Mark J Kurth

Title(s)Professor Emeritus, Chemistry
SchoolUniversity of California, Davis
Address5467 Chemistry Annex
CA 95616
Phone(530)554-2145
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    1. Davis-Beirut Reaction Inspired Nitroso Diels-Alder Reaction. Tetrahedron Lett. 2021 Apr 13; 69. Son JH, Cheung A, Zhu JS, Haddadin MJ, Kurth MJ. PMID: 33854257.
      View in: PubMed   Mentions:    Fields:    
    2. 1-BENZYLSPIRO[PIPERIDINE-4,1'-PYRIDO[3,4-b]indole] 'co-potentiators' for minimal function CFTR mutants. Eur J Med Chem. 2021 Jan 01; 209:112888. Son JH, Phuan PW, Zhu JS, Lipman E, Cheung A, Tsui KY, Tantillo DJ, Verkman AS, Haggie PM, Kurth MJ. PMID: 33092904.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. A Redox Isomerization Strategy for Accessing Modular Azobenzene Photoswitches with Near Quantitative Bidirectional Photoconversion. Org Lett. 2019 11 01; 21(21):8765-8770. Zhu JS, Larach JM, Tombari RJ, Gingrich PW, Bode SR, Tuck JR, Warren HT, Son JH, Duim WC, Fettinger JC, Haddadin MJ, Tantillo DJ, Kurth MJ, Olson DE. PMID: 31638403.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    4. Davis-Beirut Reaction: A Photochemical Brønsted Acid Catalyzed Route to N-Aryl 2H-Indazoles. Org Lett. 2019 08 02; 21(15):6058-6062. Kraemer N, Li CJ, Zhu JS, Larach JM, Tsui KY, Tantillo DJ, Haddadin MJ, Kurth MJ. PMID: 31339318.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    5. Davis-Beirut Reaction: Diverse Chemistries of Highly Reactive Nitroso Intermediates in Heterocycle Synthesis. Acc Chem Res. 2019 08 20; 52(8):2256-2265. Zhu JS, Haddadin MJ, Kurth MJ. PMID: 31328502.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    6. Synthesis and evaluation of tetrahydropyrazolopyridine inhibitors of anion exchange protein SLC26A4 (pendrin). Bioorg Med Chem Lett. 2019 08 15; 29(16):2119-2123. Zhu JS, Lu JY, Tan JA, Rivera AA, Phuan PW, Shatskikh ME, Son JH, Haggie PM, Verkman AS, Kurth MJ. PMID: 31281021.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    7. Accessing Multiple Classes of 2 H-Indazoles: Mechanistic Implications for the Cadogan and Davis-Beirut Reactions. J Am Chem Soc. 2019 04 17; 141(15):6247-6253. Zhu JS, Li CJ, Tsui KY, Kraemer N, Son JH, Haddadin MJ, Tantillo DJ, Kurth MJ. PMID: 30912441.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    8. Novel 2-(5-Imino-5H-isoquinolones[3,4-b]quinoxalin-7-ylmethyl)-benzonitrile (DIQ3) and Other Related Derivatives Targeting Colon Cancer Cells: Syntheses and in Vitro Models. ACS Omega. 2019 Feb 28; 4(2):3205-3212. Monzer A, Jabotian N, Ballout F, Zhu JS, Kurth MJ, Haddadin MJ, Gali-Muhtasib H. PMID: 30842984.
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    9. Photochemical Preparation of 1,2-Dihydro-3 H-indazol-3-ones in Aqueous Solvent at Room Temperature. J Org Chem. 2018 12 21; 83(24):15493-15498. Zhu JS, Kraemer N, Li CJ, Haddadin MJ, Kurth MJ. PMID: 30468072.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    10. N-N Bond Formation between Primary Amines and Nitrosos: Direct Synthesis of 2-Substituted Indazolones with Mechanistic Insights. Org Lett. 2018 08 17; 20(16):4736-4739. Zhu JS, Kraemer N, Shatskikh ME, Li CJ, Son JH, Haddadin MJ, Tantillo DJ, Kurth MJ. PMID: 30067041.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    11. Davis-Beirut Reaction: Alkoxide versus Hydroxide Addition to the Key o-Nitrosoimine Intermediate. Org Lett. 2018 03 02; 20(5):1308-1311. Zhu JS, Duong MR, Teuthorn AP, Lu JY, Son JH, Haddadin MJ, Kurth MJ. PMID: 29431446.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    12. Correction to "Diverting Reactive Intermediates Toward Unusual Chemistry: Unexpected Anthranil Products from Davis-Beirut Reaction". J Org Chem. 2017 12 01; 82(23):12946. Zhu JS, Son JH, Teuthorn AP, Haddadin MJ, Kurth MJ, Tantillo DJ. PMID: 29091433.
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    13. Diverting Reactive Intermediates Toward Unusual Chemistry: Unexpected Anthranil Products from Davis-Beirut Reaction. J Org Chem. 2017 10 20; 82(20):10875-10882. Zhu JS, Son JH, Teuthorn AP, Haddadin MJ, Kurth MJ, Tantillo DJ. PMID: 28922917.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    14. High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators. J Med Chem. 2017 03 23; 60(6):2401-2410. Son JH, Zhu JS, Phuan PW, Cil O, Teuthorn AP, Ku CK, Lee S, Verkman AS, Kurth MJ. PMID: 28230981.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    15. One-Pot Synthesis of Benzo[4,5]imidazo[2,1-a]isoquinolines and Isoquinolino[3,4-b]quinoxalines via Tandem Cyclization Strategies. J Org Chem. 2016 05 06; 81(9):3924-8. Bagdasarian AL, Nguyen HH, Palazzo TA, Fettinger JC, Haddadin MJ, Kurth MJ. PMID: 27030441.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    16. Dibenzonaphthyridinones: Heterocycle-to-Heterocycle Synthetic Strategies and Photophysical Studies. Org Lett. 2015 Dec 04; 17(23):5732-5. Palazzo TA, Patra D, Yang JS, El Khoury E, Appleton MG, Haddadin MJ, Tantillo DJ, Kurth MJ. PMID: 26574652.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    17. Expedient one-pot synthesis of indolo[3,2-c]isoquinolines via a base-promoted N-alkylation/tandem cyclization. Tetrahedron Lett. 2015 Sep 30; 56(40):5429-5433. Nguyen HH, Fettinger JC, Haddadin MJ, Kurth MJ. PMID: 26366017.
      View in: PubMed   Mentions: 1     Fields:    
    18. Predicting hydration propensities of biologically relevant a-ketoamides. Bioorg Med Chem Lett. 2015 Oct 01; 25(19):4153-7. Wedler HB, Palazzo TA, Pemberton RP, Hamann CS, Kurth MJ, Tantillo DJ. PMID: 26306983.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    19. Heterocycle-to-Heterocycle Route to Quinoline-4-amines: Reductive Heterocyclization of 3-(2-Nitrophenyl)isoxazoles. European J Org Chem. 2014 Dec; 2014(34):7651-7657. Coffman KC, Duong V, Bagdasarian AL, Fettinger JC, Haddadin MJ, Kurth MJ. PMID: 26257574.
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    20. Inhibition of myeloperoxidase: evaluation of 2H-indazoles and 1H-indazolones. Bioorg Med Chem. 2014 Nov 15; 22(22):6422-9. Roth A, Ott S, Farber KM, Palazzo TA, Conrad WE, Haddadin MJ, Tantillo DJ, Cross CE, Eiserich JP, Kurth MJ. PMID: 25438766.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    21. Constrained bithiazoles: small molecule correctors of defective ?F508-CFTR protein trafficking. J Med Chem. 2014 Aug 14; 57(15):6729-38. Coffman KC, Nguyen HH, Phuan PW, Hudson BM, Yu GJ, Bagdasarian AL, Montgomery D, Lodewyk MW, Yang B, Yoo CL, Verkman AS, Tantillo DJ, Kurth MJ. PMID: 25061695.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    22. Davis-Beirut reaction: route to thiazolo-, thiazino-, and thiazepino-2H-indazoles. J Org Chem. 2014 Aug 01; 79(15):6939-45. Farber KM, Haddadin MJ, Kurth MJ. PMID: 25019525.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    23. Cyclic azacyanines: experimental and computational studies on spectroscopic properties and unique reactivity. J Fluoresc. 2014 Jul; 24(4):1285-96. Patra D, Palazzo TA, Malaeb NN, Haddadin MJ, Tantillo DJ, Kurth MJ. PMID: 24910112.
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    24. Facile one-pot assembly of imidazotriazolobenzodiazepines via indium(III)-catalyzed multicomponent reactions. Org Lett. 2013 Sep 06; 15(17):4492-5. Nguyen HH, Palazzo TA, Kurth MJ. PMID: 23961714.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    25. Antimitochondrial antibody recognition and structural integrity of the inner lipoyl domain of the E2 subunit of pyruvate dehydrogenase complex. J Immunol. 2013 Sep 01; 191(5):2126-33. Wang J, Budamagunta MS, Voss JC, Kurth MJ, Lam KS, Lu L, Kenny TP, Bowlus C, Kikuchi K, Coppel RL, Ansari AA, Gershwin ME, Leung PS. PMID: 23894195.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    26. ABSOLUTE CONFIGURATION AND BIOLOGICAL PROPERTIES OF ENANTIOMERS OF CFTR INHIBITOR BPO-27. ACS Med Chem Lett. 2013 May 09; 4(5):456-459. Snyder DS, Tradtrantip L, Battula S, Yao C, Phuan PW, Fettinger JC, Kurth MJ, Verkman AS. PMID: 23814642.
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    27. Heterocycle-heterocycle strategies: (2-nitrophenyl)isoxazole precursors to 4-aminoquinolines, 1H-indoles, and quinolin-4(1H)-ones. Org Lett. 2013 Apr 19; 15(8):2062-5. Coffman KC, Palazzo TA, Hartley TP, Fettinger JC, Tantillo DJ, Kurth MJ. PMID: 23557405.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    28. Antimitochondrial antibody heterogeneity and the xenobiotic etiology of primary biliary cirrhosis. Hepatology. 2013 Apr; 57(4):1498-508. Chen RC, Naiyanetr P, Shu SA, Wang J, Yang GX, Kenny TP, Guggenheim KC, Butler JD, Bowlus C, Tao MH, Kurth MJ, Ansari AA, Kaplan M, Coppel RL, Lleo A, Gershwin ME, Leung PS. PMID: 23184636.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    29. Environment and primary biliary cirrhosis: electrophilic drugs and the induction of AMA. J Autoimmun. 2013 Mar; 41:79-86. Leung PS, Wang J, Naiyanetr P, Kenny TP, Lam KS, Kurth MJ, Gershwin ME. PMID: 23352659.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    30. Microwave-assisted synthesis of 3-nitroindoles from N-aryl enamines via intramolecular arene-alkene coupling. Org Lett. 2013 Jan 18; 15(2):362-5. Nguyen HH, Kurth MJ. PMID: 23268775.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    31. Identification of inhibitors against interaction between pro-inflammatory sPLA2-IIA protein and integrin avß3. Bioorg Med Chem Lett. 2013 Jan 01; 23(1):340-5. Ye L, Dickerson T, Kaur H, Takada YK, Fujita M, Liu R, Knapp JM, Lam KS, Schore NE, Kurth MJ, Takada Y. PMID: 23164706.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    32. The Davis-Beirut Reaction: a novel entry into 2H-indazoles and indazolones. Recent biological activity of indazoles. Mini Rev Med Chem. 2012 Oct; 12(12):1293-300. Haddadin MJ, Conrad WE, Kurth MJ. PMID: 23092440.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    33. Multicomponent assembly of highly substituted indoles by dual palladium-catalyzed coupling reactions. Angew Chem Int Ed Engl. 2012 Oct 15; 51(42):10588-91. Knapp JM, Zhu JS, Tantillo DJ, Kurth MJ. PMID: 23001913.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    34. Acid and base catalyzed Davis-Beirut reaction: experimental and theoretical mechanistic studies and synthesis of novel 3-amino-2H-indazoles. Tetrahedron Lett. 2012 Nov 28; 53(48):6475-6478. Avila B, El-Dakdouki MH, Nazer MZ, Harrison JG, Tantillo DJ, Haddadin MJ, Kurth MJ. PMID: 23139435.
      View in: PubMed   Mentions: 4     Fields:    
    35. Xenobiotics and autoimmunity: does acetaminophen cause primary biliary cirrhosis? Trends Mol Med. 2012 Oct; 18(10):577-82. Leung PS, Lam K, Kurth MJ, Coppel RL, Gershwin ME. PMID: 22920894.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    36. A one-pot-three-step route to triazolotriazepinoindazolones from oxazolino-2H-indazoles. Org Lett. 2012 Aug 03; 14(15):3870-3. Conrad WE, Rodriguez KX, Nguyen HH, Fettinger JC, Haddadin MJ, Kurth MJ. PMID: 22823414.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    37. Triazolbenzo[d]thiazoles: efficient synthesis and biological evaluation as neuroprotective agents. Bioorg Med Chem Lett. 2012 Sep 15; 22(18):5976-8. Avila B, Roth A, Streets H, Dwyer DS, Kurth MJ. PMID: 22892117.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    38. Unusual Friedlander reactions: a route to novel quinoxaline-based heterocycles. Org Lett. 2012 Jul 20; 14(14):3704-7. Shoker TA, Ghattass KI, Fettinger JC, Kurth MJ, Haddadin MJ. PMID: 22783916.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    39. Click-based synthesis of triazolobithiazole ?F508-CFTR correctors for cystic fibrosis. Bioorg Med Chem. 2012 Sep 01; 20(17):5247-53. Donald MB, Rodriguez KX, Shay H, Phuan PW, Verkman AS, Kurth MJ. PMID: 22841006.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    40. 7-Substituted 8-aza-7-deazaadenosines for modification of the siRNA major groove. Org Biomol Chem. 2012 Aug 28; 10(32):6491-7. Ibarra-Soza JM, Morris AA, Jayalath P, Peacock H, Conrad WE, Donald MB, Kurth MJ, Beal PA. PMID: 22766576.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    41. One-pot, two-step cascade synthesis of quinazolinotriazolobenzodiazepines. Org Lett. 2012 Jul 20; 14(14):3732-5. Guggenheim KG, Toru H, Kurth MJ. PMID: 22746550.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    42. Isoxazolodihydropyridinones: 1,3-dipolar cycloaddition of nitrile oxides onto 2,4-dioxopiperidines. ACS Comb Sci. 2012 Apr 09; 14(4):280-4. Coffman KC, Hartley TP, Dallas JL, Kurth MJ. PMID: 22352295.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    43. Structure-activity relationships of cyanoquinolines with corrector-potentiator activity in ?F508 cystic fibrosis transmembrane conductance regulator protein. J Med Chem. 2012 Feb 09; 55(3):1242-51. Knapp JM, Wood AB, Phuan PW, Lodewyk MW, Tantillo DJ, Verkman AS, Kurth MJ. PMID: 22214395.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    44. Fluorinated ?F508-CFTR correctors and potentiators for PET imaging. Bioorg Med Chem Lett. 2012 Feb 15; 22(4):1602-5. Davison HR, Solano DM, Phuan PW, Verkman AS, Kurth MJ. PMID: 22281185.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    45. Functional fluorescently labeled bithiazole ?F508-CFTR corrector imaged in whole body slices in mice. Bioconjug Chem. 2011 Dec 21; 22(12):2593-9. Davison HR, Taylor S, Drake C, Phuan PW, Derichs N, Yao C, Jones EF, Sutcliffe J, Verkman AS, Kurth MJ. PMID: 22034937.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    46. Influence of substituent and solvent on the radiative process of singlet excited states of novel cyclic azacyanine derivatives. J Fluoresc. 2012 Mar; 22(2):707-17. Patra D, Malaeb NN, Haddadin MJ, Kurth MJ. PMID: 22045406.
      View in: PubMed   Mentions: 2     Fields:    
    47. Quinoxalino[2,3-c]cinnolines and their 5-N-oxide: alkoxylation of methyl-substituted quinoxalino[2,3-c]cinnolines to acetals and orthoesters. J Org Chem. 2011 Oct 21; 76(20):8421-7. Haddadin MJ, El-Khatib M, Shoker TA, Beavers CM, Olmstead MM, Fettinger JC, Farber KM, Kurth MJ. PMID: 21905671.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    48. Multicomponent macrocyclization reactions (MCMRs) employing highly reactive acyl ketene and nitrile oxide intermediates. Org Lett. 2011 Sep 02; 13(17):4732-5. Knapp JM, Fettinger JC, Kurth MJ. PMID: 21827181.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    49. Electrophile-modified lipoic derivatives of PDC-E2 elicits anti-mitochondrial antibody reactivity. J Autoimmun. 2011 Nov; 37(3):209-16. Naiyanetr P, Butler JD, Meng L, Pfeiff J, Kenny TP, Guggenheim KG, Reiger R, Lam K, Kurth MJ, Ansari AA, Coppel RL, López-Hoyos M, Gershwin ME, Leung PS. PMID: 21763105.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    50. Synthesis of spiro-fused pyrazolidoylisoxazolines. J Org Chem. 2011 Jul 15; 76(14):5803-12. Guggenheim KG, Butler JD, Painter PP, Lorsbach BA, Tantillo DJ, Kurth MJ. PMID: 21650164.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    51. The Davis-Beirut reaction: N1,N2-disubstituted-1H-indazolones via 1,6-electrophilic addition to 3-alkoxy-2H-indazoles. Org Lett. 2011 Jun 17; 13(12):3138-41. Conrad WE, Fukazawa R, Haddadin MJ, Kurth MJ. PMID: 21612219.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    52. Ethyl 1-benzyl-1,2,3,3a,4,10b-hexa-hydro-pyrrolo-[2',3':3,4]pyrrolo-[1,2-a]benzimidazole-2-carboxyl-ate. Acta Crystallogr Sect E Struct Rep Online. 2011 May 01; 67(Pt 5):o1214. Meng L, Fettinger JC, Kurth MJ. PMID: 21754512.
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    53. Facile syntheses of novel benzo-1,3-dioxolo-, benzothiazolo-, pyrido-, and quinolino-fused 5H-benzo[d]-pyrazolo[5,1-b][1,3]-oxazines and 1H-pyrazoles. Org Lett. 2011 Mar 04; 13(5):1060-3. Avila B, Solano DM, Haddadin MJ, Kurth MJ. PMID: 21294577.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    54. Efficient syntheses of the unknown quinolino[2,3-c]cinnolines; synthesis of neocryptolepines. Org Lett. 2010 Dec 03; 12(23):5502-5. Haddadin MJ, Bou Zerdan RM, Kurth MJ, Fettinger JC. PMID: 21067220.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    55. Orthogonally protected thiazole and isoxazole diamino acids: an efficient synthetic route. Chemistry. 2010 Aug 09; 16(30):9002-5. Butler JD, Coffman KC, Ziebart KT, Toney MD, Kurth MJ. PMID: 20623732.
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    56. Synthesis of substituted chromanones: an organocatalytic aldol/oxa-Michael reaction. Org Lett. 2010 Aug 06; 12(15):3410-3. Butler JD, Conrad WE, Lodewyk MW, Fettinger JC, Tantillo DJ, Kurth MJ. PMID: 20617821.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    57. Halogenated benzimidazole carboxamides target integrin alpha4beta1 on T-cell and B-cell lymphomas. Cancer Res. 2010 Jul 01; 70(13):5448-56. Carpenter RD, Natarajan A, Lau EY, Andrei M, Solano DM, Lightstone FC, Denardo SJ, Lam KS, Kurth MJ. PMID: 20530664.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    58. Nucleophilic substitution of oxazino-/oxazolino-/benzoxazin [3,2-b]indazoles: an effective route to 1H-indazolones. Org Lett. 2010 Jun 04; 12(11):2524-7. Donald MB, Conrad WE, Oakdale JS, Butler JD, Haddadin MJ, Kurth MJ. PMID: 20438102.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    59. Targeting multiple chorismate-utilizing enzymes with a single inhibitor: validation of a three-stage design. J Med Chem. 2010 May 13; 53(9):3718-29. Ziebart KT, Dixon SM, Avila B, El-Badri MH, Guggenheim KG, Kurth MJ, Toney MD. PMID: 20359225.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    60. Pyrazolylthiazole as DeltaF508-cystic fibrosis transmembrane conductance regulator correctors with improved hydrophilicity compared to bithiazoles. J Med Chem. 2010 May 13; 53(9):3772-81. Ye L, Knapp JM, Sangwung P, Fettinger JC, Verkman AS, Kurth MJ. PMID: 20373765.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    61. Isoxazolopyrimidines as Novel ?F508-CFTR Correctors. Synlett. 2010 Apr 01; 2010(7):1063-1066. Yu GJ, Yang B, Verkman AS, Kurth MJ. PMID: 23710112.
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    62. Parallel Synthesis of bis-heterocyclic isoxazolylmethyl- and isoxazolinylmethylpyrazoles. J Comb Chem. 2010 Jan-Feb; 12(1):129-36. Meng L, Lorsbach BA, Sparks TC, Fettinger JC, Kurth MJ. PMID: 20000375.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    63. Cyclopenta[b]pyrroles from triazines: synthetic and mechanistic studies. Org Lett. 2010 Jan 01; 12(1):164-7. Ye L, Haddadin MJ, Lodewyk MW, Ferreira AJ, Fettinger JC, Tantillo DJ, Kurth MJ. PMID: 19961148.
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    64. Design and synthesis of a hybrid potentiator-corrector agonist of the cystic fibrosis mutant protein DeltaF508-CFTR. Bioorg Med Chem Lett. 2010 Jan 01; 20(1):87-91. Mills AD, Yoo C, Butler JD, Yang B, Verkman AS, Kurth MJ. PMID: 19954980.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    65. 3-(Arylthiomethyl)isoxazole-4,5-dicarboxamides: chemoselective nucleophilic chemistry and insecticidal activity. J Agric Food Chem. 2009 Aug 26; 57(16):7422-6. Yu GJ, Iwamoto S, Robins LI, Fettinger JC, Sparks TC, Lorsbach BA, Kurth MJ. PMID: 19624156.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    66. Synthesis and biological activity of 2-(4,5-dihydroisoxazol-5-yl)-1,3,4-oxadiazoles. Bioorg Med Chem Lett. 2009 Oct 01; 19(19):5796-8. Milinkevich KA, Yoo CL, Sparks TC, Lorsbach BA, Kurth MJ. PMID: 19700317.
      View in: PubMed   Mentions: 2     Fields:    
    67. Mechanisms for formation of diazocinones, pyridazines, and pyrazolines from tetrazines--oxyanion-accelerated pericyclic cascades? J Org Chem. 2009 Jul 03; 74(13):4804-11. Lodewyk MW, Kurth MJ, Tantillo DJ. PMID: 19485385.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    68. An oxazolo[3,2-b]indazole route to 1H-indazolones. Org Lett. 2009 Jul 02; 11(13):2760-3. Oakdale JS, Solano DM, Fettinger JC, Haddadin MJ, Kurth MJ. PMID: 19505119.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    69. Controlling Selectivity for Cycloadditions of Nitrones and Alkenes Tethered by Benzimidazoles: Combining Experiment and Theory. European J Org Chem. 2009 Apr; 2009(10). Meng L, Wang SC, Fettinger JC, Kurth MJ, Tantillo DJ. PMID: 24327801.
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    70. Synthesis of thiazolo- and 7,8-dihydrothiazolo[4,5-e]benzoisoxazoles. J Comb Chem. 2009 Mar 09; 11(2):228-38. El-Badri MH, Kurth MJ. PMID: 19154120.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    71. Selectively targeting T- and B-cell lymphomas: a benzothiazole antagonist of alpha4beta1 integrin. J Med Chem. 2009 Jan 08; 52(1):14-9. Carpenter RD, Andrei M, Aina OH, Lau EY, Lightstone FC, Liu R, Lam KS, Kurth MJ. PMID: 19072684.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    72. Potent s-cis-locked bithiazole correctors of DeltaF508 cystic fibrosis transmembrane conductance regulator cellular processing for cystic fibrosis therapy. J Med Chem. 2008 Oct 09; 51(19):6044-54. Yu GJ, Yoo CL, Yang B, Lodewyk MW, Meng L, El-Idreesy TT, Fettinger JC, Tantillo DJ, Verkman AS, Kurth MJ. PMID: 18788728.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    73. Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease. Hepatology. 2008 Aug; 48(2):531-40. Wakabayashi K, Lian ZX, Leung PS, Moritoki Y, Tsuneyama K, Kurth MJ, Lam KS, Yoshida K, Yang GX, Hibi T, Ansari AA, Ridgway WM, Coppel RL, Mackay IR, Gershwin ME. PMID: 18563844.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCellsPHPublic Health
    74. Synthesis of 5-(thiazol-5-yl)-4,5-dihydroisoxazoles from 3-chloropentane-2,4-dione. J Comb Chem. 2008 Jul-Aug; 10(4):521-5. Milinkevich KA, Ye L, Kurth MJ. PMID: 18505299.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    75. 4'-Methyl-4,5'-bithiazole-based correctors of defective delta F508-CFTR cellular processing. Bioorg Med Chem Lett. 2008 Apr 15; 18(8):2610-4. Yoo CL, Yu GJ, Yang B, Robins LI, Verkman AS, Kurth MJ. PMID: 18394886.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    76. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell. 2008 Feb; 14(2):193-204. Cassidy-Stone A, Chipuk JE, Ingerman E, Song C, Yoo C, Kuwana T, Kurth MJ, Shaw JT, Hinshaw JE, Green DR, Nunnari J. PMID: 18267088.
      View in: PubMed   Mentions: 452     Fields:    Translation:HumansAnimalsCells
    77. Design and synthesis of propeller-shaped dispiroisoxazolinopiperidinochromanones. J Comb Chem. 2008 Mar-Apr; 10(2):225-9. Carpenter RD, DeBerdt PB, Holden JB, Milinkevich KA, Min T, Willenbring D, Fettinger JC, Tantillo DJ, Kurth MJ. PMID: 18232646.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    78. Asymmetric catalysis: resin-bound hydroxyprolylthreonine derivatives in enamine-mediated reactions. Angew Chem Int Ed Engl. 2008; 47(34):6407-10. Carpenter RD, Fettinger JC, Lam KS, Kurth MJ. PMID: 18624312.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    79. A facile synthesis of new 5H-indazolo[3,2-b]benzo[d]-1,3-oxazines via one-pot intramolecular Bis-heterocyclizations. J Org Chem. 2008 Jan 04; 73(1):234-40. Butler JD, Solano DM, Robins LI, Haddadin MJ, Kurth MJ. PMID: 18052193.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    80. Intramolecular cycloaddition of azomethine ylides in the preparation of pyrrolidino[2',3':3,4]pyrrolidino[1,2- a]benzimidazoles. Org Lett. 2007 Nov 22; 9(24):5055-8. Meng L, Fettinger JC, Kurth MJ. PMID: 17973485.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    81. Highly potent, water soluble benzimidazole antagonist for activated alpha 4 beta 1 integrin. J Med Chem. 2007 Nov 15; 50(23):5863-7. Carpenter RD, Andrei M, Lau EY, Lightstone FC, Liu R, Lam KS, Kurth MJ. PMID: 17948981.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    82. A library of 3-aryl-4,5-dihydroisoxazole-5-carboxamides. J Comb Chem. 2007 Nov-Dec; 9(6):1041-5. Jeddeloh MR, Holden JB, Nouri DH, Kurth MJ. PMID: 17910514.
      View in: PubMed   Mentions: 2     Fields:    
    83. Induction of primary biliary cirrhosis in guinea pigs following chemical xenobiotic immunization. J Immunol. 2007 Aug 15; 179(4):2651-7. Leung PS, Park O, Tsuneyama K, Kurth MJ, Lam KS, Ansari AA, Coppel RL, Gershwin ME. PMID: 17675529.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    84. 1,3,5-triazine-based mass spectral tagging of one-bead one-compound libraries. Org Lett. 2007 Jan 18; 9(2):171-3. Robins LI, Kurth MJ. PMID: 17217257.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    85. Microwave-mediated heterocyclization to benzimidazo[2,1-b]quinazolin-12(5H)-ones. J Org Chem. 2007 Jan 05; 72(1):284-7. Carpenter RD, Lam KS, Kurth MJ. PMID: 17194113.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    86. Synthesis of a library of 2-alkyl-3-alkyloxy-2H-indazole-6-carboxamides. J Comb Chem. 2007 Jan-Feb; 9(1):171-7. Mills AD, Maloney P, Hassanein E, Haddadin MJ, Kurth MJ. PMID: 17206845.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    87. A spiroisoxazolinoproline-based amino acid scaffold for solid phase and one-bead-one-compound library synthesis. J Comb Chem. 2007 Jan-Feb; 9(1):143-57. Dixon SM, Milinkevich KA, Fujii J, Liu R, Yao N, Lam KS, Kurth MJ. PMID: 17206843.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    88. Selective nucleophilic chemistry in the synthesis of 5-carbamoyl-3-sulfanylmethylisoxazole-4-carboxylic acids. J Comb Chem. 2007 Jan-Feb; 9(1):139-42. Robins LI, Fettinger JC, Tinti DS, Kurth MJ. PMID: 17206842.
      View in: PubMed   Mentions: 1     Fields:    
    89. Aminodeoxychorismate synthase inhibitors from one-bead one-compound combinatorial libraries: "staged" inhibitor design. J Med Chem. 2006 Dec 14; 49(25):7413-26. Dixon S, Ziebart KT, He Z, Jeddeloh M, Yoo CL, Wang X, Lehman A, Lam KS, Toney MD, Kurth MJ. PMID: 17149871.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    90. Carbodiimide-based benzimidazole library method. J Comb Chem. 2006 Nov-Dec; 8(6):907-14. Carpenter RD, Deberdt PB, Lam KS, Kurth MJ. PMID: 17096580.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    91. On-bead combinatorial techniques for the identification of selective aldose reductase inhibitors. Bioorg Med Chem. 2006 Dec 01; 14(23):7728-35. Robins LI, Dixon SM, Wilson DK, Kurth MJ. PMID: 16931029.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    92. Slow-binding human serine racemase inhibitors from high-throughput screening of combinatorial libraries. J Med Chem. 2006 Apr 20; 49(8):2388-97. Dixon SM, Li P, Liu R, Wolosker H, Lam KS, Kurth MJ, Toney MD. PMID: 16610782.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    93. N,N-bond-forming heterocyclization: synthesis of 3-alkoxy-2H-indazoles. J Org Chem. 2006 Mar 31; 71(7):2687-9. Mills AD, Nazer MZ, Haddadin MJ, Kurth MJ. PMID: 16555821.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    94. Diazocinones: synthesis and conformational analysis. J Org Chem. 2006 Mar 17; 71(6):2480-5. Robins LI, Carpenter RD, Fettinger JC, Haddadin MJ, Tinti DS, Kurth MJ. PMID: 16526800.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    95. Sulfamoyl-4-oxoquinoline-3-carboxamides: novel potentiators of defective DeltaF508-cystic fibrosis transmembrane conductance regulator chloride channel gating. Bioorg Med Chem Lett. 2006 Feb; 16(3):537-40. Suen YF, Robins L, Yang B, Verkman AS, Nantz MH, Kurth MJ. PMID: 16288863.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    96. A novel route to fully substituted 1H-pyrazoles. J Org Chem. 2005 Oct 14; 70(21):8468-71. Suen YF, Hope H, Nantz MH, Haddadin MJ, Kurth MJ. PMID: 16209593.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    97. Stannous chloride in alcohol: a one-pot conversion of 2-nitro-N-arylbenzamides to 2,3-dihydro-1H-quinazoline-4-ones. J Org Chem. 2005 Aug 19; 70(17):6941-3. Yoo CL, Fettinger JC, Kurth MJ. PMID: 16095321.
      View in: PubMed   Mentions: 5     Fields:    
    98. Discovery of selective aldo-keto reductase ligands--an on-bead assay strategy. Bioorg Med Chem Lett. 2005 Jun 02; 15(11):2938-42. Dixon S, Robins L, Elling RA, Liu R, Lam KS, Wilson DK, Kurth MJ. PMID: 15911284.
      View in: PubMed   Mentions:    Fields:    
    99. Chemical xenobiotics and mitochondrial autoantigens in primary biliary cirrhosis: identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid. J Immunol. 2005 May 01; 174(9):5874-83. Amano K, Leung PS, Rieger R, Quan C, Wang X, Marik J, Suen YF, Kurth MJ, Nantz MH, Ansari AA, Lam KS, Zeniya M, Matsuura E, Coppel RL, Gershwin ME. PMID: 15845458.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCellsPHPublic Health
    100. Claimed 2,1-benzisoxazoles are indazalones. J Org Chem. 2005 Feb 04; 70(3):1060-2. Kurth MJ, Olmstead MM, Haddadin MJ. PMID: 15675871.
      View in: PubMed   Mentions: 8     Fields:    
    101. OBOC small-molecule combinatorial library encoded by halogenated mass-tags. Org Lett. 2004 Oct 14; 6(21):3829-32. Hwang SH, Lehman A, Cong X, Olmstead MM, Lam KS, Lebrilla CB, Kurth MJ. PMID: 15469360.
      View in: PubMed   Mentions: 2     Fields:    
    102. Xenobiotic-induced loss of tolerance in rabbits to the mitochondrial autoantigen of primary biliary cirrhosis is reversible. J Immunol. 2004 May 15; 172(10):6444-52. Amano K, Leung PS, Xu Q, Marik J, Quan C, Kurth MJ, Nantz MH, Ansari AA, Lam KS, Zeniya M, Coppel RL, Gershwin ME. PMID: 15128836.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    103. Solid-phase synthesis of an isoxazolinopyrrole library. J Comb Chem. 2004 Jan-Feb; 6(1):142-8. Hwang SH, Olmstead MM, Kurth MJ. PMID: 14714998.
      View in: PubMed   Mentions:    Fields:    
    104. Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium. Hepatology. 2003 Nov; 38(5):1250-7. Selmi C, Balkwill DL, Invernizzi P, Ansari AA, Coppel RL, Podda M, Leung PS, Kenny TP, Van De Water J, Nantz MH, Kurth MJ, Gershwin ME. PMID: 14578864.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    105. Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain. Bioorg Med Chem. 2003 Sep 01; 11(18):4113-20. Springsteel MF, Galietta LJ, Ma T, By K, Berger GO, Yang H, Dicus CW, Choung W, Quan C, Shelat AA, Guy RK, Verkman AS, Kurth MJ, Nantz MH. PMID: 12927873.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    106. 3-(2-Benzyloxyphenyl)isoxazoles and isoxazolines: synthesis and evaluation as CFTR activators. Bioorg Med Chem Lett. 2003 Aug 04; 13(15):2509-12. Sammelson RE, Ma T, Galietta LJ, Verkman AS, Kurth MJ. PMID: 12852954.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    107. Immunization with a xenobiotic 6-bromohexanoate bovine serum albumin conjugate induces antimitochondrial antibodies. J Immunol. 2003 May 15; 170(10):5326-32. Leung PS, Quan C, Park O, Van de Water J, Kurth MJ, Nantz MH, Ansari AA, Coppel RL, Lam KS, Gershwin ME. PMID: 12734383.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    108. Oxazaborolidines as functional monomers: ketone reduction using polymer-supported Corey, Bakshi, and Shibata catalysts. J Org Chem. 2002 Nov 15; 67(23):8086-9. Price MD, Sui JK, Kurth MJ, Schore NE. PMID: 12423136.
      View in: PubMed   Mentions:    Fields:    
    109. Comparison of solid-phase and solution-phase chiral auxiliaries in the alkylation/iodolactonization sequence to gamma-butyrolactones. J Org Chem. 2002 Nov 01; 67(22):7769-73. Price MD, Kurth MJ, Schore NE. PMID: 12398501.
      View in: PubMed   Mentions: 2     Fields:    
    110. Versatile "traceless" sulfone linker for SPOS: preparation of isoxazolinopyrrole 2-carboxylates. J Org Chem. 2002 Sep 06; 67(18):6564-7. Hwang SH, Kurth MJ. PMID: 12201785.
      View in: PubMed   Mentions: 2     Fields:    
    111. Stereoselective synthesis of unnatural spiroisoxazolinoproline-based amino acids and derivatives. J Org Chem. 2002 Aug 09; 67(16):5673-7. Cheng WC, Liu Y, Wong M, Olmstead MM, Lam KS, Kurth MJ. PMID: 12153267.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    112. The sulfone linker in solid-phase synthesis: preparation of 3,5-disubstituted cyclopent-2-enones. J Org Chem. 2002 Jun 28; 67(13):4387-91. Cheng WC, Kurth MJ. PMID: 12076132.
      View in: PubMed   Mentions:    Fields:    
    113. Ipso substitution as a route to benzo[c]quinolizines and 4-hydroxycoumarins. J Org Chem. 2002 Apr 05; 67(7):2082-6. Liu Y, Kurth MJ. PMID: 11925212.
      View in: PubMed   Mentions: 1     Fields:    
    114. Imidazopyridinium and pyridopyrimidium bromides: synthesis and hydrolysis. J Org Chem. 2002 Apr 05; 67(7):2382-5. Huang KS, Haddadin MJ, Kurth MJ. PMID: 11925262.
      View in: PubMed   Mentions:    Fields:    
    115. Solid-phase synthesis of novel isoxazolocyclobutanones and isoxazolinocyclobutenones. Org Lett. 2002 Mar 07; 4(5):741-4. Cheng WC, Wong M, Olmstead MM, Kurth MJ. PMID: 11869116.
      View in: PubMed   Mentions: 2     Fields:    
    116. Synthesis of spiro-fused (C5)-isoxazolino-(C4)-pyrazolones (1-oxa-2,7,8-triazaspiro[4,4]-2,8-dien-6-ones) via 1,3-dipolar cycloaddition and cycloelimination. J Org Chem. 2002 Feb 08; 67(3):876-82. Sammelson RE, Gurusinghe CD, Kurth JM, Olmstead MM, Kurth MJ. PMID: 11856032.
      View in: PubMed   Mentions:    Fields:    
    117. 1,2,4,5-Tetrazines as oxidant and reactant with DBU: An unexpected formation of a novel fused tetraheterocyclic azepine J Org Chem. 2000 Dec 29; 65(26):9265-7. Sammelson RE, Olmstead MM, Haddadin MJ, Kurth MJ. PMID: 11149886.
      View in: PubMed   Mentions:    Fields:    
    118. Carbonminus signCarbon Bond Forming Solid-Phase Reactions. Chem Rev. 1999 Jun 09; 99(6):1549-1582. Lorsbach BA, Kurth MJ. PMID: 11849002.
      View in: PubMed   Mentions: 7     Fields:    
    119. Functionalized Cross-Linked Copolymers: A "C2 -Symmetric" Solid-Phase Catalyst for Enantioselective Reactions. Angew Chem Int Ed Engl. 1998 Mar 02; 37(4):510-512. Halm C, Kurth MJ. PMID: 29711160.
      View in: PubMed   Mentions:    Fields:    
    120. Diastereoselective Synthesis of Cyclopentanoids with Hydantoin and Isoxazoline Substituents. J Org Chem. 1998 Jan 09; 63(1):113-117. Park KH, Olmstead MM, Kurth MJ. PMID: 11674050.
      View in: PubMed   Mentions: 1     Fields:    
    121. Reissert-Based "Traceless" Solid-Phase Synthesis: Isoquinoline, and Isoxazoline-Containing Heterocycles. J Org Chem. 1996 Dec 13; 61(25):8716-8717. Lorsbach BA, Miller RB, Kurth MJ. PMID: 11667837.
      View in: PubMed   Mentions: 4     Fields:    
    122. Solid-Phase Combinatorial Synthesis of Polyisoxazolines: A Two-Reaction Iterative Protocol. J Org Chem. 1996 Dec 13; 61(25):8755-8761. Kurth MJ, Ahlberg Randall LA, Takenouchi K. PMID: 11667849.
      View in: PubMed   Mentions: 5     Fields:    
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