar ataxia. Ann Clin Transl Neurol. 2018 03; 5(3):297-314. Bushart DD, Chopra R, Singh V, Murphy GG, Wulff H, Shakkottai VG. PMID: 29560375; PMCID: PMC5846455.
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    70. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview. Br J Pharmacol. 2017 Dec; 174 Suppl 1:S1-S16. Alexander SP, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA, CGTP Collaborators. PMID: 29055037; PMCID: PMC5650665.
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    78. From the Cover: BDE-47 and BDE-49 Inhibit Axonal Growth in Primary Rat Hippocampal Neuron-Glia Co-Cultures via Ryanodine Receptor-Dependent Mechanisms. Toxicol Sci. 2017 04 01; 156(2):375-386. Chen H, Streifel KM, Singh V, Yang D, Mangini L, Wulff H, Lein PJ. PMID: 28003438; PMCID: PMC6070026.
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    83. Chapter 7 Blood-Brain Barrier Mechanisms of Edema Formation The Role of Ion Transporters and Channels. . 2017 Jan 1; 129-149. O’Donnell OM, Wulff WH, Chen CY. .
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    90. Endothelial Small- and Intermediate-Conductance K Channels and Endothelium-Dependent Hyperpolarization as Drug Targets in Cardiovascular Disease. Adv Pharmacol. 2016; 77:65-104. Köhler R, Oliván-Viguera A, Wulff H. PMID: 27451095.
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    93. Vascular Reactivity Profile of Novel KCa 3.1-Selective Positive-Gating Modulators in the Coronary Vascular Bed. Basic Clin Pharmacol Toxicol. 2016 Aug; 119(2):184-92. Oliván-Viguera A, Valero MS, Pinilla E, Amor S, García-Villalón ÁL, Coleman N, Laría C, Calvín-Tienza V, García-Otín ÁL, Fernández-Fernández JM, Murillo MD, Gálvez JA, Díaz-de-Villegas MD, Badorrey R, Simonsen U, Rivera L, Wulff H, Köhler R. PMID: 26821335; PMCID: PMC5720859.
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    94. Chasing the Elusive Benzofuran Impurity of the THR Antagonist NH-3: Synthesis, Isotope Labeling, and Biological Activity. J Org Chem. 2016 Mar 04; 81(5):1870-6. Singh L, Pressly B, Mengeling BJ, Fettinger JC, Furlow JD, Lein PJ, Wulff H, Singh V. PMID: 26849160.
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    95. Diisopropylfluorophosphate Impairs the Transport of Membrane-Bound Organelles in Rat Cortical Axons. J Pharmacol Exp Ther. 2016 Mar; 356(3):645-55. Gao J, Naughton SX, Wulff H, Singh V, Beck WD, Magrane J, Thomas B, Kaidery NA, Hernandez CM, Terry AV. PMID: 26718240; PMCID: PMC4767389.
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    100. Neuronal Atrophy Early in Degenerative Ataxia Is a Compensatory Mechanism to Regulate Membrane Excitability. J Neurosci. 2015 Aug 12; 35(32):11292-307. Dell'Orco JM, Wasserman AH, Chopra R, Ingram MA, Hu YS, Singh V, Wulff H, Opal P, Orr HT, Shakkottai VG. PMID: 26269637; PMCID: PMC4532759.
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    103. Inhibition of Myogenic Tone in Rat Cremaster and Cerebral Arteries by SKA-31, an Activator of Endothelial KCa2.3 and KCa3.1 Channels. J Cardiovasc Pharmacol. 2015 Jul; 66(1):118-27. Mishra RC, Wulff H, Hill MA, Braun AP. PMID: 25815673; PMCID: PMC4500737.
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    104. Human lung myofibroblast TGFβ1-dependent Smad2/3 signalling is Ca(2+)-dependent and regulated by KCa3.1 K(+) channels. Fibrogenesis Tissue Repair. 2015; 8:5. Roach KM, Feghali-Bostwick C, Wulff H, Amrani Y, Bradding P. PMID: 25829947; PMCID: PMC4379608.
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    108. Ion channels in innate and adaptive immunity. Annu Rev Immunol. 2015; 33:291-353. Feske S, Wulff H, Skolnik EY. PMID: 25861976; PMCID: PMC4822408.
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    117. Preserved regulation of renal perfusion pressure by small and intermediate conductance KCa channels in hypertensive mice with or without renal failure. Pflugers Arch. 2015 Apr; 467(4):817-31. Waeckel L, Bertin F, Clavreul N, Damery T, Köhler R, Paysant J, Sansilvestri-Morel P, Simonet S, Vayssettes-Courchay C, Wulff H, Verbeuren TJ, Félétou M. PMID: 24903240.
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    118. Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases. FASEB J. 2014 Sep; 28(9):3952-64. Chhabra S, Chang SC, Nguyen HM, Huq R, Tanner MR, Londono LM, Estrada R, Dhawan V, Chauhan S, Upadhyay SK, Gindin M, Hotez PJ, Valenzuela JG, Mohanty B, Swarbrick JD, Wulff H, Iadonato SP, Gutman GA, Beeton C, Pennington MW, Norton RS, Chandy KG. PMID: 24891519; PMCID: PMC4139903.
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    119. Expression of T-cell KV1.3 potassium channel correlates with pro-inflammatory cytokines and disease activity in ulcerative colitis. J Crohns Colitis. 2014 Nov; 8(11):1378-91. Koch Hansen L, Sevelsted-Møller L, Rabjerg M, Larsen D, Hansen TP, Klinge L, Wulff H, Knudsen T, Kjeldsen J, Köhler R. PMID: 24793818; PMCID: PMC4216648.
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    120. A pharmacologic activator of endothelial KCa channels enhances coronary flow in the hearts of type 2 diabetic rats. J Mol Cell Cardiol. 2014 Jul; 72:364-73. Mishra RC, Wulff H, Cole WC, Braun AP. PMID: 24787473.
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    121. Alterations in cerebellar physiology are associated with a stiff-legged gait in Atcay(ji-hes) mice. Neurobiol Dis. 2014 Jul; 67:140-8. Luna-Cancalon K, Sikora KM, Pappas SS, Singh V, Wulff H, Paulson HL, Burmeister M, Shakkottai VG. PMID: 24727095; PMCID: PMC4059535.
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    122. Nanomolar bifenthrin alters synchronous Ca2+ oscillations and cortical neuron development independent of sodium channel activity. Mol Pharmacol. 2014 Apr; 85(4):630-9. Cao Z, Cui Y, Nguyen HM, Jenkins DP, Wulff H, Pessah IN. PMID: 24482397; PMCID: PMC3965893.
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    123. Correction: The K+ Channel KCa3.1 as a Novel Target for Idiopathic Pulmonary Fibrosis. PLoS ONE. 2014 Jan 16; 9(1). Roach RK, Duffy DS, Coward CW, Feghali-Bostwick FC, Wulff WH, Bradding BP. .
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    124. The K+ channel KCa3.1 as a novel target for idiopathic pulmonary fibrosis. PLoS One. 2013; 8(12):e85244. Roach KM, Roach KM, Duffy SM, Coward W, Feghali-Bostwick C, Wulff H, Bradding P. PMID: 24392001; PMCID: PMC3877378.
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    125. The Ca²⁺-activated K⁺ channel KCa3.1 as a potential new target for the prevention of allograft vasculopathy. PLoS One. 2013; 8(11):e81006. Chen YJ, Lam J, Gregory CR, Schrepfer S, Wulff H. PMID: 24312257; PMCID: PMC3843675.
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    126. Development of a QPatch automated electrophysiology assay for identifying KCa3.1 inhibitors and activators. Assay Drug Dev Technol. 2013 Nov-Dec; 11(9-10):551-60. Jenkins DP, Yu W, Brown BM, Løjkner LD, Wulff H. PMID: 24351043; PMCID: PMC3870577.
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    127. Blocking KCa3.1 channels increases tumor cell killing by a subpopulation of human natural killer lymphocytes. PLoS One. 2013; 8(10):e76740. Koshy S, Wu D, Hu X, Tajhya RB, Huq R, Khan FS, Pennington MW, Wulff H, Yotnda P, Beeton C. PMID: 24146918; PMCID: PMC3795664.
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    128. Activation of KCa3.1 by SKA-31 induces arteriolar dilatation and lowers blood pressure in normo- and hypertensive connexin40-deficient mice. Br J Pharmacol. 2013 Sep; 170(2):293-303. Radtke J, Schmidt K, Wulff H, Köhler R, de Wit C. PMID: 23734697; PMCID: PMC3834754.
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    129. KCa3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo. Cell Death Dis. 2013 Aug 15; 4:e773. D'Alessandro G, Catalano M, Sciaccaluga M, Chece G, Cipriani R, Rosito M, Grimaldi A, Lauro C, Cantore G, Santoro A, Fioretti B, Franciolini F, Wulff H, Limatola C. PMID: 23949222; PMCID: PMC3763441.
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    130. Channels: Sticking to nooks and crannies. Nat Chem Biol. 2013 Aug; 9(8):473-4. Wulff H, Yarov-Yarovoy V. PMID: 23868316.
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    132. K(Ca)3.1 channel-blockade attenuates airway pathophysiology in a sheep model of chronic asthma. PLoS One. 2013; 8(6):e66886. Van Der Velden J, Sum G, Barker D, Koumoundouros E, Barcham G, Wulff H, Castle N, Bradding P, Snibson K. PMID: 23826167; PMCID: PMC3691218.
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    133. The intermediate conductance calcium-activated potassium channel KCa3.1 regulates vascular smooth muscle cell proliferation via controlling calcium-dependent signaling. J Biol Chem. 2013 May 31; 288(22):15843-53. Bi D, Toyama K, Lemaître V, Takai J, Fan F, Jenkins DP, Wulff H, Gutterman DD, Park F, Miura H. PMID: 23609438; PMCID: PMC3668741.
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    134. Ion channels. Thorax. 2013 Oct; 68(10):974-7. Bradding P, Wulff H. PMID: 23564342.
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    135. Novel phenolic inhibitors of small/intermediate-conductance Ca²⁺-activated K⁺ channels, KCa3.1 and KCa2.3. PLoS One. 2013; 8(3):e58614. Oliván-Viguera A, Valero MS, Murillo MD, Wulff H, García-Otín AL, Arbonés-Mainar JM, Köhler R. PMID: 23516517; PMCID: PMC3597730.
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    136. Endothelial small-conductance and intermediate-conductance KCa channels: an update on their pharmacology and usefulness as cardiovascular targets. J Cardiovasc Pharmacol. 2013 Feb; 61(2):102-12. Wulff H, Köhler R. PMID: 23107876; PMCID: PMC3565027.
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    137. The potassium channel KCa3.1 as new therapeutic target for the prevention of obliterative airway disease. Transplantation. 2013 Jan 27; 95(2):285-92. Hua X, Deuse T, Chen YJ, Wulff H, Stubbendorff M, Köhler R, Miura H, Länger F, Reichenspurner H, Robbins RC, Schrepfer S. PMID: 23325003; PMCID: PMC3777777.
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    138. NS6180, a new K(Ca) 3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease. Br J Pharmacol. 2013 Jan; 168(2):432-44. Strøbæk D, Brown DT, Jenkins DP, Chen YJ, Coleman N, Ando Y, Chiu P, Jørgensen S, Demnitz J, Wulff H, Christophersen P. PMID: 22891655; PMCID: PMC3572569.
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    139. A simple device to illustrate the Einthoven triangle. Adv Physiol Educ. 2012 Dec; 36(4):319-24. Jin BE, Wulff H, Widdicombe JH, Zheng J, Bers DM, Puglisi JL. PMID: 23209014; PMCID: PMC3776430.
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    140. Ca(2+)-activated K(+) channel-3.1 blocker TRAM-34 attenuates airway remodeling and eosinophilia in a murine asthma model. Am J Respir Cell Mol Biol. 2013 Feb; 48(2):212-9. Girodet PO, Ozier A, Carvalho G, Ilina O, Ousova O, Gadeau AP, Begueret H, Wulff H, Marthan R, Bradding P, Berger P. PMID: 23204391; PMCID: PMC4035224.
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    141. SKA-31, a novel activator of SK(Ca) and IK(Ca) channels, increases coronary flow in male and female rat hearts. Cardiovasc Res. 2013 Feb 01; 97(2):339-48. Mishra RC, Belke D, Wulff H, Braun AP. PMID: 23118129; PMCID: PMC3543990.
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    142. Genetic KCa3.1-deficiency produces locomotor hyperactivity and alterations in cerebral monoamine levels. PLoS One. 2012; 7(10):e47744. Lambertsen KL, Gramsbergen JB, Sivasaravanaparan M, Ditzel N, Sevelsted-Møller LM, Oliván-Viguera A, Rabjerg M, Wulff H, Köhler R. PMID: 23077667; PMCID: PMC3471871.
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    143. Structure-activity relationship exploration of Kv1.3 blockers based on diphenoxylate. Bioorg Med Chem Lett. 2012 Dec 01; 22(23):7106-9. Nguyen W, Howard BL, Jenkins DP, Wulff H, Thompson PE, Manallack DT. PMID: 23084278; PMCID: PMC3664202.
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    144. Triarylmethanes, a new class of cx50 inhibitors. Front Pharmacol. 2012; 3:106. Bodendiek SB, Rubinos C, Trelles MP, Coleman N, Jenkins DP, Wulff H, Srinivas M. PMID: 22685432; PMCID: PMC3368247.
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    145. Microglial KCa3.1 Channels as a Potential Therapeutic Target for Alzheimer's Disease. Int J Alzheimers Dis. 2012; 2012:868972. Maezawa I, Jenkins DP, Jin BE, Wulff H. PMID: 22675649; PMCID: PMC3364551.
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    146. Does microglial dysfunction play a role in autism and Rett syndrome? Neuron Glia Biol. 2011 Feb; 7(1):85-97. Maezawa I, Calafiore M, Wulff H, Jin LW. PMID: 22717189; PMCID: PMC4976478.
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    147. Purification, molecular cloning and functional characterization of HelaTx1 (Heterometrus laoticus): the first member of a new κ-KTX subfamily. Biochem Pharmacol. 2012 May 01; 83(9):1307-17. Vandendriessche T, Kopljar I, Jenkins DP, Diego-Garcia E, Abdel-Mottaleb Y, Vermassen E, Clynen E, Schoofs L, Wulff H, Snyders D, Tytgat J. PMID: 22305749; PMCID: PMC3644210.
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    148. Pharmacological activation of KCa3.1/KCa2.3 channels produces endothelial hyperpolarization and lowers blood pressure in conscious dogs. Br J Pharmacol. 2012 Jan; 165(1):223-34. Damkjaer M, Nielsen G, Bodendiek S, Staehr M, Gramsbergen JB, de Wit C, Jensen BL, Simonsen U, Bie P, Wulff H, Köhler R. PMID: 21699504; PMCID: PMC3252979.
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    149. The Lymphocyte Potassium Channels Kv1.3 and KCa3.1 as Targets for Immunosuppression. Drug Dev Res. 2011 Nov; 72(7):573-584. Lam J, Wulff H. PMID: 22241939; PMCID: PMC3253536.
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    150. Early changes in cerebellar physiology accompany motor dysfunction in the polyglutamine disease spinocerebellar ataxia type 3. J Neurosci. 2011 Sep 07; 31(36):13002-14. Shakkottai VG, do Carmo Costa M, Dell'Orco JM, Sankaranarayanan A, Wulff H, Paulson HL. PMID: 21900579; PMCID: PMC3170039.
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    151. Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases. Toxicon. 2012 Mar 15; 59(4):529-46. Chi V, Pennington MW, Norton RS, Tarcha EJ, Londono LM, Sims-Fahey B, Upadhyay SK, Lakey JT, Iadonato S, Wulff H, Beeton C, Chandy KG. PMID: 21867724; PMCID: PMC3397671.
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    152. The KCa3.1 blocker TRAM-34 reduces infarction and neurological deficit in a rat model of ischemia/reperfusion stroke. J Cereb Blood Flow Metab. 2011 Dec; 31(12):2363-74. Chen YJ, Raman G, Bodendiek S, O'Donnell ME, Wulff H. PMID: 21750563; PMCID: PMC3323185.
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    153. Negative gating modulation by (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine (NS8593) depends on residues in the inner pore vestibule: pharmacological evidence of deep-pore gating of K(Ca)2 channels. Mol Pharmacol. 2011 Jun; 79(6):899-909. Jenkins DP, Strøbæk D, Hougaard C, Jensen ML, Hummel R, Sørensen US, Christophersen P, Wulff H. PMID: 21363929; PMCID: PMC3102549.
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    154. Improvement of endothelium-dependent vasodilations by SKA-31 and SKA-20, activators of small- and intermediate-conductance Ca2+ -activated K+ -channels. Acta Physiol (Oxf). 2011 Sep; 203(1):117-26. Hasenau AL, Nielsen G, Morisseau C, Hammock BD, Wulff H, Köhler R. PMID: 21362152; PMCID: PMC3139805.
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    155. Identification of phase-I metabolites and chronic toxicity study of the Kv1.3 blocker PAP-1 (5-(4-phenoxybutoxy)psoralen) in the rat. Xenobiotica. 2011 Mar; 41(3):198-211. Hao B, Chen ZW, Zhou XJ, Zimin PI, Miljanich GP, Wulff H, Wang YX. PMID: 21070145; PMCID: PMC3644211.
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    156. Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity. J Biol Chem. 2011 Feb 04; 286(5):3693-706. Maezawa I, Zimin PI, Wulff H, Jin LW. PMID: 20971854; PMCID: PMC3030372.
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    157. Spiro azepane-oxazolidinones as Kv1.3 potassium channel blockers: WO2010066840. Expert Opin Ther Pat. 2010 Dec; 20(12):1759-65. Wulff H. PMID: 20954790; PMCID: PMC2988097.
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    158. Potassium channel block by a tripartite complex of two cationophilic ligands and a potassium ion. Mol Pharmacol. 2010 Oct; 78(4):588-99. Zimin PI, Garic B, Bodendiek SB, Mahieux C, Wulff H, Zhorov BS. PMID: 20601455; PMCID: PMC2981387.
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    159. Therapeutic potential of KCa3.1 blockers: recent advances and promising trends. Expert Rev Clin Pharmacol. 2010 May; 3(3):385-96. Wulff H, Castle NA. PMID: 22111618; PMCID: PMC3347644.
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    160. Formulation-based approach to support early drug discovery and development efforts: a case study with enteric microencapsulation dosage form development for a triarylmethane derivative TRAM-34; a novel potential immunosuppressant. Drug Dev Ind Pharm. 2010 May; 36(5):563-9. Al-Ghananeem AM, Abbassi M, Shrestha S, Raman G, Wulff H, Pereira L, Ansari A. PMID: 19929567; PMCID: PMC3337761.
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    161. Vascular KCa-channels as therapeutic targets in hypertension and restenosis disease. Expert Opin Ther Targets. 2010 Feb; 14(2):143-55. Köhler R, Kaistha BP, Wulff H. PMID: 20055714; PMCID: PMC3644209.
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    162. Inhibition of the K+ channel KCa3.1 ameliorates T cell-mediated colitis. Proc Natl Acad Sci U S A. 2010 Jan 26; 107(4):1541-6. Di L, Srivastava S, Zhdanova O, Ding Y, Li Z, Wulff H, Lafaille M, Skolnik EY. PMID: 20080610; PMCID: PMC2824388.
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    163. Use of Kv1.3 blockers for inflammatory skin conditions. Curr Med Chem. 2010; 17(26):2882-96. Nguyen W, Howard BL, Neale DS, Thompson PE, White PJ, Wulff H, Manallack DT. PMID: 20858170; PMCID: PMC3337760.
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    164. Voltage-gated potassium channels as therapeutic targets. Nat Rev Drug Discov. 2009 Dec; 8(12):982-1001. Wulff H, Castle NA, Pardo LA. PMID: 19949402; PMCID: PMC2790170.
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    165. Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14518-23. Grgic I, Kiss E, Kaistha BP, Busch C, Kloss M, Sautter J, Müller A, Kaistha A, Schmidt C, Raman G, Wulff H, Strutz F, Gröne HJ, Köhler R, Hoyer J. PMID: 19706538; PMCID: PMC2726862.
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    166. The K+ channels K(Ca)3.1 and K(v)1.3 as novel targets for asthma therapy. Br J Pharmacol. 2009 Aug; 157(8):1330-9. Bradding P, Wulff H. PMID: 19681865; PMCID: PMC2765317.
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    167. The class II phosphatidylinositol 3 kinase C2beta is required for the activation of the K+ channel KCa3.1 and CD4 T-cells. Mol Biol Cell. 2009 Sep; 20(17):3783-91. Srivastava S, Di L, Zhdanova O, Li Z, Vardhana S, Wan Q, Yan Y, Varma R, Backer J, Wulff H, Dustin ML, Skolnik EY. PMID: 19587117; PMCID: PMC2735477.
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    168. Blockade of T-lymphocyte KCa3.1 and Kv1.3 channels as novel immunosuppression strategy to prevent kidney allograft rejection. Transplant Proc. 2009 Jul-Aug; 41(6):2601-6. Grgic I, Wulff H, Eichler I, Flothmann C, Köhler R, Hoyer J. PMID: 19715983; PMCID: PMC3343637.
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    169. Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension. Circulation. 2009 May 05; 119(17):2323-32. Brähler S, Kaistha A, Schmidt VJ, Wölfle SE, Busch C, Kaistha BP, Kacik M, Hasenau AL, Grgic I, Si H, Bond CT, Adelman JP, Wulff H, de Wit C, Hoyer J, Köhler R. PMID: 19380617.
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    170. 4-Phenoxybutoxy-substituted heterocycles--a structure-activity relationship study of blockers of the lymphocyte potassium channel Kv1.3. Eur J Med Chem. 2009 May; 44(5):1838-52. Bodendiek SB, Mahieux C, Hänsel W, Wulff H. PMID: 19056148; PMCID: PMC2662044.
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    171. Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure. Mol Pharmacol. 2009 Feb; 75(2):281-95. Sankaranarayanan A, Raman G, Busch C, Schultz T, Zimin PI, Hoyer J, Köhler R, Wulff H. PMID: 18955585; PMCID: PMC2635097.
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    172. Protein histidine phosphatase 1 negatively regulates CD4 T cells by inhibiting the K+ channel KCa3.1. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14442-6. Srivastava S, Zhdanova O, Di L, Li Z, Albaqumi M, Wulff H, Skolnik EY. PMID: 18796614; PMCID: PMC2538450.
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    173. The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. J Clin Invest. 2008 Sep; 118(9):3025-37. Toyama K, Wulff H, Chandy KG, Azam P, Raman G, Saito T, Fujiwara Y, Mattson DL, Das S, Melvin JE, Pratt PF, Hatoum OA, Gutterman DD, Harder DR, Miura H. PMID: 18688283; PMCID: PMC2496961.
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    174. New light on the "old" chloride channel blocker DIDS. ACS Chem Biol. 2008 Jul 18; 3(7):399-401. Wulff H. PMID: 18642798.
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    175. KCa3.1 potassium channels are critical for cAMP-dependent chloride secretion and cyst growth in autosomal-dominant polycystic kidney disease. Kidney Int. 2008 Sep; 74(6):740-9. Albaqumi M, Srivastava S, Li Z, Zhdnova O, Wulff H, Itani O, Wallace DP, Skolnik EY. PMID: 18547995.
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    176. K+ channel modulators for the treatment of neurological disorders and autoimmune diseases. Chem Rev. 2008 May; 108(5):1744-73. Wulff H, Zhorov BS. PMID: 18476673; PMCID: PMC2714671.
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    177. Local delivery of the KCa3.1 blocker, TRAM-34, prevents acute angioplasty-induced coronary smooth muscle phenotypic modulation and limits stenosis. Arterioscler Thromb Vasc Biol. 2008 Jun; 28(6):1084-9. Tharp DL, Wamhoff BR, Wulff H, Raman G, Cheong A, Bowles DK. PMID: 18309114; PMCID: PMC2652246.
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    178. Pharmacokinetics, toxicity, and functional studies of the selective Kv1.3 channel blocker 5-(4-phenoxybutoxy)psoralen in rhesus macaques. Exp Biol Med (Maywood). 2007 Nov; 232(10):1338-54. Pereira LE, Villinger F, Wulff H, Sankaranarayanan A, Raman G, Ansari AA. PMID: 17959847; PMCID: PMC2390884.
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    179. Targeting effector memory T-cells with Kv1.3 blockers. Curr Opin Drug Discov Devel. 2007 Jul; 10(4):438-45. Wulff H, Pennington M. PMID: 17659485.
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    180. Targeting effector memory T cells with the small molecule Kv1.3 blocker PAP-1 suppresses allergic contact dermatitis. J Invest Dermatol. 2007 Jun; 127(6):1419-29. Azam P, Sankaranarayanan A, Homerick D, Griffey S, Wulff H. PMID: 17273162; PMCID: PMC1929164.
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    181. AMA production in primary biliary cirrhosis is promoted by the TLR9 ligand CpG and suppressed by potassium channel blockers. Hepatology. 2007 Feb; 45(2):314-22. Moritoki Y, Lian ZX, Wulff H, Yang GX, Chuang YH, Lan RY, Ueno Y, Ansari AA, Coppel RL, Mackay IR, Gershwin ME. PMID: 17256753.
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    183. Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17414-9. Beeton C, Wulff H, Standifer NE, Azam P, Mullen KM, Pennington MW, Kolski-Andreaco A, Wei E, Grino A, Counts DR, Wang PH, LeeHealey CJ, S Andrews B, Sankaranarayanan A, Homerick D, Roeck WW, Tehranzadeh J, Stanhope KL, Zimin P, Havel PJ, Griffey S, Knaus HG, Nepom GT, Gutman GA, Calabresi PA, Chandy KG. PMID: 17088564; PMCID: PMC1859943.
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    184. A new class of blockers of the voltage-gated potassium channel Kv1.3 via modification of the 4- or 7-position of khellinone. J Med Chem. 2006 Feb 23; 49(4):1433-41. Harvey AJ, Baell JB, Toovey N, Homerick D, Wulff H. PMID: 16480279.
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    185. Kv1.3 Potassium Channel: Physiology, Pharmacology and Therapeutic Indications. . 2006 Feb 6; 29:214-274. Chandy CK, Wulff WH, Beeton BC, Calabresi CP, Gutman GG, Pennington PM. .
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    186. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. Pharmacol Rev. 2005 Dec; 57(4):463-72. Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H. PMID: 16382103.
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    187. Pharmacological profiling of Orthochirus scrobiculosus toxin 1 analogs with a trimmed N-terminal domain. Mol Pharmacol. 2006 Jan; 69(1):354-62. Mouhat S, Teodorescu G, Homerick D, Visan V, Wulff H, Wu Y, Grissmer S, Darbon H, De Waard M, Sabatier JM. PMID: 16234482.
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    188. Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases. Mol Pharmacol. 2005 Nov; 68(5):1254-70. Schmitz A, Sankaranarayanan A, Azam P, Schmidt-Lassen K, Homerick D, Hänsel W, Wulff H. PMID: 16099841.
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    189. The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain. Proc Natl Acad Sci U S A. 2005 Aug 02; 102(31):11094-9. Rus H, Pardo CA, Hu L, Darrah E, Cudrici C, Niculescu T, Niculescu F, Mullen KM, Allie R, Guo L, Wulff H, Beeton C, Judge SI, Kerr DA, Knaus HG, Chandy KG, Calabresi PA. PMID: 16043714; PMCID: PMC1182417.
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    190. Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases. Mol Pharmacol. 2005 Apr; 67(4):1369-81. Beeton C, Pennington MW, Wulff H, Singh S, Nugent D, Crossley G, Khaytin I, Calabresi PA, Chen CY, Gutman GA, Chandy KG. PMID: 15665253; PMCID: PMC4275123.
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    191. K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom. Biochem J. 2005 Jan 01; 385(Pt 1):95-104. Mouhat S, Visan V, Ananthakrishnan S, Wulff H, Andreotti N, Grissmer S, Darbon H, De Waard M, Sabatier JM. PMID: 15588251; PMCID: PMC1134677.
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    192. Potassium channel blockade by the sea anemone toxin ShK for the treatment of multiple sclerosis and other autoimmune diseases. Curr Med Chem. 2004 Dec; 11(23):3041-52. Norton RS, Pennington MW, Wulff H. PMID: 15578998.
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    193. K+ channel expression during B cell differentiation: implications for immunomodulation and autoimmunity. J Immunol. 2004 Jul 15; 173(2):776-86. Wulff H, Knaus HG, Pennington M, Chandy KG. PMID: 15240664.
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    194. Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. Mol Pharmacol. 2004 Jun; 65(6):1364-74. Vennekamp J, Wulff H, Beeton C, Calabresi PA, Grissmer S, Hänsel W, Chandy KG. PMID: 15155830.
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    195. K+ channels as targets for specific immunomodulation. Trends Pharmacol Sci. 2004 May; 25(5):280-9. Chandy KG, Wulff H, Beeton C, Pennington M, Gutman GA, Cahalan MD. PMID: 15120495; PMCID: PMC2749963.
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    196. Khellinone derivatives as blockers of the voltage-gated potassium channel Kv1.3: synthesis and immunosuppressive activity. J Med Chem. 2004 Apr 22; 47(9):2326-36. Baell JB, Gable RW, Harvey AJ, Toovey N, Herzog T, Hänsel W, Wulff H. PMID: 15084131.
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    197. The 'functional' dyad of scorpion toxin Pi1 is not itself a prerequisite for toxin binding to the voltage-gated Kv1.2 potassium channels. Biochem J. 2004 Jan 01; 377(Pt 1):25-36. Mouhat S, Mosbah A, Visan V, Wulff H, Delepierre M, Darbon H, Grissmer S, De Waard M, Sabatier JM. PMID: 12962541; PMCID: PMC1223833.
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    198. International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev. 2003 Dec; 55(4):583-6. Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M, Lesage F, Lester HA, McKinnon D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M, Seino S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, Wymore RS, International Union of Pharmacology. PMID: 14657415.
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    199. Potassium channels as therapeutic targets for autoimmune disorders. Curr Opin Drug Discov Devel. 2003 Sep; 6(5):640-7. Wulff H, Beeton C, Chandy KG. PMID: 14579513.
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    200. Blockade of the intermediate-conductance calcium-activated potassium channel as a new therapeutic strategy for restenosis. Circulation. 2003 Sep 02; 108(9):1119-25. Köhler R, Wulff H, Eichler I, Kneifel M, Neumann D, Knorr A, Grgic I, Kämpfe D, Si H, Wibawa J, Real R, Borner K, Brakemeier S, Orzechowski HD, Reusch HP, Paul M, Chandy KG, Hoyer J. PMID: 12939222.
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    201. The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS. J Clin Invest. 2003 Jun; 111(11):1703-13. Wulff H, Calabresi PA, Allie R, Yun S, Pennington M, Beeton C, Chandy KG. PMID: 12782673; PMCID: PMC156104.
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    202. A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes. J Biol Chem. 2003 Mar 14; 278(11):9928-37. Beeton C, Wulff H, Singh S, Botsko S, Crossley G, Gutman GA, Cahalan MD, Pennington M, Chandy KG. PMID: 12511563.
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    203. Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI). Eur J Hum Genet. 2002 Jan; 10(1):36-43. Bardien-Kruger S, Wulff H, Arieff Z, Brink P, Chandy KG, Corfield V. PMID: 11896454.
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    204. Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. J Biol Chem. 2002 Feb 01; 277(5):3793-800. Ayabe T, Wulff H, Darmoul D, Cahalan MD, Chandy KG, Ouellette AJ. PMID: 11724775.
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    205. Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24):13942-7. Beeton C, Wulff H, Barbaria J, Clot-Faybesse O, Pennington M, Bernard D, Cahalan MD, Chandy KG, Béraud E. PMID: 11717451; PMCID: PMC61146.
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    206. Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants. Toxicon. 2001 Sep; 39(9):1269-76. Chandy KG, Cahalan M, Pennington M, Norton RS, Wulff H, Gutman GA. PMID: 11384714.
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    207. Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2. J Biol Chem. 2001 Nov 16; 276(46):43145-51. Shakkottai VG, Regaya I, Wulff H, Fajloun Z, Tomita H, Fathallah M, Cahalan MD, Gargus JJ, Sabatier JM, Chandy KG. PMID: 11527975.
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    208. Molecular properties and physiological roles of ion channels in the immune system. J Clin Immunol. 2001 Jul; 21(4):235-52. Cahalan MD, Wulff H, Chandy KG. PMID: 11506193.
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    209. Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1. J Biol Chem. 2001 Aug 24; 276(34):32040-5. Wulff H, Gutman GA, Cahalan MD, Chandy KG. PMID: 11425865.
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    210. Gallamine triethiodide selectively blocks voltage-gated potassium channels in Ranvier nodes. Gen Physiol Biophys. 2001 Mar; 20(1):83-95. Hinck D, Wulff H, Koppenhöfer E. PMID: 11508824.
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    211. Calcium-activated potassium channels sustain calcium signaling in T lymphocytes. Selective blockers and manipulated channel expression levels. J Biol Chem. 2001 Apr 13; 276(15):12249-56. Fanger CM, Rauer H, Neben AL, Miller MJ, Rauer H, Wulff H, Rosa JC, Ganellin CR, Chandy KG, Cahalan MD. PMID: 11278890.
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    212. Effects of three alkoxypsoralens on voltage gated ion channels in Ranvier nodes. Gen Physiol Biophys. 2000 Dec; 19(4):345-64. Düring T, Gerst F, Hänsel W, Wulff H, Koppenhöfer E. PMID: 11409838.
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    213. Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences. J Biol Chem. 2000 Nov 24; 275(47):37137-49. Ghanshani S, Wulff H, Miller MJ, Rohm H, Neben A, Gutman GA, Cahalan MD, Chandy KG. PMID: 10961988.
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    214. Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc Natl Acad Sci U S A. 2000 07 05; 97(14):8151-6. Wulff H, Miller MJ, Hansel W, Grissmer S, Cahalan MD, Chandy KG. PMID: 10884437; PMCID: PMC16685.
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    215. K(+) channel-blocking alkoxypsoralens inhibit the immune response of encephalitogenic T line cells and lymphocytes from Lewis rats challenged for experimental autoimmune encephalomyelitis. Immunopharmacology. 2000 Jun; 48(1):51-63. Strauss U, Wissel K, Jung S, Wulff H, Hänsel W, Zhu J, Rolfs A, Mix E. PMID: 10822089.
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    216. Alkoxypsoralens, novel nonpeptide blockers of Shaker-type K+ channels: synthesis and photoreactivity. J Med Chem. 1998 Nov 05; 41(23):4542-9. Wulff H, Rauer H, Düring T, Hanselmann C, Ruff K, Wrisch A, Grissmer S, Hänsel W. PMID: 9804693.
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