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Heike Wulff

Title(s)Professor, Pharmacology
SchoolUniversity of California, Davis
Address3513 GBSF
CA 95616
Phone530-754-6135
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    1. Kv1.3 inhibition attenuates neuroinflammation through disruption of microglial calcium signaling. Channels (Austin). 2021 Dec; 15(1):67-78. Fomina AF, Nguyen HM, Wulff H. PMID: 33356832.
      View in: PubMed   Mentions: 1     Fields:    
    2. Unique molecular characteristics and microglial origin of Kv1.3 channel-positive brain myeloid cells in Alzheimer's disease. Proc Natl Acad Sci U S A. 2021 Mar 16; 118(11). Ramesha S, Rayaprolu S, Bowen CA, Giver CR, Bitarafan S, Nguyen HM, Gao T, Chen MJ, Nwabueze N, Dammer EB, Engstrom AK, Xiao H, Pennati A, Seyfried NT, Katz DJ, Galipeau J, Wulff H, Waller EK, Wood LB, Levey AI, Rangaraju S. PMID: 33649184.
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    3. ATP-evoked intracellular Ca2+ transients shape the ionic permeability of human microglia from epileptic temporal cortex. J Neuroinflammation. 2021 Feb 15; 18(1):44. Palomba NP, Martinello K, Cocozza G, Casciato S, Mascia A, Di Gennaro G, Morace R, Esposito V, Wulff H, Limatola C, Fucile S. PMID: 33588880.
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    4. Structure-Activity Relationship of Neuroactive Steroids, Midazolam, and Perampanel towards Mitigating Tetramine-Triggered Activity in Murine Hippocampal Neuronal Networks. Toxicol Sci. 2021 Jan 23. Antrobus S, Pressly B, Nik AM, Wulff H, Pessah IN. PMID: 33483729.
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    5. A non-hallucinogenic psychedelic analogue with therapeutic potential. Nature. 2020 Dec 09. Cameron LP, Tombari RJ, Lu J, Pell AJ, Hurley ZQ, Ehinger Y, Vargas MV, McCarroll MN, Taylor JC, Myers-Turnbull D, Liu T, Yaghoobi B, Laskowski LJ, Anderson EI, Zhang G, Viswanathan J, Brown BM, Tjia M, Dunlap LE, Rabow ZT, Fiehn O, Wulff H, McCorvy JD, Lein PJ, Kokel D, Ron D, Peters J, Zuo Y, Olson DE. PMID: 33299186.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    6. Acute and chronic neuroinflammation is triggered by diabetic ketoacidosis in a rat model. BMJ Open Diabetes Res Care. 2020 Dec; 8(2). Glaser N, Chu S, Hung B, Fernandez L, Wulff H, Tancredi D, ODonnell ME. PMID: 33318070.
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    7. New capsaicin analogs as molecular rulers to define the permissive conformation of the mouse TRPV1 ligand-binding pocket. Elife. 2020 11 09; 9. Vu S, Singh V, Wulff H, Yarov-Yarovoy V, Zheng J. PMID: 33164749.
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    8. Identification of the Functional Binding Site for the Convulsant Tetramethylenedisulfotetramine in the Pore of the a2ß3?2 GABAA Receptor. Mol Pharmacol. 2021 Jan; 99(1):78-91. Pressly B, Lee RD, Barnych B, Hammock BD, Wulff H. PMID: 33109687.
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    9. KCa channel activation normalizes endothelial function in Type 2 Diabetic resistance arteries by improving intracellular Ca2+ mobilization. Metabolism. 2021 01; 114:154390. Mishra RC, Kyle BD, Kendrick DJ, Svystonyuk D, Kieser TM, Fedak PWM, Wulff H, Braun AP. PMID: 33039407.
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    10. Acute administration of diazepam or midazolam minimally alters long-term neuropathological effects in the rat brain following acute intoxication with diisopropylfluorophosphate. Eur J Pharmacol. 2020 Nov 05; 886:173538. Supasai S, González EA, Rowland DJ, Hobson B, Bruun DA, Guignet MA, Soares S, Singh V, Wulff H, Saito N, Harvey DJ, Lein PJ. PMID: 32898549.
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    11. Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease. J Clin Invest. 2020 Aug 03; 130(8):4195-4212. Sarkar S, Nguyen HM, Malovic E, Luo J, Langley M, Palanisamy BN, Singh N, Manne S, Neal M, Gabrielle M, Abdalla A, Anantharam P, Rokad D, Panicker N, Singh V, Ay M, Charli A, Harischandra D, Jin LW, Jin H, Rangaraju S, Anantharam V, Wulff H, Kanthasamy AG. PMID: 32597830.
      View in: PubMed   Mentions: 1     Fields:    
    12. Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice. Br J Anaesth. 2020 09; 125(3):298-307. Lai IK, Valdearcos M, Morioka K, Saxena S, Feng X, Li R, Uchida Y, Lijun A, Li W, Pan J, Koliwad S, Marcucio R, Wulff H, Maze M. PMID: 32624183.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    13. Biophysical basis for Kv1.3 regulation of membrane potential changes induced by P2X4-mediated calcium entry in microglia. Glia. 2020 Nov; 68(11):2377-2394. Nguyen HM, di Lucente J, Chen YJ, Cui Y, Ibrahim RH, Pennington MW, Jin LW, Maezawa I, Wulff H. PMID: 32525239.
      View in: PubMed   Mentions: 3     Fields:    
    14. Modulation of Lymphocyte Potassium Channel KV1.3 by Membrane-Penetrating, Joint-Targeting Immunomodulatory Plant Defensin. ACS Pharmacol Transl Sci. 2020 Aug 14; 3(4):720-736. Ong ST, Bajaj S, Tanner MR, Chang SC, Krishnarjuna B, Ng XR, Morales RAV, Chen MW, Luo D, Patel D, Yasmin S, Ng JJH, Zhuang Z, Nguyen HM, El Sahili A, Lescar J, Patil R, Charman SA, Robins EG, Goggi JL, Tan PW, Sadasivam P, Ramasamy B, Hartimath SV, Dhawan V, Bednenko J, Colussi P, Wulff H, Pennington MW, Kuyucak S, Norton RS, Beeton C, Chandy KG. PMID: 32832873.
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    15. Comparison of the toxicokinetics of the convulsants picrotoxinin and tetramethylenedisulfotetramine (TETS) in mice. Arch Toxicol. 2020 06; 94(6):1995-2007. Pressly B, Vasylieva N, Barnych B, Singh V, Singh L, Bruun DA, Hwang SH, Chen YJ, Fettinger JC, Johnnides S, Lein PJ, Yang J, Hammock BD, Wulff H. PMID: 32239239.
      View in: PubMed   Mentions: 1     Fields:    
    16. Conditional KCa3.1-transgene induction in murine skin produces pruritic eczematous dermatitis with severe epidermal hyperplasia and hyperkeratosis. PLoS One. 2020; 15(3):e0222619. Lozano-Gerona J, Oliván-Viguera A, Delgado-Wicke P, Singh V, Brown BM, Tapia-Casellas E, Pueyo E, Valero MS, Garcia-Otín ÁL, Giraldo P, Abarca-Lachen E, Surra JC, Osada J, Hamilton KL, Raychaudhuri SP, Marigil M, Juarranz Á, Wulff H, Miura H, Gilaberte Y, Köhler R. PMID: 32150577.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    17. Susceptibility of larval zebrafish to the seizurogenic activity of GABA type A receptor antagonists. Neurotoxicology. 2020 01; 76:220-234. Bandara SB, Carty DR, Singh V, Harvey DJ, Vasylieva N, Pressly B, Wulff H, Lein PJ. PMID: 31811871.
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    18. SKA-31, an activator of Ca2+-activated K+ channels, improves cardiovascular function in aging. Pharmacol Res. 2020 01; 151:104539. John CM, Khaddaj Mallat R, Mishra RC, George G, Singh V, Turnbull JD, Umeshappa CS, Kendrick DJ, Kim T, Fauzi FM, Visser F, Fedak PWM, Wulff H, Braun AP. PMID: 31707036.
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    19. The Trials and Tribulations of Structure Assisted Design of KCa Channel Activators. Front Pharmacol. 2019; 10:972. Shim H, Brown BM, Singh L, Singh V, Fettinger JC, Yarov-Yarovoy V, Wulff H. PMID: 31616290.
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    20. Pharmacology of Small- and Intermediate-Conductance Calcium-Activated Potassium Channels. Annu Rev Pharmacol Toxicol. 2020 01 06; 60:219-240. Brown BM, Shim H, Christophersen P, Wulff H. PMID: 31337271.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    21. Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 05; 18(5):339-357. Wulff H, Christophersen P, Colussi P, Chandy KG, Yarov-Yarovoy V. PMID: 30728472.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    22. Repurposing the KCa3.1 inhibitor senicapoc for Alzheimer's disease. Ann Clin Transl Neurol. 2019 Apr; 6(4):723-738. Jin LW, Lucente JD, Nguyen HM, Singh V, Singh L, Chavez M, Bushong T, Wulff H, Maezawa I. PMID: 31019997.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    23. Radiation Increases Functional KCa3.1 Expression and Invasiveness in Glioblastoma. Cancers (Basel). 2019 Feb 26; 11(3). D'Alessandro G, Monaco L, Catacuzzeno L, Antonangeli F, Santoro A, Esposito V, Franciolini F, Wulff H, Limatola C. PMID: 30813636.
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    24. Recent advances in our understanding of the structure and function of more unusual cation channels. F1000Res. 2019; 8. Brown BM, Nguyen HM, Wulff H. PMID: 30755796.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    25. The voltage-gated potassium channel Kv1.3 is required for microglial pro-inflammatory activation in vivo. Glia. 2018 09; 66(9):1881-1895. Di Lucente J, Nguyen HM, Wulff H, Jin LW, Maezawa I. PMID: 30043400.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    26. Ca2+-activated K+ channels modulate microglia affecting motor neuron survival in hSOD1G93A mice. Brain Behav Immun. 2018 10; 73:584-595. Cocozza G, di Castro MA, Carbonari L, Grimaldi A, Antonangeli F, Garofalo S, Porzia A, Madonna M, Mainiero F, Santoni A, Grassi F, Wulff H, D'Alessandro G, Limatola C. PMID: 29981425.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    27. Suppression of connexin 43 phosphorylation promotes astrocyte survival and vascular regeneration in proliferative retinopathy. Proc Natl Acad Sci U S A. 2018 06 26; 115(26):E5934-E5943. Slavi N, Toychiev AH, Kosmidis S, Ackert J, Bloomfield SA, Wulff H, Viswanathan S, Lampe PD, Srinivas M. PMID: 29891713.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    28. Kv1.3 activity perturbs the homeostatic properties of astrocytes in glioma. Sci Rep. 2018 05 16; 8(1):7654. Grimaldi A, D'Alessandro G, Di Castro MA, Lauro C, Singh V, Pagani F, Sforna L, Grassi F, Di Angelantonio S, Catacuzzeno L, Wulff H, Limatola C, Catalano M. PMID: 29769580.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    29. Alpha1 -adrenergic stimulation selectively enhances endothelium-mediated vasodilation in rat cremaster arteries. Physiol Rep. 2018 05; 6(9):e13703. Mishra RC, Rahman MM, Davis MJ, Wulff H, Hill MA, Braun AP. PMID: 29756401.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    30. Correction to Optimized Inhibitors of Soluble Epoxide Hydrolase Improve in Vitro Target Residence Time and in Vivo Efficacy. J Med Chem. 2018 05 10; 61(9):4271. Lee KSS, Liu JY, Wagner KM, Pakhomova S, Dong H, Morisseau C, Fu SH, Yang J, Wang P, Ulu A, Mate CA, Nguyen LV, Hwang SH, Edin ML, Mara AA, Wulff H, Newcomer ME, Zeldin DC, Hammock BD. PMID: 29701466.
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    31. A multiplatform strategy for the discovery of conventional monoclonal antibodies that inhibit the voltage-gated potassium channel Kv1.3. MAbs. 2018 May/Jun; 10(4):636-650. Bednenko J, Harriman R, Mariën L, Nguyen HM, Agrawal A, Papoyan A, Bisharyan Y, Cardarelli J, Cassidy-Hanley D, Clark T, Pedersen D, Abdiche Y, Harriman W, van der Woning B, de Haard H, Collarini E, Wulff H, Colussi P. PMID: 29494279.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    32. Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer's disease: preclinical proof of concept. Brain. 2018 02 01; 141(2):596-612. Maezawa I, Nguyen HM, Di Lucente J, Jenkins DP, Singh V, Hilt S, Kim K, Rangaraju S, Levey AI, Wulff H, Jin LW. PMID: 29272333.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    33. Targeting potassium channels to treat cerebellar ataxia. Ann Clin Transl Neurol. 2018 03; 5(3):297-314. Bushart DD, Chopra R, Singh V, Murphy GG, Wulff H, Shakkottai VG. PMID: 29560375.
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    34. KCa3.1 Channel Modulators as Potential Therapeutic Compounds for Glioblastoma. Curr Neuropharmacol. 2018; 16(5):618-626. Brown BM, Pressley B, Wulff H. PMID: 28676010.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    35. Inhibition of the potassium channel Kv1.3 reduces infarction and inflammation in ischemic stroke. Ann Clin Transl Neurol. 2018 02; 5(2):147-161. Chen YJ, Nguyen HM, Maezawa I, Jin LW, Wulff H. PMID: 29468176.
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    36. Structural insights into the potency of SK channel positive modulators. Sci Rep. 2017 12 07; 7(1):17178. Nam YW, Orfali R, Liu T, Yu K, Cui M, Wulff H, Zhang M. PMID: 29214998.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    37. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview. Br J Pharmacol. 2017 Dec; 174 Suppl 1:S1-S16. Alexander SP, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA. PMID: 29055037.
      View in: PubMed   Mentions: 136     Fields:    Translation:Humans
    38. The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells. Br J Cancer. 2018 01; 118(2):200-212. Pillozzi S, D'Amico M, Bartoli G, Gasparoli L, Petroni G, Crociani O, Marzo T, Guerriero A, Messori L, Severi M, Udisti R, Wulff H, Chandy KG, Becchetti A, Arcangeli A. PMID: 29161243.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    39. GABAA receptor subtype selectivity of the proconvulsant rodenticide TETS. Arch Toxicol. 2018 Feb; 92(2):833-844. Pressly B, Nguyen HM, Wulff H. PMID: 29038840.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    40. Are there superagonists for calcium-activated potassium channels? Channels (Austin). 2017 11 02; 11(6):504-506. Brown BM, Shim H, Wulff H. PMID: 28876978.
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    41. Structural Determinants for the Selectivity of the Positive KCa3.1 Gating Modulator 5-Methylnaphtho[2,1-d]oxazol-2-amine (SKA-121). Mol Pharmacol. 2017 10; 92(4):469-480. Brown BM, Shim H, Zhang M, Yarov-Yarovoy V, Wulff H. PMID: 28760780.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    42. A multi-tiered, in vivo, quantitative assay suite for environmental disruptors of thyroid hormone signaling. Aquat Toxicol. 2017 Sep; 190:1-10. Mengeling BJ, Wei Y, Dobrawa LN, Streekstra M, Louisse J, Singh V, Singh L, Lein PJ, Wulff H, Murk AJ, Furlow JD. PMID: 28662416.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    43. Development of Tetramethylenedisulfotetramine (TETS) Hapten Library: Synthesis, Electrophysiological Studies, and Immune Response in Rabbits. Chemistry. 2017 Jun 22; 23(35):8466-8472. Barnych B, Vasylieva N, Joseph T, Hulsizer S, Nguyen HM, Cajka T, Pessah I, Wulff H, Gee SJ, Hammock BD. PMID: 28411375.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    44. Rapid Throughput Analysis of GABAA Receptor Subtype Modulators and Blockers Using DiSBAC1(3) Membrane Potential Red Dye. Mol Pharmacol. 2017 07; 92(1):88-99. Nik AM, Pressly B, Singh V, Antrobus S, Hulsizer S, Rogawski MA, Wulff H, Pessah IN. PMID: 28428226.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    45. From the Cover: BDE-47 and BDE-49 Inhibit Axonal Growth in Primary Rat Hippocampal Neuron-Glia Co-Cultures via Ryanodine Receptor-Dependent Mechanisms. Toxicol Sci. 2017 04 01; 156(2):375-386. Chen H, Streifel KM, Singh V, Yang D, Mangini L, Wulff H, Lein PJ. PMID: 28003438.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    46. Hydroxy-fipronil is a new urinary biomarker of exposure to fipronil. Environ Int. 2017 06; 103:91-98. Vasylieva N, Barnych B, Wan D, El-Sheikh EA, Nguyen HM, Wulff H, McMahen R, Strynar M, Gee SJ, Hammock BD. PMID: 28343720.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    47. Potassium channel expression and function in microglia: Plasticity and possible species variations. Channels (Austin). 2017 Jul 04; 11(4):305-315. Nguyen HM, Blomster LV, Christophersen P, Wulff H. PMID: 28277939.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    48. Structural Insights into the Atomistic Mechanisms of Action of Small Molecule Inhibitors Targeting the KCa3.1 Channel Pore. Mol Pharmacol. 2017 04; 91(4):392-402. Nguyen HM, Singh V, Pressly B, Jenkins DP, Wulff H, Yarov-Yarovoy V. PMID: 28126850.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    49. A Metal-Free Method for Producing MRI Contrast at Amyloid-ß. J Alzheimers Dis. 2017; 55(4):1667-1681. Hilt S, Tang T, Walton JH, Budamagunta M, Maezawa I, Kálai T, Hideg K, Singh V, Wulff H, Gong Q, Jin LW, Louie A, Voss JC. PMID: 27911291.
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    50. Chapter 7 Blood-Brain Barrier Mechanisms of Edema Formation The Role of Ion Transporters and Channels. . 2017 Jan 1; 129-149. Martha E. O’Donnell, Heike Wulff, Yi-Je Chen. .
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    51. International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels. Pharmacol Rev. 2017 01; 69(1):1-11. Kaczmarek LK, Aldrich RW, Chandy KG, Grissmer S, Wei AD, Wulff H. PMID: 28267675.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    52. Differential Kv1.3, KCa3.1, and Kir2.1 expression in "classically" and "alternatively" activated microglia. Glia. 2017 01; 65(1):106-121. Nguyen HM, Grössinger EM, Horiuchi M, Davis KW, Jin LW, Maezawa I, Wulff H. PMID: 27696527.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    53. Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents. Ann N Y Acad Sci. 2016 08; 1378(1):124-136. Pessah IN, Rogawski MA, Tancredi DJ, Wulff H, Zolkowska D, Bruun DA, Hammock BD, Lein PJ. PMID: 27467073.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    54. Inhibition of soluble epoxide hydrolase as a novel approach to high dose diazepam induced hypotension. J Clin Toxicol. 2016 Jun; 6(3). Ulu A, Inceoglu B, Yang J, Singh V, Vito S, Wulff H, Hammock BD. PMID: 28255523.
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    55. KCa3.1 channel inhibition sensitizes malignant gliomas to temozolomide treatment. Oncotarget. 2016 May 24; 7(21):30781-96. D'Alessandro G, Grimaldi A, Chece G, Porzia A, Esposito V, Santoro A, Salvati M, Mainiero F, Ragozzino D, Di Angelantonio S, Wulff H, Catalano M, Limatola C. PMID: 27096953.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    56. Treatment with the KCa3.1 inhibitor TRAM-34 during diabetic ketoacidosis reduces inflammatory changes in the brain. Pediatr Diabetes. 2017 08; 18(5):356-366. Glaser N, Little C, Lo W, Cohen M, Tancredi D, Wulff H, O'Donnell M. PMID: 27174668.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    57. Endothelial Small- and Intermediate-Conductance K Channels and Endothelium-Dependent Hyperpolarization as Drug Targets in Cardiovascular Disease. Adv Pharmacol. 2016; 77:65-104. Köhler R, Oliván-Viguera A, Wulff H. PMID: 27451095.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    58. KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages. Cell Death Dis. 2016 Apr 07; 7:e2174. Grimaldi A, D'Alessandro G, Golia MT, Grössinger EM, Di Angelantonio S, Ragozzino D, Santoro A, Esposito V, Wulff H, Catalano M, Limatola C. PMID: 27054329.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    59. KCa3.1(-/-) Mice Do Not Develop CIA: Regulatory Role for KCa3.1 in Autoimmune Arthritis. J Cell Physiol. 2016 11; 231(11):2313-4. Raychaudhuri SK, Wulff H, Raychaudhuri SP. PMID: 26910182.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    60. Vascular Reactivity Profile of Novel KCa 3.1-Selective Positive-Gating Modulators in the Coronary Vascular Bed. Basic Clin Pharmacol Toxicol. 2016 Aug; 119(2):184-92. Oliván-Viguera A, Valero MS, Pinilla E, Amor S, García-Villalón ÁL, Coleman N, Laría C, Calvín-Tienza V, García-Otín ÁL, Fernández-Fernández JM, Murillo MD, Gálvez JA, Díaz-de-Villegas MD, Badorrey R, Simonsen U, Rivera L, Wulff H, Köhler R. PMID: 26821335.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    61. Chasing the Elusive Benzofuran Impurity of the THR Antagonist NH-3: Synthesis, Isotope Labeling, and Biological Activity. J Org Chem. 2016 Mar 04; 81(5):1870-6. Singh L, Pressly B, Mengeling BJ, Fettinger JC, Furlow JD, Lein PJ, Wulff H, Singh V. PMID: 26849160.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    62. Diisopropylfluorophosphate Impairs the Transport of Membrane-Bound Organelles in Rat Cortical Axons. J Pharmacol Exp Ther. 2016 Mar; 356(3):645-55. Gao J, Naughton SX, Wulff H, Singh V, Beck WD, Magrane J, Thomas B, Kaidery NA, Hernandez CM, Terry AV. PMID: 26718240.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    63. The Concise Guide to PHARMACOLOGY 2015/16: Overview. Br J Pharmacol. 2015 Dec; 172(24):5729-43. Alexander SP, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Buneman OP, Catterall WA, Cidlowski JA, Davenport AP, Fabbro D, Fan G, McGrath JC, Spedding M, Davies JA, . PMID: 26650438.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    64. Recent developments in ion channel pharmacology. Channels (Austin). 2015; 9(6):335. Wulff H, Christophersen P. PMID: 26646476.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    65. The potassium channel KCa3.1 constitutes a pharmacological target for neuroinflammation associated with ischemia/reperfusion stroke. J Cereb Blood Flow Metab. 2016 12; 36(12):2146-2161. Chen YJ, Nguyen HM, Maezawa I, Grössinger EM, Garing AL, Köhler R, Jin LW, Wulff H. PMID: 26661208.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    66. Interrogation of the intersubunit interface of the open Hv1 proton channel with a probe of allosteric coupling. Sci Rep. 2015 Sep 14; 5:14077. Hong L, Singh V, Wulff H, Tombola F. PMID: 26365828.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    67. Neuronal Atrophy Early in Degenerative Ataxia Is a Compensatory Mechanism to Regulate Membrane Excitability. J Neurosci. 2015 Aug 12; 35(32):11292-307. Dell'Orco JM, Wasserman AH, Chopra R, Ingram MA, Hu YS, Singh V, Wulff H, Opal P, Orr HT, Shakkottai VG. PMID: 26269637.
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    68. A pharmacologic activator of endothelial KCa channels increases systemic conductance and reduces arterial pressure in an anesthetized pig model. Vascul Pharmacol. 2016 Apr; 79:24-31. Mishra RC, Mitchell JR, Gibbons-Kroeker C, Wulff H, Belenkie I, Tyberg JV, Braun AP. PMID: 26239885.
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    69. Pharmacological gating modulation of small- and intermediate-conductance Ca(2+)-activated K(+) channels (KCa2.x and KCa3.1). Channels (Austin). 2015; 9(6):336-43. Christophersen P, Wulff H. PMID: 26217968.
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    70. Inhibition of Myogenic Tone in Rat Cremaster and Cerebral Arteries by SKA-31, an Activator of Endothelial KCa2.3 and KCa3.1 Channels. J Cardiovasc Pharmacol. 2015 Jul; 66(1):118-27. Mishra RC, Wulff H, Hill MA, Braun AP. PMID: 25815673.
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    71. Human lung myofibroblast TGFß1-dependent Smad2/3 signalling is Ca(2+)-dependent and regulated by KCa3.1 K(+) channels. Fibrogenesis Tissue Repair. 2015; 8:5. Roach KM, Feghali-Bostwick C, Wulff H, Amrani Y, Bradding P. PMID: 25829947.
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    73. Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture. Mol Pharmacol. 2015 Apr; 87(4):595-605. Cao Z, Zou X, Cui Y, Hulsizer S, Lein PJ, Wulff H, Pessah IN. PMID: 25583085.
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    74. The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant. Neurotherapeutics. 2015 Jan; 12(1):234-49. Coleman N, Nguyen HM, Cao Z, Brown BM, Jenkins DP, Zolkowska D, Chen YJ, Tanaka BS, Goldin AL, Rogawski MA, Pessah IN, Wulff H. PMID: 25256961.
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    75. Ion channels in innate and adaptive immunity. Annu Rev Immunol. 2015; 33:291-353. Feske S, Wulff H, Skolnik EY. PMID: 25861976.
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    76. Increased constitutive aSMA and Smad2/3 expression in idiopathic pulmonary fibrosis myofibroblasts is KCa3.1-dependent. Respir Res. 2014 Dec 05; 15:155. Roach KM, Wulff H, Feghali-Bostwick C, Amrani Y, Bradding P. PMID: 25476248.
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    77. Blood-brain barrier KCa3.1 channels: evidence for a role in brain Na uptake and edema in ischemic stroke. Stroke. 2015 Jan; 46(1):237-44. Chen YJ, Wallace BK, Yuen N, Jenkins DP, Wulff H, O'Donnell ME. PMID: 25477223.
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    78. A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo. Mol Pharmacol. 2015 Feb; 87(2):338-48. Oliván-Viguera A, Valero MS, Coleman N, Brown BM, Laría C, Murillo MD, Gálvez JA, Díaz-de-Villegas MD, Wulff H, Badorrey R, Köhler R. PMID: 25468883.
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    79. Vascular dysfunctions in the isolated aorta of double-transgenic hypertensive mice developing aortic aneurysm. Pflugers Arch. 2015 Sep; 467(9):1945-63. Waeckel L, Badier-Commander C, Damery T, Köhler R, Sansilvestri-Morel P, Simonet S, Vayssettes-Courchay C, Wulff H, Félétou M. PMID: 25385304.
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    80. Kv1.3 in psoriatic disease: PAP-1, a small molecule inhibitor of Kv1.3 is effective in the SCID mouse psoriasis--xenograft model. J Autoimmun. 2014 Dec; 55:63-72. Kundu-Raychaudhuri S, Chen YJ, Wulff H, Raychaudhuri SP. PMID: 25175978.
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    81. Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy. J Med Chem. 2014 Aug 28; 57(16):7016-30. Lee KS, Liu JY, Wagner KM, Pakhomova S, Dong H, Morisseau C, Fu SH, Yang J, Wang P, Ulu A, Mate CA, Nguyen LV, Hwang SH, Edin ML, Mara AA, Wulff H, Newcomer ME, Zeldin DC, Hammock BD. PMID: 25079952.
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    82. Dyclonine rescues frataxin deficiency in animal models and buccal cells of patients with Friedreich's ataxia. Hum Mol Genet. 2014 Dec 20; 23(25):6848-62. Sahdeo S, Scott BD, McMackin MZ, Jasoliya M, Brown B, Wulff H, Perlman SL, Pook MA, Cortopassi GA. PMID: 25113747.
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    84. Preserved regulation of renal perfusion pressure by small and intermediate conductance KCa channels in hypertensive mice with or without renal failure. Pflugers Arch. 2015 Apr; 467(4):817-31. Waeckel L, Bertin F, Clavreul N, Damery T, Köhler R, Paysant J, Sansilvestri-Morel P, Simonet S, Vayssettes-Courchay C, Wulff H, Verbeuren TJ, Félétou M. PMID: 24903240.
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    85. Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases. FASEB J. 2014 Sep; 28(9):3952-64. Chhabra S, Chang SC, Nguyen HM, Huq R, Tanner MR, Londono LM, Estrada R, Dhawan V, Chauhan S, Upadhyay SK, Gindin M, Hotez PJ, Valenzuela JG, Mohanty B, Swarbrick JD, Wulff H, Iadonato SP, Gutman GA, Beeton C, Pennington MW, Norton RS, Chandy KG. PMID: 24891519.
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    86. Expression of T-cell KV1.3 potassium channel correlates with pro-inflammatory cytokines and disease activity in ulcerative colitis. J Crohns Colitis. 2014 Nov; 8(11):1378-91. Koch Hansen L, Sevelsted-Møller L, Rabjerg M, Larsen D, Hansen TP, Klinge L, Wulff H, Knudsen T, Kjeldsen J, Köhler R. PMID: 24793818.
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    87. A pharmacologic activator of endothelial KCa channels enhances coronary flow in the hearts of type 2 diabetic rats. J Mol Cell Cardiol. 2014 Jul; 72:364-73. Mishra RC, Wulff H, Cole WC, Braun AP. PMID: 24787473.
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    88. Alterations in cerebellar physiology are associated with a stiff-legged gait in Atcay(ji-hes) mice. Neurobiol Dis. 2014 Jul; 67:140-8. Luna-Cancalon K, Sikora KM, Pappas SS, Singh V, Wulff H, Paulson HL, Burmeister M, Shakkottai VG. PMID: 24727095.
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    89. Nanomolar bifenthrin alters synchronous Ca2+ oscillations and cortical neuron development independent of sodium channel activity. Mol Pharmacol. 2014 Apr; 85(4):630-9. Cao Z, Cui Y, Nguyen HM, Jenkins DP, Wulff H, Pessah IN. PMID: 24482397.
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    90. Correction: The K+ Channel KCa3.1 as a Novel Target for Idiopathic Pulmonary Fibrosis. PLoS ONE. 2014 Jan 16; 9(1). Katy M Roach, Stephen Mark Duffy, William Coward, Carol Feghali-Bostwick, Heike Wulff, Peter Bradding. .
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    92. The Ca²?-activated K? channel KCa3.1 as a potential new target for the prevention of allograft vasculopathy. PLoS One. 2013; 8(11):e81006. Chen YJ, Lam J, Gregory CR, Schrepfer S, Wulff H. PMID: 24312257.
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    93. Development of a QPatch automated electrophysiology assay for identifying KCa3.1 inhibitors and activators. Assay Drug Dev Technol. 2013 Nov-Dec; 11(9-10):551-60. Jenkins DP, Yu W, Brown BM, Løjkner LD, Wulff H. PMID: 24351043.
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    94. Blocking KCa3.1 channels increases tumor cell killing by a subpopulation of human natural killer lymphocytes. PLoS One. 2013; 8(10):e76740. Koshy S, Wu D, Hu X, Tajhya RB, Huq R, Khan FS, Pennington MW, Wulff H, Yotnda P, Beeton C. PMID: 24146918.
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    95. Activation of KCa3.1 by SKA-31 induces arteriolar dilatation and lowers blood pressure in normo- and hypertensive connexin40-deficient mice. Br J Pharmacol. 2013 Sep; 170(2):293-303. Radtke J, Schmidt K, Wulff H, Köhler R, de Wit C. PMID: 23734697.
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    96. KCa3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo. Cell Death Dis. 2013 Aug 15; 4:e773. D'Alessandro G, Catalano M, Sciaccaluga M, Chece G, Cipriani R, Rosito M, Grimaldi A, Lauro C, Cantore G, Santoro A, Fioretti B, Franciolini F, Wulff H, Limatola C. PMID: 23949222.
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    97. Channels: Sticking to nooks and crannies. Nat Chem Biol. 2013 Aug; 9(8):473-4. Wulff H, Yarov-Yarovoy V. PMID: 23868316.
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    99. K(Ca)3.1 channel-blockade attenuates airway pathophysiology in a sheep model of chronic asthma. PLoS One. 2013; 8(6):e66886. Van Der Velden J, Sum G, Barker D, Koumoundouros E, Barcham G, Wulff H, Castle N, Bradding P, Snibson K. PMID: 23826167.
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    100. The intermediate conductance calcium-activated potassium channel KCa3.1 regulates vascular smooth muscle cell proliferation via controlling calcium-dependent signaling. J Biol Chem. 2013 May 31; 288(22):15843-53. Bi D, Toyama K, Lemaître V, Takai J, Fan F, Jenkins DP, Wulff H, Gutterman DD, Park F, Miura H. PMID: 23609438.
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    101. Ion channels. Thorax. 2013 Oct; 68(10):974-7. Bradding P, Wulff H. PMID: 23564342.
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    102. Novel phenolic inhibitors of small/intermediate-conductance Ca²?-activated K? channels, KCa3.1 and KCa2.3. PLoS One. 2013; 8(3):e58614. Oliván-Viguera A, Valero MS, Murillo MD, Wulff H, García-Otín AL, Arbonés-Mainar JM, Köhler R. PMID: 23516517.
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    103. Endothelial small-conductance and intermediate-conductance KCa channels: an update on their pharmacology and usefulness as cardiovascular targets. J Cardiovasc Pharmacol. 2013 Feb; 61(2):102-12. Wulff H, Köhler R. PMID: 23107876.
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    104. The potassium channel KCa3.1 as new therapeutic target for the prevention of obliterative airway disease. Transplantation. 2013 Jan 27; 95(2):285-92. Hua X, Deuse T, Chen YJ, Wulff H, Stubbendorff M, Köhler R, Miura H, Länger F, Reichenspurner H, Robbins RC, Schrepfer S. PMID: 23325003.
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    105. NS6180, a new K(Ca) 3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease. Br J Pharmacol. 2013 Jan; 168(2):432-44. Strøbæk D, Brown DT, Jenkins DP, Chen YJ, Coleman N, Ando Y, Chiu P, Jørgensen S, Demnitz J, Wulff H, Christophersen P. PMID: 22891655.
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    106. A simple device to illustrate the Einthoven triangle. Adv Physiol Educ. 2012 Dec; 36(4):319-24. Jin BE, Wulff H, Widdicombe JH, Zheng J, Bers DM, Puglisi JL. PMID: 23209014.
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    107. Ca(2+)-activated K(+) channel-3.1 blocker TRAM-34 attenuates airway remodeling and eosinophilia in a murine asthma model. Am J Respir Cell Mol Biol. 2013 Feb; 48(2):212-9. Girodet PO, Ozier A, Carvalho G, Ilina O, Ousova O, Gadeau AP, Begueret H, Wulff H, Marthan R, Bradding P, Berger P. PMID: 23204391.
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    108. SKA-31, a novel activator of SK(Ca) and IK(Ca) channels, increases coronary flow in male and female rat hearts. Cardiovasc Res. 2013 Feb 01; 97(2):339-48. Mishra RC, Belke D, Wulff H, Braun AP. PMID: 23118129.
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    109. Genetic KCa3.1-deficiency produces locomotor hyperactivity and alterations in cerebral monoamine levels. PLoS One. 2012; 7(10):e47744. Lambertsen KL, Gramsbergen JB, Sivasaravanaparan M, Ditzel N, Sevelsted-Møller LM, Oliván-Viguera A, Rabjerg M, Wulff H, Köhler R. PMID: 23077667.
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    110. Structure-activity relationship exploration of Kv1.3 blockers based on diphenoxylate. Bioorg Med Chem Lett. 2012 Dec 01; 22(23):7106-9. Nguyen W, Howard BL, Jenkins DP, Wulff H, Thompson PE, Manallack DT. PMID: 23084278.
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    111. Triarylmethanes, a new class of cx50 inhibitors. Front Pharmacol. 2012; 3:106. Bodendiek SB, Rubinos C, Trelles MP, Coleman N, Jenkins DP, Wulff H, Srinivas M. PMID: 22685432.
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    114. Purification, molecular cloning and functional characterization of HelaTx1 (Heterometrus laoticus): the first member of a new ?-KTX subfamily. Biochem Pharmacol. 2012 May 01; 83(9):1307-17. Vandendriessche T, Kopljar I, Jenkins DP, Diego-Garcia E, Abdel-Mottaleb Y, Vermassen E, Clynen E, Schoofs L, Wulff H, Snyders D, Tytgat J. PMID: 22305749.
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    115. Pharmacological activation of KCa3.1/KCa2.3 channels produces endothelial hyperpolarization and lowers blood pressure in conscious dogs. Br J Pharmacol. 2012 Jan; 165(1):223-34. Damkjaer M, Nielsen G, Bodendiek S, Staehr M, Gramsbergen JB, de Wit C, Jensen BL, Simonsen U, Bie P, Wulff H, Köhler R. PMID: 21699504.
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    116. The Lymphocyte Potassium Channels Kv1.3 and KCa3.1 as Targets for Immunosuppression. Drug Dev Res. 2011 Nov; 72(7):573-584. Lam J, Wulff H. PMID: 22241939.
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    118. Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases. Toxicon. 2012 Mar 15; 59(4):529-46. Chi V, Pennington MW, Norton RS, Tarcha EJ, Londono LM, Sims-Fahey B, Upadhyay SK, Lakey JT, Iadonato S, Wulff H, Beeton C, Chandy KG. PMID: 21867724.
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    120. Negative gating modulation by (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine (NS8593) depends on residues in the inner pore vestibule: pharmacological evidence of deep-pore gating of K(Ca)2 channels. Mol Pharmacol. 2011 Jun; 79(6):899-909. Jenkins DP, Strøbæk D, Hougaard C, Jensen ML, Hummel R, Sørensen US, Christophersen P, Wulff H. PMID: 21363929.
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    137. 4-Phenoxybutoxy-substituted heterocycles--a structure-activity relationship study of blockers of the lymphocyte potassium channel Kv1.3. Eur J Med Chem. 2009 May; 44(5):1838-52. Bodendiek SB, Mahieux C, Hänsel W, Wulff H. PMID: 19056148.
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    138. Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure. Mol Pharmacol. 2009 Feb; 75(2):281-95. Sankaranarayanan A, Raman G, Busch C, Schultz T, Zimin PI, Hoyer J, Köhler R, Wulff H. PMID: 18955585.
      View in: PubMed   Mentions: 82     Fields:    Translation:Animals
    139. Protein histidine phosphatase 1 negatively regulates CD4 T cells by inhibiting the K+ channel KCa3.1. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14442-6. Srivastava S, Zhdanova O, Di L, Li Z, Albaqumi M, Wulff H, Skolnik EY. PMID: 18796614.
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    140. The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. J Clin Invest. 2008 Sep; 118(9):3025-37. Toyama K, Wulff H, Chandy KG, Azam P, Raman G, Saito T, Fujiwara Y, Mattson DL, Das S, Melvin JE, Pratt PF, Hatoum OA, Gutterman DD, Harder DR, Miura H. PMID: 18688283.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    141. New light on the "old" chloride channel blocker DIDS. ACS Chem Biol. 2008 Jul 18; 3(7):399-401. Wulff H. PMID: 18642798.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    142. KCa3.1 potassium channels are critical for cAMP-dependent chloride secretion and cyst growth in autosomal-dominant polycystic kidney disease. Kidney Int. 2008 Sep; 74(6):740-9. Albaqumi M, Srivastava S, Li Z, Zhdnova O, Wulff H, Itani O, Wallace DP, Skolnik EY. PMID: 18547995.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    143. K+ channel modulators for the treatment of neurological disorders and autoimmune diseases. Chem Rev. 2008 May; 108(5):1744-73. Wulff H, Zhorov BS. PMID: 18476673.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimals
    144. Local delivery of the KCa3.1 blocker, TRAM-34, prevents acute angioplasty-induced coronary smooth muscle phenotypic modulation and limits stenosis. Arterioscler Thromb Vasc Biol. 2008 Jun; 28(6):1084-9. Tharp DL, Wamhoff BR, Wulff H, Raman G, Cheong A, Bowles DK. PMID: 18309114.
      View in: PubMed   Mentions: 47     Fields:    Translation:Animals
    145. Pharmacokinetics, toxicity, and functional studies of the selective Kv1.3 channel blocker 5-(4-phenoxybutoxy)psoralen in rhesus macaques. Exp Biol Med (Maywood). 2007 Nov; 232(10):1338-54. Pereira LE, Villinger F, Wulff H, Sankaranarayanan A, Raman G, Ansari AA. PMID: 17959847.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    146. Targeting effector memory T-cells with Kv1.3 blockers. Curr Opin Drug Discov Devel. 2007 Jul; 10(4):438-45. Wulff H, Pennington M. PMID: 17659485.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    147. Targeting effector memory T cells with the small molecule Kv1.3 blocker PAP-1 suppresses allergic contact dermatitis. J Invest Dermatol. 2007 Jun; 127(6):1419-29. Azam P, Sankaranarayanan A, Homerick D, Griffey S, Wulff H. PMID: 17273162.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    148. AMA production in primary biliary cirrhosis is promoted by the TLR9 ligand CpG and suppressed by potassium channel blockers. Hepatology. 2007 Feb; 45(2):314-22. Moritoki Y, Lian ZX, Wulff H, Yang GX, Chuang YH, Lan RY, Ueno Y, Ansari AA, Coppel RL, Mackay IR, Gershwin ME. PMID: 17256753.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCellsCTClinical Trials
    149. Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications. Curr Med Chem. 2007; 14(13):1437-57. Wulff H, Kolski-Andreaco A, Sankaranarayanan A, Sabatier JM, Shakkottai V. PMID: 17584055.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    150. Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17414-9. Beeton C, Wulff H, Standifer NE, Azam P, Mullen KM, Pennington MW, Kolski-Andreaco A, Wei E, Grino A, Counts DR, Wang PH, LeeHealey CJ, S Andrews B, Sankaranarayanan A, Homerick D, Roeck WW, Tehranzadeh J, Stanhope KL, Zimin P, Havel PJ, Griffey S, Knaus HG, Nepom GT, Gutman GA, Calabresi PA, Chandy KG. PMID: 17088564.
      View in: PubMed   Mentions: 187     Fields:    Translation:HumansAnimalsCells
    151. A new class of blockers of the voltage-gated potassium channel Kv1.3 via modification of the 4- or 7-position of khellinone. J Med Chem. 2006 Feb 23; 49(4):1433-41. Harvey AJ, Baell JB, Toovey N, Homerick D, Wulff H. PMID: 16480279.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    152. Kv1.3 Potassium Channel: Physiology, Pharmacology and Therapeutic Indications. . 2006 Feb 6; 29:214-274. K. George Chandy, Heike Wulff, Christine Beeton, Peter A. Calabresi, George A. Gutman, Michael Pennington. .
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    153. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. Pharmacol Rev. 2005 Dec; 57(4):463-72. Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H. PMID: 16382103.
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    154. Pharmacological profiling of Orthochirus scrobiculosus toxin 1 analogs with a trimmed N-terminal domain. Mol Pharmacol. 2006 Jan; 69(1):354-62. Mouhat S, Teodorescu G, Homerick D, Visan V, Wulff H, Wu Y, Grissmer S, Darbon H, De Waard M, Sabatier JM. PMID: 16234482.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    155. Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases. Mol Pharmacol. 2005 Nov; 68(5):1254-70. Schmitz A, Sankaranarayanan A, Azam P, Schmidt-Lassen K, Homerick D, Hänsel W, Wulff H. PMID: 16099841.
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    156. The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain. Proc Natl Acad Sci U S A. 2005 Aug 02; 102(31):11094-9. Rus H, Pardo CA, Hu L, Darrah E, Cudrici C, Niculescu T, Niculescu F, Mullen KM, Allie R, Guo L, Wulff H, Beeton C, Judge SI, Kerr DA, Knaus HG, Chandy KG, Calabresi PA. PMID: 16043714.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    157. Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases. Mol Pharmacol. 2005 Apr; 67(4):1369-81. Beeton C, Pennington MW, Wulff H, Singh S, Nugent D, Crossley G, Khaytin I, Calabresi PA, Chen CY, Gutman GA, Chandy KG. PMID: 15665253.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    158. K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom. Biochem J. 2005 Jan 01; 385(Pt 1):95-104. Mouhat S, Visan V, Ananthakrishnan S, Wulff H, Andreotti N, Grissmer S, Darbon H, De Waard M, Sabatier JM. PMID: 15588251.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    159. Potassium channel blockade by the sea anemone toxin ShK for the treatment of multiple sclerosis and other autoimmune diseases. Curr Med Chem. 2004 Dec; 11(23):3041-52. Norton RS, Pennington MW, Wulff H. PMID: 15578998.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    160. K+ channel expression during B cell differentiation: implications for immunomodulation and autoimmunity. J Immunol. 2004 Jul 15; 173(2):776-86. Wulff H, Knaus HG, Pennington M, Chandy KG. PMID: 15240664.
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    161. Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. Mol Pharmacol. 2004 Jun; 65(6):1364-74. Vennekamp J, Wulff H, Beeton C, Calabresi PA, Grissmer S, Hänsel W, Chandy KG. PMID: 15155830.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    162. K+ channels as targets for specific immunomodulation. Trends Pharmacol Sci. 2004 May; 25(5):280-9. Chandy KG, Wulff H, Beeton C, Pennington M, Gutman GA, Cahalan MD. PMID: 15120495.
      View in: PubMed   Mentions: 154     Fields:    Translation:HumansCells
    163. Khellinone derivatives as blockers of the voltage-gated potassium channel Kv1.3: synthesis and immunosuppressive activity. J Med Chem. 2004 Apr 22; 47(9):2326-36. Baell JB, Gable RW, Harvey AJ, Toovey N, Herzog T, Hänsel W, Wulff H. PMID: 15084131.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    164. The 'functional' dyad of scorpion toxin Pi1 is not itself a prerequisite for toxin binding to the voltage-gated Kv1.2 potassium channels. Biochem J. 2004 Jan 01; 377(Pt 1):25-36. Mouhat S, Mosbah A, Visan V, Wulff H, Delepierre M, Darbon H, Grissmer S, De Waard M, Sabatier JM. PMID: 12962541.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    165. International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev. 2003 Dec; 55(4):583-6. Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M, Lesage F, Lester HA, McKinnon D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M, Seino S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, Wymore RS. PMID: 14657415.
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    166. Potassium channels as therapeutic targets for autoimmune disorders. Curr Opin Drug Discov Devel. 2003 Sep; 6(5):640-7. Wulff H, Beeton C, Chandy KG. PMID: 14579513.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    167. Blockade of the intermediate-conductance calcium-activated potassium channel as a new therapeutic strategy for restenosis. Circulation. 2003 Sep 02; 108(9):1119-25. Köhler R, Wulff H, Eichler I, Kneifel M, Neumann D, Knorr A, Grgic I, Kämpfe D, Si H, Wibawa J, Real R, Borner K, Brakemeier S, Orzechowski HD, Reusch HP, Paul M, Chandy KG, Hoyer J. PMID: 12939222.
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    168. The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS. J Clin Invest. 2003 Jun; 111(11):1703-13. Wulff H, Calabresi PA, Allie R, Yun S, Pennington M, Beeton C, Chandy KG. PMID: 12782673.
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    169. A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes. J Biol Chem. 2003 Mar 14; 278(11):9928-37. Beeton C, Wulff H, Singh S, Botsko S, Crossley G, Gutman GA, Cahalan MD, Pennington M, Chandy KG. PMID: 12511563.
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    170. Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI). Eur J Hum Genet. 2002 Jan; 10(1):36-43. Bardien-Kruger S, Wulff H, Arieff Z, Brink P, Chandy KG, Corfield V. PMID: 11896454.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    171. Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. J Biol Chem. 2002 Feb 01; 277(5):3793-800. Ayabe T, Wulff H, Darmoul D, Cahalan MD, Chandy KG, Ouellette AJ. PMID: 11724775.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    172. Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24):13942-7. Beeton C, Wulff H, Barbaria J, Clot-Faybesse O, Pennington M, Bernard D, Cahalan MD, Chandy KG, Béraud E. PMID: 11717451.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    173. Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants. Toxicon. 2001 Sep; 39(9):1269-76. Chandy KG, Cahalan M, Pennington M, Norton RS, Wulff H, Gutman GA. PMID: 11384714.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    174. Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2. J Biol Chem. 2001 Nov 16; 276(46):43145-51. Shakkottai VG, Regaya I, Wulff H, Fajloun Z, Tomita H, Fathallah M, Cahalan MD, Gargus JJ, Sabatier JM, Chandy KG. PMID: 11527975.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    175. Molecular properties and physiological roles of ion channels in the immune system. J Clin Immunol. 2001 Jul; 21(4):235-52. Cahalan MD, Wulff H, Chandy KG. PMID: 11506193.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    176. Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1. J Biol Chem. 2001 Aug 24; 276(34):32040-5. Wulff H, Gutman GA, Cahalan MD, Chandy KG. PMID: 11425865.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    177. Gallamine triethiodide selectively blocks voltage-gated potassium channels in Ranvier nodes. Gen Physiol Biophys. 2001 Mar; 20(1):83-95. Hinck D, Wulff H, Koppenhöfer E. PMID: 11508824.
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    178. Calcium-activated potassium channels sustain calcium signaling in T lymphocytes. Selective blockers and manipulated channel expression levels. J Biol Chem. 2001 Apr 13; 276(15):12249-56. Fanger CM, Rauer H, Neben AL, Miller MJ, Rauer H, Wulff H, Rosa JC, Ganellin CR, Chandy KG, Cahalan MD. PMID: 11278890.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    179. Effects of three alkoxypsoralens on voltage gated ion channels in Ranvier nodes. Gen Physiol Biophys. 2000 Dec; 19(4):345-64. Düring T, Gerst F, Hänsel W, Wulff H, Koppenhöfer E. PMID: 11409838.
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    180. Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences. J Biol Chem. 2000 Nov 24; 275(47):37137-49. Ghanshani S, Wulff H, Miller MJ, Rohm H, Neben A, Gutman GA, Cahalan MD, Chandy KG. PMID: 10961988.
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    181. Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc Natl Acad Sci U S A. 2000 Jul 05; 97(14):8151-6. Wulff H, Miller MJ, Hansel W, Grissmer S, Cahalan MD, Chandy KG. PMID: 10884437.
      View in: PubMed   Mentions: 237     Fields:    Translation:HumansCells
    182. K(+) channel-blocking alkoxypsoralens inhibit the immune response of encephalitogenic T line cells and lymphocytes from Lewis rats challenged for experimental autoimmune encephalomyelitis. Immunopharmacology. 2000 Jun; 48(1):51-63. Strauss U, Wissel K, Jung S, Wulff H, Hänsel W, Zhu J, Rolfs A, Mix E. PMID: 10822089.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    183. Alkoxypsoralens, novel nonpeptide blockers of Shaker-type K+ channels: synthesis and photoreactivity. J Med Chem. 1998 Nov 05; 41(23):4542-9. Wulff H, Rauer H, Düring T, Hanselmann C, Ruff K, Wrisch A, Grissmer S, Hänsel W. PMID: 9804693.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
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