Heike Wulff

Title(s)Professor, Pharmacology
SchoolUniversity of California, Davis
Address3513 GBSF
CA 95616
Phone530-754-6135
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    Collapse Research 
    Collapse Research Activities and Funding
    The Role of KCa3.1 in Microglial function and in Parkinsons disease pathogenesis
    NIH R01NS124226Jul 15, 2021 - Apr 30, 2026
    Role: Co-Principal Investigator
    Optimization of non-addictive biologics to target sodium channels involved in pain signaling
    NIH UG3NS114956Sep 30, 2019 - Aug 31, 2021
    Role: Co-Principal Investigator
    Identifying Molecular Targets for the Proconvulsant Activity of TETS
    NIH R21NS110647Jul 1, 2019 - Jun 30, 2021
    Role: Co-Principal Investigator
    Microglial K+ Channels in Ischemic Stroke
    NIH R01NS100294May 1, 2017 - Feb 28, 2021
    Role: Principal Investigator
    Structure Assisted Design of SK Channel Selective Activators
    NIH R21NS101876Feb 1, 2017 - Jul 31, 2020
    Role: Principal Investigator
    Optimization of KCa2 Channel Activators as Neuroscience Tools and Potential Drugs
    NIH R21NS072585Aug 1, 2011 - May 31, 2014
    Role: Principal Investigator
    The Microglial Kv1.3 Channel in Alzheimer's Disease
    NIH R21AG038910Aug 1, 2011 - Jun 30, 2013
    Role: Co-Principal Investigator
    Design of Slack Channel Activators
    NIH R21NS073943Apr 1, 2011 - Mar 31, 2013
    Role: Co-Principal Investigator
    Microglial Potassium Channels in Ischemic Stroke
    NIH R56NS098328Jul 1, 2006 - Jul 31, 2018
    Role: Principal Investigator
    The microglial potassium channels Kv1.3 and KCa3.1 as therapeutic targets for neu
    NIH R01GM076063Jul 1, 2006 - Jun 30, 2016
    Role: Principal Investigator
    Small Molecule Kv1.3 Blockers as New Therapeutics for Multiple Sclerosis
    NIH R21NS053426Jan 1, 2006 - Jun 30, 2008
    Role: Principal Investigator
    SK Channel Openers as Therapeutics for Cerebellar Ataxia
    NIH R21NS052165Jul 15, 2005 - Apr 30, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Effects of TRAM-34 and minocycline on neuroinflammation caused by diabetic ketoacidosis in a rat model. BMJ Open Diabetes Res Care. 2022 May; 10(3). Glaser N, Chu S, Weiner J, Zdepski L, Wulff H, Tancredi D, ODonnell ME. PMID: 35584854.
      View in: PubMed   Mentions:
    2. Discovery of novel activators of large-conductance calcium-activated potassium channels for the treatment of cerebellar ataxia. Mol Pharmacol. 2022 Apr 30. Srinivasan SR, Huang H, Chang WC, Nasburg JA, Nguyen HM, Strassmaier T, Wulff H, Shakkottai VG. PMID: 35489717.
      View in: PubMed   Mentions:
    3. Pose Classification Using Three-Dimensional Atomic Structure-Based Neural Networks Applied to Ion Channel-Ligand Docking. J Chem Inf Model. 2022 Apr 21. Shim H, Kim H, Allen JE, Wulff H. PMID: 35447030.
      View in: PubMed   Mentions:
    4. Muscle Damage in Dystrophic mdx Mice Is Influenced by the Activity of Ca2+-Activated KCa3.1 Channels. Life (Basel). 2022 Apr 05; 12(4). Morotti M, Garofalo S, Cocozza G, Antonangeli F, Bianconi V, Mozzetta C, De Stefano ME, Capitani R, Wulff H, Limatola C, Catalano M, Grassi F. PMID: 35455028; PMCID: PMC9025295.
      View in: PubMed   Mentions:
    5. The seizure-inducing plastic explosive RDX inhibits the α1β2γ2 GABAA receptor. Ann Clin Transl Neurol. 2022 May; 9(5):600-609. Pressly B, Lee RD, Singh V, Pessah IN, Wulff H. PMID: 35324073; PMCID: PMC9082378.
      View in: PubMed   Mentions:
    6. Channelopathy-causing mutations in the S45A/S45B and HA/HB helices of KCa2.3 and KCa3.1 channels alter their apparent Ca2+ sensitivity. Cell Calcium. 2022 03; 102:102538. Orfali R, Nam YW, Nguyen HM, Rahman MA, Yang G, Cui M, Wulff H, Zhang M. PMID: 35030515; PMCID: PMC8844225.
      View in: PubMed   Mentions:
    7. Structure-Activity Relationship Study of Subtype-Selective Positive Modulators of KCa2 Channels. J Med Chem. 2022 01 13; 65(1):303-322. El-Sayed NS, Nam YW, Egorova PA, Nguyen HM, Orfali R, Rahman MA, Yang G, Wulff H, Bezprozvanny I, Parang K, Zhang M. PMID: 34962403; PMCID: PMC8758555.
      View in: PubMed   Mentions:
    8. Kv1.3 inhibition attenuates neuroinflammation through disruption of microglial calcium signaling. Channels (Austin). 2021 12; 15(1):67-78. Fomina AF, Nguyen HM, Wulff H. PMID: 33356832; PMCID: PMC7781540.
      View in: PubMed   Mentions: 2     Fields:    
    9. The potassium channel Kv1.3 as a therapeutic target for immunocytoprotection after reperfusion. Ann Clin Transl Neurol. 2021 10; 8(10):2070-2082. Chen YJ, Cui Y, Singh L, Wulff H. PMID: 34617690; PMCID: PMC8528456.
      View in: PubMed   Mentions:    Fields:    
    10. The feeding behaviour of Amyotrophic Lateral Sclerosis mouse models is modulated by the Ca2+ -activated KCa 3.1 channels. Br J Pharmacol. 2021 12; 178(24):4891-4906. Cocozza G, Garofalo S, Morotti M, Chece G, Grimaldi A, Lecce M, Scavizzi F, Menghini R, Casagrande V, Federici M, Raspa M, Wulff H, Limatola C. PMID: 34411281.
      View in: PubMed   Mentions:    Fields:    
    11. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels. Br J Pharmacol. 2021 Oct; 178 Suppl 1:S157-S245. Alexander SP, Mathie A, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Aldrich RW, Attali B, Baggetta AM, Becirovic E, Biel M, Bill RM, Catterall WA, Conner AC, Davies P, Delling M, Virgilio FD, Falzoni S, Fenske S, George C, Goldstein SAN, Grissmer S, Ha K, Hammelmann V, Hanukoglu I, Jarvis M, Jensen AA, Kaczmarek LK, Kellenberger S, Kennedy C, King B, Kitchen P, Lynch JW, Perez-Reyes E, Plant LD, Rash L, Ren D, Salman MM, Sivilotti LG, Smart TG, Snutch TP, Tian J, Trimmer JS, Van den Eynde C, Vriens J, Wei AD, Winn BT, Wulff H, Xu H, Yue L, Zhang X, Zhu M. PMID: 34529831.
      View in: PubMed   Mentions:    Fields:    
    12. The efficacy of γ-aminobutyric acid type A receptor (GABA AR) subtype-selective positive allosteric modulators in blocking tetramethylenedisulfotetramine (TETS)-induced seizure-like behavior in larval zebrafish with minimal sedation. Toxicol Appl Pharmacol. 2021 09 01; 426:115643. Mundy PC, Pressly B, Carty DR, Yaghoobi B, Wulff H, Lein PJ. PMID: 34265354; PMCID: PMC8514104.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    13. Molecular determinants of pro-arrhythmia proclivity of d- and l-sotalol via a multi-scale modeling pipeline. J Mol Cell Cardiol. 2021 09; 158:163-177. DeMarco KR, Yang PC, Singh V, Furutani K, Dawson JRD, Jeng MT, Fettinger JC, Bekker S, Ngo VA, Noskov SY, Yarov-Yarovoy V, Sack JT, Wulff H, Clancy CE, Vorobyov I. PMID: 34062207; PMCID: PMC8906354.
      View in: PubMed   Mentions:    Fields:    
    14. Editorial: Venoms, Animal and Microbial Toxins. Front Pharmacol. 2021; 12:706573. Cao Z, Wang JL, McNutt PM, Utkin YN, Shahbazzadeh D, Wulff H, Kovacic H, Sabatier JM. PMID: 34122121; PMCID: PMC8188234.
      View in: PubMed   Mentions:
    15. Structure-Activity Relationship of Neuroactive Steroids, Midazolam, and Perampanel Toward Mitigating Tetramine-Triggered Activity in Murine Hippocampal Neuronal Networks. Toxicol Sci. 2021 04 12; 180(2):325-341. Antrobus S, Pressly B, Nik AM, Wulff H, Pessah IN. PMID: 33483729; PMCID: PMC8599726.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    16. Unique molecular characteristics and microglial origin of Kv1.3 channel-positive brain myeloid cells in Alzheimer's disease. Proc Natl Acad Sci U S A. 2021 03 16; 118(11). Ramesha S, Rayaprolu S, Bowen CA, Giver CR, Bitarafan S, Nguyen HM, Gao T, Chen MJ, Nwabueze N, Dammer EB, Engstrom AK, Xiao H, Pennati A, Seyfried NT, Katz DJ, Galipeau J, Wulff H, Waller EK, Wood LB, Levey AI, Rangaraju S. PMID: 33649184; PMCID: PMC7980378.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    17. ATP-evoked intracellular Ca2+ transients shape the ionic permeability of human microglia from epileptic temporal cortex. J Neuroinflammation. 2021 Feb 15; 18(1):44. Palomba NP, Martinello K, Cocozza G, Casciato S, Mascia A, Di Gennaro G, Morace R, Esposito V, Wulff H, Limatola C, Fucile S. PMID: 33588880; PMCID: PMC7883449.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    18. A non-hallucinogenic psychedelic analogue with therapeutic potential. Nature. 2021 01; 589(7842):474-479. Cameron LP, Tombari RJ, Lu J, Pell AJ, Hurley ZQ, Ehinger Y, Vargas MV, McCarroll MN, Taylor JC, Myers-Turnbull D, Liu T, Yaghoobi B, Laskowski LJ, Anderson EI, Zhang G, Viswanathan J, Brown BM, Tjia M, Dunlap LE, Rabow ZT, Fiehn O, Wulff H, McCorvy JD, Lein PJ, Kokel D, Ron D, Peters J, Zuo Y, Olson DE. PMID: 33299186; PMCID: PMC7874389.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    19. Acute and chronic neuroinflammation is triggered by diabetic ketoacidosis in a rat model. BMJ Open Diabetes Res Care. 2020 12; 8(2). Glaser N, Chu S, Hung B, Fernandez L, Wulff H, Tancredi D, ODonnell ME. PMID: 33318070; PMCID: PMC7737057.
      View in: PubMed   Mentions: Translation:HumansAnimals
    20. New capsaicin analogs as molecular rulers to define the permissive conformation of the mouse TRPV1 ligand-binding pocket. Elife. 2020 11 09; 9. Vu S, Singh V, Wulff H, Yarov-Yarovoy V, Zheng J. PMID: 33164749; PMCID: PMC7671684.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    21. Identification of the Functional Binding Site for the Convulsant Tetramethylenedisulfotetramine in the Pore of the α2β3γ2 GABAA Receptor. Mol Pharmacol. 2021 01; 99(1):78-91. Pressly B, Lee RD, Barnych B, Hammock BD, Wulff H. PMID: 33109687; PMCID: PMC7746976.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    22. KCa channel activation normalizes endothelial function in Type 2 Diabetic resistance arteries by improving intracellular Ca2+ mobilization. Metabolism. 2021 01; 114:154390. Mishra RC, Kyle BD, Kendrick DJ, Svystonyuk D, Kieser TM, Fedak PWM, Wulff H, Braun AP. PMID: 33039407; PMCID: PMC7736096.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    23. Acute administration of diazepam or midazolam minimally alters long-term neuropathological effects in the rat brain following acute intoxication with diisopropylfluorophosphate. Eur J Pharmacol. 2020 Nov 05; 886:173538. Supasai S, González EA, Rowland DJ, Hobson B, Bruun DA, Guignet MA, Soares S, Singh V, Wulff H, Saito N, Harvey DJ, Lein PJ. PMID: 32898549; PMCID: PMC7572820.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    24. Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease. J Clin Invest. 2020 08 03; 130(8):4195-4212. Sarkar S, Nguyen HM, Malovic E, Luo J, Langley M, Palanisamy BN, Singh N, Manne S, Neal M, Gabrielle M, Abdalla A, Anantharam P, Rokad D, Panicker N, Singh V, Ay M, Charli A, Harischandra D, Jin LW, Jin H, Rangaraju S, Anantharam V, Wulff H, Kanthasamy AG. PMID: 32597830; PMCID: PMC7410064.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    25. Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice. Br J Anaesth. 2020 09; 125(3):298-307. Lai IK, Valdearcos M, Morioka K, Saxena S, Feng X, Li R, Uchida Y, Lijun A, Li W, Pan J, Koliwad S, Marcucio R, Wulff H, Maze M. PMID: 32624183; PMCID: PMC7497028.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    26. Biophysical basis for Kv1.3 regulation of membrane potential changes induced by P2X4-mediated calcium entry in microglia. Glia. 2020 11; 68(11):2377-2394. Nguyen HM, di Lucente J, Chen YJ, Cui Y, Ibrahim RH, Pennington MW, Jin LW, Maezawa I, Wulff H. PMID: 32525239; PMCID: PMC7540709.
      View in: PubMed   Mentions: 9     Fields:    
    27. Modulation of Lymphocyte Potassium Channel KV1.3 by Membrane-Penetrating, Joint-Targeting Immunomodulatory Plant Defensin. ACS Pharmacol Transl Sci. 2020 Aug 14; 3(4):720-736. Ong ST, Bajaj S, Tanner MR, Chang SC, Krishnarjuna B, Ng XR, Morales RAV, Chen MW, Luo D, Patel D, Yasmin S, Ng JJH, Zhuang Z, Nguyen HM, El Sahili A, Lescar J, Patil R, Charman SA, Robins EG, Goggi JL, Tan PW, Sadasivam P, Ramasamy B, Hartimath SV, Dhawan V, Bednenko J, Colussi P, Wulff H, Pennington MW, Kuyucak S, Norton RS, Beeton C, Chandy KG. PMID: 32832873; PMCID: PMC7432667.
      View in: PubMed   Mentions:
    28. Comparison of the toxicokinetics of the convulsants picrotoxinin and tetramethylenedisulfotetramine (TETS) in mice. Arch Toxicol. 2020 06; 94(6):1995-2007. Pressly B, Vasylieva N, Barnych B, Singh V, Singh L, Bruun DA, Hwang SH, Chen YJ, Fettinger JC, Johnnides S, Lein PJ, Yang J, Hammock BD, Wulff H. PMID: 32239239; PMCID: PMC7303059.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    29. Conditional KCa3.1-transgene induction in murine skin produces pruritic eczematous dermatitis with severe epidermal hyperplasia and hyperkeratosis. PLoS One. 2020; 15(3):e0222619. Lozano-Gerona J, Oliván-Viguera A, Delgado-Wicke P, Singh V, Brown BM, Tapia-Casellas E, Pueyo E, Valero MS, Garcia-Otín ÁL, Giraldo P, Abarca-Lachen E, Surra JC, Osada J, Hamilton KL, Raychaudhuri SP, Marigil M, Juarranz Á, Wulff H, Miura H, Gilaberte Y, Köhler R. PMID: 32150577; PMCID: PMC7062274.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    30. Susceptibility of larval zebrafish to the seizurogenic activity of GABA type A receptor antagonists. Neurotoxicology. 2020 01; 76:220-234. Bandara SB, Carty DR, Singh V, Harvey DJ, Vasylieva N, Pressly B, Wulff H, Lein PJ. PMID: 31811871; PMCID: PMC6957304.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    31. SKA-31, an activator of Ca2+-activated K+ channels, improves cardiovascular function in aging. Pharmacol Res. 2020 01; 151:104539. John CM, Khaddaj Mallat R, Mishra RC, George G, Singh V, Turnbull JD, Umeshappa CS, Kendrick DJ, Kim T, Fauzi FM, Visser F, Fedak PWM, Wulff H, Braun AP. PMID: 31707036; PMCID: PMC6956598.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    32. The Trials and Tribulations of Structure Assisted Design of KCa Channel Activators. Front Pharmacol. 2019; 10:972. Shim H, Brown BM, Singh L, Singh V, Fettinger JC, Yarov-Yarovoy V, Wulff H. PMID: 31616290; PMCID: PMC6764326.
      View in: PubMed   Mentions: 2  
    33. Extracellular K+ Dampens T Cell Functions: Implications for Immune Suppression in the Tumor Microenvironment. Bioelectricity. 2019 Sep 01; 1(3):169-179. Ong ST, Ng AS, Ng XR, Zhuang Z, Wong BHS, Prasannan P, Kok YJ, Bi X, Shim H, Wulff H, Chandy KG, Verma NK. PMID: 34471819; PMCID: PMC8370284.
      View in: PubMed   Mentions:
    34. Pharmacology of Small- and Intermediate-Conductance Calcium-Activated Potassium Channels. Annu Rev Pharmacol Toxicol. 2020 01 06; 60:219-240. Brown BM, Shim H, Christophersen P, Wulff H. PMID: 31337271.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    35. Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 05; 18(5):339-357. Wulff H, Christophersen P, Colussi P, Chandy KG, Yarov-Yarovoy V. PMID: 30728472; PMCID: PMC6499689.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    36. Repurposing the KCa3.1 inhibitor senicapoc for Alzheimer's disease. Ann Clin Transl Neurol. 2019 Apr; 6(4):723-738. Jin LW, Lucente JD, Nguyen HM, Singh V, Singh L, Chavez M, Bushong T, Wulff H, Maezawa I. PMID: 31019997; PMCID: PMC6469250.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    37. Radiation Increases Functional KCa3.1 Expression and Invasiveness in Glioblastoma. Cancers (Basel). 2019 Feb 26; 11(3). D'Alessandro G, Monaco L, Catacuzzeno L, Antonangeli F, Santoro A, Esposito V, Franciolini F, Wulff H, Limatola C. PMID: 30813636; PMCID: PMC6468446.
      View in: PubMed   Mentions: 4  
    38. Recent advances in our understanding of the structure and function of more unusual cation channels. F1000Res. 2019; 8. Brown BM, Nguyen HM, Wulff H. PMID: 30755796; PMCID: PMC6354322.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    39. The voltage-gated potassium channel Kv1.3 is required for microglial pro-inflammatory activation in vivo. Glia. 2018 09; 66(9):1881-1895. Di Lucente J, Nguyen HM, Wulff H, Jin LW, Maezawa I. PMID: 30043400; PMCID: PMC6185766.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    40. Ca2+-activated K+ channels modulate microglia affecting motor neuron survival in hSOD1G93A mice. Brain Behav Immun. 2018 10; 73:584-595. Cocozza G, di Castro MA, Carbonari L, Grimaldi A, Antonangeli F, Garofalo S, Porzia A, Madonna M, Mainiero F, Santoni A, Grassi F, Wulff H, D'Alessandro G, Limatola C. PMID: 29981425; PMCID: PMC6129409.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    41. Suppression of connexin 43 phosphorylation promotes astrocyte survival and vascular regeneration in proliferative retinopathy. Proc Natl Acad Sci U S A. 2018 06 26; 115(26):E5934-E5943. Slavi N, Toychiev AH, Kosmidis S, Ackert J, Bloomfield SA, Wulff H, Viswanathan S, Lampe PD, Srinivas M. PMID: 29891713; PMCID: PMC6042062.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    42. Kv1.3 activity perturbs the homeostatic properties of astrocytes in glioma. Sci Rep. 2018 05 16; 8(1):7654. Grimaldi A, D'Alessandro G, Di Castro MA, Lauro C, Singh V, Pagani F, Sforna L, Grassi F, Di Angelantonio S, Catacuzzeno L, Wulff H, Limatola C, Catalano M. PMID: 29769580; PMCID: PMC5955950.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    43. Alpha1 -adrenergic stimulation selectively enhances endothelium-mediated vasodilation in rat cremaster arteries. Physiol Rep. 2018 05; 6(9):e13703. Mishra RC, Rahman MM, Davis MJ, Wulff H, Hill MA, Braun AP. PMID: 29756401; PMCID: PMC5949301.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    44. Correction to Optimized Inhibitors of Soluble Epoxide Hydrolase Improve in Vitro Target Residence Time and in Vivo Efficacy. J Med Chem. 2018 05 10; 61(9):4271. Lee KSS, Liu JY, Wagner KM, Pakhomova S, Dong H, Morisseau C, Fu SH, Yang J, Wang P, Ulu A, Mate CA, Nguyen LV, Hwang SH, Edin ML, Mara AA, Wulff H, Newcomer ME, Zeldin DC, Hammock BD. PMID: 29701466; PMCID: PMC5949719.
      View in: PubMed   Mentions:    Fields:    
    45. A multiplatform strategy for the discovery of conventional monoclonal antibodies that inhibit the voltage-gated potassium channel Kv1.3. MAbs. 2018 May/Jun; 10(4):636-650. Bednenko J, Harriman R, Mariën L, Nguyen HM, Agrawal A, Papoyan A, Bisharyan Y, Cardarelli J, Cassidy-Hanley D, Clark T, Pedersen D, Abdiche Y, Harriman W, van der Woning B, de Haard H, Collarini E, Wulff H, Colussi P. PMID: 29494279; PMCID: PMC5973702.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    46. Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer's disease: preclinical proof of concept. Brain. 2018 02 01; 141(2):596-612. Maezawa I, Nguyen HM, Di Lucente J, Jenkins DP, Singh V, Hilt S, Kim K, Rangaraju S, Levey AI, Wulff H, Jin LW. PMID: 29272333; PMCID: PMC5837198.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    47. Targeting potassium channels to treat cerebellar ataxia. Ann Clin Transl Neurol. 2018 03; 5(3):297-314. Bushart DD, Chopra R, Singh V, Murphy GG, Wulff H, Shakkottai VG. PMID: 29560375; PMCID: PMC5846455.
      View in: PubMed   Mentions: 20     Fields:    
    48. KCa3.1 Channel Modulators as Potential Therapeutic Compounds for Glioblastoma. Curr Neuropharmacol. 2018; 16(5):618-626. Brown BM, Pressley B, Wulff H. PMID: 28676010; PMCID: PMC5997873.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    49. Inhibition of the potassium channel Kv1.3 reduces infarction and inflammation in ischemic stroke. Ann Clin Transl Neurol. 2018 02; 5(2):147-161. Chen YJ, Nguyen HM, Maezawa I, Jin LW, Wulff H. PMID: 29468176; PMCID: PMC5817832.
      View in: PubMed   Mentions: 15     Fields:    
    50. Structural insights into the potency of SK channel positive modulators. Sci Rep. 2017 12 07; 7(1):17178. Nam YW, Orfali R, Liu T, Yu K, Cui M, Wulff H, Zhang M. PMID: 29214998; PMCID: PMC5719431.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    51. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview. Br J Pharmacol. 2017 Dec; 174 Suppl 1:S1-S16. Alexander SP, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA, CGTP Collaborators. PMID: 29055037; PMCID: PMC5650665.
      View in: PubMed   Mentions: 184     Fields:    Translation:Humans
    52. The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells. Br J Cancer. 2018 01; 118(2):200-212. Pillozzi S, D'Amico M, Bartoli G, Gasparoli L, Petroni G, Crociani O, Marzo T, Guerriero A, Messori L, Severi M, Udisti R, Wulff H, Chandy KG, Becchetti A, Arcangeli A. PMID: 29161243; PMCID: PMC5785745.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    53. GABAA receptor subtype selectivity of the proconvulsant rodenticide TETS. Arch Toxicol. 2018 Feb; 92(2):833-844. Pressly B, Nguyen HM, Wulff H. PMID: 29038840; PMCID: PMC5818616.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    54. Are there superagonists for calcium-activated potassium channels? Channels (Austin). 2017 11 02; 11(6):504-506. Brown BM, Shim H, Wulff H. PMID: 28876978; PMCID: PMC5786189.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    55. Structural Determinants for the Selectivity of the Positive KCa3.1 Gating Modulator 5-Methylnaphtho[2,1-d]oxazol-2-amine (SKA-121). Mol Pharmacol. 2017 10; 92(4):469-480. Brown BM, Shim H, Zhang M, Yarov-Yarovoy V, Wulff H. PMID: 28760780; PMCID: PMC5588545.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    56. A multi-tiered, in vivo, quantitative assay suite for environmental disruptors of thyroid hormone signaling. Aquat Toxicol. 2017 Sep; 190:1-10. Mengeling BJ, Wei Y, Dobrawa LN, Streekstra M, Louisse J, Singh V, Singh L, Lein PJ, Wulff H, Murk AJ, Furlow JD. PMID: 28662416; PMCID: PMC5558850.
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    57. Development of Tetramethylenedisulfotetramine (TETS) Hapten Library: Synthesis, Electrophysiological Studies, and Immune Response in Rabbits. Chemistry. 2017 Jun 22; 23(35):8466-8472. Barnych B, Vasylieva N, Joseph T, Hulsizer S, Nguyen HM, Cajka T, Pessah I, Wulff H, Gee SJ, Hammock BD. PMID: 28411375; PMCID: PMC5808876.
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    59. From the Cover: BDE-47 and BDE-49 Inhibit Axonal Growth in Primary Rat Hippocampal Neuron-Glia Co-Cultures via Ryanodine Receptor-Dependent Mechanisms. Toxicol Sci. 2017 04 01; 156(2):375-386. Chen H, Streifel KM, Singh V, Yang D, Mangini L, Wulff H, Lein PJ. PMID: 28003438; PMCID: PMC6070026.
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    60. Hydroxy-fipronil is a new urinary biomarker of exposure to fipronil. Environ Int. 2017 06; 103:91-98. Vasylieva N, Barnych B, Wan D, El-Sheikh EA, Nguyen HM, Wulff H, McMahen R, Strynar M, Gee SJ, Hammock BD. PMID: 28343720; PMCID: PMC5432128.
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    61. Potassium channel expression and function in microglia: Plasticity and possible species variations. Channels (Austin). 2017 Jul 04; 11(4):305-315. Nguyen HM, Blomster LV, Christophersen P, Wulff H. PMID: 28277939; PMCID: PMC5555259.
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    62. Structural Insights into the Atomistic Mechanisms of Action of Small Molecule Inhibitors Targeting the KCa3.1 Channel Pore. Mol Pharmacol. 2017 04; 91(4):392-402. Nguyen HM, Singh V, Pressly B, Jenkins DP, Wulff H, Yarov-Yarovoy V. PMID: 28126850; PMCID: PMC5363711.
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    63. A Metal-Free Method for Producing MRI Contrast at Amyloid-β. J Alzheimers Dis. 2017; 55(4):1667-1681. Hilt S, Tang T, Walton JH, Budamagunta M, Maezawa I, Kálai T, Hideg K, Singh V, Wulff H, Gong Q, Jin LW, Louie A, Voss JC. PMID: 27911291; PMCID: PMC5718836.
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    64. Chapter 7 Blood-Brain Barrier Mechanisms of Edema Formation The Role of Ion Transporters and Channels. . 2017 Jan 1; 129-149. O’Donnell OM, Wulff WH, Chen CY. .
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    66. Differential Kv1.3, KCa3.1, and Kir2.1 expression in "classically" and "alternatively" activated microglia. Glia. 2017 01; 65(1):106-121. Nguyen HM, Grössinger EM, Horiuchi M, Davis KW, Jin LW, Maezawa I, Wulff H. PMID: 27696527; PMCID: PMC5113690.
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    67. Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents. Ann N Y Acad Sci. 2016 08; 1378(1):124-136. Pessah IN, Rogawski MA, Tancredi DJ, Wulff H, Zolkowska D, Bruun DA, Hammock BD, Lein PJ. PMID: 27467073; PMCID: PMC5063690.
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    68. Inhibition of soluble epoxide hydrolase as a novel approach to high dose diazepam induced hypotension. J Clin Toxicol. 2016 Jun; 6(3). Ulu A, Inceoglu B, Yang J, Singh V, Vito S, Wulff H, Hammock BD. PMID: 28255523; PMCID: PMC5328659.
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    70. Treatment with the KCa3.1 inhibitor TRAM-34 during diabetic ketoacidosis reduces inflammatory changes in the brain. Pediatr Diabetes. 2017 08; 18(5):356-366. Glaser N, Little C, Lo W, Cohen M, Tancredi D, Wulff H, O'Donnell M. PMID: 27174668.
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    71. Endothelial Small- and Intermediate-Conductance K Channels and Endothelium-Dependent Hyperpolarization as Drug Targets in Cardiovascular Disease. Adv Pharmacol. 2016; 77:65-104. Köhler R, Oliván-Viguera A, Wulff H. PMID: 27451095.
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    72. KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages. Cell Death Dis. 2016 Apr 07; 7:e2174. Grimaldi A, D'Alessandro G, Golia MT, Grössinger EM, Di Angelantonio S, Ragozzino D, Santoro A, Esposito V, Wulff H, Catalano M, Limatola C. PMID: 27054329; PMCID: PMC4855657.
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    73. KCa3.1(-/-) Mice Do Not Develop CIA: Regulatory Role for KCa3.1 in Autoimmune Arthritis. J Cell Physiol. 2016 11; 231(11):2313-4. Raychaudhuri SK, Wulff H, Raychaudhuri SP. PMID: 26910182.
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    74. Vascular Reactivity Profile of Novel KCa 3.1-Selective Positive-Gating Modulators in the Coronary Vascular Bed. Basic Clin Pharmacol Toxicol. 2016 Aug; 119(2):184-92. Oliván-Viguera A, Valero MS, Pinilla E, Amor S, García-Villalón ÁL, Coleman N, Laría C, Calvín-Tienza V, García-Otín ÁL, Fernández-Fernández JM, Murillo MD, Gálvez JA, Díaz-de-Villegas MD, Badorrey R, Simonsen U, Rivera L, Wulff H, Köhler R. PMID: 26821335; PMCID: PMC5720859.
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    75. Chasing the Elusive Benzofuran Impurity of the THR Antagonist NH-3: Synthesis, Isotope Labeling, and Biological Activity. J Org Chem. 2016 Mar 04; 81(5):1870-6. Singh L, Pressly B, Mengeling BJ, Fettinger JC, Furlow JD, Lein PJ, Wulff H, Singh V. PMID: 26849160.
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    76. Diisopropylfluorophosphate Impairs the Transport of Membrane-Bound Organelles in Rat Cortical Axons. J Pharmacol Exp Ther. 2016 Mar; 356(3):645-55. Gao J, Naughton SX, Wulff H, Singh V, Beck WD, Magrane J, Thomas B, Kaidery NA, Hernandez CM, Terry AV. PMID: 26718240; PMCID: PMC4767389.
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    77. The Concise Guide to PHARMACOLOGY 2015/16: Overview. Br J Pharmacol. 2015 Dec; 172(24):5729-43. Alexander SP, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Buneman OP, Catterall WA, Cidlowski JA, Davenport AP, Fabbro D, Fan G, McGrath JC, Spedding M, Davies JA, CGTP Collaborators. PMID: 26650438; PMCID: PMC4718217.
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    80. Interrogation of the intersubunit interface of the open Hv1 proton channel with a probe of allosteric coupling. Sci Rep. 2015 Sep 14; 5:14077. Hong L, Singh V, Wulff H, Tombola F. PMID: 26365828; PMCID: PMC4568520.
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    81. Neuronal Atrophy Early in Degenerative Ataxia Is a Compensatory Mechanism to Regulate Membrane Excitability. J Neurosci. 2015 Aug 12; 35(32):11292-307. Dell'Orco JM, Wasserman AH, Chopra R, Ingram MA, Hu YS, Singh V, Wulff H, Opal P, Orr HT, Shakkottai VG. PMID: 26269637; PMCID: PMC4532759.
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    82. A pharmacologic activator of endothelial KCa channels increases systemic conductance and reduces arterial pressure in an anesthetized pig model. Vascul Pharmacol. 2016 Apr; 79:24-31. Mishra RC, Mitchell JR, Gibbons-Kroeker C, Wulff H, Belenkie I, Tyberg JV, Braun AP. PMID: 26239885; PMCID: PMC5710011.
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    83. Pharmacological gating modulation of small- and intermediate-conductance Ca(2+)-activated K(+) channels (KCa2.x and KCa3.1). Channels (Austin). 2015; 9(6):336-43. Christophersen P, Wulff H. PMID: 26217968; PMCID: PMC4850045.
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    84. Inhibition of Myogenic Tone in Rat Cremaster and Cerebral Arteries by SKA-31, an Activator of Endothelial KCa2.3 and KCa3.1 Channels. J Cardiovasc Pharmacol. 2015 Jul; 66(1):118-27. Mishra RC, Wulff H, Hill MA, Braun AP. PMID: 25815673; PMCID: PMC4500737.
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    85. Human lung myofibroblast TGFβ1-dependent Smad2/3 signalling is Ca(2+)-dependent and regulated by KCa3.1 K(+) channels. Fibrogenesis Tissue Repair. 2015; 8:5. Roach KM, Feghali-Bostwick C, Wulff H, Amrani Y, Bradding P. PMID: 25829947; PMCID: PMC4379608.
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    86. Dysregulation of glutamine transporter SNAT1 in Rett syndrome microglia: a mechanism for mitochondrial dysfunction and neurotoxicity. J Neurosci. 2015 Feb 11; 35(6):2516-29. Jin LW, Horiuchi M, Wulff H, Liu XB, Cortopassi GA, Erickson JD, Maezawa I. PMID: 25673846; PMCID: PMC4323531.
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    88. The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant. Neurotherapeutics. 2015 Jan; 12(1):234-49. Coleman N, Nguyen HM, Cao Z, Brown BM, Jenkins DP, Zolkowska D, Chen YJ, Tanaka BS, Goldin AL, Rogawski MA, Pessah IN, Wulff H. PMID: 25256961; PMCID: PMC4322077.
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    89. Ion channels in innate and adaptive immunity. Annu Rev Immunol. 2015; 33:291-353. Feske S, Wulff H, Skolnik EY. PMID: 25861976; PMCID: PMC4822408.
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    90. Increased constitutive αSMA and Smad2/3 expression in idiopathic pulmonary fibrosis myofibroblasts is KCa3.1-dependent. Respir Res. 2014 Dec 05; 15:155. Roach KM, Wulff H, Feghali-Bostwick C, Amrani Y, Bradding P. PMID: 25476248; PMCID: PMC4263015.
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    91. Blood-brain barrier KCa3.1 channels: evidence for a role in brain Na uptake and edema in ischemic stroke. Stroke. 2015 Jan; 46(1):237-44. Chen YJ, Wallace BK, Yuen N, Jenkins DP, Wulff H, O'Donnell ME. PMID: 25477223; PMCID: PMC4276511.
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    92. A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo. Mol Pharmacol. 2015 Feb; 87(2):338-48. Oliván-Viguera A, Valero MS, Coleman N, Brown BM, Laría C, Murillo MD, Gálvez JA, Díaz-de-Villegas MD, Wulff H, Badorrey R, Köhler R. PMID: 25468883; PMCID: PMC4293453.
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    93. Vascular dysfunctions in the isolated aorta of double-transgenic hypertensive mice developing aortic aneurysm. Pflugers Arch. 2015 Sep; 467(9):1945-63. Waeckel L, Badier-Commander C, Damery T, Köhler R, Sansilvestri-Morel P, Simonet S, Vayssettes-Courchay C, Wulff H, Félétou M. PMID: 25385304.
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    94. Kv1.3 in psoriatic disease: PAP-1, a small molecule inhibitor of Kv1.3 is effective in the SCID mouse psoriasis--xenograft model. J Autoimmun. 2014 Dec; 55:63-72. Kundu-Raychaudhuri S, Chen YJ, Wulff H, Raychaudhuri SP. PMID: 25175978; PMCID: PMC4398058.
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    95. Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy. J Med Chem. 2014 Aug 28; 57(16):7016-30. Lee KS, Liu JY, Wagner KM, Pakhomova S, Dong H, Morisseau C, Fu SH, Yang J, Wang P, Ulu A, Mate CA, Nguyen LV, Hwang SH, Edin ML, Mara AA, Wulff H, Newcomer ME, Zeldin DC, Hammock BD. PMID: 25079952; PMCID: PMC4148150.
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    96. Dyclonine rescues frataxin deficiency in animal models and buccal cells of patients with Friedreich's ataxia. Hum Mol Genet. 2014 Dec 20; 23(25):6848-62. Sahdeo S, Scott BD, McMackin MZ, Jasoliya M, Brown B, Wulff H, Perlman SL, Pook MA, Cortopassi GA. PMID: 25113747; PMCID: PMC4245046.
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    98. Preserved regulation of renal perfusion pressure by small and intermediate conductance KCa channels in hypertensive mice with or without renal failure. Pflugers Arch. 2015 Apr; 467(4):817-31. Waeckel L, Bertin F, Clavreul N, Damery T, Köhler R, Paysant J, Sansilvestri-Morel P, Simonet S, Vayssettes-Courchay C, Wulff H, Verbeuren TJ, Félétou M. PMID: 24903240.
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    99. Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases. FASEB J. 2014 Sep; 28(9):3952-64. Chhabra S, Chang SC, Nguyen HM, Huq R, Tanner MR, Londono LM, Estrada R, Dhawan V, Chauhan S, Upadhyay SK, Gindin M, Hotez PJ, Valenzuela JG, Mohanty B, Swarbrick JD, Wulff H, Iadonato SP, Gutman GA, Beeton C, Pennington MW, Norton RS, Chandy KG. PMID: 24891519; PMCID: PMC4139903.
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    100. Expression of T-cell KV1.3 potassium channel correlates with pro-inflammatory cytokines and disease activity in ulcerative colitis. J Crohns Colitis. 2014 Nov; 8(11):1378-91. Koch Hansen L, Sevelsted-Møller L, Rabjerg M, Larsen D, Hansen TP, Klinge L, Wulff H, Knudsen T, Kjeldsen J, Köhler R. PMID: 24793818; PMCID: PMC4216648.
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    102. Alterations in cerebellar physiology are associated with a stiff-legged gait in Atcay(ji-hes) mice. Neurobiol Dis. 2014 Jul; 67:140-8. Luna-Cancalon K, Sikora KM, Pappas SS, Singh V, Wulff H, Paulson HL, Burmeister M, Shakkottai VG. PMID: 24727095; PMCID: PMC4059535.
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    103. Nanomolar bifenthrin alters synchronous Ca2+ oscillations and cortical neuron development independent of sodium channel activity. Mol Pharmacol. 2014 Apr; 85(4):630-9. Cao Z, Cui Y, Nguyen HM, Jenkins DP, Wulff H, Pessah IN. PMID: 24482397; PMCID: PMC3965893.
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    104. Correction: The K+ Channel KCa3.1 as a Novel Target for Idiopathic Pulmonary Fibrosis. PLoS ONE. 2014 Jan 16; 9(1). Roach RK, Duffy DS, Coward CW, Feghali-Bostwick FC, Wulff WH, Bradding BP. .
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    106. The Ca²⁺-activated K⁺ channel KCa3.1 as a potential new target for the prevention of allograft vasculopathy. PLoS One. 2013; 8(11):e81006. Chen YJ, Lam J, Gregory CR, Schrepfer S, Wulff H. PMID: 24312257; PMCID: PMC3843675.
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    110. KCa3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo. Cell Death Dis. 2013 Aug 15; 4:e773. D'Alessandro G, Catalano M, Sciaccaluga M, Chece G, Cipriani R, Rosito M, Grimaldi A, Lauro C, Cantore G, Santoro A, Fioretti B, Franciolini F, Wulff H, Limatola C. PMID: 23949222; PMCID: PMC3763441.
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    121. Ca(2+)-activated K(+) channel-3.1 blocker TRAM-34 attenuates airway remodeling and eosinophilia in a murine asthma model. Am J Respir Cell Mol Biol. 2013 Feb; 48(2):212-9. Girodet PO, Ozier A, Carvalho G, Ilina O, Ousova O, Gadeau AP, Begueret H, Wulff H, Marthan R, Bradding P, Berger P. PMID: 23204391; PMCID: PMC4035224.
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    122. SKA-31, a novel activator of SK(Ca) and IK(Ca) channels, increases coronary flow in male and female rat hearts. Cardiovasc Res. 2013 Feb 01; 97(2):339-48. Mishra RC, Belke D, Wulff H, Braun AP. PMID: 23118129; PMCID: PMC3543990.
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    123. Genetic KCa3.1-deficiency produces locomotor hyperactivity and alterations in cerebral monoamine levels. PLoS One. 2012; 7(10):e47744. Lambertsen KL, Gramsbergen JB, Sivasaravanaparan M, Ditzel N, Sevelsted-Møller LM, Oliván-Viguera A, Rabjerg M, Wulff H, Köhler R. PMID: 23077667; PMCID: PMC3471871.
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    124. Structure-activity relationship exploration of Kv1.3 blockers based on diphenoxylate. Bioorg Med Chem Lett. 2012 Dec 01; 22(23):7106-9. Nguyen W, Howard BL, Jenkins DP, Wulff H, Thompson PE, Manallack DT. PMID: 23084278; PMCID: PMC3664202.
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    125. Triarylmethanes, a new class of cx50 inhibitors. Front Pharmacol. 2012; 3:106. Bodendiek SB, Rubinos C, Trelles MP, Coleman N, Jenkins DP, Wulff H, Srinivas M. PMID: 22685432; PMCID: PMC3368247.
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    126. Microglial KCa3.1 Channels as a Potential Therapeutic Target for Alzheimer's Disease. Int J Alzheimers Dis. 2012; 2012:868972. Maezawa I, Jenkins DP, Jin BE, Wulff H. PMID: 22675649; PMCID: PMC3364551.
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    127. Does microglial dysfunction play a role in autism and Rett syndrome? Neuron Glia Biol. 2011 Feb; 7(1):85-97. Maezawa I, Calafiore M, Wulff H, Jin LW. PMID: 22717189; PMCID: PMC4976478.
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    128. Purification, molecular cloning and functional characterization of HelaTx1 (Heterometrus laoticus): the first member of a new κ-KTX subfamily. Biochem Pharmacol. 2012 May 01; 83(9):1307-17. Vandendriessche T, Kopljar I, Jenkins DP, Diego-Garcia E, Abdel-Mottaleb Y, Vermassen E, Clynen E, Schoofs L, Wulff H, Snyders D, Tytgat J. PMID: 22305749; PMCID: PMC3644210.
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    129. Pharmacological activation of KCa3.1/KCa2.3 channels produces endothelial hyperpolarization and lowers blood pressure in conscious dogs. Br J Pharmacol. 2012 Jan; 165(1):223-34. Damkjaer M, Nielsen G, Bodendiek S, Staehr M, Gramsbergen JB, de Wit C, Jensen BL, Simonsen U, Bie P, Wulff H, Köhler R. PMID: 21699504; PMCID: PMC3252979.
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    130. The Lymphocyte Potassium Channels Kv1.3 and KCa3.1 as Targets for Immunosuppression. Drug Dev Res. 2011 Nov; 72(7):573-584. Lam J, Wulff H. PMID: 22241939; PMCID: PMC3253536.
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    131. Early changes in cerebellar physiology accompany motor dysfunction in the polyglutamine disease spinocerebellar ataxia type 3. J Neurosci. 2011 Sep 07; 31(36):13002-14. Shakkottai VG, do Carmo Costa M, Dell'Orco JM, Sankaranarayanan A, Wulff H, Paulson HL. PMID: 21900579; PMCID: PMC3170039.
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    132. Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases. Toxicon. 2012 Mar 15; 59(4):529-46. Chi V, Pennington MW, Norton RS, Tarcha EJ, Londono LM, Sims-Fahey B, Upadhyay SK, Lakey JT, Iadonato S, Wulff H, Beeton C, Chandy KG. PMID: 21867724; PMCID: PMC3397671.
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    133. The KCa3.1 blocker TRAM-34 reduces infarction and neurological deficit in a rat model of ischemia/reperfusion stroke. J Cereb Blood Flow Metab. 2011 Dec; 31(12):2363-74. Chen YJ, Raman G, Bodendiek S, O'Donnell ME, Wulff H. PMID: 21750563; PMCID: PMC3323185.
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    134. Negative gating modulation by (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine (NS8593) depends on residues in the inner pore vestibule: pharmacological evidence of deep-pore gating of K(Ca)2 channels. Mol Pharmacol. 2011 Jun; 79(6):899-909. Jenkins DP, Strøbæk D, Hougaard C, Jensen ML, Hummel R, Sørensen US, Christophersen P, Wulff H. PMID: 21363929; PMCID: PMC3102549.
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    135. Improvement of endothelium-dependent vasodilations by SKA-31 and SKA-20, activators of small- and intermediate-conductance Ca2+ -activated K+ -channels. Acta Physiol (Oxf). 2011 Sep; 203(1):117-26. Hasenau AL, Nielsen G, Morisseau C, Hammock BD, Wulff H, Köhler R. PMID: 21362152; PMCID: PMC3139805.
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    136. Identification of phase-I metabolites and chronic toxicity study of the Kv1.3 blocker PAP-1 (5-(4-phenoxybutoxy)psoralen) in the rat. Xenobiotica. 2011 Mar; 41(3):198-211. Hao B, Chen ZW, Zhou XJ, Zimin PI, Miljanich GP, Wulff H, Wang YX. PMID: 21070145; PMCID: PMC3644211.
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    137. Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity. J Biol Chem. 2011 Feb 04; 286(5):3693-706. Maezawa I, Zimin PI, Wulff H, Jin LW. PMID: 20971854; PMCID: PMC3030372.
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    138. Spiro azepane-oxazolidinones as Kv1.3 potassium channel blockers: WO2010066840. Expert Opin Ther Pat. 2010 Dec; 20(12):1759-65. Wulff H. PMID: 20954790; PMCID: PMC2988097.
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    139. Potassium channel block by a tripartite complex of two cationophilic ligands and a potassium ion. Mol Pharmacol. 2010 Oct; 78(4):588-99. Zimin PI, Garic B, Bodendiek SB, Mahieux C, Wulff H, Zhorov BS. PMID: 20601455; PMCID: PMC2981387.
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    140. Therapeutic potential of KCa3.1 blockers: recent advances and promising trends. Expert Rev Clin Pharmacol. 2010 May; 3(3):385-96. Wulff H, Castle NA. PMID: 22111618; PMCID: PMC3347644.
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    141. Formulation-based approach to support early drug discovery and development efforts: a case study with enteric microencapsulation dosage form development for a triarylmethane derivative TRAM-34; a novel potential immunosuppressant. Drug Dev Ind Pharm. 2010 May; 36(5):563-9. Al-Ghananeem AM, Abbassi M, Shrestha S, Raman G, Wulff H, Pereira L, Ansari A. PMID: 19929567; PMCID: PMC3337761.
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    142. Vascular KCa-channels as therapeutic targets in hypertension and restenosis disease. Expert Opin Ther Targets. 2010 Feb; 14(2):143-55. Köhler R, Kaistha BP, Wulff H. PMID: 20055714; PMCID: PMC3644209.
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    143. Inhibition of the K+ channel KCa3.1 ameliorates T cell-mediated colitis. Proc Natl Acad Sci U S A. 2010 Jan 26; 107(4):1541-6. Di L, Srivastava S, Zhdanova O, Ding Y, Li Z, Wulff H, Lafaille M, Skolnik EY. PMID: 20080610; PMCID: PMC2824388.
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    144. Use of Kv1.3 blockers for inflammatory skin conditions. Curr Med Chem. 2010; 17(26):2882-96. Nguyen W, Howard BL, Neale DS, Thompson PE, White PJ, Wulff H, Manallack DT. PMID: 20858170; PMCID: PMC3337760.
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    145. Voltage-gated potassium channels as therapeutic targets. Nat Rev Drug Discov. 2009 Dec; 8(12):982-1001. Wulff H, Castle NA, Pardo LA. PMID: 19949402; PMCID: PMC2790170.
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    146. Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14518-23. Grgic I, Kiss E, Kaistha BP, Busch C, Kloss M, Sautter J, Müller A, Kaistha A, Schmidt C, Raman G, Wulff H, Strutz F, Gröne HJ, Köhler R, Hoyer J. PMID: 19706538; PMCID: PMC2726862.
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    147. The K+ channels K(Ca)3.1 and K(v)1.3 as novel targets for asthma therapy. Br J Pharmacol. 2009 Aug; 157(8):1330-9. Bradding P, Wulff H. PMID: 19681865; PMCID: PMC2765317.
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    148. The class II phosphatidylinositol 3 kinase C2beta is required for the activation of the K+ channel KCa3.1 and CD4 T-cells. Mol Biol Cell. 2009 Sep; 20(17):3783-91. Srivastava S, Di L, Zhdanova O, Li Z, Vardhana S, Wan Q, Yan Y, Varma R, Backer J, Wulff H, Dustin ML, Skolnik EY. PMID: 19587117; PMCID: PMC2735477.
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    149. Blockade of T-lymphocyte KCa3.1 and Kv1.3 channels as novel immunosuppression strategy to prevent kidney allograft rejection. Transplant Proc. 2009 Jul-Aug; 41(6):2601-6. Grgic I, Wulff H, Eichler I, Flothmann C, Köhler R, Hoyer J. PMID: 19715983; PMCID: PMC3343637.
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    150. Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension. Circulation. 2009 May 05; 119(17):2323-32. Brähler S, Kaistha A, Schmidt VJ, Wölfle SE, Busch C, Kaistha BP, Kacik M, Hasenau AL, Grgic I, Si H, Bond CT, Adelman JP, Wulff H, de Wit C, Hoyer J, Köhler R. PMID: 19380617.
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    151. 4-Phenoxybutoxy-substituted heterocycles--a structure-activity relationship study of blockers of the lymphocyte potassium channel Kv1.3. Eur J Med Chem. 2009 May; 44(5):1838-52. Bodendiek SB, Mahieux C, Hänsel W, Wulff H. PMID: 19056148; PMCID: PMC2662044.
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    152. Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure. Mol Pharmacol. 2009 Feb; 75(2):281-95. Sankaranarayanan A, Raman G, Busch C, Schultz T, Zimin PI, Hoyer J, Köhler R, Wulff H. PMID: 18955585; PMCID: PMC2635097.
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    153. Protein histidine phosphatase 1 negatively regulates CD4 T cells by inhibiting the K+ channel KCa3.1. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14442-6. Srivastava S, Zhdanova O, Di L, Li Z, Albaqumi M, Wulff H, Skolnik EY. PMID: 18796614; PMCID: PMC2538450.
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    154. The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. J Clin Invest. 2008 Sep; 118(9):3025-37. Toyama K, Wulff H, Chandy KG, Azam P, Raman G, Saito T, Fujiwara Y, Mattson DL, Das S, Melvin JE, Pratt PF, Hatoum OA, Gutterman DD, Harder DR, Miura H. PMID: 18688283; PMCID: PMC2496961.
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    155. New light on the "old" chloride channel blocker DIDS. ACS Chem Biol. 2008 Jul 18; 3(7):399-401. Wulff H. PMID: 18642798.
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    156. KCa3.1 potassium channels are critical for cAMP-dependent chloride secretion and cyst growth in autosomal-dominant polycystic kidney disease. Kidney Int. 2008 Sep; 74(6):740-9. Albaqumi M, Srivastava S, Li Z, Zhdnova O, Wulff H, Itani O, Wallace DP, Skolnik EY. PMID: 18547995.
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    157. K+ channel modulators for the treatment of neurological disorders and autoimmune diseases. Chem Rev. 2008 May; 108(5):1744-73. Wulff H, Zhorov BS. PMID: 18476673; PMCID: PMC2714671.
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    158. Local delivery of the KCa3.1 blocker, TRAM-34, prevents acute angioplasty-induced coronary smooth muscle phenotypic modulation and limits stenosis. Arterioscler Thromb Vasc Biol. 2008 Jun; 28(6):1084-9. Tharp DL, Wamhoff BR, Wulff H, Raman G, Cheong A, Bowles DK. PMID: 18309114; PMCID: PMC2652246.
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    159. Pharmacokinetics, toxicity, and functional studies of the selective Kv1.3 channel blocker 5-(4-phenoxybutoxy)psoralen in rhesus macaques. Exp Biol Med (Maywood). 2007 Nov; 232(10):1338-54. Pereira LE, Villinger F, Wulff H, Sankaranarayanan A, Raman G, Ansari AA. PMID: 17959847; PMCID: PMC2390884.
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    160. Targeting effector memory T-cells with Kv1.3 blockers. Curr Opin Drug Discov Devel. 2007 Jul; 10(4):438-45. Wulff H, Pennington M. PMID: 17659485.
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    161. Targeting effector memory T cells with the small molecule Kv1.3 blocker PAP-1 suppresses allergic contact dermatitis. J Invest Dermatol. 2007 Jun; 127(6):1419-29. Azam P, Sankaranarayanan A, Homerick D, Griffey S, Wulff H. PMID: 17273162; PMCID: PMC1929164.
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    162. AMA production in primary biliary cirrhosis is promoted by the TLR9 ligand CpG and suppressed by potassium channel blockers. Hepatology. 2007 Feb; 45(2):314-22. Moritoki Y, Lian ZX, Wulff H, Yang GX, Chuang YH, Lan RY, Ueno Y, Ansari AA, Coppel RL, Mackay IR, Gershwin ME. PMID: 17256753.
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    164. Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17414-9. Beeton C, Wulff H, Standifer NE, Azam P, Mullen KM, Pennington MW, Kolski-Andreaco A, Wei E, Grino A, Counts DR, Wang PH, LeeHealey CJ, S Andrews B, Sankaranarayanan A, Homerick D, Roeck WW, Tehranzadeh J, Stanhope KL, Zimin P, Havel PJ, Griffey S, Knaus HG, Nepom GT, Gutman GA, Calabresi PA, Chandy KG. PMID: 17088564; PMCID: PMC1859943.
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    165. A new class of blockers of the voltage-gated potassium channel Kv1.3 via modification of the 4- or 7-position of khellinone. J Med Chem. 2006 Feb 23; 49(4):1433-41. Harvey AJ, Baell JB, Toovey N, Homerick D, Wulff H. PMID: 16480279.
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    168. Pharmacological profiling of Orthochirus scrobiculosus toxin 1 analogs with a trimmed N-terminal domain. Mol Pharmacol. 2006 Jan; 69(1):354-62. Mouhat S, Teodorescu G, Homerick D, Visan V, Wulff H, Wu Y, Grissmer S, Darbon H, De Waard M, Sabatier JM. PMID: 16234482.
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    170. The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain. Proc Natl Acad Sci U S A. 2005 Aug 02; 102(31):11094-9. Rus H, Pardo CA, Hu L, Darrah E, Cudrici C, Niculescu T, Niculescu F, Mullen KM, Allie R, Guo L, Wulff H, Beeton C, Judge SI, Kerr DA, Knaus HG, Chandy KG, Calabresi PA. PMID: 16043714; PMCID: PMC1182417.
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    172. K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom. Biochem J. 2005 Jan 01; 385(Pt 1):95-104. Mouhat S, Visan V, Ananthakrishnan S, Wulff H, Andreotti N, Grissmer S, Darbon H, De Waard M, Sabatier JM. PMID: 15588251; PMCID: PMC1134677.
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    173. Potassium channel blockade by the sea anemone toxin ShK for the treatment of multiple sclerosis and other autoimmune diseases. Curr Med Chem. 2004 Dec; 11(23):3041-52. Norton RS, Pennington MW, Wulff H. PMID: 15578998.
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    174. K+ channel expression during B cell differentiation: implications for immunomodulation and autoimmunity. J Immunol. 2004 Jul 15; 173(2):776-86. Wulff H, Knaus HG, Pennington M, Chandy KG. PMID: 15240664.
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    175. Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. Mol Pharmacol. 2004 Jun; 65(6):1364-74. Vennekamp J, Wulff H, Beeton C, Calabresi PA, Grissmer S, Hänsel W, Chandy KG. PMID: 15155830.
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    176. K+ channels as targets for specific immunomodulation. Trends Pharmacol Sci. 2004 May; 25(5):280-9. Chandy KG, Wulff H, Beeton C, Pennington M, Gutman GA, Cahalan MD. PMID: 15120495; PMCID: PMC2749963.
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    177. Khellinone derivatives as blockers of the voltage-gated potassium channel Kv1.3: synthesis and immunosuppressive activity. J Med Chem. 2004 Apr 22; 47(9):2326-36. Baell JB, Gable RW, Harvey AJ, Toovey N, Herzog T, Hänsel W, Wulff H. PMID: 15084131.
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    178. The 'functional' dyad of scorpion toxin Pi1 is not itself a prerequisite for toxin binding to the voltage-gated Kv1.2 potassium channels. Biochem J. 2004 Jan 01; 377(Pt 1):25-36. Mouhat S, Mosbah A, Visan V, Wulff H, Delepierre M, Darbon H, Grissmer S, De Waard M, Sabatier JM. PMID: 12962541; PMCID: PMC1223833.
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    181. Blockade of the intermediate-conductance calcium-activated potassium channel as a new therapeutic strategy for restenosis. Circulation. 2003 Sep 02; 108(9):1119-25. Köhler R, Wulff H, Eichler I, Kneifel M, Neumann D, Knorr A, Grgic I, Kämpfe D, Si H, Wibawa J, Real R, Borner K, Brakemeier S, Orzechowski HD, Reusch HP, Paul M, Chandy KG, Hoyer J. PMID: 12939222.
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    182. The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS. J Clin Invest. 2003 Jun; 111(11):1703-13. Wulff H, Calabresi PA, Allie R, Yun S, Pennington M, Beeton C, Chandy KG. PMID: 12782673; PMCID: PMC156104.
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    183. A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes. J Biol Chem. 2003 Mar 14; 278(11):9928-37. Beeton C, Wulff H, Singh S, Botsko S, Crossley G, Gutman GA, Cahalan MD, Pennington M, Chandy KG. PMID: 12511563.
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    184. Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI). Eur J Hum Genet. 2002 Jan; 10(1):36-43. Bardien-Kruger S, Wulff H, Arieff Z, Brink P, Chandy KG, Corfield V. PMID: 11896454.
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    186. Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24):13942-7. Beeton C, Wulff H, Barbaria J, Clot-Faybesse O, Pennington M, Bernard D, Cahalan MD, Chandy KG, Béraud E. PMID: 11717451; PMCID: PMC61146.
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    190. Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1. J Biol Chem. 2001 Aug 24; 276(34):32040-5. Wulff H, Gutman GA, Cahalan MD, Chandy KG. PMID: 11425865.
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    191. Gallamine triethiodide selectively blocks voltage-gated potassium channels in Ranvier nodes. Gen Physiol Biophys. 2001 Mar; 20(1):83-95. Hinck D, Wulff H, Koppenhöfer E. PMID: 11508824.
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    193. Effects of three alkoxypsoralens on voltage gated ion channels in Ranvier nodes. Gen Physiol Biophys. 2000 Dec; 19(4):345-64. Düring T, Gerst F, Hänsel W, Wulff H, Koppenhöfer E. PMID: 11409838.
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    195. Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc Natl Acad Sci U S A. 2000 07 05; 97(14):8151-6. Wulff H, Miller MJ, Hansel W, Grissmer S, Cahalan MD, Chandy KG. PMID: 10884437; PMCID: PMC16685.
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    196. K(+) channel-blocking alkoxypsoralens inhibit the immune response of encephalitogenic T line cells and lymphocytes from Lewis rats challenged for experimental autoimmune encephalomyelitis. Immunopharmacology. 2000 Jun; 48(1):51-63. Strauss U, Wissel K, Jung S, Wulff H, Hänsel W, Zhu J, Rolfs A, Mix E. PMID: 10822089.
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    197. Alkoxypsoralens, novel nonpeptide blockers of Shaker-type K+ channels: synthesis and photoreactivity. J Med Chem. 1998 Nov 05; 41(23):4542-9. Wulff H, Rauer H, Düring T, Hanselmann C, Ruff K, Wrisch A, Grissmer S, Hänsel W. PMID: 9804693.
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