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Patrick S Leung, PhD

Title(s)Adjunct Professor, Rheumatology, Allergy, and Clinical Immunology
SchoolUniversity of California, Davis
Address6510 GBSF Bldg.
CA 95616
Phone530-754-4943
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    PLASMABLASTS, XENOBIOTICS AND LOSS OF TOLERANCE
    NIH/NIAID R21AI115120Dec 1, 2014 - Nov 30, 2016
    Role: Principal Investigator
    2006 Electronic presentation - split rate modules
    NIH/NIAID R21AI085022Jun 1, 2010 - May 31, 2013
    Role: Principal Investigator
    IG REPERTOIRE OF COMBINATORIAL AUTOANTIBODIES IN PBC
    NIH/NIAID R29AI031585Jul 1, 1993 - Jun 30, 1999
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Clinical Management of Primary Biliary Cholangitis-Strategies and Evolving Trends. Clin Rev Allergy Immunol. 2020 Oct; 59(2):175-194. Gao L, Wang L, Woo E, He X, Yang G, Bowlus C, Leung PSC, Gershwin ME. PMID: 31713023.
      View in: PubMed   Mentions: 2     Fields:    
    2. Glycomic analysis of antibody indicates distinctive glycosylation profile in patients with autoimmune cholangitis. J Autoimmun. 2020 Sep; 113:102503. Zhou X, Kailemia MJ, Sun Y, Shuai Z, Yang GX, Dhaliwal S, Cristoferi L, Leung PSC, Invernizzi P, Bowlus CL, Lebrilla CB, Ansari AA, Ridgway WM, Zhang W, Gershwin ME. PMID: 32546343.
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    3. Animal Models of Autoimmune Liver Diseases: a Comprehensive Review. Clin Rev Allergy Immunol. 2020 Apr; 58(2):252-271. Liu SP, Bian ZH, Zhao ZB, Wang J, Zhang W, Leung PSC, Li L, Lian ZX. PMID: 32076943.
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    4. Multi-omics: Differential expression of IFN-? results in distinctive mechanistic features linking chronic inflammation, gut dysbiosis, and autoimmune diseases. J Autoimmun. 2020 Jul; 111:102436. Bae HR, Leung PSC, Hodge DL, Fenimore JM, Jeon SM, Thovarai V, Dzutsev A, Welcher AA, Boedigheimer M, Damore MA, Choi MS, Fravell RA, Trinchieri G, Gershwin ME, Young HA. PMID: 32220507.
      View in: PubMed   Mentions: 1     Fields:    
    5. Overcoming Shellfish Allergy: How Far Have We Come? Int J Mol Sci. 2020 Mar 23; 21(6). Wai CYY, Leung NYH, Chu KH, Leung PSC, Leung ASY, Wong GWK, Leung TF. PMID: 32210187.
      View in: PubMed   Mentions:    Fields:    
    6. Extracellular vesicles microRNA analysis in type 1 autoimmune pancreatitis: Increased expression of microRNA-21. Pancreatology. 2020 Apr; 20(3):318-324. Nakamaru K, Tomiyama T, Kobayashi S, Ikemune M, Tsukuda S, Ito T, Tanaka T, Yamaguchi T, Ando Y, Ikeura T, Fukui T, Nishio A, Takaoka M, Uchida K, Leung PSC, Gershwin ME, Okazaki K. PMID: 32147308.
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    7. Cholangiocarcinoma in Patients with Primary Sclerosing Cholangitis (PSC): a Comprehensive Review. Clin Rev Allergy Immunol. 2020 Feb; 58(1):134-149. Song J, Li Y, Bowlus CL, Yang G, Leung PSC, Gershwin ME. PMID: 31463807.
      View in: PubMed   Mentions: 3     Fields:    
    8. Recurrence of disease following organ transplantation in autoimmune liver disease and systemic lupus erythematosus. Cell Immunol. 2020 01; 347:104021. Tanaka A, Kono H, Leung PSC, Gershwin ME. PMID: 31767117.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. The Pathogenesis of Primary Biliary Cholangitis: A Comprehensive Review. Semin Liver Dis. 2020 02; 40(1):34-48. Lleo A, Leung PSC, Hirschfield GM, Gershwin EM. PMID: 31537031.
      View in: PubMed   Mentions: 1     Fields:    
    10. Modulating Shrimp Tropomyosin-Mediated Allergy: Hypoallergen DNA Vaccines Induce Regulatory T Cells to Reduce Hypersensitivity in Mouse Model. Int J Mol Sci. 2019 Sep 19; 20(18). Wai CYY, Leung NYH, Leung PSC, Chu KH. PMID: 31546958.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    11. Mimotope-based allergen-specific immunotherapy: ready for prime time? Cell Mol Immunol. 2019 11; 16(11):890-891. Leung NYH, Wai CYY, Chu KH, Leung PSC. PMID: 31431690.
      View in: PubMed   Mentions:    Fields:    
    12. Regional Differences in Food Allergies. Clin Rev Allergy Immunol. 2019 Aug; 57(1):98-110. Tang R, Wang ZX, Ji CM, Leung PSC, Woo E, Chang C, Wang M, Liu B, Wei JF, Sun JL. PMID: 30612248.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    13. Principles of Allergen Immunotherapy and Its Clinical Application in China: Contrasts and Comparisons with the USA. Clin Rev Allergy Immunol. 2019 Aug; 57(1):128-143. Guan K, Liu B, Wang M, Li Z, Chang C, Cui L, Wang RQ, Wen LP, Leung PSC, Wei JF, Sun JL. PMID: 31243705.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsPHPublic Health
    14. Microbiota and Food Allergy. Clin Rev Allergy Immunol. 2019 Aug; 57(1):83-97. Shu SA, Yuen AWT, Woo E, Chu KH, Kwan HS, Yang GX, Yang Y, Leung PSC. PMID: 30564985.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    15. Immunotherapy of Food Allergy: a Comprehensive Review. Clin Rev Allergy Immunol. 2019 Aug; 57(1):55-73. Wai CYY, Leung NYH, Leung PSC, Chu KH. PMID: 28929421.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    16. DNGR1-mediated deletion of A20/Tnfaip3 in dendritic cells alters T and B-cell homeostasis and promotes autoimmune liver pathology. J Autoimmun. 2019 08; 102:167-178. Das T, Bergen IM, Koudstaal T, van Hulst JAC, van Loo G, Boonstra A, Vanwolleghem T, Leung PSC, Gershwin ME, Hendriks RW, Kool M. PMID: 31151831.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    17. The genetics of primary biliary cholangitis. Curr Opin Gastroenterol. 2019 03; 35(2):93-98. Tanaka A, Leung PSC, Gershwin ME. PMID: 30601157.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    18. Histologically proven AMA positive primary biliary cholangitis but normal serum alkaline phosphatase: Is alkaline phosphatase truly a surrogate marker? J Autoimmun. 2019 05; 99:33-38. Sun C, Xiao X, Yan L, Sheng L, Wang Q, Jiang P, Lian M, Li Y, Wei Y, Zhang J, Chen Y, Li B, Li Y, Huang B, Li Y, Peng Y, Chen X, Fang J, Qiu D, Hua J, Tang R, Leung P, Gershwin ME, Miao Q, Ma X. PMID: 30709684.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    19. Proteomics in Primary Biliary Cholangitis. Methods Mol Biol. 2019; 1981:163-173. Li Y, Tang R, Leung PSC, Gershwin ME, Ma X. PMID: 31016654.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    20. Common Variable Immunodeficiency and Liver Involvement. Clin Rev Allergy Immunol. 2018 Dec; 55(3):340-351. Song J, Lleo A, Yang GX, Zhang W, Bowlus CL, Gershwin ME, Leung PSC. PMID: 28785926.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    21. Anti-drug Antibodies Against a Novel Humanized Anti-CD20 Antibody Impair Its Therapeutic Effect on Primary Biliary Cholangitis in Human CD20- and Fc?R-Expressing Mice. Front Immunol. 2018; 9:2534. Moritoki Y, Tsuneyama K, Nakamura Y, Kikuchi K, Shiota A, Ohsugi Y, Lian ZX, Zhang W, Yang GX, Ueki S, Takeda M, Omokawa A, Saga T, Saga A, Watanabe D, Miura M, Ueno Y, Leung PSC, Tanaka A, Gershwin ME, Hirokawa M. PMID: 30450101.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    22. Etiopathogenesis of autoimmune hepatitis. J Autoimmun. 2018 12; 95:133-143. Floreani A, Restrepo-Jiménez P, Secchi MF, De Martin S, Leung PSC, Krawitt E, Bowlus CL, Gershwin ME, Anaya JM. PMID: 30385083.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    23. Molecular mimicry and autoimmunity. J Autoimmun. 2018 12; 95:100-123. Rojas M, Restrepo-Jiménez P, Monsalve DM, Pacheco Y, Acosta-Ampudia Y, Ramírez-Santana C, Leung PSC, Ansari AA, Gershwin ME, Anaya JM. PMID: 30509385.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    24. Long-term Outcomes of Autologous Peripheral Blood Stem Cell Transplantation in Patients With Cirrhosis. Clin Gastroenterol Hepatol. 2019 05; 17(6):1175-1182.e2. Guo C, Guo G, Zhou X, Chen Y, Han Z, Yang C, Zhao S, Su H, Lian Z, Leung PSC, Gershwin ME, Zhou X, Han Y. PMID: 30613001.
      View in: PubMed   Mentions:    Fields:    
    25. Diagnosis of fish and shellfish allergies. J Asthma Allergy. 2018; 11:247-260. Tong WS, Yuen AW, Wai CY, Leung NY, Chu KH, Leung PS. PMID: 30323632.
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    26. Endogenous IL-10 maintains immune tolerance but IL-10 gene transfer exacerbates autoimmune cholangitis. J Autoimmun. 2018 12; 95:159-170. Hsueh YH, Chen HW, Syu BJ, Lin CI, Leung PSC, Gershwin ME, Chuang YH. PMID: 30274824.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    27. Pathogen infections and primary biliary cholangitis. Clin Exp Immunol. 2019 01; 195(1):25-34. Tanaka A, Leung PSC, Gershwin ME. PMID: 30099750.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    28. The Critical Role of Chemokine (C-C Motif) Receptor 2-Positive Monocytes in Autoimmune Cholangitis. Front Immunol. 2018; 9:1852. Reuveni D, Gore Y, Leung PSC, Lichter Y, Moshkovits I, Kaminitz A, Brazowski E, Lefebvre E, Vig P, Varol C, Halpern Z, Shibolet O, Gershwin ME, Zigmond E. PMID: 30158929.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    29. The Genetics and Epigenetics of Primary Biliary Cholangitis. Clin Liver Dis. 2018 08; 22(3):443-455. Tanaka A, Leung PSC, Gershwin ME. PMID: 30259846.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    30. Evolution of our understanding of PBC. Best Pract Res Clin Gastroenterol. 2018 Jun - Aug; 34-35:3-9. Tanaka A, Leung PSC, Gershwin ME. PMID: 30343708.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    31. Junctional adhesion molecules JAM-B and JAM-C promote autoimmune-mediated liver fibrosis in mice. J Autoimmun. 2018 07; 91:83-96. Hintermann E, Bayer M, Conti CB, Fuchs S, Fausther M, Leung PS, Aurrand-Lions M, Taubert R, Pfeilschifter JM, Friedrich-Rust M, Schuppan D, Dranoff JA, Gershwin ME, Manns MP, Imhof BA, Christen U. PMID: 29753567.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    32. Characterization of Blimp-1 function in effector regulatory T cells. J Autoimmun. 2018 07; 91:73-82. Cretney E, Leung PS, Trezise S, Newman DM, Rankin LC, Teh CE, Putoczki TL, Gray DH, Belz GT, Mielke LA, Dias S, Nutt SL. PMID: 29724515.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    33. The Clinical Significance of GP73 in Immunologically Mediated Chronic Liver Diseases: Experimental Data and Literature Review. Clin Rev Allergy Immunol. 2018 Apr; 54(2):282-294. Yao M, Wang L, Leung PSC, Li Y, Liu S, Wang L, Guo X, Zhou G, Yan Y, Guan G, Chen X, Bowlus CL, Liu T, Jia J, Gershwin ME, Ma X, Zhao J, Lu F. PMID: 29256057.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    34. The immunobiology of mucosal-associated invariant T cell (MAIT) function in primary biliary cholangitis: Regulation by cholic acid-induced Interleukin-7. J Autoimmun. 2018 06; 90:64-75. Jiang X, Lian M, Li Y, Zhang W, Wang Q, Wei Y, Zhang J, Chen W, Xiao X, Miao Q, Bian Z, Qiu D, Fang J, Ansari AA, Leung PSC, Coppel RL, Tang R, Gershwin ME, Ma X. PMID: 29429758.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    35. The interplay of type I and type II interferons in murine autoimmune cholangitis as a basis for sex-biased autoimmunity. Hepatology. 2018 04; 67(4):1408-1419. Bae HR, Hodge DL, Yang GX, Leung PSC, Chodisetti SB, Valencia JC, Sanford M, Fenimore JM, Rahman ZSM, Tsuneyama K, Norman GL, Gershwin ME, Young HA. PMID: 28921595.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    36. Proteomic analysis reveals distinctive protein profiles involved in CD8+ T cell-mediated murine autoimmune cholangitis. Cell Mol Immunol. 2018 08; 15(8):756-767. Zhang W, Zhang R, Zhang J, Sun Y, Leung PS, Yang GX, Shuai Z, Ridgway WM, Gershwin ME. PMID: 29375127.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    37. Environmental basis of primary biliary cholangitis. Exp Biol Med (Maywood). 2018 01; 243(2):184-189. Tanaka A, Leung PS, Gershwin ME. PMID: 29307284.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    38. The molecular basis of immune regulation in autoimmunity. Clin Sci (Lond). 2018 01 16; 132(1):43-67. Yang SH, Gao CY, Li L, Chang C, Leung PSC, Gershwin ME, Lian ZX. PMID: 29305419.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    39. The immunobiology and clinical features of type 1 autoimmune polyglandular syndrome (APS-1). Autoimmun Rev. 2018 Jan; 17(1):78-85. Guo CJ, Leung PSC, Zhang W, Ma X, Gershwin ME. PMID: 29108822.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    40. Low-Dose Allergen-Specific Immunotherapy Induces Tolerance in a Murine Model of Shrimp Allergy. Int Arch Allergy Immunol. 2017; 174(2):86-96. Leung NYH, Wai CYY, Shu SA, Chang CC, Chu KH, Leung PSC. PMID: 29065408.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    41. Therapeutic and immunological interventions in primary biliary cholangitis: from mouse models to humans. Arch Med Sci. 2018 Jun; 14(4):930-940. Tanaka A, Leung PSC, Young HA, Gershwin ME. PMID: 30002712.
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    42. How the biliary tree maintains immune tolerance? Biochim Biophys Acta Mol Basis Dis. 2018 04; 1864(4 Pt B):1367-1373. Zhang H, Leung PSC, Gershwin ME, Ma X. PMID: 28844953.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    43. Autoreactive monoclonal antibodies from patients with primary biliary cholangitis recognize environmental xenobiotics. Hepatology. 2017 09; 66(3):885-895. Tanaka T, Zhang W, Sun Y, Shuai Z, Chida AS, Kenny TP, Yang GX, Sanz I, Ansari A, Bowlus CL, Ippolito GC, Coppel RL, Okazaki K, He XS, Leung PSC, Gershwin ME. PMID: 28470667.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    44. Bile acids and intestinal microbiota in autoimmune cholestatic liver diseases. Autoimmun Rev. 2017 Sep; 16(9):885-896. Li Y, Tang R, Leung PSC, Gershwin ME, Ma X. PMID: 28698093.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    45. Toward solving the etiological mystery of primary biliary cholangitis. Hepatol Commun. 2017 Jun; 1(4):275-287. Tanakaa A, Leung PS, Young HA, Gershwin ME. PMID: 29057387.
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    46. Trichloroethylene Exposure Reduces Liver Injury in a Mouse Model of Primary Biliary Cholangitis. Toxicol Sci. 2017 04 01; 156(2):428-437. Ray JL, Kopec AK, Joshi N, Cline-Fedewa H, Lash LH, Williams KJ, Leung PS, Gershwin ME, Luyendyk JP. PMID: 28115651.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    47. The fingerprint of antimitochondrial antibodies and the etiology of primary biliary cholangitis. Hepatology. 2017 05; 65(5):1670-1682. Shuai Z, Wang J, Badamagunta M, Choi J, Yang G, Zhang W, Kenny TP, Guggenheim K, Kurth MJ, Ansari AA, Voss J, Coppel RL, Invernizzi P, Leung PSC, Gershwin ME. PMID: 28100006.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    48. Chronic expression of interferon-gamma leads to murine autoimmune cholangitis with a female predominance. Hepatology. 2016 10; 64(4):1189-201. Bae HR, Leung PS, Tsuneyama K, Valencia JC, Hodge DL, Kim S, Back T, Karwan M, Merchant AS, Baba N, Feng D, Park O, Gao B, Yang GX, Gershwin ME, Young HA. PMID: 27178326.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    49. Endogenous interleukin-22 protects against inflammatory bowel disease but not autoimmune cholangitis in dominant negative form of transforming growth factor beta receptor type II mice. Clin Exp Immunol. 2016 08; 185(2):154-64. Yang GX, Sun Y, Tsuneyama K, Zhang W, Leung PS, He XS, Ansari AA, Bowlus C, Ridgway WM, Gershwin ME. PMID: 27148790.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    50. Environmental Basis of Autoimmunity. Clin Rev Allergy Immunol. 2016 Jun; 50(3):287-300. Floreani A, Leung PS, Gershwin ME. PMID: 25998909.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    51. A contemporary perspective on the molecular characteristics of mitochondrial autoantigens and diagnosis in primary biliary cholangitis. Expert Rev Mol Diagn. 2016 06; 16(6):697-705. Leung PS, Choi J, Yang G, Woo E, Kenny TP, Gershwin ME. PMID: 26953925.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    52. Autotaxin, Pruritus and Primary Biliary Cholangitis (PBC). Autoimmun Rev. 2016 Aug; 15(8):795-800. Sun Y, Zhang W, Evans JF, Floreani A, Zou Z, Nishio Y, Qi R, Leung PS, Bowlus CL, Gershwin ME. PMID: 27019050.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    53. Deletion of Galectin-3 Enhances Xenobiotic Induced Murine Primary Biliary Cholangitis by Facilitating Apoptosis of BECs and Release of Autoantigens. Sci Rep. 2016 Mar 21; 6:23348. Arsenijevic A, Milovanovic M, Milovanovic J, Stojanovic B, Zdravkovic N, Leung PS, Liu FT, Gershwin ME, Lukic ML. PMID: 26996208.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    54. Adaptive immunity in the liver. Cell Mol Immunol. 2016 05; 13(3):354-68. Shuai Z, Leung MW, He X, Zhang W, Yang G, Leung PS, Eric Gershwin M. PMID: 26996069.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    55. T cell epitope immunotherapy ameliorates allergic responses in a murine model of shrimp allergy. Clin Exp Allergy. 2016 Mar; 46(3):491-503. Wai CY, Leung NY, Leung PS, Chu KH. PMID: 26610061.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    56. Chemokine and chemokine receptors in autoimmunity: the case of primary biliary cholangitis. Expert Rev Clin Immunol. 2016 Jun; 12(6):661-72. Choi J, Selmi C, Leung PS, Kenny TP, Roskams T, Gershwin ME. PMID: 26821815.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    57. Transgenic Overexpression of Aryl Hydrocarbon Receptor Repressor (AhRR) and AhR-Mediated Induction of CYP1A1, Cytokines, and Acute Toxicity. Environ Health Perspect. 2016 07; 124(7):1071-83. Vogel CF, Chang WL, Kado S, McCulloh K, Vogel H, Wu D, Haarmann-Stemmann T, Yang G, Leung PS, Matsumura F, Gershwin ME. PMID: 26862745.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    58. Xenobiotics and loss of tolerance in primary biliary cholangitis. World J Gastroenterol. 2016 Jan 07; 22(1):338-48. Wang J, Yang G, Dubrovsky AM, Choi J, Leung PS. PMID: 26755880.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    59. IL-35 and Autoimmunity: a Comprehensive Perspective. Clin Rev Allergy Immunol. 2015 Dec; 49(3):327-32. Choi J, Leung PS, Bowlus C, Gershwin ME. PMID: 25619872.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    60. The Significance of Autoantibody Changes Over Time in Primary Biliary Cirrhosis. Am J Clin Pathol. 2015 Oct; 144(4):601-6. Tana MM, Shums Z, Milo J, Norman GL, Leung PS, Gershwin ME, Noureddin M, Kleiner DE, Zhao X, Heller T, Hoofnagle JH. PMID: 26386081.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    61. Gene Therapy for Autoimmune Disease. Clin Rev Allergy Immunol. 2015 Oct; 49(2):163-76. Shu SA, Wang J, Tao MH, Leung PS. PMID: 25277817.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    62. The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis. Cell Mol Immunol. 2017 Mar; 14(3):276-284. Tomiyama T, Yang GX, Zhao M, Zhang W, Tanaka H, Wang J, Leung PS, Okazaki K, He XS, Lu Q, Coppel RL, Bowlus CL, Gershwin ME. PMID: 26388238.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    63. Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one-compound peptide libraries. Cell Mol Immunol. 2017 Mar; 14(3):308-318. Leung NY, Wai CY, Ho MH, Liu R, Lam KS, Wang JJ, Shu SA, Chu KH, Leung PS. PMID: 26364917.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    64. Gastrointestinal Immune Response to the Shrimp Allergen Tropomyosin: Histological and Immunological Analysis in an Animal Model of Shrimp Tropomyosin Hypersensitivity. Int Arch Allergy Immunol. 2015; 167(1):29-40. Lam YF, Tong KK, Kwan KM, Tsuneyama K, Shu SA, Leung PS, Chu KH. PMID: 26112225.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    65. Animal models of primary biliary cirrhosis. Clin Rev Allergy Immunol. 2015 Jun; 48(2-3):142-53. Katsumi T, Tomita K, Leung PS, Yang GX, Gershwin ME, Ueno Y. PMID: 25771770.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    66. Immunological potential of cytotoxic T lymphocyte antigen 4 immunoglobulin in murine autoimmune cholangitis. Clin Exp Immunol. 2015 Jun; 180(3):371-82. Tanaka H, Yang GX, Tomiyama T, Tsuneyama K, Zhang W, Leung PS, Coppel RL, Joh T, Nadler SG, Ansari AA, Bowlus C, Gershwin ME. PMID: 25581259.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    67. Extrahepatic malignancies in primary biliary cirrhosis: a comparative study at two European centers. Clin Rev Allergy Immunol. 2015 Jun; 48(2-3):254-62. Floreani A, Spinazzè A, Caballeria L, Reig A, Cazzagon N, Franceschet I, Buja A, Furlan P, Harada K, Leung PS, Gershwin ME, Pares A. PMID: 25205363.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    68. Innate immunity drives the initiation of a murine model of primary biliary cirrhosis. PLoS One. 2015; 10(3):e0121320. Chang CH, Chen YC, Zhang W, Leung PS, Gershwin ME, Chuang YH. PMID: 25807531.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    69. Immunization with Hypoallergens of shrimp allergen tropomyosin inhibits shrimp tropomyosin specific IgE reactivity. PLoS One. 2014; 9(11):e111649. Wai CY, Leung NY, Ho MH, Gershwin LJ, Shu SA, Leung PS, Chu KH. PMID: 25365343.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    70. Successful immunotherapy of autoimmune cholangitis by adoptive transfer of forkhead box protein 3(+) regulatory T cells. Clin Exp Immunol. 2014 Nov; 178(2):253-61. Tanaka H, Zhang W, Yang GX, Ando Y, Tomiyama T, Tsuneyama K, Leung P, Coppel RL, Ansari AA, Lian ZX, Ridgway WM, Joh T, Gershwin ME. PMID: 25041369.
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    71. The autoimmune basis of alopecia areata: a comprehensive review. Autoimmun Rev. 2015 Feb; 14(2):81-9. Islam N, Leung PS, Huntley AC, Gershwin ME. PMID: 25315746.
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    72. Anti-kelch-like 12 and anti-hexokinase 1: novel autoantibodies in primary biliary cirrhosis. Liver Int. 2015 Feb; 35(2):642-51. Norman GL, Yang CY, Ostendorff HP, Shums Z, Lim MJ, Wang J, Awad A, Hirschfield GM, Milkiewicz P, Bloch DB, Rothschild KJ, Bowlus CL, Adamopoulos IE, Leung PS, Janssen HJ, Cheung AC, Coltescu C, Gershwin ME. PMID: 25243383.
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    73. Stem cell therapy in autoimmune rheumatic diseases: a comprehensive review. Clin Rev Allergy Immunol. 2014 Oct; 47(2):244-57. Liu B, Shu S, Kenny TP, Chang C, Leung PS. PMID: 25146442.
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    74. Ongoing activation of autoantigen-specific B cells in primary biliary cirrhosis. Hepatology. 2014 Nov; 60(5):1708-16. Zhang J, Zhang W, Leung PS, Bowlus CL, Dhaliwal S, Coppel RL, Ansari AA, Yang GX, Wang J, Kenny TP, He XS, Mackay IR, Gershwin ME. PMID: 25043065.
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    75. Innate immunity drives xenobiotic-induced murine autoimmune cholangitis. Clin Exp Immunol. 2014 Aug; 177(2):373-80. Chang CH, Chen YC, Yu YH, Tao MH, Leung PS, Ansari AA, Gershwin ME, Chuang YH. PMID: 24547942.
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    76. Shotgun proteomics: identification of unique protein profiles of apoptotic bodies from biliary epithelial cells. Hepatology. 2014 Oct; 60(4):1314-23. Lleo A, Zhang W, McDonald WH, Seeley EH, Leung PS, Coppel RL, Ansari AA, Adams DH, Afford S, Invernizzi P, Gershwin ME. PMID: 24841946.
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    77. Animal models of primary biliary cirrhosis. Semin Liver Dis. 2014 Aug; 34(3):285-96. Wang J, Yang GX, Tsuneyama K, Gershwin ME, Ridgway WM, Leung PS. PMID: 25057952.
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    78. The changing geoepidemiology of food allergies. Clin Rev Allergy Immunol. 2014 Jun; 46(3):169-79. Leung PS, Shu SA, Chang C. PMID: 24535418.
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    79. Current immunological and molecular biological perspectives on seafood allergy: a comprehensive review. Clin Rev Allergy Immunol. 2014 Jun; 46(3):180-97. Leung NY, Wai CY, Shu S, Wang J, Kenny TP, Chu KH, Leung PS. PMID: 23242979.
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    80. Common methodologies in the evaluation of food allergy: pitfalls and prospects of food allergy prevalence studies. Clin Rev Allergy Immunol. 2014 Jun; 46(3):198-210. Shu SA, Chang C, Leung PS. PMID: 23179516.
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    81. IL-12/Th1 and IL-23/Th17 biliary microenvironment in primary biliary cirrhosis: implications for therapy. Hepatology. 2014 May; 59(5):1944-53. Yang CY, Ma X, Tsuneyama K, Huang S, Takahashi T, Chalasani NP, Bowlus CL, Yang GX, Leung PS, Ansari AA, Wu L, Coppel RL, Gershwin ME. PMID: 24375552.
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    82. Combined anti-CD40 and anti-IL-23 monoclonal antibody therapy effectively suppresses tumor growth and metastases. Cancer Res. 2014 May 01; 74(9):2412-21. von Scheidt B, Leung PS, Yong MC, Zhang Y, Towne JE, Smyth MJ, Teng MW. PMID: 24556719.
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    83. Murine autoimmune cholangitis requires two hits: cytotoxic KLRG1(+) CD8 effector cells and defective T regulatory cells. J Autoimmun. 2014 May; 50:123-34. Huang W, Kachapati K, Adams D, Wu Y, Leung PS, Yang GX, Zhang W, Ansari AA, Flavell RA, Gershwin ME, Ridgway WM. PMID: 24556277.
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    84. Escherichia coli infection induces autoimmune cholangitis and anti-mitochondrial antibodies in non-obese diabetic (NOD).B6 (Idd10/Idd18) mice. Clin Exp Immunol. 2014 Feb; 175(2):192-201. Wang JJ, Yang GX, Zhang WC, Lu L, Tsuneyama K, Kronenberg M, Véla JL, Lopez-Hoyos M, He XS, Ridgway WM, Leung PS, Gershwin ME. PMID: 24128311.
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    85. Cross-talk between aryl hydrocarbon receptor and the inflammatory response: a role for nuclear factor-?B. J Biol Chem. 2014 Jan 17; 289(3):1866-75. Vogel CF, Khan EM, Leung PS, Gershwin ME, Chang WL, Wu D, Haarmann-Stemmann T, Hoffmann A, Denison MS. PMID: 24302727.
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    86. Anti-CD40 ligand monoclonal antibody delays the progression of murine autoimmune cholangitis. Clin Exp Immunol. 2013 Dec; 174(3):364-71. Tanaka H, Yang GX, Iwakoshi N, Knechtle SJ, Kawata K, Tsuneyama K, Leung P, Coppel RL, Ansari AA, Joh T, Bowlus C, Gershwin ME. PMID: 23981074.
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    87. The implication of vitamin D and autoimmunity: a comprehensive review. Clin Rev Allergy Immunol. 2013 Oct; 45(2):217-26. Yang CY, Leung PS, Adamopoulos IE, Gershwin ME. PMID: 23359064.
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    88. Identification of potential cytokine pathways for therapeutic intervention in murine primary biliary cirrhosis. PLoS One. 2013; 8(9):e74225. Kawata K, Tsuda M, Yang GX, Zhang W, Tanaka H, Tsuneyama K, Leung P, He XS, Knechtle S, Ansari AA, Coppel RL, Gershwin ME. PMID: 24040208.
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    89. Antimitochondrial antibody recognition and structural integrity of the inner lipoyl domain of the E2 subunit of pyruvate dehydrogenase complex. J Immunol. 2013 Sep 01; 191(5):2126-33. Wang J, Budamagunta MS, Voss JC, Kurth MJ, Lam KS, Lu L, Kenny TP, Bowlus C, Kikuchi K, Coppel RL, Ansari AA, Gershwin ME, Leung PS. PMID: 23894195.
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    90. Clonality, activated antigen-specific CD8(+) T cells, and development of autoimmune cholangitis in dnTGFßRII mice. Hepatology. 2013 Sep; 58(3):1094-104. Kawata K, Yang GX, Ando Y, Tanaka H, Zhang W, Kobayashi Y, Tsuneyama K, Leung PS, Lian ZX, Ridgway WM, Ansari AA, He XS, Gershwin ME. PMID: 23532950.
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    91. Reply: To PMID 22996325. Hepatology. 2013 Aug; 58(2):830. Gershwin ME, Leung PS, Ridgway WM, Coppel RL, Ansari AA. PMID: 23315750.
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    92. Human intrahepatic biliary epithelial cells engulf blebs from their apoptotic peers. Clin Exp Immunol. 2013 Apr; 172(1):95-103. Rong GH, Yang GX, Ando Y, Zhang W, He XS, Leung PS, Coppel RL, Ansari AA, Zhong R, Gershwin ME. PMID: 23480189.
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    93. Overexpression of microRNA-21 is associated with elevated pro-inflammatory cytokines in dominant-negative TGF-ß receptor type II mouse. J Autoimmun. 2013 Mar; 41:111-9. Ando Y, Yang GX, Kenny TP, Kawata K, Zhang W, Huang W, Leung PS, Lian ZX, Okazaki K, Ansari AA, He XS, Invernizzi P, Ridgway WM, Lu Q, Gershwin ME. PMID: 23395552.
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    94. Therapeutic effect of cytotoxic T lymphocyte antigen 4/immunoglobulin on a murine model of primary biliary cirrhosis. Hepatology. 2013 Feb; 57(2):708-15. Dhirapong A, Yang GX, Nadler S, Zhang W, Tsuneyama K, Leung P, Knechtle S, Ansari AA, Coppel RL, Liu FT, He XS, Gershwin ME. PMID: 22996325.
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    95. Deletion of interleukin (IL)-12p35 induces liver fibrosis in dominant-negative TGFß receptor type II mice. Hepatology. 2013 Feb; 57(2):806-16. Tsuda M, Zhang W, Yang GX, Tsuneyama K, Ando Y, Kawata K, Park O, Leung PS, Coppel RL, Ansari AA, Ridgway WM, Gao B, Lian ZX, Flavell R, He XS, Gershwin ME. PMID: 22576253.
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    96. Antimitochondrial antibody heterogeneity and the xenobiotic etiology of primary biliary cirrhosis. Hepatology. 2013 Apr; 57(4):1498-508. Chen RC, Naiyanetr P, Shu SA, Wang J, Yang GX, Kenny TP, Guggenheim KC, Butler JD, Bowlus C, Tao MH, Kurth MJ, Ansari AA, Kaplan M, Coppel RL, Lleo A, Gershwin ME, Leung PS. PMID: 23184636.
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    97. Environment and primary biliary cirrhosis: electrophilic drugs and the induction of AMA. J Autoimmun. 2013 Mar; 41:79-86. Leung PS, Wang J, Naiyanetr P, Kenny TP, Lam KS, Kurth MJ, Gershwin ME. PMID: 23352659.
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    98. Immunological orchestration of liver fibrosis. Clin Rev Allergy Immunol. 2012 Dec; 43(3):220-9. Tanaka H, Leung PS, Kenny TP, Gershwin ME, Bowlus CL. PMID: 22695942.
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    99. Lymphoma-like T cell infiltration in liver is associated with increased copy number of dominant negative form of TGFß receptor II. PLoS One. 2012; 7(11):e49413. Zhang W, Tsuda M, Yang GX, Tsuneyama K, He XS, Ansari AA, Ridgway WM, Coppel RL, Lian ZX, Leung PS, Gershwin ME. PMID: 23145171.
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    100. The immunobiology of colitis and cholangitis in interleukin-23p19 and interleukin-17A deleted dominant negative form of transforming growth factor beta receptor type II mice. Hepatology. 2012 Oct; 56(4):1418-26. Ando Y, Yang GX, Tsuda M, Kawata K, Zhang W, Nakajima T, Tsuneyama K, Leung P, Lian ZX, Okazaki K, Ridgway WM, Norman GL, Ansari AA, He XS, Coppel RL, Gershwin ME. PMID: 22532156.
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    101. Xenobiotics and autoimmunity: does acetaminophen cause primary biliary cirrhosis? Trends Mol Med. 2012 Oct; 18(10):577-82. Leung PS, Lam K, Kurth MJ, Coppel RL, Gershwin ME. PMID: 22920894.
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    102. Criteria for environmentally associated autoimmune diseases. J Autoimmun. 2012 Dec; 39(4):253-8. Miller FW, Pollard KM, Parks CG, Germolec DR, Leung PS, Selmi C, Humble MC, Rose NR. PMID: 22771005.
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    103. Mechanisms of environmental influence on human autoimmunity: a National Institute of Environmental Health Sciences expert panel workshop. J Autoimmun. 2012 Dec; 39(4):272-84. Selmi C, Leung PS, Sherr DH, Diaz M, Nyland JF, Monestier M, Rose NR, Gershwin ME. PMID: 22749494.
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    104. Mincle and human B cell function. J Autoimmun. 2012 12; 39(4):315-22. Kawata K, Illarionov P, Yang GX, Kenny TP, Zhang W, Tsuda M, Ando Y, Leung PS, Ansari AA, Gershwin ME. PMID: 22698596.
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    105. The role of natural killer (NK) and NK T cells in the loss of tolerance in murine primary biliary cirrhosis. Clin Exp Immunol. 2012 Jun; 168(3):279-84. Shimoda S, Tsuneyama K, Kikuchi K, Harada K, Nakanuma Y, Nakamura M, Ishibashi H, Hisamoto S, Niiro H, Leung PS, Ansari AA, Gershwin ME, Akashi K. PMID: 22519590.
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    106. Epitope-specific anti-nuclear antibodies are expressed in a mouse model of primary biliary cirrhosis and are cytokine-dependent. Clin Exp Immunol. 2012 Jun; 168(3):261-7. Yang CY, Leung PS, Yang GX, Kenny TP, Zhang W, Coppel R, Norman GL, Ansari AA, Mackay IR, Worman HJ, Gershwin ME. PMID: 22519587.
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    107. Primary biliary cirrhosis and the nuclear pore complex. Autoimmun Rev. 2012 Oct; 11(12):898-902. Duarte-Rey C, Bogdanos D, Yang CY, Roberts K, Leung PS, Anaya JM, Worman HJ, Gershwin ME. PMID: 22487189.
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    108. Animal models of primary biliary cirrhosis: materials and methods. Methods Mol Biol. 2012; 900:291-316. Leung PS, Yang GX, Dhirapong A, Tsuneyama K, Ridgway WM, Gershwin ME. PMID: 22933075.
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    109. IgM predominance in autoimmune disease: genetics and gender. Autoimmun Rev. 2012 May; 11(6-7):A404-12. Duarte-Rey C, Bogdanos DP, Leung PS, Anaya JM, Gershwin ME. PMID: 22178509.
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    110. Fine phenotypic and functional characterization of effector cluster of differentiation 8 positive T cells in human patients with primary biliary cirrhosis. Hepatology. 2011 Oct; 54(4):1293-302. Tsuda M, Ambrosini YM, Zhang W, Yang GX, Ando Y, Rong G, Tsuneyama K, Sumida K, Shimoda S, Bowlus CL, Leung PS, He XS, Coppel RL, Ansari AA, Lian ZX, Gershwin ME. PMID: 21735469.
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    111. The multi-hit hypothesis of primary biliary cirrhosis: polyinosinic-polycytidylic acid (poly I:C) and murine autoimmune cholangitis. Clin Exp Immunol. 2011 Oct; 166(1):110-20. Ambrosini YM, Yang GX, Zhang W, Tsuda M, Shu S, Tsuneyama K, Leung PS, Ansari AA, Coppel RL, Gershwin ME. PMID: 21910728.
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    112. A murine model of hepatitis B-associated hepatocellular carcinoma generated by adeno-associated virus-mediated gene delivery. Int J Oncol. 2011 Dec; 39(6):1511-9. Huang YH, Fang CC, Tsuneyama K, Chou HY, Pan WY, Shih YM, Wu PY, Chen Y, Leung PS, Gershwin ME, Tao MH. PMID: 21805030.
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    113. Electrophile-modified lipoic derivatives of PDC-E2 elicits anti-mitochondrial antibody reactivity. J Autoimmun. 2011 Nov; 37(3):209-16. Naiyanetr P, Butler JD, Meng L, Pfeiff J, Kenny TP, Guggenheim KG, Reiger R, Lam K, Kurth MJ, Ansari AA, Coppel RL, López-Hoyos M, Gershwin ME, Leung PS. PMID: 21763105.
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    114. Epithelial cell specificity and apotope recognition by serum autoantibodies in primary biliary cirrhosis. Hepatology. 2011 Jul; 54(1):196-203. Rong G, Zhong R, Lleo A, Leung PS, Bowlus CL, Yang GX, Yang CY, Coppel RL, Ansari AA, Cuebas DA, Worman HJ, Invernizzi P, Gores GJ, Norman G, He XS, Gershwin ME. PMID: 21488079.
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    115. Interaction between Toll-like receptors and natural killer cells in the destruction of bile ducts in primary biliary cirrhosis. Hepatology. 2011 Apr; 53(4):1270-81. Shimoda S, Harada K, Niiro H, Shirabe K, Taketomi A, Maehara Y, Tsuneyama K, Nakanuma Y, Leung P, Ansari AA, Gershwin ME, Akashi K. PMID: 21400555.
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    116. Innate immunity and primary biliary cirrhosis: activated invariant natural killer T cells exacerbate murine autoimmune cholangitis and fibrosis. Hepatology. 2011 Mar; 53(3):915-25. Wu SJ, Yang YH, Tsuneyama K, Leung PS, Illarionov P, Gershwin ME, Chuang YH. PMID: 21374662.
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    117. The effects of Spirulina on anemia and immune function in senior citizens. Cell Mol Immunol. 2011 May; 8(3):248-54. Selmi C, Leung PS, Fischer L, German B, Yang CY, Kenny TP, Cysewski GR, Gershwin ME. PMID: 21278762.
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    118. Autoimmune acute liver failure: proposed clinical and histological criteria. Hepatology. 2011 Feb; 53(2):517-26. Stravitz RT, Lefkowitch JH, Fontana RJ, Gershwin ME, Leung PS, Sterling RK, Manns MP, Norman GL, Lee WM. PMID: 21274872.
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    119. CD8 T cells mediate direct biliary ductule damage in nonobese diabetic autoimmune biliary disease. J Immunol. 2011 Jan 15; 186(2):1259-67. Yang GX, Wu Y, Tsukamoto H, Leung PS, Lian ZX, Rainbow DB, Hunter KM, Morris GA, Lyons PA, Peterson LB, Wicker LS, Gershwin ME, Ridgway WM. PMID: 21169553.
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    120. PBC screen: an IgG/IgA dual isotype ELISA detecting multiple mitochondrial and nuclear autoantibodies specific for primary biliary cirrhosis. J Autoimmun. 2010 Dec; 35(4):436-42. Liu H, Norman GL, Shums Z, Worman HJ, Krawitt EL, Bizzaro N, Vergani D, Bogdanos DP, Dalekos GN, Milkiewicz P, Czaja AJ, Heathcote EJ, Hirschfield GM, Tan EM, Miyachi K, Bignotto M, Battezzati PM, Lleo A, Leung PS, Podda M, Gershwin ME, Invernizzi P. PMID: 20932720.
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    121. The spectrum of autoantibodies in IPEX syndrome is broad and includes anti-mitochondrial autoantibodies. J Autoimmun. 2010 Nov; 35(3):265-8. Tsuda M, Torgerson TR, Selmi C, Gambineri E, Carneiro-Sampaio M, Mannurita SC, Leung PS, Norman GL, Gershwin ME. PMID: 20650610.
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    122. Dairy proteins and the response to pneumovax in senior citizens: a randomized, double-blind, placebo-controlled pilot study. Ann N Y Acad Sci. 2010 Mar; 1190:97-103. Freeman SL, Fisher L, German JB, Leung PS, Prince H, Selmi C, Naguwa SM, Gershwin ME. PMID: 20388140.
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    123. Development and validation of gene therapies in autoimmune diseases: Epidemiology to animal models. Autoimmun Rev. 2010 Mar; 9(5):A400-5. Leung PS, Shu SA, Kenny TP, Wu PY, Tao MH. PMID: 20035901.
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    124. Gene therapy in autoimmune diseases: challenges and opportunities. Autoimmun Rev. 2010 Jan; 9(3):170-4. Leung PS, Dhirapong A, Wu PY, Tao MH. PMID: 19854300.
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    125. Primary biliary cirrhosis is associated with altered hepatic microRNA expression. J Autoimmun. 2009 May-Jun; 32(3-4):246-53. Padgett KA, Lan RY, Leung PC, Lleo A, Dawson K, Pfeiff J, Mao TK, Coppel RL, Ansari AA, Gershwin ME. PMID: 19345069.
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    126. Induction of autoimmune cholangitis in non-obese diabetic (NOD).1101 mice following a chemical xenobiotic immunization. Clin Exp Immunol. 2009 Mar; 155(3):577-86. Wakabayashi K, Yoshida K, Leung PS, Moritoki Y, Yang GX, Tsuneyama K, Lian ZX, Hibi T, Ansari AA, Wicker LS, Ridgway WM, Coppel RL, Mackay IR, Gershwin ME. PMID: 19094117.
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    127. The immunological potential of galectin-1 and -3. Autoimmun Rev. 2009 Mar; 8(5):360-3. Dhirapong A, Lleo A, Leung P, Gershwin ME, Liu FT. PMID: 19064001.
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    128. Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease. Hepatology. 2008 Aug; 48(2):531-40. Wakabayashi K, Lian ZX, Leung PS, Moritoki Y, Tsuneyama K, Kurth MJ, Lam KS, Yoshida K, Yang GX, Hibi T, Ansari AA, Ridgway WM, Coppel RL, Mackay IR, Gershwin ME. PMID: 18563844.
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    129. Induction of shrimp tropomyosin-specific hypersensitivity in mice. Int Arch Allergy Immunol. 2008; 147(4):305-14. Leung PS, Lee YS, Tang CY, Kung WY, Chuang YH, Chiang BL, Fung MC, Chu KH. PMID: 18617750.
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    130. Liver autoimmunity triggered by microbial activation of natural killer T cells. Cell Host Microbe. 2008 May 15; 3(5):304-15. Mattner J, Savage PB, Leung P, Oertelt SS, Wang V, Trivedi O, Scanlon ST, Pendem K, Teyton L, Hart J, Ridgway WM, Wicker LS, Gershwin ME, Bendelac A. PMID: 18474357.
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    131. Antimitochondrial antibodies in acute liver failure: implications for primary biliary cirrhosis. Hepatology. 2007 Nov; 46(5):1436-42. Leung PS, Rossaro L, Davis PA, Park O, Tanaka A, Kikuchi K, Miyakawa H, Norman GL, Lee W, Gershwin ME. PMID: 17657817.
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    132. Induction of primary biliary cirrhosis in guinea pigs following chemical xenobiotic immunization. J Immunol. 2007 Aug 15; 179(4):2651-7. Leung PS, Park O, Tsuneyama K, Kurth MJ, Lam KS, Ansari AA, Coppel RL, Gershwin ME. PMID: 17675529.
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    133. A sensitive bead assay for antimitochondrial antibodies: Chipping away at AMA-negative primary biliary cirrhosis. Hepatology. 2007 Mar; 45(3):659-65. Oertelt S, Rieger R, Selmi C, Invernizzi P, Ansari AA, Coppel RL, Podda M, Leung PS, Gershwin ME. PMID: 17326160.
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    134. Identification of 2-nonynoic acid, a cosmetic component, as a potential trigger of primary biliary cirrhosis. J Autoimmun. 2006 Aug; 27(1):7-16. Rieger R, Leung PS, Jeddeloh MR, Kurth MJ, Nantz MH, Lam KS, Barsky D, Ansari AA, Coppel RL, Mackay IR, Gershwin ME. PMID: 16876981.
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    135. NOD.c3c4 congenic mice develop autoimmune biliary disease that serologically and pathogenetically models human primary biliary cirrhosis. J Exp Med. 2006 May 15; 203(5):1209-19. Irie J, Wu Y, Wicker LS, Rainbow D, Nalesnik MA, Hirsch R, Peterson LB, Leung PS, Cheng C, Mackay IR, Gershwin ME, Ridgway WM. PMID: 16636131.
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    136. Etiology of primary biliary cirrhosis: the search for the culprit. Semin Liver Dis. 2005 Aug; 25(3):327-36. Leung PS, Coppel RL, Gershwin ME. PMID: 16143948.
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    137. Analysis of the Foxp3/scurfin gene in Crohn's disease. Ann N Y Acad Sci. 2005 Jun; 1051:218-28. Park O, Grishina I, Leung PS, Gershwin ME, Prindiville T. PMID: 16126962.
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    138. Chemical xenobiotics and mitochondrial autoantigens in primary biliary cirrhosis: identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid. J Immunol. 2005 May 01; 174(9):5874-83. Amano K, Leung PS, Rieger R, Quan C, Wang X, Marik J, Suen YF, Kurth MJ, Nantz MH, Ansari AA, Lam KS, Zeniya M, Matsuura E, Coppel RL, Gershwin ME. PMID: 15845458.
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    139. Phylogenetic and immunological definition of four lipoylated proteins from Novosphingobium aromaticivorans, implications for primary biliary cirrhosis. J Autoimmun. 2005 May; 24(3):209-19. Padgett KA, Selmi C, Kenny TP, Leung PS, Balkwill DL, Ansari AA, Coppel RL, Gershwin ME. PMID: 15848043.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    140. Genetic polymorphisms influencing xenobiotic metabolism and transport in patients with primary biliary cirrhosis. Hepatology. 2005 Jan; 41(1):55-63. Kimura Y, Selmi C, Leung PS, Mao TK, Schauer J, Watnik M, Kuriyama S, Nishioka M, Ansari AA, Coppel RL, Invernizzi P, Podda M, Gershwin ME. PMID: 15690482.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    141. Seafood allergy: lessons from clinical symptoms, immunological mechanisms and molecular biology. Adv Biochem Eng Biotechnol. 2005; 97:205-35. Chu KH, Tang CY, Wu A, Leung PS. PMID: 16261809.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    142. Mitochondria and autoimmunity in primary biliary cirrhosis. Mitochondrion. 2004 Sep; 4(5-6):743-53. Ichiki Y, Leung PS, Ishibashi H, Coppel RL, Ansari AA, Gershwin ME. PMID: 16120429.
      View in: PubMed   Mentions: 1     Fields:    
    143. Xenobiotic-induced loss of tolerance in rabbits to the mitochondrial autoantigen of primary biliary cirrhosis is reversible. J Immunol. 2004 May 15; 172(10):6444-52. Amano K, Leung PS, Xu Q, Marik J, Quan C, Kurth MJ, Nantz MH, Ansari AA, Lam KS, Zeniya M, Coppel RL, Gershwin ME. PMID: 15128836.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    144. Caspase induction by IgA antimitochondrial antibody: IgA-mediated biliary injury in primary biliary cirrhosis. Hepatology. 2004 May; 39(5):1415-22. Matsumura S, Van De Water J, Leung P, Odin JA, Yamamoto K, Gores GJ, Mostov K, Ansari AA, Coppel RL, Shiratori Y, Gershwin ME. PMID: 15122771.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    145. Autoreactivity to lipoate and a conjugated form of lipoate in primary biliary cirrhosis. Gastroenterology. 2003 Dec; 125(6):1705-13. Bruggraber SF, Leung PS, Amano K, Quan C, Kurth MJ, Nantz MH, Benson GD, Van de Water J, Luketic V, Roche TE, Ansari AA, Coppel RL, Gershwin ME. PMID: 14724823.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    146. Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium. Hepatology. 2003 Nov; 38(5):1250-7. Selmi C, Balkwill DL, Invernizzi P, Ansari AA, Coppel RL, Podda M, Leung PS, Kenny TP, Van De Water J, Nantz MH, Kurth MJ, Gershwin ME. PMID: 14578864.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    147. Is there a relation between Chlamydia infection and primary biliary cirrhosis? Clin Dev Immunol. 2003 Jun-Dec; 10(2-4):227-33. Leung PS, Park O, Matsumura S, Ansari AA, Coppel RL, Gershwin ME. PMID: 14768955.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    148. Immunization with a xenobiotic 6-bromohexanoate bovine serum albumin conjugate induces antimitochondrial antibodies. J Immunol. 2003 May 15; 170(10):5326-32. Leung PS, Quan C, Park O, Van de Water J, Kurth MJ, Nantz MH, Ansari AA, Coppel RL, Lam KS, Gershwin ME. PMID: 12734383.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    149. Characterization of recombinant monoclonal IgA anti-PDC-E2 autoantibodies derived from patients with PBC. Hepatology. 2002 Dec; 36(6):1383-92. Fukushima N, Nalbandian G, Van De Water J, White K, Ansari AA, Leung P, Kenny T, Kamita SG, Hammock BD, Coppel RL, Stevenson F, Ishibashi H, Gershwin ME. PMID: 12447863.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    150. Differential expression of intestinal trefoil factor in biliary epithelial cells of primary biliary cirrhosis. Hepatology. 2002 Nov; 36(5):1227-35. Kimura Y, Leung PS, Kenny TP, Van De Water J, Nishioka M, Giraud AS, Neuberger J, Benson G, Kaul R, Ansari AA, Coppel RL, Gershwin ME. PMID: 12395334.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    151. Immunoglobulin gene usage and immunohistochemical characteristics of human monoclonal antibodies to the mitochondrial autoantigens of primary biliary cirrhosis induced in the XenoMouse. Hepatology. 2001 Oct; 34(4 Pt 1):631-7. Sasaki M, Van De Water J, Kenny TP, Gallo ML, Leung PS, Nakanuma Y, Ansari AA, Coppel RL, Neuberger J, Gershwin ME. PMID: 11584357.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCellsPHPublic Health
    152. Expression of bacterial beta-glucuronidase in human bile: an in vitro study. Gastrointest Endosc. 2001 Sep; 54(3):346-50. Leung JW, Liu YL, Leung PS, Chan RC, Inciardi JF, Cheng AF. PMID: 11522976.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    153. Genomic analysis of differentially expressed genes in liver and biliary epithelial cells of patients with primary biliary cirrhosis. J Autoimmun. 2001 Aug; 17(1):89-98. Tanaka A, Leung PS, Kenny TP, Au-Young J, Prindiville T, Coppel RL, Ansari AA, Gershwin ME. PMID: 11488641.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    154. cDNA cloning and molecular identification of the major oyster allergen from the Pacific oyster Crassostrea gigas. Clin Exp Allergy. 2001 Aug; 31(8):1287-94. Leung PS, Chu KH. PMID: 11529900.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    155. Fragment of Japanese encephalitis virus envelope protein produced in Escherichia coli protects mice from virus challenge. Microb Pathog. 2001 Jul; 31(1):9-19. Chia SC, Leung PS, Liao CP, Huang JH, Lee ST. PMID: 11427032.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    156. Primary biliary cirrhosis and autoimmunity: evaluating the genetic risk. Isr Med Assoc J. 2000 Dec; 2 Suppl:7-10. Gershwin ME, Leung PS, Li H, Seldin MF. PMID: 11344867.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    157. Mucosal immunity and primary biliary cirrhosis: presence of antimitochondrial antibodies in urine. Hepatology. 2000 Nov; 32(5):910-5. Tanaka A, Nalbandian G, Leung PS, Benson GD, Munoz S, Findor JA, Branch AD, Coppel RL, Ansari AA, Gershwin ME. PMID: 11050038.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    158. Tropomyosin Is the Major Mollusk Allergen: Reverse Transcriptase Polymerase Chain Reaction, Expression and IgE Reactivity. Mar Biotechnol (NY). 2000 Sep; 2(5):499-509. Chu KH, Wong SH, Leung PS. PMID: 11246417.
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    159. Comparative immunoreactivity of anti-trifluoroacetyl (TFA) antibody and anti-lipoic acid antibody in primary biliary cirrhosis: searching for a mimic. J Autoimmun. 2000 Aug; 15(1):51-60. Sasaki M, Ansari A, Pumford N, van de Water J, Leung PS, Humphries KM, Szweda LI, Nakanuma Y, Roche TE, Coppel RL, Bach JF, Gershwin ME. PMID: 10936028.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    160. Evidence for a locally driven mucosal response and the presence of mitochondrial antigens in saliva in primary biliary cirrhosis. Hepatology. 2000 Jan; 31(1):24-9. Reynoso-Paz S, Leung PS, Van De Water J, Tanaka A, Munoz S, Bass N, Lindor K, Donald PJ, Coppel RL, Ansari AA, Gershwin ME. PMID: 10613723.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    161. Seafood allergy: tropomyosins and beyond. J Microbiol Immunol Infect. 1999 Sep; 32(3):143-54. Leung PS, Chen YC, Chu KH. PMID: 10637712.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    162. Autoepitope mapping and reactivity of autoantibodies to the dihydrolipoamide dehydrogenase-binding protein (E3BP) and the glycine cleavage proteins in primary biliary cirrhosis. Hepatology. 1999 Apr; 29(4):1013-8. Dubel L, Tanaka A, Leung PS, Van de Water J, Coppel R, Roche T, Johanet C, Motokawa Y, Ansari A, Gershwin ME. PMID: 10094940.
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    163. Monoclonal antibodies to mitochondrial E2 components define autoepitopes in primary biliary cirrhosis. J Immunol. 1998 Nov 15; 161(10):5157-63. Migliaccio C, Nishio A, Van de Water J, Ansari AA, Leung PS, Nakanuma Y, Coppel RL, Gershwin ME. PMID: 9820485.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    164. Induction and persistence of immune-mediated cholangiohepatitis in neonatally thymectomized mice. Clin Immunol Immunopathol. 1998 Nov; 89(2):141-9. Masanaga T, Watanabe Y, Van de Water J, Leung PS, Nakanishi T, Kajiyama G, Ruebner BH, Coppel RL, Gershwin ME. PMID: 9787116.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    165. Identification and molecular characterization of Charybdis feriatus tropomyosin, the major crab allergen. J Allergy Clin Immunol. 1998 Nov; 102(5):847-52. Leung PS, Chen YC, Gershwin ME, Wong SH, Kwan HS, Chu KH. PMID: 9819304.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    166. Penetration and co-localization in MDCK cell mitochondria of IgA derived from patients with primary biliary cirrhosis. J Autoimmun. 1998 Oct; 11(5):573-80. Malmborg AC, Shultz DB, Luton F, Mostov KE, Richly E, Leung PS, Benson GD, Ansari AA, Coppel RL, Gershwin ME, Van de Water J. PMID: 9802945.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    167. Molecular and immunological characterization of shellfish allergens. Front Biosci. 1998 Mar 15; 3:d306-12. Leung PS, Chu KH. PMID: 9482714.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    168. Molecular identification of the lobster muscle protein tropomyosin as a seafood allergen. Mol Mar Biol Biotechnol. 1998 Mar; 7(1):12-20. Leung PS, Chen YC, Mykles DL, Chow WK, Li CP, Chu KH. PMID: 9597774.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    169. Clinicopathological study of primary biliary cirrhosis negative for antimitochondrial antibodies. Liver. 1997 Dec; 17(6):281-7. Nakanuma Y, Harada K, Kaji K, Terasaki S, Tsuneyama K, Moteki S, Van de Water J, Leung PS, Gershwin ME. PMID: 9455733.
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    170. Persistence of autoantibodies against recombinant mitochondrial and nuclear pore proteins after orthotopic liver transplantation for primary biliary cirrhosis. J Autoimmun. 1997 Oct; 10(5):491-7. Mattalia A, Lüttig B, Rosina F, Leung PS, Van de Water J, Bauducci M, Ciancio A, Böker KH, Worman H, Cooper RL, Manns M, Ansari A, Rizzetto M, Gershwin ME. PMID: 9376077.
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    171. Comparative studies of antimitochondrial autoantibodies in sera and bile in primary biliary cirrhosis. Hepatology. 1997 May; 25(5):1085-9. Nishio A, Van de Water J, Leung PS, Joplin R, Neuberger JM, Lake J, Björkland A, Tötterman TH, Peters M, Worman HJ, Ansari AA, Coppel RL, Gershwin ME. PMID: 9141421.
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    172. In situ nucleic acid hybridization of cytokines in primary biliary cirrhosis: predominance of the Th1 subset. Hepatology. 1997 Apr; 25(4):791-6. Harada K, Van de Water J, Leung PS, Coppel RL, Ansari A, Nakanuma Y, Gershwin ME. PMID: 9096578.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    173. Antimitochondrial antibodies in primary biliary cirrhosis. Semin Liver Dis. 1997 Feb; 17(1):61-9. Leung PS, Coppel RL, Ansari A, Munoz S, Gershwin ME. PMID: 9089911.
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    174. Quantitative measurement of autoantibodies to recombinant mitochondrial antigens in patients with primary biliary cirrhosis: relationship of levels of autoantibodies to disease progression. Hepatology. 1997 Jan; 25(1):6-11. Van Norstrand MD, Malinchoc M, Lindor KD, Therneau TM, Gershwin ME, Leung PS, Dickson ER, Homburger HA. PMID: 8985257.
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    175. In situ nucleic acid hybridization of pyruvate dehydrogenase complex-E2 in primary biliary cirrhosis: pyruvate dehydrogenase complex-E2 messenger RNA is expressed in hepatocytes but not in biliary epithelium. Hepatology. 1997 Jan; 25(1):27-32. Harada K, Van de Water J, Leung PS, Coppel RL, Nakanuma Y, Gershwin ME. PMID: 8985260.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    176. Inhibition of PDC-E2 human combinatorial autoantibodies by peptide mimotopes. J Autoimmun. 1996 Dec; 9(6):785-93. Leung PS, Cha S, Joplin RE, Galperin C, Van de Water J, Ansari AA, Coppel RL, Schatz PJ, Cwirla S, Fabris LE, Neuberger JM, Gershwin ME. PMID: 9115581.
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    177. IgE reactivity against a cross-reactive allergen in crustacea and mollusca: evidence for tropomyosin as the common allergen. J Allergy Clin Immunol. 1996 Nov; 98(5 Pt 1):954-61. Leung PS, Chow WK, Duffey S, Kwan HS, Gershwin ME, Chu KH. PMID: 8939159.
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    178. Random phage mimotopes recognized by monoclonal antibodies against the pyruvate dehydrogenase complex-E2 (PDC-E2). Proc Natl Acad Sci U S A. 1996 Oct 01; 93(20):10949-54. Cha S, Leung PS, Van de Water J, Tsuneyama K, Joplin RE, Ansari AA, Nakanuma Y, Schatz PJ, Cwirla S, Fabris LE, Neuberger JM, Gershwin ME, Coppel RL. PMID: 8855289.
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    179. Use of a designer triple expression hybrid clone for three different lipoyl domain for the detection of antimitochondrial autoantibodies. Hepatology. 1996 Jul; 24(1):97-103. Moteki S, Leung PS, Coppel RL, Dickson ER, Kaplan MM, Munoz S, Gershwin ME. PMID: 8707289.
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    180. Molecular aspects and the pathological basis of primary biliary cirrhosis. J Autoimmun. 1996 Apr; 9(2):119-28. Leung PS, Van de Water J, Coppel RL, Nakanuma Y, Munoz S, Gershwin ME. PMID: 8738955.
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    181. Epitope mapping and reactivity of autoantibodies to the E2 component of 2-oxoglutarate dehydrogenase complex in primary biliary cirrhosis using recombinant 2-oxoglutarate dehydrogenase complex. Hepatology. 1996 Mar; 23(3):436-44. Moteki S, Leung PS, Dickson ER, Van Thiel DH, Galperin C, Buch T, Alarcon-Segovia D, Kershenobich D, Kawano K, Coppel RL. PMID: 8617422.
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    182. Molecular biology of autoantigens in rheumatic diseases. Rheum Dis Clin North Am. 1996 Feb; 22(1):175-210. Galperin C, Leung PS, Gershwin ME. PMID: 8907071.
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    183. Autoantibodies to BCOADC-E2 in patients with primary biliary cirrhosis recognize a conformational epitope. Hepatology. 1995 Aug; 22(2):505-13. Leung PS, Chuang DT, Wynn RM, Cha S, Danner DJ, Ansari A, Coppel RL, Gershwin ME. PMID: 7543435.
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    184. Abnormal expression of the E2 component of the pyruvate dehydrogenase complex on the luminal surface of biliary epithelium occurs before major histocompatibility complex class II and BB1/B7 expression. Hepatology. 1995 Apr; 21(4):1031-7. Tsuneyama K, Van de Water J, Leung PS, Cha S, Nakanuma Y, Kaplan M, De Lellis R, Coppel R, Ansari A, Gershwin ME. PMID: 7535733.
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    185. Epitope mapping of the branched chain alpha-ketoacid dehydrogenase dihydrolipoyl transacylase (BCKD-E2) protein that reacts with sera from patients with idiopathic dilated cardiomyopathy. J Immunol. 1994 Nov 15; 153(10):4754-65. Ansari AA, Neckelmann N, Villinger F, Leung P, Danner DJ, Brar SS, Zhao S, Gravanis MB, Mayne A, Gershwin ME. PMID: 7963542.
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    186. Cloning, expression, and primary structure of Metapenaeus ensis tropomyosin, the major heat-stable shrimp allergen. J Allergy Clin Immunol. 1994 Nov; 94(5):882-90. Leung PS, Chu KH, Chow WK, Ansari A, Bandea CI, Kwan HS, Nagy SM, Gershwin ME. PMID: 7963157.
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    187. Heterogeneity of combinatorial human autoantibodies against PDC-E2 and biliary epithelial cells in patients with primary biliary cirrhosis. Hepatology. 1994 Sep; 20(3):574-83. Cha S, Leung PS, Coppel RL, Van de Water J, Ansari AA, Gershwin ME. PMID: 7521314.
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    188. Nucleotide sequence analysis of natural and combinatorial anti-PDC-E2 antibodies in patients with primary biliary cirrhosis. Recapitulating immune selection with molecular biology. J Immunol. 1994 Mar 01; 152(5):2577-85. Pascual V, Cha S, Gershwin ME, Capra JD, Leung PS. PMID: 8133065.
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    189. Evaluation of possible histamine release from human peripheral blood cells using an enzyme immunoassay (HRT) with components of intravenous catheters. Allerg Immunol (Paris). 1993 Oct; 25(8):346-53. Leung PS, Halpern GM, Gershwin ME. PMID: 7505586.
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    190. Comparative metabolism and structure of BCKD-E2 in primary biliary cirrhosis. J Autoimmun. 1993 Aug; 6(4):459-66. Turchany JM, Leung PS, Iwayama T, Jefferson DM, Ishida J, Yamaguchi M, Munoz S, Danner DJ, Dickson ER, Gershwin ME. PMID: 8216688.
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    191. Molecular mimicry in primary biliary cirrhosis. Evidence for biliary epithelial expression of a molecule cross-reactive with pyruvate dehydrogenase complex-E2. J Clin Invest. 1993 Jun; 91(6):2653-64. Van de Water J, Turchany J, Leung PS, Lake J, Munoz S, Surh CD, Coppel R, Ansari A, Nakanuma Y, Gershwin ME. PMID: 8514873.
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    192. Combinatorial autoantibodies to dihydrolipoamide acetyltransferase, the major autoantigen of primary biliary cirrhosis. Proc Natl Acad Sci U S A. 1993 Mar 15; 90(6):2527-31. Cha S, Leung PS, Gershwin ME, Fletcher MP, Ansari AA, Coppel RL. PMID: 8460168.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    193. Immunoglobulin genes in autoimmunity. Int Arch Allergy Immunol. 1993; 101(2):113-8. Leung PS, Gershwin ME. PMID: 8508048.
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    194. Chromosome localization and RFLP analysis of PDC-E2: the major autoantigen of primary biliary cirrhosis. Autoimmunity. 1993; 14(4):335-40. Leung PS, Watanabe Y, Munoz S, Teuber SS, Patel MS, Korenberg JR, Hara P, Coppel R, Gershwin ME. PMID: 8102256.
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    195. Characterization and epitope mapping of human monoclonal antibodies to PDC-E2, the immunodominant autoantigen of primary biliary cirrhosis. J Autoimmun. 1992 Dec; 5(6):703-18. Leung PS, Krams S, Munoz S, Surh CP, Ansari A, Kenny T, Robbins DL, Fung J, Starzl TE, Maddrey W. PMID: 1283300.
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    196. M4 and M9 antibodies in the overlap syndrome of primary biliary cirrhosis and chronic active hepatitis: epitopes or epiphenomena? Hepatology. 1992 Nov; 16(5):1128-36. Davis PA, Leung P, Manns M, Kaplan M, Munoz SJ, Gorin FA, Dickson ER, Krawitt E, Coppel R, Gershwin ME. PMID: 1330864.
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    197. Antimitochondrial antibodies in kindreds of patients with primary biliary cirrhosis: antimitochondrial antibodies are unique to clinical disease and are absent in asymptomatic family members. Hepatology. 1992 Oct; 16(4):899-905. Caldwell SH, Leung PS, Spivey JR, Prindiville T, de Medina M, Saicheur T, Rowley M, Reddy KR, Coppel R, Jeffers LJ. PMID: 1398496.
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    198. Use of designer recombinant mitochondrial antigens in the diagnosis of primary biliary cirrhosis. Hepatology. 1992 Mar; 15(3):367-72. Leung PS, Iwayama T, Prindiville T, Chuang DT, Ansari AA, Wynn RM, Dickson R, Coppel R, Gershwin ME. PMID: 1371979.
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    199. Molecular biology of the 2-oxo-acid dehydrogenase complexes and anti-mitochondrial antibodies. Prog Liver Dis. 1992; 10:47-61. Gershwin ME, Rowley M, Davis PA, Leung P, Coppel R, Mackay IR. PMID: 1296237.
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    200. Comparative immunoreactive profiles of Japanese and American patients with primary biliary cirrhosis against mitochondrial autoantigens. Int Arch Allergy Immunol. 1992; 99(1):28-33. Iwayama T, Leung PS, Rowley M, Munoz S, Nishioka M, Nakagawa T, Dickson ER, Coppel RL, Mackay IR, Gershwin ME. PMID: 1483064.
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    201. The identification and cloning of the murine genes encoding the liver specific F alloantigens. J Autoimmun. 1991 Dec; 4(6):857-70. Teuber SS, Coppel RL, Ansari AA, Leung PS, Neve R, Mackay IR, Gershwin ME. PMID: 1667467.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    202. Specific reactivity of recombinant human PDC-E1 alpha in primary biliary cirrhosis. J Autoimmun. 1991 Oct; 4(5):769-78. Iwayama T, Leung PS, Coppel RL, Roche TE, Patel MS, Mizushima Y, Nakagawa T, Dickson R, Gershwin ME. PMID: 1797026.
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    203. The immunobiology of heat shock proteins. J Investig Allergol Clin Immunol. 1991 Feb; 1(1):23-30. Leung PS, Gershwin ME. PMID: 1669561.
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    204. Molecular characterization of the mitochondrial autoantigens in primary biliary cirrhosis. Immunol Res. 1991; 10(3-4):518-27. Leung PS, Van de Water J, Coppel RL, Gershwin ME. PMID: 1720161.
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    205. Site-directed mutagenesis of lysine within the immunodominant autoepitope of PDC-E2. Hepatology. 1990 Dec; 12(6):1321-8. Leung PS, Iwayama T, Coppel RL, Gershwin ME. PMID: 1701753.
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    206. Sjögren's syndrome and primary biliary cirrhosis: presence of autoantibodies to purified mitochondrial 2-OXO acid dehydrogenases. J Rheumatol. 1990 Nov; 17(11):1453-7. Fujikura S, Davis PA, Prindiville T, Leung P, Fox RI, Gershwin ME. PMID: 1703233.
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    207. Molecular definitions, autoepitopes, and enzymatic activities of the mitochondrial autoantigens of primary biliary cirrhosis. Semin Liver Dis. 1989 May; 9(2):132-7. Van de Water J, Surh CD, Leung PS, Krams SM, Fregeau D, Davis P, Coppel R, Mackay IR, Gershwin ME. PMID: 2471277.
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    208. The molecular structure of autoantigens. Curr Opin Immunol. 1989-1990 Apr; 2(4):567-75. Leung PS, Gershwin ME. PMID: 2700899.
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    209. Autoantibodies of primary biliary cirrhosis recognize dihydrolipoamide acetyltransferase and inhibit enzyme function. J Immunol. 1988 Oct 01; 141(7):2321-4. Van de Water J, Fregeau D, Davis P, Ansari A, Danner D, Leung P, Coppel R, Gershwin ME. PMID: 3049806.
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    210. The autoepitope of the 74-kD mitochondrial autoantigen of primary biliary cirrhosis corresponds to the functional site of dihydrolipoamide acetyltransferase. J Exp Med. 1988 Jun 01; 167(6):1791-9. Van de Water J, Gershwin ME, Leung P, Ansari A, Coppel RL. PMID: 2455013.
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