Michael S Denison

Title(s)Professor Emeritus, Environmental Toxicology
SchoolUniversity of California, Davis
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    1. Woodsmoke Extracts Cross-Link Proteins and Induce Cornified Envelope Formation without Stimulating Keratinocyte Terminal Differentiation. Toxicol Sci. 2021 Jun 04. Lin LW, Denison MS, Rice RH. PMID: 34086961.
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    2. Using Estrogenic Activity and Nontargeted Chemical Analysis to Identify Contaminants in Sewage Sludge. Environ Sci Technol. 2021 05 18; 55(10):6729-6739. Black GP, He G, Denison MS, Young TM. PMID: 33909413.
      View in: PubMed   Mentions:    Fields:    Translation:PHPublic Health
    3. Identifying Toxicologically Significant Compounds in Urban Wildfire Ash Using In Vitro Bioassays and High-Resolution Mass Spectrometry. Environ Sci Technol. 2021 03 16; 55(6):3657-3667. Young TM, Black GP, Wong L, Bloszies CS, Fiehn O, He G, Denison MS, Vogel CFA, Durbin-Johnson B. PMID: 33647203.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. Evaluation of the dioxin-like toxicity in soil samples from Thua Thien Hue province using the AhR-CALUX bioassay - An update of Agent Orange contamination in Vietnam. Ecotoxicol Environ Saf. 2021 Apr 01; 212:111971. My TTA, Dat ND, Van Langenhove K, Denison MS, Long HT, Elskens M. PMID: 33513480.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsPHPublic Health
    5. An aryl hydrocarbon receptor from the caecilian Gymnopis multiplicata suggests low dioxin affinity in the ancestor of all three amphibian orders. Gen Comp Endocrinol. 2020 12 01; 299:113592. Kazzaz SA, Giani Tagliabue S, Franks DG, Denison MS, Hahn ME, Bonati L, Powell WH. PMID: 32858041.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. The Cellular and Molecular Determinants of Naphthoquinone-Dependent Activation of the Aryl Hydrocarbon Receptor. Int J Mol Sci. 2020 Jun 09; 21(11). Faber SC, Giani Tagliabue S, Bonati L, Denison MS. PMID: 32526934.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. Development of a novel recombinant cell line for detection and characterization of Ah receptor nuclear translocation in intact cells. Toxicol In Vitro. 2020 Aug; 66:104873. Hayashi A, Denison MS. PMID: 32333947.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    8. Transitional States in Ligand-Dependent Transformation of the Aryl Hydrocarbon Receptor into Its DNA-Binding Form. Int J Mol Sci. 2020 Apr 02; 21(7). Soshilov AA, Motta S, Bonati L, Denison MS. PMID: 32252465.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    9. A Biomimetic, One-Step Transformation of Simple Indolic Compounds to Malassezia-Related Alkaloids with High AhR Potency and Efficacy. Chem Res Toxicol. 2019 11 18; 32(11):2238-2249. Mexia N, Koutrakis S, He G, Skaltsounis AL, Denison MS, Magiatis P. PMID: 31647221.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    10. Vemurafenib acts as an aryl hydrocarbon receptor antagonist: Implications for inflammatory cutaneous adverse events. Allergy. 2019 12; 74(12):2437-2448. Hawerkamp HC, Kislat A, Gerber PA, Pollet M, Rolfes KM, Soshilov AA, Denison MS, Momin AA, Arold ST, Datsi A, Braun SA, Oláh P, Lacouture ME, Krutmann J, Haarmann-Stemmann T, Homey B, Meller S. PMID: 31269229.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    11. Modeling the binding of diverse ligands within the Ah receptor ligand binding domain. Sci Rep. 2019 07 23; 9(1):10693. Giani Tagliabue S, Faber SC, Motta S, Denison MS, Bonati L. PMID: 31337850.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    12. Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma. Nat Commun. 2018 11 14; 9(1):4775. Corre S, Tardif N, Mouchet N, Leclair HM, Boussemart L, Gautron A, Bachelot L, Perrot A, Soshilov A, Rogiers A, Rambow F, Dumontet E, Tarte K, Bessede A, Guillemin GJ, Marine JC, Denison MS, Gilot D, Galibert MD. PMID: 30429474.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    13. Comparative In Vitro and In Silico Analysis of the Selectivity of Indirubin as a Human Ah Receptor Agonist. Int J Mol Sci. 2018 Sep 10; 19(9). Faber SC, Soshilov AA, Giani Tagliabue S, Bonati L, Denison MS. PMID: 30201897.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    14. Aryl hydrocarbon receptor is activated in patients and mice with chronic kidney disease. Kidney Int. 2018 04; 93(4):986-999. Dou L, Poitevin S, Sallée M, Addi T, Gondouin B, McKay N, Denison MS, Jourde-Chiche N, Duval-Sabatier A, Cerini C, Brunet P, Dignat-George F, Burtey S. PMID: 29395338.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    15. In Vitro Evaluation of Mitochondrial Function and Estrogen Signaling in Cell Lines Exposed to the Antiseptic Cetylpyridinium Chloride. Environ Health Perspect. 2017 08 22; 125(8):087015. Datta S, He G, Tomilov A, Sahdeo S, Denison MS, Cortopassi G. PMID: 28885978.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    16. Structural modeling of the AhR:ARNT complex in the bHLH-PASA-PASB region elucidates the key determinants of dimerization. Mol Biosyst. 2017 May 02; 13(5):981-990. Corrada D, Denison MS, Bonati L. PMID: 28393157.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    17. Use of nuclear receptor luciferase-based bioassays to detect endocrine active chemicals in a biosolids-biochar amended soil. Chemosphere. 2017 Aug; 181:160-167. Anderson CG, Joshi G, Bair DA, Oriol C, He G, Parikh SJ, Denison MS, Scow KM. PMID: 28437741.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsPHPublic Health
    18. Down-regulation of cytochrome P450 1A1 by monomethylarsonous acid in human HepG2 cells. Toxicol Lett. 2017 Mar 15; 270:34-50. Elshenawy OH, Abdelhamid G, Soshilov AA, Denison MS, El-Kadi AO. PMID: 28189647.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    19. And Now for Something Completely Different: Diversity in Ligand-Dependent Activation of Ah Receptor Responses. Curr Opin Toxicol. 2017 Feb; 2:124-131. Denison MS, Faber SC. PMID: 28845473.
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    20. Editor's Highlight: Microbial-Derived 1,4-Dihydroxy-2-naphthoic Acid and Related Compounds as Aryl Hydrocarbon Receptor Agonists/Antagonists: Structure-Activity Relationships and Receptor Modeling. Toxicol Sci. 2017 02; 155(2):458-473. Cheng Y, Jin UH, Davidson LA, Chapkin RS, Jayaraman A, Tamamis P, Orr A, Allred C, Denison MS, Soshilov A, Weaver E, Safe S. PMID: 27837168.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    21. Effect of benzene and ethylbenzene on the transcription of methyl-tert-butyl ether degradation genes of Methylibium petroleiphilum PM1. Microbiology (Reading). 2016 09; 162(9):1563-1571. Joshi G, Schmidt R, Scow KM, Denison MS, Hristova KR. PMID: 27450417.
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    22. Deciphering Dimerization Modes of PAS Domains: Computational and Experimental Analyses of the AhR:ARNT Complex Reveal New Insights Into the Mechanisms of AhR Transformation. PLoS Comput Biol. 2016 06; 12(6):e1004981. Corrada D, Soshilov AA, Denison MS, Bonati L. PMID: 27295348.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    23. Auto-induction mechanism of aryl hydrocarbon receptor 2 (AHR2) gene by TCDD-activated AHR1 and AHR2 in the red seabream (Pagrus major). Arch Toxicol. 2017 Jan; 91(1):301-312. Bak SM, Iida M, Soshilov AA, Denison MS, Iwata H, Kim EY. PMID: 27188387.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    24. Changes in Menidia beryllina Gene Expression and In Vitro Hormone-Receptor Activation After Exposure to Estuarine Waters Near Treated Wastewater Outfalls. Arch Environ Contam Toxicol. 2016 Aug; 71(2):210-23. Cole BJ, Brander SM, Jeffries KM, Hasenbein S, He G, Denison MS, Fangue NA, Connon RE. PMID: 27155869.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsPHPublic Health
    25. Development of a recombinant human ovarian (BG1) cell line containing estrogen receptor a and ß for improved detection of estrogenic/antiestrogenic chemicals. Environ Toxicol Chem. 2016 Jan; 35(1):91-100. Brennan JC, Bassal A, He G, Denison MS. PMID: 26139245.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    26. Effects of Neonicotinoids on Promoter-Specific Expression and Activity of Aromatase (CYP19) in Human Adrenocortical Carcinoma (H295R) and Primary Umbilical Vein Endothelial (HUVEC) Cells. Toxicol Sci. 2016 Jan; 149(1):134-44. Caron-Beaudoin É, Denison MS, Sanderson JT. PMID: 26464060.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    27. Development of Species-Specific Ah Receptor-Responsive Third Generation CALUX Cell Lines with Enhanced Responsiveness and Improved Detection Limits. Environ Sci Technol. 2015 Oct 06; 49(19):11903-12. Brennan JC, He G, Tsutsumi T, Zhao J, Wirth E, Fulton MH, Denison MS. PMID: 26366531.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    28. Naturally occurring marine brominated indoles are aryl hydrocarbon receptor ligands/agonists. Chem Res Toxicol. 2015 Jun 15; 28(6):1176-85. DeGroot DE, Franks DG, Higa T, Tanaka J, Hahn ME, Denison MS. PMID: 26001051.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    29. An Aryl Hydrocarbon Receptor from the Salamander Ambystoma mexicanum Exhibits Low Sensitivity to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Environ Sci Technol. 2015 Jun 02; 49(11):6993-7001. Shoots J, Fraccalvieri D, Franks DG, Denison MS, Hahn ME, Bonati L, Powell WH. PMID: 25941739.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    30. Gene mdpC plays a regulatory role in the methyl-tert-butyl ether degradation pathway of Methylibium petroleiphilum strain PM1. FEMS Microbiol Lett. 2015 Apr; 362(7). Joshi G, Schmidt R, Scow KM, Denison MS, Hristova KR. PMID: 25724531.
      View in: PubMed   Mentions: 1     Fields:    Translation:CellsPHPublic Health
    31. Pityriazepin and other potent AhR ligands isolated from Malassezia furfur yeast. Arch Biochem Biophys. 2015 Apr 01; 571:16-20. Mexia N, Gaitanis G, Velegraki A, Soshilov A, Denison MS, Magiatis P. PMID: 25721496.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    32. Metformin inhibits 7,12-dimethylbenz[a]anthracene-induced breast carcinogenesis and adduct formation in human breast cells by inhibiting the cytochrome P4501A1/aryl hydrocarbon receptor signaling pathway. Toxicol Appl Pharmacol. 2015 Apr 15; 284(2):217-26. Maayah ZH, Ghebeh H, Alhaider AA, El-Kadi AO, Soshilov AA, Denison MS, Ansari MA, Korashy HM. PMID: 25697376.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    33. Chemicals having estrogenic activity can be released from some bisphenol A-free, hard and clear, thermoplastic resins. Environ Health. 2014 Dec 04; 13:103. Bittner GD, Denison MS, Yang CZ, Stoner MA, He G. PMID: 25477047.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    34. Activation of the aryl hydrocarbon receptor by the widely used Src family kinase inhibitor 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d]pyrimidine (PP2). Arch Toxicol. 2015 Aug; 89(8):1329-36. Frauenstein K, Tigges J, Soshilov AA, Kado S, Raab N, Fritsche E, Haendeler J, Denison MS, Vogel CF, Haarmann-Stemmann T. PMID: 25082669.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    35. Aryl hydrocarbon receptor control of a disease tolerance defence pathway. Nature. 2014 Jul 10; 511(7508):184-90. Bessede A, Gargaro M, Pallotta MT, Matino D, Servillo G, Brunacci C, Bicciato S, Mazza EM, Macchiarulo A, Vacca C, Iannitti R, Tissi L, Volpi C, Belladonna ML, Orabona C, Bianchi R, Lanz TV, Platten M, Della Fazia MA, Piobbico D, Zelante T, Funakoshi H, Nakamura T, Gilot D, Denison MS, Guillemin GJ, DuHadaway JB, Prendergast GC, Metz R, Geffard M, Boon L, Pirro M, Iorio A, Veyret B, Romani L, Grohmann U, Fallarino F, Puccetti P. PMID: 24930766.
      View in: PubMed   Mentions: 244     Fields:    Translation:AnimalsCells
    36. Enantiospecific effects of ketoconazole on aryl hydrocarbon receptor. PLoS One. 2014; 9(7):e101832. Novotna A, Korhonova M, Bartonkova I, Soshilov AA, Denison MS, Bogdanova K, Kolar M, Bednar P, Dvorak Z. PMID: 25000292.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    37. In vitro and in silico derived relative effect potencies of ah-receptor-mediated effects by PCDD/Fs and PCBs in rat, mouse, and guinea pig CALUX cell lines. Chem Res Toxicol. 2014 Jul 21; 27(7):1120-32. Ghorbanzadeh M, van Ede KI, Larsson M, van Duursen MB, Poellinger L, Lücke-Johansson S, Machala M, Pencíková K, Vondrácek J, van den Berg M, Denison MS, Ringsted T, Andersson PL. PMID: 24901989.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    38. Ligand promiscuity of aryl hydrocarbon receptor agonists and antagonists revealed by site-directed mutagenesis. Mol Cell Biol. 2014 May; 34(9):1707-19. Soshilov AA, Denison MS. PMID: 24591650.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    39. Cross-talk between aryl hydrocarbon receptor and the inflammatory response: a role for nuclear factor-?B. J Biol Chem. 2014 Jan 17; 289(3):1866-75. Vogel CF, Khan EM, Leung PS, Gershwin ME, Chang WL, Wu D, Haarmann-Stemmann T, Hoffmann A, Denison MS. PMID: 24302727.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    40. Lack of ligand-selective binding of the aryl hydrocarbon receptor to putative DNA binding sites regulating expression of Bax and paraoxonase 1 genes. Arch Biochem Biophys. 2014 Jan 01; 541:13-20. DeGroot DE, Hayashi A, Denison MS. PMID: 24200861.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    41. Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanisms. Free Radic Biol Med. 2014 Feb; 67:171-87. Anwar-Mohamed A, Elshenawy OH, Soshilov AA, Denison MS, Chris Le X, Klotz LO, El-Kadi AO. PMID: 24161444.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    42. Nucleotide specificity of DNA binding of the aryl hydrocarbon receptor:ARNT complex is unaffected by ligand structure. Toxicol Sci. 2014 Jan; 137(1):102-13. DeGroot DE, Denison MS. PMID: 24136190.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    43. From 'omics to otoliths: responses of an estuarine fish to endocrine disrupting compounds across biological scales. PLoS One. 2013; 8(9):e74251. Brander SM, Connon RE, He G, Hobbs JA, Smalling KL, Teh SJ, White JW, Werner I, Denison MS, Cherr GN. PMID: 24086325.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    44. 2,3-cis-2R,3R-(-)-epiafzelechin-3-O-p-coumarate, a novel flavan-3-ol isolated from Fallopia convolvulus seed, is an estrogen receptor agonist in human cell lines. BMC Complement Altern Med. 2013 Jun 14; 13:133. Brennan JC, Denison MS, Holstege DM, Magiatis P, Dallas JL, Gutierrez EG, Soshilov AA, Millam JR. PMID: 23768005.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    45. Ginsenosides are novel naturally-occurring aryl hydrocarbon receptor ligands. PLoS One. 2013; 8(6):e66258. Hu Q, He G, Zhao J, Soshilov A, Denison MS, Zhang A, Yin H, Fraccalvieri D, Bonati L, Xie Q, Zhao B. PMID: 23776647.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    46. Effects of anthocyanins on the AhR-CYP1A1 signaling pathway in human hepatocytes and human cancer cell lines. Toxicol Lett. 2013 Jul 31; 221(1):1-8. Kamenickova A, Anzenbacherova E, Pavek P, Soshilov AA, Denison MS, Zapletalova M, Anzenbacher P, Dvorak Z. PMID: 23735880.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    47. Polybrominated dibenzo-p-dioxins, dibenzofurans, and biphenyls: inclusion in the toxicity equivalency factor concept for dioxin-like compounds. Toxicol Sci. 2013 Jun; 133(2):197-208. van den Berg M, Denison MS, Birnbaum LS, Devito MJ, Fiedler H, Falandysz J, Rose M, Schrenk D, Safe S, Tohyama C, Tritscher A, Tysklind M, Peterson RE. PMID: 23492812.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsPHPublic Health
    48. Malassezia yeasts produce a collection of exceptionally potent activators of the Ah (dioxin) receptor detected in diseased human skin. J Invest Dermatol. 2013 Aug; 133(8):2023-30. Magiatis P, Pappas P, Gaitanis G, Mexia N, Melliou E, Galanou M, Vlachos C, Stathopoulou K, Skaltsounis AL, Marselos M, Velegraki A, Denison MS, Bassukas ID. PMID: 23448877.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    49. Specific ligand binding domain residues confer low dioxin responsiveness to AHR1ß of Xenopus laevis. Biochemistry. 2013 Mar 12; 52(10):1746-54. Odio C, Holzman SA, Denison MS, Fraccalvieri D, Bonati L, Franks DG, Hahn ME, Powell WH. PMID: 23394719.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    50. Common commercial and consumer products contain activators of the aryl hydrocarbon (dioxin) receptor. PLoS One. 2013; 8(2):e56860. Zhao B, Bohonowych JE, Timme-Laragy A, Jung D, Affatato AA, Rice RH, Di Giulio RT, Denison MS. PMID: 23441220.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    51. Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174T. Toxicol Lett. 2013 Apr 26; 218(3):253-9. Kamenickova A, Anzenbacherova E, Pavek P, Soshilov AA, Denison MS, Anzenbacher P, Dvorak Z. PMID: 23419638.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    52. Comparative analysis of homology models of the AH receptor ligand binding domain: verification of structure-function predictions by site-directed mutagenesis of a nonfunctional receptor. Biochemistry. 2013 Jan 29; 52(4):714-25. Fraccalvieri D, Soshilov AA, Karchner SI, Franks DG, Pandini A, Bonati L, Hahn ME, Denison MS. PMID: 23286227.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    53. The in vivo estrogenic and in vitro anti-estrogenic activity of permethrin and bifenthrin. Environ Toxicol Chem. 2012 Dec; 31(12):2848-55. Brander SM, He G, Smalling KL, Denison MS, Cherr GN. PMID: 23007834.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    54. Novel 2-amino-isoflavones exhibit aryl hydrocarbon receptor agonist or antagonist activity in a species/cell-specific context. Toxicology. 2012 Jul 16; 297(1-3):26-33. Wall RJ, He G, Denison MS, Congiu C, Onnis V, Fernandes A, Bell DR, Rose M, Rowlands JC, Balboni G, Mellor IR. PMID: 22507882.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    55. A novel prenylflavone restricts breast cancer cell growth through AhR-mediated destabilization of ERa protein. Carcinogenesis. 2012 May; 33(5):1089-97. Tiong CT, Chen C, Zhang SJ, Li J, Soshilov A, Denison MS, Lee LS, Tam VH, Wong SP, Xu HE, Yong EL. PMID: 22345291.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    56. New aryl hydrocarbon receptor homology model targeted to improve docking reliability. J Chem Inf Model. 2011 Nov 28; 51(11):2868-81. Motto I, Bordogna A, Soshilov AA, Denison MS, Bonati L. PMID: 21981577.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    57. Harmaline and harmalol inhibit the carcinogen-activating enzyme CYP1A1 via transcriptional and posttranslational mechanisms. Food Chem Toxicol. 2012 Feb; 50(2):353-62. El Gendy MA, Soshilov AA, Denison MS, El-Kadi AO. PMID: 22037238.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    58. Transcriptional and posttranslational inhibition of dioxin-mediated induction of CYP1A1 by harmine and harmol. Toxicol Lett. 2012 Jan 05; 208(1):51-61. El Gendy MA, Soshilov AA, Denison MS, El-Kadi AO. PMID: 22001777.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    59. Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor. Toxicol Sci. 2011 Nov; 124(1):1-22. Denison MS, Soshilov AA, He G, DeGroot DE, Zhao B. PMID: 21908767.
      View in: PubMed   Mentions: 225     Fields:    Translation:HumansAnimalsCells
    60. Ligand displaces heat shock protein 90 from overlapping binding sites within the aryl hydrocarbon receptor ligand-binding domain. J Biol Chem. 2011 Oct 07; 286(40):35275-82. Soshilov A, Denison MS. PMID: 21856752.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    61. The p38 MAPK inhibitor SB203580 induces cytochrome P450 1A1 gene expression in murine and human hepatoma cell lines through ligand-dependent aryl hydrocarbon receptor activation. Chem Res Toxicol. 2011 Sep 19; 24(9):1540-8. Korashy HM, Anwar-Mohamed A, Soshilov AA, Denison MS, El-Kadi AO. PMID: 21732638.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    62. Third-generation Ah receptor-responsive luciferase reporter plasmids: amplification of dioxin-responsive elements dramatically increases CALUX bioassay sensitivity and responsiveness. Toxicol Sci. 2011 Oct; 123(2):511-22. He G, Tsutsumi T, Zhao B, Baston DS, Zhao J, Heath-Pagliuso S, Denison MS. PMID: 21775728.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    63. The CALUX bio-assay: analytical comparison between mouse hepatoma cell lines with a low (H1L6.1c3) and high (H1L7.5c1) number of dioxin response elements. Talanta. 2011 Sep 30; 85(4):2039-46. Van Langenhove K, Croes K, Denison MS, Elskens M, Baeyens W. PMID: 21872055.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    64. Identification of benzothiazole derivatives and polycyclic aromatic hydrocarbons as aryl hydrocarbon receptor agonists present in tire extracts. Environ Toxicol Chem. 2011 Aug; 30(8):1915-25. He G, Zhao B, Denison MS. PMID: 21590714.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    65. Comparative gene responses to collected ambient particles in vitro: endothelial responses. Physiol Genomics. 2011 Aug 16; 43(15):917-29. Aung HH, Lame MW, Gohil K, He G, Denison MS, Rutledge JC, Wilson DW. PMID: 21652769.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    66. Considerations for potency equivalent calculations in the Ah receptor-based CALUX bioassay: normalization of superinduction results for improved sample potency estimation. Talanta. 2011 Feb 15; 83(5):1415-21. Baston DS, Denison MS. PMID: 21238730.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    67. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced MUC5AC expression: aryl hydrocarbon receptor-independent/EGFR/ERK/p38-dependent SP1-based transcription. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):270-6. Lee YC, Oslund KL, Thai P, Velichko S, Fujisawa T, Duong T, Denison MS, Wu R. PMID: 20971882.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    68. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science. 2010 Sep 10; 329(5997):1345-8. Boitano AE, Wang J, Romeo R, Bouchez LC, Parker AE, Sutton SE, Walker JR, Flaveny CA, Perdew GH, Denison MS, Schultz PG, Cooke MP. PMID: 20688981.
      View in: PubMed   Mentions: 391     Fields:    Translation:HumansAnimalsCells
    69. CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor. Toxicol Sci. 2010 Oct; 117(2):393-403. Zhao B, Degroot DE, Hayashi A, He G, Denison MS. PMID: 20634293.
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    70. Enhancing the response of CALUX and CAFLUX cell bioassays for quantitative detection of dioxin-like compounds. Sci China Chem. 2010 May; 53(5):1010-1016. Zhao B, Baston DS, Khan E, Sorrentino C, Denison MS. PMID: 21394221.
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    71. Effect based monitoring of seasonal ambient air exposures in Australia sampled by PUF passive air samplers. Atmos Pollut Res. 2010 Jan 01; 1(1):50-58. Kennedy K, Macova M, Bartkow ME, Hawker DW, Zhao B, Denison MS, Mueller JF. PMID: 21552507.
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    72. Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key enzymes and receptors. Environ Health Perspect. 2009 Dec; 117(12):1867-72. Morisseau C, Merzlikin O, Lin A, He G, Feng W, Padilla I, Denison MS, Pessah IN, Hammock BD. PMID: 20049205.
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    73. Detection of the TCDD binding-fingerprint within the Ah receptor ligand binding domain by structurally driven mutagenesis and functional analysis. Biochemistry. 2009 Jun 30; 48(25):5972-83. Pandini A, Soshilov AA, Song Y, Zhao J, Bonati L, Denison MS. PMID: 19456125.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    74. Assessing indoor air exposures using passive sampling with bioanalytical methods for estrogenicity and aryl hydrocarbon receptor activity. Anal Bioanal Chem. 2009 Jul; 394(5):1413-21. Kennedy K, Macova M, Leusch F, Bartkow ME, Hawker DW, Zhao B, Denison MS, Mueller JF. PMID: 19430962.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCellsPHPublic Health
    75. Reduction of vitellogenin synthesis by an aryl hydrocarbon receptor agonist in the white sturgeon (Acipenser transmontamus). Environ Toxicol Chem. 2009 Aug; 28(8):1749-55. Palumbo AJ, Denison MS, Doroshov SI, Tjeerdema RS. PMID: 19292566.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    76. Dietary red clover (Trifolium pratense) induces oviduct growth and decreases ovary and testes growth in Japanese quail chicks. Reprod Toxicol. 2009 Jan; 27(1):63-71. Rochester JR, Klasing KC, Stevenson L, Denison MS, Berry W, Millam JR. PMID: 19103282.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    77. Mouse breast cancer model-dependent changes in metabolic syndrome-associated phenotypes caused by maternal dioxin exposure and dietary fat. Am J Physiol Endocrinol Metab. 2009 Jan; 296(1):E203-10. La Merrill M, Baston DS, Denison MS, Birnbaum LS, Pomp D, Threadgill DW. PMID: 18840765.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsPHPublic Health
    78. Role of the Per/Arnt/Sim domains in ligand-dependent transformation of the aryl hydrocarbon receptor. J Biol Chem. 2008 Nov 21; 283(47):32995-3005. Soshilov A, Denison MS. PMID: 18806268.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    79. In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: receptor-based bioassay screens. Environ Health Perspect. 2008 Sep; 116(9):1203-10. Ahn KC, Zhao B, Chen J, Cherednichenko G, Sanmarti E, Denison MS, Lasley B, Pessah IN, Kültz D, Chang DP, Gee SJ, Hammock BD. PMID: 18795164.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    80. Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound. Blood. 2008 Aug 15; 112(4):1158-65. Lawrence BP, Denison MS, Novak H, Vorderstrasse BA, Harrer N, Neruda W, Reichel C, Woisetschläger M. PMID: 18270326.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    81. Newspapers and newspaper ink contain agonists for the ah receptor. Toxicol Sci. 2008 Apr; 102(2):278-90. Bohonowych JE, Zhao B, Timme-Laragy A, Jung D, Di Giulio RT, Denison MS. PMID: 18203687.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    82. Persistent binding of ligands to the aryl hydrocarbon receptor. Toxicol Sci. 2007 Jul; 98(1):99-109. Bohonowych JE, Denison MS. PMID: 17431010.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    83. Induction of cyp1a1 is a nonspecific biomarker of aryl hydrocarbon receptor activation: results of large scale screening of pharmaceuticals and toxicants in vivo and in vitro. Mol Pharmacol. 2007 Jun; 71(6):1475-86. Hu W, Sorrentino C, Denison MS, Kolaja K, Fielden MR. PMID: 17327465.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimals
    84. Structural and functional characterization of the aryl hydrocarbon receptor ligand binding domain by homology modeling and mutational analysis. Biochemistry. 2007 Jan 23; 46(3):696-708. Pandini A, Denison MS, Song Y, Soshilov AA, Bonati L. PMID: 17223691.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    85. The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicol Sci. 2006 Oct; 93(2):223-41. Van den Berg M, Birnbaum LS, Denison M, De Vito M, Farland W, Feeley M, Fiedler H, Hakansson H, Hanberg A, Haws L, Rose M, Safe S, Schrenk D, Tohyama C, Tritscher A, Tuomisto J, Tysklind M, Walker N, Peterson RE. PMID: 16829543.
      View in: PubMed   Mentions: 469     Fields:    Translation:HumansAnimals
    86. Gas-phase ambient air contaminants exhibit significant dioxin-like and estrogen-like activity in vitro. Environ Health Perspect. 2006 May; 114(5):697-703. Klein GP, Hodge EM, Diamond ML, Yip A, Dann T, Stern G, Denison MS, Harper PA. PMID: 16675423.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    87. Interaction of diuron and related substituted phenylureas with the Ah receptor pathway. J Biochem Mol Toxicol. 2006; 20(3):103-13. Zhao B, Baston DS, Hammock B, Denison MS. PMID: 16788953.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    88. Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells. Toxicol Sci. 2004 Nov; 82(1):70-9. Sanderson JT, Hordijk J, Denison MS, Springsteel MF, Nantz MH, van den Berg M. PMID: 15319488.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    89. Recombinant cell bioassay systems for the detection and relative quantitation of halogenated dioxins and related chemicals. Talanta. 2004 Aug 08; 63(5):1123-33. Denison MS, Zhao B, Baston DS, Clark GC, Murata H, Han D. PMID: 18969542.
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    90. Analysis of Ah receptor pathway activation by brominated flame retardants. Chemosphere. 2004 Jun; 55(11):1509-18. Brown DJ, Van Overmeire I, Goeyens L, Denison MS, De Vito MJ, Clark GC. PMID: 15099731.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    91. Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins. Oncogene. 2004 May 27; 23(25):4400-12. Knockaert M, Blondel M, Bach S, Leost M, Elbi C, Hager GL, Nagy SR, Han D, Denison M, Ffrench M, Ryan XP, Magiatis P, Polychronopoulos P, Greengard P, Skaltsounis L, Meijer L. PMID: 15077192.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    92. Comparison of recombinant cell bioassays for the detection of Ah receptor agonists. Biofactors. 2004; 20(1):11-22. Han D, Nagy SR, Denison MS. PMID: 15096657.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    93. Reversible stepwise negative regulation of CYP1A1 in cultured rat epidermal cells. Arch Biochem Biophys. 2003 Nov 15; 419(2):158-69. Monk SA, Denison MS, Rice RH. PMID: 14592459.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    94. Activation of the Ah receptor by extracts of dietary herbal supplements, vegetables, and fruits. J Agric Food Chem. 2003 Aug 27; 51(18):5478-87. Jeuken A, Keser BJ, Khan E, Brouwer A, Koeman J, Denison MS. PMID: 12926901.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    95. Aryl hydrocarbon receptor-mediated activity of particulate organic matter from the Paso del Norte airshed along the U.S.-Mexico border. Environ Health Perspect. 2003 Aug; 111(10):1299-305. Arrieta DE, Ontiveros CC, Li WW, Garcia JH, Denison MS, McDonald JD, Burchiel SW, Washburn BS. PMID: 12896850.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    96. Synthesis and estrogen receptor affinity of a 4-hydroxytamoxifen-labeled ligand for diagnostic imaging. Bioorg Med Chem. 2002 Dec; 10(12):4075-82. Lashley MR, Niedzinski EJ, Rogers JM, Denison MS, Nantz MH. PMID: 12413861.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    97. Application of the luciferase cell culture bioassay for the detection of refined petroleum products. Mar Pollut Bull. 2002 Oct; 44(10):983-91. Ziccardi MH, Gardner IA, Mazet JA, Denison MS. PMID: 12474956.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    98. Application of the luciferase recombinant cell culture bioassay system for the analysis of polycyclic aromatic hydrocarbons. Environ Toxicol Chem. 2002 Oct; 21(10):2027-33. Ziccardi MH, Gardner IA, Denison MS. PMID: 12371477.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    99. Effects of estrogenic compounds on immunoglobulin production by mouse splenocytes. Biol Pharm Bull. 2002 Oct; 25(10):1263-7. Han D, Denison MS, Tachibana H, Yamada K. PMID: 12392075.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    100. Ligand binding and activation of the Ah receptor. Chem Biol Interact. 2002 Sep 20; 141(1-2):3-24. Denison MS, Pandini A, Nagy SR, Baldwin EP, Bonati L. PMID: 12213382.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    101. Specificity of nuclear protein binding to a CYP1A1 negative regulatory element. Biochem Biophys Res Commun. 2002 Aug 30; 296(4):799-805. Nagy SR, Denison MS. PMID: 12200118.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    102. The silencing mediator of retinoic acid and thyroid hormone receptors can interact with the aryl hydrocarbon (Ah) receptor but fails to repress Ah receptor-dependent gene expression. Arch Biochem Biophys. 2002 Jul 15; 403(2):189-201. Rushing SR, Denison MS. PMID: 12139968.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    103. Validation of a cell culture bioassay for detection of petroleum exposure in mink (Mustela vison) as a model for detection in sea otters (Enhydra lutris). Am J Vet Res. 2002 Jul; 63(7):963-8. Ziccardi MH, Mazet JA, Gardner IA, Boyce WM, Denison MS. PMID: 12118676.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCellsPHPublic Health
    104. Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids. Biosci Biotechnol Biochem. 2002 Jul; 66(7):1479-87. Han DH, Denison MS, Tachibana H, Yamada K. PMID: 12224631.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    105. Analysis of the antiestrogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in human ovarian carcinoma BG-1 cells. Mol Pharmacol. 2002 Jun; 61(6):1393-403. Rogers JM, Denison MS. PMID: 12021401.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    106. Analysis of the aryl hydrocarbon receptor (AhR) signal transduction pathway. Curr Protoc Toxicol. 2002 May; Chapter 4:Unit4.8. Denison MS, Rogers JM, Rushing SR, Jones CL, Tetangco SC, Heath-Pagliuso S. PMID: 20945300.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    107. Development of a green fluorescent protein-based cell bioassay for the rapid and inexpensive detection and characterization of ah receptor agonists. Toxicol Sci. 2002 Feb; 65(2):200-10. Nagy SR, Sanborn JR, Hammock BD, Denison MS. PMID: 11812924.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    108. Identification of novel Ah receptor agonists using a high-throughput green fluorescent protein-based recombinant cell bioassay. Biochemistry. 2002 Jan 22; 41(3):861-8. Nagy SR, Liu G, Lam KS, Denison MS. PMID: 11790108.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    109. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu Rev Pharmacol Toxicol. 2003; 43:309-34. Denison MS, Nagy SR. PMID: 12540743.
      View in: PubMed   Mentions: 478     Fields:    Translation:HumansAnimalsCells
    110. Correlation between the high expression of C/EBPbeta protein in F442A cells and their relative resistance to antiadipogenic action of TCDD in comparison to 3T3-L1 cells. J Biochem Mol Toxicol. 2002; 16(2):70-83. Liu PC, Moreno-Aliaga MJ, Dunlap DY, Hu XM, Denison MS, Matsumura F. PMID: 11979424.
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    111. Carbaryl, a carbamate insecticide, is a ligand for the hepatic Ah (dioxin) receptor. Toxicol Appl Pharmacol. 1998 Oct; 152(2):406-14. Denison MS, Phelan D, Winter GM, Ziccardi MH. PMID: 9853009.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
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