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Mark Kurth

TitlePROF-AY
InstitutionUniversity of California Davis
DepartmentChemistry
Address5467 Chemistry Annex
CA 95616
Phone(530)554-2145
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhu JS, Kraemer N, Shatskikh ME, Li CJ, Son JH, Haddadin MJ, Tantillo DJ, Kurth M. N-N Bond Formation between Primary Amines and Nitrosos: Direct Synthesis of 2-Substituted Indazolones with Mechanistic Insights. Org Lett. 2018 Aug 01. PMID: 30067041.
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    2. Zhu JS, Duong MR, Teuthorn AP, Lu JY, Son JH, Haddadin MJ, Kurth M. Davis-Beirut Reaction: Alkoxide versus Hydroxide Addition to the Key o-Nitrosoimine Intermediate. Org Lett. 2018 Mar 02; 20(5):1308-1311. PMID: 29431446.
      View in: PubMed
    3. Zhu JS, Son JH, Teuthorn AP, Haddadin MJ, Kurth M, Tantillo DJ. Correction to "Diverting Reactive Intermediates Toward Unusual Chemistry: Unexpected Anthranil Products from Davis-Beirut Reaction". J Org Chem. 2017 Dec 01; 82(23):12946. PMID: 29091433.
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    4. Zhu JS, Son JH, Teuthorn AP, Haddadin MJ, Kurth M, Tantillo DJ. Diverting Reactive Intermediates Toward Unusual Chemistry: Unexpected Anthranil Products from Davis-Beirut Reaction. J Org Chem. 2017 Oct 20; 82(20):10875-10882. PMID: 28922917.
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    5. Son JH, Zhu JS, Phuan PW, Cil O, Teuthorn AP, Ku CK, Lee S, Verkman AS, Kurth M. High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators. J Med Chem. 2017 Mar 23; 60(6):2401-2410. PMID: 28230981.
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    6. Bagdasarian AL, Nguyen HH, Palazzo TA, Fettinger JC, Haddadin MJ, Kurth M. One-Pot Synthesis of Benzo[4,5]imidazo[2,1-a]isoquinolines and Isoquinolino[3,4-b]quinoxalines via Tandem Cyclization Strategies. J Org Chem. 2016 05 06; 81(9):3924-8. PMID: 27030441.
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    7. Palazzo TA, Patra D, Yang JS, El Khoury E, Appleton MG, Haddadin MJ, Tantillo DJ, Kurth M. Dibenzonaphthyridinones: Heterocycle-to-Heterocycle Synthetic Strategies and Photophysical Studies. Org Lett. 2015 Dec 04; 17(23):5732-5. PMID: 26574652; PMCID: PMC4816217 [Available on 12/04/16].
    8. Nguyen HH, Fettinger JC, Haddadin MJ, Kurth M. Expedient one-pot synthesis of indolo[3,2-c]isoquinolines via a base-promoted N-alkylation/tandem cyclization. Tetrahedron Lett. 2015 Sep 30; 56(40):5429-5433. PMID: 26366017.
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    9. Wedler HB, Palazzo TA, Pemberton RP, Hamann CS, Kurth M, Tantillo DJ. Predicting hydration propensities of biologically relevant a-ketoamides. Bioorg Med Chem Lett. 2015 Oct 01; 25(19):4153-7. PMID: 26306983.
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    10. Coffman KC, Duong V, Bagdasarian AL, Fettinger JC, Haddadin MJ, Kurth M. Heterocycle-to-Heterocycle Route to Quinoline-4-amines: Reductive Heterocyclization of 3-(2-Nitrophenyl)isoxazoles. European J Org Chem. 2014 Dec; 2014(34):7651-7657. PMID: 26257574.
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    11. Roth A, Ott S, Farber KM, Palazzo TA, Conrad WE, Haddadin MJ, Tantillo DJ, Cross CE, Eiserich JP, Kurth M. Inhibition of myeloperoxidase: evaluation of 2H-indazoles and 1H-indazolones. Bioorg Med Chem. 2014 Nov 15; 22(22):6422-9. PMID: 25438766; PMCID: PMC4254468.
    12. Coffman KC, Nguyen HH, Phuan PW, Hudson BM, Yu GJ, Bagdasarian AL, Montgomery D, Lodewyk MW, Yang B, Yoo CL, Verkman AS, Tantillo DJ, Kurth M. Constrained bithiazoles: small molecule correctors of defective ?F508-CFTR protein trafficking. J Med Chem. 2014 Aug 14; 57(15):6729-38. PMID: 25061695; PMCID: PMC4136667.
    13. Farber KM, Haddadin MJ, Kurth M. Davis-Beirut reaction: route to thiazolo-, thiazino-, and thiazepino-2H-indazoles. J Org Chem. 2014 Aug 01; 79(15):6939-45. PMID: 25019525; PMCID: PMC4120971.
    14. Patra D, Palazzo TA, Malaeb NN, Haddadin MJ, Tantillo DJ, Kurth M. Cyclic azacyanines: experimental and computational studies on spectroscopic properties and unique reactivity. J Fluoresc. 2014 Jul; 24(4):1285-96. PMID: 24910112.
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    15. Nguyen HH, Palazzo TA, Kurth M. Facile one-pot assembly of imidazotriazolobenzodiazepines via indium(III)-catalyzed multicomponent reactions. Org Lett. 2013 Sep 06; 15(17):4492-5. PMID: 23961714; PMCID: PMC3850773.
    16. Wang J, Budamagunta MS, Voss JC, Kurth M, Lam KS, Lu L, Kenny TP, Bowlus C, Kikuchi K, Coppel RL, Ansari AA, Gershwin ME, Leung PS. Antimitochondrial antibody recognition and structural integrity of the inner lipoyl domain of the E2 subunit of pyruvate dehydrogenase complex. J Immunol. 2013 Sep 01; 191(5):2126-33. PMID: 23894195; PMCID: PMC3759514.
    17. Snyder DS, Tradtrantip L, Battula S, Yao C, Phuan PW, Fettinger JC, Kurth M, Verkman AS. ABSOLUTE CONFIGURATION AND BIOLOGICAL PROPERTIES OF ENANTIOMERS OF CFTR INHIBITOR BPO-27. ACS Med Chem Lett. 2013 May 09; 4(5):456-459. PMID: 23814642.
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    18. Coffman KC, Palazzo TA, Hartley TP, Fettinger JC, Tantillo DJ, Kurth M. Heterocycle-heterocycle strategies: (2-nitrophenyl)isoxazole precursors to 4-aminoquinolines, 1H-indoles, and quinolin-4(1H)-ones. Org Lett. 2013 Apr 19; 15(8):2062-5. PMID: 23557405; PMCID: PMC3643507.
    19. Chen RC, Naiyanetr P, Shu SA, Wang J, Yang GX, Kenny TP, Guggenheim KC, Butler JD, Bowlus C, Tao MH, Kurth M, Ansari AA, Kaplan M, Coppel RL, Lleo A, Gershwin ME, Leung PS. Antimitochondrial antibody heterogeneity and the xenobiotic etiology of primary biliary cirrhosis. Hepatology. 2013 Apr; 57(4):1498-508. PMID: 23184636; PMCID: PMC3601563.
    20. Leung PS, Wang J, Naiyanetr P, Kenny TP, Lam KS, Kurth M, Gershwin ME. Environment and primary biliary cirrhosis: electrophilic drugs and the induction of AMA. J Autoimmun. 2013 Mar; 41:79-86. PMID: 23352659; PMCID: PMC3622763.
    21. Nguyen HH, Kurth M. Microwave-assisted synthesis of 3-nitroindoles from N-aryl enamines via intramolecular arene-alkene coupling. Org Lett. 2013 Jan 18; 15(2):362-5. PMID: 23268775; PMCID: PMC3549302.
    22. Ye L, Dickerson T, Kaur H, Takada YK, Fujita M, Liu R, Knapp JM, Lam KS, Schore NE, Kurth M, Takada Y. Identification of inhibitors against interaction between pro-inflammatory sPLA2-IIA protein and integrin avß3. Bioorg Med Chem Lett. 2013 Jan 01; 23(1):340-5. PMID: 23164706; PMCID: PMC4570851.
    23. Haddadin MJ, Conrad WE, Kurth M. The Davis-Beirut Reaction: a novel entry into 2H-indazoles and indazolones. Recent biological activity of indazoles. Mini Rev Med Chem. 2012 Oct; 12(12):1293-300. PMID: 23092440.
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    24. Knapp JM, Zhu JS, Tantillo DJ, Kurth M. Multicomponent assembly of highly substituted indoles by dual palladium-catalyzed coupling reactions. Angew Chem Int Ed Engl. 2012 Oct 15; 51(42):10588-91. PMID: 23001913; PMCID: PMC3517165.
    25. Avila B, El-Dakdouki MH, Nazer MZ, Harrison JG, Tantillo DJ, Haddadin MJ, Kurth M. Acid and base catalyzed Davis-Beirut reaction: experimental and theoretical mechanistic studies and synthesis of novel 3-amino-2H-indazoles. Tetrahedron Lett. 2012 Nov 28; 53(48):6475-6478. PMID: 23139435.
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    26. Leung PS, Lam K, Kurth M, Coppel RL, Gershwin ME. Xenobiotics and autoimmunity: does acetaminophen cause primary biliary cirrhosis? Trends Mol Med. 2012 Oct; 18(10):577-82. PMID: 22920894; PMCID: PMC3465509.
    27. Conrad WE, Rodriguez KX, Nguyen HH, Fettinger JC, Haddadin MJ, Kurth M. A one-pot-three-step route to triazolotriazepinoindazolones from oxazolino-2H-indazoles. Org Lett. 2012 Aug 03; 14(15):3870-3. PMID: 22823414; PMCID: PMC3427757.
    28. Avila B, Roth A, Streets H, Dwyer DS, Kurth M. Triazolbenzo[d]thiazoles: efficient synthesis and biological evaluation as neuroprotective agents. Bioorg Med Chem Lett. 2012 Sep 15; 22(18):5976-8. PMID: 22892117; PMCID: PMC3432163.
    29. Shoker TA, Ghattass KI, Fettinger JC, Kurth M, Haddadin MJ. Unusual Friedlander reactions: a route to novel quinoxaline-based heterocycles. Org Lett. 2012 Jul 20; 14(14):3704-7. PMID: 22783916; PMCID: PMC3492540.
    30. Donald MB, Rodriguez KX, Shay H, Phuan PW, Verkman AS, Kurth M. Click-based synthesis of triazolobithiazole ?F508-CFTR correctors for cystic fibrosis. Bioorg Med Chem. 2012 Sep 01; 20(17):5247-53. PMID: 22841006; PMCID: PMC3419814.
    31. Ibarra-Soza JM, Morris AA, Jayalath P, Peacock H, Conrad WE, Donald MB, Kurth M, Beal PA. 7-Substituted 8-aza-7-deazaadenosines for modification of the siRNA major groove. Org Biomol Chem. 2012 Aug 28; 10(32):6491-7. PMID: 22766576; PMCID: PMC3417767.
    32. Guggenheim KG, Toru H, Kurth M. One-pot, two-step cascade synthesis of quinazolinotriazolobenzodiazepines. Org Lett. 2012 Jul 20; 14(14):3732-5. PMID: 22746550; PMCID: PMC3486955.
    33. Coffman KC, Hartley TP, Dallas JL, Kurth M. Isoxazolodihydropyridinones: 1,3-dipolar cycloaddition of nitrile oxides onto 2,4-dioxopiperidines. ACS Comb Sci. 2012 Apr 09; 14(4):280-4. PMID: 22352295; PMCID: PMC3345193.
    34. Knapp JM, Wood AB, Phuan PW, Lodewyk MW, Tantillo DJ, Verkman AS, Kurth M. Structure-activity relationships of cyanoquinolines with corrector-potentiator activity in ?F508 cystic fibrosis transmembrane conductance regulator protein. J Med Chem. 2012 Feb 09; 55(3):1242-51. PMID: 22214395; PMCID: PMC3277286.
    35. Davison HR, Solano DM, Phuan PW, Verkman AS, Kurth M. Fluorinated ?F508-CFTR correctors and potentiators for PET imaging. Bioorg Med Chem Lett. 2012 Feb 15; 22(4):1602-5. PMID: 22281185; PMCID: PMC3274619.
    36. Davison HR, Taylor S, Drake C, Phuan PW, Derichs N, Yao C, Jones EF, Sutcliffe J, Verkman AS, Kurth M. Functional fluorescently labeled bithiazole ?F508-CFTR corrector imaged in whole body slices in mice. Bioconjug Chem. 2011 Dec 21; 22(12):2593-9. PMID: 22034937; PMCID: PMC3245868.
    37. Patra D, Malaeb NN, Haddadin MJ, Kurth M. Influence of substituent and solvent on the radiative process of singlet excited states of novel cyclic azacyanine derivatives. J Fluoresc. 2012 Mar; 22(2):707-17. PMID: 22045406.
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    38. Haddadin MJ, El-Khatib M, Shoker TA, Beavers CM, Olmstead MM, Fettinger JC, Farber KM, Kurth M. Quinoxalino[2,3-c]cinnolines and their 5-N-oxide: alkoxylation of methyl-substituted quinoxalino[2,3-c]cinnolines to acetals and orthoesters. J Org Chem. 2011 Oct 21; 76(20):8421-7. PMID: 21905671.
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    39. Knapp JM, Fettinger JC, Kurth M. Multicomponent macrocyclization reactions (MCMRs) employing highly reactive acyl ketene and nitrile oxide intermediates. Org Lett. 2011 Sep 02; 13(17):4732-5. PMID: 21827181; PMCID: PMC3162989.
    40. Naiyanetr P, Butler JD, Meng L, Pfeiff J, Kenny TP, Guggenheim KG, Reiger R, Lam K, Kurth M, Ansari AA, Coppel RL, López-Hoyos M, Gershwin ME, Leung PS. Electrophile-modified lipoic derivatives of PDC-E2 elicits anti-mitochondrial antibody reactivity. J Autoimmun. 2011 Nov; 37(3):209-16. PMID: 21763105; PMCID: PMC3206141.
    41. Guggenheim KG, Butler JD, Painter PP, Lorsbach BA, Tantillo DJ, Kurth M. Synthesis of spiro-fused pyrazolidoylisoxazolines. J Org Chem. 2011 Jul 15; 76(14):5803-12. PMID: 21650164; PMCID: PMC3132818.
    42. Conrad WE, Fukazawa R, Haddadin MJ, Kurth M. The Davis-Beirut reaction: N1,N2-disubstituted-1H-indazolones via 1,6-electrophilic addition to 3-alkoxy-2H-indazoles. Org Lett. 2011 Jun 17; 13(12):3138-41. PMID: 21612219; PMCID: PMC3112251.
    43. Meng L, Fettinger JC, Kurth M. Ethyl 1-benzyl-1,2,3,3a,4,10b-hexa-hydro-pyrrolo-[2',3':3,4]pyrrolo-[1,2-a]benzimidazole-2-carboxyl-ate. Acta Crystallogr Sect E Struct Rep Online. 2011 May 01; 67(Pt 5):o1214. PMID: 21754512; PMCID: PMC3089295.
    44. Avila B, Solano DM, Haddadin MJ, Kurth M. Facile syntheses of novel benzo-1,3-dioxolo-, benzothiazolo-, pyrido-, and quinolino-fused 5H-benzo[d]-pyrazolo[5,1-b][1,3]-oxazines and 1H-pyrazoles. Org Lett. 2011 Mar 04; 13(5):1060-3. PMID: 21294577; PMCID: PMC3164999.
    45. Haddadin MJ, Bou Zerdan RM, Kurth M, Fettinger JC. Efficient syntheses of the unknown quinolino[2,3-c]cinnolines; synthesis of neocryptolepines. Org Lett. 2010 Dec 03; 12(23):5502-5. PMID: 21067220.
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    46. Butler JD, Coffman KC, Ziebart KT, Toney MD, Kurth M. Orthogonally protected thiazole and isoxazole diamino acids: an efficient synthetic route. Chemistry. 2010 Aug 09; 16(30):9002-5. PMID: 20623732.
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    47. Butler JD, Conrad WE, Lodewyk MW, Fettinger JC, Tantillo DJ, Kurth M. Synthesis of substituted chromanones: an organocatalytic aldol/oxa-Michael reaction. Org Lett. 2010 Aug 06; 12(15):3410-3. PMID: 20617821; PMCID: PMC3164863.
    48. Carpenter RD, Natarajan A, Lau EY, Andrei M, Solano DM, Lightstone FC, Denardo SJ, Lam KS, Kurth M. Halogenated benzimidazole carboxamides target integrin alpha4beta1 on T-cell and B-cell lymphomas. Cancer Res. 2010 Jul 01; 70(13):5448-56. PMID: 20530664; PMCID: PMC3166240.
    49. Donald MB, Conrad WE, Oakdale JS, Butler JD, Haddadin MJ, Kurth M. Nucleophilic substitution of oxazino-/oxazolino-/benzoxazin [3,2-b]indazoles: an effective route to 1H-indazolones. Org Lett. 2010 Jun 04; 12(11):2524-7. PMID: 20438102; PMCID: PMC3108055.
    50. Ziebart KT, Dixon SM, Avila B, El-Badri MH, Guggenheim KG, Kurth M, Toney MD. Targeting multiple chorismate-utilizing enzymes with a single inhibitor: validation of a three-stage design. J Med Chem. 2010 May 13; 53(9):3718-29. PMID: 20359225.
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    51. Ye L, Knapp JM, Sangwung P, Fettinger JC, Verkman AS, Kurth M. Pyrazolylthiazole as DeltaF508-cystic fibrosis transmembrane conductance regulator correctors with improved hydrophilicity compared to bithiazoles. J Med Chem. 2010 May 13; 53(9):3772-81. PMID: 20373765; PMCID: PMC3109609.
    52. Yu GJ, Yang B, Verkman AS, Kurth M. Isoxazolopyrimidines as Novel ?F508-CFTR Correctors. Synlett. 2010 Apr 01; 2010(7):1063-1066. PMID: 23710112.
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    53. Meng L, Lorsbach BA, Sparks TC, Fettinger JC, Kurth M. Parallel Synthesis of bis-heterocyclic isoxazolylmethyl- and isoxazolinylmethylpyrazoles. J Comb Chem. 2010 Jan-Feb; 12(1):129-36. PMID: 20000375.
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    54. Ye L, Haddadin MJ, Lodewyk MW, Ferreira AJ, Fettinger JC, Tantillo DJ, Kurth M. Cyclopenta[b]pyrroles from triazines: synthetic and mechanistic studies. Org Lett. 2010 Jan 01; 12(1):164-7. PMID: 19961148.
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    55. Mills AD, Yoo C, Butler JD, Yang B, Verkman AS, Kurth M. Design and synthesis of a hybrid potentiator-corrector agonist of the cystic fibrosis mutant protein DeltaF508-CFTR. Bioorg Med Chem Lett. 2010 Jan 01; 20(1):87-91. PMID: 19954980; PMCID: PMC3165007.
    56. Yu GJ, Iwamoto S, Robins LI, Fettinger JC, Sparks TC, Lorsbach BA, Kurth M. 3-(Arylthiomethyl)isoxazole-4,5-dicarboxamides: chemoselective nucleophilic chemistry and insecticidal activity. J Agric Food Chem. 2009 Aug 26; 57(16):7422-6. PMID: 19624156; PMCID: PMC2847632.
    57. Milinkevich KA, Yoo CL, Sparks TC, Lorsbach BA, Kurth M. Synthesis and biological activity of 2-(4,5-dihydroisoxazol-5-yl)-1,3,4-oxadiazoles. Bioorg Med Chem Lett. 2009 Oct 01; 19(19):5796-8. PMID: 19700317.
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    58. Lodewyk MW, Kurth M, Tantillo DJ. Mechanisms for formation of diazocinones, pyridazines, and pyrazolines from tetrazines--oxyanion-accelerated pericyclic cascades? J Org Chem. 2009 Jul 03; 74(13):4804-11. PMID: 19485385.
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    59. Oakdale JS, Solano DM, Fettinger JC, Haddadin MJ, Kurth M. An oxazolo[3,2-b]indazole route to 1H-indazolones. Org Lett. 2009 Jul 02; 11(13):2760-3. PMID: 19505119.
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    60. Meng L, Wang SC, Fettinger JC, Kurth M, Tantillo DJ. Controlling Selectivity for Cycloadditions of Nitrones and Alkenes Tethered by Benzimidazoles: Combining Experiment and Theory. European J Org Chem. 2009 Apr; 2009(10). PMID: 24327801.
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    61. El-Badri MH, Kurth M. Synthesis of thiazolo- and 7,8-dihydrothiazolo[4,5-e]benzoisoxazoles. J Comb Chem. 2009 Mar 09; 11(2):228-38. PMID: 19154120; PMCID: PMC3164862.
    62. Carpenter RD, Andrei M, Aina OH, Lau EY, Lightstone FC, Liu R, Lam KS, Kurth M. Selectively targeting T- and B-cell lymphomas: a benzothiazole antagonist of alpha4beta1 integrin. J Med Chem. 2009 Jan 08; 52(1):14-9. PMID: 19072684; PMCID: PMC3164867.
    63. Yu GJ, Yoo CL, Yang B, Lodewyk MW, Meng L, El-Idreesy TT, Fettinger JC, Tantillo DJ, Verkman AS, Kurth M. Potent s-cis-locked bithiazole correctors of DeltaF508 cystic fibrosis transmembrane conductance regulator cellular processing for cystic fibrosis therapy. J Med Chem. 2008 Oct 09; 51(19):6044-54. PMID: 18788728; PMCID: PMC3167067.
    64. Wakabayashi K, Lian ZX, Leung PS, Moritoki Y, Tsuneyama K, Kurth M, Lam KS, Yoshida K, Yang GX, Hibi T, Ansari AA, Ridgway WM, Coppel RL, Mackay IR, Gershwin ME. Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease. Hepatology. 2008 Aug; 48(2):531-40. PMID: 18563844; PMCID: PMC3753011.
    65. Milinkevich KA, Ye L, Kurth M. Synthesis of 5-(thiazol-5-yl)-4,5-dihydroisoxazoles from 3-chloropentane-2,4-dione. J Comb Chem. 2008 Jul-Aug; 10(4):521-5. PMID: 18505299.
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    66. Yoo CL, Yu GJ, Yang B, Robins LI, Verkman AS, Kurth M. 4'-Methyl-4,5'-bithiazole-based correctors of defective delta F508-CFTR cellular processing. Bioorg Med Chem Lett. 2008 Apr 15; 18(8):2610-4. PMID: 18394886; PMCID: PMC3166558.
    67. Cassidy-Stone A, Chipuk JE, Ingerman E, Song C, Yoo C, Kuwana T, Kurth M, Shaw JT, Hinshaw JE, Green DR, Nunnari J. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell. 2008 Feb; 14(2):193-204. PMID: 18267088; PMCID: PMC2267902.
    68. Carpenter RD, DeBerdt PB, Holden JB, Milinkevich KA, Min T, Willenbring D, Fettinger JC, Tantillo DJ, Kurth M. Design and synthesis of propeller-shaped dispiroisoxazolinopiperidinochromanones. J Comb Chem. 2008 Mar-Apr; 10(2):225-9. PMID: 18232646.
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    69. Carpenter RD, Fettinger JC, Lam KS, Kurth M. Asymmetric catalysis: resin-bound hydroxyprolylthreonine derivatives in enamine-mediated reactions. Angew Chem Int Ed Engl. 2008; 47(34):6407-10. PMID: 18624312.
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    70. Butler JD, Solano DM, Robins LI, Haddadin MJ, Kurth M. A facile synthesis of new 5H-indazolo[3,2-b]benzo[d]-1,3-oxazines via one-pot intramolecular Bis-heterocyclizations. J Org Chem. 2008 Jan 04; 73(1):234-40. PMID: 18052193.
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    71. Meng L, Fettinger JC, Kurth M. Intramolecular cycloaddition of azomethine ylides in the preparation of pyrrolidino[2',3':3,4]pyrrolidino[1,2- a]benzimidazoles. Org Lett. 2007 Nov 22; 9(24):5055-8. PMID: 17973485.
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    72. Carpenter RD, Andrei M, Lau EY, Lightstone FC, Liu R, Lam KS, Kurth M. Highly potent, water soluble benzimidazole antagonist for activated alpha 4 beta 1 integrin. J Med Chem. 2007 Nov 15; 50(23):5863-7. PMID: 17948981.
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    73. Jeddeloh MR, Holden JB, Nouri DH, Kurth M. A library of 3-aryl-4,5-dihydroisoxazole-5-carboxamides. J Comb Chem. 2007 Nov-Dec; 9(6):1041-5. PMID: 17910514.
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    74. Leung PS, Park O, Tsuneyama K, Kurth M, Lam KS, Ansari AA, Coppel RL, Gershwin ME. Induction of primary biliary cirrhosis in guinea pigs following chemical xenobiotic immunization. J Immunol. 2007 Aug 15; 179(4):2651-7. PMID: 17675529.
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    75. Robins LI, Kurth M. 1,3,5-triazine-based mass spectral tagging of one-bead one-compound libraries. Org Lett. 2007 Jan 18; 9(2):171-3. PMID: 17217257.
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    76. Carpenter RD, Lam KS, Kurth M. Microwave-mediated heterocyclization to benzimidazo[2,1-b]quinazolin-12(5H)-ones. J Org Chem. 2007 Jan 05; 72(1):284-7. PMID: 17194113.
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    77. Dixon SM, Milinkevich KA, Fujii J, Liu R, Yao N, Lam KS, Kurth M. A spiroisoxazolinoproline-based amino acid scaffold for solid phase and one-bead-one-compound library synthesis. J Comb Chem. 2007 Jan-Feb; 9(1):143-57. PMID: 17206843.
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    78. Mills AD, Maloney P, Hassanein E, Haddadin MJ, Kurth M. Synthesis of a library of 2-alkyl-3-alkyloxy-2H-indazole-6-carboxamides. J Comb Chem. 2007 Jan-Feb; 9(1):171-7. PMID: 17206845.
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    79. Robins LI, Fettinger JC, Tinti DS, Kurth M. Selective nucleophilic chemistry in the synthesis of 5-carbamoyl-3-sulfanylmethylisoxazole-4-carboxylic acids. J Comb Chem. 2007 Jan-Feb; 9(1):139-42. PMID: 17206842.
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    80. Dixon S, Ziebart KT, He Z, Jeddeloh M, Yoo CL, Wang X, Lehman A, Lam KS, Toney MD, Kurth M. Aminodeoxychorismate synthase inhibitors from one-bead one-compound combinatorial libraries: "staged" inhibitor design. J Med Chem. 2006 Dec 14; 49(25):7413-26. PMID: 17149871.
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    81. Carpenter RD, Deberdt PB, Lam KS, Kurth M. Carbodiimide-based benzimidazole library method. J Comb Chem. 2006 Nov-Dec; 8(6):907-14. PMID: 17096580.
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    82. Robins LI, Dixon SM, Wilson DK, Kurth M. On-bead combinatorial techniques for the identification of selective aldose reductase inhibitors. Bioorg Med Chem. 2006 Dec 01; 14(23):7728-35. PMID: 16931029.
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    83. Dixon SM, Li P, Liu R, Wolosker H, Lam KS, Kurth M, Toney MD. Slow-binding human serine racemase inhibitors from high-throughput screening of combinatorial libraries. J Med Chem. 2006 Apr 20; 49(8):2388-97. PMID: 16610782.
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    84. Mills AD, Nazer MZ, Haddadin MJ, Kurth M. N,N-bond-forming heterocyclization: synthesis of 3-alkoxy-2H-indazoles. J Org Chem. 2006 Mar 31; 71(7):2687-9. PMID: 16555821.
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    85. Robins LI, Carpenter RD, Fettinger JC, Haddadin MJ, Tinti DS, Kurth M. Diazocinones: synthesis and conformational analysis. J Org Chem. 2006 Mar 17; 71(6):2480-5. PMID: 16526800.
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    86. Suen YF, Robins L, Yang B, Verkman AS, Nantz MH, Kurth M. Sulfamoyl-4-oxoquinoline-3-carboxamides: novel potentiators of defective DeltaF508-cystic fibrosis transmembrane conductance regulator chloride channel gating. Bioorg Med Chem Lett. 2006 Feb; 16(3):537-40. PMID: 16288863.
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    88. Yoo CL, Fettinger JC, Kurth M. Stannous chloride in alcohol: a one-pot conversion of 2-nitro-N-arylbenzamides to 2,3-dihydro-1H-quinazoline-4-ones. J Org Chem. 2005 Aug 19; 70(17):6941-3. PMID: 16095321.
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    90. Amano K, Leung PS, Rieger R, Quan C, Wang X, Marik J, Suen YF, Kurth M, Nantz MH, Ansari AA, Lam KS, Zeniya M, Matsuura E, Coppel RL, Gershwin ME. Chemical xenobiotics and mitochondrial autoantigens in primary biliary cirrhosis: identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid. J Immunol. 2005 May 01; 174(9):5874-83. PMID: 15845458.
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    91. Kurth M, Olmstead MM, Haddadin MJ. Claimed 2,1-benzisoxazoles are indazalones. J Org Chem. 2005 Feb 04; 70(3):1060-2. PMID: 15675871.
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    92. Hwang SH, Lehman A, Cong X, Olmstead MM, Lam KS, Lebrilla CB, Kurth M. OBOC small-molecule combinatorial library encoded by halogenated mass-tags. Org Lett. 2004 Oct 14; 6(21):3829-32. PMID: 15469360.
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    93. Amano K, Leung PS, Xu Q, Marik J, Quan C, Kurth M, Nantz MH, Ansari AA, Lam KS, Zeniya M, Coppel RL, Gershwin ME. Xenobiotic-induced loss of tolerance in rabbits to the mitochondrial autoantigen of primary biliary cirrhosis is reversible. J Immunol. 2004 May 15; 172(10):6444-52. PMID: 15128836.
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    94. Quan C, Kurth M. Solid-phase synthesis of 5-isoxazol-4-yl-[1,2,4]oxadiazoles. J Org Chem. 2004 Mar 05; 69(5):1470-4. PMID: 14986998.
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    95. Hwang SH, Olmstead MM, Kurth M. Solid-phase synthesis of an isoxazolinopyrrole library. J Comb Chem. 2004 Jan-Feb; 6(1):142-8. PMID: 14714998.
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    96. Selmi C, Balkwill DL, Invernizzi P, Ansari AA, Coppel RL, Podda M, Leung PS, Kenny TP, Van De Water J, Nantz MH, Kurth M, Gershwin ME. Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium. Hepatology. 2003 Nov; 38(5):1250-7. PMID: 14578864.
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    97. Springsteel MF, Galietta LJ, Ma T, By K, Berger GO, Yang H, Dicus CW, Choung W, Quan C, Shelat AA, Guy RK, Verkman AS, Kurth M, Nantz MH. Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain. Bioorg Med Chem. 2003 Sep 01; 11(18):4113-20. PMID: 12927873.
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    98. Sammelson RE, Ma T, Galietta LJ, Verkman AS, Kurth M. 3-(2-Benzyloxyphenyl)isoxazoles and isoxazolines: synthesis and evaluation as CFTR activators. Bioorg Med Chem Lett. 2003 Aug 04; 13(15):2509-12. PMID: 12852954.
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    99. Leung PS, Quan C, Park O, Van de Water J, Kurth M, Nantz MH, Ansari AA, Coppel RL, Lam KS, Gershwin ME. Immunization with a xenobiotic 6-bromohexanoate bovine serum albumin conjugate induces antimitochondrial antibodies. J Immunol. 2003 May 15; 170(10):5326-32. PMID: 12734383.
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    100. Price MD, Sui JK, Kurth M, Schore NE. Oxazaborolidines as functional monomers: ketone reduction using polymer-supported Corey, Bakshi, and Shibata catalysts. J Org Chem. 2002 Nov 15; 67(23):8086-9. PMID: 12423136.
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    101. Price MD, Kurth M, Schore NE. Comparison of solid-phase and solution-phase chiral auxiliaries in the alkylation/iodolactonization sequence to gamma-butyrolactones. J Org Chem. 2002 Nov 01; 67(22):7769-73. PMID: 12398501.
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    102. Hwang SH, Kurth M. Versatile "traceless" sulfone linker for SPOS: preparation of isoxazolinopyrrole 2-carboxylates. J Org Chem. 2002 Sep 06; 67(18):6564-7. PMID: 12201785.
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    103. Cheng WC, Liu Y, Wong M, Olmstead MM, Lam KS, Kurth M. Stereoselective synthesis of unnatural spiroisoxazolinoproline-based amino acids and derivatives. J Org Chem. 2002 Aug 09; 67(16):5673-7. PMID: 12153267.
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    104. Cheng WC, Kurth M. The sulfone linker in solid-phase synthesis: preparation of 3,5-disubstituted cyclopent-2-enones. J Org Chem. 2002 Jun 28; 67(13):4387-91. PMID: 12076132.
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    105. Liu Y, Kurth M. Ipso substitution as a route to benzo[c]quinolizines and 4-hydroxycoumarins. J Org Chem. 2002 Apr 05; 67(7):2082-6. PMID: 11925212.
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    106. Huang KS, Haddadin MJ, Kurth M. Imidazopyridinium and pyridopyrimidium bromides: synthesis and hydrolysis. J Org Chem. 2002 Apr 05; 67(7):2382-5. PMID: 11925262.
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    107. Cheng WC, Wong M, Olmstead MM, Kurth M. Solid-phase synthesis of novel isoxazolocyclobutanones and isoxazolinocyclobutenones. Org Lett. 2002 Mar 07; 4(5):741-4. PMID: 11869116.
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    108. Sammelson RE, Gurusinghe CD, Kurth JM, Olmstead MM, Kurth M. Synthesis of spiro-fused (C5)-isoxazolino-(C4)-pyrazolones (1-oxa-2,7,8-triazaspiro[4,4]-2,8-dien-6-ones) via 1,3-dipolar cycloaddition and cycloelimination. J Org Chem. 2002 Feb 08; 67(3):876-82. PMID: 11856032.
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    109. Sammelson RE, Olmstead MM, Haddadin MJ, Kurth M. 1,2,4,5-Tetrazines as oxidant and reactant with DBU: An unexpected formation of a novel fused tetraheterocyclic azepine J Org Chem. 2000 Dec 29; 65(26):9265-7. PMID: 11149886.
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    110. Lorsbach BA, Kurth M. Carbonminus signCarbon Bond Forming Solid-Phase Reactions. Chem Rev. 1999 Jun 09; 99(6):1549-1582. PMID: 11849002.
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    111. Halm C, Kurth M. Functionalized Cross-Linked Copolymers: A "C2 -Symmetric" Solid-Phase Catalyst for Enantioselective Reactions. Angew Chem Int Ed Engl. 1998 Mar 02; 37(4):510-512. PMID: 29711160.
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    112. Park KH, Olmstead MM, Kurth M. Diastereoselective Synthesis of Cyclopentanoids with Hydantoin and Isoxazoline Substituents. J Org Chem. 1998 Jan 09; 63(1):113-117. PMID: 11674050.
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    113. Lorsbach BA, Miller RB, Kurth M. Reissert-Based "Traceless" Solid-Phase Synthesis: Isoquinoline, and Isoxazoline-Containing Heterocycles. J Org Chem. 1996 Dec 13; 61(25):8716-8717. PMID: 11667837.
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    114. Kurth M, Ahlberg Randall LA, Takenouchi K. Solid-Phase Combinatorial Synthesis of Polyisoxazolines: A Two-Reaction Iterative Protocol. J Org Chem. 1996 Dec 13; 61(25):8755-8761. PMID: 11667849.
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