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Reen Wu

Title(s)Professor, Pulmonary, Critical Care, and Sleep Medicine
SchoolUniversity of California, Davis
Phone530-752-2648
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wang CN, Lin YC, Chang BC, Chen CH, Wu R, Lee CC. Targeting the phosphorylation site of myristoylated alanine-rich C kinase substrate alleviates symptoms in a murine model of steroid-resistant asthma. Br J Pharmacol. 2019 Apr; 176(8):1122-1134. PMID: 30706455.
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    2. Tsai HC, Velichko S, Lee S, Wu R. Cholera toxin enhances interleukin-17A production in both CD4+ and CD8+ cells via a cAMP/protein kinase A-mediated interleukin-17A promoter activation. Immunology. 2018 07; 154(3):500-509. PMID: 29377102.
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    3. Chang WH, Thai P, Xu J, Yang DC, Wu R, Chen CH. Cigarette Smoke Regulates the Competitive Interactions between NRF2 and BACH1 for Heme Oxygenase-1 Induction. Int J Mol Sci. 2017 Nov 10; 18(11). PMID: 29125538.
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    4. Chen CH, Fong LWR, Yu E, Wu R, Trott JF, Weiss RH. Upregulation of MARCKS in kidney cancer and its potential as a therapeutic target. Oncogene. 2017 06 22; 36(25):3588-3598. PMID: 28166200.
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    5. Velichko S, Zhou X, Zhu L, Anderson JD, Wu R, Chen Y. A Novel Nuclear Function for the Interleukin-17 Signaling Adaptor Protein Act1. PLoS One. 2016; 11(10):e0163323. PMID: 27723765.
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    6. Chen CH, Chang WH, Su KY, Ku WH, Chang GC, Hong QS, Hsiao YJ, Chen HC, Chen HY, Wu R, Yang PC, Chen JJ, Yu SL. HLJ1 is an endogenous Src inhibitor suppressing cancer progression through dual mechanisms. Oncogene. 2016 10 27; 35(43):5674-5685. PMID: 27065329.
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    7. Chen YC, Statt S, Wu R, Chang HT, Liao JW, Wang CN, Shyu WC, Lee CC. High mobility group box 1-induced epithelial mesenchymal transition in human airway epithelial cells. Sci Rep. 2016 Jan 07; 6:18815. PMID: 26739898.
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    8. Lee CC, Lee YL, Wang CN, Tsai HC, Chiu CL, Liu LF, Lin HY, Wu R. Polygonum multiflorum Decreases Airway Allergic Symptoms in a Murine Model of Asthma. Am J Chin Med. 2016; 44(1):133-47. PMID: 26916919.
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    9. Statt S, Ruan JW, Hung LY, Chang CY, Huang CT, Lim JH, Li JD, Wu R, Kao CY. Statin-conferred enhanced cellular resistance against bacterial pore-forming toxins in airway epithelial cells. Am J Respir Cell Mol Biol. 2015 Nov; 53(5):689-702. PMID: 25874372.
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    10. Chen CH, Cheng CT, Yuan Y, Zhai J, Arif M, Fong LW, Wu R, Ann DK. Elevated MARCKS phosphorylation contributes to unresponsiveness of breast cancer to paclitaxel treatment. Oncotarget. 2015 Jun 20; 6(17):15194-208. PMID: 26015406.
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    11. Statt S, Ruan JW, Huang CT, Wu R, Kao CY. Lipidome and transcriptome profiling of pneumolysin intoxication identifies networks involved in statin-conferred protection of airway epithelial cells. Sci Rep. 2015 May 29; 5:10624. PMID: 26023727.
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    12. Lee JG, Wu R. Erlotinib-cisplatin combination inhibits growth and angiogenesis through c-MYC and HIF-1a in EGFR-mutated lung cancer in vitro and in vivo. Neoplasia. 2015 Feb; 17(2):190-200. PMID: 25748238.
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    13. Zhu L, Di PY, Wu R, Pinkerton KE, Chen Y. Repression of CC16 by cigarette smoke (CS) exposure. PLoS One. 2015; 10(1):e0116159. PMID: 25635997.
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    14. Tsai HC, Wu R. Mechanisms of Cholera Toxin in the Modulation of TH17 Responses. Crit Rev Immunol. 2015; 35(2):135-52. PMID: 26351147.
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    15. Chen CH, Statt S, Chiu CL, Thai P, Arif M, Adler KB, Wu R. Targeting myristoylated alanine-rich C kinase substrate phosphorylation site domain in lung cancer. Mechanisms and therapeutic implications. Am J Respir Crit Care Med. 2014 Nov 15; 190(10):1127-38. PMID: 25318062.
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    16. Oslund KL, Zhou X, Lee B, Zhu L, Duong T, Shih R, Baumgarth N, Hung LY, Wu R, Chen Y. Synergistic up-regulation of CXCL10 by virus and IFN ? in human airway epithelial cells. PLoS One. 2014; 9(7):e100978. PMID: 25033426.
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    17. Chen CH, Chiu CL, Adler KB, Wu R. A novel predictor of cancer malignancy: up-regulation of myristoylated alanine-rich C kinase substrate phosphorylation in lung cancer. Am J Respir Crit Care Med. 2014 Apr 15; 189(8):1002-4. PMID: 24735036.
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    18. Kusagaya H, Fujisawa T, Yamanaka K, Mori K, Hashimoto D, Enomoto N, Inui N, Nakamura Y, Wu R, Maekawa M, Suda T, Chida K. Toll-like receptor-mediated airway IL-17C enhances epithelial host defense in an autocrine/paracrine manner. Am J Respir Cell Mol Biol. 2014 Jan; 50(1):30-9. PMID: 23944933.
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    19. Tsai HC, Wu R. Cholera toxin directly enhances IL-17A production from human CD4+ T cells. J Immunol. 2013 Oct 15; 191(8):4095-102. PMID: 24043897.
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    20. Chen CH, Thai P, Yoneda K, Adler KB, Yang PC, Wu R. A peptide that inhibits function of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) reduces lung cancer metastasis. Oncogene. 2014 Jul 10; 33(28):3696-706. PMID: 23955080.
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    21. Thai P, Statt S, Chen CH, Liang E, Campbell C, Wu R. Characterization of a novel long noncoding RNA, SCAL1, induced by cigarette smoke and elevated in lung cancer cell lines. Am J Respir Cell Mol Biol. 2013 Aug; 49(2):204-11. PMID: 23672216.
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    22. Morgan-Bathke M, Lin HH, Chibly AM, Zhang W, Sun X, Chen CH, Flodby P, Borok Z, Wu R, Arnett D, Klein RR, Ann DK, Limesand KH. Deletion of ATG5 shows a role of autophagy in salivary homeostatic control. J Dent Res. 2013 Oct; 92(10):911-7. PMID: 23884556.
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    23. Tsai HC, Velichko S, Hung LY, Wu R. IL-17A and Th17 cells in lung inflammation: an update on the role of Th17 cell differentiation and IL-17R signaling in host defense against infection. Clin Dev Immunol. 2013; 2013:267971. PMID: 23956759.
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    24. Lee JG, Wu R. Combination erlotinib-cisplatin and Atg3-mediated autophagy in erlotinib resistant lung cancer. PLoS One. 2012; 7(10):e48532. PMID: 23119048.
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    25. Plopper CG, Joad JP, Miller LA, Schelegle ES, Fanucchi MV, Van Winkle LS, Tyler NK, Avdalovic MV, Evans MJ, Lasley WL, Buckpitt AR, Pinkerton KE, Tarkington BK, Davis S, Nishio SJ, Gershwin LJ, Wu R, Hyde DM. Lung effects of inhaled corticosteroids in a rhesus monkey model of childhood asthma. Clin Exp Allergy. 2012 Jul; 42(7):1104-18. PMID: 22702509.
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    26. Zeki AA, Thai P, Kenyon NJ, Wu R. Differential effects of simvastatin on IL-13-induced cytokine gene expression in primary mouse tracheal epithelial cells. Respir Res. 2012 May 14; 13:38. PMID: 22583375.
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    27. Lee YC, Oslund KL, Thai P, Velichko S, Fujisawa T, Duong T, Denison MS, Wu R. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced MUC5AC expression: aryl hydrocarbon receptor-independent/EGFR/ERK/p38-dependent SP1-based transcription. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):270-6. PMID: 20971882.
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    28. Fujisawa T, Chang MM, Velichko S, Thai P, Hung LY, Huang F, Phuong N, Chen Y, Wu R. NF-?B mediates IL-1ß- and IL-17A-induced MUC5B expression in airway epithelial cells. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):246-52. PMID: 20935193.
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    29. Oslund KL, Adamson G, Wu R. Evaluation of MUC5AC expression and upregulation in airway epithelial cells of horses. Am J Vet Res. 2010 Jun; 71(6):690-6. PMID: 20513186.
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    30. Fujisawa T, Velichko S, Thai P, Hung LY, Huang F, Wu R. Regulation of airway MUC5AC expression by IL-1beta and IL-17A; the NF-kappaB paradigm. J Immunol. 2009 Nov 15; 183(10):6236-43. PMID: 19841186.
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    31. Huang F, Wachi S, Thai P, Loukoianov A, Tan KH, Forteza RM, Wu R. Potentiation of IL-19 expression in airway epithelia by IL-17A and IL-4/IL-13: important implications in asthma. J Allergy Clin Immunol. 2008 Jun; 121(6):1415-21, 1421.e1-3. PMID: 18539194.
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    32. Kao CY, Kim C, Huang F, Wu R. Requirements for two proximal NF-kappaB binding sites and IkappaB-zeta in IL-17A-induced human beta-defensin 2 expression by conducting airway epithelium. J Biol Chem. 2008 May 30; 283(22):15309-18. PMID: 18362142.
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    33. Lee YC, Chuang CY, Lee PK, Lee JS, Harper RW, Buckpitt AB, Wu R, Oslund K. TRX-ASK1-JNK signaling regulation of cell density-dependent cytotoxicity in cigarette smoke-exposed human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2008 May; 294(5):L921-31. PMID: 18281606.
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    34. Thai P, Loukoianov A, Wachi S, Wu R. Regulation of airway mucin gene expression. Annu Rev Physiol. 2008; 70:405-29. PMID: 17961085.
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    35. Hung LY, Velichko S, Huang F, Thai P, Wu R. Regulation of airway innate and adaptive immune responses: the IL-17 paradigm. Crit Rev Immunol. 2008; 28(4):269-79. PMID: 19166380.
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    36. Zhu L, Pi J, Wachi S, Andersen ME, Wu R, Chen Y. Identification of Nrf2-dependent airway epithelial adaptive response to proinflammatory oxidant-hypochlorous acid challenge by transcription profiling. Am J Physiol Lung Cell Mol Physiol. 2008 Mar; 294(3):L469-77. PMID: 18156441.
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    37. Huang F, Kao CY, Wachi S, Thai P, Ryu J, Wu R. Requirement for both JAK-mediated PI3K signaling and ACT1/TRAF6/TAK1-dependent NF-kappaB activation by IL-17A in enhancing cytokine expression in human airway epithelial cells. J Immunol. 2007 Nov 15; 179(10):6504-13. PMID: 17982039.
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    38. Wu DY, Wu R, Chen Y, Tarasova N, Chang MM. PMA stimulates MUC5B gene expression through an Sp1-based mechanism in airway epithelial cells. Am J Respir Cell Mol Biol. 2007 Nov; 37(5):589-97. PMID: 17600309.
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    39. Yuan-Chen Wu D, Wu R, Reddy SP, Lee YC, Chang MM. Distinctive epidermal growth factor receptor/extracellular regulated kinase-independent and -dependent signaling pathways in the induction of airway mucin 5B and mucin 5AC expression by phorbol 12-myristate 13-acetate. Am J Pathol. 2007 Jan; 170(1):20-32. PMID: 17200179.
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    40. Plopper CG, Smiley-Jewell SM, Miller LA, Fanucchi MV, Evans MJ, Buckpitt AR, Avdalovic M, Gershwin LJ, Joad JP, Kajekar R, Larson S, Pinkerton KE, Van Winkle LS, Schelegle ES, Pieczarka EM, Wu R, Hyde DM. Asthma/allergic airways disease: does postnatal exposure to environmental toxicants promote airway pathobiology? Toxicol Pathol. 2007 Jan; 35(1):97-110. PMID: 17325978.
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    41. Wu R. [Regulation of mucosal immunity by airway epithelium: the interleukin-17A paradigm]. Zhonghua Yi Xue Za Zhi. 2006 Nov 07; 86(41):2893-6. PMID: 17288784.
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    42. Kao CY, Huang F, Chen Y, Thai P, Wachi S, Kim C, Tam L, Wu R. Up-regulation of CC chemokine ligand 20 expression in human airway epithelium by IL-17 through a JAK-independent but MEK/NF-kappaB-dependent signaling pathway. J Immunol. 2005 Nov 15; 175(10):6676-85. PMID: 16272323.
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    43. Chen Y, Hamati E, Lee PK, Lee WM, Wachi S, Schnurr D, Yagi S, Dolganov G, Boushey H, Avila P, Wu R. Rhinovirus induces airway epithelial gene expression through double-stranded RNA and IFN-dependent pathways. Am J Respir Cell Mol Biol. 2006 Feb; 34(2):192-203. PMID: 16210696.
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    44. Wachi S, Yoneda K, Wu R. Interactome-transcriptome analysis reveals the high centrality of genes differentially expressed in lung cancer tissues. Bioinformatics. 2005 Dec 01; 21(23):4205-8. PMID: 16188928.
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    45. Thai P, Chen Y, Dolganov G, Wu R. Differential regulation of MUC5AC/Muc5ac and hCLCA-1/mGob-5 expression in airway epithelium. Am J Respir Cell Mol Biol. 2005 Dec; 33(6):523-30. PMID: 16151054.
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    46. Harper RW, Xu C, Eiserich JP, Chen Y, Kao CY, Thai P, Setiadi H, Wu R. Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium. FEBS Lett. 2005 Aug 29; 579(21):4911-7. PMID: 16111680.
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    47. Harper R, Xu C, Di P, Chen Y, Privalsky M, Wu R. Identification of a novel MAGE D2 antisense RNA transcript in human tissues. Biochem Biophys Res Commun. 2004 Nov 05; 324(1):199-204. PMID: 15465002.
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    48. Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R. IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. J Immunol. 2004 Sep 01; 173(5):3482-91. PMID: 15322213.
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    49. Oslund KL, Miller LA, Usachenko JL, Tyler NK, Wu R, Hyde DM. Oxidant-injured airway epithelial cells upregulate thioredoxin but do not produce interleukin-8. Am J Respir Cell Mol Biol. 2004 May; 30(5):597-604. PMID: 15096327.
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    50. Serikov VB, Choi H, Schmiel K, Skaggs C, Fleming NW, Wu R, Widdicombe JH. Endotoxin induces leukocyte transmigration and changes in permeability of the airway epithelium via protein-kinase C and extracellular regulated kinase activation. J Endotoxin Res. 2004; 10(1):55-65. PMID: 15025824.
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    51. Schelegle ES, Miller LA, Gershwin LJ, Fanucchi MV, Van Winkle LS, Gerriets JE, Walby WF, Mitchell V, Tarkington BK, Wong VJ, Baker GL, Pantle LM, Joad JP, Pinkerton KE, Wu R, Evans MJ, Hyde DM, Plopper CG. Repeated episodes of ozone inhalation amplifies the effects of allergen sensitization and inhalation on airway immune and structural development in Rhesus monkeys. Toxicol Appl Pharmacol. 2003 Aug 15; 191(1):74-85. PMID: 12915105.
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    52. Yoneda K, Chang MM, Chmiel K, Chen Y, Wu R. Application of high-density DNA microarray to study smoke- and hydrogen peroxide-induced injury and repair in human bronchial epithelial cells. J Am Soc Nephrol. 2003 Aug; 14(8 Suppl 3):S284-9. PMID: 12874447.
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    53. Chen Y, Zhao YH, Kalaslavadi TB, Hamati E, Nehrke K, Le AD, Ann DK, Wu R. Genome-wide search and identification of a novel gel-forming mucin MUC19/Muc19 in glandular tissues. Am J Respir Cell Mol Biol. 2004 Feb; 30(2):155-65. PMID: 12882755.
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    54. Serikov VB, Choi H, Chmiel KJ, Wu R, Widdicombe JH. Activation of extracellular regulated kinases is required for the increase in airway epithelial permeability during leukocyte transmigration. Am J Respir Cell Mol Biol. 2004 Mar; 30(3):261-70. PMID: 12842851.
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    55. Chen Y, Thai P, Zhao YH, Ho YS, DeSouza MM, Wu R. Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop. J Biol Chem. 2003 May 09; 278(19):17036-43. PMID: 12624114.
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    56. Kao CY, Chen Y, Zhao YH, Wu R. ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes. Am J Respir Cell Mol Biol. 2003 Jul; 29(1):71-80. PMID: 12600824.
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    57. Lau D, Guo L, Chan A, Wu R. SPR1. An early molecular marker for bronchial carcinogenesis. Methods Mol Med. 2003; 75:397-403. PMID: 12407755.
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    58. Di YP, Harper R, Zhao Y, Pahlavan N, Finkbeiner W, Wu R. Molecular cloning and characterization of spurt, a human novel gene that is retinoic acid-inducible and encodes a secretory protein specific in upper respiratory tracts. J Biol Chem. 2003 Jan 10; 278(2):1165-73. PMID: 12409287.
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    59. Krig SR, Chandraratna RA, Chang MM, Wu R, Rice RH. Gene-specific TCDD suppression of RARalpha- and RXR-mediated induction of tissue transglutaminase. Toxicol Sci. 2002 Jul; 68(1):102-8. PMID: 12075115.
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    60. Chang WH, Reddy SP, Di YP, Yoneda K, Harper R, Wu R. Regulation of thioredoxin gene expression by vitamin A in human airway epithelial cells. Am J Respir Cell Mol Biol. 2002 May; 26(5):627-35. PMID: 11970916.
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    61. Groneberg DA, Eynott PR, Lim S, Oates T, Wu R, Carlstedt I, Roberts P, McCann B, Nicholson AG, Harrison BD, Chung KF. Expression of respiratory mucins in fatal status asthmaticus and mild asthma. Histopathology. 2002 Apr; 40(4):367-73. PMID: 11943022.
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    62. Groneberg DA, Eynott PR, Oates T, Lim S, Wu R, Carlstedt I, Nicholson AG, Chung KF. Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung. Respir Med. 2002 Feb; 96(2):81-6. PMID: 11860173.
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    63. Yoneda K, Peck K, Chang MM, Chmiel K, Sher YP, Chen J, Yang PC, Chen Y, Wu R. Development of high-density DNA microarray membrane for profiling smoke- and hydrogen peroxide-induced genes in a human bronchial epithelial cell line. Am J Respir Crit Care Med. 2001 Nov 15; 164(10 Pt 2):S85-9. PMID: 11734474.
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    64. Chen Y, Zhao YH, Di YP, Wu R. Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5'-flanking region. Am J Respir Cell Mol Biol. 2001 Nov; 25(5):542-53. PMID: 11713095.
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    65. Chen Y, Zhao YH, Wu R. Differential regulation of airway mucin gene expression and mucin secretion by extracellular nucleotide triphosphates. Am J Respir Cell Mol Biol. 2001 Oct; 25(4):409-17. PMID: 11694445.
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    66. Chen Y, Zhao YH, Wu R. In silico cloning of mouse Muc5b gene and upregulation of its expression in mouse asthma model. Am J Respir Crit Care Med. 2001 Sep 15; 164(6):1059-66. PMID: 11587997.
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    67. Harper R, Wu K, Chang MM, Yoneda K, Pan R, Reddy SP, Wu R. Activation of nuclear factor-kappa b transcriptional activity in airway epithelial cells by thioredoxin but not by N-acetyl-cysteine and glutathione. Am J Respir Cell Mol Biol. 2001 Aug; 25(2):178-85. PMID: 11509327.
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    68. Chen JJ, Peck K, Hong TM, Yang SC, Sher YP, Shih JY, Wu R, Cheng JL, Roffler SR, Wu CW, Yang PC. Global analysis of gene expression in invasion by a lung cancer model. Cancer Res. 2001 Jul 01; 61(13):5223-30. PMID: 11431363.
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    69. Wu R, Chen Y. Fishing for inflammatory cytokine-inducible genes with an old trick. Am J Physiol Lung Cell Mol Physiol. 2001 May; 280(5):L839-40. PMID: 11290505.
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    70. Soref CM, Di YP, Hayden L, Zhao YH, Satre MA, Wu R. Characterization of a novel airway epithelial cell-specific short chain alcohol dehydrogenase/reductase gene whose expression is up-regulated by retinoids and is involved in the metabolism of retinol. J Biol Chem. 2001 Jun 29; 276(26):24194-202. PMID: 11304534.
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    71. Patterson T, Vuong H, Liaw YS, Wu R, Kalvakolanu DV, Reddy SP. Mechanism of repression of squamous differentiation marker, SPRR1B, in malignant bronchial epithelial cells: role of critical TRE-sites and its transacting factors. Oncogene. 2001 Feb 01; 20(5):634-44. PMID: 11313996.
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    72. Ordoñez CL, Khashayar R, Wong HH, Ferrando R, Wu R, Hyde DM, Hotchkiss JA, Zhang Y, Novikov A, Dolganov G, Fahy JV. Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. Am J Respir Crit Care Med. 2001 Feb; 163(2):517-23. PMID: 11179133.
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    73. Schelegle ES, Gershwin LJ, Miller LA, Fanucchi MV, Van Winkle LS, Gerriets JP, Walby WF, Omlor AM, Buckpitt AR, Tarkington BK, Wong VJ, Joad JP, Pinkerton KB, Wu R, Evans MJ, Hyde DM, Plopper CG. Allergic asthma induced in rhesus monkeys by house dust mite (Dermatophagoides farinae). Am J Pathol. 2001 Jan; 158(1):333-41. PMID: 11141508.
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    74. Chang MM, Juarez M, Hyde DM, Wu R. Mechanism of dexamethasone-mediated interleukin-8 gene suppression in cultured airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2001 Jan; 280(1):L107-15. PMID: 11133500.
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    75. Vuong H, Patterson T, Shapiro P, Kalvakolanu DV, Wu R, Ma WY, Dong Z, Kleeberger SR, Reddy SP. Phorbol ester-induced expression of airway squamous cell differentiation marker, SPRR1B, is regulated by protein kinase Cdelta /Ras/MEKK1/MKK1-dependent/AP-1 signal transduction pathway. J Biol Chem. 2000 Oct 13; 275(41):32250-9. PMID: 10918063.
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    76. Deng J, Chen Y, Wu R. Induction of cell cornification and enhanced squamous-cell marker SPRR1 gene expression by phorbol ester are regulated by different signaling pathways in human conducting airway epithelial cells. Am J Respir Cell Mol Biol. 2000 May; 22(5):597-603. PMID: 10783132.
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    77. Chang MM, Harper R, Hyde DM, Wu R. A novel mechanism of retinoic acid-enhanced interleukin-8 gene expression in airway epithelium. Am J Respir Cell Mol Biol. 2000 Apr; 22(4):502-10. PMID: 10745031.
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    78. Wang HC, Zentner MD, Deng HT, Kim KJ, Wu R, Yang PC, Ann DK. Oxidative stress disrupts glucocorticoid hormone-dependent transcription of the amiloride-sensitive epithelial sodium channel alpha-subunit in lung epithelial cells through ERK-dependent and thioredoxin-sensitive pathways. J Biol Chem. 2000 Mar 24; 275(12):8600-9. PMID: 10722699.
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    79. Deng J, Pan R, Wu R. Distinct roles for amino- and carboxyl-terminal sequences of SPRR1 protein in the formation of cross-linked envelopes of conducting airway epithelial cells. J Biol Chem. 2000 Feb 25; 275(8):5739-47. PMID: 10681560.
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    80. Lau D, Xue L, Hu R, Liaw T, Wu R, Reddy S. Expression and regulation of a molecular marker, SPR1, in multistep bronchial carcinogenesis. Am J Respir Cell Mol Biol. 2000 Jan; 22(1):92-6. PMID: 10615070.
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    81. Wu R, Zhao YH, Plopper CG, Chang MM, Chmiel K, Cross JJ, Weir A, Last JA, Tarkington B. Differential expression of stress proteins in nonhuman primate lung and conducting airway after ozone exposure. Am J Physiol. 1999 09; 277(3):L511-22. PMID: 10484458.
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    82. Chang VW, Wu R, Ho YS. Recycling of anion-exchange resins for plasmid DNA purification. Biotechniques. 1999 Jun; 26(6):1056. PMID: 10376139.
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    83. Reddy SP, Konkin T, Wu R. Structure and organization of the genes encoding mouse small proline-rich proteins, mSPRR1A and 1B. Gene. 1998 Dec 11; 224(1-2):59-66. PMID: 9931436.
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    84. Chang MM, Wu R, Plopper CG, Hyde DM. IL-8 is one of the major chemokines produced by monkey airway epithelium after ozone-induced injury. Am J Physiol. 1998 09; 275(3):L524-32. PMID: 9728047.
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    85. Chen JJ, Wu R, Yang PC, Huang JY, Sher YP, Han MH, Kao WC, Lee PJ, Chiu TF, Chang F, Chu YW, Wu CW, Peck K. Profiling expression patterns and isolating differentially expressed genes by cDNA microarray system with colorimetry detection. Genomics. 1998 Aug 01; 51(3):313-24. PMID: 9721201.
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    86. Hu R, Wu R, Deng J, Lau D. A small proline-rich protein, spr1: specific marker for squamous lung carcinoma. Lung Cancer. 1998 Apr; 20(1):25-30. PMID: 9699184.
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    87. Shih JY, Yang SC, Yu CJ, Wu HD, Liaw YS, Wu R, Yang PC. Elevated serum levels of mucin-associated antigen in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 1997 Nov; 156(5):1453-7. PMID: 9372660.
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    88. Wu R, Zhao YH, Chang MM. Growth and differentiation of conducting airway epithelial cells in culture. Eur Respir J. 1997 Oct; 10(10):2398-403. PMID: 9387971.
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    89. Chu YW, Yang PC, Yang SC, Shyu YC, Hendrix MJ, Wu R, Wu CW. Selection of invasive and metastatic subpopulations from a human lung adenocarcinoma cell line. Am J Respir Cell Mol Biol. 1997 Sep; 17(3):353-60. PMID: 9308922.
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    90. Reddy PM, An G, Di YP, Zhao YH, Wu R. Isolation and characterization of nucleolin gene as one of the vitamin A-responsive genes in airway epithelium by a palindromic primer-based mRNA differential display method. Am J Respir Cell Mol Biol. 1996 Sep; 15(3):398-403. PMID: 8810645.
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    91. Spencer JP, Jenner A, Aruoma OI, Cross CE, Wu R, Halliwell B. Oxidative DNA damage in human respiratory tract epithelial cells. Time course in relation to DNA strand breakage. Biochem Biophys Res Commun. 1996 Jul 05; 224(1):17-22. PMID: 8694807.
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    92. Miller LA, Zhao YH, Wu R. Inhibition of TGF-alpha gene expression by vitamin A in airway epithelium. J Clin Invest. 1996 Mar 15; 97(6):1429-35. PMID: 8617875.
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    93. Spencer JP, Jenner A, Chimel K, Aruoma OI, Cross CE, Wu R, Halliwell B. DNA damage in human respiratory tract epithelial cells: damage by gas phase cigarette smoke apparently involves attack by reactive nitrogen species in addition to oxygen radicals. FEBS Lett. 1995 Nov 20; 375(3):179-82. PMID: 7498494.
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    101. Luo G, An G, Wu R. A PCR differential screening method for rapid isolation of clones from a cDNA library. Biotechniques. 1994 Apr; 16(4):670, 673-5. PMID: 8024788.
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    103. Huang TH, Ann DK, Zhang YJ, Chang AT, Crabb JW, Wu R. Control of keratin gene expression by vitamin A in tracheobronchial epithelial cells. Am J Respir Cell Mol Biol. 1994 Feb; 10(2):192-201. PMID: 7509163.
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    105. Tesfaigzi J, Wright PS, Oreffo V, An G, Wu R, Carlson DM. A small proline-rich protein regulated by vitamin A in tracheal epithelial cells is induced in lung tumors. Am J Respir Cell Mol Biol. 1993 Oct; 9(4):434-40. PMID: 8398182.
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    106. Robinson CB, Martin WR, Ratliff JL, Holland PV, Wu R, Cross CE. Elevated levels of serum mucin-associated antigen in adult patients with cystic fibrosis. Am Rev Respir Dis. 1993 Aug; 148(2):385-9. PMID: 8342902.
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    107. Robinson CB, Wu R. Mucin synthesis and secretion by cultured tracheal cells: effects of collagen gel substratum thickness. In Vitro Cell Dev Biol Anim. 1993 Jun; 29A(6):469-77. PMID: 8331031.
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    108. Miller LA, Cheng LZ, Wu R. Inhibition of epidermal growth factor-like growth factor secretion in tracheobronchial epithelial cells by vitamin A. Cancer Res. 1993 Jun 01; 53(11):2527-33. PMID: 8495415.
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    109. An G, Tesfaigzi J, Chuu YJ, Wu R. Isolation and characterization of the human spr1 gene and its regulation of expression by phorbol ester and cyclic AMP. J Biol Chem. 1993 May 25; 268(15):10977-82. PMID: 8388378.
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    110. An G, Wu R. cDNA cloning of a hnRNP A1 isoform and its regulation by retinol in monkey tracheobronchial epithelial cells. Biochim Biophys Acta. 1993 Mar 20; 1172(3):292-300. PMID: 8448206.
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    111. Tang TK, Hong TM, Lin CY, Lai ML, Liu CH, Lo HJ, Wang ME, Chen LB, Chen WT, Ip W. Nuclear proteins of the bovine esophageal epithelium. I. Monoclonal antibody W2 specifically reacts with condensed nuclei of differentiated superficial cells. J Cell Sci. 1993 Feb; 104 ( Pt 2):237-47. PMID: 8505358.
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    112. Yang PC, Luh KT, Wu R, Wu CW. Characterization of the mucin differentiation in human lung adenocarcinoma cell lines. Am J Respir Cell Mol Biol. 1992 Aug; 7(2):161-71. PMID: 1497905.
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    114. Hyde DM, Hubbard WC, Wong V, Wu R, Pinkerton K, Plopper CG. Ozone-induced acute tracheobronchial epithelial injury: relationship to granulocyte emigration in the lung. Am J Respir Cell Mol Biol. 1992 May; 6(5):481-97. PMID: 1581072.
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    115. Plopper C, St George J, Cardoso W, Wu R, Pinkerton K, Buckpitt A. Development of airway epithelium. Patterns of expression for markers of differentiation. Chest. 1992 Mar; 101(3 Suppl):2S-5S. PMID: 1371732.
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    116. An G, Wu R. Thioredoxin gene expression is transcriptionally up-regulated by retinol in monkey conducting airway epithelial cells. Biochem Biophys Res Commun. 1992 Feb 28; 183(1):170-5. PMID: 1543487.
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    117. Wu R, Plopper CG, Cheng PW. Mucin-like glycoprotein secreted by cultured hamster tracheal epithelial cells. Biochemical and immunological characterization. Biochem J. 1991 Aug 01; 277 ( Pt 3):713-8. PMID: 1651700.
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    118. Martin WR, Brown C, Zhang YJ, Wu R. Growth and differentiation of primary tracheal epithelial cells in culture: regulation by extracellular calcium. J Cell Physiol. 1991 Apr; 147(1):138-48. PMID: 2037619.
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    119. Tesfaigzi J, An G, Wu RE, Carlson DM. Induction in the expression of an unusual proline-rich protein by pig tracheal surface epithelial cells maintained in primary culture. Biochem Biophys Res Commun. 1990 Nov 15; 172(3):1304-9. PMID: 1700906.
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    121. Jee SH, Wu YC, Kuo YF, Chang SF, Chang CH, Wu R, Lu YC. Growth and characterization of normal human keratinocytes in F12 serum-free medium. J Formos Med Assoc. 1990 Jul; 89(7):559-64. PMID: 1701827.
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    122. Edmondson SW, Wu R, Mossman BT. Regulation of differentiation and keratin protein expression by vitamin A in primary cultures of hamster tracheal epithelial cells. J Cell Physiol. 1990 Jan; 142(1):21-30. PMID: 1688861.
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    123. Lin H, Carlson DM, St George JA, Plopper CG, Wu R. An ELISA method for the quantitation of tracheal mucins from human and nonhuman primates. Am J Respir Cell Mol Biol. 1989 Jul; 1(1):41-8. PMID: 2624758.
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    124. Huang TH, St George JA, Plopper CG, Wu R. Keratin protein expression during the development of conducting airway epithelium in nonhuman primates. Differentiation. 1989 Jul; 41(1):78-86. PMID: 2478409.
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    125. Whitcutt MJ, Adler KB, Wu R. A biphasic chamber system for maintaining polarity of differentiation of cultured respiratory tract epithelial cells. In Vitro Cell Dev Biol. 1988 May; 24(5):420-8. PMID: 3372447.
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    126. Ann DK, Wu MM, Huang T, Carlson DM, Wu R. Retinol-regulated gene expression in human tracheobronchial epithelial cells. Enhanced expression of elongation factor EF-1 alpha. J Biol Chem. 1988 Mar 15; 263(8):3546-9. PMID: 3346208.
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    127. Wu R, Sato GH, Whitcutt MJ. Developing differentiated epithelial cell cultures: airway epithelial cells. Fundam Appl Toxicol. 1986 May; 6(4):580-90. PMID: 3519341.
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    128. Wu R, Wu MM. Effects of retinoids on human bronchial epithelial cells: differential regulation of hyaluronate synthesis and keratin protein synthesis. J Cell Physiol. 1986 Apr; 127(1):73-82. PMID: 2420810.
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    129. Xu GL, Sivarajah K, Wu R, Nettesheim P, Eling T. Biosynthesis of prostaglandins by isolated and cultured airway epithelial cells. Exp Lung Res. 1986; 10(1):101-14. PMID: 3081334.
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    130. Wu R, Whitcutt MJ. Hormonal and environmental regulation of respiratory mucus cell differentiation. Prog Clin Biol Res. 1986; 226:319-32. PMID: 3543961.
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    131. Wu R, Nolan E, Turner C. Expression of tracheal differentiated functions in serum-free hormone-supplemented medium. J Cell Physiol. 1985 Nov; 125(2):167-81. PMID: 4055904.
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    132. Wu R, Yankaskas J, Cheng E, Knowles MR, Boucher R. Growth and differentiation of human nasal epithelial cells in culture. Serum-free, hormone-supplemented medium and proteoglycan synthesis. Am Rev Respir Dis. 1985 Aug; 132(2):311-20. PMID: 3896079.
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    133. Chang LY, Wu R, Nettesheim P. Morphological changes in rat tracheal cells during the adaptive and early growth phase in primary cell culture. J Cell Sci. 1985 Mar; 74:283-301. PMID: 4030910.
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    134. Nedrud JG, Wu R. In vitro mouse cytomegalovirus infection of mouse tracheal epithelial cells requires the presence of other cell types. J Gen Virol. 1984 Apr; 65 ( Pt 4):671-9. PMID: 6323617.
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    135. Lee TC, Wu R, Brody AR, Barrett JC, Nettesheim P. Growth and differentiation of hamster tracheal epithelial cells in culture. Exp Lung Res. 1984; 6(1):27-45. PMID: 6734541.
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    136. Wu R, Smith D. Continuous multiplication of rabbit tracheal epithelial cells in a defined, hormone-supplemented medium. In Vitro. 1982 Sep; 18(9):800-12. PMID: 6757109.
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    137. Wu R, Wolfe RA, Sato GH. Distinctive effects of hydrocortisone on the modulation of EGF binding and cell growth in HeLa cells grown in defined medium. J Cell Physiol. 1981 Jul; 108(1):83-90. PMID: 6267079.
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    138. Wolfe RA, Wu R, Sato GH. Epidermal growth factor-induced down-regulation of receptor does not occur in HeLa cells grown in defined medium. Proc Natl Acad Sci U S A. 1980 May; 77(5):2735-9. PMID: 6248863.
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    139. Bottenstein J, Hayashi I, Hutchings S, Masui H, Mather J, McClure DB, Ohasa S, Rizzino A, Sato G, Serrero G, Wolfe R, Wu R. The growth of cells in serum-free hormone-supplemented media. Methods Enzymol. 1979; 58:94-109. PMID: 423795.
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    140. Wu R, Sato GH. Replacement of serum in cell culture by hormones: a study of hormonal regulation of cell growth and specific gene expression. J Toxicol Environ Health. 1978 Mar-May; 4(2-3):427-48. PMID: 660666.
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    141. Wu R, Geiduschek EP. Distinctive protein requirements of replication-dependent and -uncoupled bacteriophage T4 late gene expression. J Virol. 1977 Nov; 24(2):436-43. PMID: 916023.
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    142. Wu R, Geiduschek EP. The role of replication proteins in the regulation of bacteriophage T4 transcription. II. Gene 45 and late transcription uncoupled from replication. J Mol Biol. 1975 Aug 25; 96(4):539-62. PMID: 1195366.
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    143. Wu R, Geiduschek EP. The role of replication proteins in the regulation of bacteriophage T4 transcription. I. Gene 45 and hydroxymethyl-C-containing DNA. J Mol Biol. 1975 Aug 25; 96(4):513-38. PMID: 1104860.
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    144. Wu R, Wu JL, Yeh YC. Role of gene 59 of bacteriophage T4 in repair of UV-irradiated and alkylated DNA in vivo. J Virol. 1975 Jul; 16(1):5-16. PMID: 166207.
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    145. Wu R, Yeh YC. DNA arrested mutants of gene 59 of bacteriophage T4. II. Replicative intermediates. Virology. 1974 May; 59(1):108-22. PMID: 4596837.
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    146. Wu R, Ma FJ, Yeh YC. Suppression of DNA-arrested synthesis in mutants defective in gene 59 of bacteriophage T4. Virology. 1972 Jan; 47(1):147-56. PMID: 4550789.
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