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Jonathan Widdicombe

Title(s)Professor Emeritus, Physiology and Membrane Biology
SchoolUniversity of California, Davis
Phone530-754-7369
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Widdicombe JH. Early studies on the surface epithelium of mammalian airways. Am J Physiol Lung Cell Mol Physiol. 2019 Oct 01; 317(4):L486-L495. PMID: 31313615.
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    2. Widdicombe JH. Early studies of airway submucosal glands. Am J Physiol Lung Cell Mol Physiol. 2019 Jun 01; 316(6):L990-L998. PMID: 30864819.
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    3. Widdicombe JH, Wine JJ. Airway Gland Structure and Function. Physiol Rev. 2015 Oct; 95(4):1241-319. PMID: 26336032.
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    4. Hajighasemi-Ossareh M, Borthwell RM, Lachowicz-Scroggins M, Stevens JE, Finkbeiner WE, Widdicombe JH. Distribution and size of mucous glands in the ferret tracheobronchial tree. Anat Rec (Hoboken). 2013 Nov; 296(11):1768-74. PMID: 24106034.
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    5. Jin BE, Wulff H, Widdicombe JH, Zheng J, Bers DM, Puglisi JL. A simple device to illustrate the Einthoven triangle. Adv Physiol Educ. 2012 Dec; 36(4):319-24. PMID: 23209014.
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    6. Rajagopal M, Kathpalia PP, Widdicombe JH, Pao AC. Differential effects of extracellular ATP on chloride transport in cortical collecting duct cells. Am J Physiol Renal Physiol. 2012 Aug 15; 303(4):F483-91. PMID: 22647633.
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    7. Widdicombe JH, Borthwell RM, Hajighasemi-Ossareh M, Lachowicz-Scroggins ME, Finkbeiner WE, Stevens JE, Modlin S. Chloride secretion by cultures of pig tracheal gland cells. Am J Physiol Lung Cell Mol Physiol. 2012 May 15; 302(10):L1098-106. PMID: 22367783.
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    8. Finkbeiner WE, Zlock LT, Morikawa M, Lao AY, Dasari V, Widdicombe JH. Cystic fibrosis and the relationship between mucin and chloride secretion by cultures of human airway gland mucous cells. Am J Physiol Lung Cell Mol Physiol. 2011 Oct; 301(4):L402-14. PMID: 21724859.
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    9. Sachs LA, Schnurr D, Yagi S, Lachowicz-Scroggins ME, Widdicombe JH. Quantitative real-time PCR for rhinovirus, and its use in determining the relationship between TCID50 and the number of viral particles. J Virol Methods. 2011 Jan; 171(1):212-8. PMID: 21070809.
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    10. Widdicombe JH. Transgenic animals may help resolve a sticky situation in cystic fibrosis. J Clin Invest. 2010 Sep; 120(9):3093-6. PMID: 20739746.
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    11. Fischer H, Illek B, Sachs L, Finkbeiner WE, Widdicombe JH. CFTR and calcium-activated chloride channels in primary cultures of human airway gland cells of serous or mucous phenotype. Am J Physiol Lung Cell Mol Physiol. 2010 Oct; 299(4):L585-94. PMID: 20675434.
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    12. Lachowicz-Scroggins ME, Boushey HA, Finkbeiner WE, Widdicombe JH. Interleukin-13-induced mucous metaplasia increases susceptibility of human airway epithelium to rhinovirus infection. Am J Respir Cell Mol Biol. 2010 Dec; 43(6):652-61. PMID: 20081054.
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    13. Finkbeiner WE, Zlock LT, Mehdi I, Widdicombe JH. Cultures of human tracheal gland cells of mucous or serous phenotype. In Vitro Cell Dev Biol Anim. 2010 May; 46(5):450-6. PMID: 19998060.
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    14. Lopez-Souza N, Favoreto S, Wong H, Ward T, Yagi S, Schnurr D, Finkbeiner WE, Dolganov GM, Widdicombe JH, Boushey HA, Avila PC. In vitro susceptibility to rhinovirus infection is greater for bronchial than for nasal airway epithelial cells in human subjects. J Allergy Clin Immunol. 2009 Jun; 123(6):1384-90.e2. PMID: 19428098.
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    15. Rajagopal M, Fischer H, Widdicombe JH. Hormonal and purinergic stimulation of bicarbonate secretion in oviducts of rhesus monkey. Am J Physiol Endocrinol Metab. 2008 Jul; 295(1):E55-62. PMID: 18430967.
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    16. Fischer H, Illek B, Finkbeiner WE, Widdicombe JH. Basolateral Cl channels in primary airway epithelial cultures. Am J Physiol Lung Cell Mol Physiol. 2007 Jun; 292(6):L1432-43. PMID: 17322286.
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    17. Fischer H, Widdicombe JH. Mechanisms of acid and base secretion by the airway epithelium. J Membr Biol. 2006; 211(3):139-50. PMID: 17091214.
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    18. Maurisse R, Cheung J, Widdicombe J, Gruenert DC. Modification of the pig CFTR gene mediated by small fragment homologous replacement. Ann N Y Acad Sci. 2006 Oct; 1082:120-3. PMID: 17145933.
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    19. Rajagopal M, Tollner TL, Finkbeiner WE, Cherr GN, Widdicombe JH. Differentiated structure and function of primary cultures of monkey oviductal epithelium. In Vitro Cell Dev Biol Anim. 2006 Sep-Oct; 42(8-9):248-54. PMID: 17163779.
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    20. Wilson M, Widdicombe JH, Gohil K, Burtis KC, Reznick AZ, Cross CE, Eiserich JP. Are Drosophila a useful model for understanding the toxicity of inhaled oxidative pollutants: a review. Inhal Toxicol. 2005 Dec 01; 17(13):765-74. PMID: 16195212.
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    21. Tseng J, Do J, Widdicombe JH, Machen TE. Innate immune responses of human tracheal epithelium to Pseudomonas aeruginosa flagellin, TNF-alpha, and IL-1beta. Am J Physiol Cell Physiol. 2006 Mar; 290(3):C678-90. PMID: 16251478.
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    22. Widdicombe JH, Sachs LA, Morrow JL, Finkbeiner WE. Expansion of cultures of human tracheal epithelium with maintenance of differentiated structure and function. Biotechniques. 2005 Aug; 39(2):249-55. PMID: 16116798.
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    23. Moody M, Pennington C, Schultz C, Caldwell R, Dinkel C, Rossi MW, McNamara S, Widdicombe J, Gabriel S, Traynor-Kaplan AE. Inositol polyphosphate derivative inhibits Na+ transport and improves fluid dynamics in cystic fibrosis airway epithelia. Am J Physiol Cell Physiol. 2005 Sep; 289(3):C512-20. PMID: 15857902.
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    24. Fischer H, Machen TE, Widdicombe JH, Carlson TJ, King SR, Chow JW, Illek B. A novel extract SB-300 from the stem bark latex of Croton lechleri inhibits CFTR-mediated chloride secretion in human colonic epithelial cells. J Ethnopharmacol. 2004 Aug; 93(2-3):351-7. PMID: 15234776.
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    25. Dubin RF, Robinson SK, Widdicombe JH. Secretion of lactoferrin and lysozyme by cultures of human airway epithelium. Am J Physiol Lung Cell Mol Physiol. 2004 Apr; 286(4):L750-5. PMID: 15003937.
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    26. Lopez-Souza N, Dolganov G, Dubin R, Sachs LA, Sassina L, Sporer H, Yagi S, Schnurr D, Boushey HA, Widdicombe JH. Resistance of differentiated human airway epithelium to infection by rhinovirus. Am J Physiol Lung Cell Mol Physiol. 2004 Feb; 286(2):L373-81. PMID: 14711802.
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    27. Serikov VB, Choi H, Schmiel K, Skaggs C, Fleming NW, Wu R, Widdicombe JH. Endotoxin induces leukocyte transmigration and changes in permeability of the airway epithelium via protein-kinase C and extracellular regulated kinase activation. J Endotoxin Res. 2004; 10(1):55-65. PMID: 15025824.
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    28. Serikov VB, Choi H, Chmiel KJ, Wu R, Widdicombe JH. Activation of extracellular regulated kinases is required for the increase in airway epithelial permeability during leukocyte transmigration. Am J Respir Cell Mol Biol. 2004 Mar; 30(3):261-70. PMID: 12842851.
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    29. Lopez-Souza N, Avila PC, Widdicombe JH. Polarized cultures of human airway epithelium from nasal scrapings and bronchial brushings. In Vitro Cell Dev Biol Anim. 2003 Jul-Aug; 39(7):266-9. PMID: 14531727.
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    30. Chung NC, Illek B, Widdicombe JH, Fischer H. Measurement of nasal potential difference in mild asthmatics. Chest. 2003 May; 123(5):1467-71. PMID: 12740262.
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    31. Widdicombe JH, Sachs LA, Finkbeiner WE. Effects of growth surface on differentiation of cultures of human tracheal epithelium. In Vitro Cell Dev Biol Anim. 2003 Jan-Feb; 39(1-2):51-5. PMID: 12892527.
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    32. Sachs LA, Finkbeiner WE, Widdicombe JH. Effects of media on differentiation of cultured human tracheal epithelium. In Vitro Cell Dev Biol Anim. 2003 Jan-Feb; 39(1-2):56-62. PMID: 12892528.
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    33. Widdicombe JH. Regulation of the depth and composition of airway surface liquid. J Anat. 2002 Oct; 201(4):313-8. PMID: 12430955.
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    34. Widdicombe JH, Pecson IS. Distribution and numbers of mucous glands in the horse trachea. Equine Vet J. 2002 Sep; 34(6):630-3. PMID: 12358006.
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    35. Widdicombe JH. Volume of airway surface liquid in health and disease. Am J Respir Crit Care Med. 2002 Jun 01; 165(11):1566. PMID: 12045135.
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    36. Fischer H, Widdicombe JH, Illek B. Acid secretion and proton conductance in human airway epithelium. Am J Physiol Cell Physiol. 2002 Apr; 282(4):C736-43. PMID: 11880261.
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    37. Serikov VB, Jang YJ, Widdicombe JH. Estimate of the subepithelial hydrostatic pressure that drives inflammatory transudate into the airway lumen. J Appl Physiol (1985). 2002 Apr; 92(4):1702-8. PMID: 11896040.
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    38. Johnson MD, Widdicombe JH, Allen L, Barbry P, Dobbs LG. Alveolar epithelial type I cells contain transport proteins and transport sodium, supporting an active role for type I cells in regulation of lung liquid homeostasis. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):1966-71. PMID: 11842214.
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    39. Widdicombe JH. Altered NaCl concentration of airway surface liquid in cystic fibrosis. Pflugers Arch. 2001; 443 Suppl 1:S8-10. PMID: 11845295.
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    40. Widdicombe JH, Chen LL, Sporer H, Choi HK, Pecson IS, Bastacky SJ. Distribution of tracheal and laryngeal mucous glands in some rodents and the rabbit. J Anat. 2001 Feb; 198(Pt 2):207-21. PMID: 11273045.
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    41. Choi HK, Finkbeiner WE, Widdicombe JH. A comparative study of mammalian tracheal mucous glands. J Anat. 2000 Oct; 197 Pt 3:361-72. PMID: 11117623.
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    42. Widdicombe JH. Yet another role for the cystic fibrosis transmembrane conductance regulator. Am J Respir Cell Mol Biol. 2000 Jan; 22(1):11-4. PMID: 10615060.
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    43. Jiang C, Finkbeiner WE, Widdicombe JH, Fang SL, Wang KX, Nietupski JB, Hehir KM, Cheng SH. Restoration of cyclic adenosine monophosphate-stimulated chloride channel activity in human cystic fibrosis tracheobronchial submucosal gland cells by adenovirus-mediated and cationic lipid-mediated gene transfer. Am J Respir Cell Mol Biol. 1999 Jun; 20(6):1107-15. PMID: 10340929.
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    44. Widdicombe JH. Altered NaCl Concentration of Airway Surface Liquid in Cystic Fibrosis. News Physiol Sci. 1999 Jun; 14:126-127. PMID: 11390837.
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    45. Shen BQ, Widdicomb JH, Mrsny RJ. Hepatocyte growth factor inhibits amiloride-sensitive Na(+) channel function in cystic fibrosis airway epithelium in vitro. Pulm Pharmacol Ther. 1999; 12(3):157-64. PMID: 10419835.
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    46. Uyekubo SN, Fischer H, Maminishkis A, Illek B, Miller SS, Widdicombe JH. cAMP-dependent absorption of chloride across airway epithelium. Am J Physiol. 1998 12; 275(6):L1219-27. PMID: 9843860.
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    47. Evans DJ, Matsumoto PS, Widdicombe JH, Li-Yun C, Maminishkis AA, Miller SS. Pseudomonas aeruginosa induces changes in fluid transport across airway surface epithelia. Am J Physiol. 1998 11; 275(5):C1284-90. PMID: 9814977.
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    48. Zabner J, Smith JJ, Karp PH, Widdicombe JH, Welsh MJ. Loss of CFTR chloride channels alters salt absorption by cystic fibrosis airway epithelia in vitro. Mol Cell. 1998 Sep; 2(3):397-403. PMID: 9774978.
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    49. Zhang L, Wang D, Fischer H, Fan PD, Widdicombe JH, Kan YW, Dong JY. Efficient expression of CFTR function with adeno-associated virus vectors that carry shortened CFTR genes. Proc Natl Acad Sci U S A. 1998 Aug 18; 95(17):10158-63. PMID: 9707617.
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    50. Wu DX, Lee CY, Uyekubo SN, Choi HK, Bastacky SJ, Widdicombe JH. Regulation of the depth of surface liquid in bovine trachea. Am J Physiol. 1998 03; 274(3):L388-95. PMID: 9530174.
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    51. Lee MC, Penland CM, Widdicombe JH, Wine JJ. Evidence that Calu-3 human airway cells secrete bicarbonate. Am J Physiol. 1998 03; 274(3):L450-3. PMID: 9530182.
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    52. Widdicombe JH, Bastacky SJ, Wu DX, Lee CY. Regulation of depth and composition of airway surface liquid. Eur Respir J. 1997 Dec; 10(12):2892-7. PMID: 9493680.
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    53. Lee CY, Matsumoto-Pon J, Widdicombe JH. Cultured lung epithelium: A cellular model for lung preservation. Cryobiology. 1997 Nov; 35(3):209-18. PMID: 9367609.
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    54. Xiong X, Bragin A, Widdicombe JH, Cohn J, Skach WR. Structural cues involved in endoplasmic reticulum degradation of G85E and G91R mutant cystic fibrosis transmembrane conductance regulator. J Clin Invest. 1997 Sep 01; 100(5):1079-88. PMID: 9276724.
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    55. Jiang C, Finkbeiner WE, Widdicombe JH, Miller SS. Fluid transport across cultures of human tracheal glands is altered in cystic fibrosis. J Physiol. 1997 Jun 15; 501 ( Pt 3):637-47. PMID: 9218222.
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    56. Shen BQ, Panos RJ, Hansen-Guzmán K, Widdicombe JH, Mrsny RJ. Hepatocyte growth factor stimulates the differentiation of human tracheal epithelia in vitro. Am J Physiol. 1997 Jun; 272(6 Pt 1):L1115-20. PMID: 9227512.
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    57. Azizi F, Matsumoto PS, Wu DX, Widdicombe JH. Effects of hydrostatic pressure on permeability of airway epithelium. Exp Lung Res. 1997 May-Jun; 23(3):257-67. PMID: 9184792.
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    58. Wu DX, Lee CY, Widdicombe JH, Bastacky J. Ultrastructure of tracheal surface liquid: low-temperature scanning electron microscopy. Scanning. 1996 Nov; 18(8):589-92. PMID: 8946773.
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    59. Widdicombe JH, Azizi F, Kang T, Pittet JF. Transient permeabilization of airway epithelium by mucosal water. J Appl Physiol (1985). 1996 Jul; 81(1):491-9. PMID: 8828701.
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    60. Sawa T, Miyazaki H, Pittet JF, Widdicombe JH, Gropper MA, Hashimoto S, Conrad DJ, Folkesson HG, Debs R, Forsayeth JR, Fox B, Wiener-Kronish JP. Intraluminal water increases expression of plasmid DNA in rat lung. Hum Gene Ther. 1996 May 20; 7(8):933-41. PMID: 8727507.
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    61. Shen BQ, Mrsny RJ, Finkbeiner WE, Widdicombe JH. Role of CFTR in chloride secretion across human tracheal epithelium. Am J Physiol. 1995 Nov; 269(5 Pt 1):L561-6. PMID: 7491973.
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    62. Shen BQ, Widdicombe JH, Mrsny RJ. Effects of lovastatin on trafficking of cystic fibrosis transmembrane conductance regulator in human tracheal epithelium. J Biol Chem. 1995 Oct 20; 270(42):25102-6. PMID: 7559642.
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    63. Illek B, Fischer H, Santos GF, Widdicombe JH, Machen TE, Reenstra WW. cAMP-independent activation of CFTR Cl channels by the tyrosine kinase inhibitor genistein. Am J Physiol. 1995 Apr; 268(4 Pt 1):C886-93. PMID: 7537452.
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    64. Ohrui T, Shen BQ, Mrsny RJ, Widdicombe JH. A method for measuring Cl efflux from dispersed cells of airway epithelium. J Appl Physiol (1985). 1995 Mar; 78(3):1197-202. PMID: 7539784.
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    65. Gruenert DC, Finkbeiner WE, Widdicombe JH. Culture and transformation of human airway epithelial cells. Am J Physiol. 1995 Mar; 268(3 Pt 1):L347-60. PMID: 7900815.
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    66. Widdicombe JH, Widdicombe JG. Regulation of human airway surface liquid. Respir Physiol. 1995 Jan; 99(1):3-12. PMID: 7740210.
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    67. Finbeiner WE, Widdicombe JH. Serial propagation of cells from human tracheobronchial glands. In Vitro Cell Dev Biol Anim. 1994 Dec; 30A(12):817-8. PMID: 7894771.
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    68. Widdicombe JH. Accumulation of airway mucus in cystic fibrosis. Pulm Pharmacol. 1994 Aug; 7(4):225-33. PMID: 7620238.
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    69. Finkbeiner WE, Shen BQ, Widdicombe JH. Chloride secretion and function of serous and mucous cells of human airway glands. Am J Physiol. 1994 Aug; 267(2 Pt 1):L206-10. PMID: 7521139.
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    70. Ohrui T, Skach W, Thompson M, Matsumoto-Pon J, Calayag C, Widdicombe JH. Radiotracer studies of cystic fibrosis transmembrane conductance regulator expressed in Xenopus oocytes. Am J Physiol. 1994 Jun; 266(6 Pt 1):C1586-93. PMID: 7517633.
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    71. Shen BQ, Finkbeiner WE, Wine JJ, Mrsny RJ, Widdicombe JH. Calu-3: a human airway epithelial cell line that shows cAMP-dependent Cl- secretion. Am J Physiol. 1994 May; 266(5 Pt 1):L493-501. PMID: 7515578.
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    72. Haws C, Finkbeiner WE, Widdicombe JH, Wine JJ. CFTR in Calu-3 human airway cells: channel properties and role in cAMP-activated Cl- conductance. Am J Physiol. 1994 May; 266(5 Pt 1):L502-12. PMID: 7515579.
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    73. Wine JJ, Finkbeiner WE, Haws C, Krouse ME, Moon S, Widdicombe JH, Xia Y. CFTR and other Cl- channels in human airway cells. Jpn J Physiol. 1994; 44 Suppl 2:S199-205. PMID: 7752526.
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    74. Cozens AL, Yezzi MJ, Kunzelmann K, Ohrui T, Chin L, Eng K, Finkbeiner WE, Widdicombe JH, Gruenert DC. CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells. Am J Respir Cell Mol Biol. 1994 Jan; 10(1):38-47. PMID: 7507342.
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    75. Jiang C, Finkbeiner WE, Widdicombe JH, McCray PB, Miller SS. Altered fluid transport across airway epithelium in cystic fibrosis. Science. 1993 Oct 15; 262(5132):424-7. PMID: 8211164.
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    76. Shen BQ, Barthelson RA, Skach W, Gruenert DC, Sigal E, Mrsny RJ, Widdicombe JH. Mechanism of inhibition of cAMP-dependent epithelial chloride secretion by phorbol esters. J Biol Chem. 1993 Sep 05; 268(25):19070-5. PMID: 7689566.
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    77. Yamaya M, Ohrui T, Finkbeiner WE, Widdicombe JH. Calcium-dependent chloride secretion across cultures of human tracheal surface epithelium and glands. Am J Physiol. 1993 Aug; 265(2 Pt 1):L170-7. PMID: 8396338.
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    78. Kondo M, Finkbeiner WE, Widdicombe JH. Cultures of bovine tracheal epithelium with differentiated ultrastructure and ion transport. In Vitro Cell Dev Biol. 1993 Jan; 29A(1):19-24. PMID: 8444742.
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    79. Yamaya M, Finkbeiner WE, Chun SY, Widdicombe JH. Differentiated structure and function of cultures from human tracheal epithelium. Am J Physiol. 1992 Jun; 262(6 Pt 1):L713-24. PMID: 1616056.
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    80. Finkbeiner WE, Widdicombe JH, Hu L, Basbaum CB. Bovine tracheal serous cell secretion: role of cAMP and cAMP-dependent protein kinase. Am J Physiol. 1992 May; 262(5 Pt 1):L574-81. PMID: 1375440.
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    81. Kondo M, Finkbeiner WE, Widdicombe JH. Changes in permeability of dog tracheal epithelium in response to hydrostatic pressure. Am J Physiol. 1992 Feb; 262(2 Pt 1):L176-82. PMID: 1539675.
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    82. Hartmann T, Kondo M, Mochizuki H, Verkman AS, Widdicombe JH. Calcium-dependent regulation of Cl secretion in tracheal epithelium. Am J Physiol. 1992 Feb; 262(2 Pt 1):L163-8. PMID: 1311517.
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    83. Mochizuki H, Chao AC, Widdicombe JH. Arachidonic acid inhibits Cl secretion in cultures of dog tracheal epithelium. Life Sci. 1992; 50(15):1129-35. PMID: 1313520.
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    84. Widdicombe JH, Wine JJ. The basic defect in cystic fibrosis. Trends Biochem Sci. 1991 Dec; 16(12):474-7. PMID: 1723552.
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    85. Yamaya M, Finkbeiner WE, Widdicombe JH. Altered ion transport by tracheal glands in cystic fibrosis. Am J Physiol. 1991 Dec; 261(6 Pt 1):L491-4. PMID: 1767868.
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    86. Yamaya M, Finkbeiner WE, Widdicombe JH. Ion transport by cultures of human tracheobronchial submucosal glands. Am J Physiol. 1991 Dec; 261(6 Pt 1):L485-90. PMID: 1767867.
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    87. Katayama Y, Widdicombe JH. Halide transport in Xenopus oocytes. J Physiol. 1991 Nov; 443:587-99. PMID: 1822540.
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    88. Fong P, Chao AC, Widdicombe JH. Potassium dependence of Na-Cl cotransport in dog tracheal epithelium. Am J Physiol. 1991 Oct; 261(4 Pt 1):L290-5. PMID: 1928364.
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    89. Kondo M, Finkbeiner WE, Widdicombe JH. Simple technique for culture of highly differentiated cells from dog tracheal epithelium. Am J Physiol. 1991 Aug; 261(2 Pt 1):L106-17. PMID: 1651662.
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    90. Shen BQ, Yang CM, Widdicombe JH. Rapid procedure for obtaining tracheal apical membranes. Am J Physiol. 1991 Aug; 261(2 Pt 1):L102-5. PMID: 1651661.
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    91. Widdicombe JH, Kondo M, Mochizuki H. Regulation of airway mucosal ion transport. Int Arch Allergy Appl Immunol. 1991; 94(1-4):56-61. PMID: 1718899.
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    92. Wine JJ, Brayden DJ, Hagiwara G, Krouse ME, Law TC, Müller UJ, Solc CK, Ward CL, Widdicombe JH, Xia Y. Cystic fibrosis, the CFTR, and rectifying Cl- channels. Adv Exp Med Biol. 1991; 290:253-69; discussion 269-72. PMID: 1719763.
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    93. Chapman DL, Widdicombe JH, Bland RD. Developmental differences in rabbit lung epithelial cell Na(+)-K(+)-ATPase. Am J Physiol. 1990 Dec; 259(6 Pt 1):L481-7. PMID: 2175558.
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    94. Widdicombe JH. Role of the epithelium in airway hyperreactivity. Nihon Kyobu Shikkan Gakkai Zasshi. 1990 Oct; 28(10):1272-4. PMID: 2273654.
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    95. Gruenert DC, Basbaum CB, Widdicombe JH. Long-term culture of normal and cystic fibrosis epithelial cells grown under serum-free conditions. In Vitro Cell Dev Biol. 1990 Apr; 26(4):411-8. PMID: 1693142.
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    96. Widdicombe JH. Use of cultured airway epithelial cells in studies of ion transport. Am J Physiol. 1990 Feb; 258(2 Pt 1):L13-8. PMID: 2407138.
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    97. Chao AC, Widdicombe JH, Verkman AS. Chloride conductive and cotransport mechanisms in cultures of canine tracheal epithelial cells measured by an entrapped fluorescent indicator. J Membr Biol. 1990 Feb; 113(3):193-202. PMID: 2335807.
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    98. Widdicombe JH, Ueki IF, Emery D, Margolskee D, Yergey J, Nadel JA. Release of cyclooxygenase products from primary cultures of tracheal epithelia of dog and human. Am J Physiol. 1989 Dec; 257(6 Pt 1):L361-5. PMID: 2514604.
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    99. Widdicombe JH. Airway diseases: role of epithelium and inflammatory peptides. Am J Physiol. 1989 Aug; 257(2 Pt 1):L144-6. PMID: 2764116.
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    100. Verkman AS, Takla R, Sefton B, Basbaum C, Widdicombe JH. Quantitative fluorescence measurement of chloride transport mechanisms in phospholipid vesicles. Biochemistry. 1989 May 16; 28(10):4240-4. PMID: 2765484.
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    101. Fong P, Illsley NP, Widdicombe JH, Verkman AS. Chloride transport in apical membrane vesicles from bovine tracheal epithelium: characterization using a fluorescent indicator. J Membr Biol. 1988 Sep; 104(3):233-9. PMID: 3210223.
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    102. Tamaoki J, Ueki IF, Widdicombe JH, Nadel JA. Stimulation of Cl secretion by neurokinin A and neurokinin B in canine tracheal epithelium. Am Rev Respir Dis. 1988 Apr; 137(4):899-902. PMID: 2833141.
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    103. Mrsny RJ, Birrell GB, Volwerk JJ, Widdicombe JH, Griffith OH. A novel approach to the ultrastructural localization of cell surface receptors: affinity-gold labeling of Na, K-ATPase. Eur J Cell Biol. 1988 Feb; 45(2):200-8. PMID: 2835236.
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    104. Jacoby DB, Ueki IF, Widdicombe JH, Loegering DA, Gleich GJ, Nadel JA. Effect of human eosinophil major basic protein on ion transport in dog tracheal epithelium. Am Rev Respir Dis. 1988 Jan; 137(1):13-6. PMID: 3422142.
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    105. Barthelson R, Widdicombe J. Cyclic adenosine monophosphate-dependent kinase in cystic fibrosis tracheal epithelium. J Clin Invest. 1987 Dec; 80(6):1799-802. PMID: 3680529.
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    107. Drazen JM, Boushey HA, Holgate ST, Kaliner M, O'Byrne P, Valentine M, Widdicombe JH, Woolcock A. The pathogenesis of severe asthma: a consensus report from the Workshop on Pathogenesis. J Allergy Clin Immunol. 1987 Sep; 80(3 Pt 2):428-37. PMID: 3624698.
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    108. Ferrara N, Fujii DK, Goldsmith PC, Widdicombe JH, Weiner RI. Transport epithelial characteristics of cultured bovine pituitary follicular cells. Am J Physiol. 1987 Mar; 252(3 Pt 1):E304-12. PMID: 2881486.
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    111. Widdicombe JH. Altered chloride transport of tracheal epithelium in cystic fibrosis. Prog Clin Biol Res. 1987; 254:115-26. PMID: 2448821.
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    113. Corrales RJ, Coleman DL, Jacoby DB, Leikauf GD, Hahn HL, Nadel JA, Widdicombe JH. Ion transport across cat and ferret tracheal epithelia. J Appl Physiol (1985). 1986 Sep; 61(3):1065-70. PMID: 3759745.
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    114. Widdicombe JH. Ion transport by tracheal epithelial cells in culture. Clin Chest Med. 1986 Jun; 7(2):299-305. PMID: 3522074.
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    115. Leikauf GD, Ueki IF, Widdicombe JH, Nadel JA. Alteration of chloride secretion across canine tracheal epithelium by lipoxygenase products of arachidonic acid. Am J Physiol. 1986 Jan; 250(1 Pt 2):F47-53. PMID: 3079967.
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    116. Widdicombe JH, Gashi AA, Basbaum CB, Nathanson IT. Structural changes associated with fluid absorption by dog tracheal epithelium. Exp Lung Res. 1986; 10(1):57-69. PMID: 3948811.
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    117. Widdicombe JH, Welsh MJ, Finkbeiner WE. Cystic fibrosis decreases the apical membrane chloride permeability of monolayers cultured from cells of tracheal epithelium. Proc Natl Acad Sci U S A. 1985 Sep; 82(18):6167-71. PMID: 3862125.
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    118. Widdicombe JH, Coleman DL, Finkbeiner WE, Tuet IK. Electrical properties of monolayers cultured from cells of human tracheal mucosa. J Appl Physiol (1985). 1985 May; 58(5):1729-35. PMID: 2581929.
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    119. Widdicombe JH, Basbaum CB, Highland E. Sodium-pump density of cells from dog tracheal mucosa. Am J Physiol. 1985 May; 248(5 Pt 1):C389-98. PMID: 2986461.
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    120. Leikauf GD, Ueki IF, Nadel JA, Widdicombe JH. Bradykinin stimulates Cl secretion and prostaglandin E2 release by canine tracheal epithelium. Am J Physiol. 1985 Jan; 248(1 Pt 2):F48-55. PMID: 3918456.
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    121. Corrales RJ, Nadel JA, Widdicombe JH. Source of the fluid component of secretions from tracheal submucosal glands in cats. J Appl Physiol Respir Environ Exerc Physiol. 1984 Apr; 56(4):1076-82. PMID: 6725054.
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    122. Coleman DL, Tuet IK, Widdicombe JH. Electrical properties of dog tracheal epithelial cells grown in monolayer culture. Am J Physiol. 1984 Mar; 246(3 Pt 1):C355-9. PMID: 6367482.
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    123. Basbaum CB, Grillo MA, Widdicombe JH. Muscarinic receptors: evidence for a nonuniform distribution in tracheal smooth muscle and exocrine glands. J Neurosci. 1984 Feb; 4(2):508-20. PMID: 6699685.
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    124. Widdicombe JH. Fluid transport across airway epithelia. Ciba Found Symp. 1984; 109:109-20. PMID: 6569835.
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    125. Nathanson I, Widdicombe JH, Barnes PJ. Effect of vasoactive intestinal peptide on ion transport across dog tracheal epithelium. J Appl Physiol Respir Environ Exerc Physiol. 1983 Dec; 55(6):1844-8. PMID: 6662775.
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    126. Widdicombe JH, Nathanson IT, Highland E. Effects of "loop" diuretics on ion transport by dog tracheal epithelium. Am J Physiol. 1983 Nov; 245(5 Pt 1):C388-96. PMID: 6638166.
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    127. Nathanson I, Widdicombe JH, Nadel JA. Effects of amphotericin B on ion and fluid movement across dog tracheal epithelium. J Appl Physiol Respir Environ Exerc Physiol. 1983 Oct; 55(4):1257-61. PMID: 6629959.
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    128. Mason RJ, Williams MC, Widdicombe JH. Fluid and electrolyte transport across monolayers of alveolar type II cells in vitro. Am Rev Respir Dis. 1983 May; 127(5 Pt 2):S24-8. PMID: 6846947.
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    129. Basbaum CB, Barnes PJ, Grillo MA, Widdicombe JH, Nadel JA. Adrenergic and cholinergic receptors in submucosal glands of the ferret trachea: autoradiographic localization. Eur J Respir Dis Suppl. 1983; 128 (Pt 2):433-5. PMID: 6578099.
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    130. Nathanson I, Widdicombe JH, Davis B. Electrical properties of tracheal epithelium in cystic fibrosis. N Engl J Med. 1982 Dec 30; 307(27):1707-8. PMID: 7144871.
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    131. Mason RJ, Williams MC, Widdicombe JH, Sanders MJ, Misfeldt DS, Berry LC. Transepithelial transport by pulmonary alveolar type II cells in primary culture. Proc Natl Acad Sci U S A. 1982 Oct; 79(19):6033-7. PMID: 6964398.
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    132. Widdicombe JH, Basbaum CB, Highland E. Ion contents and other properties of isolated cells from dog tracheal epithelium. Am J Physiol. 1981 Nov; 241(5):C184-92. PMID: 7304731.
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    133. Widdicombe JH, Welsh MJ. Ion transport by dog tracheal epithelium. Fed Proc. 1980 Nov; 39(13):3062-6. PMID: 6253330.
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    134. Welsh MJ, Widdicombe JH, Nadel JA. Fluid transport across the canine tracheal epithelium. J Appl Physiol Respir Environ Exerc Physiol. 1980 Nov; 49(5):905-9. PMID: 7429914.
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    135. Welsh MJ, Widdicombe JH. Pathways of ion movement in the canine tracheal epithelium. Am J Physiol. 1980 Sep; 239(3):F215-21. PMID: 7435560.
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    136. Widdicombe JH, Welsh MJ. Anion selectivity of the chloride-transport process in dog tracheal epithelium. Am J Physiol. 1980 Sep; 239(3):C112-7. PMID: 7435549.
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    137. Widdicombe JH, Brading AF. A possible role of linked Na and Cl movement in active Cl uptake in smooth muscle. Pflugers Arch. 1980 Jul; 386(1):35-7. PMID: 7191961.
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    138. Widdicombe JH, Paton DM. The uptake and efflux of alpha-aminoisobutyric acid by the smooth muscle of the guinea pig's taenia coli. Can J Physiol Pharmacol. 1979 Oct; 57(10):1114-21. PMID: 509365.
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    139. Widdicombe JH, Ueki IF, Bruderman I, Nadel JA. The effects of sodium substitution and ouabain on ion transport by dog tracheal epithelium. Am Rev Respir Dis. 1979 Aug; 120(2):385-92. PMID: 475157.
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    140. Widdicombe JH, Basbaum CB, Yee JY. Localization of Na pumps in the tracheal epithelium of the dog. J Cell Biol. 1979 Aug; 82(2):380-90. PMID: 225337.
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    141. Widdicombe JH, Paton DM. Fine structure and innervation of smooth muscle in the monkey oviduct. Gynecol Obstet Invest. 1979; 10(5):221-30. PMID: 119676.
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    142. Paton DM, Widdicombe JH, Rheaume DE, Johns A. The role of the adrenergic innervation of the oviduct in the regulation of mammalian ovum transport. Pharmacol Rev. 1977 Jun; 29(2):67-102. PMID: 353829.
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    143. Widdicombe JH, Johns A, Paton DM. Responses of the monkey oviduct to transmural electrical stimulation and to drugs. J Reprod Fertil. 1977 May; 50(1):141-4. PMID: 405490.
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    144. Widdicombe JH. Ouabain-sensitive ion fluxes in the smooth muscle of the guinea-pig's taenia coli. J Physiol. 1977 Apr; 266(2):235-54. PMID: 857001.
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    145. Brading AF, Widdicombe JH. The use of lanthanum to estimate the numbers of extracellular cation-exchanging sites in the guinea-pig's taenia coli, and its effects on transmembrane monovalent ion movements. J Physiol. 1977 Apr; 266(2):255-73. PMID: 857002.
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    146. Widdicombe JH. Proceedings: The effect of lanthanum on ion content and movement in the guinea-pig's taenia coli. J Physiol. 1974 Sep; 241(2):106P-107P. PMID: 4443902.
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    147. Brading AF, Widdicombe JH. An estimate of sodium-potassium pump activity and the number of pump sites in the smooth muscle of the guinea-pig taenia coli, using (3H)ouabain. J Physiol. 1974 Apr; 238(2):235-49. PMID: 4840873.
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