Mark J Kurth

Title(s)Professor Emeritus, Chemistry
SchoolUniversity of California, Davis
Address5467 Chemistry Annex
CA 95616
Phone(530)554-2145
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. E. coli and the etiology of human PBC: Antimitochondrial antibodies and spreading determinants. Hepatology. 2022 02; 75(2):266-279. Yang Y, Choi J, Chen Y, Invernizzi P, Yang G, Zhang W, Shao TH, Jordan F, Nemeria NS, Coppel RL, Ridgway WM, Kurth M, Ansari AA, Leung PSC, Gershwin ME, Yang Y, Choi J, Chen Y, Yang G, Zhang W, Shao TH, Jordan F, Nemeria NS, Coppel RL, Ridgway WM, Kurth M, Leung PSC, Gershwin ME. PMID: 34608663.
      View in: PubMed   Mentions:    Fields:    
    2. Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma. J Exp Med. 2021 10 04; 218(10). Paillet J, Plantureux C, Lévesque S, Le Naour J, Stoll G, Sauvat A, Caudana P, Tosello Boari J, Bloy N, Lachkar S, Martins I, Opolon P, Checcoli A, Delaune A, Robil N, de la Grange P, Hamroune J, Letourneur F, Autret G, Leung PSC, Gershwin ME, Zhu JS, Kurth MJ, Lekbaby B, Augustin J, Kim Y, Gujar S, Coulouarn C, Fouassier L, Zitvogel L, Piaggio E, Housset C, Soussan P, Maiuri MC, Kroemer G, Pol JG. PMID: 34495298; PMCID: PMC8429038.
      View in: PubMed   Mentions: 1     Fields:    
    3. Heterocycles as a Peptidomimetic Scaffold: Solid-Phase Synthesis Strategies. Pharmaceuticals (Basel). 2021 May 10; 14(5). Abdildinova A, Kurth MJ, Gong YD. PMID: 34068671; PMCID: PMC8151782.
      View in: PubMed   Mentions:
    4. Davis-Beirut Reaction Inspired Nitroso Diels-Alder Reaction. Tetrahedron Lett. 2021 Apr 13; 69. Son JH, Cheung A, Zhu JS, Haddadin MJ, Kurth MJ. PMID: 33854257; PMCID: PMC8039969.
      View in: PubMed   Mentions:    Fields:    
    5. 1-BENZYLSPIRO[PIPERIDINE-4,1'-PYRIDO[3,4-b]indole] 'co-potentiators' for minimal function CFTR mutants. Eur J Med Chem. 2021 Jan 01; 209:112888. Son JH, Phuan PW, Zhu JS, Lipman E, Cheung A, Tsui KY, Tantillo DJ, Verkman AS, Haggie PM, Kurth MJ. PMID: 33092904; PMCID: PMC7744356.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. A Redox Isomerization Strategy for Accessing Modular Azobenzene Photoswitches with Near Quantitative Bidirectional Photoconversion. Org Lett. 2019 11 01; 21(21):8765-8770. Zhu JS, Larach JM, Tombari RJ, Gingrich PW, Bode SR, Tuck JR, Warren HT, Son JH, Duim WC, Fettinger JC, Haddadin MJ, Tantillo DJ, Kurth MJ, Olson DE. PMID: 31638403; PMCID: PMC7158698.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    7. Davis-Beirut Reaction: A Photochemical Brønsted Acid Catalyzed Route to N-Aryl 2H-Indazoles. Org Lett. 2019 08 02; 21(15):6058-6062. Kraemer N, Li CJ, Zhu JS, Larach JM, Tsui KY, Tantillo DJ, Haddadin MJ, Kurth MJ. PMID: 31339318; PMCID: PMC6698363.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    8. Davis-Beirut Reaction: Diverse Chemistries of Highly Reactive Nitroso Intermediates in Heterocycle Synthesis. Acc Chem Res. 2019 08 20; 52(8):2256-2265. Zhu JS, Haddadin MJ, Kurth MJ. PMID: 31328502; PMCID: PMC6702092.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    9. Synthesis and evaluation of tetrahydropyrazolopyridine inhibitors of anion exchange protein SLC26A4 (pendrin). Bioorg Med Chem Lett. 2019 08 15; 29(16):2119-2123. Zhu JS, Lu JY, Tan JA, Rivera AA, Phuan PW, Shatskikh ME, Son JH, Haggie PM, Verkman AS, Kurth MJ. PMID: 31281021; PMCID: PMC6690761.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. Accessing Multiple Classes of 2 H-Indazoles: Mechanistic Implications for the Cadogan and Davis-Beirut Reactions. J Am Chem Soc. 2019 04 17; 141(15):6247-6253. Zhu JS, Li CJ, Tsui KY, Kraemer N, Son JH, Haddadin MJ, Tantillo DJ, Kurth MJ. PMID: 30912441; PMCID: PMC6705401.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    11. Novel 2-(5-Imino-5H-isoquinolones[3,4-b]quinoxalin-7-ylmethyl)-benzonitrile (DIQ3) and Other Related Derivatives Targeting Colon Cancer Cells: Syntheses and in Vitro Models. ACS Omega. 2019 Feb 28; 4(2):3205-3212. Monzer A, Jabotian N, Ballout F, Zhu JS, Kurth MJ, Haddadin MJ, Gali-Muhtasib H. PMID: 30842984; PMCID: PMC6396124.
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    12. Photochemical Preparation of 1,2-Dihydro-3 H-indazol-3-ones in Aqueous Solvent at Room Temperature. J Org Chem. 2018 12 21; 83(24):15493-15498. Zhu JS, Kraemer N, Li CJ, Haddadin MJ, Kurth MJ. PMID: 30468072; PMCID: PMC6467708.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    13. N-N Bond Formation between Primary Amines and Nitrosos: Direct Synthesis of 2-Substituted Indazolones with Mechanistic Insights. Org Lett. 2018 08 17; 20(16):4736-4739. Zhu JS, Kraemer N, Shatskikh ME, Li CJ, Son JH, Haddadin MJ, Tantillo DJ, Kurth MJ. PMID: 30067041; PMCID: PMC6451655.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    14. Combination potentiator ('co-potentiator') therapy for CF caused by CFTR mutants, including N1303K, that are poorly responsive to single potentiators. J Cyst Fibros. 2018 09; 17(5):595-606. Phuan PW, Son JH, Tan JA, Li C, Musante I, Zlock L, Nielson DW, Finkbeiner WE, Kurth MJ, Galietta LJ, Haggie PM, Verkman AS. PMID: 29903467; PMCID: PMC6436558.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    15. Davis-Beirut Reaction: Alkoxide versus Hydroxide Addition to the Key o-Nitrosoimine Intermediate. Org Lett. 2018 03 02; 20(5):1308-1311. Zhu JS, Duong MR, Teuthorn AP, Lu JY, Son JH, Haddadin MJ, Kurth MJ. PMID: 29431446; PMCID: PMC6485925.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    16. Correction to "Diverting Reactive Intermediates Toward Unusual Chemistry: Unexpected Anthranil Products from Davis-Beirut Reaction". J Org Chem. 2017 12 01; 82(23):12946. Zhu JS, Son JH, Teuthorn AP, Haddadin MJ, Kurth MJ, Tantillo DJ. PMID: 29091433.
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    17. Diverting Reactive Intermediates Toward Unusual Chemistry: Unexpected Anthranil Products from Davis-Beirut Reaction. J Org Chem. 2017 10 20; 82(20):10875-10882. Zhu JS, Son JH, Teuthorn AP, Haddadin MJ, Kurth MJ, Tantillo DJ. PMID: 28922917; PMCID: PMC5897912.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    18. The fingerprint of antimitochondrial antibodies and the etiology of primary biliary cholangitis. Hepatology. 2017 05; 65(5):1670-1682. Shuai Z, Wang J, Badamagunta M, Choi J, Yang G, Zhang W, Kenny TP, Guggenheim K, Kurth MJ, Ansari AA, Voss J, Coppel RL, Invernizzi P, Leung PSC, Gershwin ME. PMID: 28100006; PMCID: PMC5397331.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    19. High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators. J Med Chem. 2017 03 23; 60(6):2401-2410. Son JH, Zhu JS, Phuan PW, Cil O, Teuthorn AP, Ku CK, Lee S, Verkman AS, Kurth MJ. PMID: 28230981; PMCID: PMC5463557.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    20. Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation. Transl Res. 2017 04; 182:14-26.e4. Cil O, Phuan PW, Son JH, Zhu JS, Ku CK, Tabib NA, Teuthorn AP, Ferrera L, Zachos NC, Lin R, Galietta LJV, Donowitz M, Kurth MJ, Verkman AS. PMID: 27815136; PMCID: PMC5453637.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    21. One-Pot Synthesis of Benzo[4,5]imidazo[2,1-a]isoquinolines and Isoquinolino[3,4-b]quinoxalines via Tandem Cyclization Strategies. J Org Chem. 2016 05 06; 81(9):3924-8. Bagdasarian AL, Nguyen HH, Palazzo TA, Fettinger JC, Haddadin MJ, Kurth MJ. PMID: 27030441; PMCID: PMC6688609.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    22. Dibenzonaphthyridinones: Heterocycle-to-Heterocycle Synthetic Strategies and Photophysical Studies. Org Lett. 2015 Dec 04; 17(23):5732-5. Palazzo TA, Patra D, Yang JS, El Khoury E, Appleton MG, Haddadin MJ, Tantillo DJ, Kurth MJ. PMID: 26574652; PMCID: PMC4816217.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    23. Expedient one-pot synthesis of indolo[3,2-c]isoquinolines via a base-promoted N-alkylation/tandem cyclization. Tetrahedron Lett. 2015 Sep 30; 56(40):5429-5433. Nguyen HH, Fettinger JC, Haddadin MJ, Kurth MJ. PMID: 26366017; PMCID: PMC4564870.
      View in: PubMed   Mentions: 1     Fields:    
    24. Predicting hydration propensities of biologically relevant α-ketoamides. Bioorg Med Chem Lett. 2015 Oct 01; 25(19):4153-7. Wedler HB, Palazzo TA, Pemberton RP, Hamann CS, Kurth MJ, Tantillo DJ. PMID: 26306983.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    25. Heterocycle-to-Heterocycle Route to Quinoline-4-amines: Reductive Heterocyclization of 3-(2-Nitrophenyl)isoxazoles. European J Org Chem. 2014 Dec; 2014(34):7651-7657. Coffman KC, Duong V, Bagdasarian AL, Fettinger JC, Haddadin MJ, Kurth MJ. PMID: 26257574; PMCID: PMC4524663.
      View in: PubMed   Mentions: 2  
    26. Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrins αvβ3, α4β1, and α5β1. J Biol Chem. 2015 Jan 02; 290(1):259-71. Fujita M, Zhu K, Fujita CK, Zhao M, Lam KS, Kurth MJ, Takada YK, Takada Y. PMID: 25398877; PMCID: PMC4281730.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    27. ΔF508-CFTR correctors: synthesis and evaluation of thiazole-tethered imidazolones, oxazoles, oxadiazoles, and thiadiazoles. Bioorg Med Chem Lett. 2014 Dec 15; 24(24):5840-5844. Ye L, Hu B, El-Badri F, Hudson BM, Phuan PW, Verkman AS, Tantillo DJ, Kurth MJ. PMID: 25452003; PMCID: PMC4255153.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    28. Inhibition of myeloperoxidase: evaluation of 2H-indazoles and 1H-indazolones. Bioorg Med Chem. 2014 Nov 15; 22(22):6422-9. Roth A, Ott S, Farber KM, Palazzo TA, Conrad WE, Haddadin MJ, Tantillo DJ, Cross CE, Eiserich JP, Kurth MJ. PMID: 25438766; PMCID: PMC4254468.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    29. Halothane-induced hepatitis: paradigm or paradox for drug-induced liver injury. Hepatology. 2014 Nov; 60(5):1473-5. Kurth MJ, Yokoi T, Gershwin ME. PMID: 24913773; PMCID: PMC4211967.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    30. Constrained bithiazoles: small molecule correctors of defective ΔF508-CFTR protein trafficking. J Med Chem. 2014 Aug 14; 57(15):6729-38. Coffman KC, Nguyen HH, Phuan PW, Hudson BM, Yu GJ, Bagdasarian AL, Montgomery D, Lodewyk MW, Yang B, Yoo CL, Verkman AS, Tantillo DJ, Kurth MJ. PMID: 25061695; PMCID: PMC4136667.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    31. Davis-Beirut reaction: route to thiazolo-, thiazino-, and thiazepino-2H-indazoles. J Org Chem. 2014 Aug 01; 79(15):6939-45. Farber KM, Haddadin MJ, Kurth MJ. PMID: 25019525; PMCID: PMC4120971.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    32. Cyclic azacyanines: experimental and computational studies on spectroscopic properties and unique reactivity. J Fluoresc. 2014 Jul; 24(4):1285-96. Patra D, Palazzo TA, Malaeb NN, Haddadin MJ, Tantillo DJ, Kurth MJ. PMID: 24910112.
      View in: PubMed   Mentions: 2     Fields:    
    33. Facile one-pot assembly of imidazotriazolobenzodiazepines via indium(III)-catalyzed multicomponent reactions. Org Lett. 2013 Sep 06; 15(17):4492-5. Nguyen HH, Palazzo TA, Kurth MJ. PMID: 23961714; PMCID: PMC3850773.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    34. Antimitochondrial antibody recognition and structural integrity of the inner lipoyl domain of the E2 subunit of pyruvate dehydrogenase complex. J Immunol. 2013 Sep 01; 191(5):2126-33. Wang J, Budamagunta MS, Voss JC, Kurth MJ, Lam KS, Lu L, Kenny TP, Bowlus C, Kikuchi K, Coppel RL, Ansari AA, Gershwin ME, Leung PS. PMID: 23894195; PMCID: PMC3759514.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    35. ABSOLUTE CONFIGURATION AND BIOLOGICAL PROPERTIES OF ENANTIOMERS OF CFTR INHIBITOR BPO-27. ACS Med Chem Lett. 2013 May 09; 4(5):456-459. Snyder DS, Tradtrantip L, Battula S, Yao C, Phuan PW, Fettinger JC, Kurth MJ, Verkman AS. PMID: 23814642; PMCID: PMC3694630.
      View in: PubMed   Mentions: 5  
    36. Heterocycle-heterocycle strategies: (2-nitrophenyl)isoxazole precursors to 4-aminoquinolines, 1H-indoles, and quinolin-4(1H)-ones. Org Lett. 2013 Apr 19; 15(8):2062-5. Coffman KC, Palazzo TA, Hartley TP, Fettinger JC, Tantillo DJ, Kurth MJ. PMID: 23557405; PMCID: PMC3643507.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    37. Antimitochondrial antibody heterogeneity and the xenobiotic etiology of primary biliary cirrhosis. Hepatology. 2013 Apr; 57(4):1498-508. Chen RC, Naiyanetr P, Shu SA, Wang J, Yang GX, Kenny TP, Guggenheim KC, Butler JD, Bowlus C, Tao MH, Kurth MJ, Ansari AA, Kaplan M, Coppel RL, Lleo A, Gershwin ME, Leung PS. PMID: 23184636; PMCID: PMC3601563.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    38. Environment and primary biliary cirrhosis: electrophilic drugs and the induction of AMA. J Autoimmun. 2013 Mar; 41:79-86. Leung PS, Wang J, Naiyanetr P, Kenny TP, Lam KS, Kurth MJ, Gershwin ME. PMID: 23352659; PMCID: PMC3622763.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    39. Microwave-assisted synthesis of 3-nitroindoles from N-aryl enamines via intramolecular arene-alkene coupling. Org Lett. 2013 Jan 18; 15(2):362-5. Nguyen HH, Kurth MJ. PMID: 23268775; PMCID: PMC3549302.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    40. Identification of inhibitors against interaction between pro-inflammatory sPLA2-IIA protein and integrin αvβ3. Bioorg Med Chem Lett. 2013 Jan 01; 23(1):340-5. Ye L, Dickerson T, Kaur H, Takada YK, Fujita M, Liu R, Knapp JM, Lam KS, Schore NE, Kurth MJ, Takada Y. PMID: 23164706; PMCID: PMC4570851.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    41. The Davis-Beirut Reaction: a novel entry into 2H-indazoles and indazolones. Recent biological activity of indazoles. Mini Rev Med Chem. 2012 Oct; 12(12):1293-300. Haddadin MJ, Conrad WE, Kurth MJ. PMID: 23092440.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    42. Multicomponent assembly of highly substituted indoles by dual palladium-catalyzed coupling reactions. Angew Chem Int Ed Engl. 2012 Oct 15; 51(42):10588-91. Knapp JM, Zhu JS, Tantillo DJ, Kurth MJ. PMID: 23001913; PMCID: PMC3517165.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    43. Acid and base catalyzed Davis-Beirut reaction: experimental and theoretical mechanistic studies and synthesis of novel 3-amino-2H-indazoles. Tetrahedron Lett. 2012 Nov 28; 53(48):6475-6478. Avila B, El-Dakdouki MH, Nazer MZ, Harrison JG, Tantillo DJ, Haddadin MJ, Kurth MJ. PMID: 23139435; PMCID: PMC3489190.
      View in: PubMed   Mentions: 4     Fields:    
    44. Xenobiotics and autoimmunity: does acetaminophen cause primary biliary cirrhosis? Trends Mol Med. 2012 Oct; 18(10):577-82. Leung PS, Lam K, Kurth MJ, Coppel RL, Gershwin ME. PMID: 22920894; PMCID: PMC3465509.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    45. A one-pot-three-step route to triazolotriazepinoindazolones from oxazolino-2H-indazoles. Org Lett. 2012 Aug 03; 14(15):3870-3. Conrad WE, Rodriguez KX, Nguyen HH, Fettinger JC, Haddadin MJ, Kurth MJ. PMID: 22823414; PMCID: PMC3427757.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    46. Triazolbenzo[d]thiazoles: efficient synthesis and biological evaluation as neuroprotective agents. Bioorg Med Chem Lett. 2012 Sep 15; 22(18):5976-8. Avila B, Roth A, Streets H, Dwyer DS, Kurth MJ. PMID: 22892117; PMCID: PMC3432163.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    47. Unusual Friedlander reactions: a route to novel quinoxaline-based heterocycles. Org Lett. 2012 Jul 20; 14(14):3704-7. Shoker TA, Ghattass KI, Fettinger JC, Kurth MJ, Haddadin MJ. PMID: 22783916; PMCID: PMC3492540.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    48. Click-based synthesis of triazolobithiazole ΔF508-CFTR correctors for cystic fibrosis. Bioorg Med Chem. 2012 Sep 01; 20(17):5247-53. Donald MB, Rodriguez KX, Shay H, Phuan PW, Verkman AS, Kurth MJ. PMID: 22841006; PMCID: PMC3419814.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    49. 7-Substituted 8-aza-7-deazaadenosines for modification of the siRNA major groove. Org Biomol Chem. 2012 Aug 28; 10(32):6491-7. Ibarra-Soza JM, Morris AA, Jayalath P, Peacock H, Conrad WE, Donald MB, Kurth MJ, Beal PA. PMID: 22766576; PMCID: PMC3417767.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    50. One-pot, two-step cascade synthesis of quinazolinotriazolobenzodiazepines. Org Lett. 2012 Jul 20; 14(14):3732-5. Guggenheim KG, Toru H, Kurth MJ. PMID: 22746550; PMCID: PMC3486955.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    51. Isoxazolodihydropyridinones: 1,3-dipolar cycloaddition of nitrile oxides onto 2,4-dioxopiperidines. ACS Comb Sci. 2012 Apr 09; 14(4):280-4. Coffman KC, Hartley TP, Dallas JL, Kurth MJ. PMID: 22352295; PMCID: PMC3345193.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    52. Structure-activity relationships of cyanoquinolines with corrector-potentiator activity in ΔF508 cystic fibrosis transmembrane conductance regulator protein. J Med Chem. 2012 Feb 09; 55(3):1242-51. Knapp JM, Wood AB, Phuan PW, Lodewyk MW, Tantillo DJ, Verkman AS, Kurth MJ. PMID: 22214395; PMCID: PMC3277286.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    53. Fluorinated ΔF508-CFTR correctors and potentiators for PET imaging. Bioorg Med Chem Lett. 2012 Feb 15; 22(4):1602-5. Davison HR, Solano DM, Phuan PW, Verkman AS, Kurth MJ. PMID: 22281185; PMCID: PMC3274619.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    54. Expedient synthesis of a 72-membered isoxazolino-β-ketoamide library by a 2·3-component reaction. ACS Comb Sci. 2012 Feb 13; 14(2):85-8. Knapp JM, Zhu JS, Wood AB, Kurth MJ. PMID: 22181856; PMCID: PMC3278521.
      View in: PubMed   Mentions: 1     Fields:    
    55. Functional fluorescently labeled bithiazole ΔF508-CFTR corrector imaged in whole body slices in mice. Bioconjug Chem. 2011 Dec 21; 22(12):2593-9. Davison HR, Taylor S, Drake C, Phuan PW, Derichs N, Yao C, Jones EF, Sutcliffe J, Verkman AS, Kurth MJ. PMID: 22034937; PMCID: PMC3245868.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    56. Influence of substituent and solvent on the radiative process of singlet excited states of novel cyclic azacyanine derivatives. J Fluoresc. 2012 Mar; 22(2):707-17. Patra D, Malaeb NN, Haddadin MJ, Kurth MJ. PMID: 22045406.
      View in: PubMed   Mentions: 2     Fields:    
    57. Quinoxalino[2,3-c]cinnolines and their 5-N-oxide: alkoxylation of methyl-substituted quinoxalino[2,3-c]cinnolines to acetals and orthoesters. J Org Chem. 2011 Oct 21; 76(20):8421-7. Haddadin MJ, El-Khatib M, Shoker TA, Beavers CM, Olmstead MM, Fettinger JC, Farber KM, Kurth MJ. PMID: 21905671.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    58. Multicomponent macrocyclization reactions (MCMRs) employing highly reactive acyl ketene and nitrile oxide intermediates. Org Lett. 2011 Sep 02; 13(17):4732-5. Knapp JM, Fettinger JC, Kurth MJ. PMID: 21827181; PMCID: PMC3162989.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    59. Electrophile-modified lipoic derivatives of PDC-E2 elicits anti-mitochondrial antibody reactivity. J Autoimmun. 2011 Nov; 37(3):209-16. Naiyanetr P, Butler JD, Meng L, Pfeiff J, Kenny TP, Guggenheim KG, Reiger R, Lam K, Kurth MJ, Ansari AA, Coppel RL, López-Hoyos M, Gershwin ME, Leung PS. PMID: 21763105; PMCID: PMC3206141.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    60. Potent, metabolically stable benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR inhibitors for polycystic kidney disease. J Med Chem. 2011 Aug 11; 54(15):5468-77. Snyder DS, Tradtrantip L, Yao C, Kurth MJ, Verkman AS. PMID: 21707078; PMCID: PMC3314378.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    61. Cyanoquinolines with independent corrector and potentiator activities restore ΔPhe508-cystic fibrosis transmembrane conductance regulator chloride channel function in cystic fibrosis. Mol Pharmacol. 2011 Oct; 80(4):683-93. Phuan PW, Yang B, Knapp JM, Wood AB, Lukacs GL, Kurth MJ, Verkman AS. PMID: 21730204; PMCID: PMC3187530.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    62. Synthesis of spiro-fused pyrazolidoylisoxazolines. J Org Chem. 2011 Jul 15; 76(14):5803-12. Guggenheim KG, Butler JD, Painter PP, Lorsbach BA, Tantillo DJ, Kurth MJ. PMID: 21650164; PMCID: PMC3132818.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    63. The Davis-Beirut reaction: N1,N2-disubstituted-1H-indazolones via 1,6-electrophilic addition to 3-alkoxy-2H-indazoles. Org Lett. 2011 Jun 17; 13(12):3138-41. Conrad WE, Fukazawa R, Haddadin MJ, Kurth MJ. PMID: 21612219; PMCID: PMC3112251.
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    64. Ethyl 1-benzyl-1,2,3,3a,4,10b-hexa-hydro-pyrrolo-[2',3':3,4]pyrrolo-[1,2-a]benzimidazole-2-carboxyl-ate. Acta Crystallogr Sect E Struct Rep Online. 2011 May 01; 67(Pt 5):o1214. Meng L, Fettinger JC, Kurth MJ. PMID: 21754512; PMCID: PMC3089295.
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    67. A rapid and efficient route to benzazole heterocycles. Nat Protoc. 2010 Nov; 5(11):1731-6. Carpenter RD, Kurth MJ. PMID: 21030949.
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    68. Orthogonally protected thiazole and isoxazole diamino acids: an efficient synthetic route. Chemistry. 2010 Aug 09; 16(30):9002-5. Butler JD, Coffman KC, Ziebart KT, Toney MD, Kurth MJ. PMID: 20623732.
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    70. Facile synthesis of glycosylated Fmoc amino acid building blocks assisted by microwave irradiation. Carbohydr Res. 2010 Oct 13; 345(15):2277-81. Yao N, Fung G, Malekan H, Ye L, Kurth MJ, Lam KS. PMID: 20832778; PMCID: PMC3207739.
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    71. Halogenated benzimidazole carboxamides target integrin alpha4beta1 on T-cell and B-cell lymphomas. Cancer Res. 2010 Jul 01; 70(13):5448-56. Carpenter RD, Natarajan A, Lau EY, Andrei M, Solano DM, Lightstone FC, Denardo SJ, Lam KS, Kurth MJ. PMID: 20530664; PMCID: PMC3166240.
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    72. Nucleophilic substitution of oxazino-/oxazolino-/benzoxazin [3,2-b]indazoles: an effective route to 1H-indazolones. Org Lett. 2010 Jun 04; 12(11):2524-7. Donald MB, Conrad WE, Oakdale JS, Butler JD, Haddadin MJ, Kurth MJ. PMID: 20438102; PMCID: PMC3108055.
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    73. Pyrazolylthiazole as DeltaF508-cystic fibrosis transmembrane conductance regulator correctors with improved hydrophilicity compared to bithiazoles. J Med Chem. 2010 May 13; 53(9):3772-81. Ye L, Knapp JM, Sangwung P, Fettinger JC, Verkman AS, Kurth MJ. PMID: 20373765; PMCID: PMC3109609.
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    74. Targeting multiple chorismate-utilizing enzymes with a single inhibitor: validation of a three-stage design. J Med Chem. 2010 May 13; 53(9):3718-29. Ziebart KT, Dixon SM, Avila B, El-Badri MH, Guggenheim KG, Kurth MJ, Toney MD. PMID: 20359225.
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    75. Isoxazolopyrimidines as Novel ΔF508-CFTR Correctors. Synlett. 2010 Apr 01; 2010(7):1063-1066. Yu GJ, Yang B, Verkman AS, Kurth MJ. PMID: 23710112; PMCID: PMC3662250.
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    77. Cyclopenta[b]pyrroles from triazines: synthetic and mechanistic studies. Org Lett. 2010 Jan 01; 12(1):164-7. Ye L, Haddadin MJ, Lodewyk MW, Ferreira AJ, Fettinger JC, Tantillo DJ, Kurth MJ. PMID: 19961148.
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    78. Design and synthesis of a hybrid potentiator-corrector agonist of the cystic fibrosis mutant protein DeltaF508-CFTR. Bioorg Med Chem Lett. 2010 Jan 01; 20(1):87-91. Mills AD, Yoo C, Butler JD, Yang B, Verkman AS, Kurth MJ. PMID: 19954980; PMCID: PMC3165007.
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    79. 3-(Arylthiomethyl)isoxazole-4,5-dicarboxamides: chemoselective nucleophilic chemistry and insecticidal activity. J Agric Food Chem. 2009 Aug 26; 57(16):7422-6. Yu GJ, Iwamoto S, Robins LI, Fettinger JC, Sparks TC, Lorsbach BA, Kurth MJ. PMID: 19624156; PMCID: PMC2847632.
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    80. Synthesis and biological activity of 2-(4,5-dihydroisoxazol-5-yl)-1,3,4-oxadiazoles. Bioorg Med Chem Lett. 2009 Oct 01; 19(19):5796-8. Milinkevich KA, Yoo CL, Sparks TC, Lorsbach BA, Kurth MJ. PMID: 19700317.
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    81. Mechanisms for formation of diazocinones, pyridazines, and pyrazolines from tetrazines--oxyanion-accelerated pericyclic cascades? J Org Chem. 2009 Jul 03; 74(13):4804-11. Lodewyk MW, Kurth MJ, Tantillo DJ. PMID: 19485385.
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    82. An oxazolo[3,2-b]indazole route to 1H-indazolones. Org Lett. 2009 Jul 02; 11(13):2760-3. Oakdale JS, Solano DM, Fettinger JC, Haddadin MJ, Kurth MJ. PMID: 19505119.
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    83. Controlling Selectivity for Cycloadditions of Nitrones and Alkenes Tethered by Benzimidazoles: Combining Experiment and Theory. European J Org Chem. 2009 Apr; 2009(10). Meng L, Wang SC, Fettinger JC, Kurth MJ, Tantillo DJ. PMID: 24327801; PMCID: PMC3856196.
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    85. Selectively targeting T- and B-cell lymphomas: a benzothiazole antagonist of alpha4beta1 integrin. J Med Chem. 2009 Jan 08; 52(1):14-9. Carpenter RD, Andrei M, Aina OH, Lau EY, Lightstone FC, Liu R, Lam KS, Kurth MJ. PMID: 19072684; PMCID: PMC3164867.
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    86. Oxidative stress caused by pyocyanin impairs CFTR Cl(-) transport in human bronchial epithelial cells. Free Radic Biol Med. 2008 Dec 15; 45(12):1653-62. Schwarzer C, Fischer H, Kim EJ, Barber KJ, Mills AD, Kurth MJ, Gruenert DC, Suh JH, Machen TE, Illek B. PMID: 18845244; PMCID: PMC2628806.
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    87. Potent s-cis-locked bithiazole correctors of DeltaF508 cystic fibrosis transmembrane conductance regulator cellular processing for cystic fibrosis therapy. J Med Chem. 2008 Oct 09; 51(19):6044-54. Yu GJ, Yoo CL, Yang B, Lodewyk MW, Meng L, El-Idreesy TT, Fettinger JC, Tantillo DJ, Verkman AS, Kurth MJ. PMID: 18788728; PMCID: PMC3167067.
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    88. Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease. Hepatology. 2008 Aug; 48(2):531-40. Wakabayashi K, Lian ZX, Leung PS, Moritoki Y, Tsuneyama K, Kurth MJ, Lam KS, Yoshida K, Yang GX, Hibi T, Ansari AA, Ridgway WM, Coppel RL, Mackay IR, Gershwin ME. PMID: 18563844; PMCID: PMC3753011.
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    89. Activation of CFTR by UCCF-029 and genistein. Bioorg Med Chem Lett. 2008 Jul 15; 18(14):3874-7. Al-Nakkash L, Springsteel MF, Kurth MJ, Nantz MH. PMID: 18595696.
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    90. Synthesis of 5-(thiazol-5-yl)-4,5-dihydroisoxazoles from 3-chloropentane-2,4-dione. J Comb Chem. 2008 Jul-Aug; 10(4):521-5. Milinkevich KA, Ye L, Kurth MJ. PMID: 18505299.
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    91. 4'-Methyl-4,5'-bithiazole-based correctors of defective delta F508-CFTR cellular processing. Bioorg Med Chem Lett. 2008 Apr 15; 18(8):2610-4. Yoo CL, Yu GJ, Yang B, Robins LI, Verkman AS, Kurth MJ. PMID: 18394886; PMCID: PMC3166558.
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    92. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell. 2008 Feb; 14(2):193-204. Cassidy-Stone A, Chipuk JE, Ingerman E, Song C, Yoo C, Kuwana T, Kurth MJ, Shaw JT, Hinshaw JE, Green DR, Nunnari J. PMID: 18267088; PMCID: PMC2267902.
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    93. Design and synthesis of propeller-shaped dispiroisoxazolinopiperidinochromanones. J Comb Chem. 2008 Mar-Apr; 10(2):225-9. Carpenter RD, DeBerdt PB, Holden JB, Milinkevich KA, Min T, Willenbring D, Fettinger JC, Tantillo DJ, Kurth MJ. PMID: 18232646.
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    94. Asymmetric catalysis: resin-bound hydroxyprolylthreonine derivatives in enamine-mediated reactions. Angew Chem Int Ed Engl. 2008; 47(34):6407-10. Carpenter RD, Fettinger JC, Lam KS, Kurth MJ. PMID: 18624312.
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    95. A facile synthesis of new 5H-indazolo[3,2-b]benzo[d]-1,3-oxazines via one-pot intramolecular Bis-heterocyclizations. J Org Chem. 2008 Jan 04; 73(1):234-40. Butler JD, Solano DM, Robins LI, Haddadin MJ, Kurth MJ. PMID: 18052193.
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    96. Intramolecular cycloaddition of azomethine ylides in the preparation of pyrrolidino[2',3':3,4]pyrrolidino[1,2- a]benzimidazoles. Org Lett. 2007 Nov 22; 9(24):5055-8. Meng L, Fettinger JC, Kurth MJ. PMID: 17973485.
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    97. Highly potent, water soluble benzimidazole antagonist for activated alpha 4 beta 1 integrin. J Med Chem. 2007 Nov 15; 50(23):5863-7. Carpenter RD, Andrei M, Lau EY, Lightstone FC, Liu R, Lam KS, Kurth MJ. PMID: 17948981.
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    98. A library of 3-aryl-4,5-dihydroisoxazole-5-carboxamides. J Comb Chem. 2007 Nov-Dec; 9(6):1041-5. Jeddeloh MR, Holden JB, Nouri DH, Kurth MJ. PMID: 17910514.
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    99. Induction of primary biliary cirrhosis in guinea pigs following chemical xenobiotic immunization. J Immunol. 2007 Aug 15; 179(4):2651-7. Leung PS, Park O, Tsuneyama K, Kurth MJ, Lam KS, Ansari AA, Coppel RL, Gershwin ME. PMID: 17675529.
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    100. 1,3,5-triazine-based mass spectral tagging of one-bead one-compound libraries. Org Lett. 2007 Jan 18; 9(2):171-3. Robins LI, Kurth MJ. PMID: 17217257.
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    101. Microwave-mediated heterocyclization to benzimidazo[2,1-b]quinazolin-12(5H)-ones. J Org Chem. 2007 Jan 05; 72(1):284-7. Carpenter RD, Lam KS, Kurth MJ. PMID: 17194113.
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    102. A spiroisoxazolinoproline-based amino acid scaffold for solid phase and one-bead-one-compound library synthesis. J Comb Chem. 2007 Jan-Feb; 9(1):143-57. Dixon SM, Milinkevich KA, Fujii J, Liu R, Yao N, Lam KS, Kurth MJ. PMID: 17206843.
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    103. Synthesis of a library of 2-alkyl-3-alkyloxy-2H-indazole-6-carboxamides. J Comb Chem. 2007 Jan-Feb; 9(1):171-7. Mills AD, Maloney P, Hassanein E, Haddadin MJ, Kurth MJ. PMID: 17206845.
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    104. Selective nucleophilic chemistry in the synthesis of 5-carbamoyl-3-sulfanylmethylisoxazole-4-carboxylic acids. J Comb Chem. 2007 Jan-Feb; 9(1):139-42. Robins LI, Fettinger JC, Tinti DS, Kurth MJ. PMID: 17206842.
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    105. Aminodeoxychorismate synthase inhibitors from one-bead one-compound combinatorial libraries: "staged" inhibitor design. J Med Chem. 2006 Dec 14; 49(25):7413-26. Dixon S, Ziebart KT, He Z, Jeddeloh M, Yoo CL, Wang X, Lehman A, Lam KS, Toney MD, Kurth MJ. PMID: 17149871.
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    106. Carbodiimide-based benzimidazole library method. J Comb Chem. 2006 Nov-Dec; 8(6):907-14. Carpenter RD, Deberdt PB, Lam KS, Kurth MJ. PMID: 17096580.
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    107. On-bead combinatorial techniques for the identification of selective aldose reductase inhibitors. Bioorg Med Chem. 2006 Dec 01; 14(23):7728-35. Robins LI, Dixon SM, Wilson DK, Kurth MJ. PMID: 16931029.
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    108. Identification of 2-nonynoic acid, a cosmetic component, as a potential trigger of primary biliary cirrhosis. J Autoimmun. 2006 Aug; 27(1):7-16. Rieger R, Leung PS, Jeddeloh MR, Kurth MJ, Nantz MH, Lam KS, Barsky D, Ansari AA, Coppel RL, Mackay IR, Gershwin ME. PMID: 16876981.
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    109. Slow-binding human serine racemase inhibitors from high-throughput screening of combinatorial libraries. J Med Chem. 2006 Apr 20; 49(8):2388-97. Dixon SM, Li P, Liu R, Wolosker H, Lam KS, Kurth MJ, Toney MD. PMID: 16610782.
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    110. N,N-bond-forming heterocyclization: synthesis of 3-alkoxy-2H-indazoles. J Org Chem. 2006 Mar 31; 71(7):2687-9. Mills AD, Nazer MZ, Haddadin MJ, Kurth MJ. PMID: 16555821.
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    111. Diazocinones: synthesis and conformational analysis. J Org Chem. 2006 Mar 17; 71(6):2480-5. Robins LI, Carpenter RD, Fettinger JC, Haddadin MJ, Tinti DS, Kurth MJ. PMID: 16526800.
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    112. Sulfamoyl-4-oxoquinoline-3-carboxamides: novel potentiators of defective DeltaF508-cystic fibrosis transmembrane conductance regulator chloride channel gating. Bioorg Med Chem Lett. 2006 Feb; 16(3):537-40. Suen YF, Robins L, Yang B, Verkman AS, Nantz MH, Kurth MJ. PMID: 16288863.
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    113. A novel route to fully substituted 1H-pyrazoles. J Org Chem. 2005 Oct 14; 70(21):8468-71. Suen YF, Hope H, Nantz MH, Haddadin MJ, Kurth MJ. PMID: 16209593.
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    114. Stannous chloride in alcohol: a one-pot conversion of 2-nitro-N-arylbenzamides to 2,3-dihydro-1H-quinazoline-4-ones. J Org Chem. 2005 Aug 19; 70(17):6941-3. Yoo CL, Fettinger JC, Kurth MJ. PMID: 16095321.
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    116. Chemical xenobiotics and mitochondrial autoantigens in primary biliary cirrhosis: identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid. J Immunol. 2005 May 01; 174(9):5874-83. Amano K, Leung PS, Rieger R, Quan C, Wang X, Marik J, Suen YF, Kurth MJ, Nantz MH, Ansari AA, Lam KS, Zeniya M, Matsuura E, Coppel RL, Gershwin ME. PMID: 15845458.
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    117. Phenylglycine and sulfonamide correctors of defective delta F508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating. Mol Pharmacol. 2005 May; 67(5):1797-807. Pedemonte N, Sonawane ND, Taddei A, Hu J, Zegarra-Moran O, Suen YF, Robins LI, Dicus CW, Willenbring D, Nantz MH, Kurth MJ, Galietta LJ, Verkman AS. PMID: 15722457.
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    118. Claimed 2,1-benzisoxazoles are indazalones. J Org Chem. 2005 Feb 04; 70(3):1060-2. Kurth MJ, Olmstead MM, Haddadin MJ. PMID: 15675871.
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    121. Solid-phase synthesis of 5-isoxazol-4-yl-[1,2,4]oxadiazoles. J Org Chem. 2004 Mar 05; 69(5):1470-4. Quan C, Kurth M. PMID: 14986998.
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    123. Autoreactivity to lipoate and a conjugated form of lipoate in primary biliary cirrhosis. Gastroenterology. 2003 Dec; 125(6):1705-13. Bruggraber SF, Leung PS, Amano K, Quan C, Kurth MJ, Nantz MH, Benson GD, Van de Water J, Luketic V, Roche TE, Ansari AA, Coppel RL, Gershwin ME. PMID: 14724823.
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    125. Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain. Bioorg Med Chem. 2003 Sep 01; 11(18):4113-20. Springsteel MF, Galietta LJ, Ma T, By K, Berger GO, Yang H, Dicus CW, Choung W, Quan C, Shelat AA, Guy RK, Verkman AS, Kurth MJ, Nantz MH. PMID: 12927873.
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    127. Immunization with a xenobiotic 6-bromohexanoate bovine serum albumin conjugate induces antimitochondrial antibodies. J Immunol. 2003 May 15; 170(10):5326-32. Leung PS, Quan C, Park O, Van de Water J, Kurth MJ, Nantz MH, Ansari AA, Coppel RL, Lam KS, Gershwin ME. PMID: 12734383.
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    128. CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds. Am J Physiol Lung Cell Mol Physiol. 2003 Jul; 285(1):L180-8. Caci E, Folli C, Zegarra-Moran O, Ma T, Springsteel MF, Sammelson RE, Nantz MH, Kurth MJ, Verkman AS, Galietta LJ. PMID: 12651632.
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    129. Oxazaborolidines as functional monomers: ketone reduction using polymer-supported Corey, Bakshi, and Shibata catalysts. J Org Chem. 2002 Nov 15; 67(23):8086-9. Price MD, Sui JK, Kurth MJ, Schore NE. PMID: 12423136.
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    133. Stereoselective synthesis of unnatural spiroisoxazolinoproline-based amino acids and derivatives. J Org Chem. 2002 Aug 09; 67(16):5673-7. Cheng WC, Liu Y, Wong M, Olmstead MM, Lam KS, Kurth MJ. PMID: 12153267.
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    134. The sulfone linker in solid-phase synthesis: preparation of 3,5-disubstituted cyclopent-2-enones. J Org Chem. 2002 Jun 28; 67(13):4387-91. Cheng WC, Kurth MJ. PMID: 12076132.
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